559292:YAL034C
gene id: 559292:YAL034C
uniprot id: P28003
names: Miscellaneous
messages: FUN19 is a non-essential gene.

559292:YIL085C
gene id: 559292:YIL085C
uniprot id: P40504
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Membrane
messages: Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
messages: Present with 2890 molecules/cell in log phase SD medium.

559292:YML060W
gene id: 559292:YML060W
uniprot id: P53397
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
messages: Nucleus
messages: Present with 3690 molecules/cell in log phase SD medium.

559292:YOL057W
gene id: 559292:YOL057W
uniprot id: Q08225
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Present with 3260 molecules/cell in log phase SD medium.

559292:YML005W
gene id: 559292:YML005W
uniprot id: Q04235
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Present with 656 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
messages: Was originally thought to be a methyltransferase.
messages: tRNA(Phe) from mutant shows accumulation of 4-demethylwyosine (ImG-14) and absence of wybutosine.

559292:YOR071C
gene id: 559292:YOR071C
uniprot id: Q08485
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Cell membrane
messages: Expression is controlled by the transcription repressors SUM1, HST1 and RFM1.
messages: High-affinity pH-dependent nicotinamide riboside transporter which also transports thiamine with low affinity. Involved in 5-fluorocytosine sensitivity.

559292:YBR162W-A
gene id: 559292:YBR162W-A
uniprot id: P38374
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).
messages: Present with 846 molecules/cell in log phase SD medium.

559292:YLR354C
gene id: 559292:YLR354C
uniprot id: P15019
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Homodimer.
messages: Present with 53000 molecules/cell in log phase SD medium.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
messages: Two isoenzymes seem to be encoded by the same gene.

559292:YJL217W
gene id: 559292:YJL217W
uniprot id: P40893
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: By calcium shortage, copper deficiency (via MAC1) and the presence of galactose (via GAL4).
messages: Cytoplasm
messages: Functions in the galactose metabolic pathway via the GAL83 protein and that it may control the level of ENO1.
messages: Present with 721 molecules/cell in log phase SD medium.

559292:YOR255W
gene id: 559292:YOR255W
uniprot id: Q08692
names: Function
names: Subcellular Location Annotation
messages: May be involved in a late step of spore wall assembly.
messages: Spore wall

559292:YGR059W
gene id: 559292:YGR059W
uniprot id: P41901
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Interacts with other septin proteins such as SPR28 to form a ring at the bud neck.
messages: Prospore membrane
messages: Septins are GTPases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity).
messages: Sporulation-specific.

559292:YBL017C
gene id: 559292:YBL017C
uniprot id: P32319
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family.
messages: Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. May execute multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment. Binds the Golgi-modified P2 form of CPY, and this interaction is dependent on the presence of an intact CPY vacuolar protein sorting signal.
messages: Present with 7210 molecules/cell in log phase SD medium.
messages: Prevacuolar compartment membrane
messages: The lumenal domain contains two regions of approximately 650 AA that exhibit 20% identity. The cytoplasmic domain serves as a Golgi retention/recycling signal.
messages: trans-Golgi network membrane

559292:YIR036C
gene id: 559292:YIR036C
uniprot id: P40580
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: By single-strand DNA damage.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.
messages: Present with 1620 molecules/cell in log phase SD medium.
messages: Reduces benzil stereospecifically to (S)-benzoin. Is probably involved in a pathway contributing to genomic integrity.

559292:YER086W
gene id: 559292:YER086W
uniprot id: P00927
names: Activity Regulation
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Homotetramer.
messages: In response to starvation for tryptophan and branched-chain amino acid imbalance.
messages: Isoleucine allosterically inhibits while valine allosterically activates this enzyme.
messages: Mitochondrion
messages: Present with 11900 molecules/cell in log phase SD medium.

559292:YNR034W-A
gene id: 559292:YNR034W-A
uniprot id: Q3E841
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 2820 molecules/cell in log phase SD medium.

559292:YBR242W
gene id: 559292:YBR242W
uniprot id: P38331
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Binds 2 divalent metal cations (By similarity). Shows activity with Mn(2+), Co(2+) and Mg(2+) but shows no activity with Zn(2+) (PubMed:29752939).
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.
messages: Present with 2730 molecules/cell in log phase SD medium.

559292:YML082W
gene id: 559292:YML082W
uniprot id: Q04533
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family. MET7 subfamily.
messages: Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).
messages: Present with 2810 molecules/cell in log phase SD medium.

559292:YJR010C-A
gene id: 559292:YJR010C-A
uniprot id: P46965
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS1 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (PubMed:9148931). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (PubMed:10921929). Interacts with SBH1 and SEB2/SBH2 (PubMed:10921929).
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:8663399). Dispensable for SPC enzymatic activity (PubMed:8663399).
messages: Endoplasmic reticulum membrane
messages: Present with 5550 molecules/cell in log phase SD medium.

559292:YOR021C
gene id: 559292:YOR021C
uniprot id: Q12314
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase SFM1 family.
messages: Cytoplasm
messages: Present with 2520 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146'.

559292:YPR032W
gene id: 559292:YPR032W
uniprot id: Q12038
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Coordinates the spatial and temporal nature of both Rab-dependent tethering and SNARE-dependent membrane fusion of exocytic vesicles with the plasma membrane. Required for targeting of the sodium pumping ATPase ENA1 to the Cell Surface, thus being involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth.
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with MYO2 and SEC9.

559292:YML131W
gene id: 559292:YML131W
uniprot id: Q03102
names: Subcellular Location Annotation
messages: Membrane

559292:YBR207W
gene id: 559292:YBR207W
uniprot id: P38310
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: High affinity iron transporter probably involved in transport of intravacuolar stores of iron.
messages: Interacts with FET5.
messages: Present with 486 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YML096W
gene id: 559292:YML096W
uniprot id: Q04489
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 3750 molecules/cell in log phase SD medium.

559292:YAL031C
gene id: 559292:YAL031C
uniprot id: P39732
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GIP4 family.
messages: Cytoplasm
messages: GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.
messages: Interacts with GLC7.
messages: Present with 227 molecules/cell in log phase SD medium.

559292:YCL001W-A
gene id: 559292:YCL001W-A
uniprot id: P87012
names: Similarity
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily. Highly divergent.

559292:YER033C
gene id: 559292:YER033C
uniprot id: P40021
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZRG8 family.
messages: Bud
messages: Bud neck
messages: Bud tip
messages: Cytoplasm
messages: Interacts with BUD27, GIS1 and SSD1.
messages: Involved in the integrity functions of RAM, a conserved signaling network that regulates maintenance of polarized growth and daughter-cell-specific transcription.
messages: Repressed by zinc.

559292:YPR114W
gene id: 559292:YPR114W
uniprot id: Q06107
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 1920 molecules/cell in log phase SD medium.

559292:YDL179W
gene id: 559292:YDL179W
uniprot id: Q12477
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the cyclin family. PCL1,2 subfamily.
messages: By transcription factor SWI5 in a cell cycle-regulated manner. Peaks in late M, early G1 phase (at protein level).
messages: Forms a cyclin-CDK complex with PHO85.
messages: M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. May have a role in bud site selection in G1 phase.

559292:YJL206C
gene id: 559292:YJL206C
uniprot id: P39529
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASG1 family.
messages: Nucleus
messages: Weakly cell cycle regulated, peaking in S phase.

559292:YDR402C
gene id: 559292:YDR402C
uniprot id: P21595
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Involved in spore wall maturation. Thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine a precursor of the spore wall.
messages: Sporulation.

559292:YAL068C
gene id: 559292:YAL068C
uniprot id: P0CE92
uniprot id: P0CE93
uniprot id: Q3E770
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YHR102W
gene id: 559292:YHR102W
uniprot id: P38692
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with CDC31.
messages: Present with 1040 molecules/cell in log phase SD medium.
messages: Protein kinase involved in morphogenesis and cell integrity.

559292:YBR085C-A
gene id: 559292:YBR085C-A
uniprot id: O43137
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

559292:YGL137W
gene id: 559292:YGL137W
uniprot id: P41811
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with the ESCRT-0 subunit VPS27.
messages: Present with 129000 molecules/cell in log phase SD medium.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

559292:YBL023C
gene id: 559292:YBL023C
uniprot id: P29469
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; specifically the MCM2-MCM5 association is proposed to be reversible and to mediate a open ring conformation which may facilitate DNA loading. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Necessary for cell growth.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer.
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus
messages: Present with 1690 molecules/cell in log phase SD medium.

559292:YHL006C
gene id: 559292:YHL006C
uniprot id: P38751
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2.
messages: Nucleus
messages: Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase.

559292:YKR046C
gene id: 559292:YKR046C
uniprot id: P36139
names: Miscellaneous
names: Subcellular Location Annotation
messages: Lipid droplet
messages: Membrane
messages: Present with 2157 molecules/cell in log phase SD medium.

559292:YJL084C
gene id: 559292:YJL084C
uniprot id: P47029
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALY1 family.
messages: Cytoplasm
messages: Interacts with PCL6, PCL7 and RSP5.
messages: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
messages: Phosphorylated by the cyclin-CDKs PCL6-PHO85 and PCL7-PHO85.
messages: Present with 49 molecules/cell in log phase SD medium.
messages: Ubiquitinated by RSP5.

559292:YMR050C
gene id: 559292:YMR050C
uniprot id: Q04670
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YMR051C ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YBR256C
gene id: 559292:YBR256C
uniprot id: P38145
names: Function
names: Miscellaneous
names: Subunit
messages: Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
messages: Homotrimer.
messages: Present with 7300 molecules/cell in log phase SD medium.

559292:YMR158W
gene id: 559292:YMR158W
uniprot id: Q03799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion

559292:YMR311C
gene id: 559292:YMR311C
uniprot id: P41818
names: Function
names: Miscellaneous
names: PTM
messages: Modulator of GLC7 type-1 protein phosphatase.
messages: Phosphorylated by the cyclin-CDKs PCL6-PHO85 and PCL7-PHO85. Phosphorylation of Thr-118 inactivates GLC8.
messages: Present with 3440 molecules/cell in log phase SD medium.

559292:YDR488C
gene id: 559292:YDR488C
uniprot id: P40960
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with NUM1, when DYN1 is present.
messages: Present with 752 molecules/cell in log phase SD medium.
messages: Required for viability in the absence of the kinesin-related CIN8 mitotic motor. May be a dynein intermediate chain.
messages: cytoskeleton

559292:YOL121C
gene id: 559292:YOL121C
uniprot id: P07280
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS19 is required for proper maturation of the small (40S) ribosomal subunit. Binds to 40S pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA (PubMed:16159874, PubMed:17726054).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Disruption of a single RPS19 gene reduces cell growth; a double disruption is lethal. Depletion experiments show the proteins are required for correct maturation of precursor rRNA to generate the 18S small rRNA. A specific site between the 18S and 5.8S precursors (site A2 in ETS1) is not cleaved in disruption mutants. Partially assembled ribosomes are retained in the nucleolus rather than being exported to the cytoplasm. All effects are exacerbated in the double disruption. Increases association of NOC4 with 20S/21S pre-rRNA, decreases association of ENP1, TSR1 and RIO2 with 20S/21S pre-rRNA.
messages: Present with 29000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS19 in yeast.

559292:YGR169C-A
gene id: 559292:YGR169C-A
uniprot id: Q3E772
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with translationally inactive ribosomes in the nonrotated state. LSO2 bridges the decoding sites of the small with the GTPase activating center (GAC) of the large subunit. This position allows accommodation of the DOM34-dependent ribosome recycling system, which splits LSO2-containing ribosomes.
messages: Belongs to the CCDC124 family.
messages: Constitutively expressed. Expression is not regulated by iron unlike the LSO1 paralog.
messages: Cytoplasm
messages: Mild slow-growth phenotype in response to reduced iron levels (PubMed:26450372). Displays global translation defects during recovery from stationary phase with translation of most genes reduced more than 4-fold. Ribosomes accumulated at start codons, were depleted from stop codons, and showed codon-specific changes in occupancy (PubMed:30208026).
messages: Nucleus
messages: Ribosome-associated protein required for translational recovery after starvation from stationary phase. May facilitate rapid translation reactivation by stabilizing the recycling-competent state of inactive ribosomes.

559292:YFR034C
gene id: 559292:YFR034C
uniprot id: P07270
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a homodimer. Interacts with transcription factor PHO2 and binds cooperatively to PHO5 UAS. Interacts with the cyclin-CDK PHO80-PHO85 and the CDK inhibitor (CKI) PHO81.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by the cyclin-CDK PHO80-PHO85 at five residues under high-phosphate conditions, preventing PHO4 from activating the structural PHO genes. Phosphorylation of Ser-114 and Ser-128 promotes nuclear export. Phosphorylation of Ser-152 decreases nuclear import. Phosphorylation of Ser-223 decreases the binding affinity for PHO2.
messages: The 9aaTAD motif (residues 75 to 83) is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions. Binds to the upstream activating sequence (UAS) of several phosphatase encoding PHO genes. Inhibited by the cyclin-CDK PHO80-PHO85 under high-phosphate conditions.

559292:YNL112W
gene id: 559292:YNL112W
uniprot id: P24783
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing (PubMed:11585918, PubMed:7883168). Associates directly with chromatin, correlating with transcriptional activity (PubMed:22679025). Required for assembly of mRNA-binding proteins YRA1, NAB2, and MEX67 onto poly(A)+ RNA (PubMed:23721653).
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Cytoplasm
messages: Interacts with UPF1. Associates with polysomes.
messages: Nucleus
messages: Present with 33100 molecules/cell in log phase SD medium.
messages: Results in defective assembly of nuclear mRNPs.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: The gene for DBP2 has an unusual intron both because of its size and because of its location near the 3' end of the gene. It may have a function in an intron-mediated negative feedback loop regulating DBP2 expression.

559292:YGL236C
gene id: 559292:YGL236C
uniprot id: P53070
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Forms a heterodimer with MSS1.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
messages: Mitochondrion

559292:YFR016C
gene id: 559292:YFR016C
uniprot id: P43597
names: Miscellaneous
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YNL158W
gene id: 559292:YNL158W
uniprot id: P53896
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Essential component of the GPI mannosyltransferase 2 complex. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.
messages: Part of the GPI mannosyltransferase 2 complex composed of GPI18 and PGA1.
messages: Present with 6940 molecules/cell in log phase SD medium.

559292:YER176W
gene id: 559292:YER176W
uniprot id: P32644
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm
messages: ECM32 was originally identified as a DNA helicase and as component of DNA polymerase I.
messages: Interacts with the peptidyl release factors SUP35 and weakly with SUP45.
messages: Present with 736 molecules/cell in log phase SD medium.
messages: Probable RNA helicase, which may be involved in modulation of the translation termination process. Probably unwinds double-stranded RNA. In vitro, unwinds covalently closed, circular DNA in the presence of a DNA topoisomerase TOP1 and replication factor-A protein RFA1.
messages: Sensitivity to drugs that affect translation fidelity. Overexpression results in a nonsense suppression phenotype.

559292:YHR198C
gene id: 559292:YHR198C
uniprot id: P38884
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM18/AIM46 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion
messages: Present with 1350 molecules/cell in log phase SD medium.

559292:YLR290C
gene id: 559292:YLR290C
uniprot id: Q05892
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome (PubMed:25683707). Component of a multi-subunit COQ enzyme complex (PubMed:25631044).
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression (PubMed:25683707). Component of a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis (PubMed:25631044).
messages: Mitochondrion
messages: Present with 1470 molecules/cell in log phase SD medium.
messages: Shows impaired de novo coenzyme Q biosynthesis.

559292:YOR192C
gene id: 559292:YOR192C
uniprot id: Q08579
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Induced by limited extracellular thiamine levels.
messages: Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins.
messages: Membrane

559292:YDR524C-B
gene id: 559292:YDR524C-B
uniprot id: Q3E6R4
names: Subcellular Location Annotation
messages: Cell membrane

559292:YGR013W
gene id: 559292:YGR013W
uniprot id: P53207
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNU71 family.
messages: Component of the 18S U1 snRNP particle, a subcomplex of the spliceosome.
messages: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
messages: Cytoplasm
messages: Nucleus
messages: Present with 782 molecules/cell in log phase SD medium.

559292:YDR115W
gene id: 559292:YDR115W
uniprot id: Q04598
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL34 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 200 molecules/cell in log phase SD medium.

559292:YOL078W
gene id: 559292:YOL078W
uniprot id: Q08236
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated by TORC2.
messages: Belongs to the SIN1 family.
messages: Cell membrane
messages: Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
messages: Present with 704 molecules/cell in log phase SD medium.
messages: The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin. AVO1 is required for TORC2 integrity by tethering AVO2 and TSC11 to the complex.
messages: Vacuole membrane

559292:YLR406C
gene id: 559292:YLR406C
uniprot id: P0C2H9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 57500 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL31 in yeast.

559292:YIL057C
gene id: 559292:YIL057C
uniprot id: P40188
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RGI1 family.
messages: Cytoplasm
messages: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
messages: Present with 5530 molecules/cell in log phase SD medium.
messages: Up-regulated under carbon limitation and repressed under high glucose.

559292:YBR245C
gene id: 559292:YBR245C
uniprot id: P38144
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Catalytic component of ISW1-type complexes, which act by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. They are involved in coordinating transcriptional repression, activation and elongation phases. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.
messages: Component of the ISW1A complex, which at least consists of ISW1 and IOC3. Component of the ISW1B complex, which at least consists of ISW1, IOC2 and IOC4.
messages: Nucleus
messages: Present with 1500 molecules/cell in log phase SD medium.

559292:YOR056C
gene id: 559292:YOR056C
uniprot id: Q08444
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOB1 family.
messages: Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex). Interacts with PNO1.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Present with 4490 molecules/cell in log phase SD medium.
messages: Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. In association with NIN1, may promote the recruitment of the proteasome to the ribosomal subunits stalled in maturation.
messages: nucleolus

559292:YOR019W
gene id: 559292:YOR019W
uniprot id: Q99248
names: Developmental Stage
messages: Periodic expression during the cell cycle with a peak at S phase.

559292:YOR111W
gene id: 559292:YOR111W
uniprot id: Q99210
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze the modified nucleotides 5-methyl-UTP (m(5)UTP) and pseudo-UTP. Has weak activity with CTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219).
messages: Present with 1940 molecules/cell in log phase SD medium.

559292:YGL143C
gene id: 559292:YGL143C
uniprot id: P30775
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals (By similarity). N5-methylated on Gln-287 by MTQ1.
messages: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.
messages: Mitochondrion
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YKR034W
gene id: 559292:YKR034W
uniprot id: P26343
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Negative regulator of multiple nitrogen catabolic genes including the allantoin pathway genes.
messages: Nucleus
messages: Sensitive to nitrogen catabolite repression.

559292:YPL119C
gene id: 559292:YPL119C
uniprot id: P24784
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Redundant to DED1, may be required in conditions in which DED1 expression is decreased.
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: Present with 1480 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

559292:YNL137C
gene id: 559292:YNL137C
uniprot id: P27929
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uS3m, uS4m and uS5m form the narrow entry site of the mRNA channel.
messages: Mitochondrion
messages: Present with 3270 molecules/cell in log phase SD medium.

559292:YNL232W
gene id: 559292:YNL232W
uniprot id: P53859
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:17173052 and PubMed:17174896, only DIS3/RRP44 subunit of the exosome core has exonuclease activity.
messages: Belongs to the CSL4 family.
messages: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure.
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
messages: Present with 5550 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR211C
gene id: 559292:YLR211C
uniprot id: Q05789
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Autophagy-related protein required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG38 is required for the integrity of the active PI3-kinase complex I by maintaining an association between VPS15-VPS34 and ATG1P-VPS30 subcomplexes.
messages: Cytoplasm
messages: Homodimer. Component of the autophagy-specific VPS34 PI3-kinase complex I composed of VPS15, VPS30, VPS34, ATG14 and ATG38. Interacts directly with ATG14 and VPS34.
messages: Preautophagosomal structure membrane

559292:YDR231C
gene id: 559292:YDR231C
uniprot id: Q04935
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX20 family.
messages: Interacts with COX2.
messages: Involved in the assembly of the cytochrome oxidase complex. Required for the maturation and subsequent assembly of the mitochondrially encoded COX2, the precursor of subunit 2 of cytochrome oxidase.
messages: Mitochondrion inner membrane

559292:YOR354C
gene id: 559292:YOR354C
uniprot id: Q08818
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: May be involved in the control of meiotic sister-chromatid recombination.
messages: Mitochondrion
messages: Present with 7250 molecules/cell in log phase SD medium.

559292:YDL095W
gene id: 559292:YDL095W
uniprot id: P33775
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects glycosylation of chitinase and increases sensitivity to calcofluor white and caffeine.
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: PMT1 and PMT2 form a functional heterodimer. The complex interacts with endoplasmic reticulum proteins EMP24, ERV25, ERP1, ERP2, CDC48, HRD1, USA1, YOS9, ERO1, PDI1, UBR1, Cue4, DFM1 and TED1. Forms also a minor complex with PMT3.
messages: Present with 41500 molecules/cell in log phase SD medium.
messages: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT3 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export. Required for incorporation of proteins in the cell wall.
messages: The large luminal loop 5 is essential for mannosyltransferase activity but not for PMT1-PMT2 complex formation.

559292:YJL049W
gene id: 559292:YJL049W
uniprot id: P47048
names: Miscellaneous
messages: Present with 2530 molecules/cell in log phase SD medium.

559292:YLR291C
gene id: 559292:YLR291C
uniprot id: P32502
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as a regulatory component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD6 and GCD7 repress GCN4 expression at the translational level by ensuring that ribosomes which have translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail to reach the GCN4 start site.
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Present with 6650 molecules/cell in log phase SD medium.
messages: Translation initiation factor 2B (eIF2-B) is composed of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6). A regulatory subcomplex comprising GCN3, GCD7 and GCD2 interacts preferentially with phosphorylated eIF-2 and has no exchange activity in vitro.

559292:YCL055W
gene id: 559292:YCL055W
uniprot id: P25583
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MT-A70-like family.
messages: May assist STE12 in the pheromone-dependent expression of KAR3 and CIK1. Also required for meiosis.
messages: Nucleus
messages: Present with 1690 molecules/cell in log phase SD medium.

559292:YHR107C
gene id: 559292:YHR107C
uniprot id: P32468
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SHS1 and rearranges to a cortical collar of highly ordered filaments at the mother-bud-neck. A complex formed by CDC3, CDC10, CDC11 and CDC12 is capable of forming long filaments in vitro and the components seem to be present in a 2:2:2:2 arrangement in vivo. The filaments are proposed to be formed by the end-to-end polymerization of CDC3-CDC12-CDC11 complexes with CDC10 serving as a bridge to bundle the polymers into paired filaments. Component of the GIN4 complex composed of at least BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. Self-associates. Interacts with SYP1.
messages: Membrane
messages: Present with 1170 molecules/cell in log phase SD medium.
messages: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.

559292:YOR022C
gene id: 559292:YOR022C
uniprot id: Q12204
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-PLA1 family.
messages: Mitochondrion
messages: Present with 736 molecules/cell in log phase SD medium.
messages: Probable phospholipase that hydrolyzes phosphatidic acid.

559292:YGR257C
gene id: 559292:YGR257C
uniprot id: P53320
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Involved in the mitochondrial activation of SOD2 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner. Responds to calorie restriction (CR) strength.
messages: Loss of mitochondrial manganese superoxide dismutase SOD2 activity due to misincorporation of iron into SOD2 rather than manganese. Normal SOD2 activity when in association with YFH1 deletion. Doesn't impair activity of a cytosolic version of manganese SOD. The iron regulatory transcription factor AFT1 is constitutively active. Accumulates mtDNA mutations. Elevated mitochondrial iron and manganese levels.
messages: Mitochondrion inner membrane
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YNR031C
gene id: 559292:YNR031C
uniprot id: P53599
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Interacts with by SSK1.
messages: Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.
messages: Present with 217 molecules/cell in log phase SD medium.

559292:YLR189C
gene id: 559292:YLR189C
uniprot id: Q06321
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Cytoplasm
messages: Membrane
messages: Present with 396 molecules/cell in log phase SD medium.
messages: Probable sterol 3-beta-glucosyltransferase that is not involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy (PubMed:17012830).

559292:YPL085W
gene id: 559292:YPL085W
uniprot id: P48415
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SEC23, SEC31 and SED4.
messages: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YGR101W
gene id: 559292:YGR101W
uniprot id: P53259
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Mitochondrial rhomboid serine protease processing the mitochondrial membrane fusion regulator MGM1, and the cytochrome c peroxidase (CCP1). Required for TIM11 stability, ATP synthase complex assembly, mitochondrial morphology, cytochrome c (CYC1) storage and mitochondrial genome maintenance.
messages: Mitochondrion inner membrane

559292:YJL121C
gene id: 559292:YJL121C
uniprot id: P46969
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+).
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate (By similarity). Involved in the protective response to oxidative stress.
messages: Cytoplasm
messages: Present with 3310 molecules/cell in log phase SD medium.

559292:YOR284W
gene id: 559292:YOR284W
uniprot id: Q12134
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May have a role in actin patch assembly.
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YDL145C
gene id: 559292:YDL145C
uniprot id: P53622
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with the ESCRT-0 subunit VPS27. Interacts with KEI1 (via C-terminal region).
messages: Present with 15200 molecules/cell in log phase SD medium.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

559292:YNR075C-A
gene id: 559292:YNR075C-A
uniprot id: Q8TGJ2
names: Similarity
messages: Belongs to the UPF0377 family.

559292:YOR204W
gene id: 559292:YOR204W
uniprot id: P06634
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes. Has weak ATP-dependent affinity for dsRNA, but strong ATP-dependent affinity for ssRNA. Acts as a virus host factor involved in the replication of the MBV and the L-A viruses by promoting the negative-strand RNA synthesis. May be involved in recognition of the preinitiation complex and DNA binding of the RNA polymerase III and play a role in mRNA splicing.
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: Interacts with the L-A virus GAG protein and the whole L-A virus particles.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

559292:YCR073W-A
gene id: 559292:YCR073W-A
uniprot id: P37262
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Cytoplasm
messages: Lacks 6-phosphogluconolactonase activity.
messages: May be involved in regulation of tRNA subcellular distribution.
messages: Present with 1160 molecules/cell in log phase SD medium.

559292:YPL283C
gene id: 559292:YPL283C
uniprot id: P0CX14
uniprot id: P0CX15
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YGR217W
gene id: 559292:YGR217W
uniprot id: P50077
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Cell membrane
messages: Interacts with MID1 to form a Ca(2+) influx channel.
messages: Membrane
messages: Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with MID1 to ensure that adequate levels of Ca(2+) are supplied to PMR1 to sustain secretion and growth. Required for growth in low-calcium environments.

559292:YGR130C
gene id: 559292:YGR130C
uniprot id: P53278
names: Miscellaneous
names: PTM
messages: Present with 10300 molecules/cell in log phase SD medium.
messages: Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7) (PubMed:15604408). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:15604408, PubMed:17873058).

559292:YPL234C
gene id: 559292:YPL234C
uniprot id: P32842
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Present with 538 molecules/cell in log phase SD medium.
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1837023, PubMed:9030535). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1837023, PubMed:9030535).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:27776355, PubMed:29526695). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c'' (PubMed:27776355, PubMed:29526695).
messages: Vacuole membrane

559292:YNL049C
gene id: 559292:YNL049C
uniprot id: P53953
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII is composed of at least five proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Interacts with GRH1.
messages: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Present with 1720 molecules/cell in log phase SD medium.

559292:YGR033C
gene id: 559292:YGR033C
uniprot id: P53220
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts directly with TIM23. Interacts with TOM22 component of the TOM complex. Released from the TOM23 complex by the PAM complex, leading to protein translocation into the mitochondrial matrix.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix. In the complex, it acts as an antagonist of TIM50 by reducing preprotein accumulation at the TOM23 complex and promotes dissociation of the PAM complex from the TIM23 complex.
messages: Mitochondrion inner membrane
messages: Present with 3770 molecules/cell in log phase SD medium.

559292:YDR058C
gene id: 559292:YDR058C
uniprot id: P54857
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MIA40; forms mixed disulfide intermediates with MIA40.
messages: Mitochondrial triacylglycerol (TAG) lipase with activity toward long-chain diacylglycerols (DAGs) and triacylglycerols (TAGs) (PubMed:9544243, PubMed:19959834). Involved in mitochondrial lipid metabolism (PubMed:31483742).
messages: Mitochondrion
messages: Mitochondrion intermembrane space

559292:YOR207C
gene id: 559292:YOR207C
uniprot id: P22276
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
messages: Nucleus
messages: Present with 1950 molecules/cell in log phase SD medium.

559292:YKR089C
gene id: 559292:YKR089C
uniprot id: P36165
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: A double deletion of TGL3 and TGL4, the 2 major TGA lipases, leads to fat yeast, rendering growing cells unable to degrade triglycerides.
messages: Lipid droplet
messages: Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate metabolic pathways (PubMed:16135509, PubMed:16267052). Also has steryl ester (SE) hydrolase and phospholipase A(2) (PLA(2)) activities, and catalyzes the acylation of lysophosphatidic acid (LPA) (PubMed:20332534). Contributes to early bud formation in late G1 phase of the cell cycle upon phosphorylation and activation by cyclin-dependent kinase 1 (Cdk1/CDC28) (PubMed:19150427).
messages: Phosphorylated and activated by cyclin-dependent kinase 1 (Cdk1/CDC28) (PubMed:19150427). Loses its lipolytic activity in cells lacking nonpolar lipids, but retains its side activity as lysophospholipid acyltransferase (PubMed:27170177).
messages: Phosphorylation at Thr-675 and Ser-890 by Cdk1/CDC28 stimulates enzyme activity in vivo.
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YNR004W
gene id: 559292:YNR004W
uniprot id: P40342
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWM2 family.
messages: Leads to cold-sensitive growth and elongated buds. Is synthetic lethal with a MUD2 deletant.
messages: Present with 1720 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDL098C
gene id: 559292:YDL098C
uniprot id: Q12368
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Nucleus
messages: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
messages: Present with 907 molecules/cell in log phase SD medium.

559292:YFL002C
gene id: 559292:YFL002C
uniprot id: P25808
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (PubMed:2408148, PubMed:25579579). Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA (PubMed:21825077). Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2 (PubMed:9769101). Also required for recruitment of NOG2 to pre-ribosomes (PubMed:22735702).
messages: Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
messages: Component of pre-60S ribosomal complexes.
messages: Present with 5740 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YBR072W
gene id: 559292:YBR072W
uniprot id: P15992
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: By heat shock, and under other conditions of stress, such as increased salt concentration and starvation.
messages: Expressed during the entry into stationary phase resulting from glucose limitation.
messages: Not known. One of the major polypeptides produced on heat shock.
messages: Present in large complexes.
messages: Present with 19300 molecules/cell in log phase SD medium.

559292:YLR445W
gene id: 559292:YLR445W
uniprot id: Q06201
names: Function
names: Induction
messages: Expression is induced in response to alpha factor and regulated by the UME6 transcription factor.
messages: Probable transcriptional activator involved in meiotic prophase and synaptonemal complex (SC) assembly.

559292:YIL061C
gene id: 559292:YIL061C
uniprot id: Q00916
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the spliceosome, where it is associated with snRNP U1. Binds stem loop I of U1 snRNA. Interacts with mRNA.
messages: Involved in nuclear mRNA splicing.
messages: Nucleus
messages: Present with 736 molecules/cell in log phase SD medium.

559292:YDR167W
gene id: 559292:YDR167W
uniprot id: Q12030
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF10 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
messages: In TFIID, TAF10 heterodimerizes with TAF3 and TAF8. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. Component of the 1.8 MDa SAGA complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9.
messages: Nucleus
messages: Present with 3400 molecules/cell in log phase SD medium.

559292:YAL046C
gene id: 559292:YAL046C
uniprot id: P39724
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH) (PubMed:27532773, PubMed:27532772). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532772). Acts together with NFU1, later than BOL1 and GRX5 in the [4Fe-4S] cluster insertion process (PubMed:27532773). Not required for [2Fe-2S] cluster insertion into mitochondrial proteins (PubMed:27532772).
messages: Belongs to the BolA/IbaG family.
messages: Increases frequency of mitochondrial genome loss (PubMed:19300474). Cells show a slight decrease of succinate dehydrogenase (SDH) (PubMed:27532772). Cells lacking BOL1 and BOL3 display defects in a subset of mitochondrial [4Fe-4S] enzymes (PubMed:27532773, PubMed:27532772).
messages: Interacts with NFU1 (PubMed:27532773).
messages: Mitochondrion matrix
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YOR189W
gene id: 559292:YOR189W
uniprot id: Q08561
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YMR166C
gene id: 559292:YMR166C
uniprot id: Q03829
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Present with 2060 molecules/cell in log phase SD medium.
messages: Significantly increases steady-state mitochondrial magnesium concentration (PubMed:25585246). Rescues the group II RNA splicing defect in the MRS2 and LPE10 deletion mutants (PubMed:25585246).
messages: Transporter of the mitochondrial inner membrane that exports magnesium and thus, plays a key role in mitochondrial Mg(2+) homeostasis.

559292:YML049C
gene id: 559292:YML049C
uniprot id: Q04693
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RSE1 family.
messages: Belongs to the SF3B complex, a U2 associated sub-complex of the spliceosome. The SF3B complex is composed of at least CUS1, HSH49, HSH155, RDS3 and RSE1. Belongs also to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with RDS3.
messages: Involved in G2/M transition (By similarity). Required for pre-mRNA splicing and endoplasmic reticulum (ER) to Golgi secretion pathway. U2 snRNPs associated protein required for the pre-spliceosome assembly. The involvement in ER to Golgi secretion is probably indirect and due to the splicing of the pre-mRNA coding for SAR1, a small GTP-binding protein required for COPII vesicle formation from the ER.
messages: Nucleus

559292:YDL039C
gene id: 559292:YDL039C
uniprot id: Q12459
names: Induction
messages: Induced by pheromone. Down-regulated by RIM101 and inositol.

559292:YEL046C
gene id: 559292:YEL046C
uniprot id: P37303
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.
messages: Homotetramer.
messages: Present with 106000 molecules/cell in log phase SD medium.

559292:YLR238W
gene id: 559292:YLR238W
uniprot id: Q06001
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
messages: Membrane
messages: Participates in the control of the reentry into the cell cycle following pheromone treatment.

559292:YGR288W
gene id: 559292:YGR288W
uniprot id: P53338
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL13 family.
messages: Nucleus
messages: Regulates the coordinate transcription of structural MAL1S (maltase) and AGT1 (maltose permease) genes.

559292:YCL059C
gene id: 559292:YCL059C
uniprot id: P25586
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Cold-sensitive mutant KRR1-21 is a deletion of amino acids 234-239.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.
messages: Present with 4340 molecules/cell in log phase SD medium.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.
messages: nucleolus

559292:YDR059C
gene id: 559292:YDR059C
uniprot id: P15732
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: By heat shock and cadmium.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:19920177, PubMed:2154373). Mediates the selective degradation of short-lived and abnormal proteins (PubMed:2154373). The RSP5-UBA1-UBC5 ubiquitin ligase complex ubiquitinates RPO21 forming 'Lys-63'-linked polyubiquitin chains (PubMed:19920177).
messages: Component of the RSP5-UBA1-UBC5 ubiquitin ligase complex composed of E3 RSP5, E1 UBA1 and E2 UBC5.
messages: Present with 981 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YGL001C
gene id: 559292:YGL001C
uniprot id: P53199
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.
messages: Inhibited by FR171456, a natural product with broad antifungal activity.
messages: Present with 2580 molecules/cell in log phase SD medium.
messages: Sterol-4-alpha-carboxylate 3-dehydrogenase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:9811880, PubMed:15995173). ERG26 is a catalytic component of the C-4 demethylation complex that catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group (PubMed:9811880). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduct…

559292:YNL031C
gene id: 559292:YNL031C
uniprot id: P61830
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5, a component of the SAGA complex, is promoted by H3S10ph. Further acetylated by GCN5 to form H3K9ac, H3K18ac, H3K23ac, H3K27ac and H3K36ac. H3K14ac can also be formed by ESA1, a component of the NuA4 histone acetyltransferase (HAT) complex. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP, UAF seems to stimulate basal transcription to a fully activated level.
messages: Crotonylation (Kcr) marks active promoters and enhancers and confers resistance to transcriptional repressors.
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1.
messages: Nucleus
messages: Phosphorylated by IPL1 to form H3S10ph in a cell cycle-dependent manner during mitosis and meiosis. H3S10ph is also formed by SNF1, promotes subsequent H3K14ac formation by GCN5, and is required for transcriptional activation through TBP recruitment to the promoters. Dephosphorylation is performed by GLC7.
messages: Present with 213000 molecules/cell in log phase SD medium.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Histone H3 is a component of the UAF (upstream activation factor) complex, which consists of UAF30, RRN5, RRN9, RRN10, and histones H3 and H4.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

559292:YDR163W
gene id: 559292:YDR163W
uniprot id: Q03772
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Belongs to the CWC15 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

559292:YJL054W
gene id: 559292:YJL054W
uniprot id: P47045
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM54 family.
messages: Component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54, associated with the peripheral proteins MRS5/TIM12 and the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).
messages: Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. Its precise function within the TIM22 complex is unclear.
messages: Mitochondrion inner membrane

559292:YIL172C
gene id: 559292:YIL172C
uniprot id: P0CW40
uniprot id: P0CW41
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides. Not required for isomaltose utilization, but overexpression allows the IMA1 null mutant to grow on isomaltose.
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm
messages: Present with 166 molecules/cell in log phase SD medium.

559292:YDR159W
gene id: 559292:YDR159W
uniprot id: P46674
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAC3 family.
messages: Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket.
messages: Heterodimer with THP1. The SAC3-THP1 complex interacts with CDC31 and SUS1, and with the mRNA export factor MEX67-MTR2, the TREX complex component SUB2, and the nucleoporin NUP1. SAC3 directly interacts with MEX67, NUP1 and SUB2.
messages: Nucleus envelope
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YLR244C
gene id: 559292:YLR244C
uniprot id: Q01662
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 60S ribosomal subunit of the 80S translational complex.
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays the major role in N-terminal methionine removal. Less efficient when the second residue is Val.
messages: Cytoplasm
messages: In contract to the MetAP 2 isoform, is not inhibited by the fungal metabolite fumagillin, an antiangiogenic drug.
messages: Present with 19600 molecules/cell in log phase SD medium.
messages: The C6H2-type zinc finger recruits ZNG1, promoting zinc cofactor transfer in the peptidase domain of MAP1.

559292:YGR009C
gene id: 559292:YGR009C
uniprot id: P40357
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Component of a SNARE complex that may be the effector of SEC4 function in exocytosis.
messages: Interacts with SRO7 and SRO77.

559292:YCR026C
gene id: 559292:YCR026C
uniprot id: P25353
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated as part of the catalytic cycle of phosphodiesterase/pyrophosphatase activity.
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP2 and PHO5.
messages: Membrane
messages: N-glycosylated.
messages: Present with 3420 molecules/cell in log phase SD medium.
messages: Up-regulated during phosphate starvation.

559292:YMR276W
gene id: 559292:YMR276W
uniprot id: P48510
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Involved, with RAD23 in spindle pole body duplication. Involved in the ubiquitin-proteasome proteolytic pathway.
messages: Nucleus
messages: Present with 3930 molecules/cell in log phase SD medium.

559292:YJL073W
gene id: 559292:YJL073W
uniprot id: P40358
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a DnaJ-like chaperone required for nuclear membrane fusion during mating.
messages: Endoplasmic reticulum membrane
messages: Interacts with MPS3.
messages: Nucleus membrane
messages: Present with 3180 molecules/cell in log phase SD medium.

559292:YHR124W
gene id: 559292:YHR124W
uniprot id: P38830
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds to DNA as a monomer.
messages: Induced during prophase I of meiosis. Requires protein kinase IME2 for initial expression and continued transcription during meiotic divisions. Can autoactivate its own synthesis.
messages: Nucleus
messages: Phosphorylated by pachytene checkpoint kinase IME2, but also phosphorylated in an IME2-independent manner. Phosphorylation probably eliminates SUM1-mediated repression and is also required for full transcriptional activation activity. Phosphorylation of the DNA-binding domain by IME2 does not alter DNA binding affinity.
messages: Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.

559292:YPR046W
gene id: 559292:YPR046W
uniprot id: Q12262
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-H/MCM16 family.
messages: Component of the heterotrimeric kinetochore subcomplex CTF3, which consists of CTF3, MCM16 and MCM22 (PubMed:11782448). The CTF3 subcomplex is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). Interacts with CTF19 (PubMed:11782448).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Nucleus
messages: Present with 279 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YLR052W
gene id: 559292:YLR052W
uniprot id: Q12345
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.
messages: Nucleus
messages: Present with 2300 molecules/cell in log phase SD medium.
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex.

559292:YNL096C
gene id: 559292:YNL096C
uniprot id: P48164
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS7 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). Interacts with snoRNA U3. uS11 interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 43500 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS7 in yeast.
messages: nucleolus

559292:YDR399W
gene id: 559292:YDR399W
uniprot id: Q04178
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
messages: Cytoplasm
messages: Dimer.
messages: Nucleus
messages: Present with 36500 molecules/cell in log phase SD medium.
messages: Subject to feedback inhibition by GMP.
messages: The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.

559292:YOR034C
gene id: 559292:YOR034C
uniprot id: Q12013
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: It is uncertain whether Met-1 or Met-4 is the initiator.
messages: May be involved in constitutive endocytosis of a-factor receptor STE3.
messages: Membrane
messages: Present with 815 molecules/cell in log phase SD medium.
messages: The DHHC domain is required for palmitoyltransferase activity.

559292:YGR191W
gene id: 559292:YGR191W
uniprot id: P06775
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: High-affinity permease for histidine.
messages: Membrane
messages: Present with 688 molecules/cell in log phase SD medium.

559292:YMR255W
gene id: 559292:YMR255W
uniprot id: Q04839
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: High-copy suppressor of mutant alleles of ATP-dependent RNA helicase DBP5, which is involved in mRNA export from the nucleus. It may also play an important role in a late stage of NAB2-mRNA export.
messages: Interacts with GLE1, NUP42, NAB2, ZDS1 and probably DBP5. Forms a complex with GLE1 and NAB2.
messages: Nucleus membrane
messages: Present with 2733 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YMR257C
gene id: 559292:YMR257C
uniprot id: P08468
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Mitochondrion matrix
messages: Present with 538 molecules/cell in log phase SD medium.
messages: Required for translation of the mitochondrial gene for cytochrome c oxidase subunit II (COX2).
messages: To yeast YHR160C.

559292:YLR226W
gene id: 559292:YLR226W
uniprot id: Q05949
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUR kinase complex composed of SGV1/BUR1 and BUR2. Interacts with SGV1.
messages: Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates 'Ser-120' of the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B, the localization of the PAF1 complex to the chromatin, and the silencing of telomeric-associated genes. Also required for histone H3 'Lys-4' trimethylation. May phosphorylate the 'Ser-5' of the RBP1 carboxy-terminal domain (CTD) repeats. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. Also required for vegetative growth itself. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation.
messages: Nucleus
messages: Present with 2910 molecules/cell in log phase SD medium.

559292:YOR264W
gene id: 559292:YOR264W
uniprot id: Q08729
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Bud neck
messages: Expressed in daughter cells.
messages: Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5.
messages: May be involved in the establishment of the daughter fate.
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YNR011C
gene id: 559292:YNR011C
uniprot id: P20095
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Interacts directly with pre-mRNA. According to PubMed:2251118, associated with spliceosomes prior to and throughout step 1 of the splicing reaction. According to PubMed:8943336, it leaves the spliceosome before reaction 1. Interacts with SPP2.
messages: Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing. Capable of hydrolyzing nucleoside triphosphates in the presence of single-stranded RNAs such as poly(U).
messages: Nucleus
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YIL157C
gene id: 559292:YIL157C
uniprot id: P40452
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA1 family.
messages: Interacts with COX1, COX14, MSS51 and SHY1.
messages: Mitochondrion inner membrane
messages: Present with 1680 molecules/cell in log phase SD medium.
messages: Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors.

559292:YDL160C-A
gene id: 559292:YDL160C-A
uniprot id: Q3E829
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CENP-X/MHF2 family.
messages: DNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (PubMed:20347428). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:22561346).
messages: The MHF histone-fold complex is a heterotetramer of 2 MHF1-MHF2 heterodimers. Together with MPH1/FANCM, forms the FANCM-MHF complex (PubMed:22325783). Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (Probable).

559292:YLR421C
gene id: 559292:YLR421C
uniprot id: O13563
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RPN13 family.
messages: Component of the 19S cap proteasome complex composed of at least RPN1, RPN2, RPN3, RPN4, RPN5, RPN6, RPN7, RPN8, RPN9, RPN10, RPN11, RPN12, RPN13, RPT1, RPT2, RPT3, RPT4, RPT5, and RPT6. The 19S subcomplex associates with the 20S proteasome subcomplex to form the functional 26S proteasome.
messages: Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Cytoplasm
messages: Nucleus
messages: Present with 12200 molecules/cell in log phase SD medium.

559292:YLL050C
gene id: 559292:YLL050C
uniprot id: Q03048
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin-binding proteins ADF family.
messages: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton. In effect, yeast cofilin increases the rate of actin polymerization by making new ends available for actin subunit addition. Such a protein complex is important for the polarized growth of yeast cells.
messages: Cytoplasm
messages: Interacts with actin and AIP1 in a ternary complex.
messages: Nucleus matrix
messages: Present with 19600 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.
messages: cytoskeleton

559292:YOL070C
gene id: 559292:YOL070C
uniprot id: Q08229
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Cytoplasm
messages: Interacts with NAP1 (via the central domain consisting of amino acids 143 to 362). Copurifies with ribosomes.
messages: Phosphorylated by CDC28.
messages: Present with 6490 molecules/cell in log phase SD medium.

559292:YJL074C
gene id: 559292:YJL074C
uniprot id: P47037
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-112 and Lys-113 by ECO1 is important for genome stability and S phase sister chromatid cohesion.
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Chromosome
messages: Cohesin complexes are composed of the SMC1 and SMC3 heterodimer attached via their SMC hinge domain, MCD1/SCC1 which link them, and IRR1/SCC3, which interacts with MCD1. The cohesin complex also interacts with SCC2, which is required for its association with chromosomes.
messages: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Present with 2660 molecules/cell in log phase SD medium.
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable MCD1 protein, forming a ring structure (By similarity).

559292:YJL214W
gene id: 559292:YJL214W
uniprot id: P40886
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Present with 623 molecules/cell in log phase SD medium.
messages: Probable glucose transporter.

559292:YHR108W
gene id: 559292:YHR108W
uniprot id: P38817
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds to ARF1 and ARF2.
messages: May play a role in the regulation of membrane traffic through the trans-Golgi network.
messages: Present with 2270 molecules/cell in log phase SD medium.
messages: trans-Golgi network

559292:YJL186W
gene id: 559292:YJL186W
uniprot id: P46982
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MNN1/MNT family.
messages: Glycosylated.
messages: Interacts with SVP26.
messages: Present with 11400 molecules/cell in log phase SD medium.
messages: Responsible for addition of first and second mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications.
messages: cis-Golgi network

559292:YML056C
gene id: 559292:YML056C
uniprot id: P50094
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Present with 2970 molecules/cell in log phase SD medium.

559292:YLR449W
gene id: 559292:YLR449W
uniprot id: Q06205
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
messages: Binds to histones H3 and H4 (PubMed:16959570). Interacts with NOP53.
messages: Nucleus
messages: PPIase that acts as a histone chaperone (PubMed:14981505, PubMed:16846601). Histone proline isomerase that increases the rate of cis-trans isomerization at 'Pro-17' (H3P16), 'Pro-31' (H3P30) and 'Pro-39 (H3P38) on the histone H3 N-terminal tail (PubMed:16959570, PubMed:23888048). H3P16 and H3P30 are the major proline targets with little activity shown against H3P38 (PubMed:23888048). H3P38 isomerization influences SET2-mediated H3K36 methylation thereby regulating gene expression (PubMed:16959570).
messages: Present with 14100 molecules/cell in log phase SD medium.

559292:YBL093C
gene id: 559292:YBL093C
uniprot id: P25046
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins.
messages: Nucleus
messages: Present with 6116 molecules/cell in log phase SD medium.

559292:YFL007W
gene id: 559292:YFL007W
uniprot id: P43583
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:12973301, colocalizes with nascent proteasome. According to PubMed:15778719, associates with proteasome core particles and also forms a complex with regulatory particle-core particle (RP-CP).
messages: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones following DNA double-strand breaks.
messages: Belongs to the BLM10 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2600 molecules/cell in log phase SD medium.
messages: The YYX motif is required for the association with the proteasome.
messages: The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.

559292:YKL142W
gene id: 559292:YKL142W
uniprot id: P35719
names: Caution
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 1550 molecules/cell in log phase SD medium.
messages: Was originally thought to be a mitochondrial ribosomal protein.

559292:YCR018C
gene id: 559292:YCR018C
uniprot id: P09007
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Plays a direct or indirect role in pre-rRNA processing.
messages: Present with 2100 molecules/cell in log phase SD medium.

559292:YER027C
gene id: 559292:YER027C
uniprot id: Q04739
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Promotes the relocalization of the SNF1 kinase complex to the nucleus upon shift to nonfermentable carbon sources.
messages: Component of the SNF1 kinase complex, a heterotrimeric complex composed of the catalytic alpha subunit SNF1, one of the three related beta subunits SIP1, SIP2 or GAL83, and the regulatory gamma subunit SNF4. The beta subunit serves as a bridge between the catalytic and the regulatory subunit. Interacts (via KIS domain) with SNF1. Interacts (via ASC domain) with SNF4. Interacts with REE1.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by SNF1 in vitro.
messages: Present with 3590 molecules/cell in log phase SD medium.

559292:YBR275C
gene id: 559292:YBR275C
uniprot id: P29539
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIF1 family.
messages: Interacts with RIF2 and RAP1.
messages: Negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends. Recruited to telomeres by interaction with the C-terminus of RAP1, which binds directly to telomeric repeat DNA. This may create a negative feedback loop in which the addition of new telomere repeats creates binding sites for inhibitors of telomere length extension. May also influence the balance of transcriptional silencing at telomeres and the silent mating type locus HMR, which is mediated by SIR (Silent Information Regulator) proteins including SIR3 and SIR4. RIF1 competes with SIR proteins for binding to the C-terminus of RAP1. In the absence of RIF1, a limiting cellular pool of SIR proteins may preferentially associate with RAP1 at sub-telomeric loci, causing enhanced telomeric silencing and attenuated silencing of the HMR locus.
messages: Nucleus
messages: telomere

559292:YLR102C
gene id: 559292:YLR102C
uniprot id: Q12107
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: Cytoplasm
messages: Nucleus
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1.

559292:YMR162C
gene id: 559292:YMR162C
uniprot id: Q12674
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Interacts with YNR048W/CRF1; interaction is required for proper expression and endoplasmic reticulum (ER) export of either partner.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable).
messages: trans-Golgi network membrane

559292:YDL236W
gene id: 559292:YDL236W
uniprot id: P19881
names: Activity Regulation
names: Function
names: Miscellaneous
names: Subunit
messages: Activity enhanced by Mg(2+) ion but inhibited by Ca(2+), Zn(2+) and Be(2+) ions. Inorganic phosphate and ATP are competitive inhibitors, whereas pyrophosphate and AMP have no effect.
messages: Homodimer.
messages: PHO13 is dispensable for vegetative growth and sporulation.
messages: Present with 2980 molecules/cell in log phase SD medium.

559292:YPL178W
gene id: 559292:YPL178W
uniprot id: Q08920
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the CBC complex, which binds co-transcriptionally to the cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of STO1/CBC1 and CBC2 that interacts with capped RNAs. The complex interacts strongly with the importin subunit alpha SRP1. The SRP1-CBC trimer also binds to capped RNAs, but formation of the importin alpha/beta heterodimer upon binding of KAP95 to SRP1 in the cytoplasm causes dissociation of CBC from the RNA. The CBC complex is part of the commitment complex 1 (CC1), binding to the cap of pre-mRNA and interacting with U1 snRNP subunits MUD2 and SNU56. The CBC complex is part of the NRD1 complex, composed of CBC2, NAB1, NRD1, SEN1 and STO1/CBC2. The CBC complex also interacts with NPL3 and eIF4G (TIF4631 and TIF4632).
messages: In contrast to metazoans, where the CBC complex is involved in the nuclear export of capped U snRNAs, it is believed that in yeast, U snRNAs are not exported from the nucleus and U snRNPs are assembled in the nucleus from RNAs and imported proteins.
messages: Nucleus
messages: Present with 6200 molecules/cell in log phase SD medium.
messages: perinuclear region

559292:YAL048C
gene id: 559292:YAL048C
uniprot id: P39722
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Collapsed, globular, or grape-like mitochondria.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (Probable).
messages: Mitochondrion outer membrane

559292:YGR108W
gene id: 559292:YGR108W
uniprot id: P24868
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
messages: Maximally expressed before mitosis. The levels peak late in the G2 phase of the cell cycle and are at a minimum in G1 phase.
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YMR215W
gene id: 559292:YMR215W
uniprot id: Q03655
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Membrane
messages: N-glycosylated.
messages: Present with 16400 molecules/cell in log phase SD medium.
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis (By similarity).
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YDL020C
gene id: 559292:YDL020C
uniprot id: Q03465
names: Caution
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:9512348, it is a component of the 26S proteasome.
messages: Acts as a transcriptional activator of a number of genes encoding proteasomal subunits. Binds to a PACE (proteasome-associated control element) DNA sequence 5'-GGTGGCAAA-3'. Its expression is in turn regulated by the 26S proteasome, thereby providing a negative feedback control mechanism. Required for normal growth at low temperatures.
messages: Mutants grow slowly at low temperatures and show partial mislocalization of nuclear antigens.
messages: Nucleus
messages: Probably interacts with SEC63. Interacts with MUB1, UBR2 and RPN2.
messages: Ubiquitinated by UBR2 in the presence of UBC2; which leads to proteasomal degradation.

559292:YNL192W
gene id: 559292:YNL192W
uniprot id: P08004
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Cell lysis during cytokinesis.
messages: Cell membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (PubMed:2941152). Required for mitotic division septum formation during adverse conditions (PubMed:2523889).
messages: Requires proteolytic activation.

559292:YPR172W
gene id: 559292:YPR172W
uniprot id: Q06608
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YER144C
gene id: 559292:YER144C
uniprot id: P39944
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YLR234W
gene id: 559292:YLR234W
uniprot id: P13099
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Forms a complex with SGS1 and RMI1. Interacts with SGS1.
messages: Present with 468 molecules/cell in log phase SD medium.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Essential for proper chromosome segregation in both meiosis and mitosis. Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA. The TOP3-SGS1 protein complex may function as a eukaryotic reverse gyrase introducing positive supercoils into extrachromosomal ribosomal DNA rings.

559292:YHR082C
gene id: 559292:YHR082C
uniprot id: P38691
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: May act on PRP20.
messages: Nucleus
messages: Phosphorylated by PKA in a TORC1-dependent manner. Phosphorylation at PKA consensus sites RRxS/T decreases upon rapamycin treatment.
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YDL035C
gene id: 559292:YDL035C
uniprot id: Q12361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor GPR1/git3 family.
messages: Cell membrane
messages: Seems to associate with GPA2 and act as G protein-coupled receptor that senses glucose and controls filamentous growth. It acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism.

559292:YEL020W-A
gene id: 559292:YEL020W-A
uniprot id: O74700
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM12 component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM10, it may have a strong structural role.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).

559292:YDR266C
gene id: 559292:YDR266C
uniprot id: Q05580
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the E2 ubiquitin-conjugating enzyme UBC4 and histones H3 and H4.
messages: Present with 1960 molecules/cell in log phase SD medium.
messages: Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.

559292:YPL149W
gene id: 559292:YPL149W
uniprot id: Q12380
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated to ATG12; which is essential for autophagy. Conjugation with ATG12 involves ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme.
messages: Conjugated with ATG12. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. The ATG12-ATG5 conjugate associates also with ATG3.
messages: Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity. Plays a role in the regulation of filamentous growth and chronological longevity.
messages: Preautophagosomal structure membrane
messages: Present with 606 molecules/cell in log phase SD medium.
messages: Small amount of ATG5-ATG12 conjugate is enough to perform normal autophagy.

559292:YMR242C
gene id: 559292:YMR242C
uniprot id: P0CX23
uniprot id: P0CX24
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eL20 forms multiple interactions with RNA and proteins in the central protuberance, connecting components of core functional centers that are locatzed far apart (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 54300 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL20 in yeast.

559292:YHL032C
gene id: 559292:YHL032C
uniprot id: P32190
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

559292:YOL148C
gene id: 559292:YOL148C
uniprot id: P50875
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT20 family.
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. SUS1 associates with the SAC3-THP1 complex. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9. Component of the ADA/GCN5 complex that consists of HFI1/ADA1, ADA2, ADA3, SPT20/ADA5 and GCN5 and is probably a subcomplex of SAGA.
messages: Nucleus
messages: Present with 4150 molecules/cell in log phase SD medium.
messages: Transcription regulator. May recruit TATA binding protein (TBP) and possibly other basal factors to bind to the TATA box. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.

559292:YER074W-A
gene id: 559292:YER074W-A
uniprot id: Q3E834
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YOS1 family.
messages: Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for protein transport between endoplasmic reticulum and Golgi apparatus.

559292:YDR524C
gene id: 559292:YDR524C
uniprot id: Q04412
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein (GAP) for the ADP ribosylation factors ARF1 and ARF2. May be involved in the endocytic pathway.
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YKL101W
gene id: 559292:YKL101W
uniprot id: P34244
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Bud neck

559292:YPL050C
gene id: 559292:YPL050C
uniprot id: P39107
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANP1/MMN9/VAN1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Present with 1630 molecules/cell in log phase SD medium.
messages: The M-Pol I and M-Pol II complexes possess alpha-1,6-mannosyltransferase activity and are probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins. May also provide alpha-1,2-mannosyltransferase activity to the M-Pol I complex.
messages: The M-Pol I complex contains MNN9 and VAN1. The M-Pol II complex is composed of ANP1, MNN9, MNN10, MNN11 and HOC1.

559292:YJR130C
gene id: 559292:YJR130C
uniprot id: P47164
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the trans-sulfuration enzymes family. MET7 subfamily.
messages: Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
messages: Cytoplasm
messages: Leads to a clear growth defect on medium containing cysteine or glutathione as sole sulfur source.
messages: Nucleus
messages: Present with 2070 molecules/cell in log phase SD medium.

559292:YJL050W
gene id: 559292:YJL050W
uniprot id: P47047
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase required for the 3'-end formation of 5.8S RNA. Cofactor for the exosome complex that unwinds secondary structure in pre-rRNA. Required for nucleocytoplasmic transport of mRNA. May serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export. Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Component of the TRAMP complex (also called TRF4 complex) composed of at least HUL4, MTR4, PAP2/TRF4 and either AIR1 or AIR2.
messages: Nucleus
messages: Present with 12500 molecules/cell in log phase SD medium.

559292:YFL008W
gene id: 559292:YFL008W
uniprot id: P32908
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Cohesin complexes are composed of the SMC1 and SMC3 heterodimer attached via their SMC hinge domain, MCD1/SCC1 which link them, and IRR1/SCC3, which interacts with MCD1. The cohesin complex also interacts with SCC2, which is required for its association with chromosomes.
messages: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Present with 5710 molecules/cell in log phase SD medium.
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable MCD1 protein, forming a ring structure.

559292:YER066W
gene id: 559292:YER066W
uniprot id: P40042
names: Function
messages: May be involved in the modulation of rDNA transcription.

559292:YLR007W
gene id: 559292:YLR007W
uniprot id: Q07913
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6. Interacts with SMC5 and SMC6. Interacts with NSE3.
messages: Nucleus

559292:YGL018C
gene id: 559292:YGL018C
uniprot id: P53193
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Stimulates the ATPase activity of its specialized Hsp70 chaperone partner SSQ1, to mediate the transfer of iron-sulfur clusters from ISU1 to GRX5. Binds to the substrate protein ISU1 and targets it to SSQ1.
messages: Increases association between GRX5 and SSQ1 (PubMed:23615440). Inviable vegetative cell population growth (PubMed:26545917).
messages: Interacts with ISU1 and SSQ1.
messages: Mitochondrion matrix
messages: Present with 2010 molecules/cell in log phase SD medium.

559292:YDR410C
gene id: 559292:YDR410C
uniprot id: P32584
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in A-factor mating pheromone and Ras proteins (PubMed:8289819, PubMed:11451995, PubMed:15611058). Does not have a preference for the farnesyl or geranylgeranyl moieties in the model substrates N-acetyl-S-farnesyl-L-cysteine (AFC) and N-acetyl-S-geranylgeranyl-L-cysteine (AGGC) in vitro (PubMed:15611058).
messages: Present with 2690 molecules/cell in log phase SD medium.

559292:YJR062C
gene id: 559292:YJR062C
uniprot id: P40354
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.
messages: Deamidates N-terminal Asn and Gln. Component of a targeting complex in the N-end rule pathway.
messages: It is uncertain whether Met-1 or Met-11 is the initiator.
messages: Present with 1640 molecules/cell in log phase SD medium.

559292:YOR185C
gene id: 559292:YOR185C
uniprot id: P32836
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity).
messages: GSP2 expression exhibits carbon source dependency.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Not essential for cell viability.
messages: Nucleus
messages: Present with 2460 molecules/cell in log phase SD medium.

559292:YBR044C
gene id: 559292:YBR044C
uniprot id: P38228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Chaperone. Required for the assembly of succinate dehydrogenase subunits. Ensures mitochondrial gene expression at elevated temperatures and prevents heat-aggregation of the ribosomal subunit VAR1.
messages: Forms a high molecular mass protein complex of approximately 850 kDa.
messages: Mitochondrion inner membrane

559292:YBL084C
gene id: 559292:YBL084C
uniprot id: P38042
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC3/CDC27 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by CDC28, which is required for the early mitotic activity of the APC/C in its CDC20-bound form.
messages: Present with 593 molecules/cell in log phase SD medium.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1.

559292:YDR198C
gene id: 559292:YDR198C
uniprot id: Q03942
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM2 family.
messages: Present with 768 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates 60S ribosomal protein L12 (RPL12A and RPL12B) at 'Lys-4' and 'Lys-11'.

559292:YER078C
gene id: 559292:YER078C
uniprot id: P40051
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome.
messages: Belongs to the peptidase M24B family.
messages: Binds 2 manganese ions per subunit.
messages: Mitochondrion inner membrane
messages: Nucleus
messages: Present with 5080 molecules/cell in log phase SD medium.

559292:YDR121W
gene id: 559292:YDR121W
uniprot id: Q04603
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. Also functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex.
messages: DNA polymerase epsilon is a heterotetramer consisting of POL2, DPB2, DPB3 and DPB4. Component of the ISW2 complex, which at least consists of ISW2, ITC1, DLS1 and DPB4.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus
messages: Present with 2100 molecules/cell in log phase SD medium.

559292:YIR028W
gene id: 559292:YIR028W
uniprot id: Q04895
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane
messages: Transport of allantoin.

559292:YER038W-A
gene id: 559292:YER038W-A
uniprot id: A0A023PZB3
names: Subcellular Location Annotation
messages: Mitochondrion

559292:YHR149C
gene id: 559292:YHR149C
uniprot id: P32900
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKG6/TOS2 family.
messages: Interacts with ZDS1 and ZDS2.
messages: May be involved in the polarity establishment process. Suppresses the lethality of KEX2-GAS1 double null mutant when overexpressed.
messages: Membrane
messages: Phosphorylated by CDC28.
messages: Present with 1550 molecules/cell in log phase SD medium.

559292:YCR023C
gene id: 559292:YCR023C
uniprot id: P25351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

559292:YOR243C
gene id: 559292:YOR243C
uniprot id: Q08647
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase TruD family.
messages: Catalyzes pseudouridylation at position 35 in U2 snRNA stem-loop II region which induces particular conformation of the mRNA-U2 snRNA duplex and places the nucleophile in an accessible position for the first step of splicing (PubMed:12426583, PubMed:12682021, PubMed:15611063, PubMed:18435545, PubMed:19114708, PubMed:25219674). Also catalyzes pseudouridylation at position 56 in U2 snRNA (PubMed:21131909). Catalyzes also pseudouridylation at position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr) (PubMed:14561887, PubMed:18332121, PubMed:25219674, PubMed:35058356). Pseudouridine residues in tRNAs may stabilize the local RNA conformation, favor interactions with protein partners and play an important role in the stabilization of the codon-anticodon interaction with mRNA (PubMed:14561887). Also catalyzes pseudouridylation of mRNAs in response to heat shock: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAR-3' (PubMed:25219674, PubMed:35058356).
messages: Cytoplasm
messages: Decreased level of pseudouridylated mRNAs.
messages: Nucleus
messages: Present with 4150 molecules/cell in log phase SD medium.

559292:YGR239C
gene id: 559292:YGR239C
uniprot id: P50091
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-21 family.
messages: Interacts with PEX7 (PubMed:12167700, PubMed:9864360, PubMed:23812376, PubMed:11606420). Interacts with PEX13 (PubMed:12167700). Interacts with SES1 (PubMed:12204379, PubMed:17451428).
messages: Monoubiquitinated at Cys-5; acts as a signal for PEX21 extraction and is required for proper export from peroxisomes and recycling.
messages: Peroxisome
messages: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:12167700, PubMed:9864360, PubMed:23812376). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (By similarity). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX21 (PubMed:23812376). Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA (PubMed:12204379, PubMed:17451428).
messages: cytosol

559292:YOR355W
gene id: 559292:YOR355W
uniprot id: P41913
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Impairs growth on glycerol carbon source.
messages: Involved in nuclear control of mitochondria.
messages: Present with 2280 molecules/cell in log phase SD medium.

559292:YNR040W
gene id: 559292:YNR040W
uniprot id: P53736
names: Miscellaneous
messages: Present with 1140 molecules/cell in log phase SD medium.

559292:YJL078C
gene id: 559292:YJL078C
uniprot id: P47033
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: Expressed specifically in daughter cells through activation by the transcription factor ACE2. STE12 represses expression of the full-length transcript and induces expression of the short form. STE12-binding to pheromone response elements (PREs) at positions -175 and -161 prevents SPT15 from binding TATA-box 1 and thus it binds TATA-box 2 at position +385 and directs internal transcription initiation at position +452.
messages: Membrane
messages: Produced by alternative promoter usage.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The full-length isoform (isoform Long) is a daughter cell-specific cell wall protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds. Involved in tolerance to organic solvents such as dimethyl sulfoxide (DMSO). Also plays a role as an inhibitor of mating. STE12 is utilized as a repressor of full-length PRY3 transcription, ensuring efficient mating.
messages: There is no evidence that production of the short PRY3 transcript (isoform Short) is anything more than an adventitious by-product of the mechanism responsible for the repression of the full-length transcript. Moreover, no disadvantage is detectable for cells unable to make the short transcript (PubMed:16940175).
messages: cell wall

559292:YKL051W
gene id: 559292:YKL051W
uniprot id: P35735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFK1 family.
messages: Cell membrane
messages: May control the production of phosphatidylinositol 4-phosphate (PI4P) by the STT4 PI 4-kinase. Mediates proper localization of STT4 to the plasma membrane.

559292:YIL001W
gene id: 559292:YIL001W
uniprot id: P40560
names: Miscellaneous
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YML128C
gene id: 559292:YML128C
uniprot id: Q03104
names: Miscellaneous
messages: Originally MSC1 was identified in a screen for mutants that show an increase in meiotic unequal sister-chromatid recombination (SCR).
messages: Present with 1070 molecules/cell in log phase SD medium.

559292:YMR205C
gene id: 559292:YMR205C
uniprot id: P16862
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.
messages: Mitochondrion outer membrane
messages: Present with 90200 molecules/cell in log phase SD medium.

559292:YBR244W
gene id: 559292:YBR244W
uniprot id: P38143
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: By oxidative stress, dependent on transcription factor YAP1 (PubMed:10480913). By oleic acid (PubMed:21763276).
messages: Cytoplasm
messages: Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress (PubMed:10480913, PubMed:11445588). Plays an important role in the oxidative stress-induced response in the presence of Ca(2+). Has peroxidase activity using preferentially thioredoxin as a reducing power. The redox state of the mitochondrial GPX2 is regulated by TRX1 and TRX2 (cytoplasmic thioredoxin), and by TRX3 (mitochondrial matrix thioredoxin) (PubMed:16251189). Involved in sporulation (PubMed:21763276).
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: Monomer.
messages: Nucleus
messages: Present with 2010 molecules/cell in log phase SD medium.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide.
messages: Was originally thought to be a glutathione peroxidase (PubMed:10480913) or a phospholipid hydroperoxide glutathione peroxidase (PubMed:11445588), but functions as an atypical 2-Cys peroxiredoxin using thioredoxin as reducing power instead (PubMed:16251189).

559292:YIL102C-A
gene id: 559292:YIL102C-A
uniprot id: Q2V2P5
names: Subcellular Location Annotation
messages: Membrane

559292:YBR098W
gene id: 559292:YBR098W
uniprot id: P38257
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EME1/MMS4 family.
messages: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions. Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures. May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover. In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved. Spore formation and viability are severely impaired in deletion strains.
messages: Interacts with MUS81.
messages: Nucleus
messages: Two distinct classes of meiotic crossovers have been demonstrated in budding yeast. Class I crossovers exhibit crossover interference and require MSH4 and MSH5 for their resolution, while class II crossovers exhibit no crossover interference and require MUS81 and MMS4. While class I crossovers represent the majority of crossovers in S.cerevisiae, they are virtually absent in S.pombe which lacks orthologs of MSH4 and MSH5.

559292:YDL073W
gene id: 559292:YDL073W
uniprot id: Q07454
names: Disruption Phenotype
names: Similarity
messages: Belongs to the UPF0592 family.
messages: Cells are viable and do not display any phenotype.

559292:YJR019C
gene id: 559292:YJR019C
uniprot id: P41903
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Contributes to growth on fatty acids.
messages: Belongs to the C/M/P thioester hydrolase family.
messages: Peroxisome
messages: Up-regulated by oleic acid.

559292:YLL053C
gene id: 559292:YLL053C
uniprot id: P0CD98
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Could be the product of a pseudogene. This is the C-terminal part of aquaporin-2. In strain S288c and many laboratory strains, a natural 11 bp deletion in position 109 leads to a frameshift, which disrupts the gene coding for this protein and produces two ORFs YLL052C and YLL053C. A contiguous sequence for aquaporin-2 can be found in strain Sigma 1278B (AC P0CD89).
messages: Membrane

559292:YPL249C
gene id: 559292:YPL249C
uniprot id: Q12344
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GYP5 family.
messages: Bud
messages: Bud neck
messages: Cytoplasm
messages: GTPase-activating protein which accelerates the GTP hydrolysis rate of YPT1 and SEC4. Involved in ER to Golgi trafficking and polarized exocytosis.
messages: Interacts with GYL1 and RVS167; and is part of SEC4-containing complexes.
messages: Present with 1940 molecules/cell in log phase SD medium.

559292:YBR214W
gene id: 559292:YBR214W
uniprot id: P38314
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation during budding.
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YOR154W
gene id: 559292:YOR154W
uniprot id: Q12232
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLP1 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with EMP65.
messages: May be involved in membrane protein folding (PubMed:19325107). Required for localization of MPS3 to the nuclear envelope (PubMed:23275891).
messages: Present with 3250 molecules/cell in log phase SD medium.

559292:YPL184C
gene id: 559292:YPL184C
uniprot id: Q08925
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 7950 molecules/cell in log phase SD medium.
messages: RNA-binding protein that binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES). Probably involved in translational regulation.

559292:YMR005W
gene id: 559292:YMR005W
uniprot id: P50105
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF4 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus
messages: Present with 1900 molecules/cell in log phase SD medium.
messages: TAF4 heterodimerizes with TAF12, forming ultimately an octamer consisting of a TAF6/TAF9 heterotetramer core flanked by TAF4/TAF12 dimers on either side, similar to the histone H2A/H2B/H3/H4 octamer. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.

559292:YDR275W
gene id: 559292:YDR275W
uniprot id: Q05611
names: Miscellaneous
names: Subcellular Location Annotation
messages: Lipid droplet
messages: Membrane
messages: Open reading frame exhibits genomic organization compatible with a translational readthrough-dependent mode of expression.
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YNL264C
gene id: 559292:YNL264C
uniprot id: P53844
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Contributes to efficient phospholipase D1 activation and phospholipase B1 inhibition in the regulation of phospholipid turnover. Forms a complex with phosphatidylserine decarboxylase PSD2 that seems essential for maintenance of vacuolar phosphatidylethanolamine (PE) levels (PubMed:20016005).
messages: Interacts with phosphatidylserine decarboxylase PSD2.
messages: Microsome
messages: Present with 5040 molecules/cell in log phase SD medium.

559292:YNL067W
gene id: 559292:YNL067W
uniprot id: P51401
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 76000 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL6 in yeast.

559292:YPL159C
gene id: 559292:YPL159C
uniprot id: Q99373
names: Function
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Required for respiratory growth, stability of the mitochondrial genome and for proper assembly or maintenance of mitochondrial proteins.

559292:YFL068W
gene id: 559292:YFL068W
uniprot id: P0CX99
uniprot id: P0CY00
uniprot id: P0CY01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0479 family.
messages: Membrane

559292:YPR189W
gene id: 559292:YPR189W
uniprot id: P17883
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SKI complex composed of at least SKI2, SKI3 and SKI8. The SKI complex interacts with SKI7, which makes the link between the SKI complex and the exosome in order to perform mRNA degradation.
messages: Component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon.
messages: Cytoplasm
messages: Nucleus
messages: Present with 11900 molecules/cell in log phase SD medium.

559292:YDL199C
gene id: 559292:YDL199C
uniprot id: Q12407
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

559292:YOR251C
gene id: 559292:YOR251C
uniprot id: Q08686
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
messages: Cytoplasm
messages: Mitochondrion
messages: Present with 5770 molecules/cell in log phase SD medium.
messages: Required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs.

559292:YDL025C
gene id: 559292:YDL025C
uniprot id: Q12100
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: By the alkylating agent methyl methanesulfonate (MMS).
messages: Interacts with ribosome biogenesis factors ARC1, CKA2 and GUS1.
messages: Present with 861 molecules/cell in log phase SD medium.
messages: Probable serine/threonine-protein kinase that may be involved in ribosome biogenesis.

559292:YOR270C
gene id: 559292:YOR270C
uniprot id: P32563
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Glycosylated.
messages: Present with 55714 molecules/cell in log phase SD medium.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1491220, PubMed:8798414, PubMed:11278748). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1491220, PubMed:11278748). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:8798414, PubMed:11278748).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

559292:YAL010C
gene id: 559292:YAL010C
uniprot id: P18409
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM10 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex, which consists of SAM35, SAM37 and SAM50, to form a SAM(holo) complex.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane
messages: Present with 768 molecules/cell in log phase SD medium.

559292:YBR108W
gene id: 559292:YBR108W
uniprot id: P38266
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AIM3 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Interacts with RVS167.
messages: Membrane raft

559292:YPL109C
gene id: 559292:YPL109C
uniprot id: Q02981
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Mitochondrion
messages: Present with 2470 molecules/cell in log phase SD medium.

559292:YDR522C
gene id: 559292:YDR522C
uniprot id: P08459
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Involved in middle stages of meiosis. Redundant with SPS22 for the organization of the beta-glucan layer of the spore wall.
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YJL020C
gene id: 559292:YJL020C
uniprot id: P47068
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to the SH3 domains of the type I myosins MYO3 and MYO5.
messages: Involved in the regulation of actin cytoskeleton.
messages: actin patch

559292:YKR037C
gene id: 559292:YKR037C
uniprot id: P36131
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex SPC34 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle

559292:YMR041C
gene id: 559292:YMR041C
uniprot id: Q04212
names: Similarity
messages: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

559292:YOL132W
gene id: 559292:YOL132W
uniprot id: Q08271
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Expressed exclusively during sporulation (at protein level).
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly.

559292:YMR069W
gene id: 559292:YMR069W
uniprot id: Q04751
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A.
messages: Nucleus

559292:YLR229C
gene id: 559292:YLR229C
uniprot id: P19073
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Interacts with BEM4; the interaction is direct (PubMed:8754839). Interacts with AXL2 (PubMed:17460121). Interacts with RGA1 (PubMed:7498791).
messages: Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. Affects signaling in the pheromone-response pathway through the STE20 protein kinase. Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4.

559292:YOR058C
gene id: 559292:YOR058C
uniprot id: P50275
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAP65/ASE1 family.
messages: Interacts with CDC48; the interaction is likely to result in CDC5 degradation.
messages: Present with 556 molecules/cell in log phase SD medium.
messages: Required for anaphase spindle elongation.
messages: spindle

559292:YKL197C
gene id: 559292:YKL197C
uniprot id: P24004
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AAA-cassette D1 is required for interaction with PEX6. ATP-binding in AAA-cassette D2 is required for interaction with PEX6. ATP-binding and hydrolysis in AAA-cassette D2 is required for proper function in PEX5 dislocation.
messages: Belongs to the AAA ATPase family.
messages: By oleate.
messages: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:15634331, PubMed:16007078, PubMed:16911527, PubMed:26170309, PubMed:26066397, PubMed:29321502). Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:26170309, PubMed:26066397, PubMed:29321502). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29321502).
messages: Interacts with PEX6; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers (PubMed:15634331, PubMed:16007078, PubMed:26170309, PubMed:26066397, PubMed:29321502). The PEX1-PEX6 heterooligomers associate with the peroxisomal importomer via interaction of PEX6 with the peroxisomal membrane anchor PEX15 (PubMed:16911527).
messages: Peroxisome membrane
messages: Present with 2100 molecules/cell in log phase SD medium.
messages: cytosol

559292:Q0080
gene id: 559292:Q0080
uniprot id: P00856
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane

559292:YKL082C
gene id: 559292:YKL082C
uniprot id: P36080
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SURF6 family.
messages: Component of the 90S and 60S pre-ribosomal particles.
messages: Involved in ribosome biogenesis and cell polarity. Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis.
messages: nucleolus

559292:YOR123C
gene id: 559292:YOR123C
uniprot id: P38439
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LEO1 family.
messages: Component of the PAF1 complex which consists of at least CDC73, CTR9, LEO1, PAF1 and RTF1.
messages: Present with 1110 molecules/cell in log phase SD medium.
messages: The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.
messages: nucleoplasm

559292:YOR044W
gene id: 559292:YOR044W
uniprot id: Q08416
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Between 15 and 30 minutes due to fermentation progress.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.
messages: Endoplasmic reticulum membrane
messages: Is probably involved in a pathway contributing to genomic integrity.
messages: Present with 4280 molecules/cell in log phase SD medium.

559292:YNL279W
gene id: 559292:YNL279W
uniprot id: P53835
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM1 family.
messages: By pheromones during mating, through the regulation by the STE12 transcription factor. Also induced in respiratory-deficient cells.
messages: Cell membrane
messages: Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.

559292:YIL009W
gene id: 559292:YIL009W
uniprot id: P39002
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates endogenous long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:8206942). Acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10 (PubMed:8206942).
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Cell membrane
messages: Interacts with FRK1.
messages: Present with 6440 molecules/cell in log phase SD medium.
messages: The FACS motif is required for catalytic activity and substrate specificity.

559292:YDR330W
gene id: 559292:YDR330W
uniprot id: Q06682
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with CDC48.
messages: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
messages: Nucleus
messages: Present with 6630 molecules/cell in log phase SD medium.

559292:YGL139W
gene id: 559292:YGL139W
uniprot id: P53121
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Endoplasmic reticulum membrane
messages: May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.

559292:YPL137C
gene id: 559292:YPL137C
uniprot id: Q03016
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GIP3/HER1 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Interacts with phosphatase 1 (GLC7).
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YMR131C
gene id: 559292:YMR131C
uniprot id: Q04225
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with ribosomal protein L3.
messages: Involved in regulation of L3 expression and stability and plays a role in early 60S ribosomal subunit assembly. May be required for proper assembly of pre-ribosomal particles during early ribosome biogenesis, presumably by targeting L3 onto the 35S precursor rRNA.
messages: Nucleus

559292:YDR446W
gene id: 559292:YDR446W
uniprot id: Q04110
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CDC6.
messages: May be involved in cell wall organization and biogenesis.
messages: Nucleus

559292:YAR014C
gene id: 559292:YAR014C
uniprot id: P27637
names: Function
names: Miscellaneous
names: Subunit
messages: Important for bud site selection. Seems to be a regulatory subunit of the BUD14-GLC7 type-I phosphatase complex. The BUD14-GLC7 complex is necessary to regulate microtubule dynamics at the cortex and may function as a specific activator of the dynein complex.
messages: Interacts with GLC7.
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YBR282W
gene id: 559292:YBR282W
uniprot id: P36526
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 2250 molecules/cell in log phase SD medium.

559292:YJL001W
gene id: 559292:YJL001W
uniprot id: P38624
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 7250 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. PRE3 and PRE4 are necessary for the peptidyl-glutamyl-peptide-hydrolyzing activity.
messages: The side chain of Thr-20 acts as nucleophile, and the N-terminal amino group acts as proton acceptor.
messages: This subunit is necessary for the peptidylglutamyl-peptide hydrolyzing activity.

559292:YDL160C
gene id: 559292:YDL160C
uniprot id: P39517
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1 (PubMed:11780629, PubMed:12032091, PubMed:11696541, PubMed:12730603, PubMed:15703442. PubMed:15706350). Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs (PubMed:15166134). May also have a role in translation and mRNA nuclear export (PubMed:12930949). Required for sporulation (PubMed:12930949). Blocks autophagy in nutrient-rich conditions by, at least partly, binding and repressing the expression of a set of ATG genes, including ATG3, ATG7, ATG8, ATG19, ATG20, ATG22 and SNX4/ATG24 (PubMed:26098573).
messages: Associated with the CCR4-NOT complex and possibly other big complexes (PubMed:9504907, PubMed:12930949). Interacts with CDC39/NOT1 (PubMed:11696541). Interacts with DCP1, LSM1, and POP2 (PubMed:9504907, PubMed:11780629). Interacts with IGO1 (PubMed:20471941). Interacts with PAT1 and with KEM1, the major 5'-3' exonuclease (PubMed:11780629, PubMed:12032091).
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: Leads to an increased in autophagy flux (PubMed:26098573). Causes an accumulation of ATG3, ATG7, ATG8, ATG19, ATG20, ATG22 and SNX4/ATG24 transcripts in nutrient-replete conditions (PubMed:26098573).
messages: P-body
messages: Present with 42900 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

559292:YMR144W
gene id: 559292:YMR144W
uniprot id: P40214
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subunit
messages: In concert with FKH1, plays a role in directionality of mating type switching by controlling which donor mating-type locus is inserted into MAT locus during mating type switching.
messages: Interacts with FKH1.
messages: Leads to a defect in donor preference during mating-type switching (PubMed:27257873). Does not affect FKH1's overlapping role with FKH2 of regulation of the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle (PubMed:27257873).
messages: Present with 2120 molecules/cell in log phase SD medium.

559292:YML130C
gene id: 559292:YML130C
uniprot id: Q03103
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: By unfolded protein response (UPR).
messages: Endoplasmic reticulum membrane
messages: Enzyme activity is tightly regulated to prevent the accumulation of reactive oxygen species in the endoplasmic reticulum. Reversibly down-regulated by the formation of disulfide bonds between Cys-150 and Cys-295.
messages: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Also able to oxidize directly the PDI related protein MPD2. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI1 and related proteins. Reoxidation of ERO1 probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress.
messages: May function both as a monomer and a homodimer.
messages: N-glycosylated.
messages: The C-terminal part (437-563) is required for the association with the endoplasmic reticulum lumen membrane.
messages: The Cys-100/Cys-105 and Cys-352/Cys-355 disulfide bonds constitute the redox-active center. The Cys-100/Cys-105 disulfide bond may accept electron from PDI1 and funnel them to the active site disulfide Cys-352/Cys-355.

559292:YER038C
gene id: 559292:YER038C
uniprot id: P40026
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6. Interacts with NSE5.
messages: Cytoplasm
messages: Nucleus

559292:YKL073W
gene id: 559292:YKL073W
uniprot id: P36016
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: By the unfolded protein response (UPR).
messages: Chaperone required for protein translocation and folding in the endoplasmic reticulum.
messages: Endoplasmic reticulum lumen
messages: Interacts with the heat shock protein 70 (HSP70) KAR2, and this stimulates nucleotide exchange on KAR2. KAR2 in turn acts to stimulate the ATPase activity of LHS1.
messages: N-glycosylated.
messages: Present with 137 molecules/cell in log phase SD medium.

559292:YBL071C
gene id: 559292:YBL071C
uniprot id: P38185
names: Subcellular Location Annotation
messages: Membrane

559292:YNR075W
gene id: 559292:YNR075W
uniprot id: P52924
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Membrane
messages: Present with 2370 molecules/cell in log phase SD medium.

559292:YOR166C
gene id: 559292:YOR166C
uniprot id: Q12104
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWT1 family.
messages: Deletion causes a slow growth phenotype on synthetic medium at 37 degrees Celsius and leads to decreased transcription. Deletion has no effect on ribosome biogenesis or frequency of recombination. Deletion is synthetically lethal with a deletion of each of the THO complex subunits HPR1, MFT1, THO2, and THP2.
messages: Interacts with the TREX complex and RNA polymerase II.
messages: Involved in transcription. Probably functions as a transcriptional activator.
messages: Nucleus

559292:YHL028W
gene id: 559292:YHL028W
uniprot id: P38739
names: Subcellular Location Annotation
messages: Membrane

559292:YNL076W
gene id: 559292:YNL076W
uniprot id: P34072
names: Function
names: Subcellular Location Annotation
messages: Negative regulator of Ras-cAMP pathway. Involved in transcriptional regulation of galactose-inducible genes.
messages: Nucleus

559292:YJL059W
gene id: 559292:YJL059W
uniprot id: P47040
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Plays a role in vacuolar arginine transport. Involved in pH homeostasis. May be involved in ion homeostasis together with IST2. Not necessary for mitochondrial function or ATP synthase degradation.
messages: Vacuole membrane

559292:YCR071C
gene id: 559292:YCR071C
uniprot id: P25642
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 1700 molecules/cell in log phase SD medium.

559292:YDL051W
gene id: 559292:YDL051W
uniprot id: P33399
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SXM1.
messages: Molecular chaperone that binds nascent RNA polymerase III transcripts, stabilizing these RNAs against exonucleases. Required for the 3' endonucleolytic cleavage that matures tRNA precursors and for efficient folding of certain pre-tRNAs. Cooperates with GCD14 in the maturation of a subset of RNA polymerase III transcripts. Functions also in the assembly of certain RNA polymerase II-transcribed RNAs into RNPs. Binds and stabilizes newly synthesized U6 snRNA as well as precursors of U3 snRNA from degradation. Facilitates efficient Sm protein binding, thus assisting formation of the U4/U6 snRNP. Required for Ty3 normal transposition frequency.
messages: Nucleus
messages: Phosphorylation is not required for the roles tRNA and snRNP biogenesis.

559292:YER074W
gene id: 559292:YER074W
uniprot id: P0CX31
uniprot id: P0CX32
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA. Also partially acetylated by NatC.
messages: Present with 6160 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS24 in yeast.

559292:YIL069C
gene id: 559292:YIL069C
uniprot id: P0CX31
uniprot id: P0CX32
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA. Also partially acetylated by NatC.
messages: Present with 6160 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS24 in yeast.

559292:YOR008C-A
gene id: 559292:YOR008C-A
uniprot id: Q3E7B9
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of telomere length.
messages: Membrane

559292:YKL207W
gene id: 559292:YKL207W
uniprot id: P36039
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).

559292:YMR244W
gene id: 559292:YMR244W
uniprot id: Q04018
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUN family.
messages: Membrane

559292:YBR231C
gene id: 559292:YBR231C
uniprot id: P38326
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC5 family.
messages: Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.
messages: Nucleus
messages: Present with 1680 molecules/cell in log phase SD medium.

559292:YNL044W
gene id: 559292:YNL044W
uniprot id: P53633
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Golgi apparatus membrane
messages: Interacts with YIP1 and the Rab GTPases SEC4, YPT1, YPT6, YPT10, YPT11, YPT31, YPT32 and YPT52.
messages: Present with 5500 molecules/cell in log phase SD medium.

559292:YMR304W
gene id: 559292:YMR304W
uniprot id: P50101
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Cells show oxidative stress-related import deficiencies and growth defect on oleic acid (PubMed:21665945). Peroxisomes are clustered (PubMed:21665945). Cells display defects in peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:21665945).
messages: Deubiquitinase involved in peroxisome import by mediating deubiquitination of the peroxisomal import receptor PEX5 (PubMed:21665945). Catalyzes deubiquitination of both monoubiquitiated and polyubiquitinated forms of PEX5 following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:21665945).
messages: Interacts with PEX6; promoting association with the PEX1-PEX6 ATPase complex.
messages: Peroxisome
messages: Present with 2810 molecules/cell in log phase SD medium.
messages: cytosol

559292:YGR125W
gene id: 559292:YGR125W
uniprot id: P53273
names: Miscellaneous
names: Subcellular Location Annotation
messages: Present with 1420 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YLR342W
gene id: 559292:YLR342W
uniprot id: P38631
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS) complex. Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall. Involved in cell wall synthesis, maintenance and remodeling.
messages: Belongs to the glycosyltransferase 48 family.
messages: Cell membrane
messages: Cells are hypersensitive to immunosuppressant drugs FK506 and cyclosporin A (CsA) due to the inhibition of calcineurin phosphatase activity by the receptor-drug complexes and is dependent on calcineurin for vegetative growth. It confers a slow growth phenotype which is partially suppressed by exogenously added Ca(2+) and exacerbated by EGTA. Simultaneous disruption of CNA1 and CNA2 or CNB1 is lethal in FKS1-1. Disruption of FPR1 or CPR1 results in the loss of hypersensitivity. Overexpression of CNA1 or CNA2, in conjunction with CNB1, results in a significant decrease in hypersensitivity to FK506 and CsA. FKS1-8 mutant is sensitive to FK506 and cyclosporin A, has increased tendency to lyse and exhibits slow growth that is improved by the addition of osmotic stabilizing agents. It is more sensitive to the drugs when grown on galactose compared to dextrose. ETG1-1 mutant is resistant to the cell wall active echinocandins, which are inhibitors of 1,3-beta-D-glucan synthase. ETG1-4 mutant is hypersensitive to the chitin synthase inhibitor nikkomycin Z. Deletion of FKS1 leads to hypersensitivity to echinocandin-like antifungal lipopeptide caspofungin, a 1,3-beta-glucan synthase inhibitor. Deletion mutant also displays a 30% reduction in 1,3-beta-glucan and 15% reduction in alkali-insoluble 1,6-beta-glucan compared to wild-type. Increases cellular chitin level (PubMed:17142567). Increases chitin chain length (PubMed:17142567).
messages: Component of the 1,3-beta-glucan synthase (GS) complex, composed of two alternate catalytic subunits FKS1 or GSC2, and a regulatory subunit RHO1. Interacts with RHO1, which is a GTP-binding protein.
messages: During vegetative growth. Expressed periodically during the cell cycle.
messages: Mitochondrion

559292:YOL141W
gene id: 559292:YOL141W
uniprot id: Q08282
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Cytoplasm
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the final 2 independent reactions, methylation of the alpha-carboxy group of wybutosine-72 to form wybutosine-58, and methoxycarbonylation of alpha-amino group of wybutosine-58 through the fixation of CO(2) to complete wybutosine.

559292:YDR434W
gene id: 559292:YDR434W
uniprot id: Q04080
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGS family.
messages: Component of the GPI transamidase complex. Involved in transfer of GPI to proteins.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with CDC91, GPI16, GPI8 and GAA1.
messages: N-glycosylated.
messages: Present with 7520 molecules/cell in log phase SD medium.

559292:YJR025C
gene id: 559292:YJR025C
uniprot id: P47096
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 2330 molecules/cell in log phase SD medium.

559292:YMR290C
gene id: 559292:YMR290C
uniprot id: Q03532
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: Interacts with RRP1. Associates in the nucleolus with the 60S and pre-60S ribosomal subunits. It has also been isolated with the nuclear pore complex.
messages: Phosphorylated by CDK1.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: Transcription depends partially on SET1.
messages: nucleolus

559292:YER075C
gene id: 559292:YER075C
uniprot id: P40048
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Cytoplasm
messages: Interacts with HOG1.
messages: Major phosphatase responsible for tyrosine dephosphorylation of MAP kinases FUS3 and HOG1 to inactivate their activity; it also has important roles, along with MSG5, in the inactivation of FUS3 following pheromone stimulation.
messages: Present with 768 molecules/cell in log phase SD medium.

559292:YER081W
gene id: 559292:YER081W
uniprot id: P40054
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
messages: Present with 7670 molecules/cell in log phase SD medium.

559292:YPL173W
gene id: 559292:YPL173W
uniprot id: P36534
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uL24m forms the wall of the exit tunnel.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

559292:YIR019C
gene id: 559292:YIR019C
uniprot id: P08640
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A soluble form is probably produced by proteolytic cleavage at the cell surface (shedding).
messages: Belongs to the flocculin family. Highly divergent.
messages: Extensively O-mannosylated.
messages: Homophilic binding protein that enables kin discrimination in heterogeneous yeast populations by mediating homotypic cell-cell interactions during flocculation, a reversible and asexual process in which cells adhere to form aggregates (flocs) (PubMed:32286952, PubMed:25960408, PubMed:27547826, PubMed:17921350, PubMed:22129043). Plays a role in cell-substrate adhesion, haploid invasive growth, diploid pseudohyphae formation and biofilm (flor) development (PubMed:18001350, PubMed:11027318, PubMed:11157168, PubMed:16043420, PubMed:17921350, PubMed:20619652, PubMed:8710886, PubMed:8955395). Adhesive activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose (PubMed:16043420, PubMed:22129043).
messages: In the reference strain S288C, the transcriptional activator FLO8 contains an internal in-frame stop codon, leading to impaired FLO11 expression in this strain.
messages: Membrane
messages: The Flo11 domain contains aromatic residues that form two hydrophobic bands on the surface of the protein that confer homophilic binding (PubMed:32286952, PubMed:25960408, PubMed:22129043). The hydrophobic bands are lined by stretches of acidic residues that may sensitise the protein to environmental pH (PubMed:25960408). The domain is required for biofilm formation (PubMed:25960408). The domain does not interact with mannose or calcium ions (PubMed:22129043, PubMed:25960408).
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains. There is a linear correlation between protein size and the extend of adhesion: the more repeats, the stronger the adhesion properties and the greater the fraction of flocculating cells (By similarity).
messages: cell wall

559292:YBL074C
gene id: 559292:YBL074C
uniprot id: P32357
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth.
messages: Cytoplasm
messages: Heterodimer (Probable). Interacts with PRP8 (via RNase H homology domain and MPN domain), competing with BRR2 for the same binding site. Component of a U5 snRNP complex that contains at least the U5 snRNA, PRP8, SNU114, AAR2, SMB1, SMD1, SMD2, SMD3, SME1, SMX2 and SMX3, but is not a component of the U4/U6-U5 tri-snRNP complex.
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues.
messages: Present with 7330 molecules/cell in log phase SD medium.

559292:YMR039C
gene id: 559292:YMR039C
uniprot id: P54000
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: Nucleus
messages: Plays a role in the release of TFIIB from the transcription complex during transcription initiation. Binds to TFIIB and specifically inhibits the formation of the TBP-TFIIB-promoter complexes.
messages: Present with 7820 molecules/cell in log phase SD medium.

559292:YLL033W
gene id: 559292:YLL033W
uniprot id: Q07843
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the IRC19 family.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.
messages: During sporulation.
messages: Involved in sporulation and maintenance of the mitochondrial DNA. Is probably involved in a pathway contributing to genomic integrity.

559292:YPR006C
gene id: 559292:YPR006C
uniprot id: Q12031
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA. Does not act on isocitrate.
messages: Mitochondrion matrix
messages: Present with 1084 molecules/cell in log phase SD medium.
messages: Repressed by glucose and induced by ethanol and threonine.

559292:YOR281C
gene id: 559292:YOR281C
uniprot id: Q12017
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosducin family.
messages: Cytoplasm
messages: Essential for cell growth (PubMed:10749875). Inhibits early G-protein signaling events following pheromone stimulation (PubMed:10749875). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) CCT2 which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Plays a role in cell cycle progression in G1/S phase (PubMed:17429077).
messages: Impaired growth, cytoskeletal disruptions caused by actin polarization defects, and abberent nuclear segregation caused by misoriented mitotic spindles (PubMed:17429077). Cells are enlarged or do not bud, caused by cell cycle arrest in G1/S phase (PubMed:17429077).
messages: Interacts with the G protein beta-gamma subunit complex (STE4-STE18 complex) (PubMed:10749875). Interacts with CCT2; this interaction leads to inhibition of CCT complex mediated actin folding (PubMed:17429077).
messages: Present with 7700 molecules/cell in log phase SD medium.

559292:YLL039C
gene id: 559292:YLL039C
uniprot id: P0CG63
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family.
messages: Cytoplasm
messages: Nucleus
messages: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: Ubiquitin is encoded by 4 different genes. UBI1 and UBI2 genes code for a single copy of ubiquitin fused to the ribosomal proteins L40. UBI3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein S37. UBI4 is a polyprotein containing 5 exact head to tail repeats of ubiquitin.

559292:YKL106W
gene id: 559292:YKL106W
uniprot id: Q01802
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix
messages: Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity).
messages: Present with 2910 molecules/cell in log phase SD medium.

559292:YER049W
gene id: 559292:YER049W
uniprot id: P40032
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPA1 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Decrease of translation termination efficacy and an increase in mRNAs half-lives and longer mRNA poly(A) tails.
messages: Monomer and homodimer (PubMed:20630870, PubMed:20040577). Interacts with FRK1, eRF1 (SUP1), eRF3 (SUP35) and polyadenylate-binding protein PAB1. Interacts with ETT1 (PubMed:16809762, PubMed:20489023).
messages: Nucleus
messages: Present with 8910 molecules/cell in log phase SD medium.
messages: Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-64' of small ribosomal subunit uS12 (RPS23A and RPS23B), thereby regulating protein translation termination efficiency. Part of a messenger ribonucleoprotein (mRNP) complex at the 3'-UTR of mRNAs. It associates specifically with components of the translation termination complex and is involved in both translation termination and in regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.

559292:YCR017C
gene id: 559292:YCR017C
uniprot id: P25618
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the PGAP2IP family.
messages: In the N-terminal section; belongs to the PGAP2 family.
messages: Involved in the maintenance of cell wall integrity. Required for the replacement of the diacylglycerol moiety by ceramides during GPI-anchor maturation.
messages: The PGAP2-like region interacts with the PGAP2IP-like region.

559292:YGL016W
gene id: 559292:YGL016W
uniprot id: P32767
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the nuclear pore complex (NPC). Interacts with GSP2, NUP1, NUP2, TOA1, TOA2 and WTM1.
messages: Belongs to the importin beta family.
messages: Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR). May play a role in regulation of pleiotropic drug resistance.
messages: Nucleus envelope
messages: Present with 9760 molecules/cell in log phase SD medium.

559292:YKL127W
gene id: 559292:YKL127W
uniprot id: P33401
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Minor phosphoglucomutase isozyme that catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate (PubMed:5784209). Constitutes about 10-20% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755). Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884).
messages: Monomer.
messages: Present with 9820 molecules/cell in log phase SD medium.

559292:YML126C
gene id: 559292:YML126C
uniprot id: P54839
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Drastically increases HMG2 half-life.
messages: Hydroxymethylglutaryl-CoA synthase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:12702274). ERG13 condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA) (PubMed:12702274). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672).
messages: Present with 34800 molecules/cell in log phase SD medium.

559292:YOR212W
gene id: 559292:YOR212W
uniprot id: P18851
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma. The beta-gamma subunit complex (STE4-STE18 complex) interacts with PLP1 and PLP2. Interacts with SYG1.
messages: Implicated in the a- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Present with 2050 molecules/cell in log phase SD medium.

559292:YDR406W
gene id: 559292:YDR406W
uniprot id: Q04182
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane
messages: Transcriptionally regulated by PDR8.

559292:YAL021C
gene id: 559292:YAL021C
uniprot id: P31384
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. CCR4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth and it mediates or is required for the action of the SPT6 and SPT10 genes.
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2780 molecules/cell in log phase SD medium.
messages: Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.
messages: The 169 C-terminal residues are important for deadenylase activity.

559292:YHL036W
gene id: 559292:YHL036W
uniprot id: P38734
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: To yeast high affinity methionine permease (MUP1).
messages: Very low affinity permease for methionine.

559292:YER147C
gene id: 559292:YER147C
uniprot id: P40090
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC4/mau-2 family.
messages: Interacts with SCC2 to form the cohesin loading complex.
messages: Involved in sister chromatid cohesion (PubMed:10882066). Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes (PubMed:10882066, PubMed:26038942). Binds to the nucleosome-free promoter regions of ribosomal protein genes and tRNA genes (PubMed:25173104).
messages: Nucleus
messages: Present with 907 molecules/cell in log phase SD medium.

559292:YGR260W
gene id: 559292:YGR260W
uniprot id: P53322
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Allantoate permease family.
messages: Involved in the uptake of nicotinic acid.
messages: Membrane

559292:YIR002C
gene id: 559292:YIR002C
uniprot id: P40562
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance (PubMed:10880470, PubMed:15126389, PubMed:15634678, PubMed:16121259). Capable of unwinding D-loops (PubMed:19136626). Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair (PubMed:19136626). Prevents crossovers between ectopic sequences by removing substrates for MUS81-MMS4 or RAD1-RAD10 cleavage (PubMed:24119400). Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable) (PubMed:22912599). Binds to flap-structured DNA but not to non-flap nicked DNA, and participates in Okazaki fragment processing by stimulating the endonuclease activities of FEN1 and DNA2 (PubMed:19181670). Involved in recombination donor preference during mating-type switching via interaction with FKH1 (PubMed:27257873).
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
messages: Causes transiant accumulation of ectopic joint molecules (JMs) (PubMed:24119400). Leads to a defect in donor preference during mating-type switching (PubMed:27257873). Does not affect FKH1's overlapping role with FKH2 of regulation of the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle (PubMed:27257873).
messages: Interacts with the MHF histone-fold complex composed of MHF1 and MHF2 to form the FANCM-MHF complex (By similarity). Interacts with FHK1 (PubMed:27257873).
messages: Nucleus
messages: Phosphorylation at both Thr-776 and Thr-785 is required for the interaction with FKH1.

559292:YGR105W
gene id: 559292:YGR105W
uniprot id: P41806
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Functions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29.
messages: Present with 1480 molecules/cell in log phase SD medium.

559292:YDL076C
gene id: 559292:YDL076C
uniprot id: Q07458
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RXT3 family.
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
messages: Nucleus
messages: Present with 3060 molecules/cell in log phase SD medium.

559292:YBR199W
gene id: 559292:YBR199W
uniprot id: P38131
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Membrane
messages: Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
messages: Present with 5240 molecules/cell in log phase SD medium.

559292:YMR177W
gene id: 559292:YMR177W
uniprot id: Q03218
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Mitochondrial metal transporter involved in mitochondrial iron accumulation.
messages: Mitochondrion membrane
messages: Present with 6490 molecules/cell in log phase SD medium.

559292:YBL022C
gene id: 559292:YBL022C
uniprot id: P36775
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner (PubMed:15870080, PubMed:16428434, PubMed:8146662, PubMed:8276800, PubMed:8354406, PubMed:8810243, PubMed:9405361, PubMed:9724747, PubMed:35143841). Endogenous substrates include ABF2, ACO2, ILV1, ILV2, LSC1, LYS4, MGM101 and several oxidized proteins. The 2 nucleic acid-binding proteins ABF2 and MGM101 are protected from degradation by PIM1 when they are bound to DNA (PubMed:16428434, PubMed:20150421, PubMed:28377575).
messages: Belongs to the peptidase S16 family.
messages: Homohexamer (PubMed:35143841) (Probable). Organized in a ring with a central cavity (PubMed:10359790). The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber (PubMed:35143841). Oligomerization is independent of its proteolytic activity and the autocatalytic maturation of its subunits (PubMed:9724747).
messages: Mitochondrion matrix
messages: Present with 14500 molecules/cell in log phase SD medium.

559292:YNL295W
gene id: 559292:YNL295W
uniprot id: P48564
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion
messages: Present with 504 molecules/cell in log phase SD medium.

559292:Q0250
gene id: 559292:Q0250
uniprot id: P00410
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX2 is a catalytic core subunit which transfers the electrons from cytochrome c via its dinuclear copper A center (CU(A)) to the BNC of the COX1 (PubMed:30598554).
messages: Mitochondrion inner membrane
messages: The N-terminal sequence of COX2 is processed by IMP1.

559292:YLR357W
gene id: 559292:YLR357W
uniprot id: Q06488
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RSC1 family.
messages: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in meiotic sporulation through regulating IME2 expression, and is also essential for 2-micron plasmid maintenance and for normal REP1 protein localization.
messages: Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
messages: Heterochromatin spreading downstream of the silent mating-type locus HMR.
messages: Nucleus
messages: Present with 2330 molecules/cell in log phase SD medium.

559292:YDL107W
gene id: 559292:YDL107W
uniprot id: P40990
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with COX18.
messages: Mitochondrion inner membrane
messages: Present with 736 molecules/cell in log phase SD medium.
messages: Required to stabilize mitochondrial cytochrome C oxidase subunit 2 (COX2) and to translocate the C-terminal domain of COX2 through the inner membrane.

559292:YPL002C
gene id: 559292:YPL002C
uniprot id: Q12483
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which consists of 2 copies of VPS25, 1 copy of SNF8, and 1 copy of VPS36. The ESCRT-II complex interacts directly with the VPS20 subunit of the ESCRT-III complex.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
messages: Cytoplasm
messages: Endosome membrane
messages: Present with 1040 molecules/cell in log phase SD medium.

559292:YDL047W
gene id: 559292:YDL047W
uniprot id: P20604
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Functions in the late cell cycle G1 phase for progression into the S phase, possibly associated in two separate complexes with the phosphorylated forms of p155 and p190, two high MW proteins.
messages: Inactivated in a complex with phosphatase methylesterase PPE1 (PP2Ai). Interacts with phosphatase 2A activator RRD1, which can reactivate PP2Ai by dissociating the catalytic subunit from the complex. Forms a ternary complex with RRD1-TAP42.
messages: Involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1. Associates with the SAP proteins in a cell cycle-dependent manner.
messages: Present with 3970 molecules/cell in log phase SD medium.

559292:YBR165W
gene id: 559292:YBR165W
uniprot id: P38290
names: Function
messages: Not known; its elevated expression suppresses the conditional cell cycle defects associated with UBC3/CDC34 mutations.

559292:YMR037C
gene id: 559292:YMR037C
uniprot id: P33748
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with WHI2.
messages: Nucleus
messages: Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes. May be regulated via WHI2-PSR1 complex phosphatase activity.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: The 9aaTAD motif (residues 261 to 269) is a transactivation domain present in a large number of yeast and animal transcription factors.

559292:YLR308W
gene id: 559292:YLR308W
uniprot id: Q06703
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polysaccharide deacetylase family.
messages: Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate (PubMed:9133736, PubMed:11812231). Chitosan is a component of the spore wall (PubMed:9133736).
messages: Induced during sporulation.
messages: Monomer.
messages: N-glycosylated.
messages: Prospore

559292:YJR099W
gene id: 559292:YJR099W
uniprot id: P35127
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C12 family.
messages: Can hydrolyze human UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. It can do so despite of the fact that the C-terminal 'Gly-76' of ubiquitin has been substituted for a tyrosine in UBB(+1).
messages: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or RUB1. Preferentially cleaves ubiquitin from peptides and small adducts.

559292:YAR071W
gene id: 559292:YAR071W
uniprot id: P35842
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the histidine acid phosphatase family.
messages: Glycosylated during secretion across the membrane.
messages: Present with 1460 molecules/cell in log phase SD medium.
messages: S.cerevisiae has 2 types of acid phosphatase: one is constitutive and the other is repressible by inorganic phosphate.

559292:YGR251W
gene id: 559292:YGR251W
uniprot id: P53317
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 90S pre-ribosome. Interacts with RNA helicase DHR2 and RNA helicase-like protein UTP25.
messages: Present with 1460 molecules/cell in log phase SD medium.
messages: Ribosome biogenesis factor required for cleavage of pre-rRNA at A0, A1 and A2 sites. Essential for the incorporation of UTP25 in pre-ribosomes.
messages: nucleolus

559292:YHR139C
gene id: 559292:YHR139C
uniprot id: P13130
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Induced at very late stage of sporulation.
messages: Serves a protective function during the early stages of spore wall formation, and contributes to spore wall maturation.
messages: The program of events of meiosis and spore formation reflects the sequential expression of at least four temporally distinct classes of sporulation-specific genes, SPS100 and SPS101 genes define a distinct class of very late sporulation genes.
messages: To yeast YGP1.

559292:YNL125C
gene id: 559292:YNL125C
uniprot id: P53918
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Endoplasmic reticulum membrane

559292:YHR131C
gene id: 559292:YHR131C
uniprot id: P38835
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YDR374W-A
gene id: 559292:YDR374W-A
uniprot id: Q2V2P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-W/WIP1 family.
messages: Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1.
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:22561346).
messages: Nucleus
messages: kinetochore

559292:YMR087W
gene id: 559292:YMR087W
uniprot id: Q04299
names: Function
names: Subunit
messages: Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. + phosphate.
messages: Homodimer.

559292:YNR070W
gene id: 559292:YNR070W
uniprot id: P53756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

559292:YJL125C
gene id: 559292:YJL125C
uniprot id: P46959
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:10779558, PubMed:9851972). GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency (PubMed:9539420).
messages: Heterotetramer; composed of two copies of TRM6/GCD10 and two copies of TRM61/GCD14.
messages: Nucleus
messages: Present with 7220 molecules/cell in log phase SD medium.

559292:YHR100C
gene id: 559292:YHR100C
uniprot id: P38812
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GEP4 family.
messages: Mitochondrion inner membrane
messages: Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways. Required for the stability of respiratory chain supercomplexes and for growth at elevated temperature, in presence of ethidium bromide or in absence of prohibitins.

559292:YOL019W
gene id: 559292:YOL019W
uniprot id: Q08157
names: Subcellular Location Annotation
messages: Cell membrane
messages: Vacuole membrane

559292:YFR008W
gene id: 559292:YFR008W
uniprot id: P43592
names: Function
names: Miscellaneous
names: Subunit
messages: Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
messages: Participates in the control of the reentry into the cell cycle following pheromone treatment.
messages: Present with 1540 molecules/cell in log phase SD medium.

559292:YDR385W
gene id: 559292:YDR385W
uniprot id: P32324
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Binds to 80S ribosomes (PubMed:12692531, PubMed:14976550, PubMed:15316019). Interacts with the 40S ribosomal subunit protein RPL9A; the interaction is direct (PubMed:14976550). Interacts with the 60S ribosomal subunit proteins RPL12A; the interaction is direct (PubMed:14976550). Interacts with RPS23A; the interaction is direct (PubMed:14976550). Interacts with 18S rRNA; the interaction is direct (PubMed:14976550). Interacts with 25S rRNA; the interaction is direct (PubMed:14976550). Interacts with RPL0 (PubMed:12410829).
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm
messages: Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus abolishing its function.
messages: Inhibited by fusidic acid and sordarin, which prevent the release of eEF2 from the ribosome after the translocation step (PubMed:9452424, PubMed:12692531, PubMed:14976550). While fusidic acid acts on all eukaryotic eEF2, sordarin specifically binds and inhibits only selected fungal eEF2 (PubMed:9452424).
messages: Present with 160782 molecules/cell in log phase SD medium.
messages: There are 2 genes for eEF2 in yeast.

559292:YGR103W
gene id: 559292:YGR103W
uniprot id: P53261
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (PubMed:16287855). Also interacts with NOG1 (PubMed:16888624). May also associate with the origin recognition complex (ORC complex) (PubMed:12110181).
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Essential gene. Reduced assembly of 60S ribosomes and accumulation of halfmer polyribosomes.
messages: Expression is down-regulated prior to the diauxic shift.
messages: Present with 4530 molecules/cell in log phase SD medium.
messages: nucleolus
messages: nucleoplasm

559292:YHR190W
gene id: 559292:YHR190W
uniprot id: P29704
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phytoene/squalene synthase family.
messages: Endoplasmic reticulum membrane
messages: Expression is increased in mutants with phenotypes consistent with known sterol biosynthetic mutations (ERG3, ERG7, ERG24) (PubMed:10209263). The sterol inhibitors zaragozic acid and ketoconazole, which target squalene synthase and the C-14 sterol demethylase respectively, also cause an increase in expression (PubMed:10209263). Heme mutants increase ERG9 expression while anaerobic conditions decrease expression (PubMed:10209263). Additionally, the heme activator protein transcription factors HAP1 and HAP2/3/4, the yeast activator protein transcription factor yAP-1, and the phospholipid transcription factor complex INO2/4 regulate ERG9 expression (PubMed:10209263).
messages: Impairs the production of ergosterol and leads to a 6-fold increase in the synthesis of polyprenols.
messages: Microsome
messages: Present with 10800 molecules/cell in log phase SD medium.
messages: Squalene synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1807826, PubMed:2068081, PubMed:8323279, PubMed:9742963). ERG9 produces squalene from 2 farnesyl pyrophosphate moieties (PubMed:1807826, PubMed:8323279). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of th…

559292:YLR103C
gene id: 559292:YLR103C
uniprot id: Q08032
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles into a complex with MCM5/CDC46. Interacts with MCM10.
messages: Belongs to the CDC45 family.
messages: Nucleus
messages: Present with 1730 molecules/cell in log phase SD medium.
messages: Required for initiation of chromosomal DNA replication. Acts at the origin of replication. Also has a role in minichromosome maintenance.

559292:YML094W
gene id: 559292:YML094W
uniprot id: Q04493
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Present with 2900 molecules/cell in log phase SD medium.

559292:YDR350C
gene id: 559292:YDR350C
uniprot id: P50273
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP22 family.
messages: Mitochondrion inner membrane
messages: Translation factor specific for subunit 6 of the mitochondrial ATPase. Required for assembly of the CF(0) component of the ATPase.

559292:YDL146W
gene id: 559292:YDL146W
uniprot id: Q12342
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB17 family.
messages: Bud
messages: Bud neck
messages: Cytoplasm
messages: May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.
messages: Present with 329 molecules/cell in log phase SD medium.

559292:YGR274C
gene id: 559292:YGR274C
uniprot id: P46677
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF1 family.
messages: Compared to higher eukaryotes TAF1, yeast TAF1 lacks the C-terminal bromodomains and C-terminal kinase activity. The TFIID interacting proteins BDF1 and BDF2 may substitute for these domains.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus
messages: Present with 1500 molecules/cell in log phase SD medium.
messages: The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.

559292:YPL028W
gene id: 559292:YPL028W
uniprot id: P41338
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:7989303, PubMed:5571829). ERG10 catalyzes the formation of acetoacetyl-CoA from acetyl-CoA (PubMed:7989303, PubMed:5571829). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672).
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Homotetramer.
messages: Induced by low intracellular sterol levels (PubMed:8754796). Also highly induced by cold conditions (PubMed:12039763).
messages: Leads to cold and freeze sensitivity.
messages: Present with 60895 molecules/cell in log phase SD medium.
messages: cytosol

559292:YBR139W
gene id: 559292:YBR139W
uniprot id: P38109
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S10 family.
messages: Expression is induced by nitrogen limitation in a GLN3 and GAT1-independent manner.
messages: Leads to vacuolar defects as well as defects in the terminal steps of autophagy, when PCR1 is also deleted (PubMed:29514932). The PCR1/ATG42 double deletion abrogates also the production ofphytochelatin and the degradation of glutathione-S-conjugates (PubMed:17408619, PubMed:19897216).
messages: Present with 1420 molecules/cell in log phase SD medium.
messages: Vacuolar serine-type carboxypeptidase involved in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis (PubMed:29514932). Plays a key role in phytochelatin (PC) synthesis from glutathione (GSH) by cleaving the Gly from GSH and form the PC-peptides of the structure (gamma-Glu-Cys)2-Gly (PubMed:17408619). Also involved in resistance to xenobiotics via the degradation of glutathione-S-conjugates (PubMed:19897216).
messages: Vacuole lumen

559292:YDL052C
gene id: 559292:YDL052C
uniprot id: P33333
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase that catalyzes the sn-2-specific, acyl-CoA-dependent acylation of lysophosphatidic acid (LPA) to phosphatidic acid (PA) in lipid particles (PubMed:9401016). Together with ALE1, plays a central role in PA biosynthesis. PA is the intermediate, from which all glycerophospholipids are synthesized (PubMed:17890783). Can also acylate lysophosphoinositol (LPI) and lysophosphoserine (LPS) (PubMed:17675291). The fatty acyl substrates include 18:1-acyl-CoA, 14:0-acyl-CoA, 12:0-acyl-CoA and 10:0-acyl-CoA (PubMed:20694142).
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Lipid droplet
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

559292:YDR381C-A
gene id: 559292:YDR381C-A
uniprot id: Q3E6R5
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane

559292:YDR316W-B
gene id: 559292:YDR316W-B
uniprot id: P0C2I2
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YDR316W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YNL163C
gene id: 559292:YNL163C
uniprot id: P53893
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.
messages: Cytoplasm
messages: GTPase activity is stimulated in the presence of 60S subunits.
messages: GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SDO1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2.
messages: Present with 7770 molecules/cell in log phase SD medium.

559292:YJL030W
gene id: 559292:YJL030W
uniprot id: P40958
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAD2 family.
messages: Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Thought to be recruited to unattached kinetochores by MAD1. During checkpoint activity, MAD2 is relayed from the MAD1-MAD2 complex to the mitotic checkpoint complex (MCC). MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20.
messages: Component of the mitotic checkpoint complex (MCC) which consists of MAD2, MAD3, BUB3 and CDC20, and of the MAD2-CDC20 subcomplex, both of which appear to be assembled during mitoisis independently of the kinetochore. In mitose-arrested cells, MAD2-CDC20 occurs in a larger amount than MCC. Interacts with CDC20 and BUB3.
messages: Nucleus
messages: Present with 1110 molecules/cell in log phase SD medium.

559292:YDL027C
gene id: 559292:YDL027C
uniprot id: Q07349
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YPR024W
gene id: 559292:YPR024W
uniprot id: P32795
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An increased rate of escape of mtDNA to the nucleus, no growth on nonfermentable carbon sources at 37 degrees Celsius, a cold-sensitive defect in growth on fermentable carbon sources, lethality in rho- (cytoplasmic petite) cells.
messages: Binds 1 zinc ion per subunit.
messages: Catalytic subunit of the mitochondrial inner membrane i-AAA protease supercomplex required for mitochondrial inner membrane protein turnover. The protease is probably ATP-dependent. Important to maintain the integrity of the mitochondrial compartment. Required both for the degradation of unassembled subunit 2 of cytochrome c oxidase (COX2) and for efficient assembly of mitochondrial respiratory chain. Binds unfolded substrates in an ATPase-independent manner; binding of folded COX2, a physiological substrate, requires an active ATPase but when COX2 is destabilized an active ATPase is no longer necessary.
messages: Component of the mitochondrial inner membrane i-AAA protease supercomplex composed of MGR1, MGR3 and YME1. Interacts directly with MGR1.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.
messages: Mitochondrion inner membrane
messages: Present with 20100 molecules/cell in log phase SD medium.

559292:YAL064W-B
gene id: 559292:YAL064W-B
uniprot id: O13512
names: Subcellular Location Annotation
messages: Membrane

559292:YIL088C
gene id: 559292:YIL088C
uniprot id: P40501
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Probable amino acid transporter of unknown specificity.
messages: Vacuole membrane

559292:YHR212W-A
gene id: 559292:YHR212W-A
uniprot id: P0CX90
uniprot id: P0CX91
names: Caution
names: Miscellaneous
names: Similarity
messages: Belongs to the flocculin family.
messages: Could be the product of a pseudogene unlikely to encode a functional protein. The ORF corresponds to a fragmentary flocculin piece with sequence similarity to FLO1. Because of that it is not part of the S.cerevisiae S288c complete/reference proteome set.
messages: Could be the product of a pseudogene. The ORF corresponds to a fragmentary flocculin piece with sequence similarity to FLO1.

559292:YBR030W
gene id: 559292:YBR030W
uniprot id: P38222
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Nucleus
messages: Present with 7880 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-40'.

559292:YMR288W
gene id: 559292:YMR288W
uniprot id: P49955
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with RDS3.
messages: Belongs to the SF3B1 family.
messages: Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly.
messages: Nucleus
messages: Present with 521 molecules/cell in log phase SD medium.

559292:YER006W
gene id: 559292:YER006W
uniprot id: P40010
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family.
messages: GTPase required for 60S ribosomal subunit export to the cytoplasm.
messages: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
messages: Nucleus
messages: Present with 7130 molecules/cell in log phase SD medium.

559292:YHR048W
gene id: 559292:YHR048W
uniprot id: P38776
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: Membrane
messages: Probable drug/proton antiporter.
messages: Up-regulated in cells exhibiting reduced susceptibility to azoles.

559292:YJL011C
gene id: 559292:YJL011C
uniprot id: P47076
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Forms a Pol III subcomplex with RPC25/RPC8. Interacts with BURF1/TDS4.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation.
messages: Nucleus
messages: Present with 2930 molecules/cell in log phase SD medium.

559292:YMR160W
gene id: 559292:YMR160W
uniprot id: Q03823
names: Miscellaneous
messages: Present with 279 molecules/cell in log phase SD medium.

559292:YCL057C-A
gene id: 559292:YCL057C-A
uniprot id: Q96VH5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex. Interacts with OM45 and POR1.
messages: Mitochondrion inner membrane
messages: Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 60-70% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.

559292:YBR025C
gene id: 559292:YBR025C
uniprot id: P38219
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: By hydrogen peroxide and during DNA replication stress.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer (By similarity). Interacts with the 26S proteasome subunit RPT6.
messages: Present with 36803 molecules/cell in log phase SD medium.

559292:YOR202W
gene id: 559292:YOR202W
uniprot id: P06633
names: Cofactor
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Binds 2 manganese ions per subunit.
messages: Induced by histidine starvation in a GCN4-dependent manner.
messages: Present with 2100 molecules/cell in log phase SD medium.

559292:YNL106C
gene id: 559292:YNL106C
uniprot id: P50942
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptojanin family.
messages: Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Interacts with ABP1 and BSP1.
messages: The SAC1 domain is capable of hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
messages: actin patch

559292:YGR244C
gene id: 559292:YGR244C
uniprot id: P53312
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:9874242). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity).

559292:YOR184W
gene id: 559292:YOR184W
uniprot id: P33330
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Homodimer.
messages: Present with 15900 molecules/cell in log phase SD medium.

559292:YGR090W
gene id: 559292:YGR090W
uniprot id: P53254
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NRAP family.
messages: Interacts with snoRNA U3 (PubMed:15590835). Interacts with MPP10 (PubMed:15590835). Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835). Interacts with UBP10 (PubMed:22902402, PubMed:26149687).
messages: Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: Present with 3260 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YBR201W
gene id: 559292:YBR201W
uniprot id: P38307
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the derlin family.
messages: Component of the HRD1 ubiquitin ligase complex which contains the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873066, PubMed:32327568). Within the complex, interacts with USA1 (via C-terminus) (PubMed:20005842, PubMed:32327568). In ERAD-L, HRD3 and YOS9 jointly bind misfolded glycoproteins in the endoplasmic reticulum (ER) lumen (PubMed:32327568). Movement of ERAD-L substrates through the ER membrane is facilitated by HRD1 and DER1 which have lateral gates facing each other and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568). The HRD1 complex interacts with the heterotrimeric CDC48-NPL4-UFD1 ATPase complex which is recruited by UBX2 via its interaction with CDC48 and which moves ubiquitinated substrates to the cytosol for targeting to the proteasome (PubMed:16873066).
messages: Component of the endoplasmic reticulum-associated degradation (ERAD) pathway. Specifically required for the ERAD-L pathway which mediates the degradation of proteins with misfolded lumenal domains within the endoplasmic reticulum (ER). Facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with HRD1 (PubMed:32327568). Both proteins have lateral gates facing each other and distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568).
messages: Endoplasmic reticulum membrane
messages: Impaired degradation of proteins with misfolded lumenal domains such as CPY*, a mutant, misfolded form of carboxypeptidase Y which is a known ERAD-L substrate. Degradation of proteins with misfolded intramembrane domains is not affected.
messages: N-terminally acetylated by acetyltransferase NatB which enhances DER1 stability and is required for ERAD-L function.
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Up-regulated by the unfolded protein response (UPR).

559292:YBL090W
gene id: 559292:YBL090W
uniprot id: P38175
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS21 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YGL117W
gene id: 559292:YGL117W
uniprot id: P53133
names: Miscellaneous
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YPR043W
gene id: 559292:YPR043W
uniprot id: P0CX25
uniprot id: P0CX26
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 44600 molecules/cell in log phase SD medium.
messages: Present with 45500 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL43 in yeast.

559292:YHR002W
gene id: 559292:YHR002W
uniprot id: P38702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Required for the accumulation of coenzyme A in the mitochondrial matrix.

559292:YML039W
gene id: 559292:YML039W
uniprot id: Q03434
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YML040W ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YAL020C
gene id: 559292:YAL020C
uniprot id: P31386
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with KTI11/DPH3; the interaction is direct.
messages: Together with KTI11; associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex (PubMed:18466297, PubMed:25543256). Association with the elongator complex is mediated via interaction with KTI11 (PubMed:18466297, PubMed:25543256). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:25543256). Together with KTI11; also required for diphthamide biosynthesis; diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:25543256). May participate in regulatory interactions between microtubules and the cell cycle (PubMed:8070652).

559292:YML125C
gene id: 559292:YML125C
uniprot id: Q12746
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: By calorie restriction.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Inhibited by diphenylene iodonium (DPI).
messages: NADH-dependent cytochrome b5 reductase that reduces coenzyme Q6 at the plasma membrane and mediates lifespan extension by calorie restriction by shifting fermentative to respiratory metabolism, probably through modulating the NAD(+)/NADH ratio.
messages: Present with 29000 molecules/cell in log phase SD medium.

559292:YGR258C
gene id: 559292:YGR258C
uniprot id: P07276
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus
messages: Present with 846 molecules/cell in log phase SD medium.
messages: Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.

559292:YKL018C-A
gene id: 559292:YKL018C-A
uniprot id: Q3E7A7
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YIR009W
gene id: 559292:YIR009W
uniprot id: P40567
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with RDS3. Interacts with LEA1.
messages: Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA.
messages: Nucleus
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YDR379C-A
gene id: 559292:YDR379C-A
uniprot id: Q3E785
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.
messages: Interacts with SDH2 within an SDH1-SDH2 subcomplex.
messages: Mitochondrion matrix
messages: OXPHOS incompetent because of a profound and specific reduction of complex II activity.
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDH2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. Acts together with SDHAF3 (SDH7).
messages: Present with 861 molecules/cell in log phase SD medium.

559292:YFL044C
gene id: 559292:YFL044C
uniprot id: P43558
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a complex composed of CDC48, NPL4, UFD1, DOA1, SHP1 and deubiquitinase OTU1; within the complex interacts with CDC48 and DOA1/UFD3.
messages: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Participates in the regulation of the ubiquitin conjugation pathway involving CDC48 by hindering multiubiquitination of substrates at the CDC48 chaperone. May be indirectly involved in PIS1 gene expression.
messages: Nucleus
messages: Present with 2770 molecules/cell in log phase SD medium.
messages: The OTU domain mediates the hydrolase activity and the interaction with CDC48.

559292:YLR233C
gene id: 559292:YLR233C
uniprot id: P17214
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EST1 family.
messages: Directly involved in telomere replication. Associates with telomerase and during its interaction with CDC13, telomerase activity is promoted.
messages: Interacts with CDC13 and MPS3.
messages: Nucleus
messages: telomere

559292:YNL249C
gene id: 559292:YNL249C
uniprot id: P53583
names: Miscellaneous
messages: Present with 1050 molecules/cell in log phase SD medium.

559292:YLR197W
gene id: 559292:YLR197W
uniprot id: Q12460
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP5/NOP56 family.
messages: Interacts with NOP1 and NOP58. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Present with 13500 molecules/cell in log phase SD medium.
messages: Required for 60S ribosomal subunit synthesis.
messages: nucleolus

559292:YNR016C
gene id: 559292:YNR016C
uniprot id: Q00955
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 manganese ions per subunit.
messages: By phosphorylation. The catalytic activity is inhibited by soraphen A, a polyketide isolated from the myxobacterium Sorangium cellulosum and a potent inhibitor of fungal growth.
messages: Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Present with 20200 molecules/cell in log phase SD medium.
messages: Repressed in presence of fatty acids. Repressed 3-fold by lipid precursors, inositol and choline, and also controlled by regulatory factors INO2, INO4 and OPI1.

559292:YER044C
gene id: 559292:YER044C
uniprot id: P40030
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25, ERG26 and ERG27. Also interacts with ERG1, ERG3, ERG5, ERG6 and ERG11.
messages: Part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:11160377, PubMed:12119386, PubMed:15522820, PubMed:15995173). ERG28 has a role as a scaffold to help anchor the catalytic components of the C-4 demethylation complex ERG25, ERG26 and ERG27 to the endoplasmic reticulum (PubMed:12119386, PubMed:15522820, PubMed:15995173). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta…
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YDR301W
gene id: 559292:YDR301W
uniprot id: Q06632
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CFT1 family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of at least PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Interacts with the phosphorylated CTD domain of RPB1/RNA polymerase II.
messages: Nucleus
messages: Present with 639 molecules/cell in log phase SD medium.
messages: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.

559292:YAR010C
gene id: 559292:YAR010C
uniprot id: P0CX57
uniprot id: P0CX58
names: Caution
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Transposon Ty1-A (YARCTy1-1) contains a frameshift at position 610, which disrupts the ORF coding for protein TY1B.
messages: Ty1-A is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-PR1 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YOR001W
gene id: 559292:YOR001W
uniprot id: Q12149
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the exosome component 10/RRP6 family.
messages: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex associates with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure. RRP6 specifically is part of the nuclear form of the RNA exosome complex; the association appears to be mediated by Exo-9 and not by DIS3. Interacts with LRP1. Interacts with NPL3, NOP53 and PAP1.
messages: Deletion mutant is impaired in growth at all temperatures and is nonviable at 37 degrees Celsius. It is defective in the 3' processing of the 5.8S rRNA and accumulates a discrete species, 5.8S + 30, that is 3' extended by about 30 nucleotides. Deletion also causes an accumulation of 7S RNA and 5' ETS and increases the level of poly(A)+ mRNA.
messages: Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site.
messages: Present with 2160 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YAR027W
gene id: 559292:YAR027W
uniprot id: P39547
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DUP/COS family.
messages: Cell membrane
messages: Interacts with ULP1.
messages: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.
messages: Nucleus membrane
messages: Present with 1695 molecules/cell in log phase SD medium.

559292:YLR327C
gene id: 559292:YLR327C
uniprot id: Q06177
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STF2 family.
messages: Mitochondrion
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YLL024C
gene id: 559292:YLL024C
uniprot id: P10592
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds human HTN3/histatin-5, a peptide from saliva, and mediates its fungicidal activity. Interacts with NAP1.
messages: Cytoplasm
messages: May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA2 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.
messages: Present with 364000 molecules/cell in log phase SD medium.
messages: cell wall

559292:YFL014W
gene id: 559292:YFL014W
uniprot id: P22943
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: May play a role in a switch from carbohydrate utilizing metabolism to fatty acid utilizing metabolism.
messages: Present with 4490 molecules/cell in log phase SD medium.
messages: Strong, by heat shock, by entry in the stationary growth phase, and by cAMP, probably via the activity of a cAMP-dependent protein kinase. By glucose starvation and by fatty acids.
messages: To S.pombe hsp9 and C.albicans WH11.

559292:YDR186C
gene id: 559292:YDR186C
uniprot id: Q04007
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum. SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs.
messages: Interacts with ENV10/SND2.
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YGR198W
gene id: 559292:YGR198W
uniprot id: P46951
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YPP1 family.
messages: Cell membrane
messages: Cytoplasmic granule
messages: Interacts with ribosomes.
messages: Involved in endocytosis.
messages: Present with 1640 molecules/cell in log phase SD medium.

559292:YAL065C
gene id: 559292:YAL065C
uniprot id: O13511
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flocculin family.
messages: By FLO1.
messages: Membrane

559292:YDR458C
gene id: 559292:YDR458C
uniprot id: Q03281
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SRP1.
messages: Nucleus inner membrane
messages: Present with 1250 molecules/cell in log phase SD medium.

559292:YOR007C
gene id: 559292:YOR007C
uniprot id: Q12118
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGT family.
messages: Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.
messages: Cytoplasm
messages: Interacts with HSC82, HSP104, MDY2, SSA1 and SSA2.
messages: Present with 9424 molecules/cell in log phase SD medium.

559292:YPL053C
gene id: 559292:YPL053C
uniprot id: P54070
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Required for addition of mannosylphosphate in yeast mannan. Recognizes any oligosaccharides with at least one alpha-1,2-linked mannobiose unit.
messages: Membrane
messages: Present with 4380 molecules/cell in log phase SD medium.

559292:YLR029C
gene id: 559292:YLR029C
uniprot id: P05748
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: There are 2 genes for eL15 in yeast.

559292:YJR138W
gene id: 559292:YJR138W
uniprot id: P47170
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IML1 family.
messages: Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.
messages: Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.
messages: Present with 279 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YPR162C
gene id: 559292:YPR162C
uniprot id: P54791
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
messages: Nucleus
messages: Present with 2170 molecules/cell in log phase SD medium.

559292:YNL069C
gene id: 559292:YNL069C
uniprot id: P26785
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: There are 2 genes for uL13 in yeast.

559292:YER149C
gene id: 559292:YER149C
uniprot id: P40091
names: Function
names: Miscellaneous
messages: Localized to sites of polarized growth and is required for efficient mating and bipolar budding.
messages: Present with 7820 molecules/cell in log phase SD medium.

559292:YPR122W
gene id: 559292:YPR122W
uniprot id: P40851
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Binds 1 zinc ion per subunit.
messages: Bud neck
messages: Interacts with BUD5.
messages: Present with 623 molecules/cell in log phase SD medium.
messages: Probable protease. Involved in axial budding.

559292:YDR480W
gene id: 559292:YDR480W
uniprot id: Q03373
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: By pheromone.
messages: DIG2 and DIG1 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein-protein interaction. DIG2 binds to the DNA binding domain (DBD) of STE12 and thus inhibits transcription when overexpressed.
messages: Forms a complex with DIG1, STE12 and either FUS3 or KSS1. The interaction of FUS3 with STE12 depends on the presence of both DIG1 and DIG2. STE12 is lost from FUS3/DIG1/DIG2 complex after pheromone treatment. DIG1 and DIG2 have also been reported to interact with CLN1 and CLN2.
messages: Nucleus
messages: Phosphorylated by FUS3 and KSS1, in a pheromone-stimulated manner.
messages: Present with 1310 molecules/cell in log phase SD medium.

559292:YDR064W
gene id: 559292:YDR064W
uniprot id: P05756
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm

559292:YOL140W
gene id: 559292:YOL140W
uniprot id: P18544
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion matrix
messages: Present with 2300 molecules/cell in log phase SD medium.
messages: The reaction catalyzed by ACOAT is highly reversible. Moreover this enzyme may transaminate ornithine, although this activity should be of little importance at physiological pH.
messages: catalyzes the conversion of N-acetylglutamate-gamma-semialdehyde (NAGSA) to N-acetylornithine in arginine biosynthesis.

559292:YKL221W
gene id: 559292:YKL221W
uniprot id: P36032
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane
messages: Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane.

559292:YJL170C
gene id: 559292:YJL170C
uniprot id: P46993
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Endomembrane system
messages: Induced by alpha-pheromone. Repressed by the ALPHA2-MCM1 repressor.
messages: Required for receptor inhibition of inappropriately expressed a-factor receptor (STE3) in MAT a cells. Inhibits signaling by relocalizing the G protein beta-gamma (STE4-STE18) subunit to intracellular membranes. May also be a mechanism for the down-regulation of the mating pheromone response after the zygotic fusion event, promoting the transition of the new diploid cell to vegetative growth.

559292:YDL133C-A
gene id: 559292:YDL133C-A
uniprot id: P0CX86
uniprot id: P0CX87
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 11900 molecules/cell in log phase SD medium.
messages: Present with 4910 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL41 in yeast.

559292:YLR427W
gene id: 559292:YLR427W
uniprot id: Q06436
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YGR186W
gene id: 559292:YGR186W
uniprot id: P41895
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.
messages: Present with 1920 molecules/cell in log phase SD medium.
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation.
messages: TFIIF is composed of three different subunits: TFG1/RAP74, TFG2/RAP30 and TAF14.

559292:YLR141W
gene id: 559292:YLR141W
uniprot id: Q02983
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the UAF (upstream activation factor) complex which consists of UAF30, RRN5, RRN9, RRN10, and histones H3 and H4.
messages: Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
messages: nucleolus

559292:YLR313C
gene id: 559292:YLR313C
uniprot id: Q06160
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Bud tip
messages: Conjugated with HUB1. HUB1 has not the classical C-terminal Gly residue, so it is still unknown how conjugation may occur.
messages: Polarity-determining protein which forms a conjugate with the ubiquitin-like modifier HUB1. Involved in bud site selection and cellular morphogenesis during conjugation. Required for pseudohyphal growth.
messages: Present with 672 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YML057W
gene id: 559292:YML057W
uniprot id: P14747
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
messages: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.
messages: Present with 7110 molecules/cell in log phase SD medium.
messages: Was originally thought to originate from a rabbit cDNA library and was known as protein phosphatase 2Bw (PP2Bw).

559292:YIL026C
gene id: 559292:YIL026C
uniprot id: P40541
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ECO1.
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the MCD1/SCC1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
messages: Interacts directly with MCD1 in cohesin complex. Cohesin complexes are composed of the SMC1 and SMC3 heterodimer attached via their hinge domain, MCD1 which link them, and IRR1/SCC3, which interacts with MCD1. The cohesin complex also interacts with SCC2, which is required for its association with chromosomes. Interacts with LIN1.
messages: Nucleus
messages: Present with 4090 molecules/cell in log phase SD medium.
messages: centromere

559292:YMR244C-A
gene id: 559292:YMR244C-A
uniprot id: Q3E846
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6B family.
messages: Cytoplasm
messages: Interacts with COX2.
messages: Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Present with 721 molecules/cell in log phase SD medium.
messages: The Cx9C/Cx10C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.

559292:YJR108W
gene id: 559292:YJR108W
uniprot id: P47146
names: Disruption Phenotype
names: Function
messages: Microtubules are shorter than normal.
messages: Required for normal microtubule organization.

559292:YBR104W
gene id: 559292:YBR104W
uniprot id: P38087
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Present with 1050 molecules/cell in log phase SD medium.

559292:YLR187W
gene id: 559292:YLR187W
uniprot id: Q06315
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with phosphatidylinositol 3-phosphate.
messages: May play a role in cell wall integrity.

559292:YPL249C-A
gene id: 559292:YPL249C-A
uniprot id: O14455
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 5370 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL36 in yeast.

559292:YHR129C
gene id: 559292:YHR129C
uniprot id: P38696
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP1 subfamily.
messages: Core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. Required for proper orientation of the mitotic spindle.
messages: Membrane
messages: Present with 1580 molecules/cell in log phase SD medium.
messages: Self-associates to form an actin-like filament of 8-10 monomers. Component of the dynactin complex composed of at least ARP1, JNM1, NIP100 and ARP10. Dynactin comprises a short rod of the ARP1 filament attached to ARP10 at its pointed-end and probably associated with the capping protein at its barbed-end. The rod is implicated in dynein cargo binding. A sidearm formed by NIP100 projects from the ARP1 filament and is implicated in motor binding (By similarity).
messages: cytoskeleton

559292:YOR036W
gene id: 559292:YOR036W
uniprot id: P32854
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Plays a role in the sorting and targeting of vacuolar proteases.
messages: Ubiquitinated.

559292:YER156C
gene id: 559292:YER156C
uniprot id: P40093
names: Miscellaneous
names: Similarity
messages: Belongs to the MYG1 family.
messages: Present with 6080 molecules/cell in log phase SD medium.

559292:YLR132C
gene id: 559292:YLR132C
uniprot id: Q12208
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:28887445). In a second step acts as a cyclic phosphodiesterase that hydrolyzes a U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate to a U6 snRNA 3'-end-terminated with a 3' phosphate (PubMed:28887445, PubMed:22899009). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:28887445, PubMed:23190533, PubMed:22899009). Could be involved in aerobic respiration (PubMed:14690591).
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Lethal.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus
messages: Present with 486 molecules/cell in log phase SD medium.

559292:YLR392C
gene id: 559292:YLR392C
uniprot id: P18634
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ART10 family.
messages: Cytoplasm
messages: Interacts with RSP5.
messages: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
messages: Present with 736 molecules/cell in log phase SD medium.
messages: Ubiquitinated by RSP5.

559292:YDL123W
gene id: 559292:YDL123W
uniprot id: Q07549
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Present with 6780 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YDR020C
gene id: 559292:YDR020C
uniprot id: Q12084
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: Putative uridine kinase identified in a screen for mutants with increased levels of rDNA transcription.

559292:YDR407C
gene id: 559292:YDR407C
uniprot id: Q04183
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRS120 family.
messages: Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS120 and TRS130. Interacts directly with TRS65.
messages: Present with 259 molecules/cell in log phase SD medium.
messages: Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchanger (GEF) for the Golgi YPT1 GTPase. TRS120 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS130.
messages: cis-Golgi network

559292:YHR117W
gene id: 559292:YHR117W
uniprot id: P38825
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom70 family.
messages: Interacts with TOM40, TOM70 and MBF1.
messages: Involved in MBF1-mediated mitochondrial morphogenesis.
messages: Mitochondrion outer membrane
messages: Present with 4110 molecules/cell in log phase SD medium.

559292:YCL044C
gene id: 559292:YCL044C
uniprot id: P25573
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MGR1 family.
messages: Component of the mitochondrial inner membrane i-AAA protease supercomplex composed of MGR1, MGR3 and YME1. With MGR3, forms a subcomplex that binds to YME1 and to substrates to facilitate proteolysis. Interacts directly with YME1.
messages: Component of the mitochondrial inner membrane i-AAA protease supercomplex required for mitochondrial inner membrane protein turnover. Together with MGR3, functions in an adapter complex that targets substrates to the i-AAA protease for degradation. Required for growth of cells lacking the mitochondrial genome.
messages: Mitochondrion inner membrane
messages: Present with 3410 molecules/cell in log phase SD medium.

559292:YEL026W
gene id: 559292:YEL026W
uniprot id: P39990
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Binds to the 5'-stem-loop of U4 snRNA. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.
messages: nucleolus

559292:YPR166C
gene id: 559292:YPR166C
uniprot id: P10663
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion

559292:YGR019W
gene id: 559292:YGR019W
uniprot id: P17649
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer and homotetramer.
messages: Present with 573 molecules/cell in log phase SD medium.
messages: Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2. Cannot transaminate beta-alanine (BAL).
messages: Subject to nitrogen catabolite repression. Expression is low in the presence of the preferred nitrogen sources, and up-regulated by GABA.

559292:YJL200C
gene id: 559292:YJL200C
uniprot id: P39533
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
messages: Constitutively expressed with a small induction when both glutamate and lysine are missing.
messages: Has very little effect on growth on nonfermentable carbon sources.
messages: Mitochondrion
messages: Present with 4670 molecules/cell in log phase SD medium.
messages: The fermenting yeast S.cerevisiae has 2 aconitases, ACO1 essential for the citric acid cycle, and ACO2 specifically and exclusively contributing to lysine biosynthesis. In contrast, in respiring filamentous fungi the ACO2 homologs (acoB) seem enzymatically inactive and the ACO1 homolog (acoA) is solely responsible for these functions.

559292:YOR133W
gene id: 559292:YOR133W
uniprot id: P32324
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Binds to 80S ribosomes (PubMed:12692531, PubMed:14976550, PubMed:15316019). Interacts with the 40S ribosomal subunit protein RPL9A; the interaction is direct (PubMed:14976550). Interacts with the 60S ribosomal subunit proteins RPL12A; the interaction is direct (PubMed:14976550). Interacts with RPS23A; the interaction is direct (PubMed:14976550). Interacts with 18S rRNA; the interaction is direct (PubMed:14976550). Interacts with 25S rRNA; the interaction is direct (PubMed:14976550). Interacts with RPL0 (PubMed:12410829).
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm
messages: Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus abolishing its function.
messages: Inhibited by fusidic acid and sordarin, which prevent the release of eEF2 from the ribosome after the translocation step (PubMed:9452424, PubMed:12692531, PubMed:14976550). While fusidic acid acts on all eukaryotic eEF2, sordarin specifically binds and inhibits only selected fungal eEF2 (PubMed:9452424).
messages: Present with 160782 molecules/cell in log phase SD medium.
messages: There are 2 genes for eEF2 in yeast.

559292:YPL146C
gene id: 559292:YPL146C
uniprot id: Q12080
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP53 family.
messages: Inhibition of cell growth. Defects in processing of the rRNA components of the 60S ribosomal subunit and accumulation of the corresponding polyadenylated pre-rRNAs. Some delay in the maturation of the 35S primary transcript and 32S pre-rRNA. Delay in 20S pre-rRNA formation and a severe delay in mature 25S and 5.8S rRNA formation, with accumulation of the 35S, 32S, 27S, 26S and 7S pre-rRNAs and a 5' extended form of the 25S rRNA. Complete loss of synthesis of the mature 25S rRNA. Appearance at a low level of aberrant 23S species. Shorter 18S and 5.8S rRNA at the 5' end. Imbalance in the 40S:60S ratio and defects in progression beyond the 27S stage of 25S rRNA maturation during 60S biogenesis. Decreased ribosomes and polysomes and presence of halfmers.
messages: Interacts with CBF5, FPR3, FPR4, NOP2, PIH1, RRN3, RRP6 and PAP2. Interacts with pre-60S ribosomal particles.
messages: Late-acting factor in the nuclear maturation of 60S ribosomal subunits, which is required for normal acquisition of export competence. Required for the export of the large subunit. Acts to stimulate the RNase activity of the exosome complex, and may recruit the exosome to 7S pre-rRNA for processing. Associates with numerous RNAs including the 27S and 7S pre-rRNAs and the box H/ACA snoRNA snR37. Also interacts (via N-terminal region) with the mature 25S rRNA and the mature 5.8S rRNA.
messages: Present with 1600 molecules/cell in log phase SD medium.
messages: nucleolus
messages: nucleoplasm

559292:YLR065C
gene id: 559292:YLR065C
uniprot id: Q99382
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Exhibits cold sensitivity and leads to internal accumulation of precursor CPY.
messages: Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum. SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs (PubMed:27905431). Involved in vacuolar processing and morphology (PubMed:21912603).
messages: Interacts with SND1, PHO88/SND3 and the translocon complex subunit SEC61. ENV10/SND2 and PHO88/SND3 form a complex with the translocon in the endoplasmic reticulum membrane.

559292:YGR249W
gene id: 559292:YGR249W
uniprot id: P53050
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

559292:YGR002C
gene id: 559292:YGR002C
uniprot id: P53201
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC4 family.
messages: Component of the SWR1 chromatin-remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1. Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Interacts with YAF9. Interacts with EAF1.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus
messages: Present with 2230 molecules/cell in log phase SD medium.

559292:YDR373W
gene id: 559292:YDR373W
uniprot id: Q06389
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the recoverin family.
messages: Binds 3 calcium ions via the second, third and fourth EF-hand.
messages: Binds PIK1.
messages: Bud membrane
messages: Present with 7160 molecules/cell in log phase SD medium.
messages: Regulator of phosphatidylinositol 4-kinase PIK1.

559292:YJL038C
gene id: 559292:YJL038C
uniprot id: P47055
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSW4/6 family.
messages: Displays elevated rates of loss of heterozygosity (LOH) (PubMed:18562670). A combined deletion of the LOH1/OSW4 and IRC18/OSW6 has reduced dityrosine incorporation in the outer spore wall (PubMed:23966878).
messages: During sporulation. Repressed during vegetative growth by HST1 and RFM1.
messages: Involved in spore wall assembly (PubMed:23966878). May be involved in maintaining genome integrity (PubMed:18562670).
messages: Membrane
messages: N-glycosylated.

559292:YPR203W
gene id: 559292:YPR203W
uniprot id: Q08994
names: Caution
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Could be the product of a pseudogene. Although strongly related to DNA helicases, it lacks the helicase domains, suggesting that it has no helicase activity.

559292:YOL027C
gene id: 559292:YOL027C
uniprot id: Q08179
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MBA1. Binds to mitoribosomes in order to recruit them to the mitochondrial inner membrane.
messages: Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation (PubMed:11907266, PubMed:15138253). With MBA1, plays a role in ribosomal translation and protein insertion into the inner membrane (PubMed:20427570).
messages: Leads to the absence of respiratory complexes III and IV in mitochondrial inner membrane when MBA1 is also missing.
messages: Mitochondrion inner membrane
messages: Present with 7390 molecules/cell in log phase SD medium.
messages: The matrix-exposed C-terminus contains a 14-3-3-like domain which is necessary and sufficient for interaction with mitochondrial ribosomes.

559292:YCR019W
gene id: 559292:YCR019W
uniprot id: P23060
names: Function
names: Similarity
messages: Necessary for the structural stability of L-A double-stranded RNA-containing particles. Necessary for growth at 37 degrees Celsius as well as for maintenance of the killer plasmid.
messages: To S.pombe SpAC4G8.14c.

559292:YPR182W
gene id: 559292:YPR182W
uniprot id: P54999
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Component of the Sm core complex, present in spliceosomal snRNP U1, U2, U4/U6 and U5. The core complex contains SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively), and is probably a heptameric ring structure. SMX3 specifically interacts with SME1. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: Present with 2570 molecules/cell in log phase SD medium.

559292:YMR134W
gene id: 559292:YMR134W
uniprot id: P40207
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Causes lethality under aerobic growth conditions (PubMed:16630279, PubMed:29773647). Affects the methyl sterol oxidase reaction performed by the C4-methylsterol monooxygenase ERG25 and leads to an increase in intermediate sterols and a corresponding decrease in zymosterol and ergosterol production (PubMed:29773647). Impairs Fe-S cluster synthesis via increased degradation of YFH1 (PubMed:29773647). Leads to increased mitochondrial oxidants (PubMed:29773647). Leads to an increased accumulation of iron from the culture media (PubMed:23892078).
messages: Endoplasmic reticulum membrane
messages: Part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:23892078). ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25 (PubMed:23892078). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to he…
messages: Plays a role in maintaining mitochondrial and plasma membrane integrity and consequently impacting the iron homeostasis, respiratory metabolism and antioxidant response (PubMed:9180083, PubMed:16135527, PubMed:16630279, PubMed:23892078, PubMed:29773647).
messages: Present with 2950 molecules/cell in log phase SD medium.

559292:YMR219W
gene id: 559292:YMR219W
uniprot id: Q03661
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SIR4.
messages: Involved in the clustering of telomeres at the nuclear periphery, forming discrete subcompartments that accumulate a complex of histone-binding silencing factors like SIR4. Required for SIR4-mediated anchoring and partitioning of plasmids.
messages: Nucleus

559292:YBR167C
gene id: 559292:YBR167C
uniprot id: P38291
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
messages: Nucleus

559292:YER115C
gene id: 559292:YER115C
uniprot id: Q01684
names: Function
names: Induction
messages: Expressed during sporulation.
messages: Not essential for sporulation.

559292:YER019W
gene id: 559292:YER019W
uniprot id: P40015
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Activated through localization to mitochondria in specific growth phases.
messages: Belongs to the neutral sphingomyelinase family.
messages: Eliminates endogenous IPS-PLC activities.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: Present with 2170 molecules/cell in log phase SD medium.
messages: Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C) (PubMed:11006294). Regulates sphingolipid metabolism in mitochondria, especially the formation of alpha-hydroxylated very long chain phytoceramides. The generated ceramides contribute to the normal function of mitochondria (PubMed:17880915). Also active on sphingomyelin (SM), but this activity is probably not physiologically relevant (PubMed:11006294).

559292:YLR005W
gene id: 559292:YLR005W
uniprot id: Q04673
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTF2H2 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus
messages: Present with 2340 molecules/cell in log phase SD medium.

559292:YGR054W
gene id: 559292:YGR054W
uniprot id: P53235
names: Function
names: PTM
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. Specifically associates with both 40S subunits and 80S ribosomes.
messages: Ubiquitinated, probably leading to its degradation. May explain why it has a short half-life of 17 minutes.

559292:YGR057C
gene id: 559292:YGR057C
uniprot id: P53237
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Present with 656 molecules/cell in log phase SD medium.
messages: Required for the nitrogen-regulated transport of amino acid permeases GAP1 and PUT4 from the Golgi to the cell surface.
messages: Sensitive to high hydrostatic pressure (mechanical stress).

559292:YPL233W
gene id: 559292:YPL233W
uniprot id: Q12143
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. NSL1 facilitates the attachment of two of the DASH complex components, DAD2 and SPC19, to the kinetochore in a microtubule-dependent manner.
messages: Component of the MIND kinetochore complex, which is composed of at least MTW1, NNF1, NSL1 and DSN1. Interacts with DSN1.
messages: Nucleus
messages: Present with 3710 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YDR387C
gene id: 559292:YDR387C
uniprot id: Q04162
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

559292:YKR027W
gene id: 559292:YKR027W
uniprot id: P36122
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHAPS family.
messages: Component of the CHS5/6 complex composed of the 4 CHAPS proteins BCH1, BCH2, BUD7, and CHS6 as well as at least CHS5 and GTP-bound ARF1. The complex interacts with the cargo protein CHS3.
messages: Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.
messages: Present with 2540 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YDR116C
gene id: 559292:YDR116C
uniprot id: Q04599
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 7000 molecules/cell in log phase SD medium.

559292:YLR343W
gene id: 559292:YLR343W
uniprot id: Q06135
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Expressed exclusively during sporulation (at protein level).
messages: N-glycosylated.
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly.

559292:YJL141C
gene id: 559292:YJL141C
uniprot id: P14680
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Cytoplasm
messages: Negative regulator of the cell cycle acting downstream of the cAMP-dependent protein kinase. Part of a glucose-sensing system involved in growth control in response to glucose availability. Phosphorylates POP2.
messages: Nucleus
messages: Phosphorylated; highly.

559292:YLR256W-A
gene id: 559292:YLR256W-A
uniprot id: P0C2I8
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-LR4 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YJL076W
gene id: 559292:YJL076W
uniprot id: P47035
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RENT complex which is composed of at least NET1, CDC14 and SIR2 (PubMed:12056824, PubMed:11511359). Interacts with NSI1 (PubMed:22362748).
messages: Has a role in chromosome maintenance and is involved in mitotic exit. Inhibits the action of CDC14 by sequestering it in the nucleolus. Also binds to RNA polymerase I and stimulates rRNA synthesis. Influences RDNA chromatin by tethering SIR2 to rDNA in the nucleolus.
messages: Phosphorylated by CDC5.
messages: Present with 1590 molecules/cell in log phase SD medium.
messages: To yeast YKR010c.
messages: nucleolus

559292:YDR242W
gene id: 559292:YDR242W
uniprot id: P22580
names: Similarity
messages: Belongs to the amidase family.

559292:YDR103W
gene id: 559292:YDR103W
uniprot id: P32917
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Component of the pheromone signal transduction pathway. It mediates pheromone signals acting between STE20 and STE11. It is absolutely required for pheromone-induced transcription of FUS1. May play a role in cell-cycle arrest in response to pheromone.
messages: Cytoplasm
messages: May be regulated at the phosphorylation level, and by the mating type of the cell and depends on an intact pheromone-response pathway.
messages: Present with 1900 molecules/cell in log phase SD medium.
messages: To yeast FAR1.

559292:YDL165W
gene id: 559292:YDL165W
uniprot id: P06100
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Forms a NOT protein complex that comprises NOT1, NOT2, NOT3, NOT4 and NOT5. Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1 and NOT5. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.
messages: Nucleus
messages: Present with 2120 molecules/cell in log phase SD medium.

559292:YLR418C
gene id: 559292:YLR418C
uniprot id: Q06697
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC73 family.
messages: Component of the PAF1 complex which consists of at least CDC73, CTR9, LEO1, PAF1 and RTF1. Interacts with FACT subunits POB3 and SPT16.
messages: The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.
messages: nucleoplasm

559292:YDR286C
gene id: 559292:YDR286C
uniprot id: Q05530
names: Similarity
messages: Belongs to the glutaredoxin family. YDR286C subfamily.

559292:YJL149W
gene id: 559292:YJL149W
uniprot id: P47005
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts with SKP1. Component of the probable SCF(DAS1) complex containing CDC53, SKP1, RBX1 and DAS1.
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).

559292:YHR118C
gene id: 559292:YHR118C
uniprot id: P38826
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC6 family.
messages: Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with ORC3, ORC5 and TAH11.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: Nucleus
messages: Present with 2970 molecules/cell in log phase SD medium.

559292:YBL008W
gene id: 559292:YBL008W
uniprot id: P32479
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat HIR1 family.
messages: Chromosome
messages: Component of the HIR complex, composed of HIR1, HIR2, HIR3 and HPC2 (PubMed:16264190, PubMed:16303565, PubMed:9001207, PubMed:9504914). This complex may consist of one copy of HIR1 and HIR3 and two copies of HIR2 and HPC2 (PubMed:16264190). The HIR complex interacts with ASF1 (PubMed:11404324, PubMed:11412995). Interacts with SNF2 (PubMed:10445029). Interacts with SNF5 (PubMed:10445029). Interacts with SWI3 (PubMed:10445029). Interacts with RTT106 (PubMed:19683497). May interact with SPT4 (PubMed:9504914). May self-associate (PubMed:9504914).
messages: Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
messages: Decreases nucleosomal density (PubMed:19683497). Increases HTA1 RNA level; simultaneous disruption RTT109 alleviates the effect (PubMed:19683497). Abolishes localization of RTT106 to the HTA1-HTB1 promoter (PubMed:19683497).
messages: Nucleus
messages: Present with 846 molecules/cell in log phase SD medium.
messages: centromere

559292:YBR020W
gene id: 559292:YBR020W
uniprot id: P04385
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

559292:YAL036C
gene id: 559292:YAL036C
uniprot id: P39729
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with translating polyribosomes. Interacts with GIR2, TMA46, YAP1 and YGR250C.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Involved in ribosomal function.
messages: Present with 11700 molecules/cell in log phase SD medium.

559292:YJR003C
gene id: 559292:YJR003C
uniprot id: P47084
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion
messages: Present with 3280 molecules/cell in log phase SD medium.

559292:YMR070W
gene id: 559292:YMR070W
uniprot id: P54785
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Induced under aerobic conditions and repressed under anaerobic conditions.
messages: Nucleus
messages: Present with 1690 molecules/cell in log phase SD medium.
messages: The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
messages: Transcription factor that affects the expression of a large set of genes. Recognizes and binds to the consensus sequence 5'-[CAT]AGG[TC]A-3' in the promoter region. Plays a major role in the repression of a specific subset of hypoxic genes (e.g. ANB1, DAN1 and HEM13) under aerobic conditions. Acts synergistically with the transcription factor ROX1 to recruit the general repression complex SSN6-TUP1 to the promoter of hypoxic genes. Represses transcription of ergosterol biosynthetic genes. Negatively regulates pheromone-induced gene expression. Can act as a transcriptional activator (e.g. of genes like CYC1, SUC2 and the Ty long terminal repeat delta promoter).
messages: [MOT3+] is the prion form of MOT3. [MOT3+] is the result of a conformational change of the cellular MOT3 protein that becomes self-propagating and infectious. This conformational change generates a form of MOT3 that assembles into amyloid fibrils. [MOT3+]-aggregates sequester soluble MOT3, resulting in a loss-of-function phenotype for MOT3. [MOT3+] can be cured by GdnHCl and by inactivation of the molecular chaperone HSP104, which is required for [MOT3+] propagation. It is speculated that prion properties of transcription factors may generate an optimized phenotypic heterogeneity that buffers yeast populations against diverse environmental insults.

559292:YDL189W
gene id: 559292:YDL189W
uniprot id: Q05672
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 892 molecules/cell in log phase SD medium.

559292:YDR460W
gene id: 559292:YDR460W
uniprot id: Q03290
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.
messages: Component of the transcription factor IIH (TFIIH) holo but not the TFIIH core complex. Component of a complex consisting of KIN28, CCL1 and TFB3; the KIN28-CCL1 dimer is known as the TFIIK complex.
messages: Nucleus
messages: Present with 3050 molecules/cell in log phase SD medium.

559292:YBR234C
gene id: 559292:YBR234C
uniprot id: P38328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ARPC1 family.
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: actin patch

559292:YNL258C
gene id: 559292:YNL258C
uniprot id: P53847
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a peripheral membrane protein complex consisting of DSL1, SEC39/DSL3 and TIP20. Bound to a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6 through direct interaction of TIP20 with SEC20. Binds the coatomer complex through direct interaction with RET2/COPD and RET1/COPA. Binds TIP20 and SEC39/DSL3.
messages: Endoplasmic reticulum membrane
messages: Present with 8970 molecules/cell in log phase SD medium.
messages: Required for protein transport between the Golgi and the endoplasmic reticulum. May tether coatomer-coated retrograde transport vesicles to the ER membrane through interaction with coatomer as well as the SNARE complex. May contribute to the stabilization of the SNARE complex.

559292:YDR281C
gene id: 559292:YDR281C
uniprot id: Q05637
names: Induction
names: Subcellular Location Annotation
messages: Regulated by phosphate levels.
messages: Vacuole membrane

559292:YNL061W
gene id: 559292:YNL061W
uniprot id: P40991
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Interacts with NOP53. Interacts with TRM112.
messages: Present with 18700 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing.
messages: nucleolus

559292:YDL105W
gene id: 559292:YDL105W
uniprot id: P43124
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE4 family.
messages: Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6. Interacts with NSE3.
messages: Nucleus

559292:YOL087C
gene id: 559292:YOL087C
uniprot id: Q99247
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts (via its WD repeats) with ubiquitin.
messages: Present with 589 molecules/cell in log phase SD medium.
messages: The N-terminal WD repeats are involved in ubiquitin-binding.
messages: Ubiquitin-binding protein involved in the resistance to phenanthroline, sanguinarine, nordihydroguaiaretic acid (NDGA), isopropyl (N-3-chloro-phenyl)-carbamate (IPCPC) and guanosine 5'-O-(2-thiodiphosphate).

559292:YLR328W
gene id: 559292:YLR328W
uniprot id: Q06178
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic NMN adenylyltransferase family.
messages: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis. Predominantly acts in the salvage pathways via NMN.
messages: Cytoplasm
messages: Divalent metal cation.
messages: Expression is high in early log-phase and significantly drops as cells enter late log phase.
messages: Homotetramer.
messages: Nucleus
messages: Present with 5130 molecules/cell in log phase SD medium.

559292:YML026C
gene id: 559292:YML026C
uniprot id: P0CX55
uniprot id: P0CX56
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 112000 molecules/cell in log phase SD medium.
messages: Present with 48100 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS13 in yeast.

559292:YFR031C
gene id: 559292:YFR031C
uniprot id: P38989
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
messages: Chromosome
messages: Cytoplasm
messages: Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.
messages: Nucleus
messages: Present with 3290 molecules/cell in log phase SD medium.
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.

559292:YPL229W
gene id: 559292:YPL229W
uniprot id: Q99395
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YIL003W
gene id: 559292:YIL003W
uniprot id: P40558
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:12970194, PubMed:15660135, PubMed:17401378). Required for maturation of extramitochondrial Fe-S proteins (PubMed:12970194, PubMed:15660135, PubMed:17401378, PubMed:22362766, PubMed:31040179). The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:17401378, PubMed:22362766). Nucleotide binding/hydrolysis seems to be critcal for loading of Fe-S clusters onto CFD1 and NBP35 (PubMed:22362766). Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export (PubMed:15660135).
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.
messages: Inviable (PubMed:12970194). Decreases cytosolic iron-sulfur (Fe-S) protein assembly (PubMed:31040179).

559292:Q0115
gene id: 559292:Q0115
uniprot id: Q9ZZW7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Encoded from partially processed COB mRNA that terminates with the in-frame coding sequence of the third intron.
messages: Forms a ribonucleoprotein complex composed of maturase bI3 and 2 dimers of MRS1 that assemble around the bI3 RNA.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: In the N-terminal section; belongs to the cytochrome b family.
messages: Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (COB) gene, containing its own coding sequence. In vivo splicing requires the formation of a ribonucleoprotein complex together with the imported mitochondrial RNA-splicing protein MRS1. The complex seems to stimulate the intrinsic ribozyme activity of intron bI3 through binding to and stabilizing specific secondary and tertiary structure elements in the RNA.
messages: Mitochondrion inner membrane

559292:YHR137W
gene id: 559292:YHR137W
uniprot id: P38840
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: By aromatic amino acids in the growth medium. Expression also induced in ARO8 mutants grown on minimal ammonia medium.
messages: Cytoplasm
messages: General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Mainly involved in tryptophan degradation. Active with phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate and pyruvate as amino acceptors. Does not accept glutamate or 2-oxoglutarate as substrates. Also active with methionine, leucine, glutamine and kynurenine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) with pyruvate as amino acceptor.
messages: Present with 7700 molecules/cell in log phase SD medium.

559292:YIL039W
gene id: 559292:YIL039W
uniprot id: P40533
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Acts together with EMP24 and ERV25 in cargo exit from the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: N-glycosylated.
messages: Present with 1070 molecules/cell in log phase SD medium.

559292:YGL090W
gene id: 559292:YGL090W
uniprot id: P53150
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Cytoplasm
messages: Interacts with the BRCT domain of DNL4 and with NEJ1. The DNL4-LIF1 complex interacts with POL4.
messages: Nucleus
messages: Present with 876 molecules/cell in log phase SD medium.
messages: Stabilizes DNL4. Involved in non-homologous repair of DNA double-strand breaks.

559292:YDR369C
gene id: 559292:YDR369C
uniprot id: P33301
names: Function
names: Miscellaneous
messages: During meiosis is involved in homologous recombination and during vegetative growth it is necessary for DNA repair. It probably regulates the 5'-3' exonuclease degradation of double strand breaks either at the initiation stage or a later stage.
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YOR253W
gene id: 559292:YOR253W
uniprot id: Q08689
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Component of the N-terminal acetyltransferase A (NatA) complex, which is composed of ARD1, NAT1 and NAT5.
messages: Cytoplasm
messages: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:25886145). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides (PubMed:25886145). Non-essential component of the NatA N-terminal acetyltransferase (PubMed:14517307).
messages: Present with 2370 molecules/cell in log phase SD medium.

559292:YDR047W
gene id: 559292:YDR047W
uniprot id: P32347
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 9220 molecules/cell in log phase SD medium.

559292:YGR067C
gene id: 559292:YGR067C
uniprot id: P53243
names: Subcellular Location Annotation
messages: Nucleus

559292:YMR262W
gene id: 559292:YMR262W
uniprot id: P38430
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Putative deoxyribonuclease.

559292:YDL088C
gene id: 559292:YDL088C
uniprot id: Q05166
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. ASM4 may form a subcomplex with NUP53, NDC1, and NUP170.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). May have a mitosis control function (By similarity).
messages: Nucleus membrane
messages: Phosphorylated by CDC28.
messages: Present with 2740 molecules/cell in log phase SD medium.
messages: The RRM Nup35-type domain might be involved in the control of mitosis.
messages: nuclear pore complex

559292:YPR179C
gene id: 559292:YPR179C
uniprot id: Q06623
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HDA2/3 family. HDA3 subfamily.
messages: Heterodimer with HDA2. Component of the HDA1 histone deacetylase complex composed of at least one HDA1 homodimer and one HDA2/HDA3 heterodimer. Interacts with HDA1 and HDA3.
messages: Nucleus
messages: Present with 1100 molecules/cell in log phase SD medium.
messages: Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

559292:YBR133C
gene id: 559292:YBR133C
uniprot id: P38274
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Bud neck
messages: Interacts with HSL1 and SWE1. Interacts with the amino-terminal regulatory domain of STE20.
messages: Phosphorylated in a cell cycle-dependent manner.
messages: Present with 1180 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that can catalyze both the mono- and symmetric (type II) dimethylation of the guanidino nitrogens of arginine residues in target proteins (PubMed:18515076). Involved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation (PubMed:10490630, PubMed:10490648). Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20 (PubMed:10411908).

559292:YNL187W
gene id: 559292:YNL187W
uniprot id: P53873
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with snRNPs.
messages: Belongs to the SWT21 family.
messages: Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction.
messages: Nucleus

559292:YBR076W
gene id: 559292:YBR076W
uniprot id: P38246
names: Function
messages: May be involved in cell wall organization and biogenesis.

559292:YML052W
gene id: 559292:YML052W
uniprot id: P54003
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUR7 family.
messages: Cell membrane
messages: Involved in sporulation and affects the sphingolipid composition of the plasma membrane. Probably involved in endocytosis.
messages: Present with 17000 molecules/cell in log phase SD medium.

559292:YDR316W
gene id: 559292:YDR316W
uniprot id: Q06668
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METL family.
messages: Mitochondrial methyltransferase which suppresses respiratory defects caused by OXA1 mutations when overexpressed.
messages: Mitochondrion inner membrane
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YGL185C
gene id: 559292:YGL185C
uniprot id: P53100
names: Miscellaneous
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Present with 1430 molecules/cell in log phase SD medium.

559292:YGL148W
gene id: 559292:YGL148W
uniprot id: P28777
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: By amino acid starvation.
messages: Homotetramer.
messages: Present with 2310 molecules/cell in log phase SD medium.

559292:YJL118W
gene id: 559292:YJL118W
uniprot id: P47022
names: Subcellular Location Annotation
messages: Membrane

559292:YLR362W
gene id: 559292:YLR362W
uniprot id: P23561
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer (Probable). Interacts (via SAM domain) with STE50 (via SAM domain). Interacts with PBS2 and SHO1.
messages: Present with 736 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KSS1 kinases.

559292:YLR335W
gene id: 559292:YLR335W
uniprot id: P32499
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. Binds to the nuclear basket of the NPC through NUP60 in a (GSP1, GSP2) GTPase-GTP-dependent manner. Interacts through its FG repeats with nuclear transport factors. Interacts with KAP122.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: FXFG repeats are especially abundant in NUPs on the nucleoplasmic side (in a highly charged environment and enriched in Ser and Thr).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP2 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP1 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP2 binds through its N-terminus to the SRP1 nuclear localization signal (NLS) binding site, thus accelerating the release of the NLS-cargo. SRP1 in turn is released from NUP2 by binding of the GSP1-GTP associated export factor CSE1. NUP2 may also have a chromatin boundary/insulator activity through indirect interaction with genomic DNA via CSE1 and blocking of heterochromatin spreading.
messages: Nucleus membrane
messages: Present with 2960 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YHL017W
gene id: 559292:YHL017W
uniprot id: P38745
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Present with 14600 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YJL178C
gene id: 559292:YJL178C
uniprot id: P46989
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG27 family.
messages: Cytoplasmic vesicle membrane
messages: Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9.
messages: Forms a complex with ATG9 and ATG23.
messages: Golgi apparatus membrane
messages: Mitochondrion membrane
messages: Preautophagosomal structure membrane
messages: Present with 8970 molecules/cell in log phase SD medium.

559292:YEL011W
gene id: 559292:YEL011W
uniprot id: P32775
names: Developmental Stage
names: Miscellaneous
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Expressed during the transition between the late exponential and stationary growth phases, coincident with maximal glycogen accumulation.
messages: Present with 1230 molecules/cell in log phase SD medium.

559292:YJL005W
gene id: 559292:YJL005W
uniprot id: P08678
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
messages: The presence of GTP-bound RAS2 protein is required in order to elicit a magnesium-dependent adenylyl cyclase activity.

559292:YCR036W
gene id: 559292:YCR036W
uniprot id: P25332
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 1780 molecules/cell in log phase SD medium.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

559292:YIL011W
gene id: 559292:YIL011W
uniprot id: P40552
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall. Required for anaerobic growth.
messages: Extensively O-glycosylated.
messages: Induced during anaerobic growth.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

559292:YBR196C
gene id: 559292:YBR196C
uniprot id: P12709
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Homodimer.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.
messages: Present with 91600 molecules/cell in log phase SD medium.
messages: Strongly inhibited by the polyol (sugar alcohol) phosphate D-glucitol 6-phosphate (D-sorbitol 6-phosphate) (PubMed:30240188). Also inhibited by the polyol (sugar alcohol) phosphate D-ribitol 5-phosphate (PubMed:30240188).
messages: cytosol

559292:YPR005C
gene id: 559292:YPR005C
uniprot id: Q01766
names: Function
names: Induction
names: Subcellular Location Annotation
messages: By salt stress.
messages: Cytoplasm
messages: Involved in salt tolerance.

559292:YBR233W
gene id: 559292:YBR233W
uniprot id: P38151
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PAB1.
messages: Nucleus
messages: Present with 1590 molecules/cell in log phase SD medium.

559292:YMR256C
gene id: 559292:YMR256C
uniprot id: P10174
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIa family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: Present with 639 molecules/cell in log phase SD medium.

559292:YJR137C
gene id: 559292:YJR137C
uniprot id: P47169
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.
messages: Cytoplasm
messages: Present with 2900 molecules/cell in log phase SD medium.

559292:YHR030C
gene id: 559292:YHR030C
uniprot id: Q00772
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Activated by tyrosine and threonine phosphorylation by MKK1 and MKK2.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-190 and Tyr-192, which activates the enzyme.
messages: Interacts with RLM1.
messages: Present with 3230 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the SLT2/MPK1 kinase which itself then phosphorylates and activates the transcription factor RLM1. Directly phosphorylates BCY1 upon TOR complex 1 (TORC1) inhibition.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

559292:YOL018C
gene id: 559292:YOL018C
uniprot id: Q08144
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Endosome membrane
messages: Interacts with VPS45.
messages: t-SNARE that functions in transport from the endosome to the late Golgi and on the endocytic pathway.
messages: trans-Golgi network membrane

559292:YLL012W
gene id: 559292:YLL012W
uniprot id: Q07804
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Lipid droplet
messages: Mediates the hydrolysis of steryl esters, thereby playing a central role in lipid metabolism. Under heme-deficient conditions, it constitutes the major steryl ester hydrolase, suggesting that it plays a central role in mobilization of steryl esters under anaerobic conditions.
messages: Membrane
messages: Not N-glycosylated.
messages: Present with 7770 molecules/cell in log phase SD medium.
messages: Under heme-deficiency conditions. Heme-deficient induction requires ROX3.

559292:YGR196C
gene id: 559292:YGR196C
uniprot id: P46949
names: Function
names: Similarity
messages: Belongs to the FYV8 family.
messages: Required for survival upon exposure to K1 killer toxin. Involved in the resistance to unfolded protein response (UPR)-inducing agents.

559292:YBR152W
gene id: 559292:YBR152W
uniprot id: P38282
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPP381 family.
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Interacts with PRP38.
messages: Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA.
messages: Nucleus
messages: Present with 2510 molecules/cell in log phase SD medium.

559292:YOR230W
gene id: 559292:YOR230W
uniprot id: Q12363
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with KAP122.
messages: Nucleus
messages: Present with 7750 molecules/cell in log phase SD medium.
messages: Transcriptional modulator with roles in meiotic regulation and silencing. Acts either as an adapter to facilitate nuclear import by KAP122 of the RNR2-RNR4 herodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR); or as an anchor to retain RNR2-RNR4 in the nucleus.

559292:YML058W
gene id: 559292:YML058W
uniprot id: Q04964
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer; disulfide-linked. Interacts with RNR1.
messages: Levels decrease during S phase.
messages: Nucleus
messages: Phosphorylated by DUN1, a downstream effector of the Mec1/Rad53 checkpoint pathway, in response to DNA damage. This promotes ubiquitination of SML1 and targets it for degradation by the 26S proteasome.
messages: Present with 18800 molecules/cell in log phase SD medium.
messages: Strong inhibitor of ribonucleotide reductase (RNR1) and is involved in regulating dNTP production.

559292:YDR404C
gene id: 559292:YDR404C
uniprot id: P34087
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex. The RPB4-RPB7 subcomplex probably associates with TFG1. Interacts with NRD1 and PAT1.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II.
messages: Nucleus
messages: P-body
messages: Present with 6420 molecules/cell in log phase SD medium.

559292:YJL127C-B
gene id: 559292:YJL127C-B
uniprot id: Q3E828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMR1 family.
messages: Mediates the formation of endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) foci, thereby contributing to the formation of ER-mitochondrial contact sites.
messages: Mitochondrion outer membrane

559292:YML077W
gene id: 559292:YML077W
uniprot id: Q03630
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET5 subfamily.
messages: Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.
messages: Preautophagosomal structure
messages: cis-Golgi network

559292:YLR412W
gene id: 559292:YLR412W
uniprot id: Q06688
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRR1 family.
messages: Involved in microtubule stability and kinetochore function. May be involved in protein N-terminus acetylation and/or proteasome biogenesis.
messages: Present with 6490 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YOR306C
gene id: 559292:YOR306C
uniprot id: Q08777
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Riboflavin transporter involved in riboflavin (vitamin B2) uptake. Does not act in the transport of monocarboxylic acids across the plasma membrane.

559292:YFL047W
gene id: 559292:YFL047W
uniprot id: P43556
names: Function
names: Miscellaneous
names: Subunit
messages: Acts in signal transduction. Activates CDC42 and RHO5.
messages: Interacts with CDC42 and RHO5.
messages: Present with 1750 molecules/cell in log phase SD medium.

559292:YOR369C
gene id: 559292:YOR369C
uniprot id: P48589
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS12 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm

559292:YPL097W
gene id: 559292:YPL097W
uniprot id: P48527
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Homodimer.
messages: Mitochondrion matrix
messages: Present with 996 molecules/cell in log phase SD medium.

559292:YLL006W
gene id: 559292:YLL006W
uniprot id: P41800
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMM1 family.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria (PubMed:19556461). Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:8089172, PubMed:9628893, PubMed:27469264). The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex (PubMed:17410204). Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (PubMed:11266455, PubMed:12454062, PubMed:14981098).
messages: Endoplasmic reticulum membrane
messages: Glycosylated.
messages: Homodimer (By similarity). Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34 (PubMed:13679517, PubMed:17410204, PubMed:19556461). A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking (By similarity).
messages: Loss of mitochondrial integrity (PubMed:26370498). Abolishes growth on non-fermentable carbon source (glycerol with ethanol) (PubMed:26370498, PubMed:27280386). Slow growth on fermentable carbon source (glucose) (PubMed:26370498, PubMed:27280386). Synthetic lethal with VPS13 (PubMed:26370498, PubMed:27280386).
messages: Normal levels of MMM1 require MDM34.
messages: Present with 2490 molecules/cell in log phase SD medium.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
messages: Was originally (PubMed:12972421 and PubMed:8089172) proposed to be inserted into either the outer or inner mitochondrial membrane, yet more recent data indicates that it is instead inserted into the ER.

559292:YLR227W-B
gene id: 559292:YLR227W-B
uniprot id: P0C2I6
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YLR227W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YGL181W
gene id: 559292:YGL181W
uniprot id: P40956
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Appears to modulate the timing of budding to obtain an appropriate cell size independent of the DNA replication cycle. Transcription factor involved in both heat resistance and flocculation.
messages: Nucleus
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YLL021W
gene id: 559292:YLL021W
uniprot id: P23201
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell tip
messages: Interacts with SHS1.
messages: Involved in pheromone-induced morphogenesis and efficient mating, perhaps as a cytoskeletal protein.
messages: Present with 274 molecules/cell in log phase SD medium.

559292:YDR107C
gene id: 559292:YDR107C
uniprot id: Q04562
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Vacuole membrane
messages: With EMP70 and TMN3, plays a critical role in the late stages of a nutrient-controlled pathway notably regulating FLO11 gene expression. Acts downstream of RAS2 and TOR. Essential for cell adhesion and filamentous growth. May play a role as effector of cellular copper homeostasis.

559292:YOR130C
gene id: 559292:YOR130C
uniprot id: Q12375
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Present with 432 molecules/cell in log phase SD medium.
messages: Required for arginine biosynthesis. Transports ornithine synthesized from glutamate in the mitochondrial matrix to the cytosol, where it is converted to arginine.

559292:YJR083C
gene id: 559292:YJR083C
uniprot id: P47129
names: Function
names: Miscellaneous
messages: May be involved in actin cytoskeleton organization and biogenesis.
messages: Present with 1140 molecules/cell in log phase SD medium.

559292:YOR343W-B
gene id: 559292:YOR343W-B
uniprot id: Q12501
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YOR343W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YBR048W
gene id: 559292:YBR048W
uniprot id: P0CX47
uniprot id: P0CX48
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS17 in yeast.

559292:YOR367W
gene id: 559292:YOR367W
uniprot id: Q08873
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds to actin. Interacts with ABP1.
messages: Has actin-binding and actin-bundling activity. Stabilizes actin filaments against disassembly.
messages: Present with 1578 molecules/cell in log phase SD medium.
messages: actin patch

559292:YML020W
gene id: 559292:YML020W
uniprot id: Q03722
names: Miscellaneous
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YPL116W
gene id: 559292:YPL116W
uniprot id: Q02959
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Homodimer.
messages: Nucleus
messages: Present with 4420 molecules/cell in log phase SD medium.
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).

559292:YPL103C
gene id: 559292:YPL103C
uniprot id: Q02883
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAPE-PLD family.
messages: Binds 1 or 2 zinc ions per subunit.
messages: Expressed periodically during the glycolytic and respiratory oscillations cycles.
messages: Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs).
messages: Mitochondrion membrane
messages: Present with 178 molecules/cell in log phase SD medium.

559292:YNL098C
gene id: 559292:YNL098C
uniprot id: P01120
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by guanine nucleotide-exchange factor (GEF) CDC25 and inactivated by GTPase-activating proteins (GAPs) IRA1 and IRA2.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Farnesylated by RAM1-RAM2, which is required for targeting RAS2 to the cytoplasmic site of the endoplasmic reticulum, where proteolytic processing of the C-terminus by RCE1 and methylation of the resulting carboxyl group by STE14 occurs.
messages: Palmitoylated by the ERF2-SHR5 complex, which is required for proper plasma membrane localization of RAS2.
messages: Present with 19800 molecules/cell in log phase SD medium.
messages: RAS2 is necessary for a normal response to nutrient limitations, in general, disruption of the RAS2 locus results in an overall premature starvation response.
messages: The S.cerevisiae Ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-AMP.

559292:YKR096W
gene id: 559292:YKR096W
uniprot id: P36168
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: May be involved in the regulation of gene expression responses of environment-sensing pathways.
messages: Nucleus
messages: Peroxisome
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Transiently interacts with PEX14.

559292:YLR375W
gene id: 559292:YLR375W
uniprot id: Q05937
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 1240 molecules/cell in log phase SD medium.

559292:YOL052C-A
gene id: 559292:YOL052C-A
uniprot id: P89113
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: By multistress. Expression is controlled by the MSN2 and MSN4 transcriptional regulators.
messages: May play an important role in the response of cells to diverse environmental stresses.
messages: Present with 784 molecules/cell in log phase SD medium.
messages: To yeast HOR7.

559292:YGL186C
gene id: 559292:YGL186C
uniprot id: P53099
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane
messages: Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine.

559292:YNR055C
gene id: 559292:YNR055C
uniprot id: P53389
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Seems to be involved in the uptake of several cations and of histidinol.

559292:YGL008C
gene id: 559292:YGL008C
uniprot id: P05030
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: Interacts with its cargot receptor EXP1 for its transport within the cell and maturation.
messages: Phosphorylated on multiple Ser and Thr residues.
messages: Present with 1260000 molecules/cell in log phase SD medium.
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
messages: The prion state [GAR+] is provoked by the interaction of the two proteins STD1 and PMA1. It involves a complex between a small fraction of the cellular complement of PMA1, and STD1, a much lower-abundance protein, and it is transmissible by non-Mendelian, cytoplasmic inheritance. [GAR+] makes cells resistant to the glucose-associated repression of alternative carbon sources. In contrast to other prion forms, [GAR+] cannot be cured by GdnHCl or by inactivation of the molecular chaperone HSP104.
messages: There are two plasma membrane ATPases in yeast. This is the major isoform.

559292:YIL047C
gene id: 559292:YIL047C
uniprot id: P40528
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Cell membrane
messages: May function in G-protein coupled signal transduction.
messages: Present with 1160 molecules/cell in log phase SD medium.

559292:YFL013C
gene id: 559292:YFL013C
uniprot id: P43579
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.
messages: Nucleus
messages: Present with 1400 molecules/cell in log phase SD medium.
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex.

559292:YPL207W
gene id: 559292:YPL207W
uniprot id: Q08960
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYW1 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).
messages: Endoplasmic reticulum
messages: Present with 5410 molecules/cell in log phase SD medium.

559292:YJL218W
gene id: 559292:YJL218W
uniprot id: P40892
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Homodimer.

559292:YJL124C
gene id: 559292:YJL124C
uniprot id: P47017
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape. The LSm subunits are arranged in the order LSM1, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. Except for LSM1, where a C-terminal helix crosses the ring structure to form additional interactions with LSM3 and LSM6, each subunit interacts only with its two neighboring subunits. The LSM1-LSM7 complex interacts with PAT1; within the complex PAT1 has direct interactions with LSM2 and LSM3.
messages: Cytoplasm
messages: Nucleus
messages: P-body
messages: Present with 3490 molecules/cell in log phase SD medium.

559292:YMR085W
gene id: 559292:YMR085W
uniprot id: P0CF18
names: Caution
messages: Could be the product of a pseudogene. This is the C-terminal part of a putative glutamine--fructose-6-phosphate aminotransferase. Strain S288c has a frameshift in position 258, which disrupts the gene coding for this protein and produces two ORFs YMR084W and YMR085W. A contiguous sequence for this protein can be found in strain YJM789 (AC A6ZME2).

559292:YOR138C
gene id: 559292:YOR138C
uniprot id: Q12242
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a ternary complex with RSP5 and UBP2.
messages: Modulates the activity of the RSP5 HECT ubiquitin-protein ligase through its mediation of the interaction between RSP5 and the deubiquitinase UBP2. Involved in regulation of cell wall homeostasis.
messages: Nucleus
messages: Present with 5930 molecules/cell in log phase SD medium.

559292:YGL032C
gene id: 559292:YGL032C
uniprot id: P32781
names: Function
names: Miscellaneous
names: Subunit
messages: Heterodimer; disulfide-linked (Probable). Interacts with SAG1.
messages: Present with 1160 molecules/cell in log phase SD medium.
messages: Receptor binding subunit of the a-agglutinin heterodimer. S.cerevisiae a and alpha cells express the complementary cell surface glycoproteins a-agglutinin and alpha-agglutinin, respectively, which interact with one another to promote cellular aggregation during mating.

559292:YNL334C
gene id: 559292:YNL334C
uniprot id: P53823
names: Function
names: Similarity
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform.

559292:YHR073W
gene id: 559292:YHR073W
uniprot id: P38713
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSBP family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with SCS2.
messages: Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:11238399, PubMed:15173322). May serve as a sensor of PI4P levels at PM-ER membrane contact site, regulating PI4P phosphatase SAC1 activity (PubMed:21295699). May be involved in ergosterol transport from the plasma membrane (PM) to the ER, however it does not bind sterols directly (PubMed:16585271, PubMed:23791945). Plays a role in the positive regulation of vesicular transport of ceramide from the ER to the Golgi, negatively regulating COPII-mediated ER export of cargos (PubMed:24213531).
messages: Present with 589 molecules/cell in log phase SD medium.
messages: The FFAT (two phenylalanines in an acidic tract) motif is required for interaction with SCS2 and proper localization of the protein.
messages: The GOLD (Golgi dynamics) domain is predicted to mediate diverse protein-protein interactions.
messages: The OSBP-related domain (ORD) mediates binding of sterols and phospholipids. It displays an incomplete beta-barrel containing a central hydrophobic tunnel that can accommodate a single lipid molecule with a flexible lid covering the tunnel entrance. The ORD can bind two membranes simultaneously. It has at least two membrane-binding surfaces; one near the mouth of the lipid-binding pocket and a distal site that can bind a second membrane. These structural features correlate with the phosphatidylinositol 4-phosphate (PI(4)P)-coupled lipid transport optimized in closely apposed membranes, such as organelle contact sites. The lipid transfer cycle starts from the association of the LTP with a donor membrane, which accompanies conformational changes that uncover the ligand-binding pocket. The tunnel opening is generally mediated by displacement of the lid covering the binding pocket allowing uptake or release of a lipid molecule. The LTPs extract the lipid from the membrane by providing a hydrophobic environment as well as specific interaction. Dissociation from the donor membrane shifts the conformation to a closed form. Then, the LTPs loaded with a cargo lipid diffuse through the aqueous phase. Lid opening may be induced by the interaction of a hydrophobic side of the lid with the target membranes (Probable). The OSH3 ORD does not accept sterols due to the small hydrophobic tunnel (PubMed:23791945).
messages: The PH domain weakly binds to phosphoinositides.

559292:YOR335C
gene id: 559292:YOR335C
uniprot id: P40825
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.
messages: Present with 33800 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at 2 upstream redundant non-AUG codons in-frame of the first AUG used for isoform Cytoplasmic.

559292:YLR248W
gene id: 559292:YLR248W
uniprot id: P38623
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by Ser-520 phosphorylation by HOG1.
messages: Autophosphorylated. Phosphorylated by HOG1 at Ser-520 after osmotic stress.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Cytoplasm
messages: Present with 1790 molecules/cell in log phase SD medium.
messages: Serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.

559292:YDR212W
gene id: 559292:YDR212W
uniprot id: P12612
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

559292:YHR188C
gene id: 559292:YHR188C
uniprot id: P38875
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGT family.
messages: Component of the GPI transamidase complex. Involved in transfer of GPI to proteins.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with CDC91, GPI17, GPI8 and GAA1.
messages: It is uncertain whether Met-1 or Met-9 is the initiator.
messages: Present with 1680 molecules/cell in log phase SD medium.
messages: The disulfide bond between GPI8 and GPI16 is important for normal enzyme activity.

559292:YCR045C
gene id: 559292:YCR045C
uniprot id: P25381
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: N-glycosylated.
messages: Spore wall
messages: Subtilisin-related protease involved in the formation of a protective dityrosine layer required for spore wall assembly. Identified in a screen for mutants with increased levels of rDNA transcription.

559292:YAR009C
gene id: 559292:YAR009C
uniprot id: O13527
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Transposon Ty1-A (YARCTy1-1) contains a frameshift at position 610, which disrupts the ORF coding for protein TY1B. This is the truncated, C-terminal part of TY1B translated from an in-frame start codon, and it is probably not functional.

559292:YOR257W
gene id: 559292:YOR257W
uniprot id: P06704
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the centrin family.
messages: Component of the spindle pole body (SPB), acting as the connector of microtubule arrays in the cytoplasm and the nucleoplasm, is involved in nuclear positioning before chromosome segregation, SPB separation, spindle formation, chromosome segregation, nuclear migration into the bud, nuclear reorientation after cytokinesis and nuclear fusion during conjugation. The SPB half-bridge, which is tightly associated with the cytoplasmic side of the nuclear envelope and the SPB, is playing a key role as the starting structure for and in the initiation of SPB duplication in G1. At the SPB half-bridge CDC31 interacts with KAR1, MPS3 and SFI1 (PubMed:12486115, PubMed:14504268). Interacts with KIC1 (PubMed:9813095). Interacts with VPS13 (PubMed:28122955). Associates with nuclear pore complexes (NPCs) (PubMed:10684247).
messages: Functions as a component of the spindle pole body (SPB) half-bridge (PubMed:10684247, PubMed:11156974, PubMed:12486115, PubMed:14504268, PubMed:8070654). At the SPB, it is recruited by KAR1 and MPS3 to the SPB half-bridge and involved in the initial steps of SPB duplication (PubMed:11156974, PubMed:12486115, PubMed:14504268, PubMed:8070654). Also involved in connection with the protein kinase KIC1 in the maintenance of cell morphology and integrity (PubMed:9813095). May play a role in vesicle-mediated transport, in a VPS13-dependent manner (PubMed:28122955).
messages: Nucleus envelope
messages: spindle pole body

559292:YDR179W-A
gene id: 559292:YDR179W-A
uniprot id: Q03983
names: Miscellaneous
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YDR341C
gene id: 559292:YDR341C
uniprot id: Q05506
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
messages: Monomer.
messages: Present with 20600 molecules/cell in log phase SD medium.
messages: cytosol

559292:YBL068W
gene id: 559292:YBL068W
uniprot id: P38063
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Cytoplasm
messages: Present with 5280 molecules/cell in log phase SD medium.

559292:YPL092W
gene id: 559292:YPL092W
uniprot id: P41930
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Cell membrane
messages: Involved in efflux of free sulfite. Mutations in the SSU1 gene cause sensitivity to sulfite.

559292:YJR002W
gene id: 559292:YJR002W
uniprot id: P47083
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MPP10 family.
messages: Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with snoRNA U3. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with the SSU processome subunits EMG1, IMP3, IMP4, KRR1, NOC4/UTP19, NOP1, RPS4A, RPS4B, RPS6A, RPS6B, RPS7A, RPS7B, RPS9A, RPS9B, RPS14A, RPS14B, UTP1-UTP18, UTP20-UTP22 and UTP25.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.
messages: nucleolus

559292:YNL014W
gene id: 559292:YNL014W
uniprot id: P53978
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm
messages: Decreases translation of proteins required for detoxification of reactive oxygen species (PubMed:33260587). Sensitive to hydrogen peroxide (PubMed:33260587). Increases GRX1 mRNA level during vegetative growth (PubMed:33260587). Normal vegetative cell population growth on glucose, galactose, and glycerol carbon sources, at high temperature, and at standard temperature (PubMed:9778796, PubMed:33260587). Normal mating and sporulation (PubMed:9778796).
messages: Expressed in vegetatively growing cells at very low levels.
messages: Increases in mild (0.5 mM) hydrogen peroxide stress, and decreases in stronger (1 mM) hydrogen peroxide stress.
messages: Monomer.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Ribosome-dependent ATPase that promotes the translation of proteins required for detoxification of reactive oxygen species (PubMed:33260587). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity).

559292:YPR117W
gene id: 559292:YPR117W
uniprot id: Q06116
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: Tube-forming lipid transport protein which may bind to phosphatidylinositols and may affect phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution.

559292:YEL059C-A
gene id: 559292:YEL059C-A
uniprot id: Q05676
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the mitochondrial inner membrane peptidase (IMP) complex which at least consists of IMP1, IMP2 and SOM1.
messages: Mitochondrion inner membrane
messages: Non-catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. SOM1 facilitates cleavage of a subset of IMP substrates.
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YFR044C
gene id: 559292:YFR044C
uniprot id: P43616
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulation of Cys-Gly dipeptide and enhanced GSH toxicity.
messages: Belongs to the peptidase M20A family.
messages: Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.
messages: Cytoplasm
messages: Homodimer. Component of the GSH degradosomal complex composed of at least DUG1, DUG2 and DUG3.
messages: Mitochondrion
messages: Present with 22300 molecules/cell in log phase SD medium.

559292:YPL129W
gene id: 559292:YPL129W
uniprot id: P35189
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF14 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID, the RNA polymerase II associated general transcription factor complex TFIIF, and the chromatin-remodeling complex SWI/SNF (PubMed:10788514, PubMed:12138208, PubMed:12516863, PubMed:9618449). Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation (PubMed:10788514, PubMed:12138208, PubMed:12516863, PubMed:9618449). TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (PubMed:10788514, PubMed:12138208, PubMed:12516863, PubMed:9618449). TFIIF is essential for the initiation of transcription by RNA polymerase II (PubMed:10788514, PubMed:12138208, PubMed:12516863, PubMed:9618449). TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation (PubMed:10788514, PubMed:12138208, PubMed:12516863, PubMed:9618449, PubMed:30385749). TAF14 acts as a chromatin reader that specifically recognizes and binds histones that are acylated (PubMed:26341557, PubMed:27089029). Recognizes and binds histone H3 acetylated or crotonylated at 'Lys-9' (H3K9ac and H3K9cr, respectively), with some preference for crotonylated lysine (PubMed:26341557, PubMed:27089029, PubMed:30385749). Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes (PubMed:12672490). It changes chromatin structure by altering DNA-histone contacts within a…
messages: Nucleus
messages: Present with 3100 molecules/cell in log phase SD medium.
messages: TAF14 is the only non-essential TAF.
messages: The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. TFIIF is composed of three different subunits: TFG1/RAP74, TFG2/RAP30 and TAF14. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29. Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6.
messages: The YEATS domain specifically recognizes and binds acylated histones (acetylated and crotonylated) (PubMed:26341557, PubMed:27089029, PubMed:30385749). Binds crotonylated lysine through a non-canonical pi-pi-pi stacking mechanism (PubMed:27089029, PubMed:30385749).
messages: There is no homolog of TAF14 present in the TFIIF complexes of higher eukaryotes.

559292:YBL108C-A
gene id: 559292:YBL108C-A
uniprot id: Q3E770
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YDL002C
gene id: 559292:YDL002C
uniprot id: Q03435
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.
messages: Nucleus
messages: Present with 1750 molecules/cell in log phase SD medium.
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

559292:YPL014W
gene id: 559292:YPL014W
uniprot id: Q02606
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

559292:YDR461W
gene id: 559292:YDR461W
uniprot id: P34165
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Present with 28900 molecules/cell in log phase SD medium.
messages: The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A.

559292:YNR037C
gene id: 559292:YNR037C
uniprot id: P53733
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion

559292:YOR152C
gene id: 559292:YOR152C
uniprot id: Q99325
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a receptor for reticulophagy. Directs autophagic sequestration of folded tubules/sheets derived from the cortical endoplasmic reticulum (cER) and the cytoplasmic endoplasmic reticulum (cytoER) into autophagosomes. Is not required for the cytoplasm-to-vacuole targeting pathway, mitophagy, pexophagy, and non-selective autophagy.
messages: Endoplasmic reticulum membrane
messages: Induced in absence of NAP1 (PubMed:12788058). Expression is increased by rapamycin, which mimics nitrogen starvation by inactivating the TORC1 complex (PubMed:26040717).
messages: Interacts with ATG8 and ATG11.
messages: Partially blocks reticulophagy, and the double ATG39/ATG40 knockout almost completely blocks this pathway. Leads to a more densely reticulated cytoplasmic endoplasmic reticulum (cER).
messages: Preautophagosomal structure membrane
messages: Present with 1890 molecules/cell in log phase SD medium.

559292:YOR378W
gene id: 559292:YOR378W
uniprot id: Q08902
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Does not affect boron tolerance (PubMed:19414602). Impairs methylammonium (MA) transport and toxicity (PubMed:24707045).
messages: Expression is induced by neocarzinostatin (PubMed:11562456). Expression is induced during G2 phase of cell cycle (PubMed:16278933). Expression is slightly up-regulated upon exposure to boric acid (PubMed:19414602). The AMF1 promoter contains 8 predicted enhancer box (E-box) transcription factor binding domains (PubMed:24707045).
messages: Low affinity ammonium transporter of the plasma membrane (PubMed:24707045). May be involved in drug resistance through pumping them out of the cell (By similarity).

559292:YER134C
gene id: 559292:YER134C
uniprot id: P40081
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Cytoplasm
messages: Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.
messages: Nucleus
messages: Present with 6190 molecules/cell in log phase SD medium.

559292:YBR003W
gene id: 559292:YBR003W
uniprot id: P18900
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species.
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Mitochondrion inner membrane
messages: Present with 1560 molecules/cell in log phase SD medium.

559292:YMR316W
gene id: 559292:YMR316W
uniprot id: P54005
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in regulation of invasive growth.
messages: Present with 736 molecules/cell in log phase SD medium.

559292:YLR014C
gene id: 559292:YLR014C
uniprot id: P07272
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Positive regulator of URA1 and URA3 expression.

559292:YLR315W
gene id: 559292:YLR315W
uniprot id: Q06162
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKP2 family.
messages: Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:22561346). NKP1 interacts directly with OKP1 and AME1 (By similarity).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Nucleus
messages: Present with 1630 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YDL004W
gene id: 559292:YDL004W
uniprot id: Q12165
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

559292:YNL021W
gene id: 559292:YNL021W
uniprot id: P53973
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Present with 3050 molecules/cell in log phase SD medium.
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

559292:YNL132W
gene id: 559292:YNL132W
uniprot id: P53914
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with TAN1 (PubMed:25653167). Associates with 90S pre-ribosomal particles (PubMed:12150911).
messages: Leads to a strong inhibition of 18S rRNA synthesis (PubMed:25653167). Deletion results in an altered alkali-soluble beta-glucan phenotype (PubMed:12150911). Heterozygous mutants show haploinsufficiency in K1 killer toxin resistance (PubMed:12663529).
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1280 and 1773 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25086048, PubMed:25653167). Catalyzes the formation of ac4C at position 12 in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167).
messages: nucleolus

559292:YPR111W
gene id: 559292:YPR111W
uniprot id: P32328
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Is probably a Ser/Thr-protein kinase that may function in initiation of DNA synthesis and also in late nuclear division.
messages: Present with 3320 molecules/cell in log phase SD medium.

559292:YJL012C
gene id: 559292:YJL012C
uniprot id: P47075
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity of the enzyme is Mn(2+)-dependent and enhanced in the presence of pyrophosphate (PPi).
messages: Belongs to the VTC4 family.
messages: By low phosphate.
messages: Catalytic subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046). The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046). PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834). The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419, PubMed:12584253). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules. Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106). The VTC complex is required for microautophagy. It is a constituent of autophagic tubes and is required for scission of microautophagic vesicles from these tubes (PubMed:17079729).
messages: Endoplasmic reticulum membrane
messages: Present with 8710 molecules/cell in log phase SD medium.
messages: The SPX domain has very high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7), and moderate affinity for inorganic pyrophosphate. Its affinity for inorganic phosphate is 2 to 3 orders of magnitude lower (Probable). SPX domains may integrate inositol pyrophosphates (PP-InsP)-dependent signaling to adapt cytosolic phosphate concentrations to different metabolic situations (Probable).
messages: The VTC core complex is an integral membrane heterooligomer composed of the catalytic subunit VTC4 and the accessory subunits VTC1, VTC2 and VTC3. The complex exists in 2 different sub-complexes: VTC1-VTC2-VCT4 and VCT1-VTC3-VTC4. The VCT1-VTC3-VTC4 subcomplex is mostly found on the vacuolar membrane. The VTC1-VTC2-VCT4 subcomplex is observed in the cell periphery, probably ER and nuclear envelope, but localizes to the vacuole under phosphate starvation. Each subunit contains 3 transmembrane helices. VTC1 is a small membrane protein without hydrophilic domain. VTC2, VTC3 and VTC4 are related and have 2 hydrophilic domains that face the cytosol, an N-terminal SPX domain and the central core domain. The central core in VTC4 is the catalytic domain, with the essential catalytic lysine replaced by isoleucine and leucine in VTC2 and VTC3, respectively (PubMed:19390046). The core complex associates with the accessory subunit VTC5 (PubMed:27587415). The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1 (PubMed:11823419).
messages: Vacuole membrane
messages: autophagosome membrane
messages: cell cortex

559292:YOR233W
gene id: 559292:YOR233W
uniprot id: Q01919
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Present with 143 molecules/cell in log phase SD medium.
messages: This protein is probably a serine/threonine protein kinase.

559292:YDR261C-C
gene id: 559292:YDR261C-C
uniprot id: O74302
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR4 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YKR059W
gene id: 559292:YKR059W
uniprot id: P10081
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A (TIF1/TIF2), eIF4E (TIF45) and eIF4G (TIF4631 or TIF4632) (By similarity). Interacts with eIF4G1/TIF4631 and eIF4G2/TIF4632.
messages: Cytoplasm
messages: Present with 106000 molecules/cell in log phase SD medium.
messages: TIF1 and TIF2 code for the same protein.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

559292:YDR253C
gene id: 559292:YDR253C
uniprot id: Q12041
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Auxiliary transcriptional regulator of sulfur amino acid metabolism. Involved in the transcriptional activation of MET28.
messages: Cytoplasm
messages: Interacts with MET4 and MET28.
messages: Nucleus

559292:YKL005C
gene id: 559292:YKL005C
uniprot id: P36106
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BYE1 family.
messages: Interacts with the RNA polymerase RPB1 subunit and specifically with the trimethylated H3 histone H3K4me3.
messages: Negative regulator of transcription elongation.
messages: Nucleus
messages: Present with 892 molecules/cell in log phase SD medium.
messages: The PHD domain is involved in the binding to H3K4me3.

559292:YOR283W
gene id: 559292:YOR283W
uniprot id: Q12040
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Cytoplasm
messages: Metal-independent phosphatase active against a broad range of phosphorylated substrates including nucleoside tri- and diphosphates, phosphorylated organic acids, and amino acids. Shows no activity against phytic acid, phosphorylated carbohydrates, and nucleoside monophosphates.
messages: Nucleus
messages: Present with 8300 molecules/cell in log phase SD medium.

559292:YHL004W
gene id: 559292:YHL004W
uniprot id: P32902
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 6890 molecules/cell in log phase SD medium.

559292:YNL148C
gene id: 559292:YNL148C
uniprot id: P53904
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts to sequester alpha-tubulin from interaction with beta-tubulin, raising the possibility that it plays a regulatory role in the formation of the tubulin heterodimer.
messages: Belongs to the TBCB family.
messages: Binds to monomeric alpha-tubulin.
messages: Cytoplasm
messages: Present with 656 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YPR008W
gene id: 559292:YPR008W
uniprot id: Q12753
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 339 molecules/cell in log phase SD medium.
messages: Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper.

559292:YHR207C
gene id: 559292:YHR207C
uniprot id: P38890
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Present with 5000 molecules/cell in log phase SD medium.
messages: Putative protein lysine methyltransferase that acts as a virus host factor involved in the replication of positive-strand RNA viruses like the MBV.

559292:YGR148C
gene id: 559292:YGR148C
uniprot id: P24000
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 36900 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL24 in yeast.

559292:YKL063C
gene id: 559292:YKL063C
uniprot id: P35725
names: Miscellaneous
messages: Present with 2190 molecules/cell in log phase SD medium.

559292:YFR017C
gene id: 559292:YFR017C
uniprot id: P43598
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an inhibitor of GDB1, enhancing the ability of cells to store glucose as glycogen.
messages: Cytoplasm
messages: Expression increases during wine fermentation.
messages: Interacts with GDB1.
messages: Present with 639 molecules/cell in log phase SD medium.

559292:YMR218C
gene id: 559292:YMR218C
uniprot id: Q03660
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM1 family.
messages: Golgi apparatus
messages: Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS120 and TRS130. Interacts with YPT31 and YPT32.
messages: Present with 432 molecules/cell in log phase SD medium.
messages: Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchange factor (GEF) for the Golgi YPT1 GTPase. TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120. Required for both the cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy through its role in ATG8 and ATG9 trafficking.

559292:YDR502C
gene id: 559292:YDR502C
uniprot id: P19358
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Heterotetramer.
messages: In yeast, there are two genes coding for AdoMet synthase.
messages: Present with 22000 molecules/cell in log phase SD medium.

559292:YDL087C
gene id: 559292:YDL087C
uniprot id: Q07508
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Luc7 family.
messages: Component of the 18S U1 snRNP particle, a subcomplex of the spliceosome.
messages: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
messages: Nucleus
messages: Present with 2270 molecules/cell in log phase SD medium.

559292:YFR002W
gene id: 559292:YFR002W
uniprot id: P34077
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NIC96 is part of three NPC subcomplexes, interacting with NSP1 of the NUP57 subcomplex (NIC96, NSP1, NUP49, NUP57), with NUP120 of the NUP84 subcomplex (SEH1, NUP85, NUP120, NUP145C, SEC13, NUP84, NUP133), and with NUP53 of the NUP53-NUP59-NUP170 subcomplex. The interaction with NUP53 is cell cycle dependent. NIC96 is also associated with the distal ring of the nuclear basket and interacts here with MLP2, which forms together with MLP1 nuclear pore-attached intranuclear filaments.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NIC96, which is localized to the core of the NPC and the distal ring of the nuclear basket, is required for de novo assembly of NPCs. It is involved in nuclear GSP1 import.
messages: Nucleus membrane
messages: Present with 15500 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YGL053W
gene id: 559292:YGL053W
uniprot id: P53174
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DUP/COS family.
messages: Endoplasmic reticulum
messages: Interacts with PRM9. Binds to SEC23/24 of COPII coated vesicles.
messages: May be involved in endoplasmic reticulum exit trafficking of proteins.
messages: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.
messages: Membrane
messages: Present with 1254 molecules/cell in log phase SD medium.

559292:YML081W
gene id: 559292:YML081W
uniprot id: Q04545
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSF2/TDA9 family.
messages: DNA-binding protein that acts probably as a transcription factor.
messages: Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.
messages: Nucleus
messages: Present with 672 molecules/cell in log phase SD medium.

559292:YHL020C
gene id: 559292:YHL020C
uniprot id: P21957
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Interacts with SCS2.
messages: Negative regulator of the transcriptional complex INO2-INO4 in response to phospholipid precursor availability. When precursors become limiting, OPI1 is retained at the endoplasmic reticulum (ER) and INO2-INO4 activates INO1 and other genes required for phospholipid biosynthesis, whereas abundant precursor availability results in targeting of OPI1 to the nucleus to repress transcription of these genes. Binds directly to phosphatidic acid, which is required for ER targeting and may act as sensing mechanism for precursor availability, as phosphatidic acid becomes rapidly depleted upon phospholipid biosynthesis.
messages: Nucleus
messages: Present with 1281 molecules/cell in log phase SD medium.
messages: The FFAT motif is required for interaction with SCS2 and proper localization of the protein.

559292:YHR079C
gene id: 559292:YHR079C
uniprot id: P32361
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated mainly on serine residues.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; in response to the accumulation of unfolded proteins.
messages: Present with 259 molecules/cell in log phase SD medium.
messages: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.
messages: The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.

559292:YML112W
gene id: 559292:YML112W
uniprot id: P46963
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTK3 family.
messages: CTDK-I consists of three subunits, CTK1, CTK2 and CTK3 (also called alpha, beta and gamma). Interacts with CTK1. Heterodimerization with CTK2 is required to protect this subunit from degradation.
messages: Cytoplasm
messages: Gamma subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase I transcription and RNA polymerase II transcriptional elongation, and as part of the CTDK-I complex, pre-mRNA 3'-end processing and SET2 mediated H3K36 methylation. Together with CTK2, required for CTK1 CTD kinase activation. Required for DNA damage induced transcription. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus.
messages: Null mutants are viable, but grow more slowly than wild-type cells at 30 degrees Celsius. They are cold-sensitive, failing to grow at 12 degrees Celsius. They display flocculent growth in liquid media and they show abnormal cell morphologies, for example, a significant fraction of the cells are greatly enlarged. Deletion mutant is sensitive to the DNA synthesis inhibitor hydroxyurea (HU) and UV irradiation.
messages: Present with 2640 molecules/cell in log phase SD medium.
messages: Ubiquitinated. Ubiquitination leads to degradation by the 26S proteasome pathway.
messages: nucleolus

559292:YLR348C
gene id: 559292:YLR348C
uniprot id: Q06143
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Homodimer. Binds to the TIM22 translocation complex during import.
messages: Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate. Required for growth on ethanol and acetate.
messages: Mitochondrion inner membrane
messages: Present with 3390 molecules/cell in log phase SD medium.
messages: The C-terminal Solcar repeat is required for association with the TIM22 translocation complex during import.

559292:YDR173C
gene id: 559292:YDR173C
uniprot id: P07250
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inositol phosphokinase (IPK) family.
messages: Impairs nuclear mRNA export, slows cell growth, increases cellular InsP3 170-fold and decreases InsP6 100-fold.
messages: Inositol phosphate kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activities. Able to phosphorylate inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) on both the carbon-3 and carbon-6 positions to synthesize inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) and inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), and then to subsequently phosphorylate and convert either isomer of InsP4 to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:10574768, PubMed:10683435, PubMed:11311242). Its predominant in vivo catalytic function is to convert Ins(1,4,5)P3 to Ins(1,4,5,6)P4 to Ins(1,3,4,5,6)P5 via 6- and 3-kinase activities (PubMed:15944147). It can also use Ins(1,3,4,5,6)P5 as a substrate and act as a diphosphoinositol polyphosphate synthase to generate two different isomers of PP-InsP4 (PubMed:11311242). Has also a role in transcription regulation. Forms a complex with ARG80, ARG81 and MCM1 (ArgR-MCM1), which coordinates the expression of arginine anabolic and catabolic genes in response to arginine. Recruits ARG80 and MCM21 to stabilize them (PubMed:3298999, PubMed:8043104, PubMed:10632874). Neither the kinase activity nor inositol phosphates are required for the formation of ArgR-MCM1 transcriptional complexes on DNA promoter elements and the control of arginine metabolism (PubMed:11119723, PubMed:10720331, PubMed:12828642, PubMed:22992733). In contrast, only the catalytic activity is required for PHO gene repression by phosphate and for NCR gene activation in response to nitrogen availability, indicating a role for inositol pyrophosphates in these controls (PubMed:12828642). Inositol polyphosphates may be involved in the regulation of chromatin remodeling of transcription (PubMed:12434012). Regulates nuclear mRNA export via inositol phosphate metabolism (PubMed:10390371, PubMed:10683435). Also has lipid kinase activity, transforming the lipid inositol phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) into phosphatidylinosi…
messages: Interacts with ARG80 and MCM1.
messages: Nucleus
messages: Present with 2720 molecules/cell in log phase SD medium.
messages: The expression of this protein is not effected by the presence of arginine.

559292:YOR365C
gene id: 559292:YOR365C
uniprot id: Q08844
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

559292:YOR020W-A
gene id: 559292:YOR020W-A
uniprot id: Q3E824
names: Subcellular Location Annotation
messages: Mitochondrion membrane

559292:YMR102C
gene id: 559292:YMR102C
uniprot id: Q03177
names: Miscellaneous
names: Similarity
messages: Belongs to the WD repeat DGR2 family.
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YJR079W
gene id: 559292:YJR079W
uniprot id: P47126
names: Miscellaneous
messages: Present with 907 molecules/cell in log phase SD medium.

559292:YER094C
gene id: 559292:YER094C
uniprot id: P25451
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. This subunit may participate in the trypsin-like activity of the enzyme complex.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

559292:YGL178W
gene id: 559292:YGL178W
uniprot id: P39016
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 1240 molecules/cell in log phase SD medium.
messages: RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of HO by binding to the 3'-UTR of HO mRNA. Predominantly binds to mRNAs encoding chromatin modifiers and spindle pole body components. Recognizes and binds to 5'-TGTAA[CT]A[AT]TA-3' in the 3'-UTR of target mRNAs. Multicopy suppressor of POP2 mutation. Required for high temperature growth.

559292:YNL240C
gene id: 559292:YNL240C
uniprot id: P23503
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NARF family.
messages: Cytoplasm
messages: Essential component of a cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.
messages: Interacts with CIA1.
messages: Nucleus

559292:YNR043W
gene id: 559292:YNR043W
uniprot id: P32377
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:8626466, PubMed:9244250). MVD1/ERG19 converts diphosphomevalonate into isopentenyl diphosphate (PubMed:8626466). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672).
messages: Homodimer.
messages: Present with 13700 molecules/cell in log phase SD medium.

559292:YDR068W
gene id: 559292:YDR068W
uniprot id: P54858
names: Function
names: Miscellaneous
messages: Acts in ubiquitin metabolism and is necessary for the control of single-copy DNA replication.
messages: Present with 3270 molecules/cell in log phase SD medium.

559292:YLR130C
gene id: 559292:YLR130C
uniprot id: Q12436
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Inhibited by Cu(2+) and Fe(3+) ions.
messages: Low-affinity zinc transport protein. Active in zinc-replete cells and is time-, temperature- and concentration-dependent and prefers zinc over other metals as its substrate.
messages: Membrane

559292:YER132C
gene id: 559292:YER132C
uniprot id: P32634
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Negatively regulates early sporulation-specific genes. Seems to exert its function by positively regulating the Ras/cAMP pathway. Required for growth under alkaline conditions. Acts synergetically with MDS3.
messages: Present with 815 molecules/cell in log phase SD medium.

559292:YNR033W
gene id: 559292:YNR033W
uniprot id: P37254
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.
messages: Present with 1550 molecules/cell in log phase SD medium.
messages: The PABA component provides the glutamine amidotransferase activity.
messages: The PABB component catalyzes the formation of ADC by binding chorismate and ammonia.

559292:YCR038C
gene id: 559292:YCR038C
uniprot id: P25300
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: GDP-GTP exchange factor (GEF) for the small GTPase BUD1/RSR1. Regulates the activity of BUD1 together with BUD2 which is a GTPase-activating protein (GAP) of BUD1. Required to produce both the axial and bipolar patterns of bud site selection. Determines the orientation of division axis. Overexpression can suppress mutations in PRP20 which is the GEF for GSP1. May be a cytoplasmic GEF for GSP1. Might also act on the Ras-like protein CDC42. Appears to bind to Ras proteins but not to activate them.
messages: Interacts with AXL2, BEM1, GSP1 and in haploid cells with AXL1.
messages: Present with 2110 molecules/cell in log phase SD medium.
messages: cell cortex

559292:YMR012W
gene id: 559292:YMR012W
uniprot id: Q03690
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLU family.
messages: Causes mitochondria to cluster within cells.
messages: Cytoplasm
messages: Expression is increased in intermediate compared to fully aerobic conditions.
messages: May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex. Associates with the 80S ribosome.
messages: Present with 17000 molecules/cell in log phase SD medium.
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

559292:YNL134C
gene id: 559292:YNL134C
uniprot id: P53912
names: Miscellaneous
names: Similarity
messages: Belongs to the YCR102c/YLR460c/YNL134c family.
messages: Present with 3490 molecules/cell in log phase SD medium.

559292:YKL151C
gene id: 559292:YKL151C
uniprot id: P36059
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Cytoplasm
messages: Present with 3870 molecules/cell in log phase SD medium.

559292:YKL055C
gene id: 559292:YKL055C
uniprot id: P35731
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Involved in biosynthesis of fatty acids in mitochondria.
messages: Mitochondrion
messages: Present with 1760 molecules/cell in log phase SD medium.

559292:YLR135W
gene id: 559292:YLR135W
uniprot id: Q12098
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX4 family.
messages: Cytoplasm
messages: Forms a heterodimer with SLX1. Interacts with RAD1; catalytic subunit of the RAD1-RAD10 endonuclease. Interacts with RTT107.
messages: Nucleus
messages: Phosphorylated by ATR (MEC1) and ATM (TEL1) upon DNA damage. This appears to be required for the function with the RAD1-RAD10 endonuclease.
messages: Present with 274 molecules/cell in log phase SD medium.
messages: Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro. Interacts with the structure-specific RAD1-RAD10 endonuclease and promotes RAD1-RAD10-dependent 3'-non-homologous tail removal (NHTR) during repair of double-strand breaks by single-strand annealing. SLX4 also promotes recovery from DNA-alkylation-induced replisome stalling during DNA replication by facilitating the error-free mode of lesion bypass. This does not require SLX1 or RAD1-RAD10, but probably RTT107.

559292:YMR228W
gene id: 559292:YMR228W
uniprot id: P14908
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Although strongly related to dimethyladenosine transferase proteins, it lacks the methyltransferase activity. Dimethyladenosine transferase methylates the 2 adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA in most species. This explains why 12S rRNA is not methylated in S.cerevisiae.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.
messages: Mitochondrion intermembrane space
messages: Present with 9380 molecules/cell in log phase SD medium.

559292:YKL120W
gene id: 559292:YKL120W
uniprot id: P32332
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Present with 5350 molecules/cell in log phase SD medium.
messages: Transports oxaloacetate and sulfate.

559292:YML053C
gene id: 559292:YML053C
uniprot id: Q04978
names: Miscellaneous
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YLR059C
gene id: 559292:YLR059C
uniprot id: P54964
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Mitochondrion
messages: Present with 1730 molecules/cell in log phase SD medium.

559292:YHR066W
gene id: 559292:YHR066W
uniprot id: P38789
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.
messages: Present with 8150 molecules/cell in log phase SD medium.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

559292:YKL010C
gene id: 559292:YKL010C
uniprot id: P33202
names: Function
names: Miscellaneous
names: Similarity
messages: A cysteine residue is required for ubiquitin-thioester formation.
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: Present with 7380 molecules/cell in log phase SD medium.

559292:YER171W
gene id: 559292:YER171W
uniprot id: P06839
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/RAD3 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. XPD/RAD3 acts by forming a bridge between TFIIK and the core-TFIIH complex. Involved in the maintenance of the fidelity of DNA replication.
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Nucleus
messages: Present with 14400 molecules/cell in log phase SD medium.

559292:YGL043W
gene id: 559292:YGL043W
uniprot id: P07273
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Can promote the transfer of one strand of a double-stranded DNA molecule to a homologous single strand and thus may be involved in recombination.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus
messages: Present with 6260 molecules/cell in log phase SD medium.
messages: S-II binds to RNA-polymerase II in the absence of transcription.

559292:YGR112W
gene id: 559292:YGR112W
uniprot id: P53266
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SURF1 family.
messages: Interacts with COA1, COX14 and MSS51.
messages: Mitochondrion inner membrane
messages: Present with 623 molecules/cell in log phase SD medium.
messages: Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step that couples MSS51-COX14-dependent regulation of COX1 translation to early steps of cytochrome c oxidase assembly.

559292:YGR004W
gene id: 559292:YGR004W
uniprot id: P53203
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEX28-32 family. PEX30/31 subfamily.
messages: Peroxisome membrane
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YKL196C
gene id: 559292:YKL196C
uniprot id: P36015
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cell membrane

559292:YPR061C
gene id: 559292:YPR061C
uniprot id: Q12350
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaJ family.
messages: Mitochondrion membrane
messages: Present with 414 molecules/cell in log phase SD medium.
messages: Probable chaperone.

559292:YPL023C
gene id: 559292:YPL023C
uniprot id: P46151
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

559292:YCR076C
gene id: 559292:YCR076C
uniprot id: P25659
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Interacts with the 20S proteasome.
messages: Plays a role in the establishment of transcriptional silencing boundaries, preventing the propagation of heterochromatic silencing.
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YBL100W-B
gene id: 559292:YBL100W-B
uniprot id: Q12491
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YBL100W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YJL029C
gene id: 559292:YJL029C
uniprot id: P47061
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS53 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts also with TLG1, YPT6 and ARL1.
messages: Endosome membrane
messages: Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.
messages: trans-Golgi network membrane

559292:YGL205W
gene id: 559292:YGL205W
uniprot id: P13711
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA oxidase family.
messages: Homooctamer.
messages: Peroxisome

559292:YDR334W
gene id: 559292:YDR334W
uniprot id: Q05471
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
messages: Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Component of the SWR1 chromatin-remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.
messages: Nucleus
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YIL105C
gene id: 559292:YIL105C
uniprot id: P40485
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Heterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5-bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2.
messages: Phosphorylated by the target of rapamycin complex 2 (TORC2) and dephosphorylated by serine/threonine-protein phosphatase 2B (calcineurin).
messages: Present with 5190 molecules/cell in log phase SD medium.
messages: Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.

559292:YGL173C
gene id: 559292:YGL173C
uniprot id: P22147
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 3'-phosphoadenosine 5'-phosphate (pAp) is an inhibitor of KEM1. Sodium-induced GCN4 expression reduces pAp accumulation by activating HAL2 expression, and therefore maintains mRNA degradation capacity which is likely to be important for the accurate and rapid adaptation of gene expression to salt stress.
messages: Belongs to the 5'-3' exonuclease family.
messages: Both strand exchange and nuclease activities require magnesium, for the strand exchange activity, calcium can replace magnesium when the linear ds-DNA has been first resected with an exogenous endonuclease.
messages: Cytoplasm
messages: Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. The NMD pathway has a second role regulating the decay of wild-type mRNAs, and especially mRNAs that are important for telomere functions. Participate in CTH2-mediated and VTS1-mediated mRNA turnover. Involved in the degradation of several hypomodified mature tRNA species and participates in the 5'-processing or the degradation of the snoRNA precursors and rRNA processing. Involved in defense against virus and suppresses viral RNA recombination by rapidly removing the 5'-truncated RNAs, the substrates of recombination, and thus reducing the chance for recombination to occur in the parental strain. Required for the assembly of the virus-like particles of the Ty3 retrotransposon and contributes to the efficient generation of narnavirus 20S RNA by playing a major role in the elimination of the non-viral upstream sequences from the primary transcripts. Degrades single-stranded DNA (ss-DNA) and can renature complementary ss-DNA as well as catalyzes the formation of heteroduplex DNA from circular ss-DNA and homologous linear ds-DNA in vitro. Acts as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin and promotes in vitro assembly of tubulin into microtubules. Associates with microtubule functions such as chromosome transmission, nuclear migration, and SPB duplication. Has also a role in G1 to S transition and is involved in nuclear fusion during karyogamy. Required for the expression of ROK1 at the post-transcriptional level and for the alpha-factor induction of the karyogamy genes KAR3 and KAR4. Plays a role …
messages: Mutations affect nuclear fusion, leed to reduced chromosome stability and defects in spindle pole body duplication and/or separation as well as loss of viability under conditions of nitrogen starvation. Homozygous diploids are unable to sporulate. Leads also to arrest in pachytene and deficiency in meiotic recombination and sensitivity to oleate.
messages: P-body
messages: Present with 11700 molecules/cell in log phase SD medium.
messages: perinuclear region

559292:YHL009W-A
gene id: 559292:YHL009W-A
uniprot id: Q6Q5P6
names: Function
names: Miscellaneous
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty4 retrotransposons belong to the copia elements (pseudoviridae).

559292:YDR026C
gene id: 559292:YDR026C
uniprot id: Q12457
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding protein that recognizes sequence-specific replication termini (Ter sites) within rDNA (PubMed:14576157). Binds to rDNA terminator elements and mediates efficient RNA polymerase I transcription termination (PubMed:22805593). Required for rDNA silencing at the non-transcribed spacer 1 (NTS1). Promotes the association of SIR2 with NTS1 and contributes to maintenance of rDNA stability (PubMed:22362748).
messages: Decreases the association of SIR2 with NTS1, decreases rDNA stability and shortens replicative lifespan.
messages: Interacts with FOB1 (PubMed:14576157, PubMed:22362748). Interacts with the RENT complex subunits NET1 and SIR2 (PubMed:22362748).
messages: Present with 432 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR498C
gene id: 559292:YDR498C
uniprot id: P28791
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC20 family.
messages: Component of a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6. Interacts with TIP20 through its cytoplasmic domain.
messages: Endoplasmic reticulum membrane
messages: O-glycosylated, but not N-glycosylated.
messages: Present with 4910 molecules/cell in log phase SD medium.
messages: SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

559292:YNL011C
gene id: 559292:YNL011C
uniprot id: P53980
names: Miscellaneous
messages: Present with 1100 molecules/cell in log phase SD medium.

559292:YJL062W-A
gene id: 559292:YJL062W-A
uniprot id: Q3E7B2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes composed at least COA3, COX14, COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51.
messages: Mitochondrion inner membrane
messages: Present with 2530 molecules/cell in log phase SD medium.
messages: Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1.

559292:YKL128C
gene id: 559292:YKL128C
uniprot id: P36069
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 3250 molecules/cell in log phase SD medium.
messages: Probable phosphomutase that may have a function related to the manipulation of phosphate groups on carbohydrates. Reduces trehalose-6-phosphate levels when overexpressed in TPS2-deleted cells. Reduces 5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR) levels, a metabolic intermediate at the crossroads between AMP and histidine biosynthesis pathways, when overexpressed in a ADE3-ADE16-ADE17 triple deletant.

559292:YDL019C
gene id: 559292:YDL019C
uniprot id: Q12451
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSBP family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with SCS2.
messages: Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:15173322). Binds and transports sterol (PubMed:20008566). Plays a role in the positive regulation of vesicular transport of ceramide from the ER to the Golgi, negatively regulating COPII-mediated ER export of cargos (PubMed:24213531).
messages: Present with 1069 molecules/cell in log phase SD medium.
messages: The FFAT (two phenylalanines in an acidic tract) motif is required for interaction with SCS2 and proper localization of the protein.
messages: The OSBP-related domain (ORD) mediates binding of sterols and phospholipids. It displays an incomplete beta-barrel containing a central hydrophobic tunnel that can accommodate a single lipid molecule with a flexible lid covering the tunnel entrance. The ORD can bind two membranes simultaneously. It has at least two membrane-binding surfaces; one near the mouth of the lipid-binding pocket and a distal site that can bind a second membrane. These structural features correlate with the phosphatidylinositol 4-phosphate (PI(4)P)-coupled lipid transport optimized in closely apposed membranes, such as organelle contact sites. The lipid transfer cycle starts from the association of the LTP with a donor membrane, which accompanies conformational changes that uncover the ligand-binding pocket. The tunnel opening is generally mediated by displacement of the lid covering the binding pocket allowing uptake or release of a lipid molecule. The LTPs extract the lipid from the membrane by providing a hydrophobic environment as well as specific interaction. Dissociation from the donor membrane shifts the conformation to a closed form. Then, the LTPs loaded with a cargo lipid diffuse through the aqueous phase. Lid opening may be induced by the interaction of a hydrophobic side of the lid with the target membranes.
messages: The PH domain strongly binds to phosphoinositides and is required for targeting the protein to the membrane.

559292:YPR035W
gene id: 559292:YPR035W
uniprot id: P32288
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Homooctamer.
messages: Present with 346000 molecules/cell in log phase SD medium.
messages: The submitted sequence does not correspond to the sequence published in the paper.

559292:YNR051C
gene id: 559292:YNR051C
uniprot id: P53741
names: Function
names: Miscellaneous
names: Subunit
messages: Has a role in de-ubiquitination. In conjunction with UBP3, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of sec23.
messages: Heterotetramer with UBP3; contains two molecules of BRE5 and two molecules of UBP3 (PubMed:12778054, PubMed:17632125). Forms a complex composed of CDC48, DOA1, deubiquitinase UBP3 and probably BRE5 (PubMed:20508643). Within the complex, interacts (via C-terminus) with CDC48; the interaction is direct and UBP3-independent (PubMed:20508643).
messages: Present with 11700 molecules/cell in log phase SD medium.

559292:YOR385W
gene id: 559292:YOR385W
uniprot id: Q08909
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YIL045W
gene id: 559292:YIL045W
uniprot id: P40187
names: Function
names: Miscellaneous
messages: Interacts with glycogen synthase 2 (GSY2); possibly also interacts with phosphatase 1 (GLC7).
messages: Present with 996 molecules/cell in log phase SD medium.

559292:YNL225C
gene id: 559292:YNL225C
uniprot id: P53865
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts directly with ADY3 and YOR129C. Interacts with ADY4. Probable component of a SPB complex composed of ADY3, SSP1, DON1, MPC54, SPO21/MPC70, NUD1 and CNM67.
messages: Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. Required for the proper formation of the spindle pole body (SPB) outer plaque. May connect the outer plaque to the central plaque embedded in the nuclear envelope.
messages: Meiosis-specific. Expressed from 3 to 9 hours after induction of sporulation.
messages: Phosphorylated in its N-terminal part.
messages: The length of the coiled coil are required to adjust the space between outer plaque and the central plaque.
messages: spindle pole body

559292:YHR215W
gene id: 559292:YHR215W
uniprot id: P38693
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the histidine acid phosphatase family.
messages: Glycosylated during secretion across the membrane.
messages: Present with 3290 molecules/cell in log phase SD medium.
messages: S.cerevisiae has 2 types of acid phosphatase: one is constitutive and the other is repressible by inorganic phosphate.

559292:YLR442C
gene id: 559292:YLR442C
uniprot id: P06701
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer and interacts with SIR4 and RAP1 C-terminus. Interacts with MCM10.
messages: N-terminal acetylation by NatA is important for transcriptional silencing activity.
messages: Nucleus
messages: Present with 1400 molecules/cell in log phase SD medium.
messages: The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.

559292:YNR001C
gene id: 559292:YNR001C
uniprot id: P00890
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Decreased growth related to mitochondrial dysfunction.
messages: Mitochondrion matrix
messages: Monomer and homodimer (PubMed:28076776). Exists as an inactive monomer when phosphorylated (PubMed:28076776). Homodimerization is dependent on dephosphorylation of Ser-462 by PTC7 and is required for activity (PubMed:28076776).
messages: Phosphorylation at Ser-462 inhibits catalytic activity. Dephosphorylation at Ser-462 by PTC7 enhances catalytic activity.
messages: Phosphorylation at Ser-462. Dephosphorylated at Ser-462 by PTC7.
messages: Specific citrate synthase with catalytic activity only with acetyl-CoA.

559292:YDL213C
gene id: 559292:YDL213C
uniprot id: Q07623
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NOP6 family.
messages: Predicted to be involved in rRNA processing.
messages: Present with 8970 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YBR272C
gene id: 559292:YBR272C
uniprot id: P38348
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the proteasome subunit S5B/HSM3 family.
messages: Cytoplasm
messages: Interacts with RPT1, RPT2, RPT3, RPT5, RPT6, RPN1 and RPN2. Part of transient complex (BP1) containing HSM3, RPT1, RPT2 and RPT5 formed during the assembly of the 26S proteasome.
messages: Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YKL150W
gene id: 559292:YKL150W
uniprot id: P36060
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: By osmotic stress.
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: Present with 1920 molecules/cell in log phase SD medium.
messages: Simultaneous disruption of CBR1 results in resistance to diphtheria toxin and K.lactis killer toxin.
messages: The outer membrane form may mediate the reduction of outer membrane cytochrome b5 (PubMed:8001120). The soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria (PubMed:8001120). Involved in the reduction of D-erythroascorbyl free radicals (PubMed:11420140). May play a minor role in complementing the function of CBR1 as a DPH3 reductase in the first step of diphthamide biosynthesis and tRNA Wobble base mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine) formation (PubMed:27694803).
messages: There are two isoforms of NADH-cytochrome b5 reductase, a 34 kDa form (p34) and a 32 kDa form (p32). The p34 form becomes firmly anchored to the outer mitochondrial membrane after an incomplete translocation arrest. The p32 form is formed after translocation of the p34 precursor to the inner mitochondrial membrane, where it is processed by mitochondrial inner membrane peptidase (IMP) complex and released to the intermembrane space.

559292:YJR126C
gene id: 559292:YJR126C
uniprot id: P47161
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Involved in vacuolar protein sorting.
messages: Membrane
messages: Present with 112 molecules/cell in log phase SD medium.

559292:YKL166C
gene id: 559292:YKL166C
uniprot id: P05986
names: Activity Regulation
names: Miscellaneous
names: Similarity
messages: Activated by cAMP.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Present with 1590 molecules/cell in log phase SD medium.

559292:YPL145C
gene id: 559292:YPL145C
uniprot id: P35844
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:20008566, PubMed:15173322, PubMed:16136145, PubMed:22162133). Involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum. Specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/Golgi interface, SAC1 may drive PS transport (PubMed:25849868, PubMed:16136145, PubMed:22162133). Displays a similar affinity for PI4P and sterols (PubMed:22162133). Binds sterol and PI4P in a mutually exclusive manner (PubMed:22162133). Involved in ergosterol transport from the plasma membrane (PM) to the ER (PubMed:16585271). Mediates sterol transport from the ER to mitochondria (PubMed:29487131). Involved in the negative regulation of Golgi-derived transport vesicle biogenesis (PubMed:8978672). Plays a role in the positive regulation of vesicular transport of ceramide from the ER to the Golgi, negatively regulating COPII-mediated ER export of cargos (PubMed:24213531).
messages: Present with 32200 molecules/cell in log phase SD medium.
messages: The ArfGAP1 lipid packing sensor (ALPS) motif is a membrane-binding motif that is sensitive to curvature.
messages: The OSBP-related domain (ORD) mediates binding of sterols and phospholipids. It displays an incomplete beta-barrel containing a central hydrophobic tunnel that can accommodate a single lipid molecule with a flexible lid covering the tunnel entrance. The ORD can bind two membranes simultaneously. It has at least two membrane-binding surfaces; one near the mouth of the lipid-binding pocket and a distal site that can bind a second membrane. These structural features correlate with the phosphatidylinositol 4-phosphate (PI(4)P)-coupled lipid transport optimized in closely apposed membranes, such as organelle contact sites. The lipid transfer cycle starts from the association of the LTP with a donor membrane, which accompanies conformational changes that uncover the ligand-binding pocket. The tunnel opening is generally mediated by displacement of the lid covering the binding pocket allowing uptake or release of a lipid molecule. The LTPs extract the lipid from the membrane by providing a hydrophobic environment as well as specific interaction. Dissociation from the donor membrane shifts the conformation to a closed form. Then, the LTPs loaded with a cargo lipid diffuse through the aqueous phase. Lid opening may be induced by the interaction of a hydrophobic side of the lid with the target membranes.

559292:YLR045C
gene id: 559292:YLR045C
uniprot id: P46675
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TOG/XMAP215 family.
messages: Binds to microtubules. Homodimer; each monomer can bind via its TOG domains to two alpha/beta-tubulin heterodimers. Interacts with SPC72. Associates with the NDC80 complex.
messages: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. May play a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body. Stabilizes both cytoplasmic and nuclear microtubules. Promotes mitotic spindle elongation in anaphase. Has microtubule polymerase activity by accelerating microtubule growth and inhibiting catastrophe. The polymerase activity is proposed to involve a tethering mechanism at the microtubule plus end: a curved, longitudinally microtubule lattice-associated tubulin heterodimer (that cannot be incorporated into the microtubule lattice) is bound via one TOG domain while the other TOG domain binds to an unpolymerized tubulin heterodimer leading to lateral association of these tubulin heterodimers; polymerization-induced straightening of the tubulin heterodimer releases the polymerase (PubMed:11309422, PubMed:25172511, PubMed:16567500, PubMed:25097237). Is involved in regulation of kinetochore-microtubule attachments in a tension-dependent manner involving its association with the NDC80 complex; the function may be independent of its microtubule polymerase activity. Can either stabilize or destabilize kinetochore attachments, depending on the level of kinetochore tension and whether the microtubule tip is assembling or disassembling (PubMed:27156448).
messages: Mutations in STU2 suppress a cold-sensitive mutation in TUB2.
messages: Present with 1660 molecules/cell in log phase SD medium.
messages: The TOG (tumor overexpressed gene) domains are composed of six (for the most part non-canonical) HEAT repeats each. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. Two sets of TOG domains may wrap around a single free tubulin heterodimer accompanied by a open-to-closed conformational change of the STU2 homodimer. Both, TOG 1 and TOG 2 bind curved alpha/beta-tubulin with comparable affinity; the two TOG domains bind noncooperatively to two tubulin heterodimers. Free unpolymerized tubulin-binding is predominantly mediated by TOG 1, association with the microtubules plus ends is mediated by TOG 2 in cooperation with a C-terminal basic domain.
messages: The coiled coil domain mediates homodimerization.
messages: kinetochore
messages: spindle
messages: spindle pole body

559292:YLR461W
gene id: 559292:YLR461W
uniprot id: P53427
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Membrane

559292:YGR264C
gene id: 559292:YGR264C
uniprot id: P00958
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of methionine to tRNA(Met) in a two-step reaction: methionine is first activated by ATP to form Met-AMP and then transferred to the acceptor end of tRNA(Met).
messages: Component of a yeast aminoacyl-tRNA synthase (aaRS) complex formed by methionyl-tRNA synthase MES1, glutamyl-tRNA synthase GUS1 and the tRNA aminoacylation cofactor ARC1 in a stoichiometric complex. Interacts (via N-ter) with ARC1 (via N-ter). Can also form a stable binary complex with ARC1 that is functional in terms of aminoacylation. ARC1 increases the affinity for cognate tRNAs due to the presence of a tRNA binding domain in the middle and C-terminal part of ARC1.
messages: Cytoplasm
messages: Present with 85000 molecules/cell in log phase SD medium.

559292:YHR104W
gene id: 559292:YHR104W
uniprot id: P38715
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'De respuesta a estres' means stress response in Spanish.
messages: Aldose reductase with a broad substrate specificity. Reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde under stress conditions. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation (PubMed:11525399). In pentose-fermenting yeasts, aldose reductase catalyzes the reduction of xylose into xylitol. The purified enzyme catalyzes this reaction, but the inability of S.cerevisiae to grow on xylose as sole carbon source indicates that the physiological function is more likely methylglyoxal reduction (Probable) (PubMed:11722921).
messages: Belongs to the aldo/keto reductase family.
messages: By osmotic, ionic, oxidative and heat stress.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Present with 12851 molecules/cell in log phase SD medium.

559292:YCR005C
gene id: 559292:YCR005C
uniprot id: P08679
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Cytoplasm
messages: Expression is repressed in medium containing both glucose and glutamate (PubMed:3023912). Expression is up-regulated by the presence of C2-compounds such as acetate (PubMed:25982115).
messages: Interacts with F-box protein UCC1.
messages: Leads to glutamate auxotrophy and poor growth on rich medium containing lactate, a nonfermentable carbon source, when CIT1 is also deleted.
messages: Peroxisomal citrate synthase involved in the citrate homeostasis (PubMed:3023912, PubMed:25982115). Catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate (PubMed:3023912, PubMed:25982115). Citrate synthase is the rate-limiting enzyme of the tricarboxylic acid (TCA) cycle (Probable).
messages: Peroxisome
messages: Present with 2310 molecules/cell in log phase SD medium.
messages: Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(UCC1), which leads to its degradation by the proteasome (PubMed:25982115). Ubiquitination is prevented by oxaloacetate, suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes CIT2 (PubMed:25982115).

559292:YBR179C
gene id: 559292:YBR179C
uniprot id: P38297
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
messages: Essential transmembrane GTPase, which mediates mitochondrial fusion (PubMed:9685359, PubMed:9786948, PubMed:10562274, PubMed:11266460, PubMed:15297626, PubMed:15760898, PubMed:16624808, PubMed:19812251, PubMed:21385840, PubMed:21502136, PubMed:23317502, PubMed:27253069). Fusion proceeds through several steps; first mitochondria are tethered together, then brought into close contact, followed by the formation of a docking ring around contact areas, and finally membrane fusion (PubMed:27253069). Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondrial morphology, which is balanced between fusion and fission, mediated by FZO1 and DNM1, respectively (PubMed:10562274). Functions antagonistically with DNM1 (PubMed:10562274). Probably acts by forming membrane contact sites that mediate mitochondrial membrane fusion (PubMed:27253069). Mitochondrial docking and fusion requires GTP hydrolysis (PubMed:15297626, PubMed:19812251, PubMed:27253069). Mitochondrial fusion promotes also increased lifespan.
messages: Homodimer (PubMed:16624808, PubMed:21385840, PubMed:19812251). Dimerization depends on GTP binding (PubMed:16624808, PubMed:21385840, PubMed:19812251). Component of a large multiprotein complex of 800 kDa (PubMed:9685359). Binds the cytoplasmic domain of UGO1 which binds MGM1 through its intermembrane space domain (PubMed:15087460, PubMed:12808034). Interacts with MDM30 (PubMed:21385840, PubMed:21502136, PubMed:16735578). Interacts with UBP2 and UBP12 (PubMed:23317502). Interacts (when ubiquitinated) with DOA1; the interaction recruits FZO1 to CDC48 and promotes FZO1 proteasomal degradation (PubMed:27044889).
messages: Mitochondrion outer membrane
messages: Present with 1000 molecules/cell in log phase SD medium.
messages: The GTPase domain may regulate the interaction with UGO1 since FZO1 lacking the GTPase domain binds 5-fold higher amount of UGO1 than full-length FZO1. The coiled-coil heptad repeat domains HRN, HR1 and HR2 are required for the oligomerization and function in mitochondrial fusion.
messages: Ubiquitinated at Lys-398 and Lys-464 (PubMed:19812251, PubMed:23317502, PubMed:27044889). MDM30 and UGO1 are involved in ubiquitination (PubMed:18353967, PubMed:21385840, PubMed:21502136). Deubiquitinated by UBP2 and UBP12 (PubMed:23317502). UBP2 and UBP12 recognize distinct ubiquitin chains on FZO1 that have opposing effects on mitochondrial fusion (PubMed:23317502). UBP2 removes ubiquitin chains that initiate proteolysis of FZO1 and inhibit fusion (PubMed:23317502). UBP12 recognizes ubiquitin chains that stabilize FZO1 and promote mitochondrial fusion. UBP12 deubiquitylates FZO1 only after oligomerization (PubMed:23317502).

559292:YOR276W
gene id: 559292:YOR276W
uniprot id: P12962
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA. Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631. Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation.
messages: Belongs to the CAF20 family.
messages: Cytoplasm
messages: Interacts with TIF45.
messages: Phosphorylated by casein kinase II complex (CK2).
messages: Present with 26900 molecules/cell in log phase SD medium.

559292:YLL014W
gene id: 559292:YLL014W
uniprot id: Q12431
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).

559292:YIR021W-A
gene id: 559292:YIR021W-A
uniprot id: Q3E739
names: Subcellular Location Annotation
messages: Membrane

559292:YDR453C
gene id: 559292:YDR453C
uniprot id: Q04120
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: By peroxides.
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation.
messages: Present with 4820 molecules/cell in log phase SD medium.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (PubMed:10681558, PubMed:11741925, PubMed:15210711). Can act alternatively as peroxidase and molecular chaperone. Oxidative stress and heat shock exposure cause a reversible shift of the protein structure from low MW species to high MW complexes, triggering a peroxidase-to-chaperone functional switch. The chaperone function of the protein enhances resistance to heat shock (PubMed:15163410).

559292:YER095W
gene id: 559292:YER095W
uniprot id: P25454
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RecA family. RAD51 subfamily.
messages: By X-rays.
messages: Chromosome
messages: Nucleus
messages: Part of a repair/recombination complex that includes RAD51, RAD52 and RAD54. Interacts with HED1, RDH54 and SAW1.
messages: Present with 6960 molecules/cell in log phase SD medium.
messages: RAD51 is cell cycle regulated, peaking around the G1-to-S transition.
messages: Required both for recombination and for the repair of DNA damage caused by X-rays. Its function may be modulated by interaction with other repair proteins. RAD52 interacts directly with RAD51, via its C-terminus. Forms a nucleoprotein filament with DNA as an early intermediate in recombination.

559292:YJL108C
gene id: 559292:YJL108C
uniprot id: P42946
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane
messages: This is a truncated version of a ThrE family protein. Strain S288c has a frameshift in position 382, which disrupts the gene coding for this protein and produces two ORFs YJL107C and YJL108C. A contiguous sequence for a S.cerevisiae ThrE family protein can be found in strain YJM789 (AC A6ZQL9).

559292:YAL026C
gene id: 559292:YAL026C
uniprot id: P39524
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Interacts with CDC50.
messages: Present with 606 molecules/cell in log phase SD medium.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly.
messages: trans-Golgi network membrane

559292:YNL008C
gene id: 559292:YNL008C
uniprot id: P53983
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the Asi complex, which contains ASI1, ASI2 and ASI3 (PubMed:25236469). Interacts directly with ASI1 (PubMed:17085444).
messages: Nucleus inner membrane
messages: Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation (PubMed:25236469). Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444). Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748).

559292:YOR140W
gene id: 559292:YOR140W
uniprot id: P20134
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: In the N-terminal section; belongs to the HSF family.
messages: Involved in cell surface assembly and regulation of the gene related to flocculation (asexual cell aggregation). Mutations in SFL1 causes constitutive cell aggregation.
messages: Nucleus
messages: Present with 1040 molecules/cell in log phase SD medium.

559292:YNR023W
gene id: 559292:YNR023W
uniprot id: P53628
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SWP82. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Nucleus
messages: To yeast RSC6.

559292:YNL329C
gene id: 559292:YNL329C
uniprot id: P33760
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AAA-cassette D1 is required for interaction with PEX1. ATP-binding in AAA-cassette D1 is required for attachment to PEX15. ATP-binding and hydrolysis in AAA-cassette D2 is required for release from PEX15 and proper function in PEX5 dislocation.
messages: Belongs to the AAA ATPase family.
messages: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:15634331, PubMed:16007078, PubMed:16911527, PubMed:26170309, PubMed:26066397, PubMed:29321502). Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:26170309, PubMed:26066397, PubMed:29321502). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29321502).
messages: Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers (PubMed:15634331, PubMed:16007078, PubMed:26170309, PubMed:26066397, PubMed:29321502). Interacts with PEX15; anchors PEX1-PEX6 heterooligomers to the peroxisomal membrane and mediates their association with the peroxisomal importomer (PubMed:12808025). Interacts with UBP15 (PubMed:21665945).
messages: Peroxisome membrane
messages: Present with 1630 molecules/cell in log phase SD medium.
messages: cytosol

559292:YKL039W
gene id: 559292:YKL039W
uniprot id: P32857
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Early endosome membrane
messages: Golgi apparatus membrane

559292:YML045W
gene id: 559292:YML045W
uniprot id: Q04711
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YML045W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YIL054W
gene id: 559292:YIL054W
uniprot id: P40524
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 521 molecules/cell in log phase SD medium.

559292:YPL003W
gene id: 559292:YPL003W
uniprot id: Q12059
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Heterodimer of UBA3 and ULA1. The complex binds NEDD8 and UBC12 (By similarity).
messages: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme. E1 activates NEDD8/RUB1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBC12.

559292:YGR037C
gene id: 559292:YGR037C
uniprot id: P31787
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
messages: Present with 8500 molecules/cell in log phase SD medium.

559292:YDR125C
gene id: 559292:YDR125C
uniprot id: Q04623
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
messages: May be involved in cell wall organization and biogenesis.
messages: Mitochondrion
messages: Present with 143 molecules/cell in log phase SD medium.
messages: The HXXXXD motif is essential for acyltransferase activity.

559292:YOR250C
gene id: 559292:YOR250C
uniprot id: Q08685
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Causes defective 3'-end formation and transcriptional read-through.
messages: Component of the cleavage factor IA (CF IA) complex, which is a heterohexameric complex with 2:2:1:1 stoichiometry of RNA14, RNA15, PCF11 and CLP1. It contains 2 copies of an RNA14-RNA15 dimer and 1 copy of CLP1-PCF11. The complex interacts with the cleavage factor HRB1/CF IB to form the cleavage factor I (CF I) complex, and binds to RNA. Interacts directly with PCF11. Interacts with the CPF components CFT1, PTA1, PFS2, YSH1 and SSU72.
messages: Component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation. Associates with HRB1/CF IB to form the cleavage factor I (CF I) complex. CF I is required for correct positioning of a larger protein complex, the cleavage and polyadenylation factor (CPF) complex, which contains the catalytic subunits executing mRNA cleavage and polyadenylation. CLP1 mediates interactions between CF IA and CPF factors. CLP1 is also involved in maintaining the CF IA interaction with the C-terminal domain of RNA Pol II largest subunit via PCF11, which links pre-mRNA 3'-end processing to transcription termination.
messages: May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.
messages: Nucleus

559292:YKL009W
gene id: 559292:YKL009W
uniprot id: P33201
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: Present with 18200 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YKL138C
gene id: 559292:YKL138C
uniprot id: P14063
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL60 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 2100 molecules/cell in log phase SD medium.

559292:YPL211W
gene id: 559292:YPL211W
uniprot id: Q08962
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Cytoplasm
messages: Interacts with NOP8 and RRP43. Interacts with pre-ribosome complex. May bind to RNA.
messages: Present with 5170 molecules/cell in log phase SD medium.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

559292:YDR128W
gene id: 559292:YDR128W
uniprot id: Q03897
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR59 family.
messages: Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.
messages: Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in telomere capping.
messages: Present with 556 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YDR280W
gene id: 559292:YDR280W
uniprot id: Q05636
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:17173052 and PubMed:17174896, only DIS3/RRP44 subunit of the exosome core has exonuclease activity.
messages: Belongs to the RNase PH family.
messages: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure. Interacts with LRP1.
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP45 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.
messages: Present with 4800 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YNL318C
gene id: 559292:YNL318C
uniprot id: P42833
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Probable glucose transporter.

559292:YPL017C
gene id: 559292:YPL017C
uniprot id: Q02733
names: Caution
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Although strongly related to the LPD1 dihydrolipoyl dehydrogenase, it lacks the redox-active disulfide bond suggesting that it has no dehydrogenase activity.
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm
messages: Present with 6400 molecules/cell in log phase SD medium.

559292:YNL110C
gene id: 559292:YNL110C
uniprot id: P53927
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1.
messages: Cytoplasm
messages: Essential gene. Abrupt growth arrest prior to substantial depletion of ribosomal subunits. Fails to synthesize the 25S and 5.8S rRNA components of the 60S ribosomal subunit, and exonucleolytic 5' processing of 5.8S rRNA is strongly inhibited. Arrests at cytokinesis and fails to assemble a contractile actin ring at the bud neck.
messages: Involved in the biogenesis of the 60S ribosomal subunit. Required for pre-rRNA processing and cytokinesis. Associates with the precursors of the 25S and 5.8S rRNAs.
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YML085C
gene id: 559292:YML085C
uniprot id: P09733
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:11739794). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Present with 5590 molecules/cell in log phase SD medium.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:11739794). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

559292:YKL096W
gene id: 559292:YKL096W
uniprot id: P28319
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall.
messages: Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from a specific glutamine within the PIR1/2/3 repeat, and hydroxyl groups of glucoses of beta-1,3-glucan chains (By similarity). The alkali-sensitive linkage is induced by low pH.
messages: Extensively O-glycosylated.
messages: Membrane
messages: Positively regulated by cell integrity signaling through MPK1 in response to cell wall perturbation. Induction is dependent on transcription factor RLM1. Down-regulated during anaerobic growth. Up-regulated by low pH.
messages: Present with 67000 wall-bound molecules/cell in log phase YPD medium.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The strains CLIB 410 and CLIB 630 haplotype Ha2, contain large deletions that remove most of the protein.
messages: cell wall

559292:YOR052C
gene id: 559292:YOR052C
uniprot id: Q08422
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: May have a role in protecting cells from metalloid-induced proteotoxicity.
messages: Nucleus
messages: Present with 9520 molecules/cell in log phase SD medium.

559292:YBL009W
gene id: 559292:YBL009W
uniprot id: P32789
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
messages: Absent in G1-arrested cells and accumulates in G2-M.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
messages: Periodically phosphorylated during the cell cycle with a phosphorylation peak during mitosis and hyperphosphorylated after DNA damage.
messages: Serine/threonine haspin-like protein kinase involved in cell cycle regulation.
messages: The KEN and D (destructive) boxes are required for the cell cycle-controlled ALK2 degradation by the anaphase promoting complex (APC) pathway.
messages: The protein kinase domain is predicted to be catalytically inactive. However, weak kinase activity was experimentally demonstrated.

559292:YIL009C-A
gene id: 559292:YIL009C-A
uniprot id: Q03096
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EST3 family.
messages: Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.
messages: Homodimer. Component of the telomerase complex composed of EST1, EST2, EST3 and the RNA component TLC1. Interacts with the telomerase RNA component TLC1 in presence of EST2.
messages: Nucleus
messages: Produced by ribosomal frameshifting between codon Leu-92 and Val-93.
messages: Produced from conventional translation of the YIL009C-A ORF. There is no apparent role for isoform 2 in the cell.
messages: telomere

559292:YPL094C
gene id: 559292:YPL094C
uniprot id: P21825
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. In an initial step, the signal sequence seems to bind simultaneously to SEC61 and SEC62. SEC62 and SEC63 are required for interactions between SEC61 and translocating polypeptides. SEC62 may affect SEC1-polypeptide interactions by increasing the affinity of targeting pathways for SEC61 and/or by modifying SEC61 to allow more efficient polypeptide interaction. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC62 is essential for cell growth.
messages: Belongs to the SEC62 family.
messages: Component of the heterotetrameric Sec62/63complex composed of SEC62, SEC63, SEC71 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex.
messages: Endoplasmic reticulum membrane
messages: Present with 16500 molecules/cell in log phase SD medium.

559292:YKL069W
gene id: 559292:YKL069W
uniprot id: P36088
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the free Met sulfoxide reductase family.
messages: Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Does not act on S-enantiomer of free methionine sulfoxide or R-enantiomer of dabsylated methionine sulfoxide. Involved in protection against oxidative stress.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2610 molecules/cell in log phase SD medium.
messages: Single deletion of fRMsr has complete growth inhibition on methionine-R-sulfoxide medium and fRMsr and MXR1 double deletion completely blocks the growth on both methionine-R-sulfoxide and methionine-S-sulfoxide medium. FRMsr and MXR2 double deletion has no effect on growth on methionine-S-sulfoxide medium. Single mutant or any of the double mutants show no growth defects in methionine medium, even the fRMsr, MXR1 and MXR2 triple deletion mutant is viable and grows similarly to wild-type. Single deletion of fRMsr has an increased sensitivity to oxidative stress and a decreased life span of 18% compared to wild-type. FRMsr and MXR1, as well as fRMsr and MXR2 double mutants, and fRMsr, MXR1 and MXR2 triple mutant show 20% reduction in life span compared with wild-type cells.

559292:YDR272W
gene id: 559292:YDR272W
uniprot id: Q05584
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Present with 13700 molecules/cell in log phase SD medium.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

559292:YHR112C
gene id: 559292:YHR112C
uniprot id: P38716
names: Miscellaneous
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YDR430C
gene id: 559292:YDR430C
uniprot id: P32898
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by nucleotides, including ATP, GTP, CTP, UTP, and ADP (PubMed:35997162). Activated by copper, manganese, calcium and magnesium ions; copper and manganese restore activity following inactivation by EDTA (ethylenediaminetetraacetic acid) (PubMed:35997162). Inhibited by metal chelators including EDTA, EGTA (ethylene glycol bis(2-aminoethyl)tetraacetic acid), and 1,10-phenanthroline (PubMed:35997162). Inhibited by copper, zinc, and iron ions (PubMed:35997162). Also inhibited by dithiothreitol p-mercuribenzenesulfonic acid, N-ethylmaleimide, protoporphyrin, hemin, protamine and triarginine (PubMed:35997162).
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Decreases processing of mitochondrial precursor proteins (PubMed:25176146). Impairs mitochondrial function; increases levels of reactive oxygen species (ROS) in cells, impairs oxygen consumption and decreases the membrane potential (PubMed:25176146). Simultaneous disruption of the mitochondrial-processing peptidase subunit MAS1 or the mitochondrial peptidase OCT1 results in synthetic lethality in respiratory conditions (PubMed:25176146). Decreases processing and activity of SOD2 (PubMed:35997162).
messages: Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (PubMed:15772085, PubMed:25176146). Preferentially cleaves the N-terminal side of paired basic amino acid residues (PubMed:35997162). Also degrades other unstructured peptides (PubMed:25176146). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (PubMed:35997162).
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.
messages: Present with 6140 molecules/cell in log phase SD medium.

559292:YNL103W
gene id: 559292:YNL103W
uniprot id: P32389
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Interacts with MET30. Tethered to DNA through two alternate complexes associating MET4 with MET28 and either MET31 or MET32. Interacts with MET28 and CBF1 through its leucine zipper to form a heteromeric complex.
messages: Nucleus
messages: Positive trans-acting factor capable of stimulating the transcription of the MET genes from the methionine biosynthetic pathway. MET4, MET28 and CBF1 are required for full induction of MET25 and MET16 gene transcription. MET4 controls as well the derepression of MET6. Required for the transcription of genes necessary for sulfur amino acid biosynthesis. Involved in the transcription activation of MET28 and MET30. Required for MET3 gene expression via assembly of the MET4-MET28-MET31 and MET4-MET28-MET32 complexes. Involved in response to cadmium and arsenic. Cadmium-activated MET4 also induces glutathione biosynthesis.
messages: Present with 1300 molecules/cell in log phase SD medium.
messages: Regulated by the general amino acid control.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activation function is inhibited by the elevation of intracellular S-adenosylmethionine (AdoMet), but is activated by cadmium and arsenic which leads to phosphorylation and prevents ubiquitination. Inactivation by oxidative stress induced by hydrogen peroxide promotes ubiquitination.

559292:YDL198C
gene id: 559292:YDL198C
uniprot id: P38988
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial GTP/GDP transporter required for GTP uptake and GDP exit from mitochondria. Involved in mitochondrial iron transport and essential for mitochondrial genome maintenance.
messages: Mitochondrion inner membrane

559292:YHR192W
gene id: 559292:YHR192W
uniprot id: P38878
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Interacts with RTN1; this interaction is negatively regulated by SEY1. Interacts with SEY1 and YOP1.
messages: Plays a role in tubular endoplasmic reticulum network formation and maintenance. Works in conjunction with the ER shaping proteins (reticulons RTN1 and RTN2, YOP1), and in antagonism to SEY1 to maintain the network in a dynamic equilibrium. May counterbalance SEY1-directed polygon formation by promoting polygon loss through ring closure.
messages: Present with 3390 molecules/cell in log phase SD medium.

559292:YNL175C
gene id: 559292:YNL175C
uniprot id: P53883
names: Miscellaneous
names: Subcellular Location Annotation
messages: Present with 3830 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YOR125C
gene id: 559292:YOR125C
uniprot id: P41735
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (PubMed:16624818, PubMed:8621692, PubMed:9452453, PubMed:23940037). Has also a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides (PubMed:16624818).
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Dephosphorylation by PTC7 leads to activation.
messages: Mitochondrion inner membrane
messages: Phosphorylated (PubMed:23940037). Dephosphorylated by PTC7; dephosphorylation is essential for enzyme activation (PubMed:23940037).
messages: Was originally thought to be involved in carbon catabolite repression (PubMed:8557031). It has later been demonstrated that the catabolite-regulation defect in COQ7 mutants was a secondary effect of the respiration deficiency in ubiquinone-deficient mutants and could be rescued by the addition of exogenous ubiquinone (PubMed:9452453).

559292:YKR074W
gene id: 559292:YKR074W
uniprot id: P36154
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0538 family.
messages: Cytoplasm
messages: May be involved in mitochondrial organization and biogenesis.
messages: Present with 1230 molecules/cell in log phase SD medium.

559292:YMR295C
gene id: 559292:YMR295C
uniprot id: Q03559
names: Miscellaneous
names: Similarity
messages: Present with 10800 molecules/cell in log phase SD medium.
messages: To yeast YGR273c.

559292:YDR034C-D
gene id: 559292:YDR034C-D
uniprot id: Q12472
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YDR034C-C ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YBR112C
gene id: 559292:YBR112C
uniprot id: P14922
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
messages: Associates with TUP1 to form the CYC8-TUP1 (or TUP1-SSN6) corepressor complex that is composed of 4 copies of TUP1 and one copy of CYC8. Interacts with MATALPHA2, CTI6, MIG1, TUP1, SUT1, RFX1, PGD1, HOS1, HOS2 and RPD3.
messages: Belongs to the CYC8/SSN6 family.
messages: Nucleus
messages: Present with 3890 molecules/cell in log phase SD medium.
messages: The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
messages: [OCT+] is the prion form of CYC8. [OCT+] is the result of a conformational change of the cellular CYC8 protein that becomes self-propagating and infectious. [OCT+]-aggregates sequester soluble CYC8, resulting in increased levels of iso-2-cytochrome c, defects in sporulation and mating, higher levels of invertase derepression and increased flocculation, reminiscent of a partial loss of function of the CYC8-TUP1 corepressor complex. [OCT+] can be cured by GdnHCl and by inactivation of the molecular chaperone HSP104, which is required for [OCT+] propagation. It is speculated that prion properties of transcription factors may generate an optimized phenotypic heterogeneity that buffers yeast populations against diverse environmental insults.

559292:YHR005C
gene id: 559292:YHR005C
uniprot id: P08539
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that mediates mating pheromone signal transduction. Binding of alpha-factor or a-factor to its cognate transmembrane receptor STE2 and STE3, respectively, allows the receptor to serve as a guanine nucleotide exchange factor (GEF) on GPA1. The exchange of GDP for GTP on the G protein alpha subunit alters its interaction with the G protein beta subunit STE4, leading to dissociation of the G protein beta-gamma dimer STE4-STE18. The dissociated subunits activate downstream effectors to activate the mating response pathway and induce changes necessary to produce mating-competent cells. STE4-STE18 activate the downstream pheromone signaling MAP kinase cascade leading to expression of mating-specific genes, inducing cell cycle arrest in G1, promoting polarized cell growth to form mating projections (shmoos), and establishing the changes in plasma membrane, cell wall and nuclear envelope to permit cell-cell fusion (plasmogamy) and fusion of the two haploid nuclei (karyogamy). GPA1 transmits a signal that requires direct binding to the effector enzyme PI3K located at the endosome, promoting increased PI3 production. The intrinsic GTPase activity of GPA1 determines the duration of signaling, and is dramatically accelerated by the RGS protein SST2. In unstimulated cells, GDP-bound GPA1 sequesters the G protein beta-gamma subunit STE4-STE18, preventing it from activating the downstream effectors. Also down-regulates the signal by inhibiting the pheromone-induced accumulation of FUS3 in the nucleus.
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by the G protein coupled receptors (GPCRs) STE2 and STE3, which serve as guanine nucleotide-exchange factors (GEFs), and inactivated by SST2, probably acting as a GTPase-activating protein (GAP).
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: Cell membrane
messages: Contains an 'insertion' sequence of 109 residues which is not present in other G-protein alpha chains.
messages: Endosome membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. In its GDP-bound form, binds to the G protein beta-gamma dimer STE4-STE18. Directly interacts with the beta subunit STE4. Probably forms preactivation complexes with unligated receptors STE2 and STE3. Interacts with FUS3. Pheromone-induced activation of GPA1 increases its association with FUS3. Interacts with SCP160. SCP160 binds specifically to the GTP-bound form of GPA1. Interacts with the phoshpatidylinositol 3-kinase (PI3K) subunits VPS15 and VPS34 at the endosome. The GTP-bound form of GPA1 binds directly and selectively to the catalytic subunit VPS34, while the GDP-bound form binds to VPS15, which appears to function as an alternative G protein beta subunit for GPA1. Interacts with regulators of G protein signaling (RGS) proteins MDM1, RAX1, RGS2 and SST2, but SST2 alone binds preferentially to the transition state conformation of GPA1, indicating that it acts as a GAP for this G protein.
messages: Monoubiquitination targets the protein for degradation to the vacuole, and polyubiquitination tags the protein for degradation by the proteasome. This may be an additional signaling regulation mechanism.
messages: N-myristoylation by NMT1 is pheromone-stimulated and required for palmitoylation of Cys-3. This lipid modification anchors the protein to membranes. Depalmitoylated by YLR118C/APT1.
messages: Present with 9920 molecules/cell in log phase SD medium.

559292:YMR079W
gene id: 559292:YMR079W
uniprot id: P24280
names: Activity Regulation
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Present with 84300 molecules/cell in log phase SD medium.
messages: Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes in vitro. Essential for viability and secretion (PubMed:2466847, PubMed:2215682). Exchanges its bound phospholipid with phospholipid monomers that reside in membrane bilayers (PubMed:16997918). Regulates specific trans-Golgi export pathways, like transport from endosomes to the trans-Golgi or transport from the plasma membrane to the vacuole at the level of the endosome (PubMed:19129178). Increased membrane curvature and lipid unsaturation levels at the trans-Golgi membrane promotes membrane binding and phospholipid transfer of SEC14. Thus, SEC14 may act at the trans-Golgi membrane to exchange lipids and promote vesicle formation (PubMed:32828847). The phosphatidylcholine-bound form of SEC14 represses the CDP-choline pathway activity by inhibiting CCTase, the rate-determining enzyme of the CDP-choline pathway (PubMed:7816798). PI binding/transfer is dispensable for function in vivo (PubMed:10488334). Required for trafficking and localization of lipid raft proteins to the plasma membrane (PubMed:23383173).
messages: The inhibitor activity of SEC14 is controlled by whether PI or PC is bound to SEC14. The pPC-bound form of SEC14 is an inhibitor, while the PI-bound form is not. The phospholipid binding/exchange activity of SEC14 represents a mechanism by which the regulatory activity of SEC14 is itself controlled.

559292:YCL036W
gene id: 559292:YCL036W
uniprot id: P25370
names: Function
messages: High-copy suppressor of DBP5 mutation.

559292:YDR319C
gene id: 559292:YDR319C
uniprot id: Q06676
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Yeast FIT2A/YFT2 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (PubMed:26504167) (By similarity). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (PubMed:29526591) (By similarity). May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Involved in phospholipid biosynthesis (PubMed:29417057) (By similarity).
messages: Vacuole

559292:YBR191W
gene id: 559292:YBR191W
uniprot id: Q02753
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL21 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: There are 2 genes for eL21 in yeast.

559292:YAR019C
gene id: 559292:YAR019C
uniprot id: P27636
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Bud neck
messages: Constitutively expressed.
messages: Homodimer. Interacts with TEM1.
messages: It is uncertain whether Met-1 or Met-4 is the initiator.
messages: Kinase activity is inhibited by phosphorylation and activated by dephosphorylation by CDC14.
messages: Phosphorylation by CDK1 reduces the binding to the mother spindle pole body. The extent of phosphorylation gradually increases during cell-cycle progression until some point during late anaphase/telophase when it is rapidly dephosphorylated by CDC14. Phosphorylation inhibits kinase activity and dephosphorylation by CDC14 activates CDC15.
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Protein kinase of the mitotic exit network (MEN) essential for late nuclear division in the mitotic cycle. Promotes mitotic exit by phosphorylating DBF2 and directly switching on DBF2 kinase activity. Involved in the localization of DBF2 and DBF20 to the neck which is necessary to undergo cytokinesis. Plays a role in segregation of chromosomes during recovery from spindle checkpoint activation. Required for spindle pole localization of CDK1 and inactivation of CDC2 kinase activity at the end of mitosis. Required for spindle disassembly after meiosis II and plays a role in spore morphogenesis.
messages: The region between residues 360 and 702 is essential for function and is required for self-association and for binding to spindle pole bodies.
messages: The region between residues 751 and 974 is an auto-inhibitory domain which inhibits MEN signaling.
messages: spindle pole

559292:YDR166C
gene id: 559292:YDR166C
uniprot id: P89102
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Present with 3400 molecules/cell in log phase SD medium.
messages: The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

559292:YIL098C
gene id: 559292:YIL098C
uniprot id: P40491
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMC1 family.
messages: Mitochondrion
messages: Needed for the assembly of the mitochondrial F1-F0 complex at high temperature.
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YDR195W
gene id: 559292:YDR195W
uniprot id: P42073
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with FIR1. Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.
messages: Nucleus
messages: Present with 7450 molecules/cell in log phase SD medium.
messages: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Negative regulator of poly(A) synthesis. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. REF2 is required for 3'-end formation of snoRNAs.

559292:YIL162W
gene id: 559292:YIL162W
uniprot id: P00724
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Isoform Secreted is glycosylated. Isoform Intracellular is not glycosylated.
messages: Present with 1780 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-21 of isoform Secreted.
messages: Secreted

559292:YNL159C
gene id: 559292:YNL159C
uniprot id: P53895
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the Asi complex, which contains ASI1, ASI2 and ASI3.
messages: Not glycosylated.
messages: Nucleus inner membrane
messages: Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation (PubMed:25236469). Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444). Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748).

559292:YMR124W
gene id: 559292:YMR124W
uniprot id: P39523
names: Miscellaneous
messages: Present with 166 molecules/cell in log phase SD medium.

559292:YOR025W
gene id: 559292:YOR025W
uniprot id: P53687
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent histone deacetylase, which contributes together with HST4 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.
messages: Nucleus
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YKR063C
gene id: 559292:YKR063C
uniprot id: P36146
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAS1 family.
messages: Mitochondrion
messages: Nucleus
messages: Present with 647 molecules/cell in log phase SD medium.
messages: Regulates cell surface growth, bud formation and morphogenesis. May act indirectly by regulating factor(s) involved in these processes.

559292:YDR114C
gene id: 559292:YDR114C
uniprot id: Q04597
names: Function
messages: May be involved in growth at elevated pH and presence of calcium.

559292:YGR156W
gene id: 559292:YGR156W
uniprot id: P39927
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. PTI1 is required for 3'-end formation of snoRNAs.
messages: Nucleus
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YNL143C
gene id: 559292:YNL143C
uniprot id: P53908
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YDL006W
gene id: 559292:YDL006W
uniprot id: P35182
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit. Manganese is about 20 times more efficient than magnesium.
messages: Interacts with NBP2 and PBS2.
messages: It has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. It is essential for growth or germination at 37 degrees Celsius. May have a role in the heat shock response. Involved in tRNA splicing and cell separation.
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:YPR141C
gene id: 559292:YPR141C
uniprot id: P17119
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
messages: By alpha factor.
messages: Essential for yeast nuclear fusion during mating. KAR3 is a bifunctional protein having a kinesin-like motor domain joined to a distinct microtubule binding domain. It may mediate microtubule sliding during nuclear fusion and possibly mitosis. May interact with spindle microtubules to produce an inwardly directed force acting upon the poles. KAR3 function antagonizes CIP8 and KIP1 outward force action. KAR3 motor activity is directed toward the microtubule's minus end.
messages: Interacts with CIK1 and VIK1.
messages: KAR3 contains two globular domains separated by an alpha-helical coiled coil. The N-terminal portion of KAR3 contains a microtubule association domain distinct from the kinesin-like C-terminal domain.
messages: Nucleus
messages: Present with 3250 molecules/cell in log phase SD medium.
messages: cytoskeleton
messages: spindle pole body

559292:YPL273W
gene id: 559292:YPL273W
uniprot id: Q08985
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S-methylmethionine (SMM) to methionine.
messages: Nucleus
messages: Present with 60300 molecules/cell in log phase SD medium.
messages: Up-regulated in response to high extracellular methionine.

559292:YGR072W
gene id: 559292:YGR072W
uniprot id: P48412
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RENT3 family.
messages: Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
messages: Nucleus
messages: Present with 1250 molecules/cell in log phase SD medium.

559292:YGR010W
gene id: 559292:YGR010W
uniprot id: P53204
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic NMN adenylyltransferase family.
messages: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:12597897). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis (By similarity). Predominantly acts in the salvage pathways via NMN (PubMed:11884393).
messages: Divalent metal cation.
messages: Expression is slightly induced in late log phase.
messages: Nucleus
messages: Present with 1430 molecules/cell in log phase SD medium.

559292:YCR066W
gene id: 559292:YCR066W
uniprot id: P10862
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD18 family.
messages: E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR. The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
messages: Homodimer. Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity. The UBC2-RAD18 complex interacts itself with the UBC13-MMS2 ubiquitin ligase complex through direct interactions of both RAD18 and UBC13 with RAD5. Interacts also with UBC9. Binds single strand DNA.
messages: Nucleus
messages: Present with 206 molecules/cell in log phase SD medium.

559292:YDR097C
gene id: 559292:YDR097C
uniprot id: Q03834
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. MSH6 provides substrate-binding and substrate specificity to the complex. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair base-base and single insertion-deletion mismatches that occur during replication, but can also repair longer insertion-deletion loops (IDLs), although with decreasing efficiency as the size of the extrahelical loop increases. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis by the MutS alpha complex is crucial for MMR. Both subunits bind ATP, but with differing affinities, and their ATPase kinetics are also very different. MSH6 binds and hydrolyzes ATP rapidly, whereas MSH2 catalyzes ATP at a substantially slower rate. Binding to a mismatched base pair suppresses MSH6-catalyzed ATP hydrolysis, but not the activity of MSH2. ATP binding to both subunits is necessary to trigger a change in MutS alpha interaction with mismatched DNA, converting MutS alpha into a sliding clamp capable of hydrolysis-independent movement along DNA, and also facilitates formation of ternary complexes containing MutS and MutL proteins and the mismatch. May also be involved in resolution of recombination intermediates.
messages: Heterodimer consisting of MSH2-MSH6 (MutS alpha). Forms a ternary complex with MutL alpha (MLH1-PMS1). MutS alpha interacts with proliferating cell nuclear antigen (PCNA/POL30). This interaction is disrupted upon binding of MutS alpha to mismatch DNA.
messages: Inhibited by Cd(2+).
messages: Nucleus
messages: Present with 5330 molecules/cell in log phase SD medium.
messages: The PIP box serves as a PCNA(POL30)-recognition and -binding motif.

559292:YGR109W-B
gene id: 559292:YGR109W-B
uniprot id: Q99315
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the genomic RNA-nucleocapsid complex.
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs.
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein.
messages: Nucleocapsid protein p11 (NC) forms the nucleocore that coats the retro-elements dimeric RNA. Binds these RNAs through its zinc fingers (By similarity). Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription.
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Ala-285 and Val-286 of the YGR109W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty3 retrotransposons belong to the gypsy-like elements (metaviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The protease is a homodimer, whose active site consists of two apposed aspartic acid residues.

559292:YLR158C
gene id: 559292:YLR158C
uniprot id: P0CX77
uniprot id: P0CX78
uniprot id: P0CX79
uniprot id: P0CZ17
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asparaginase 1 family.
messages: Periplasm
messages: Secreted
messages: Subject to nitrogen catabolite repression (NCR). Not found in cells grown on rich nitrogen sources like ammonia, glutamine or glutamate, but is found in cells that have been subjected to nitrogen starvation or have been grown on a poor nitrogen source such as proline.
messages: There are 4 copies for L-asparaginase 2 in yeast. The 4 identical copies ASP3-1, ASP3-2, ASP3-3 and ASP3-4 are arranged in tandem repeats located near a ribosomal DNA cluster.
messages: Yeast contains 2 L-asparaginase isoenzymes: cytoplasmic L-asparaginase I, and cell wall L-asparaginase II.

559292:YDL119C
gene id: 559292:YDL119C
uniprot id: Q07534
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 1550 molecules/cell in log phase SD medium.
messages: Yeasts grow well on the fermentable carbon source dextrose, but only poorly aerobically on glycerol, indicating a defect in respiration. Furthermore, the deletion strain is unable to reduce sodium nitroprusside, indicating that the defect is likely in heme biosynthesis. Nitroprusside reduction can be rescued by supplementation of the medium with either glycine or 5-aminolevulinate (ALA) (PubMed:19412178). In combination with a disruption of MCX1, abrogates mitochondrial respiration (PubMed:25957689).

559292:YLR424W
gene id: 559292:YLR424W
uniprot id: Q06411
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NTR complex (NTC-related complex), composed of NTR1, NTR2 and PRP43. Interacts with CLF1 and NTR2. Interacts with PRP43 and PRP45.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.
messages: Nucleus
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YOL127W
gene id: 559292:YOL127W
uniprot id: P04456
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL23 is associated with the polypeptide exit tunnel (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL23 is a major component of the universal docking site for these factors at the polypeptide exit tunnel.
messages: Cytoplasm

559292:YOL072W
gene id: 559292:YOL072W
uniprot id: Q08231
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. THP1 binds to RNA in vitro.
messages: Heterodimer with THP1. The SAC3-THP1 complex interacts with CDC31 and SUS1, and with the mRNA export factor MEX67-MTR2, the TREX complex component SUB2, and the nucleoporin NUP1.
messages: Nucleus envelope
messages: Present with 1140 molecules/cell in log phase SD medium.

559292:YGL063W
gene id: 559292:YGL063W
uniprot id: P53167
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Mitochondrial-specific pseudouridine synthase catalyzing the formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of mitochondrial transfer RNAs.
messages: Mitochondrion

559292:YEL020C
gene id: 559292:YEL020C
uniprot id: P39994
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.
messages: Cytoplasm
messages: Does not affect growth on oleate.
messages: Peroxisomal targeting signal 1 (PTS1) is a tripeptide located at the C-terminus of more than 95% of all peroxisomal matrix proteins. The prototypical PTS1 is the terminal tripeptide SKL (serine-lysine-leucine) but the consensus of PTS1 is defined as [S/A/H/C/E/P/Q/V] [K/R/H/Q] [L/F]. However, this description of the PTS1 consensus must probably be expanded beyond the terminal tripeptide.
messages: Peroxisome matrix

559292:YGL257C
gene id: 559292:YGL257C
uniprot id: P53059
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans.
messages: Present with 1170 molecules/cell in log phase SD medium.

559292:YGL212W
gene id: 559292:YGL212W
uniprot id: P32912
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.
messages: Possibly multimeric. Associates with VAM3.
messages: Present with 2360 molecules/cell in log phase SD medium.
messages: Vacuole

559292:YER053C
gene id: 559292:YER053C
uniprot id: P40035
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Present with 2360 molecules/cell in log phase SD medium.
messages: Transport of phosphate groups from the cytosol to the mitochondrial matrix.

559292:YPL007C
gene id: 559292:YPL007C
uniprot id: Q12308
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with TFC6. Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with SPT15 and directly with TFC6.
messages: Nucleus
messages: Present with 2070 molecules/cell in log phase SD medium.
messages: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Plays a role in TFIIB assembly through its interaction with SPT15/TBP. Essential for cell viability.

559292:YJR026W
gene id: 559292:YJR026W
uniprot id: P0CX74
uniprot id: P0CX75
uniprot id: P0CX76
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-JR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR3 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ML2 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YDR246W
gene id: 559292:YDR246W
uniprot id: Q03784
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
messages: Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.
messages: Preautophagosomal structure
messages: Present with 3130 molecules/cell in log phase SD medium.
messages: cis-Golgi network

559292:YDL212W
gene id: 559292:YDL212W
uniprot id: Q02774
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Involved in amino acid permease processing and required for the efficient translocation of structurally related amino acid permeases from the endoplasmic reticulum to the plasma membrane. SHR3 may function as a permease-specific 'adaptor' molecule that functions in conjunction with the SEC62/SEC63 complex. Yeast cells may require SHR3 to expedite the processing of permeases to ensure their rapid expression at the plasma membrane in response to changing environmental conditions.
messages: Monomer.
messages: Present with 6510 molecules/cell in log phase SD medium.

559292:YBR027C
gene id: 559292:YBR027C
uniprot id: P38220
names: Subcellular Location Annotation
messages: Membrane

559292:YDR083W
gene id: 559292:YDR083W
uniprot id: P38961
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Present with 2780 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 645 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Also involved in telomere length regulation and maintenance.
messages: nucleolus
messages: telomere

559292:YHR116W
gene id: 559292:YHR116W
uniprot id: P38824
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX23 family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Present with 1360 molecules/cell in log phase SD medium.
messages: Required for the assembly of cytochrome c oxidase.

559292:YER190W
gene id: 559292:YER190W
uniprot id: P40105
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YGR245C
gene id: 559292:YGR245C
uniprot id: P53313
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the 60S pre-ribosomal particles. Interacts with NAP1.
messages: Belongs to the SDA1 family.
messages: Present with 3640 molecules/cell in log phase SD medium.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm. May also be required for 60S ribosomal subunit maturation and accumulation. Involved in G1 events and passage through start, and possibly actin cytoskeleton organization.
messages: nucleolus

559292:YCR088W
gene id: 559292:YCR088W
uniprot id: P15891
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABP1 family.
messages: Binds F-actin, but not G-actin. Interacts with the ARP2/3 complex. Interacts with APP1, ARK1, PRK1, SCP1, SRV2 and YIR003W via its SH3 domain. Interacts with the SH3 domain of RVS167 and with SLA1.
messages: Present with 606 molecules/cell in log phase SD medium.
messages: Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.
messages: The actin depolymerizing factor homology (ADF) domain mediates actin filament binding.
messages: actin patch

559292:YPL176C
gene id: 559292:YPL176C
uniprot id: Q08919
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YER002W
gene id: 559292:YER002W
uniprot id: P40007
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP16 family.
messages: Component of the pre-66S ribosomal particle. Interacts with NOP7, RRP1 and RRP15 (By similarity).
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: Present with 2860 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YNL213C
gene id: 559292:YNL213C
uniprot id: P40156
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG9 family.
messages: Mitochondrion
messages: Present with 1160 molecules/cell in log phase SD medium.
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

559292:YHR211W
gene id: 559292:YHR211W
uniprot id: P38894
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flocculin family.
messages: Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose.
messages: Extensively O-glycosylated.
messages: For many industrial applications in which the yeast S.cerevisiae is used, e.g. beer, wine and alcohol production, appropriate flocculation behavior is one of the most important characteristics of a good production strain. The ability of yeast cells to flocculate is of considerable importance, as it provides an effective, environment-friendly, simple and cost-free way to separate yeast cells from the fermentation product at the end of fermentation.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains. There is a linear correlation between protein size and the extend of adhesion: the more repeats, the stronger the adhesion properties and the greater the fraction of flocculating cells (By similarity).
messages: cell wall

559292:YJL105W
gene id: 559292:YJL105W
uniprot id: P42948
names: Function
names: Similarity
messages: Belongs to the SET3 family.
messages: Putative chromatin regulator.

559292:YKL011C
gene id: 559292:YKL011C
uniprot id: Q03702
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' sequence.
messages: Homodimer.
messages: Mitochondrion

559292:YLR039C
gene id: 559292:YLR039C
uniprot id: P40395
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIC1 family. Highly divergent.
messages: Forms a complex with RGP1.
messages: Golgi apparatus membrane
messages: Present with 78 molecules/cell in log phase SD medium.
messages: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment. May also be indirectly involved in the transcription of both ribosomal protein genes and ribosomal RNA.

559292:YMR060C
gene id: 559292:YMR060C
uniprot id: P50110
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which at least consists of SAM35, SAM37 and SAM50. SAM37 interacts with TOM70.
messages: Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.
messages: Mitochondrion outer membrane
messages: Present with 1580 molecules/cell in log phase SD medium.

559292:YMR101C
gene id: 559292:YMR101C
uniprot id: Q03175
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Expression is induced in the stationary phase.
messages: Forms an active dehydrodolichyl diphosphate synthase complex with NUS1.
messages: Lipid droplet
messages: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).

559292:YNR032C-A
gene id: 559292:YNR032C-A
uniprot id: Q6Q546
names: Function
messages: Forms conjugate with SPH1 and HBT1. Involved in morphogenesis.

559292:YOR299W
gene id: 559292:YOR299W
uniprot id: Q08754
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHAPS family.
messages: Component of the CHS5/6 complex composed of the 4 CHAPS proteins BCH1, BCH2v, BUD7, and CHS6 as well as at least CHS5 and GTP-bound ARF1. The complex interacts with the cargo protein CHS3.
messages: Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3. May be involved in positioning the proximal bud pole signal.
messages: Present with 2070 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YBR220C
gene id: 559292:YBR220C
uniprot id: P38318
names: Subcellular Location Annotation
messages: Membrane

559292:YGR212W
gene id: 559292:YGR212W
uniprot id: P53304
names: Function
names: Subcellular Location Annotation
messages: Confers resistance to the sphingolipid biosynthesis inhibitor drug myriocin (ISP-1). Inactivates ISP-1 by converting it into N-acetyl-myriocin. Cooperates with YPK1 in mediating resistance to myriocin.
messages: Endoplasmic reticulum

559292:YCL032W
gene id: 559292:YCL032W
uniprot id: P25344
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts with STE11 through the respective SAM domains.
messages: Involved in growth arrest during conjugation. May interact with the G protein alpha subunit.
messages: Present with 1670 molecules/cell in log phase SD medium.

559292:YKR091W
gene id: 559292:YKR091W
uniprot id: P36167
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with CLN2.
messages: Phosphorylated by CDC28, probably in association with G1 cyclin CLN2.
messages: Weakly suppresses a RAD53 null mutation when overexpressed.

559292:YBR192W
gene id: 559292:YBR192W
uniprot id: P38127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane

559292:YDR244W
gene id: 559292:YDR244W
uniprot id: P35056
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex.
messages: Monoubiquitinated at Cys-6 by PEX2 during PEX5 passage through the retrotranslocation channel: monoubiquitination acts as a signal for PEX5 extraction and is required for proper export from peroxisomes and recycling (PubMed:15632140, PubMed:17452527, PubMed:35768507). Ubiquitination at Cys-6 is UBC4-independent but requires the presence of PEX4 (PubMed:17550898, PubMed:17452527). When PEX5 recycling is compromised, polyubiquitinated at Lys-18 and Lys-24 by PEX10 during its passage through the retrotranslocation channel, leading to its degradation (PubMed:15283676, PubMed:15536088, PubMed:17452527, PubMed:35768507). Ubiquitination at Lys-18 and Lys-24 are UBC4-dependent (PubMed:15283676, PubMed:15536088, PubMed:17550898). Monoubiquitination at Cys-6 and polyubiquitination at Lys-18 and Lys-24 are removed by UBP15 in the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:21665945).
messages: Peroxisome matrix
messages: Present with 2070 molecules/cell in log phase SD medium.
messages: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:8265627, PubMed:7980572, PubMed:14562106, PubMed:35768507). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:9094717). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:35768507).
messages: The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type).
messages: The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex.
messages: The amphipathic helix 1 and 2 (AH1 and AH2, respectively) are required for PEX5 retrotranslocation and recycling. AH2 mediates interaction with lumenal side of the PEX2-PEX10-PEX12 ligase complex, while AH1 is required for extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex.
messages: cytosol

559292:YLR049C
gene id: 559292:YLR049C
uniprot id: Q12110
names: Miscellaneous
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YOR089C
gene id: 559292:YOR089C
uniprot id: P36017
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by the guanine nucleotide-exchange factor (GEF) VPS9 and inactivated by GTPase-activating proteins (GAPs) GYP1 and GYP3.
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome membrane
messages: Interacts in its active GTP-bound form with PEP7/VAC1.
messages: Mitochondrion membrane
messages: Present with 8759 molecules/cell in log phase SD medium.
messages: Required for protein transport to the vacuole. Involved in two vesicle trafficking steps to the prevacuolar compartment (PVC), regulating the docking of endosomes and Golgi vesicles to the PVC by interacting with PEP7/VAC1 on the PVC membrane and promoting SNARE complex formation.

559292:YPR056W
gene id: 559292:YPR056W
uniprot id: Q12004
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

559292:YER152C
gene id: 559292:YER152C
uniprot id: P10356
names: Miscellaneous
messages: Present with 1390 molecules/cell in log phase SD medium.

559292:YLR457C
gene id: 559292:YLR457C
uniprot id: P52919
names: Miscellaneous
names: Subunit
messages: Interacts with NDC1 and MPS2.
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YGL243W
gene id: 559292:YGL243W
uniprot id: P53065
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ADAT1 family.
messages: Binds 1 myo-inositol hexakisphosphate (IP6) per subunit.
messages: Deaminates adenosine-37 to inosine in tRNA-Ala.

559292:YGR062C
gene id: 559292:YGR062C
uniprot id: P53239
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Interacts with PNT1 and MSS2.
messages: Mitochondrion inner membrane
messages: Present with 468 molecules/cell in log phase SD medium.
messages: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space.

559292:YMR021C
gene id: 559292:YMR021C
uniprot id: P35192
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 14800 molecules/cell in log phase SD medium.
messages: Regulatory protein involved in Cu/Fe utilization and stress resistance. Involved in basal level transcription of FRE1 and H(2)O(2)-induced transcription of CTT1. Regulates the transcription of CTR1 and CTR3 via the copper ion responsive elements in their promoters. Required for degradation of CTR1.

559292:YLR441C
gene id: 559292:YLR441C
uniprot id: P33442
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS1 interacts directly with uS11 and eS26, which form part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 92400 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS1 in yeast.

559292:YER043C
gene id: 559292:YER043C
uniprot id: P39954
names: Cofactor
names: Function
names: Similarity
messages: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

559292:YGR038C-B
gene id: 559292:YGR038C-B
uniprot id: Q12269
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YGR038C-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YIL109C
gene id: 559292:YIL109C
uniprot id: P40482
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC24 specifically recruits cargo proteins like BET1 or SYS1 to the COPII vesicles. The SEC23/24 complex is also involved in internalization of plasma membrane proteins like the maltose transporter.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: The COPII coat is composed of at least 7 proteins: the SEC23/24 complex, the SEC13/31 complex, SFB2, SFB3 and the protein SAR1. Interacts with BET1, EMP24, GRH1, SEC22, SED5 and SYS1.

559292:YJR027W
gene id: 559292:YJR027W
uniprot id: P47098
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YJR026W ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YML103C
gene id: 559292:YML103C
uniprot id: P52593
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nup188 family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. Interacts with POM152 and NIC96.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP188 probably plays an important role in NPC assembly and organization.
messages: Nucleus membrane
messages: Present with 11700 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YNR057C
gene id: 559292:YNR057C
uniprot id: P53630
names: Function
names: Similarity
messages: Belongs to the dethiobiotin synthetase family.
messages: Dethiobiotin synthetase involved in the biotin biosynthesis pathway.

559292:YOR084W
gene id: 559292:YOR084W
uniprot id: Q12405
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Aberrant morphology characterized by intraperoxisomal vesicles or invaginations.
messages: By oleic acid. Transcriptionally up-regulated by YRM1 along with genes involved in multidrug resistance. Expression is also dependent on RSF1 and RSF2 for transcriptional induction during growth on glycerol-based medium.
messages: Has acyl esterase, lipase and phospholipase A activity.
messages: Peroxisome matrix
messages: Present with 2350 molecules/cell in log phase SD medium.

559292:YDL007W
gene id: 559292:YDL007W
uniprot id: P40327
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Has ATPase activity.

559292:YIL022W
gene id: 559292:YIL022W
uniprot id: Q01852
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim44 family.
messages: Component of the PAM complex, at least composed of SSC1 (mtHsp70), MGE1, TIM44, PAM16/TIM16, PAM17 and PAM18/TIM14. Forms part of the receptor complex that consists of at least 3 different proteins (TIM17, TIM23, TIM44).
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source.
messages: Mitochondrion inner membrane

559292:YLL018C
gene id: 559292:YLL018C
uniprot id: P04802
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Present with 5750 molecules/cell in log phase SD medium.

559292:YLR304C
gene id: 559292:YLR304C
uniprot id: P19414
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle. Can also provide minor contributions to the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. Also plays an essential role in mtDNA maintenance. May directly protect mtDNA from accumulation of point mutations and ssDNA breaks as a component of mitochondrial nucleoids, or by preventing accumulation of iron citrate thereby alleviating its detrimental effects in mitochondria.
messages: Cytoplasm
messages: Essential for growth on nonfermentable carbon sources and for biosynthesis of glutamate. Causes a dramatic increase in cellular citrate levels.
messages: Highly induced in the absence of glutamate. Induction is further increased when both glutamate and lysine are missing.
messages: Mitochondrion
messages: Monomer. Binds to mitochondrial DNA (mtDNA) and identified as component of mitochondrial nucleoids.
messages: Present with 96700 molecules/cell in log phase SD medium.
messages: Subject to catabolite regulation.
messages: The fermenting yeast S.cerevisiae has 2 aconitases, ACO1 essential for the citric acid cycle, and ACO2 specifically and exclusively contributing to lysine biosynthesis. In contrast, in respiring filamentous fungi the ACO2 homologs (acoB) seem enzymatically inactive and the ACO1 homolog (acoA) is solely responsible for these functions.

559292:YBL105C
gene id: 559292:YBL105C
uniprot id: P24583
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Required for cell growth and for the G2->M transition of the cell division cycle. Mediates a protein kinase cascade; it activates BCK1 which itself activates MKK1/MKK2.

559292:YDR379W
gene id: 559292:YDR379W
uniprot id: Q06407
names: Function
names: Miscellaneous
messages: GTPase-activating protein (GAP) for CDC42 and/or RHO1.
messages: Present with 254 molecules/cell in log phase SD medium.

559292:YPL019C
gene id: 559292:YPL019C
uniprot id: Q02725
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046). The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046). PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834). The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules. Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).
messages: Belongs to the VTC2/3 family.
messages: By low phosphate.
messages: Endoplasmic reticulum membrane
messages: Present with 2630 molecules/cell in log phase SD medium.
messages: The SPX domain has very high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7), and moderate affinity for inorganic pyrophosphate. Its affinity for inorganic phosphate is 2 to 3 orders of magnitude lower (Probable). SPX domains may integrate inositol pyrophosphates (PP-InsP)-dependent signaling to adapt cytosolic phosphate concentrations to different metabolic situations (Probable).
messages: The VTC core complex is an integral membrane heterooligomer composed of the catalytic subunit VTC4 and the accessory subunits VTC1, VTC2 and VTC3. The complex exists in 2 different sub-complexes: VTC1-VTC2-VCT4 and VCT1-VTC3-VTC4. The VCT1-VTC3-VTC4 subcomplex is mostly found on the vacuolar membrane. The VTC1-VTC2-VCT4 subcomplex is observed in the cell periphery, probably ER and nuclear envelope, but localizes to the vacuole under phosphate starvation. Each subunit contains 3 transmembrane helices. VTC1 is a small membrane protein without hydrophilic domain. VTC2, VTC3 and VTC4 are related and have 2 hydrophilic domains that face the cytosol, an N-terminal SPX domain and the central core domain. The central core in VTC4 is the catalytic domain, with the essential catalytic lysine replaced by isoleucine and leucine in VTC2 and VTC3, respectively (PubMed:19390046). The core complex associates with the accessory subunit VTC5 (PubMed:27587415). The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1 (PubMed:11823419).
messages: Vacuole membrane
messages: autophagosome membrane
messages: cell cortex

559292:YJL131C
gene id: 559292:YJL131C
uniprot id: P47015
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM23 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YPR196W
gene id: 559292:YPR196W
uniprot id: Q06595
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL13 family.
messages: May regulate the transcription of maltase and maltose permease genes.
messages: Nucleus
messages: The gene is not associated with corresponding maltase and maltose permease genes on chromosome 16 as it is the case for the other functional maltose fermentation loci, so its transcription regulation activity is speculative.

559292:YGL240W
gene id: 559292:YGL240W
uniprot id: P53068
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. DOC1 is required, together with the coactivators CDH1 and CDC20, for recognition and binding of the substrates.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1364 molecules/cell in log phase SD medium.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1.

559292:YJL212C
gene id: 559292:YJL212C
uniprot id: P40897
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Cell membrane
messages: High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly_Phe-Met) across the cell membrane.
messages: Present with 2870 molecules/cell in log phase SD medium.

559292:YLR387C
gene id: 559292:YLR387C
uniprot id: Q06709
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with nascent pre-60S particles that have not yet entered the translating pool, and is released from mature 60S subunits. Interacts with pre-60S factors NMD3, LSG1, and TIF6.
messages: Belongs to the REI1 family.
messages: Cytoplasm
messages: Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. May act redundantly with REI1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on the REI1-specific ARX1 recycling.
messages: Present with 2240 molecules/cell in log phase SD medium.

559292:YJL136C
gene id: 559292:YJL136C
uniprot id: Q3E754
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (PubMed:14627813).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatB.
messages: Present with 15300 molecules/cell in log phase SD medium.
messages: Reduction in growth rate, a decrease in free 40S subunits, an increase in the amount of free 60S subunits and a decrease in polysome size.
messages: There are 2 genes for eS21 in yeast.

559292:YGR081C
gene id: 559292:YGR081C
uniprot id: P53251
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX9 family.
messages: Interacts with the 35S, 23S and 20S pre-rRNAs and with the U3 snoRNA.
messages: Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks.
messages: Present with 3670 molecules/cell in log phase SD medium.
messages: Transiently up-regulated during the initial 15 minutes of dough-fermentation.
messages: nucleolus

559292:YJR085C
gene id: 559292:YJR085C
uniprot id: P47131
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM14 family.
messages: By the DNA-damaging agent methyl methanesulphonate (MMS) (at protein level).
messages: Membrane
messages: Mitochondrion
messages: Present with 2100 molecules/cell in log phase SD medium.

559292:YKR015C
gene id: 559292:YKR015C
uniprot id: P36111
names: Similarity
messages: To yeast YJL043w.

559292:YPR020W
gene id: 559292:YPR020W
uniprot id: Q12233
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase g subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane
messages: Phosphorylation on Ser-62 impairs ATP synthase dimerization.

559292:YBR128C
gene id: 559292:YBR128C
uniprot id: P38270
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG14 family.
messages: Coiled-Coils at the N-terminal half are essential for interaction with VPS30 and VPS34 and autophagy.
messages: Component of the autophagy-specific VPS34 PI3-kinase complex I composed of VPS15, VPS30, VPS34, ATG14 and ATG38. Interacts directly with ATG38.
messages: Nitrogen starvation or rapamycin treatment rapidly causes a more than 20-fold induction of expression. The expression is dependent on GLN3.
messages: Preautophagosomal structure membrane
messages: Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS).
messages: Vacuole membrane

559292:YNL298W
gene id: 559292:YNL298W
uniprot id: P48562
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Interacts with CDC42.
messages: Involved in budding and cytokinesis.

559292:YBR297W
gene id: 559292:YBR297W
uniprot id: P38157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL13 family.
messages: Nucleus
messages: Regulates the coordinate transcription of structural MAL3S (maltase) and MAL3T (maltose permease) genes.

559292:YDL067C
gene id: 559292:YDL067C
uniprot id: P07255
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal cytochrome c oxidase subunit 7a family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: Present with 35500 molecules/cell in log phase SD medium.

559292:YOR155C
gene id: 559292:YOR155C
uniprot id: Q99312
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by ATP (PubMed:8141771). ATP binding is a prerequisite to magnesium and substrate binding (By similarity). ATP binds to 2 of the subunits in the homotetramer inducing a closure of these 2 subunits and the release of the C-terminal loop, thereby activating the enzyme (By similarity).
messages: Belongs to the ISN1 family.
messages: Homotetramer.
messages: IMP-specific 5'-nucleotidase involved in IMP (inosine 5'-phosphate) degradation.
messages: Present with 1590 molecules/cell in log phase SD medium.

559292:YCR061W
gene id: 559292:YCR061W
uniprot id: P25639
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: To S.pombe SpBC3B8.06.

559292:YDR435C
gene id: 559292:YDR435C
uniprot id: Q04081
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Inhibited by S-adenosyl-L-homocysteine.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Acts on the two major protein phosphatase 2A catalytic subunits, PPH21 and PPH22.

559292:YOR032C
gene id: 559292:YOR032C
uniprot id: Q12398
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the G1/S-specific cyclin PCL1.
messages: Involved in exit from mitosis and pseudohyphal differentiation.
messages: Nucleus
messages: Phosphorylated by the cyclin-CDK complex PCL1-PHO85.

559292:YOR176W
gene id: 559292:YOR176W
uniprot id: P16622
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acidic phospholipids or fatty acids are important for the ferrochelatase activity.
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Ferrochelatase interacts with protoprophyrinogen oxidase, and associates with complex 1 of the respiratory chain.
messages: Mitochondrion inner membrane
messages: Present with 22700 molecules/cell in log phase SD medium.
messages: The leader peptide may be processed in two proteolytic steps, first between Ser-23 and Phe-24, second and by a different protease, to yield the mature protein.

559292:YJR107W
gene id: 559292:YJR107W
uniprot id: P47145
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lipases catalyze the hydrolysis of the ester bond of tri-, di- and monoglycerides of long-chain fatty acids into fatty acids and glycerol.

559292:YFR050C
gene id: 559292:YFR050C
uniprot id: P30657
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: It is uncertain whether Met-1 or Met-31 is the initiator.
messages: Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. PRE3 and PRE4 are necessary for the peptidyl-glutamyl-peptide-hydrolyzing activity.
messages: Nucleus
messages: Present with 16900 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with CIC1.

559292:YHL009C
gene id: 559292:YHL009C
uniprot id: P38749
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. YAP subfamily.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with the C-terminal, cytoplasmic tail of the multidrug resistance ABC transporter PDR5.
messages: Nucleus
messages: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
messages: Present with 1700 molecules/cell in log phase SD medium.
messages: Transcription activator involved in the regulation of genes expressed in response to environmental changes. When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide. When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) (By similarity). Preferentially binds 5'-TTACTAA-3'.

559292:YHL038C
gene id: 559292:YHL038C
uniprot id: P03874
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Appears to be specifically required for the splicing of the terminal intron (bI5) of the cytochrome b pre-mRNA. Can also stimulates the splicing of the omega intron of the precursor of large ribosomal RNA.
messages: Mitochondrion
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YNL281W
gene id: 559292:YNL281W
uniprot id: P53834
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AHA1 family.
messages: Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting.
messages: Cytoplasm
messages: Monomer. Interacts with HSP82.
messages: Nucleus
messages: Present with 8528 molecules/cell in log phase SD medium.

559292:YDR117C
gene id: 559292:YDR117C
uniprot id: Q04600
names: Domain
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eIF2D family.
messages: Interacts with the 40S ribosomal subunit.
messages: Present with 3870 molecules/cell in log phase SD medium.
messages: The PUA and the SUI1 domains may be involved in RNA binding.

559292:YLR276C
gene id: 559292:YLR276C
uniprot id: Q06218
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
messages: Interacts with DBP6.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YGL238W
gene id: 559292:YGL238W
uniprot id: P33307
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPO2/CSE1 family.
messages: Binds with high affinity to SRP1 only in the presence of RanGTP. The complex is dissociated by the RanGTP-binding protein YRB1.
messages: Cytoplasm
messages: Export receptor for importin alpha (SRP1). Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm.
messages: Nucleus
messages: Present with 23500 molecules/cell in log phase SD medium.

559292:YOR383C
gene id: 559292:YOR383C
uniprot id: Q08907
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: By iron.
messages: Involved in the uptake of non-siderophore and siderophore sources of iron. Has a role in the retention of iron in the cell wall and periplasmic space.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

559292:YNL311C
gene id: 559292:YNL311C
uniprot id: P42843
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with SKP1. Component of the probable SCF(SKP2) complex containing CDC53, SKP1, RBX1 and SKP2. May interact with ribosomes.
messages: Present with 432 molecules/cell in log phase SD medium.
messages: Stabilizes the adenosylphosphosulfate kinase MET14 which leads to accumulation H(2)S and SO(2).
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Regulates protein levels of sulfur metabolism enzymes. The SCF(SKP2) complex may regulate some transcription factors or regulators of cysteine and methionine biosynthesis.

559292:YNL055C
gene id: 559292:YNL055C
uniprot id: P04840
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Consists mainly of membrane-spanning sided beta-sheets. 19 strands distributed along the entire VDAC protein, have the potential to adopt transmembrane beta pleated sheet structures, which rolled together may form a 'beta-barrel' type structure, possessing pore dimensions.
messages: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Is the major permeability factor of the mitochondrial outer membrane.
messages: Interacts with AIM5, FCJ1 and MOS1.
messages: Mitochondrion outer membrane

559292:YOL064C
gene id: 559292:YOL064C
uniprot id: P32179
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily.
messages: By salt stress.
messages: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance. Confers resistance to lithium.
messages: Cytoplasm
messages: Nucleus
messages: Present with 7330 molecules/cell in log phase SD medium.

559292:YKL112W
gene id: 559292:YKL112W
uniprot id: P14164
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BAF1 family.
messages: Component of the global genome repair (GGR) complex composed of at least ABF1, RAD7 and RAD16. Interacts with PSE1.
messages: Contains 2 important clusters of amino acid residues in the C terminus (C-terminal sequence 1 or CS1, residues 624 to 628; and CS2, residues 639 to 662). CS1 specifically participates in transcriptional silencing and/or repression in a context-dependent manner, whereas CS2 is universally required for all functions of ABF1.
messages: Extensively phosphorylated on Ser and Thr residues.
messages: General regulatory factor (GRF) that contributes to transcriptional activation of a large number of genes, as well as to DNA replication, silencing and telomere structure. Involved in the transcription activation of a subset of ribosomal protein genes. Binds the ARS-elements found in many promoters. Binds to the sequence 5'-TCN(7)ACG-3'. Influences on genome-wide nucleosome occupancy and affects chromatin structure, and probably dynamics. As a component of the global genome repair (GGR) complex, promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Component of the regulatory network controlling mitotic and meiotic cell cycle progression.
messages: Nucleus
messages: Present with 4820 molecules/cell in log phase SD medium.

559292:YKL185W
gene id: 559292:YKL185W
uniprot id: P34233
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. ASH1 is necessary to repress HO in daughter cells to block mating-type switching through its binding to HO promoter 5'-YTGAT-3' sites. Also involved in pseudohyphal growth.
messages: Nucleus
messages: Present with 1800 molecules/cell in log phase SD medium.
messages: The ASH1 mRNA is transported to the daughter cell before cytokinesis where translation produces the protein to block mating-type switching. The ASH1 mRNA 3'-UTR and the mRNA localization machinery that are essential to restrict accumulation to the bud.

559292:YJL111W
gene id: 559292:YJL111W
uniprot id: P42943
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation (By similarity).

559292:YGL054C
gene id: 559292:YGL054C
uniprot id: P53173
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells.
messages: Defects in cell polarity. Strains homozygous for ERV14 deletion do not sporulate.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Present with 7110 molecules/cell in log phase SD medium.

559292:YNL152W
gene id: 559292:YNL152W
uniprot id: P53901
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INN1/fic1 family.
messages: Bud neck
messages: Interacts with CYK2, CYK3 and IQG1.
messages: Required for the ingression of the plasma membrane into the bud neck at the end of cytokinesis, leading to the separation of the mother and daughter cells. Stimulates the synthesis of the primary septum (PS) by CHS2.
messages: The C2 domain is essential for membrane ingression during cytokinesis, but not for recruitment to the actomyosin ring.

559292:YDL237W
gene id: 559292:YDL237W
uniprot id: Q07716
names: Disruption Phenotype
names: Similarity
messages: Belongs to the AIM6 family.
messages: Impairs respiratory growth.

559292:YHL025W
gene id: 559292:YHL025W
uniprot id: P18888
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Nucleus
messages: Partially functional.
messages: Present with 2900 molecules/cell in log phase SD medium.

559292:YBR154C
gene id: 559292:YBR154C
uniprot id: P20434
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerase complexes are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

559292:YJL093C
gene id: 559292:YJL093C
uniprot id: P40310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: Outwardly rectifying potassium channel.

559292:YPL253C
gene id: 559292:YPL253C
uniprot id: Q12045
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KAR3.
messages: Nucleus
messages: Targets and/or maintains KAR3 at the spindle pole body during vegetative growth.
messages: spindle pole body

559292:YHR120W
gene id: 559292:YHR120W
uniprot id: P25846
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Homodimer.
messages: Important for mitochondrial DNA (mtDNA) stability and repair. Recognizes and binds to base-base and small insertion-deletion mismatches in mtDNA. ATP binding and hydrolysis is crucial for function. Binding to a mismatched base pair attenuates ATP hydrolysis. Also involved in proper sorting of mtDNA during mtDNA transmission.
messages: Mitochondrion
messages: Present with 1670 molecules/cell in log phase SD medium.

559292:YDR342C
gene id: 559292:YDR342C
uniprot id: P39004
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: High-affinity glucose transporter.
messages: Membrane
messages: Present with 7350 molecules/cell in log phase SD medium.

559292:YPL224C
gene id: 559292:YPL224C
uniprot id: Q08970
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Mitochondrial metal transporter involved in mitochondrial iron accumulation.
messages: Mitochondrion membrane

559292:YIL140W
gene id: 559292:YIL140W
uniprot id: P38928
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Expression shows a peak at the start of the cell cycle just before bud emergence in late G1 phase.
messages: Interacts with BEM1, BUD3, BUD4, BUD5, CDC24 and CDC42.
messages: O-glycosylated by PMT4 and N-glycosylated. O-glycosylation increases activity in daughter cells by enhancing stability and promoting localization to the plasma membrane. May also be O-glycosylated by PMT1 and PMT2.
messages: Present with 396 molecules/cell in log phase SD medium.
messages: Ref.5 refers to this gene as REV7. REV7 is however the adjacent gene.
messages: Required for haploid cells axial budding pattern. Acts as an anchor to help direct new growth components and/or polarity establishment components like the BUD5 GTP/GDP exchange factor to localize at the cortical axial budding site. Regulates septin organization in late G1 independently of its role in polarity-axis determination.

559292:YGL020C
gene id: 559292:YGL020C
uniprot id: P53192
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WRB/GET1 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Mitochondrion membrane
messages: Present with 2250 molecules/cell in log phase SD medium.
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology.

559292:YER099C
gene id: 559292:YER099C
uniprot id: P38620
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Cytoplasm
messages: Present with 8120 molecules/cell in log phase SD medium.

559292:YKR016W
gene id: 559292:YKR016W
uniprot id: P36112
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex. Interacts with TOM22 and TOM40 in a MICOS-independent manner, resulting in coupling with the outer membrane. Interacts with MIA40, OM45 and POR1.
messages: Increases frequency of mitochondrial genome loss and leads to altered mitochondrial morphology. Moderately reduces mitochondrial membrane potential and import efficiency of preproteins that are transported into or across the inner membrane via TIM23 complex. Impairs precursor protein import via the MIA pathway. 60-70% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.
messages: Mitochondrion inner membrane
messages: Present with 5730 molecules/cell in log phase SD medium.

559292:YDL012C
gene id: 559292:YDL012C
uniprot id: Q12489
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Cell membrane
messages: Present with 2250 molecules/cell in log phase SD medium.

559292:YER125W
gene id: 559292:YER125W
uniprot id: P39940
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cysteine residue is required for ubiquitin-thioester formation.
messages: Belongs to the RSP5/NEDD4 family.
messages: Component of the RSP5-BUL1/2 ubiquitin ligase complex composed of at least RSP5 and BUL1 or BUL2 (PubMed:8668140, PubMed:9931424). Component of the RSP5-UBA1-UBC5 ubiquitin ligase complex composed of E3 RSP5, E1 UBA1 and E2 UBC5 (Probable). Forms also a ternary complex with RUP1 and UBP2 (PubMed:15933713). Interacts (via WW domains) with LSB1 (PubMed:22000681). Interacts (via WW domains) with PIN3/LSB2 (PubMed:22000681). Interacts (via WW domains) with RCR1 (via PY motifs) (PubMed:17213653). Interacts with UBP2; the interaction is direct (PubMed:19920177). Interacts with HSE1 (PubMed:15086794, PubMed:17079730). Interacts with LAS17 (PubMed:22000681). Interacts with ROG3 (PubMed:12163175). Interacts with ROD1 (PubMed:12163175). Interacts with RVS167 (PubMed:22000681). Interacts with ubiquitin (PubMed:21399621).
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:19920177, PubMed:7708685, PubMed:15933713). Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other cell surface proteins like GAP1, FUR4, MAL61, PMA1 and STE2 (PubMed:8596462). The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription, pressure-induced differential regulation of the two tryptophan permeases TAT1 and TAT2 and sorting efficiency into multivesicular bodies (PubMed:15247235, PubMed:16864574, PubMed:17079730, PubMed:14560004, PubMed:12821147, PubMed:15020711, PubMed:9931424). The RSP5-UBA1-UBC5 ubiquitin ligase complex ubiquitinates RPO21 forming 'Lys-63'-linked polyubiquitin chains (PubMed:19920177, PubMed:9858558). Plays a role in tolerance to o-dinitrobenzene (PubMed:12163175). Involved in actin cytoskeleton organization and dynamics (PubMed:22000681). Ubiquitinates the LAS17-binding proteins LSB1 and PIN3/LSB2 without directing them for degradation and affects LAS17 levels in a SLA1-dependent and LSB1/2-independent manner (PubMed:22000681).
messages: Nucleus
messages: The ubiquitination appears to be the result of an intramolecular transfer of ubiquitin.
messages: actin patch

559292:YOR362C
gene id: 559292:YOR362C
uniprot id: P21242
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 12000 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
messages: The alpha and beta forms are probably products of the same gene with different post-translational modifications.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

559292:YJL219W
gene id: 559292:YJL219W
uniprot id: P40885
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Probable glucose transporter.

559292:YNL234W
gene id: 559292:YNL234W
uniprot id: P53857
names: Miscellaneous
names: Similarity
messages: Belongs to the globin family.
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YGL107C
gene id: 559292:YGL107C
uniprot id: P53140
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal meiosis.
messages: Belongs to the RMD9 family.
messages: Binds the RNA motif 5'-AAUAA[U/C]AUUCUU-3' in the 3'-UTR of mitochondrial mRNAs (PubMed:33876744, PubMed:10441495, PubMed:10905425). Involved in the processing or stability of mitochondrial mRNAs (PubMed:33876744, PubMed:17194787, PubMed:17194786).
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Phosphorylated (PubMed:10905425). Phosphorylation promotes binding to RNA (PubMed:10905425).
messages: Present with 4800 molecules/cell in log phase SD medium.

559292:YJL013C
gene id: 559292:YJL013C
uniprot id: P47074
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the mitotic checkpoint complex (MCC) which consists of MAD2, MAD3, BUB3 and CDC20. Interacts with CDC20 and BUB3.
messages: Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20.
messages: Nucleus
messages: Present with 3170 molecules/cell in log phase SD medium.
messages: To yeast protein kinase BUB1 in its non-catalytic N-terminal domain.

559292:YOR081C
gene id: 559292:YOR081C
uniprot id: Q12043
names: Activity Regulation
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Lipid droplet
messages: Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate metabolic pathways (PubMed:16135509). Also catalyzes the acylation of lysophosphatidic acid (LPA) (PubMed:20016004).
messages: Loses its lipolytic activity in cells lacking nonpolar lipids, but retains its side activity as lysophospholipid acyltransferase.
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YKL087C
gene id: 559292:YKL087C
uniprot id: Q00873
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C1 apoprotein to produce the mature functional cytochrome.
messages: Mitochondrion inner membrane

559292:YNL223W
gene id: 559292:YNL223W
uniprot id: P53867
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8 (PubMed:11038174, PubMed:11100732, PubMed:11149920, PubMed:11904149, PubMed:16680092, PubMed:18701704, PubMed:18725539, PubMed:8050581, PubMed:8224160, PubMed:9649430, PubMed:28330855, PubMed:28821724, PubMed:28704456). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:11038174, PubMed:11100732, PubMed:11149920, PubMed:11904149, PubMed:16680092, PubMed:18701704, PubMed:18725539, PubMed:8050581, PubMed:8224160, PubMed:9649430). The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine (PubMed:11038174, PubMed:11100732, PubMed:11149920, PubMed:11904149, PubMed:16680092, PubMed:18701704, PubMed:18725539, PubMed:8050581, PubMed:8224160, PubMed:9649430). ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy (PubMed:11038174, PubMed:11100732, PubMed:11149920, PubMed:11904149, PubMed:16680092, PubMed:18701704, PubMed:18725539, PubMed:8050581, PubMed:8224160, PubMed:9649430). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (PubMed:17632063). In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophago…
messages: Cytoplasm
messages: Expression is induced upon starvation, through the action of transcription factors GCN2 and GCN4.
messages: Formation of a disulfide bond between Cys-338 and Cys-394 leads to reduced autophagy (PubMed:25483965). The disulfide bond is reduced by thioredoxin (PubMed:25483965).
messages: Inhibited by N-ethylmaleimide.
messages: Interacts with ATG8 (PubMed:16680092, PubMed:9649430, PubMed:28287329, PubMed:28330855, PubMed:28821724). Interacts with TUB1 and TUB2 (PubMed:9649430).
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylation at Ser-307 by ATG1 inhibits autophagy: it takes place on autophagosome membranes and decreases its interaction with ATG8, thereby impairing deconjugation of PE-conjugated forms of ATG8.
messages: Preautophagosomal structure
messages: Present with 3300 molecules/cell in log phase SD medium.
messages: The APEAR motif (ATG8-PE association region) plays a key role in ATG4 recruitment to autophagosomal membranes and ATG8 deconjugation (PubMed:28330855). The LIR (LC3-interacting region act cooperatively) and APEAR motifs for the interaction with ATG8 (PubMed:28287329, PubMed:28330855).

559292:YDR091C
gene id: 559292:YDR091C
uniprot id: Q03195
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCE family.
messages: Component of the multifactor complex (MFC) composed of at least RLI1, the eIF2 subunit SUI2, TIF5/eIF5, and the eIF3 subunits PRT1, HCR1, NIP1, RPG1, TIF34 and TIF35. The complex associates with pre-initiation complexes. Interacts with the complex YAE1:LTO1; the complex bridges the interaction between the CIA complex and RLI1 (PubMed:23318452).
messages: Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.
messages: Cytoplasm
messages: Nucleus
messages: Present with 6280 molecules/cell in log phase SD medium.

559292:YIL176C
gene id: 559292:YIL176C
uniprot id: P0CE88
uniprot id: P0CE89
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YLR297W
gene id: 559292:YLR297W
uniprot id: Q05899
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: By the genotoxic agents methyl methanesulfonate (MMS), bleomycin and cisplatin.
messages: Present with 922 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YOR181W
gene id: 559292:YOR181W
uniprot id: Q12446
names: Miscellaneous
names: Subunit
messages: Interacts with KRE6, LSB3, LSB5 and YSC84.
messages: Present with 8580 molecules/cell in log phase SD medium.

559292:YNL160W
gene id: 559292:YNL160W
uniprot id: P38616
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Extensively N-glycosylated.
messages: In response to nutrient limitation. Repressed by high glucose concentrations.
messages: May be involved in cellular adaptations prior to stationary phase.
messages: Secreted
messages: To yeast sporulation-specific protein SPS100.

559292:YOR179C
gene id: 559292:YOR179C
uniprot id: Q08553
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of at least PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation, including snoRNAs and snRNAs.
messages: Nucleus
messages: Present with 1430 molecules/cell in log phase SD medium.

559292:YJL060W
gene id: 559292:YJL060W
uniprot id: P47039
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA).
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Present with 1600 molecules/cell in log phase SD medium.

559292:YMR168C
gene id: 559292:YMR168C
uniprot id: P40969
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters.
messages: Component of the CBF3 copmplex, which is formed of CBF3A/CBF2, CBF3B/CEP3, CBF3C/CTF13 and CBF3D.
messages: Nucleus
messages: Present with 1900 molecules/cell in log phase SD medium.
messages: centromere

559292:YKR102W
gene id: 559292:YKR102W
uniprot id: P36170
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flocculin family.
messages: Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, glucose, maltose and sucrose. Also involved in cell-substrate adhesion, haploid invasive growth and diploid pseudohyphae formation.
messages: Extensively O-glycosylated.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains. There is a linear correlation between protein size and the extend of adhesion: the more repeats, the stronger the adhesion properties and the greater the fraction of flocculating cells (By similarity).
messages: cell wall

559292:YLR415C
gene id: 559292:YLR415C
uniprot id: O13578
names: Subcellular Location Annotation
messages: Mitochondrion

559292:YER102W
gene id: 559292:YER102W
uniprot id: P0CX39
uniprot id: P0CX40
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 14400 molecules/cell in log phase SD medium.
messages: Present with 15900 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS8 in yeast.

559292:YOL042W
gene id: 559292:YOL042W
uniprot id: Q08213
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Mitochondrion
messages: Present with 3480 molecules/cell in log phase SD medium.

559292:YKL161C
gene id: 559292:YKL161C
uniprot id: P36005
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Accumulates in large amounts when cell wall integrity is compromised.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with RLM1.
messages: Serine/threonine-protein kinase involved in the SLT2 mitogen-activated (MAP) kinase signaling pathway that regulates cell wall integrity. May also be involved in the mating pheromone and the CWI MAPK pathways.

559292:YFL027C
gene id: 559292:YFL027C
uniprot id: P43570
names: Miscellaneous
messages: Present with 573 molecules/cell in log phase SD medium.

559292:YAR008W
gene id: 559292:YAR008W
uniprot id: P39707
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.
messages: Endomembrane system
messages: Heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN15.
messages: Mitochondrion outer membrane
messages: Nucleus
messages: The tRNA splicing endonuclease complex is present with 100 molecules/cell.

559292:YPL188W
gene id: 559292:YPL188W
uniprot id: Q06892
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Mitochondrion matrix
messages: Phosphorylates both NADH and NAD(+), with a twofold preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH.
messages: Present with 4650 molecules/cell in log phase SD medium.

559292:YML115C
gene id: 559292:YML115C
uniprot id: P23642
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANP1/MMN9/VAN1 family.
messages: Component of the M-Pol I complex which contains MNN9 and VAN1.
messages: Endoplasmic reticulum membrane
messages: Glycosylated.
messages: Golgi apparatus membrane
messages: Involved in regulation of the phosphorylation of a number of proteins, some of which appear to be important in cell growth control.
messages: Present with 4750 molecules/cell in log phase SD medium.
messages: The M-Pol I complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.

559292:YDR469W
gene id: 559292:YDR469W
uniprot id: Q03323
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dpy-30 family.
messages: Component of the COMPASS (Set1C) complex which consists of SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and SWD3(1).
messages: Nucleus
messages: Present with 937 molecules/cell in log phase SD medium.
messages: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance.

559292:YPL127C
gene id: 559292:YPL127C
uniprot id: P53551
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Could act as an H1-type linker histone. Has been shown to bind DNA.
messages: Nucleus
messages: Present with 6560 molecules/cell in log phase SD medium.

559292:YDL044C
gene id: 559292:YDL044C
uniprot id: P10849
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion matrix
messages: Present with 2060 molecules/cell in log phase SD medium.
messages: Required for the processing and/or for the stability of the CYTB and COX1 intron-containing pre-mRNAs and of the ATP6 transcript. Could be a stem-loop RNA-binding protein that plays a role in determining RNA stability.

559292:YGR216C
gene id: 559292:YGR216C
uniprot id: P53306
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGQ family.
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

559292:YHL019C
gene id: 559292:YHL019C
uniprot id: P38700
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the AP-1-related (AP-1R) complex, an adapter protein complex that mediates of cargo protein sorting in clathrin-coated vesicles (PubMed:26658609). AP-1R has a specific role in SNARE SNC1 sorting (PubMed:26658609). In contrast to the APM1-containing AP-1 complex, AP-1R is incapable of sorting CHS3 (PubMed:26658609).
messages: Component of the AP-1R complex composed of at least APM2, APL4 and APS1 (PubMed:26658609). Interacts with MIL1 (PubMed:26658609). Interacts with APL2 (PubMed:10564262).
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Leads to sensitivity to cationic amphiphilic drugs (CADs) such as sertraline.
messages: Present with 2890 molecules/cell in log phase SD medium.
messages: clathrin-coated vesicle membrane

559292:YGL183C
gene id: 559292:YGL183C
uniprot id: P53102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MND1 family.
messages: Heterodimer with HOP2. MND1-HOP2 binds preferentially to dsDNA.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates DMC1-dependent homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

559292:YFR019W
gene id: 559292:YFR019W
uniprot id: P34756
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Activated by VAC14 and VAC7. VAC14 acts as a specific osmotic response regulator.
messages: Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold.
messages: Endosome membrane
messages: Present with 149 molecules/cell in log phase SD medium.
messages: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate (PubMed:16492811, PubMed:9811604). Required for endocytic-vacuolar pathway and nuclear migration (PubMed:9751732, PubMed:16492811, PubMed:9811604). The product of the reaction, PI(3,5)P2 is an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole (PubMed:9811604, PubMed:9763421). PI(3,5)P2 regulates the transition between trans-SNARE complex formation and vacuole membrane fusion (PubMed:30427760). Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4 (PubMed:16492811).
messages: The chaperone-containing TCP1 (CCT) domain is essential for the interaction with the scaffold protein VAC14.
messages: The conserved cysteine-rich (CCR) domain contacts intramolecularly the C-terminus, including the kinase domain, and this interaction negatively regulates PI(3) 5-kinase activity.
messages: Vacuole membrane

559292:YHR181W
gene id: 559292:YHR181W
uniprot id: P38869
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SVP26 family.
messages: Interacts with itself. Interacts with KTR3, MNN2 and MNN5.
messages: N-glycosylated.
messages: Plays a role in retention of a subset of membrane proteins in the early Golgi compartments. Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5.
messages: Present with 1810 molecules/cell in log phase SD medium.
messages: cis-Golgi network membrane

559292:YDR437W
gene id: 559292:YDR437W
uniprot id: Q04082
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI19 family.
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1 (Probable). Interacts with GPI2 (PubMed:16278447).
messages: Endoplasmic reticulum membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Involved in cell wall biosynthesis.
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YBR014C
gene id: 559292:YBR014C
uniprot id: P38068
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

559292:YMR170C
gene id: 559292:YMR170C
uniprot id: P47771
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: Cytoplasm
messages: Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Required for pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis.
messages: Expression is under the control of MSN2 and MSN4, and is induced during diauxic shift and osmotic stress.
messages: Present with 2070 molecules/cell in log phase SD medium.

559292:YPR159C-A
gene id: 559292:YPR159C-A
uniprot id: Q8TGQ7
names: Subcellular Location Annotation
messages: Membrane

559292:YDR395W
gene id: 559292:YDR395W
uniprot id: Q04175
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the nucleopore complex. Interacts with LHP1, PAB1, RPL11, RPL16, RPL25, RPL31A in order to import them into the nucleus. Interacts also with the nucleopore complex proteins (nucleoporins) NSP1, NUP1, NUP116 and NUP159.
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of ribosomal proteins (RPL11, RPL16, RPL25, RPL31A), the poly(A)-binding protein PAB1, the HO endonuclease or the tRNA and snRNA chaperone LHP1. Indirectly involved in nuclear mRNA export through its PAB1 nuclear import activity.
messages: Present with 16300 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YNL077W
gene id: 559292:YNL077W
uniprot id: P53940
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Putative chaperone involved in protein folding. Interferes with propagation of [PSI+] prion when overproduced.

559292:YGR211W
gene id: 559292:YGR211W
uniprot id: P53303
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZPR1 family.
messages: Binds to the elongation factor 1-alpha.
messages: Cytoplasm
messages: Nucleus
messages: Present with 39900 molecules/cell in log phase SD medium.

559292:YBL003C
gene id: 559292:YBL003C
uniprot id: P04912
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1, a component of the NuA4 histone acetyltransferase (HAT) complex, to form H2AK4ac and H2AK7ac.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-106 (H2AQ105me) by NOP1 is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
messages: In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.
messages: N-acetylated by NAT4.
messages: Nucleus
messages: Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A interacts with ARP4, a shared component of the NuA4 histone acetyltransferase complex and the INO80 and SWR1 chromatin remodeling complexes, and serves to recruit first NuA4, mediating histone H4 acetylation, and subsequently the INO80/SWR1 complexes, facilitating DNA resection, to DSB sites. Gamma-H2A is required for sequestering cohesin around the break site, which is important for efficient post-replicative double-strand break repair by homologous recombination, holding the damaged chromatid close to its undamaged sister template. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated by PPH3, a component of the histone H2A phosphatase complex (HTP-C). Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.
messages: Present with 32100 molecules/cell in log phase SD medium.
messages: Sumoylated to from H2AK126su. May lead to transcriptional repression.
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with NAP1.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-5; H2AK7ac = acetylated Lys-8; H2AK126su = sumoylated Lys-127; H2AS128ph = phosphorylated Ser-129.

559292:YML095C
gene id: 559292:YML095C
uniprot id: P06838
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Component of the nucleotide excision repair factor 1 (NEF1) complex consisting of RAD1, RAD10 and RAD14. Interacts with SAW1.
messages: Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD1 forms an endonuclease that specifically degrades single-stranded DNA.
messages: Nucleus

559292:YML088W
gene id: 559292:YML088W
uniprot id: Q04511
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts with SKP1. Component of the probable SCF(UFO1) complex containing CDC53, SKP1, RBX1 and UFO1.
messages: Present with 639 molecules/cell in log phase SD medium.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).

559292:YPR073C
gene id: 559292:YPR073C
uniprot id: P40347
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm
messages: Present with 3500 molecules/cell in log phase SD medium.

559292:YHL001W
gene id: 559292:YHL001W
uniprot id: P38754
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL14 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 35100 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL14 in yeast.

559292:YGL106W
gene id: 559292:YGL106W
uniprot id: P53141
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Bud tip
messages: Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.
messages: Interacts with MYO1, MYO2 and IQG1 by binding to their IQ domains. Interacts with SEC4.

559292:YNL210W
gene id: 559292:YNL210W
uniprot id: P16523
names: Developmental Stage
names: Function
names: Induction
messages: Its expression is meiotically induced and required the IME1 protein.
messages: MER1 is synthesized only during meiosis.
messages: Required for chromosome pairing and genetic recombination. MER1 may function to bring the axial elements of the synaptonemal complex corresponding to homologous chromosomes together by initiating recombination. MER1 might be responsible for regulating the MER2 gene and/or gene product.

559292:YBR005W
gene id: 559292:YBR005W
uniprot id: P38212
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with PMT4 and WW domain of RSP5.
messages: Regulates chitin deposition in the cell wall.
messages: The PY motif is recognized directly by the WW domains of RSP5.
messages: Transmembrane domain is required, and the cytoplasmic region conserved between RCR1 and RCR2 is also essential, to endow resistance to Congo red.

559292:YOL059W
gene id: 559292:YOL059W
uniprot id: P41911
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: By anaerobic growth conditions and other conditions leading to accumulation of cytosolic NADH.
messages: Catalyzes the production of glycerol under anaerobic growth conditions. Glycerol production serves as a redox sink by consuming the excess cytosolic NADH during anaerobic metabolism.
messages: Cytoplasm
messages: It is uncertain whether Met-1 or Met-49 is the initiator.
messages: Leads to poor growth under anaerobic conditions (PubMed:9171333). Does not produce detectable glycerol, is highly osmosensitive and fails to grow under anoxic conditions, when GPD1 is also deleted (PubMed:9171333).
messages: Mitochondrion
messages: Present with 8966 molecules/cell in log phase SD medium.

559292:YLR446W
gene id: 559292:YLR446W
uniprot id: Q06204
names: Function
names: Similarity
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.

559292:YDR375C
gene id: 559292:YDR375C
uniprot id: P32839
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Essential for the expression of the Rieske iron-sulfur protein.
messages: Mitochondrion inner membrane
messages: Present with 1990 molecules/cell in log phase SD medium.

559292:YER011W
gene id: 559292:YER011W
uniprot id: P10863
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall. Required for anaerobic growth.
messages: Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from a specific glutamine within the PIR1/2/3 repeat, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
messages: Induced during anaerobic growth and by cold shock and glucose.
messages: Membrane
messages: O-glycosylated.
messages: Present with 623 molecules/cell in log phase SD medium.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
messages: cell wall

559292:YBR289W
gene id: 559292:YBR289W
uniprot id: P18480
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Nucleus
messages: Present with 217 molecules/cell in log phase SD medium.

559292:YGR082W
gene id: 559292:YGR082W
uniprot id: P35180
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom20 family.
messages: Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). In the complex, interacts with TOM22.
messages: Mitochondrion outer membrane
messages: Present with 5680 molecules/cell in log phase SD medium.

559292:YIL123W
gene id: 559292:YIL123W
uniprot id: P40472
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUN family.
messages: Expression is repressed by anoxia. Expression is decreased during transition to slow growing or stationary phases.
messages: Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions. Required for the maintenance of the CLB5 kinase activity.
messages: Leads to increased resistance to zymolyase treatment.
messages: Present with 1800 molecules/cell in log phase SD medium.
messages: cell wall

559292:YBL016W
gene id: 559292:YBL016W
uniprot id: P16892
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by tyrosine and threonine phosphorylation after pheromone treatment.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-180 and Tyr-182 by STE7 in response to pheromone induction, which activates the enzyme. Activated FUS3 initiates a feedback signal, down-regulating phosphorylation of both, FUS3 and KSS1.
messages: In the nucleus, FUS3 forms a complex with DIG1, DIG2 and STE12. The interaction of FUS3 with STE12 depends on the presence of both DIG1 and DIG2. STE12 is lost from FUS3/DIG1/DIG2 complex after pheromone treatment. During its activation and phosphorylation, FUS3 forms a membrane-associated complex with the scaffold protein STE5, the MAPKK STE7, the MAPKKK STE11, and the G-protein beta subunit GBB/STE4; interacting directly with STE7 and STE5.
messages: Nucleus
messages: Periplasm
messages: Present with 8480 molecules/cell in log phase SD medium.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
messages: Together with closely related KSS1, FUS3 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively. Phosphorylated FUS3 activates the mating but suppresses the filamentation pathway, whereas activated KSS1 activates both pathways. Pheromone-activated FUS3 functions by inhibiting the binding of the transcriptional activator STE12 to filamentation specific genes while inducing its binding to and activity at mating specific genes. Non-activated FUS3 has a repressive effect on STE12 transcriptional activity. KSS1 can partially compensate for the lack of FUS3 but mating efficiency is reduced and the filamentation program is partially activated upon pheromone signaling. FUS3 phosphorylates STE7, STE5, FAR1, DIG1, DIG2 and STE12.

559292:YBL112C
gene id: 559292:YBL112C
uniprot id: A0A023PXF5
uniprot id: Q3E7Y4
names: Caution
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Could be the product of a pseudogene unlikely to encode a functional protein. Although strongly related to DNA helicases, it lacks the helicase ATP-binding domains, suggesting that it has no helicase activity. Because of that it is not part of the S.cerevisiae S288c complete/reference proteome set.
messages: Could be the product of a pseudogene. Although strongly related to DNA helicases, it lacks the helicase ATP-binding domains, suggesting that it has no helicase activity.
messages: Upon SUB2 overexpression.

559292:YPL141C
gene id: 559292:YPL141C
uniprot id: Q03002
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Interacts with FAA3, POL5 and TPA1.
messages: Present with 556 molecules/cell in log phase SD medium.
messages: Putative serine/threonine-protein kinase that may be involved in rRNA transcription and ribosome biogenesis.

559292:YBR039W
gene id: 559292:YBR039W
uniprot id: P38077
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 28100 molecules/cell in log phase SD medium.
messages: PubMed:12898710 reports two tandemly repeated copies of ATP3 (ATP3a and ATP3b) on the right arm of chromosome II in several laboratory strains, including S288c. This has not been confirmed by the yeast genome sequencing project.

559292:YKL154W
gene id: 559292:YKL154W
uniprot id: P36057
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP receptor beta subunit family.
messages: Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity).
messages: Endoplasmic reticulum membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Present with 8250 molecules/cell in log phase SD medium.

559292:YMR040W
gene id: 559292:YMR040W
uniprot id: Q04210
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

559292:YLR099C
gene id: 559292:YLR099C
uniprot id: Q12385
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
messages: Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
messages: The isooctane tolerance of organic-solvent tolerant strain KK-21 may result from the alteration of the expression of several genes including ICT1, due to the loss of their proper regulation.

559292:YBR120C
gene id: 559292:YBR120C
uniprot id: P07253
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Present with 2130 molecules/cell in log phase SD medium.
messages: This protein is involved in processing of the 5' terminus and the intervening sequences of cytochrome b pre-mRNA.

559292:YKL188C
gene id: 559292:YKL188C
uniprot id: P34230
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Forms a heterodimer with PXA1.
messages: Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix.
messages: Peroxisome membrane

559292:YDR009W
gene id: 559292:YDR009W
uniprot id: P13045
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Present with 721 molecules/cell in log phase SD medium.
messages: The GAL3 gene is a member of the family of galactose inducible, glucose-repressible genes (which include GAL1, GAL2, GAL7, GAL10, GAL80, and MELI).
messages: The GAL3 regulatory function is required for rapid induction of the galactose system. At normal induction, galactose in the presence of the GAL3 protein may lead to the induction of the GAL genes, including GAL1. Then the galactokinase protein (GAL1) in the presence of galactose may reinforce the induction leading to a higher expression level. Upon depletion of galactose, the inducing activity of the galactokinase protein may decrease, after which transcription of the GAL genes, including GAL1, may decrease.

559292:YLR078C
gene id: 559292:YLR078C
uniprot id: P25385
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BOS1 family.
messages: Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with YIF1 and YIP1.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.

559292:YDR267C
gene id: 559292:YDR267C
uniprot id: Q05583
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Cytoplasm
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
messages: Interacts with NAR1.
messages: Nucleus
messages: Present with 5640 molecules/cell in log phase SD medium.

559292:YMR274C
gene id: 559292:YMR274C
uniprot id: Q03530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins, including the a-factor mating pheromone and RAS.

559292:YGL079W
gene id: 559292:YGL079W
uniprot id: P53158
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KXD1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Endosome
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YER185W
gene id: 559292:YER185W
uniprot id: P40100
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.
messages: By oxygen and heme deficiency.
messages: Cell membrane
messages: Involved in inducible protoporphyrin IX influx and heme efflux.
messages: N-glycosylated.

559292:YOR206W
gene id: 559292:YOR206W
uniprot id: P39744
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOC2 family.
messages: Interacts with MAK21/NOC1 and NOC3. Forms a nucleolar complex with MAK21 that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with NOC3 that binds to 66S pre-ribosomes.
messages: Involved in the intranuclear transport of ribosomal precursors.
messages: Present with 29000 molecules/cell in log phase SD medium.
messages: Was originally thought to be RAD4.
messages: nucleolus

559292:YLR307W
gene id: 559292:YLR307W
uniprot id: Q06702
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide deacetylase family.
messages: Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate (PubMed:9133736). Chitosan is a component of the spore wall (PubMed:9133736).
messages: Induced during sporulation.
messages: Prospore

559292:YPR118W
gene id: 559292:YPR118W
uniprot id: Q06489
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YHR098C
gene id: 559292:YHR098C
uniprot id: P38810
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII is composed of at least five proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Binds to SED5. Interacts with GHR1.
messages: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Present with 12200 molecules/cell in log phase SD medium.

559292:YKL155C
gene id: 559292:YKL155C
uniprot id: P36056
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although reported constituent of the mitochondrial small ribosomal subunit (PubMed:11278769), it has not been identified in the structure of the yeast mitoribosome (PubMed:28154081), indicating that RSM22 only transiently interacts with the mitoribosome.
messages: Associates with mitochondrial ribosomes.
messages: Belongs to the methyltransferase superfamily. Rsm22 family.
messages: Mitochondrion
messages: Present with 1900 molecules/cell in log phase SD medium.
messages: Probable S-adenosyl-L-methionine-dependent RNA methyltransferase (PubMed:19351663, PubMed:24651469). May provide the activity for methylation of the rRNA of the small mitochondrial subunit, which is required for the assembly and stability of the mitochondrial ribosome (PubMed:22689777). Has no protein methyltransferase activity (PubMed:24651469).

559292:YIL106W
gene id: 559292:YIL106W
uniprot id: P40484
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOB1/phocein family.
messages: Bud neck
messages: Cytoplasm
messages: Functions as an activator subunit for the DBF2 protein kinase. Binds to DBF2, which is required for the phosphorylation and activation of DBF2 by the upstream kinase CDC15 in late anaphase. DBF2-MOB1 is part of the mitotic exit network (MEN) signaling cascade, which regulates release from the nucleus and activity of phosphatase CDC14. Required for inactivation of mitotic cyclin-dependent kinase for exit from mitosis, cytokinesis and G1 gene transcription.
messages: Interacts with protein kinase DBF2 to form the MEN DBF2-MOB1 kinase complex.
messages: Nucleus
messages: Phosphorylated by CDC15.
messages: Present with 5020 molecules/cell in log phase SD medium.
messages: centromere
messages: spindle pole body

559292:YDL191W
gene id: 559292:YDL191W
uniprot id: P0CX84
uniprot id: P0CX85
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL29 is associated with the polypeptide exit tunnel (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 19100 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL29 in yeast.

559292:YJR068W
gene id: 559292:YJR068W
uniprot id: P40348
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair. RFC2 binds ATP and single-stranded DNA.
messages: Nucleus
messages: Present with 4610 molecules/cell in log phase SD medium.
messages: Replication factor C (RFC) is a heteropentamer of subunits RFC1, RFC2, RFC3, RFC4 and RFC5 and forms a complex with POL30/PCNA in the presence of ATP. Component of the RAD24-RFC complex which consists of RAD14, RFC2, RFC3, RFC4 and RFC5 and associates with the checkpoint clamp DDC1:MEC3:RAD17 complex. Component of the ELG1-RFC complex which consists of ELG1, RFC2, RFC3, RFC4 and RFC5. Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. RFC2 interacts with ECO1.

559292:YJL191W
gene id: 559292:YJL191W
uniprot id: P39516
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS11 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uS11 interacts with eS1 forming part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102). uS11 interacts with snoRNA U3. uS11 interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).
messages: Cytoplasm
messages: Present with 3370 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS11 in yeast.
messages: nucleolus

559292:YGL114W
gene id: 559292:YGL114W
uniprot id: P53134
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

559292:YER113C
gene id: 559292:YER113C
uniprot id: P40071
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Golgi apparatus membrane
messages: With EMP70 and TMN2, plays a critical role in the late stages of a nutrient-controlled pathway notably regulating FLO11 gene expression. Acts downstream of RAS2 and TOR. Essential for cell adhesion and filamentous growth. May play a role as effector of cellular copper homeostasis.

559292:YGR109W-A
gene id: 559292:YGR109W-A
uniprot id: Q12173
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.
messages: Cytoplasm
messages: Nucleocapsid protein p9 (NC) forms the nucleocore that coats the retro-elements dimeric RNA. Binds these RNAs through its zinc fingers (By similarity). Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty3 retrotransposons belong to the gypsy-like elements (metaviridae).
messages: The N-terminal domain of NC, but not its zinc finger, is required for nucleoprotein complex formation and its chaperone activities.

559292:YGR110W
gene id: 559292:YGR110W
uniprot id: P53264
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
messages: Expressed in aerobic conditions and under genotoxic stress (PubMed:10601195, PubMed:15878181). Expression is increased during respiratory growth and regulated by the heme activator protein transcriptional activation complex (PubMed:24318983).
messages: Mitochondrial cardiolipin-specific phospholipase which deacylates de novo synthesized cardiolipin (CL). Part of the remodeling process of cardiolipin, which involves deacylation-reacylation of premature cardiolipin. Has a strong substrate preference for palmitic acid residues and generates monolysocardiolipin (MLCL) for TAZ1-dependent reacylation with unsaturated fatty acids (PubMed:19244244, PubMed:23637464). The hydrolytic selectivity of the enzyme toward C16-CL substrates contributes to the preservation of C18:1-containing CL species (PubMed:27982579). Has high specificity towards peroxidized cardiolipids CL(OX). Required to mitigate oxidative stress by removing CL(OX) (PubMed:29935382).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Monomer.
messages: The HXXXXD motif is essential for acyltransferase activity.

559292:YIL063C
gene id: 559292:YIL063C
uniprot id: P40517
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Contains X-F-X-F-G repeats.
messages: Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.
messages: Interacts with GSP1, XPO1 and SRM1.
messages: Nucleus
messages: Present with 3620 molecules/cell in log phase SD medium.

559292:YDR120C
gene id: 559292:YDR120C
uniprot id: P15565
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs.
messages: Isoform 2 is N-acetylated by NatC at position 1. N-acetylation is necessary for targeting of the protein to the inner nuclear membrane.
messages: Mitochondrion
messages: Nucleus inner membrane
messages: Present with 15500 molecules/cell in log phase SD medium.

559292:YGL145W
gene id: 559292:YGL145W
uniprot id: P33891
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a peripheral membrane protein complex consisting of DSL1, SEC39/DSL3 and TIP20. Bound to a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6 through direct interaction of TIP20 with SEC20. Interacts with DSL1, SEC39/DSL3 and the cytoplasmic domain of SEC20.
messages: Endoplasmic reticulum membrane
messages: Present with 6020 molecules/cell in log phase SD medium.
messages: Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex.

559292:YBL099W
gene id: 559292:YBL099W
uniprot id: P07251
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
messages: Mitochondrion inner membrane
messages: Present with 41500 molecules/cell in log phase SD medium.

559292:YLR409C
gene id: 559292:YLR409C
uniprot id: Q06078
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with snoRNA U3. Interacts with MPP10. Interacts (via WD repeats) with UTP18. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: Present with 2020 molecules/cell in log phase SD medium.
messages: The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.
messages: nucleolus

559292:YKR090W
gene id: 559292:YKR090W
uniprot id: P36166
names: Miscellaneous
messages: Present with 1310 molecules/cell in log phase SD medium.

559292:YKL160W
gene id: 559292:YKL160W
uniprot id: P36053
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Present with 5860 molecules/cell in log phase SD medium.
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

559292:YJR095W
gene id: 559292:YJR095W
uniprot id: P33303
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: By ethanol or acetate as sole carbon sources. Repressed by glucose.
messages: Mitochondrion inner membrane
messages: Transports cytoplasmic succinate, derived from isocitrate by the action of isocitrate lyase in the cytosol, into the mitochondrial matrix in exchange for fumarate.

559292:YOR143C
gene id: 559292:YOR143C
uniprot id: P35202
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the thiamine pyrophosphokinase family.
messages: Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP).
messages: Expression requires the positive regulatory factors THI2 and THI3 (PubMed:8394343). Incompletely repressed by exogenous thiamine pyrophosphokinase (PubMed:8394343).
messages: Homodimer.
messages: Present with 3320 molecules/cell in log phase SD medium.

559292:YOR159C
gene id: 559292:YOR159C
uniprot id: Q12330
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the Sm core complex, present in spliceosomal snRNP U1, U2, U4/U6 and U5. The core complex contains SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively), and is probably a heptameric ring structure. SME1 specifically interacts with SMX2 and SMX3. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.
messages: Nucleus
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YPR170W-B
gene id: 559292:YPR170W-B
uniprot id: P0C5R9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:29526695). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:29526695).
messages: Endoplasmic reticulum membrane
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

559292:YDL024C
gene id: 559292:YDL024C
uniprot id: P52290
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

559292:YDR478W
gene id: 559292:YDR478W
uniprot id: P40993
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of RNase MRP complex which consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Essential component of the MRP ribonucleoprotein endoribonuclease that cleaves mitochondrial primer RNA sequences.
messages: Nucleus
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YDL115C
gene id: 559292:YDL115C
uniprot id: Q07532
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with RNA polymerase II. Part of a complex consisting of RPB1, RBP2, RPB3, RPB4, RPB5, RPB7, SPT5, DST1 and IWR1.
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import. Binds RNA polymerase II in the active center cleft between the two largest subunits in the cytoplasm. Then uses an N-terminal bipartite nuclear localization signal that may be recognized by karyopherin alpha to direct the polymerase II complex nuclear import. In the nucleus, is displaced from polymerase II complex by transcription initiation factors and nucleic acids, enabling its export and recycling.
messages: Due to the effects of deletion on gene expression, was originally thought to be a general transcription factor (PubMed:19679657). Further studies clearly suggest that it is involved in nuclear localization of the RNA polymerase II complex (PubMed:21504834).
messages: Leads to a K1 killer toxin hypersensitivity and pleiotropic effects on gene expression.
messages: Nucleus
messages: Present with 1080 molecules/cell in log phase SD medium.

559292:YNL033W
gene id: 559292:YNL033W
uniprot id: P53964
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Present with 396 molecules/cell in log phase SD medium.
messages: To yeast YNL019c.

559292:YPR163C
gene id: 559292:YPR163C
uniprot id: P34167
names: Function
names: Miscellaneous
messages: Involved in translation initiation. May be the homolog of mammalian eIF4B and be part of an RNA helicase. STM1/TIF3 is a non-essential gene.
messages: Present with 24000 molecules/cell in log phase SD medium.

559292:YLR082C
gene id: 559292:YLR082C
uniprot id: Q12020
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YKR094C
gene id: 559292:YKR094C
uniprot id: P0CH08
uniprot id: P0CH09
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2 (PubMed:23169626).
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: The 60S ribosomal protein L40 is present with 40000 molecules/cell in log phase SD medium.
messages: Ubiquitin is encoded by several different genes. UBI1 and UBI2 genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40. UBI3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. UBI4 is a polyprotein containing 5 exact head to tail repeats of ubiquitin.

559292:YLR381W
gene id: 559292:YLR381W
uniprot id: Q12748
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-I/CTF3 family.
messages: Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.
messages: Component of the heterotrimeric kinetochore subcomplex CTF3, which consists of CTF3, MCM16 and MCM22 (PubMed:11782448). The CTF3 subcomplex is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). Interacts with CTF19 (PubMed:11782448, PubMed:12589047). Interacts with CHL4 (PubMed:12589047).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Nucleus
messages: Present with 319 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YDL206W
gene id: 559292:YDL206W
uniprot id: Q12424
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane
messages: Putative cation exchanger.

559292:YHR067W
gene id: 559292:YHR067W
uniprot id: P38790
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HTD2 family.
messages: Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis. Required for respiratory growth and for normal mitochondrial morphology.
messages: Mitochondrion
messages: Present with 799 molecules/cell in log phase SD medium.

559292:YGL133W
gene id: 559292:YGL133W
uniprot id: P53125
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ISW2 complex, which at least consists of ISW2, ITC1, DLS1 and DPB4. May form a stable subcomplex with ISW2.
messages: Functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. ITC1 is required for nucleosome-stimulated ATPase activity and chromatin-remodeling activity of the complex. Required for the repression of MATa a-specific genes.
messages: Nucleus
messages: Present with 2610 molecules/cell in log phase SD medium.

559292:YNL100W
gene id: 559292:YNL100W
uniprot id: P50945
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.
messages: Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.
messages: Mitochondrion inner membrane

559292:YIR017C
gene id: 559292:YIR017C
uniprot id: P40573
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an accessory factor in the activation of sulfur amino acids metabolism genes. Possesses no intrinsic transcription activation abilities. Binds to the MET16 promoter as a complex with MET4 and CBF1. Enhances the DNA-binding activity of CBF1.
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Expression requires MET4, and is repressed by an increase of intracellular S-adenosylmethionine (AdoMet).
messages: Interacts with MET4 to form a heteromeric complex which also includes CBF1. Forms two alternate complexes associating MET28 with MET4 and either MET31 or MET32. Binds to DNA through the MET4-MET28-CBF1 complex.
messages: Nucleus

559292:YIL155C
gene id: 559292:YIL155C
uniprot id: P32191
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Present with 1670 molecules/cell in log phase SD medium.

559292:YHR061C
gene id: 559292:YHR061C
uniprot id: P38785
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BORG/CEP family.
messages: Bud neck
messages: Bud tip
messages: Interacts with GTP-bound CDC42.
messages: Present with 1100 molecules/cell in log phase SD medium.
messages: Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.
messages: cell cortex
messages: cytoskeleton

559292:YDR378C
gene id: 559292:YDR378C
uniprot id: Q06406
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. In association with PAT1, LSM1-LSM7 binds directly to RNAs near the 3'-end and prefers oligoadenylated RNAs over polyadenylated RNAs. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. Component of a nucleolar LSM2-LSM7 complex, which associates with the precursor of the RNA component of RNase P (pre-P RNA) and with the small nucleolar RNA (snoRNA) snR5. It may play a role in the maturation of a subset of nucleolus-associated small RNAs.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a doughnut shape. The LSm subunits are arranged in the order LSM1, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. Except for LSM1, where a C-terminal helix crosses the ring structure to form additional interactions with LSM3 and LSM6, each subunit interacts only with its two neighboring subunits. The LSM1-LSM7 complex interacts with PAT1; within the complex PAT1 has direct interactions with LSM2 and LSM3. LSM1-LSM7 associates also with PAT1 and XRN1. Component of the heptameric LSM2-LSM8 complex that forms a seven-membered ring structure with a doughnut shape; an RNA strand can pass through the hole in the center of the ring structure. The LSm subunits are arranged in the order LSM8, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. LSM2-LSM8 associates with PAT1 and XRN1. Component of a LSM2-LSM7 complex, which consists of at least LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. It is not known whether another protein replaces the missing LSm to form a novel heptameric complex. Component of the spliceosome U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: nucleolus

559292:YLR183C
gene id: 559292:YLR183C
uniprot id: Q06266
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLM2/TOS4 family.
messages: Binds to the promoters of genes with functions important for the G1/S (start) transition; primarily genes involved in pheromone response, polarized growth and transcription.
messages: Nucleus
messages: Phosphorylated by CDC28.
messages: Present with 284 molecules/cell in log phase SD medium.
messages: Regulated in a cell cycle-dependent manner, peaking in G1 phase. Appears exclusively during the G1 and S phases (at protein level). Negatively regulated by transcription factor SBF (SWI4-SWI6 cell-cycle box binding factor).

559292:YBR058C
gene id: 559292:YBR058C
uniprot id: P38237
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 3040 molecules/cell in log phase SD medium.
messages: Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616). Accelerates proteasomal breakdown of ubiquitinated proteins as it disassembles free ubiquitin chains that would compete with ubiquitinated proteins to bind to the proteasome (PubMed:9305625).

559292:YOL161C
gene id: 559292:YOL161C
uniprot id: Q08322
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Membrane

559292:YKR001C
gene id: 559292:YKR001C
uniprot id: P21576
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Essential for protein sorting in meiotic cell division of S.cerevisiae; it binds microtubules. Could also be involved in microtubule-associated motility. Necessary for membrane protein retention in a late Golgi compartment. Interacts with the MVP1 protein.
messages: Present with 5960 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YDR393W
gene id: 559292:YDR393W
uniprot id: Q04172
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE9 family.
messages: Homooligomer. Participates in a complex of about 300 kDa.
messages: Mitochondrion inner membrane
messages: Present with 279 molecules/cell in log phase SD medium.
messages: Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.

559292:YBL101C
gene id: 559292:YBL101C
uniprot id: P38167
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSR2 family.
messages: Cytoplasm
messages: May be involved in cell wall organization and biogenesis.
messages: Present with 799 molecules/cell in log phase SD medium.

559292:YNL284C-B
gene id: 559292:YNL284C-B
uniprot id: Q12112
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YNL284C-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YIL048W
gene id: 559292:YIL048W
uniprot id: P40527
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with MON2.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes.

559292:YDL028C
gene id: 559292:YDL028C
uniprot id: P54199
names: Function
names: PTM
names: Similarity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Implicated in spindle pole body (SPD) duplication. Dual specificity kinase that can phosphorylate serine, threonine and tyrosine residues. Phosphorylates the SPC29 and SPC110 spindle pole body components.

559292:YOL065C
gene id: 559292:YOL065C
uniprot id: Q08227
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Endoplasmic reticulum membrane
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: Regulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion. Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P).

559292:YGR140W
gene id: 559292:YGR140W
uniprot id: P32504
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters.
messages: Component of the CBF3 copmplex, which is formed of CBF3A/CBF2, CBF3B/CEP3, CBF3C/CTF13 and CBF3D. CBF2 strongly interacts with BIR1. Interacts with the central kinetochore protein CTF19.
messages: Nucleus
messages: Present with 1350 molecules/cell in log phase SD medium.
messages: centromere
messages: spindle pole body

559292:YEL007W
gene id: 559292:YEL007W
uniprot id: P40002
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIT1/WOR1 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1710 molecules/cell in log phase SD medium.
messages: Transcriptional regulator of pseudohyphal growth.

559292:YGL009C
gene id: 559292:YGL009C
uniprot id: P07264
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Monomer.
messages: Present with 96300 molecules/cell in log phase SD medium.

559292:YDL219W
gene id: 559292:YDL219W
uniprot id: Q07648
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 10-fold decrease in D-tyrosyl-tRNA(Tyr) deacylase activity, growth becomes more sensitive to D-tyrosine and is inhibited at 0.1 mM D-Tyr (PubMed:10766779, PubMed:10918062). Growth is also inhibited in the presence of 0.3 mM D-leucine; wild-type cells grow well in up to 0.3 mM D-Tyr and 10 mM D-Leu (PubMed:10918062). No growth differences observed in the presence of the other D-amino acids (PubMed:10918062).
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs (Probable). Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr) (PubMed:10766779). May also deacylate mischarged D-leucyl-tRNA(Leu) (PubMed:10918062). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity).
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.
messages: Present with 4610 molecules/cell in log phase SD medium.

559292:YAL038W
gene id: 559292:YAL038W
uniprot id: P00549
names: Activity Regulation
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.
messages: Present with 291000 molecules/cell in log phase SD medium.
messages: The activity is regulated by glucose levels. Activated by fructose-1,6-bisphosphate.

559292:YBR136W
gene id: 559292:YBR136W
uniprot id: P38111
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Induced during meiosis.
messages: Interacts with LCD1, which is required for localization MEC1 to the RPA complex. Interacts directly with the RPA subunits RFA1 and RFA2.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited in complex with protein LCD1 by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Phosphorylates LCD1 and RPA2, a subunit of RPA, involved in DNA replication, repair and recombination. Phosphorylates RAD9, CHK1 and RAD53, which leads to the activation of the CHK1 and RAD53 kinases involved in DNA damage repair cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are proteins involved in genome stability. Required for cell growth and meiotic recombination.

559292:YNL048W
gene id: 559292:YNL048W
uniprot id: P53954
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with ALG1.
messages: Present with 3140 molecules/cell in log phase SD medium.
messages: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.

559292:YBR175W
gene id: 559292:YBR175W
uniprot id: P38123
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the COMPASS (Set1C) complex which consists of SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and SWD3(1).
messages: Nucleus
messages: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: telomere

559292:YCL027W
gene id: 559292:YCL027W
uniprot id: P11710
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: FUS1 remains essentially unexpressed in vegetative cells, but is strongly induced by incubation of haploid cells with the appropriate mating pheromone.
messages: Interacts with SHO1.
messages: Membrane
messages: O-glycosylated.
messages: Required for cell fusion. Negatively regulates Sho1p signaling to ensure efficient cell fusion.

559292:YPL101W
gene id: 559292:YPL101W
uniprot id: Q02884
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP4 family.
messages: Component of the elongator complex which consists of ELP1/IKI3, ELP2, ELP3, ELP4, ELP5/IKI1 and ELP6 (PubMed:11435442, PubMed:11390369, PubMed:11689709, PubMed:27974378, PubMed:27872205). The elongator complex is composed of two copies of the Elp123 subcomplex (composed of ELP1/IKI3, ELP2 and ELP3) and two copies of the Elp456 subcomplex (composed of ELP4, ELP5/IKI1 and ELP6) (PubMed:27974378, PubMed:27872205). The Elp123 subcomplex forms a two-lobed scaffold, which binds the Elp456 subcomplex asymmetrically (PubMed:27974378, PubMed:27872205). In each lobe, ELP2 is tightly sandwiched between ELP1/IKI3 and ELP3 (PubMed:31309145). The Elp123 subcomplex binds tRNA through ELP1/IKI3 and ELP3 and can bind 2 tRNAs simultaneously (PubMed:31309145). tRNA-binding by the Elp123 subcomplex induces conformational rearrangements which precisely position the targeted anticodon base in the active site (PubMed:31309145). The Elp456 subcomplex binds tRNA and has ATPase activity (PubMed:22556426, PubMed:22343726). ELP4 interacts with KTI12 (PubMed:15772087).
messages: Component of the elongator complex, a multiprotein complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368).
messages: Cytoplasm
messages: Nucleus
messages: Present with 358 molecules/cell in log phase SD medium.
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

559292:YER037W
gene id: 559292:YER037W
uniprot id: P40025
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the SSM1 family.
messages: By low phosphate level.
messages: May be involved in phosphate metabolism.
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YDR304C
gene id: 559292:YDR304C
uniprot id: P35176
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
messages: Endoplasmic reticulum lumen
messages: Induced by ER stress caused by treatment with tunicamycin.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

559292:YGL095C
gene id: 559292:YGL095C
uniprot id: P38932
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Cytoplasm
messages: Essential for vacuolar protein sorting. Function in membrane traffic between the Golgi and the vacuole.
messages: Interacts with PEP7 and TLG2.
messages: Present with 5660 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YNL121C
gene id: 559292:YNL121C
uniprot id: P07213
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom70 family.
messages: Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.
messages: Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). In the complex interacts with TOM22. Interacts with TOM37.
messages: Mitochondrion outer membrane
messages: Present with 45300 molecules/cell in log phase SD medium.

559292:YOR386W
gene id: 559292:YOR386W
uniprot id: P05066
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) non-covalently per subunit.
messages: Binds 1 FAD per subunit.
messages: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus
messages: Present with 688 molecules/cell in log phase SD medium.
messages: There are only 150-300 molecules of photolyase per yeast cell.

559292:YDR044W
gene id: 559292:YDR044W
uniprot id: P11353
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
messages: Present with 22000 molecules/cell in log phase SD medium.

559292:YBL027W
gene id: 559292:YBL027W
uniprot id: P0CX82
uniprot id: P0CX83
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eL19 lies in close proximity to the binding site for eukaryotic initiation factor eIF4G (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL19 may play a role in the last stages of translation initiation, in particular subunit joining and shedding/releasing factors.
messages: Cytoplasm
messages: Present with 225000 molecules/cell in log phase SD medium.
messages: Present with 97700 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL19 in yeast.

559292:YGR083C
gene id: 559292:YGR083C
uniprot id: P12754
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as essential component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD2 is also required for cell viability. Its function can partially be replaced by GCN3 under normal growth conditions in GCD2-defective mutants, under AA starvation conditions GCN3 is an antagonist (GCN4 translational activator).
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Present with 10300 molecules/cell in log phase SD medium.
messages: Translation initiation factor 2B (eIF2-B) is composed of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6). A regulatory subcomplex comprising GCN3, GCD7 and GCD2 interacts preferentially with phosphorylated eIF-2 and has no exchange activity in vitro.

559292:YML034W
gene id: 559292:YML034W
uniprot id: Q03707
names: Function
names: Subcellular Location Annotation
messages: Nucleus inner membrane
messages: Plays a role in sister chromatid separation.

559292:YLR018C
gene id: 559292:YLR018C
uniprot id: Q12445
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.
messages: Nucleus membrane
messages: nuclear pore complex

559292:YDR339C
gene id: 559292:YDR339C
uniprot id: Q05498
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites.
messages: Interacts with FAF1.
messages: nucleolus

559292:YPL018W
gene id: 559292:YPL018W
uniprot id: Q02732
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-P/CTF19 family.
messages: Component of the heterotetrameric kinetochore subcomplex COMA, which consists of AME1, CTF19, MCM21 and OKP1 (PubMed:10323865, PubMed:14633972). The COMA subcomplex is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). COMA binds the centromeric nucleosome-binding protein MIF2, and to the outer kinetochore MIND subcomplex (By similarity). CTF19 interacts with the CTF3 complex subunits CTF3, MCM16 and MCM22 as well as CHL4 and IML3 (PubMed:11782448, PubMed:12589047). Interacts with the N-terminal domain of centromeric nucleosome protein CSE4 and with the CBF3 complex subunit A (CBF2) (PubMed:10958698).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Nucleus
messages: Present with 1254 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YFL055W
gene id: 559292:YFL055W
uniprot id: P43548
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: General amino acid permease with broad substrate specificity.
messages: Membrane

559292:YDR485C
gene id: 559292:YDR485C
uniprot id: Q03388
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWR1 complex at least composed of ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWR1 and HTZ1. Interacts with HTZ1.
messages: Belongs to the VPS72/YL1 family.
messages: Nucleus
messages: Participates in the catalytic exchange of histone H2A for the H2A variant HTZ1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes. Indirectly involved in vacuolar protein sorting.
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YOL013C
gene id: 559292:YOL013C
uniprot id: Q08109
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HRD1 family.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). In ERAD-L, facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with DER1 (PubMed:32327568). Both proteins have lateral gates facing each other which form a channel through the ER membrane and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1. ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M.
messages: Endoplasmic reticulum membrane
messages: Impaired degradation of proteins with misfolded intramembrane or lumenal domains.
messages: Monomer (PubMed:32327568). Has also been shown to form homodimers (PubMed:28682307). However, dimer assembly is likely to be non-physiological (PubMed:32327568). Forms homooligomers in a USA1-dependent manner (PubMed:20005842, PubMed:21074049). However, can function as a monomer in ERAD-L so the role of USA1-dependent oligomerization remains unclear (PubMed:32327568). Component of the HRD1 ubiquitin ligase complex which contains the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873066). Within the complex, interacts directly with HRD3 and USA1 and indirectly with DER1 (PubMed:11018054, PubMed:16619026, PubMed:20005842, PubMed:21074049, PubMed:28682307). In ERAD-L, HRD3 and YOS9 jointly bind misfolded glycoproteins in the endoplasmic reticulum (ER) lumen (PubMed:32327568). Movement of ERAD-L substrates through the ER membrane is facilitated by HRD1 and DER1 which have lateral gates facing each other and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568). The HRD1 complex interacts with the heterotrimeric CDC48-NPL4-UFD1 ATPase complex which is recruited by UBX2 via its interaction with CDC48 and which moves ubiquitinated substrates to the cytosol for targeting to the proteasome (PubMed:16873066, PubMed:16619026). The HRD1 complex interacts with the ERAD substrates HMG1 and HMG2 (PubMed:11390656). Interacts with the associated E2 ubiquitin conjugating enzymes UBC1 and UBC7 with its membrane anchor CUE1 (PubMed:11146622).
messages: Present with 2660 molecules/cell in log phase SD medium.

559292:YGR279C
gene id: 559292:YGR279C
uniprot id: P53334
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.
messages: N-glycosylated.
messages: Present with 38000 wall-bound molecules/cell in log phase YPD medium.
messages: cell wall

559292:YJR160C
gene id: 559292:YJR160C
uniprot id: P0CE00
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: By maltose and maltotriose. Repressed by glucose.
messages: Cell membrane
messages: High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose.

559292:YNL178W
gene id: 559292:YNL178W
uniprot id: P05750
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 146000 molecules/cell in log phase SD medium.
messages: Ubiquitinated at 'Lys-212' by HEL2/UBC4.

559292:YGR218W
gene id: 559292:YGR218W
uniprot id: P30822
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the exportin family.
messages: Interacts with GSP1/GSP2, polyadenylate-binding protein PAB1 and PRP40.
messages: Nucleus
messages: Present with 7080 molecules/cell in log phase SD medium.
messages: Receptor for the leucine-rich nuclear export signal (NES).
messages: perinuclear region

559292:YHR210C
gene id: 559292:YHR210C
uniprot id: P38893
names: Similarity
messages: Belongs to the aldose epimerase family.

559292:YDL056W
gene id: 559292:YDL056W
uniprot id: P39678
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.
messages: Component of the transcription complex MCB-binding factor (MBF) composed of SWI6 and MBP1. Interacts with MSA1.
messages: Nucleus
messages: Present with 521 molecules/cell in log phase SD medium.

559292:YGR161W-B
gene id: 559292:YGR161W-B
uniprot id: P0CX63
uniprot id: P0CX64
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YFL002W-B ORF.
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YGR161W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YDR314C
gene id: 559292:YDR314C
uniprot id: Q06665
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Involved in nucleotide excision repair (NER) of damaged ribosomal DNA (rDNA). Required for the repair of the RNA polymerase I-transcribed strand of rDNA.
messages: Nucleus
messages: Present with 78 molecules/cell in log phase SD medium.

559292:YIL036W
gene id: 559292:YIL036W
uniprot id: P40535
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus
messages: Present with 1240 molecules/cell in log phase SD medium.
messages: Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources.

559292:YLR324W
gene id: 559292:YLR324W
uniprot id: Q06169
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEX28-32 family. PEX30/31 subfamily.
messages: Peroxisome membrane

559292:YNL119W
gene id: 559292:YNL119W
uniprot id: P53923
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Interacts with NCS6 and URM1. May act by forming a heterodimer with NCS6.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation and in invasive and pseudohyphal growth. Inhibits replication of Brome mosaic virus.
messages: Present with 2860 molecules/cell in log phase SD medium.

559292:YJL044C
gene id: 559292:YJL044C
uniprot id: P32806
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 2990 molecules/cell in log phase SD medium.
messages: Stimulates specifically the GTPase activity of YPT6.

559292:YPL165C
gene id: 559292:YPL165C
uniprot id: Q12529
names: Function
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in resistance to compounds that target ergosterol biosynthesis, including fenpropimorph, dyclonine, and alverine citrate. Since a deletion in the absence of these compounds does not have an effect on growth, is more likely to be involved in compound availability.

559292:YMR272C
gene id: 559292:YMR272C
uniprot id: Q03529
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Causes a lack of alpha-hydroxylated very long chain fatty acids in yeast sphingolipids. This confers resistance to syringomycin E, an antifungal cyclic lipodepsinonapeptide produced by Pseudomonas syringae.
messages: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids (PubMed:9353282, PubMed:9368039, PubMed:26977056, PubMed:9559540, PubMed:16652392, PubMed:19074599). Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2 (PubMed:9368039, PubMed:26977056).
messages: Endoplasmic reticulum membrane
messages: Present with 3290 molecules/cell in log phase SD medium.
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

559292:YNL332W
gene id: 559292:YNL332W
uniprot id: P42883
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

559292:YFL018C
gene id: 559292:YFL018C
uniprot id: P09624
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: LPD1 is a homodimer. Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds. LPD1 is a component of the glycine decarboxylase complex (GDC), which is composed of four proteins: P, T, L and H.
messages: Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine.
messages: Mitochondrion matrix
messages: Present with 24600 molecules/cell in log phase SD medium.
messages: The active site is a redox-active disulfide bond.

559292:YPL072W
gene id: 559292:YPL072W
uniprot id: Q02863
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YLL051C
gene id: 559292:YLL051C
uniprot id: Q12473
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: By transcription factor AFT2 upon iron deprivation.
messages: Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol.
messages: Vacuole membrane

559292:YDR293C
gene id: 559292:YDR293C
uniprot id: P24276
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the RNR ribonuclease family.
messages: Can suppress the lethality due to deletion of SIT4, and partially the defects due to BCY1 disruption. Is implicated in the control of the cell cycle G1 phase.
messages: Present with 1100 molecules/cell in log phase SD medium.
messages: Several alleles of SSD1 exist in different yeast strains.

559292:YAR050W
gene id: 559292:YAR050W
uniprot id: P32768
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flocculin family.
messages: Cell membrane
messages: Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Also involved in cell-substrate adhesion.
messages: Extensively N- and O-glycosylated.
messages: For many industrial applications in which the yeast S.cerevisiae is used, e.g. beer, wine and alcohol production, appropriate flocculation behavior is one of the most important characteristics of a good production strain. The ability of yeast cells to flocculate is of considerable importance, as it provides an effective, environment-friendly, simple and cost-free way to separate yeast cells from the fermentation product at the end of fermentation.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains. There is a linear correlation between protein size and the extend of adhesion: the more repeats, the stronger the adhesion properties and the greater the fraction of flocculating cells. The Ser/Thr-rich repeats are also important for proper cell wall targeting of the protein.
messages: cell wall

559292:YER175C
gene id: 559292:YER175C
uniprot id: P32643
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. Tam family.
messages: Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation.
messages: Cytoplasm
messages: During amino acid starvation.
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YHR186C
gene id: 559292:YHR186C
uniprot id: P38873
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RAPTOR family.
messages: Cell membrane
messages: Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.
messages: The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B) (PubMed:12408816, PubMed:12631735, PubMed:16394584). Interacts with PIB2; following activation of PIB2 by glutamine or cysteine (PubMed:29698392). TORC1 binds to and is inhibited by FKBP-rapamycin (PubMed:12408816).
messages: Vacuole membrane

559292:YPL010W
gene id: 559292:YPL010W
uniprot id: P53600
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (PubMed:9058184). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (PubMed:9058184).

559292:YIL056W
gene id: 559292:YIL056W
uniprot id: P40522
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VHR1 family.
messages: By stress, probably through the induction by the transcription factor PDR1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 279 molecules/cell in log phase SD medium.
messages: Transcription factor that binds to the VHRE consensus sequence in promoters of VHT1 and BIO5, and regulates their biotin-dependent expression.

559292:YPR157W
gene id: 559292:YPR157W
uniprot id: Q06466
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS62 family.
messages: By 8-methoxypsoralen and UVA.
messages: Involved in vacuolar protein sorting.
messages: Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.
messages: Membrane

559292:YDR492W
gene id: 559292:YDR492W
uniprot id: Q03419
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.
messages: Belongs to the ADIPOR family.
messages: Endoplasmic reticulum membrane
messages: Expression is regulated by the zinc metabolism transcription factor ZAP1 via its promoter ZRE element (zinc-responsive element).

559292:YNL186W
gene id: 559292:YNL186W
uniprot id: P53874
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme involved in telomere and HM loci silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes (PubMed:9755194, PubMed:10490600, PubMed:14623890). Targets histone H2B for deubiquitination, thus helping to localize SIR2 to the telomere (PubMed:15721261, PubMed:17028327, PubMed:22056669). At silent chromatin, including telomeres and the rDNA locus, not only maintains low H2B 'Lys-123' ubiquitination (H2BK123Ub), but also low H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively) (PubMed:15721261, PubMed:15988024). Controls the proliferating-cell nuclear antigen PCNA/POL30 deubiquitination which is crucial for keeping TLS polymerases in check as well as for down-regulating the error-free bypass (PubMed:22829782). Deubiquitinates and stabilizes RPA190, the largest subunit of RNA polymerase I, to achieve optimal levels of ribosomes and cell growth (PubMed:22902402). Protects also nutrient transporters such as GAP1 from ubiquitin-dependent endocytosis (PubMed:11352638).
messages: Exhibits reduced silencing and a corresponding decrease in the level of SIR4 (PubMed:10490600). Reduces also the level of the low-affinity, high-capacity transporter of amino acids GAP1 (PubMed:11352638). Leads to alterations in expression of subtelomeric genes together with a broad change in the whole transcriptional profile, closely parallel to that induced by oxidative stress (PubMed:14623890). Results also in extrachromosomal rDNA circles (ERCs) accumulation (PubMed:17028327). Accumulates also mono- and di-ubiquitinated PCNA/POL30 in response to DNA damage and replicative stress (PubMed:22829782). Leads to reduced pre-rRNAs, mature rRNAs, and translating ribosomes (PubMed:22902402).
messages: Interacts with SIR4 (PubMed:10490600, PubMed:26149687). Interacts with the proliferating-cell nuclear antigen PCNA/POL30 (PubMed:22829782). Interacts with DHR2 and UTP22 (PubMed:22902402, PubMed:26149687).
messages: Nucleus
messages: Residues 109-145 within the N-terminal intrinsically disordered regions (IDR) constitute the binding module for SIR4 which required to coordinate the UBP10-SIR4 interaction, but also to direct UBP10's functional role in telomere chromatin silencing (PubMed:26149687).
messages: Residues 167-208 within the N-terminal intrinsically disordered regions (IDR) constitute the binding module for UTP22 which is required to coordinate the UBP10-UTP22 interaction (PubMed:26149687).
messages: Residues 2-27 within the N-terminal intrinsically disordered regions (IDR) constitute the binding module for DHR2 which is required to coordinate the UBP10-DHR2 interaction (PubMed:26149687).
messages: nucleolus
messages: telomere

559292:YML047C
gene id: 559292:YML047C
uniprot id: Q04705
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KCH1 low affinity K(+) transporter family.
messages: Bud tip
messages: Cell membrane
messages: Expression is strongly induced during the response to alpha-factor.
messages: Leads to high-affinity Ca(2+) influx system (HACS) deficiency (PubMed:21252230, PubMed:23204190). Causes a large increase of cell death in response to mating pheromone, when KCH1 is also deleted (PubMed:23204190).
messages: Low affinity potassium transporter that, with KCH1, participates in high-affinity Ca(2+) influx system (HACS) activation during the response to mating pheromone (PubMed:21252230, PubMed:23204190). Directly promotes K(+) influx and HACS may electrochemically respond to this K(+) influx (PubMed:23204190). KCH1 and PRM6/KCH2 act at the apex of the calcium signaling pathway that is used for survival during prolonged exposures to mating pheromones (PubMed:23204190).
messages: Vacuole lumen

559292:YGR036C
gene id: 559292:YGR036C
uniprot id: P53223
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Causes an elevation in dolichyl diphosphate levels.
messages: Endoplasmic reticulum membrane
messages: Non-essential protein which is required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

559292:YNR013C
gene id: 559292:YNR013C
uniprot id: P27514
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Expression is constitutive and independent of inorganic phosphate concentration and PHO4 activity.
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: Ubiquitinated by RSP5. RSP5-mediated ubiquitination initiates internalization and degradation by the endocytic pathway.
messages: Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol.
messages: Vacuole membrane

559292:YOL005C
gene id: 559292:YOL005C
uniprot id: P38902
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript termination.
messages: Nucleus
messages: Present with 4280 molecules/cell in log phase SD medium.

559292:YKL173W
gene id: 559292:YKL173W
uniprot id: P36048
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Interacts (via C-terminus) with CWC21. Interacts (via N-terminus) with PRP8 (via SCwid domain).
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.
messages: Nucleus
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YDR316W-A
gene id: 559292:YDR316W-A
uniprot id: P0CX65
uniprot id: P0CX66
uniprot id: P0CX67
uniprot id: P0CX68
uniprot id: P0CX69
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR5 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ER2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-GR3 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-MR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YBR017C
gene id: 559292:YBR017C
uniprot id: P38217
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family. Importin beta-2 subfamily.
messages: Binds to nucleoporin FxFG but not PSFG repeat regions.
messages: Cytoplasm
messages: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Required for nuclear transport of NAB2, HRP1/NAB4 and TFG2. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins (PubMed:8849456, PubMed:9488461, PubMed:10506153, PubMed:19366694). The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015). At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. Efficient GTP-Ran-mediated substrate release requires RNA (PubMed:10506153). The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015).
messages: Interacts with Ran (GSP1) (PubMed:9321403, PubMed:10506153); interacts specifically with the GTP-bound form of Ran (GTP-Ran), protecting it from GTP hydrolysis and nucleotide exchange (PubMed:9321403). Interacts with nucleoporins NUP1, NUP100 and NUP116 (PubMed:8849456). Interacts with NAB2 and HRP1/NAB4; via their rg-NLS (PubMed:9488461, PubMed:10506153). Interacts with TFG2; via its PY-NLS (PubMed:19366694).
messages: Nucleus
messages: Present with 2130 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YDL120W
gene id: 559292:YDL120W
uniprot id: Q07540
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the frataxin family.
messages: Mitochondrion matrix
messages: Monomer; increments in mitochondrial iron uptake induce stepwise assembly of species ranging from trimers to 24-mers. Interacts with ISU1. Interacts with YHB1, SDH1, SDH2, AIM45 and CIR1.
messages: Present with 1560 molecules/cell in log phase SD medium.
messages: Processed in two steps by mitochondrial processing peptidase (MPP). MPP first cleaves the precursor to intermediate form and subsequently converts the intermediate to mature size protein.
messages: Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.

559292:YDL226C
gene id: 559292:YDL226C
uniprot id: P35197
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein (GAP) for ARF1 and ARF2. Involved in intracellular vesicular transport. Required for transport from the trans-Golgi network. Implicated in the regulation of retrograde transport from the Golgi to the ER and in actin cytoskeletal organization. May be involved in the maintenance of mitochondrial morphology, possibly through organizing the actin cytoskeleton in Saccharomyces.
messages: Golgi apparatus
messages: Mitochondrion
messages: Present with 9560 molecules/cell in log phase SD medium.
messages: perinuclear region

559292:YJR135W-A
gene id: 559292:YJR135W-A
uniprot id: P57744
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins under precise conditions, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins. Strictly required for import of TIM23 in some conditions, when a low membrane potential exists in the mitochondria.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).

559292:YFR018C
gene id: 559292:YFR018C
uniprot id: P43599
names: Miscellaneous
messages: Present with 3970 molecules/cell in log phase SD medium.

559292:YHR069C
gene id: 559292:YHR069C
uniprot id: P38792
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure. Interacts with LRP1/RRP47.
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP4 as peripheral part of the Exo-9 complex is thought to stabilize the hexameric ring of RNase PH-domain subunits.
messages: Present with 4840 molecules/cell in log phase SD medium.
messages: Was originally (PubMed:9390555 and PubMed:8600032) thought to have exonuclease activity but it was later shown (PubMed:17173052 and PubMed:17174896) that only DIS3/RRP44 subunit of the exosome core has this activity.
messages: nucleolus

559292:YPR063C
gene id: 559292:YPR063C
uniprot id: Q12160
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 2140 molecules/cell in log phase SD medium.

559292:YKL033W
gene id: 559292:YKL033W
uniprot id: P36097
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tti1 family.
messages: Component of the ASTRA chromatin remodeling machinery complex composed of at least RVB1, RVB2, TRA1, TEL2, TT1 and TTI2. Component of the TTT complex composed of TEL2, TTI1 and TTI2. Interacts with TEL2 and TTI2.
messages: Component of the ASTRA complex involved in chromatin remodeling.
messages: Cytoplasm
messages: Nucleus
messages: Present with 721 molecules/cell in log phase SD medium.

559292:YOR066W
gene id: 559292:YOR066W
uniprot id: Q08471
names: Developmental Stage
names: Function
names: PTM
names: Subunit
messages: Activator of G1-specific transcription factors, MBF and SBF. Promotes both the timing of G1-specific gene transcription and cell cycle initiation. Associates with SBF- and MBF-regulated target promoters and this binding is maximal during the G1 phase, prior to maximum budding. Affects cell cycle initiation by advancing the timing of transcription of G1-specific genes. Overexpression advances the timing of SBF-dependent transcription and budding. Depletion delays both indicators of cell cycle initiation.
messages: Expressed periodically during the cell cycle with peak mRNA levels occurring at the late M/early G1 phase, prior to budding, and levels decrease rapidly as cells enter into the S phase. In early G1 peak occurs (at protein level).
messages: Interacts with transcription complexes SCB-binding factor (SBF) and MCB-binding factor (MBF) at their target promoters. Interacts with MBP1 and SWI6.
messages: Phosphorylated by CDC28.

559292:YER088C
gene id: 559292:YER088C
uniprot id: P40059
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DOT6 family.
messages: Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. DOT6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif.
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, DOT6, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, TOD6; UME1 and UME6.
messages: Nucleus
messages: Present with 2120 molecules/cell in log phase SD medium.

559292:YKL148C
gene id: 559292:YKL148C
uniprot id: Q00711
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. Interacts with EMI5/SDH5; interaction is required for FAD attachment.
messages: Mitochondrion inner membrane
messages: Present with 10400 molecules/cell in log phase SD medium.

559292:YMR089C
gene id: 559292:YMR089C
uniprot id: P40341
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides.
messages: Binds 1 zinc ion per subunit.
messages: Component of the 850 kDa m-AAA protease complex (YTA10-12) which consists of multiple copies of RCA1 and AFG3.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.
messages: Mitochondrion membrane
messages: Present with 11500 molecules/cell in log phase SD medium.

559292:YOL045W
gene id: 559292:YOL045W
uniprot id: Q08217
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Present with 2220 molecules/cell in log phase SD medium.
messages: Serine/threonine-protein kinase involved in the control of sugar metabolism and translation. Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis. This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis. Phosphorylates also the glycogen synthase GSY2 and the translation factors CAF20, TIF11 and SRO9.

559292:YHL039W
gene id: 559292:YHL039W
uniprot id: P38732
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.
messages: Cytoplasm
messages: Present with 5170 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates elongation factor 1-alpha (TEF1/TEF2) at 'Lys-30'.

559292:YBR294W
gene id: 559292:YBR294W
uniprot id: P38359
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: High affinity uptake of sulfate into the cell.
messages: Membrane

559292:YEL047C
gene id: 559292:YEL047C
uniprot id: P32614
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per monomer.
messages: Cytoplasm
messages: During anaerobic growth.
messages: Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (OSM1), essential for anaerobic growth. Involved in maintaining redox balance. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2).
messages: Present with 7620 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YLL015W
gene id: 559292:YLL015W
uniprot id: P14772
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates.
messages: Levels increase in early stationary phase.
messages: Vacuole membrane

559292:YMR026C
gene id: 559292:YMR026C
uniprot id: Q04370
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:9090384, PubMed:19687296, PubMed:22471590, PubMed:11370741, PubMed:35768507). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:35768507). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (PubMed:35768507).
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Peroxisome membrane
messages: Present with 907 molecules/cell in log phase SD medium.
messages: The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity.
messages: The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore (By similarity). The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex (By similarity).

559292:YDL003W
gene id: 559292:YDL003W
uniprot id: Q12158
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ECO1.
messages: Belongs to the rad21 family.
messages: Chromosome
messages: Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Cleaved by ESP1 at the onset of anaphase.
messages: Interacts directly with IRR1/SCC3 in cohesin complex. Cohesin complexes are composed of the SMC1 and SMC3 heterodimer attached via their hinge domain, MCD1/SCC1 which link them, and IRR1, which interacts with MCD1. The cohesin complex also interacts with SCC2, which is required for its association with chromosomes.
messages: Nucleus
messages: Phosphorylated by CDC5/Polo-like kinase at the onset of anaphase. Phosphorylation takes places at proximity to cleavage sites and is required for an efficient cleavage by ESP1.
messages: Present with 1040 molecules/cell in log phase SD medium.
messages: The C-terminal part associates with the head of SMC1, while the N-terminal part binds to the head of SMC3.
messages: centromere

559292:YNL278W
gene id: 559292:YNL278W
uniprot id: P53836
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CAF120 family.
messages: Bud neck
messages: Cytoplasm
messages: Nucleus
messages: Present with 1380 molecules/cell in log phase SD medium.
messages: Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, CAF120, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.

559292:YNL248C
gene id: 559292:YNL248C
uniprot id: Q01080
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Forms a TFIIF-like heterodimer with RPA34; the heterodimer formed by RPA34 and RPA49 can be dissociated from the Pol I core giving rise to a 12 subunit form A* of Pol I (formerly called pol A) that shows impaired transcript elongation activity and increased sensitivity to alpha-amanitin. The heterodimer formed by RPA34 and RPA49 stabilizes subunit RPA12 and stimulates RPA12-dependent RNA cleavage.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I. Subunit RPA49 can bind both single-stranded and double-stranded DNA.
messages: nucleolus

559292:YNL032W
gene id: 559292:YNL032W
uniprot id: P53965
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cytoplasm
messages: Monomer.
messages: Present with 4070 molecules/cell in log phase SD medium.
messages: Selectively cleaves the beta-phosphate at the 5-position of soluble inositol pyrophosphates. Converts 5-diphosphoinositol tetrakisphosphate (5-PP-InsP(4)) into inositol pentakisphosphate (InsP(5)), 5-diphosphoinositol pentakisphosphate (5-PP-IP(5) or 5-InsP(7)) into inositol hexakisphosphate (IP(6) or InsP(6)), and 1,5-bisdiphosphoinositol tetrakisphosphate (1,5-PP-IP(5) or InsP(8)) into 1-diphosphoinositol pentakisphosphate (1-PP-IP(5) or 1-InsP(7)) (PubMed:26828065, PubMed:29540476). Modulates inositol pyrophosphate metabolism that may have an influence in stress response (PubMed:26828065). Plays a role in actin filament organization and endocytosis (PubMed:15020461). Functions as a prion suppressing factor possibly due to its phosphatase activity against inositol pyrophosphates, which are signal transduction molecules involved in prion propagation (PubMed:28923943).

559292:YKL184W
gene id: 559292:YKL184W
uniprot id: P08432
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Cytoplasm
messages: Homodimer (PubMed:2669750). Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (By similarity).
messages: Inhibited by antizyme (AZ) OAZ1 in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.
messages: Present with 688 molecules/cell in log phase SD medium.

559292:YBR194W
gene id: 559292:YBR194W
uniprot id: P38305
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AIM4 family.
messages: Cytoplasm
messages: Increases frequency of mitochondrial genome loss and sensitivity to freeze-thaw stress and high concentrations of glucose.
messages: May interact with the nuclear pore complex.

559292:YIL038C
gene id: 559292:YIL038C
uniprot id: P06102
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Forms a NOT protein complex that comprises NOT1, NOT2, NOT3, NOT4 and NOT5. Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.
messages: Nucleus
messages: Present with 2490 molecules/cell in log phase SD medium.
messages: Was originally thought to be CDC39 (which is in fact NOT1).

559292:YGR229C
gene id: 559292:YGR229C
uniprot id: P32566
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KNR4/SMI1 family.
messages: Interacts with TYS1.
messages: Nucleus
messages: Present with 5680 molecules/cell in log phase SD medium.
messages: Protein involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of cell wall glucan and chitin synthesis.

559292:YPR124W
gene id: 559292:YPR124W
uniprot id: P49573
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: By copper deprivation, and repressed by copper sufficiency.
messages: Extensively O-glycosylated.
messages: Membrane
messages: Oligomer.
messages: Present with 1180 molecules/cell in log phase SD medium.
messages: Required for high affinity copper (probably reduced Cu I) transport into the cell.

559292:YKL062W
gene id: 559292:YKL062W
uniprot id: P33749
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes.
messages: the 9aaTAD motif (residues 237 to 245) is a transactivation domain present in a large number of yeast and animal transcription factors.

559292:YNL262W
gene id: 559292:YNL262W
uniprot id: P21951
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalytic component of the DNA polymerase epsilon complex which participates in chromosomal DNA replication (PubMed:1537345). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (PubMed:31488849). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (PubMed:12124389).
messages: DNA polymerase epsilon is a heterotetramer consisting of POL2, DPB2, DPB3 and DPB4.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus
messages: Present with 1970 molecules/cell in log phase SD medium.
messages: The CysA-type zinc finger is required for PCNA-binding.
messages: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
messages: The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C.

559292:YPR200C
gene id: 559292:YPR200C
uniprot id: Q06597
names: Function
messages: Involved in resistance to arsenic compounds.

559292:YHR028C
gene id: 559292:YHR028C
uniprot id: P18962
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family.
messages: Vacuole membrane

559292:YDR501W
gene id: 559292:YDR501W
uniprot id: Q04383
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLM2/TOS4 family.
messages: Binds to the promoters of genes with functions important for the G1/S (start) transition; primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division and transcription.
messages: Nucleus
messages: Phosphorylated by CDC28.
messages: Regulated in a cell cycle-dependent manner, peaking in G1 phase. Negatively regulated by transcription factor SBF (SWI4-SWI6 cell-cycle box binding factor).

559292:YDR440W
gene id: 559292:YDR440W
uniprot id: Q04089
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro).
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus
messages: Present with 2160 molecules/cell in log phase SD medium.
messages: Ubiquitination of histone H2B by the RAD6/UBC2-BRE1 complex to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3. Interaction with DNA is required for optimal histone methyltransferase activity.

559292:YML110C
gene id: 559292:YML110C
uniprot id: P49017
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ3.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane
messages: Present with 8100 molecules/cell in log phase SD medium.

559292:YJL159W
gene id: 559292:YJL159W
uniprot id: P32478
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIR protein family.
messages: Component of the outer cell wall layer. Required for stability of the cell wall and for optimal growth. Required for resistance against several antifungal and cell wall-perturbing agents and for tolerance to heat shock.
messages: Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from specific glutamines within the PIR1/2/3 repeats, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
messages: O-glycosylated. Extensively O-mannosylated.
messages: Positively regulated by signaling through MPK1 in response to cell wall perturbation. Induced by heat shock and nitrogen starvation. Expression is also regulated by the ACE2 and SWI5 transcription factors.
messages: Present with 14600 molecules/cell in log phase SD medium.
messages: The PIR1/2/3 repeats are required for the covalent linkage to the cell wall (By similarity). Their number varies among different strains of S.cerevisiae.
messages: The propeptide is cleaved off in the late Golgi. While both peptides are secreted, only a fraction of the mature glycoprotein is incorporated into the cell wall.
messages: cell wall

559292:YJL138C
gene id: 559292:YJL138C
uniprot id: P10081
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A (TIF1/TIF2), eIF4E (TIF45) and eIF4G (TIF4631 or TIF4632) (By similarity). Interacts with eIF4G1/TIF4631 and eIF4G2/TIF4632.
messages: Cytoplasm
messages: Present with 106000 molecules/cell in log phase SD medium.
messages: TIF1 and TIF2 code for the same protein.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

559292:YOR227W
gene id: 559292:YOR227W
uniprot id: Q12276
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GIP3/HER1 family.
messages: Cytoplasm
messages: May interact with ribosomes.
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Required for HMG2-induced endoplasmic reticulum-remodeling.

559292:YPR083W
gene id: 559292:YPR083W
uniprot id: Q06820
names: Function
names: Miscellaneous
messages: Involved in mitochondrial distribution and morphology.
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YBR168W
gene id: 559292:YBR168W
uniprot id: P38292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEX28-32 family. PEX32 subfamily.
messages: Peroxisome membrane

559292:YIL127C
gene id: 559292:YIL127C
uniprot id: P40470
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRT14 family.
messages: Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
messages: Present with 3670 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YHL034C
gene id: 559292:YHL034C
uniprot id: P10080
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with snR10 and snR11 small nuclear RNAs.
messages: Belongs to the RRM GAR family.
messages: Cytoplasm
messages: Functions in the transition of mRNAs from translation to an mRNP complex destined for decapping. High-copy-number suppressor of decapping defects. Overexpression suppresses decapping defects in both DCP1-2 and DCP2-7 mutations. Acts to promote translational repression of mRNA in conjunction with DHH1 and subsequent mRNA localization to P bodies. Promotes translational repression of mRNA during glucose deprivation.
messages: P-body
messages: Present with 12800 molecules/cell in log phase SD medium.
messages: Stress granule
messages: nucleolus

559292:YDR292C
gene id: 559292:YDR292C
uniprot id: P32916
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family.
messages: Component of the SRP (signal recognition particle) receptor (SR). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. GTP hydrolysis may enhance the fidelity of and provide unidirectionality to the targeting reaction. It is important but not essential for cell growth. May be directly involved in mitochondrial protein import.
messages: Endoplasmic reticulum membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Present with 2000 molecules/cell in log phase SD medium.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the signal recognition particle (SRP) complex subunit SRP54 (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). GTPase induced rearrangement of SR drives SRP-mediated cotranslational protein translocation into the ER (By similarity).
messages: The SRX domain is sufficient for interaction with GTP-bound SRP102/SR-beta.

559292:YOR265W
gene id: 559292:YOR265W
uniprot id: P48606
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCA family.
messages: Present with 1760 molecules/cell in log phase SD medium.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

559292:YNL288W
gene id: 559292:YNL288W
uniprot id: P53829
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
messages: Belongs to the CNOT9 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 18800 molecules/cell in log phase SD medium.
messages: Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.

559292:YEL060C
gene id: 559292:YEL060C
uniprot id: P09232
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by N- and C-terminal proteolytic cleavage. Protease B (PrB/PRB1) processing requires at least 4 cleavages. First, the signal peptide is removed from the 76 kDa preproprotease B by signal peptidase in the ER. Then, PrB removes its own Pro-region (in trans) at the N-terminus, producing a 39 kDa form before exiting the ER. In the Golgi complex, the C-terminal Post-region of the 40 kDa proprotease B undergoes protease A (PrA/PEP4)-mediated processing to a 37 kDa intermediate, which in turn is quickly processed again by PrB in trans to yield the 31 kDa mature PrB.
messages: Belongs to the peptidase S8 family.
messages: Glycosylated. Preproprotease B is a 76 kDa unglycosylated precursor that enters the endoplasmic reticulum (ER), where it receives one Asn-linked and an undetermined number of non-Asn-linked carbohydrate side chains. In the Golgi complex, the 39 kDa form becomes 40 kDa, due to elaboration of the Asn-linked side chain. The ultimate processing step removes a peptide containing the Asn-linked chain. Mature PrB has only non-Asn-linked carbohydrates.
messages: Present with 1600 molecules/cell in log phase SD medium.
messages: Repressed by glucose.
messages: Vacuolar proteinase B involved in protein degradation in the vacuole. Among other substrates, acts on carboxypeptidase Y (cpY/PRC1) to activate it by processing its Pro-peptide. Required for meiosis and spore formation, and for optimal survival in stationary phase.
messages: Vacuole
messages: [beta] is the prion form of PrB. In contrast to other prions, [beta] is not the result of a conformational change of the cellular PrB, but distinguishes itself by autoactivation in trans. Usually, PrB is already involved in its own maturatiuon, but PrA plays a critical role. PrpA mutants lack PrB. However, in growth conditions that favor PRB1 expression, PrB activity persists in PrA mutants due to autocleavage of PrB in trans. This condition is stably transmitted to daughter cells in mitosis. [beta] can be cured by growing in PRB1-repressing conditions. Once a cell has lost PrB activity, it remains stably inactive. Thus, there are 2 alternative states, that are chromosomally identical, but phenotypically distinct. Since PrA is able to activate PrB, normal cells always carry the [beta] prion. Its absence and transmission are only observable in the absence of PrA.

559292:YLR399C
gene id: 559292:YLR399C
uniprot id: P35817
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Heterochromatin spreading downstream of the silent mating-type locus HMR.
messages: Interacts with the TFIID subunit TAF7 and with acetylated histones H3 and H4.
messages: Nucleus
messages: Phosphorylated by the casein kinase CK2 complex.
messages: Present with 8100 molecules/cell in log phase SD medium.
messages: Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation.

559292:YOR201C
gene id: 559292:YOR201C
uniprot id: P25270
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Mitochondrion
messages: Present with 2760 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 2270 (Gm2270) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This modification seems to be important for the normal accumulation of the mitochondrial large ribosomal subunit.

559292:YLR023C
gene id: 559292:YLR023C
uniprot id: Q07959
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.
messages: Belongs to the ADIPOR family.
messages: Endoplasmic reticulum membrane

559292:YFR005C
gene id: 559292:YFR005C
uniprot id: P43589
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 45S U1.U2.U4/U6.U5 penta-snRNP particle, a subcomplex of the spliceosome.
messages: Nucleus
messages: Present with 167 molecules/cell in log phase SD medium.
messages: Promotes the assembly of newly synthesized U4 snRNA into the U4/U6 snRNP particle. Required for splicing of pre-mRNA.

559292:YPR040W
gene id: 559292:YPR040W
uniprot id: Q12199
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIP41 family.
messages: Cytoplasm
messages: Interacts with TAP42 and NPR1.
messages: Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Indirectly activates the PP2A phosphatase SIT4 via interaction with its suppressor TAP42. This interaction is enhanced under nitrogen limitation conditions. Also has a role in regulation of NPR1 in response to nitrogen limitation.
messages: Nucleus
messages: Phosphorylation. Dephosphorylated by SIT4.

559292:YGL146C
gene id: 559292:YGL146C
uniprot id: P53117
names: Function
names: Subcellular Location Annotation
messages: May be involved in the modulation of rDNA transcription.
messages: Membrane

559292:YDR477W
gene id: 559292:YDR477W
uniprot id: P06782
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Component of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a heterotrimeric complex composed of an alpha subunit (SNF1), a regulatory subunit beta (GAL83 and substoichiometric alternate beta subunits SIP1 and SIP2), and a regulatory subunit gamma (SNF4) (PubMed:2557546, PubMed:2481228, PubMed:7813428, PubMed:9121458, PubMed:15719021, PubMed:17851534). Interacts with the transcriptional activator SIP4 (PubMed:8628258). Interacts with SAK1 (PubMed:12748292, PubMed:16847059). Interacts with CTK1 (PubMed:16182287): Interacts with adenylate cyclase CYR1 (PubMed:26309257).
messages: Cytoplasm
messages: Expression of the SNF1 gene itself is not glucose repressible (PubMed:6366513).
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylation at Thr-210 in response to glucose limitation leads to activation of kinase activity (PubMed:11486005, PubMed:12748292). ADP, but not AMP, protects the enzyme from dephosphorylation at Thr-210 by GLC7 (PubMed:22019086).
messages: Present with 589 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase essential for release from glucose repression (PubMed:3526554, PubMed:6366512, PubMed:3049551, PubMed:1944227, PubMed:8289797, PubMed:8628258, PubMed:25869125). Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (PubMed:8289797, PubMed:26667037). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (PubMed:15719021). The complex also negatively regulates the HOG1 MAPK pathway in ER stress response including unfolded protein response (UPR) (PubMed:25730376, PubMed:26394309). Under nutrient/energy depletion, the complex phosphorylates and activates PAS kinase PSK1 which in turn activates PBS1, leading to the inhibition of the TORC1 signaling pathway (PubMed:25428989). SNF1 also interacts and phosphorylates adenylate cyclase CYR1 and negatively regulates the protein kinase A signaling pathway (PubMed:26309257). Also phosphorylates and regulates the transcriptional activator CAT8 (PubMed:15121831).
messages: Sumoylation by the SUMO (E3) ligase MMS21 leads to inhibition by interaction of SUMO attached to Lys-549 with a SUMO-interacting sequence motif located near the active site of SNF1, and by targeting SNF1 for glucose-induced destruction via the SLX5-SLX8 (SUMO-directed) ubiquitin ligase (PubMed:24108357).
messages: The kinase activity is positively regulated by SNF4 via sequestration of the SNF1 auto-inhibitory domain (AID) (PubMed:2557546, PubMed:17851534).
messages: The regulatory domain (RS) also called auto-inhibitory domain (AID) inhibits kinase activity of the protein kinase domain (KD) (PubMed:19474788, PubMed:20823513). The AID is sequestered by SNF4 within the AMP-activated protein kinase complex which might correspond to the activated SNF1 form (PubMed:17851534).
messages: The ubiquitin-associated domain (UBA) localized within the AID dampens kinase activation, probably by restraining SNF1-SNF4 associations (PubMed:25869125). Moreover, the UBA domain influences life span in a FKH1- and FKH2-dependent mechanism (PubMed:25869125).

559292:YFR027W
gene id: 559292:YFR027W
uniprot id: P43605
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylates in vitro.
messages: Belongs to the acetyltransferase family. ECO subfamily.
messages: Binds specifically to CHL12, RFC1, RFC2, RFC3, RFC4, RFC5 and RAD24 when members of an RFC complex. Interacts with CHL1 and MPS3.
messages: Nucleus
messages: Required for establishment of sister chromatid cohesion during S phase but not for its further maintenance during G2 or M phases or for loading the cohesin complex onto DNA. Interacts with the three known alternate replication factor C (RFC) complexes, suggesting that these complexes have essential but redundant activity in cohesion establishment. Acts by acetylating the cohesin complex component SMC3. In vitro, possesses acetyltransferase activity where it can acetylate itself and components of the cohesin complex (MCD1, IRR1 and PDS5), but is unable to acetylate histones.

559292:YPL144W
gene id: 559292:YPL144W
uniprot id: Q12245
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG4 family.
messages: Component of the 20S proteasome chaperone. Forms a heterodimer with IRC25 that binds to proteasome precursors. Interacts with POP2.
messages: Cytoplasm
messages: Involved in 20S proteasome assembly, facilitating the alpha-ring formation. Involved in maintenance of telomere length.
messages: Present with 2210 molecules/cell in log phase SD medium.

559292:YDR158W
gene id: 559292:YDR158W
uniprot id: P13663
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: By high concentrations of Met (general AA biosynthesis control).
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Present with 18400 molecules/cell in log phase SD medium.

559292:YMR091C
gene id: 559292:YMR091C
uniprot id: P32832
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RSC7/SWP82 family. RSC7 subfamily.
messages: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Together with HTL1, LDB7, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. Acidic protein important for nuclear protein localization.
messages: Interacts with ARP7, ARP9, RSC3, RSC8, RSC30 and STH1. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Component of a fungal-specific module (HTL1-LDB7-NPL6-RSC3-RSC30) within the RSC complex.
messages: Nucleus
messages: Present with 3510 molecules/cell in log phase SD medium.

559292:YER039C-A
gene id: 559292:YER039C-A
uniprot id: P0CD97
names: Caution
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Membrane
messages: Present with 98 molecules/cell in log phase SD medium.
messages: This is a truncated version of GDP-mannose transporter 2. Strain S288c has a stop codon in position 73, which disrupts the gene coding for this protein and produces two ORFs YER039C-A and YER039C. A contiguous sequence for GDP-mannose transporter 2 can be found in strain Lalvin EC1118 (AC C8Z742).

559292:YJR059W
gene id: 559292:YJR059W
uniprot id: P47116
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Essential determinant for high-affinity spermidine transport. Required for the activation of the plasma membrane proton pump PMA1 via phosphorylation of 'Ser-899'.
messages: Nucleus
messages: Present with 1420 molecules/cell in log phase SD medium.

559292:YGR281W
gene id: 559292:YGR281W
uniprot id: P53049
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Functions as a pleiotropic drug pump at the plasma membrane to clear toxic substances from the cytosol. Organic anion transporter involved in the detoxification of a wide range of toxic environmental organic anions that contain carboxyl groups (PubMed:8663018). Required for tolerance to reveromycin A, tautomycin and leptomycin B (PubMed:8663018). Required for oligomycin resistance (PubMed:8524254, PubMed:10082567). Required for rhodamine B resistance. Mediates the ATP-dependent efflux of rhodamine B (PubMed:9575223). Involved in cadmium detoxification. Displays an energy-dependent efflux of cadmium and glutathione, suggesting that YOR1 transports both compounds as a bis-glutathionato-cadmium Cd-(GS)(2) complex (PubMed:16814918). Confers resistance to rhodamine 6G and to doxorubicin (PubMed:17950691).
messages: Present with 3610 molecules/cell in log phase SD medium.
messages: Transcriptionally regulated by PDR8.

559292:YOR063W
gene id: 559292:YOR063W
uniprot id: P14126
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A mutant confers resistance to trichodermin, a trichotecene toxin produced by plant-pathogenic fungi.
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL3 forms together with ES39L one of the contact sites for the signal recognition particle that targets ribosomes to the endoplasmic reticulum membrane (PubMed:9559554, PubMed:24865971, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24865971, PubMed:22096102). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:22096102). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:22096102). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uL3 plays a role in coordinating processes of accommodating the aminoacyl-tRNA in the PTC (PubMed:22096102).
messages: Cytoplasm
messages: Methylation at His-243 by HPM1 is required for proper 60S subunit assembly and promotes translational elongation fidelity.
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YJL179W
gene id: 559292:YJL179W
uniprot id: P46988
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Cytoplasm
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Present with 721 molecules/cell in log phase SD medium.

559292:YOR279C
gene id: 559292:YOR279C
uniprot id: Q12192
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts directly with HST1 and SUM1. Required for the interaction between HST1 and SUM1.
messages: Nucleus
messages: Present with 861 molecules/cell in log phase SD medium.
messages: Tethering factor required for histone deacetylase HST1-mediated repression. Probably involved in targeting HST1 to a subset of SUM1-regulated genes.

559292:YGR221C
gene id: 559292:YGR221C
uniprot id: P50078
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKG6/TOS2 family.
messages: Bud membrane
messages: Cell membrane
messages: Phosphorylated by CDC28.
messages: Present with 56 molecules/cell in log phase SD medium.
messages: Seems to be involved in the anchoring of CDC24 to the membrane of polarized growth sites.

559292:YJR073C
gene id: 559292:YJR073C
uniprot id: P05375
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC). Can also catalyze the first methylation reaction of PE to PMME in the absence of PE methyltransferase CHO2.
messages: Endoplasmic reticulum membrane
messages: Expression is repressed by inositol and choline. The 5' flanking region contains two copies of the CATRTGAA motif and a 5'-AAACCCACACATG-3' GRFI site, which are involved in the regulation of expression. OPI1 and SIN3 play the role of repressors for OPI3 expression whereas UME6 is an activator of OPI3 expression.
messages: Mitochondrion membrane
messages: Present with 5890 molecules/cell in log phase SD medium.

559292:YOR183W
gene id: 559292:YOR183W
uniprot id: Q08559
names: Function
names: Subcellular Location Annotation
messages: Involved in K1 killer toxin resistance.
messages: Membrane

559292:YNL035C
gene id: 559292:YNL035C
uniprot id: P53962
names: Miscellaneous
messages: Present with 3970 molecules/cell in log phase SD medium.

559292:YJR077C
gene id: 559292:YJR077C
uniprot id: P23641
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Transport of phosphate groups from the cytosol to the mitochondrial matrix.

559292:YKR039W
gene id: 559292:YKR039W
uniprot id: P19145
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Active permease is phosphorylated (PubMed:7798155). The addition of glutamine causes rapid dephosphorylation and inactivation of the permease (PubMed:7798155).
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expression is repressed by ammonia (PubMed:2194797). Expression is induced by polyamines (PubMed:15707981). Both GLN3 and NIL1 bind the 5'-GATAAG-3' motif within the GAP1 promoter to activate transcription (PubMed:8636059).
messages: General amino-acid permease involved in the uptake of all the naturally occurring L-amino-acids, related compounds such as ornithine and citrulline, some D-amino acids, toxic amino acid analogs such as azetidine-2-carboxylate, and the polyamines putrescine and spermidine (PubMed:5474888, PubMed:10467005, PubMed:10373490, PubMed:10953083, PubMed:14968425, PubMed:15707981). Senses its transport substrates to set an appropriate level of transporter activity at the cell surface (PubMed:21471002). Required for FLO11 expression and invasive growth (PubMed:22844449).
messages: Ubiquitination by RSP5 and the RSP5-associated proteins BUL1 and BUL2, leads the addition of poly-ubiquitin chains being specifically formed by linkage through the lysine 63 residue of ubiquitin and mediates ammonium-induced endocytosis and degradation in the vacuole (PubMed:9614172, PubMed:10194416, PubMed:11500494, PubMed:11352928, PubMed:14523026, PubMed:15039776).

559292:YCR009C
gene id: 559292:YCR009C
uniprot id: P25343
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level.
messages: Mutations in this gene results in sensitivity to carbon, nitrogen and sulfur starvation.
messages: Present with 7390 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YHR064C
gene id: 559292:YHR064C
uniprot id: P38788
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. SSZ1 is required for ZUO1 to function efficiently as a J-protein for SSB1/SSB2. Also involved in pleiotropic drug resistance by post-translational activation of transcription factor PDR1.
messages: Cytoplasm
messages: Does not seem to bind unfolded protein substrates, as its C-terminal putative peptide-binding domain is not required for its function.
messages: Neither ATP binding nor ATP hydrolysis is required for SSZ1 function.
messages: Present with 73600 molecules/cell in log phase SD medium.
messages: RAC is a heterodimer of the Hsp70/DnaK-type chaperone SSZ1 and the Hsp40/DnaJ-type chaperone ZUO1. RAC associates with ribosomes via ZUO1.

559292:YGL098W
gene id: 559292:YGL098W
uniprot id: P53146
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the USE1 family.
messages: Component of a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6.
messages: Endoplasmic reticulum membrane
messages: Present with 937 molecules/cell in log phase SD medium.
messages: SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

559292:YMR127C
gene id: 559292:YMR127C
uniprot id: P40963
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation at Lys-168 is required for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Cytoplasm
messages: Heterochromatin spreading downstream of the silent mating-type locus HMR.
messages: Histone acetyltransferase (HAT) subunit of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing and G0 control.
messages: Interacts with CAC1. Component of the SAS complex, at least composed of SAS2, SAS4 and SAS5. These three proteins constitute the core of the complex and are sufficient to acetylate histones. SAS4 is essential for HAT activity of the complex, while SAS5 is required for maxiaml HAT activity.
messages: Nucleus

559292:YDL018C
gene id: 559292:YDL018C
uniprot id: Q12403
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Involved in vesicular protein trafficking.
messages: Present with 3190 molecules/cell in log phase SD medium.

559292:YBR239C
gene id: 559292:YBR239C
uniprot id: P38140
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERT1/acuK family.
messages: Cytoplasm
messages: Increases the periodicity of transcriptional and metabolic oscillation.
messages: Nucleus
messages: Present with 85 molecules/cell in log phase SD medium.
messages: Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition.

559292:YHR033W
gene id: 559292:YHR033W
uniprot id: P38690
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Cytoplasm

559292:YGR283C
gene id: 559292:YGR283C
uniprot id: P53336
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.
messages: Present with 2820 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YGR197C
gene id: 559292:YGR197C
uniprot id: P46950
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: May function as a N-methyl-N'nitro-N-nitrosoguanidine (MNNG) export permease.
messages: Membrane
messages: To yeast YJR015W.
messages: Transcriptionally regulated by PDR8.

559292:YHR126C
gene id: 559292:YHR126C
uniprot id: P38832
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Expression is regulated by AZF1.

559292:YKL129C
gene id: 559292:YKL129C
uniprot id: P36006
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Interacts (via myosin motor domain) with SHE4; this interaction is important for proper localization and may regulate the interaction of the motor domain with actin. Interacts (via SH3 domain) with VRP1; this interaction is required for localization to sites of polarized growth and may regulate the interaction of the tail domain with actin. Interacts (via SH3 domain) with PAN1; this interaction is important for late stages of endocytopsis. Interacts (via SH3 domain) with BBC1 and LAS17. Interacts (via C-terminal acidic tail) with ARC19 and ARC40; ARC19 and ARC40 are Arp2/3 complex subunits.
messages: One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.
messages: Phosphorylation of the TEDS site (Ser-357) is required for the polarization of the actin cytoskeleton and for ligand-induced, but not for constitutive internalization of STE2. Phosphorylation probably activates the myosin-I ATPase (By similarity). Ser-357 is phosphorylated by CLA4 and STE20 in vitro.
messages: Present with 155 molecules/cell in log phase SD medium.
messages: The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.
messages: The tail domain participates in molecular interactions that specify the role of the motor domain. It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).
messages: actin patch

559292:YOR014W
gene id: 559292:YOR014W
uniprot id: P38903
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Cytoplasm
messages: Multicopy suppressor of ROX3 and HSP60.
messages: Nucleus
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
messages: Present with 300 molecules/cell in log phase SD medium.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

559292:YBR162C
gene id: 559292:YBR162C
uniprot id: P38288
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA52 family.
messages: Present with 12300 molecules/cell in log phase SD medium.
messages: Secreted

559292:YDR078C
gene id: 559292:YDR078C
uniprot id: P38957
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHU2 family.
messages: Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2.
messages: Nucleus
messages: Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Required for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation.

559292:YHR214C-B
gene id: 559292:YHR214C-B
uniprot id: O13535
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YHR214C-C ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YHR216W
gene id: 559292:YHR216W
uniprot id: P38697
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. In contrast to the other IMPDH alleles IMD3 and IMD4, the enzymatic activity of IMD2 seems to be intrinsically drug resistant.
messages: Cytoplasm
messages: Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).
messages: Induced by MPA resulting in resistance to the drug. Repressed by nutrient limitation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Present with 7870 molecules/cell in log phase SD medium.

559292:YMR150C
gene id: 559292:YMR150C
uniprot id: P28627
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP1 subfamily.
messages: Catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. The two catalytic IMP subunits seem to have non-overlapping substrate specificities. IMP1 substrates include nuclear encoded CYB2, mitochondrially encoded COX2, NADH-cytochrome b5 reductase and GUT2.
messages: Component of the mitochondrial inner membrane peptidase (IMP) complex which at least consists of IMP1, IMP2 and SOM1.
messages: Mitochondrion inner membrane

559292:YNL289W
gene id: 559292:YNL289W
uniprot id: P24867
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. PCL1,2 subfamily.
messages: By transcription factor SBF (SWI4-SWI6 cell-cycle box binding factor) in a cell cycle-regulated manner. Peaks in G1 phase.
messages: Cytoplasm
messages: Forms a cyclin-CDK complex with PHO85 (PubMed:7973730, PubMed:9032248). Interacts with HMS1, NCP1 and NPA3 (PubMed:15082539, PubMed:9032248). Interacts with DMA1 (PubMed:23264631).
messages: G1/S-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 phosphorylates LCB4, which is required for its ubiquitination and degradation. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit.
messages: Nucleus
messages: Phosphorylated by PHO85; necessary for interaction with DMA1 and subsequent degradation.
messages: Present with 606 molecules/cell in log phase SD medium.
messages: Ubiquitinated by E3 ubiquitin ligase DMA1 in response to nutrient condition; this targets PCL1 for destruction.

559292:YJL143W
gene id: 559292:YJL143W
uniprot id: P39515
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21 (PubMed:15797382, PubMed:27265872). The complex interacts with the TIM44 component of the PAM complex (PubMed:15797382).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane
messages: Present with 1210 molecules/cell in log phase SD medium.
messages: The disulfide bond is required for stabilization of the TIM23 complex.

559292:YNL328C
gene id: 559292:YNL328C
uniprot id: P42834
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PAM16/TIM16 and is recruited by the PAM complex.
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial biogenesis and protein folding. Participates in the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner, probably by stimulating activity of mtHSP70 (SSC1).
messages: Present with 573 molecules/cell in log phase SD medium.

559292:YGL082W
gene id: 559292:YGL082W
uniprot id: P53155
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 7620 molecules/cell in log phase SD medium.

559292:YKL146W
gene id: 559292:YKL146W
uniprot id: P36062
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
messages: Vacuole membrane

559292:YDR005C
gene id: 559292:YDR005C
uniprot id: P41910
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Cytoplasm
messages: Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus
messages: Phosphorylated by PKA in a TORC1-dependent manner. Phosphorylation at PKA consensus sites RRxS/T decreases upon rapamycin treatment.
messages: Present with 1720 molecules/cell in log phase SD medium.

559292:YDR542W
gene id: 559292:YDR542W
uniprot id: Q03050
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YHR143W-A
gene id: 559292:YHR143W-A
uniprot id: P40422
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts, via its C-terminus, with TFIIIC subunit TFC4.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center.
messages: Present with 907 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.
messages: nucleolus

559292:YBR141C
gene id: 559292:YBR141C
uniprot id: P38278
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT2 family.
messages: Loss of N(1)-methyladenine(2142) in 25S rRNA. Confers anisomycin and peroxide sensitivity to the cells as well as slight defects in ribosome subunit joining.
messages: Present with 623 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit.
messages: nucleolus

559292:YBR160W
gene id: 559292:YBR160W
uniprot id: P00546
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles (By similarity). Required to drive the G1-S transition (PubMed:2664468). More than 200 substrates have been identified (PubMed:14574415). Substrate specificity is in part regulated by the bound cyclin protein (By similarity). Phosphorylates YTA7 during S-phase to promote transcription of histones (PubMed:22156209).
messages: Forms a stable but non-covalent complex with the CKS1 protein and with a cyclin.
messages: Phosphorylation at Thr-18 or Tyr-19 inactivates the enzyme, while phosphorylation at Thr-169 activates it.
messages: Present with 6670 molecules/cell in log phase SD medium.

559292:YDR054C
gene id: 559292:YDR054C
uniprot id: P14682
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Capable, in vitro, to ubiquitinate histone H2A.
messages: Cytoplasm
messages: Interacts with CDC53. Component of the E3 ubiquitin ligase complexes SCF with CDC53, SKP1/CBF3D, HRT1 and some F-box proteins like MET30 and CDC4.
messages: Mediates the initiation of DNA replication (transition of G1 to S phase in cell cycle). Essential component of the E3 ubiquitin ligase complex SCF (SKP1-CUL1-F-box protein), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the regulation of methionine biosynthesis genes and in the degradation of CDC6 together with CDC4 and CDC53.
messages: Nucleus
messages: Present with 8170 molecules/cell in log phase SD medium.
messages: The acidic C-terminal extension is essential for the cell cycle function.

559292:YJL189W
gene id: 559292:YJL189W
uniprot id: P04650
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL39 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). eL39 interacts with YIH1 (PubMed:22404850).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

559292:YDR448W
gene id: 559292:YDR448W
uniprot id: Q02336
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9. Component of the ADA/GCN5 complex that consists of HFI1/ADA1, ADA2, ADA3, SPT20/ADA5 and GCN5 and is probably a subcomplex of SAGA. Component of the 0.8 MDa ADA complex, which at least consists of ADA2, ADA3, AHC1 and GCN5. ADA2 interacts with GCN5.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B.
messages: Nucleus
messages: Present with 1720 molecules/cell in log phase SD medium.

559292:YGR280C
gene id: 559292:YGR280C
uniprot id: P53335
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PINX1 family.
messages: Interacts with EST2.
messages: Involved in rRNA-processing at A0, A1 and A2 sites through its action in U18 and U24 snoRNA 3'-end final trimming. Negative regulator of telomerase through competition for binding to EST2 with TLC1.
messages: Present with 3850 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YGL126W
gene id: 559292:YGL126W
uniprot id: P53012
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (PubMed:26504167, PubMed:29526591, PubMed:32915949) (By similarity). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (PubMed:29526591) (By similarity). May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Involved in phospholipid biosynthesis (PubMed:7706223, PubMed:29417057, PubMed:32915949) (By similarity).
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YMR315W
gene id: 559292:YMR315W
uniprot id: Q04869
names: Miscellaneous
messages: Present with 9600 molecules/cell in log phase SD medium.

559292:YLR035C-A
gene id: 559292:YLR035C-A
uniprot id: Q12088
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YLR035C-B ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YER139C
gene id: 559292:YER139C
uniprot id: P40084
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RPAP2 family.
messages: Cytoplasm
messages: Interacts with RPO21.
messages: Nucleus
messages: Present with 5480 molecules/cell in log phase SD medium.
messages: RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that dephosphorylates 'Ser-5' of the CTD and regulates RNA polymerase II during the transition from 'Ser-5' to 'Ser-2' phosphorylation.

559292:YBL030C
gene id: 559292:YBL030C
uniprot id: P18239
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:24474793). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Monomer.
messages: The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA) (PubMed:24474793). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (PubMed:24474793).
messages: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

559292:YJR054W
gene id: 559292:YJR054W
uniprot id: P47114
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KCH1 low affinity K(+) transporter family.
messages: Cell membrane
messages: Expression is strongly induced during the response to alpha-factor.
messages: Leads to high-affinity Ca(2+) influx system (HACS) deficiency (PubMed:21252230, PubMed:23204190). Causes a large increase of cell death in response to mating pheromone, when PRM6/KCH2 is also deleted (PubMed:23204190).
messages: Low affinity potassium transporter that, with PRM6/KCH2, participates in high-affinity Ca(2+) influx system (HACS) activation during the response to mating pheromone (PubMed:21252230, PubMed:23204190). Directly promotes K(+) influx and HACS may electrochemically respond to this K(+) influx (PubMed:23204190). KCH1 and KCH2 act at the apex of the calcium signaling pathway that is used for survival during prolonged exposures to mating pheromones (PubMed:23204190).
messages: Present with 538 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YPL074W
gene id: 559292:YPL074W
uniprot id: P40328
names: Miscellaneous
names: Sequence Caution
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: Present with 259 molecules/cell in log phase SD medium.
messages: Rearrangements.

559292:YOL165C
gene id: 559292:YOL165C
uniprot id: Q08361
names: Caution
names: Function
names: Similarity
messages: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
messages: In contrast to other aldo/keto reductase 2 proteins, it lacks the N-terminal half which contains the active site. It is therefore unlikely that it acts as a functional oxydoreductase.
messages: Putative aryl-alcohol dehydrogenase.

559292:YPL052W
gene id: 559292:YPL052W
uniprot id: Q02803
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ODC antizyme family.
messages: Interacts with ODC/SPE1 and thereby sterically blocks ODC homodimerization.
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels (PubMed:15538383). Binds to ODC/SPE1 monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:18089576).

559292:YGR088W
gene id: 559292:YGR088W
uniprot id: P06115
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Present with 319 molecules/cell in log phase SD medium.
messages: This is one of two catalases in S.cerevisiae; the other is catalase A, which is the peroxisomal form.

559292:YDL153C
gene id: 559292:YDL153C
uniprot id: Q12136
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAS10 family.
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Primarily required at the G2/M phase. Essential for viability: involved in nucleolar processing of pre-18S ribosomal RNA as part of the ribosomal small subunit (SSU) processome.
messages: When overexpressed, has a role in the structure of silenced chromatin. Overproduction causes derepression of gene expression at both HML and HMR, as well as at the rDNA locus and at telomeres.
messages: nucleolus

559292:YOR363C
gene id: 559292:YOR363C
uniprot id: P52960
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Autoregulated. Induced upon growth on fatty acids.
messages: Heterodimer of PIP2 and OAF1.
messages: Nucleus
messages: The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. Activity is inhibited by OAF1 under non-inducing conditions. Activity is repressed by glucose.
messages: the 9aaTAD motif (residues 985 to 993) is a transactivation domain present in a large number of yeast and animal transcription factors.

559292:YNL111C
gene id: 559292:YNL111C
uniprot id: P40312
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Endoplasmic reticulum membrane
messages: Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. It plays a role in fatty-acid desaturation and is also involved in several steps of the sterol biosynthesis pathway, particularly in the 4-demethylation of the 4,4'-dimethyl zymosterol.
messages: Microsome membrane
messages: Present with 5390 molecules/cell in log phase SD medium.

559292:YNL254C
gene id: 559292:YNL254C
uniprot id: P53850
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC4 family.
messages: Cytoplasm
messages: May be involved in a process influencing telomere capping.
messages: Nucleus
messages: Present with 799 molecules/cell in log phase SD medium.

559292:YIL150C
gene id: 559292:YIL150C
uniprot id: P32354
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MCM10 family.
messages: Diubiquitinated in a cell cycle-regulated manner. Ubiquitination first appears in late G(1) and persists throughout S phase.
messages: Nucleus
messages: Present with 1860 molecules/cell in log phase SD medium.
messages: Required for DNA synthesis. Required for entry into or completion of S phase. Involved in DNA replication and seems to participate in the activation of the pre-replication complex (pre-RC) and in transcription elongation. May play a role as a key coordinator in assembling the replication fork. Proposed to function at replication origins following the binding of the MCM2-7 complex prior to the recruitment of CDC45. Probably is required to stimulate phosphorylation of the MCM2-7 complex by the CDC7-DBF4 kinase complex. May recruit the DNA polymerase alpha:primase complex to replication origins and is required to maintain it on chromatin independently of CDC45. May also play a role in transcriptional silencing.
messages: Self-associates; assembles into large homomultimeric complexes of approximately 800 kDa. Associates with the MCM2-7 complex and the DNA polymerase alpha:primase complex. Interacts with ORC1, ORC2, MCM2, MCM3, CDC54/MCM4, MCM6, CDC47/MCM7, RFA2, CDC45, POL1, PRI2, POL12, SIR2 and SIR3. The diubiquitinated form interacts with POL30/PCNA C-terminus.
messages: The zinc finger-like domain binds a zinc ion and is involved in self-association.

559292:YGL204C
gene id: 559292:YGL204C
uniprot id: P53089
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Membrane

559292:YLR207W
gene id: 559292:YLR207W
uniprot id: Q05787
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sel-1 family.
messages: Component of the HRD1 ubiquitin ligase complex which contains the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873065, PubMed:16873066, PubMed:16845381). Within the complex, interacts directly with HRD1 and YOS9 (via N-terminus) (PubMed:11018054, PubMed:22262864, PubMed:28682307). In ERAD-L, HRD3 and YOS9 jointly bind misfolded glycoproteins in the endoplasmic reticulum (ER) lumen (PubMed:32327568). Movement of ERAD-L substrates through the ER membrane is facilitated by HRD1 and DER1 which have lateral gates facing each other and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568). The HRD1 complex interacts with the heterotrimeric CDC48-NPL4-UFD1 ATPase complex which is recruited by UBX2 via its interaction with CDC48 and which moves ubiquitinated substrates to the cytosol for targeting to the proteasome (PubMed:16873066, PubMed:16619026). The HRD1 complex interacts with the ERAD substrates HMG1 and HMG2 (PubMed:11390656). Interacts with KAR2 (PubMed:16873065).
messages: Component of the endoplasmic reticulum quality control (ERQC) system involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M. Stabilizes the HRD1 ubiquitin-protein ligase. Also functions in recruiting misfolded protein substrates in conjunction with YOS9.
messages: Endoplasmic reticulum membrane

559292:YGR060W
gene id: 559292:YGR060W
uniprot id: P53045
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects mitochondrial activities and leads to an increase in intermediate sterols and a corresponding decrease in zymosterol and ergosterol production.
messages: Belongs to the sterol desaturase family.
messages: C-4 methylsterol oxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:8552601, PubMed:12880870, PubMed:29773647). ERG25 is a catalytic component of the C-4 demethylation complex that catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols (PubMed:8552601, PubMed:12880870). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reducti…
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG27 and ERG28.
messages: Present with 77100 molecules/cell in log phase SD medium.
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

559292:YIL065C
gene id: 559292:YIL065C
uniprot id: P40515
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIS1 family.
messages: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation. Required for targeting MDV1 to the mitochondria. Regulates the assembly of DNM1 into punctate structures, in the mitochondrial tubules, promoting mitochondrial membrane constriction and/or division.
messages: Interacts with DNM1 and MDV1.
messages: Mitochondrion outer membrane
messages: Present with 2410 molecules/cell in log phase SD medium.
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

559292:YJR125C
gene id: 559292:YJR125C
uniprot id: P47160
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the clathrin adapter GGA2, and VPS27.
messages: Involved in the recruitment of clathrin to the Golgi network and endosomes to form clathrin coated vesicles. Plays a role in the trafficking of clathrin between the Golgi network and endosomes. Binds to membranes enriched in phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) and, in association with VPS27, is involved in protein sorting at the multivesicular body (MVB).
messages: clathrin-coated vesicle membrane
messages: trans-Golgi network membrane

559292:YJL116C
gene id: 559292:YJL116C
uniprot id: P46955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUN family.
messages: Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase.
messages: Mitochondrion

559292:YML035C
gene id: 559292:YML035C
uniprot id: P15274
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: AMP deaminase plays a critical role in energy metabolism.
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Present with 3910 molecules/cell in log phase SD medium.

559292:YLR177W
gene id: 559292:YLR177W
uniprot id: Q06251
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSP1 family.
messages: Cytoplasm
messages: Present with 1550 molecules/cell in log phase SD medium.

559292:YCR030C
gene id: 559292:YCR030C
uniprot id: P25623
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYP1 family.
messages: Bud neck
messages: Interacts with CDC3, CDC10, CDC11, CDC12, EDE1 and EPS15.
messages: Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during budding and/or cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Also plays a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages. May act through the RHO2 signaling pathway to repolarize cortical actin patches in profilin-deficient cells.
messages: Present with 4280 molecules/cell in log phase SD medium.

559292:YKL195W
gene id: 559292:YKL195W
uniprot id: P36046
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cu(2+) or Zn(2+).
messages: Mitochondrion inner membrane
messages: Monomer. Interacts with the FAD-linked sulfhydryl oxidase ERV1 and with the substrate proteins COX17, TIM9, and TIM13, forming transient intermolecular disulfide bridges. Interacts with FCJ1.
messages: Present with 5040 molecules/cell in log phase SD medium.
messages: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced MIA40 is reoxidized by FAD-linked sulfhydryl oxidase ERV1.
messages: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.

559292:YCR035C
gene id: 559292:YCR035C
uniprot id: P25359
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:17173052 and PubMed:17174896, only DIS3/RRP44 subunit of the exosome core has exonuclease activity.
messages: Belongs to the RNase PH family.
messages: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure. Interacts with NIP7 and NOP8. Interacts strongly with RRP46.
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP43 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.
messages: Present with 3180 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YGR014W
gene id: 559292:YGR014W
uniprot id: P32334
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HKR1/MSB2 family.
messages: Cell membrane
messages: Interacts with CDC42 and SHO1.
messages: O-glycosylated in the Ser/Thr-rich regions.
messages: Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. Partially redundant with the SHO1 osmosensing branch for the activation of STE11.
messages: Present with 1320 molecules/cell in log phase SD medium.

559292:YOL105C
gene id: 559292:YOL105C
uniprot id: Q12215
names: Subcellular Location Annotation
messages: Membrane

559292:YOL116W
gene id: 559292:YOL116W
uniprot id: P22148
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: May function as a transcriptional activator. Increased dosage of MSN1 restores invertase expression in yeast mutants defective in the SNF1 protein kinase, and msn1 disruption reduced derepression of invertase in the wild-type. May affect SUC2 expression. Expression of MSN1 enhances growth in iron-limiting conditions.
messages: Nucleus
messages: Present with 491 molecules/cell in log phase SD medium.

559292:YPL100W
gene id: 559292:YPL100W
uniprot id: Q02887
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Contains a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Cytoplasm
messages: Present with 6020 molecules/cell in log phase SD medium.
messages: Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage. Essential for maturation of proaminopeptidase I.
messages: The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway and for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium and in both its recruitment to and dissociation from the PAS under starvation conditions.
messages: Vacuole

559292:YBL091C
gene id: 559292:YBL091C
uniprot id: P38174
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site. Also zinc has been proposed to be the physiological cofactor for yeast.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays only a minor role in N-terminal methionine removal. Less efficient when the second residue is Val, Gly, Cys or Thr.
messages: Cytoplasm
messages: Irreversibly inhibited by the fungal metabolite fumagillin, an antiangiogenic drug. Subject to product inhibition by cytosolic methionine.
messages: Present with 1080 molecules/cell in log phase SD medium.

559292:YHR037W
gene id: 559292:YHR037W
uniprot id: P07275
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: By proline and is regulated by a common control element encoded by the PUT3 gene.
messages: Mitochondrion inner membrane
messages: Present with 17200 molecules/cell in log phase SD medium.

559292:YGL144C
gene id: 559292:YGL144C
uniprot id: P53118
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

559292:YNL030W
gene id: 559292:YNL030W
uniprot id: P02309
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Nucleus
messages: Present with 524000 molecules/cell in log phase SD medium.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Histone H4 is a component of the UAF (upstream activation factor) complex which consists of UAF30, RRN5, RRN9, RRN10, and histones H3 and H4.

559292:YMR083W
gene id: 559292:YMR083W
uniprot id: P07246
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Present with 11600 molecules/cell in log phase SD medium.

559292:YPR144C
gene id: 559292:YPR144C
uniprot id: Q06512
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CBF/MAK21 family.
messages: Interacts with NOP14 and MPP10. Interacts with snoRNA U3. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein.
messages: Present with 1630 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YNL085W
gene id: 559292:YNL085W
uniprot id: P40850
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the XPG/RAD2 endonuclease family, only two of the seven Asp residues involved in Mg(2+) binding are conserved suggesting that it has no nuclease activity.
messages: Belongs to the XPG/RAD2 endonuclease family.
messages: Interacts (via C-terminus) with PBP1 (via C-terminus).
messages: Involved in 3'-UTR mediated RNA regulation (PubMed:15082763). Binds to RNA-binding and RNA regulatory proteins (PubMed:15082763). Complexes with PAB1-binding protein to promote mRNA interactions with poly(A)-binding protein (PubMed:15082763). Promotes mating-type switching in mother cells by positively regulating HO expression (PubMed:15082763).
messages: Normal vegetative cell population growth rate and morphology (PubMed:15082763). Decreases expression from the HO locus (PubMed:15082763).
messages: Present with 3430 molecules/cell in log phase SD medium.
messages: cytosol

559292:YJL104W
gene id: 559292:YJL104W
uniprot id: P42949
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.
messages: Homodimer and heterodimer with PAM18. Homodimerization may not be relevant in vivo, while heterodimerization is essential for activity regulation of mtHSP70. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18. Interacts with MDJ2.
messages: Mitochondrion inner membrane
messages: Present with 3180 molecules/cell in log phase SD medium.
messages: The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function.

559292:YFR043C
gene id: 559292:YFR043C
uniprot id: P43615
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the IRC6 family.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.
messages: Involved in gross chromosomal rearrangements (GCRs) and telomere healing.

559292:YDR391C
gene id: 559292:YDR391C
uniprot id: Q04170
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 6020 molecules/cell in log phase SD medium.

559292:YBR132C
gene id: 559292:YBR132C
uniprot id: P38090
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: General amino acid permease with broad substrate specificity. Can also transport carnitine.
messages: Membrane

559292:YNR063W
gene id: 559292:YNR063W
uniprot id: P53749
names: Subcellular Location Annotation
messages: Nucleus

559292:YBL042C
gene id: 559292:YBL042C
uniprot id: P38196
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: High-affinity transport of uridine.
messages: Membrane

559292:YJL205C
gene id: 559292:YJL205C
uniprot id: Q02820
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCE101 family.
messages: Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. May be part of the export machinery or may also be a substrate for non-classical export.
messages: Membrane

559292:YPL098C
gene id: 559292:YPL098C
uniprot id: Q02889
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Membrane
messages: Required for cell viability in cells lacking mitochondrial DNA.

559292:YKL046C
gene id: 559292:YKL046C
uniprot id: P36091
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 76 family.
messages: Cell membrane
messages: Present with 2580 molecules/cell in log phase SD medium.
messages: Required for normal synthesis of the cell wall.

559292:YBR267W
gene id: 559292:YBR267W
uniprot id: P38344
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with nascent pre-60S particles that have not yet entered the translating pool, and is released from mature 60S subunits. Interacts with pre-60S factors ARX1 and RPL24. Interacts with JJJ1.
messages: Belongs to the REI1 family.
messages: Cytoplasm
messages: Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors like ARX1, TIF6 and ALB1 before newly synthesized large ribosomal subunits enter translation. Cooperates with the co-chaperone JJJ1 in the release of the nuclear-export factor ARX1. May act redundantly with REH1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on ARX1 recycling.
messages: Present with 830 molecules/cell in log phase SD medium.

559292:YAL061W
gene id: 559292:YAL061W
uniprot id: P39713
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH.
messages: Cytoplasm
messages: Expression is controlled by the PDR1 transcription factor and the glucose-responsive transcription factor RGT1.
messages: Nucleus
messages: Present with 3090 molecules/cell in log phase SD medium.

559292:YLR157C-A
gene id: 559292:YLR157C-A
uniprot id: P0CX70
uniprot id: P0CX71
uniprot id: P0CX72
uniprot id: P0CX73
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR6 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ER1 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-PL is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YBL028C
gene id: 559292:YBL028C
uniprot id: P38202
names: Miscellaneous
names: Similarity
messages: Belongs to the UPF0642 family.
messages: Present with 6210 molecules/cell in log phase SD medium.

559292:YGR185C
gene id: 559292:YGR185C
uniprot id: P36421
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction: L-tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (PubMed:8509419, PubMed:3535890, PubMed:10588711, PubMed:10677221, PubMed:10766779). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36 (PubMed:10677221). Also involved in nuclear tRNA export (PubMed:10588711). Also attaches D-Tyr to tRNA(Tyr), this reaction is about 150-fold less efficient than attachment of L-Tyr (PubMed:10766779).
messages: Cytoplasm
messages: Homodimer. Interacts with KNR4/SMI1.
messages: Inhibited by N-ethylmaleimide and p-chloromercuribenzoate.
messages: Nucleus
messages: Present with 2710 molecules/cell in log phase SD medium.

559292:YBL059W
gene id: 559292:YBL059W
uniprot id: P34224
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion membrane
messages: Present with 623 molecules/cell in log phase SD medium.

559292:YPR002W
gene id: 559292:YPR002W
uniprot id: Q12428
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PrpD family.
messages: Catalyzes the stereospecific dehydration of (2S,3S)-2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate.
messages: Present with 2730 molecules/cell in log phase SD medium.

559292:YER154W
gene id: 559292:YER154W
uniprot id: P39952
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Interacts with the large ribosome subunit of mitochondrial ribosome (PubMed:14657017, PubMed:22904327). Interacts directly with MRP20 (PubMed:14657017). Interacts with OXA1 (PubMed:25609543).
messages: Leads to reduced steady-state levels and activities of the mitochondrial ATP/ADP carrier protein AAC2.
messages: Mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane. Links mitoribosomes with the inner membrane (PubMed:22904327). Forms pores capable of accommodating translocating protein segments (PubMed:22829595). Essential for the activity and assembly of cytochrome c oxidase (PubMed:22904327). Plays a central role in the translocation and export of the N-terminal part of the COX2 protein into the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: Present with 6550 molecules/cell in log phase SD medium.

559292:YJL133W
gene id: 559292:YJL133W
uniprot id: P10566
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations).
messages: Mitochondrion inner membrane
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YPR138C
gene id: 559292:YPR138C
uniprot id: P53390
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane
messages: Present with 3820 molecules/cell in log phase SD medium.
messages: Transporter for ammonium (both charged and uncharged NH3 and NH4) to use as a nitrogen source. The affinity of MEP2 is about twenty times higher than that of MEP1. MEP3 has the lowest affinity.

559292:YPL169C
gene id: 559292:YPL169C
uniprot id: Q99257
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: Interacts with nucleoporin complex NUP84 and MTR2. Interacts with MIP6.
messages: Involved in the export of mRNA from the nucleus to the cytoplasm.
messages: Nucleus
messages: Present with 2830 molecules/cell in log phase SD medium.
messages: The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats.
messages: The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.
messages: The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.

559292:YCL002C
gene id: 559292:YCL002C
uniprot id: P25565
names: Subcellular Location Annotation
messages: Membrane

559292:YDR092W
gene id: 559292:YDR092W
uniprot id: P52490
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has a role in the DNA error-free postreplication repair (PRR) pathway. The UBC13/MMS2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.
messages: Heterodimer with MMS2.
messages: Present with 8970 molecules/cell in log phase SD medium.

559292:YCR020C
gene id: 559292:YCR020C
uniprot id: P25362
names: Miscellaneous
names: Similarity
messages: Belongs to the thiaminase-2 family.
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YGL162W
gene id: 559292:YGL162W
uniprot id: P53032
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SUT1 family.
messages: Cytoplasm
messages: Interacts with SSN6/CYC8.
messages: Nucleus
messages: Present with 1100 molecules/cell in log phase SD medium.
messages: Transcription factor involved in the induction of hypoxic gene transcription when the cells are shifted from aerobiosis to anaerobiosis. Involved in sterol uptake.

559292:YPL257W-B
gene id: 559292:YPL257W-B
uniprot id: Q12414
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YPL257W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YLR250W
gene id: 559292:YLR250W
uniprot id: P39931
names: Miscellaneous
messages: Present with 6900 molecules/cell in log phase SD medium.

559292:YDR459C
gene id: 559292:YDR459C
uniprot id: Q03289
names: Domain
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

559292:YDR189W
gene id: 559292:YDR189W
uniprot id: P22213
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Able to suppress the functional loss of YPT1. SLY1 is essential for cell viability. May interact indirectly, or directly with YPT1.
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Cytoplasm
messages: Interacts with SED5.
messages: Membrane
messages: Present with 5780 molecules/cell in log phase SD medium.

559292:YAR007C
gene id: 559292:YAR007C
uniprot id: P22336
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. Binds to single-stranded sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation (CAR1). Stimulates the activity of a cognate strand exchange protein (SEP1). It cooperates with T-AG and DNA topoisomerase I to unwind template DNA containing the simian virus 40 origin of DNA replication.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA). Interacts with POB3.
messages: Nucleus
messages: Present with 4100 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YHL029C
gene id: 559292:YHL029C
uniprot id: P38738
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm
messages: Present with 12500 molecules/cell in log phase SD medium.
messages: Required for replication of brome mosaic virus (BMV), a positive-strand RNA virus.

559292:YGL115W
gene id: 559292:YGL115W
uniprot id: P12904
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (SNF1), a beta (SIP1, SIP2 or GAL83) and a gamma non-catalytic subunits (SNF4). Note=Interaction between SNF1 and SNF4 is inhibited by high levels of glucose.
messages: Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (SNF1) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
messages: Cytoplasm
messages: Leads to a decrease in the length of G1 with respect to the wild-type strain along with a smaller difference in the cell cycle length of parent and daughter cells.
messages: Nucleus
messages: Present with 11700 molecules/cell in log phase SD medium.
messages: The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 2 are occupied, designated as sites 2 and 3 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Site 3 can bind either AMP, ADP or ATP (AMP, ADP or ATP 2). Site 2 binds specifically ADP (ADP 1) and is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of ADP (PubMed:22019086).

559292:YJL197W
gene id: 559292:YJL197W
uniprot id: P39538
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Interacts with FZO1.
messages: Present with 7110 molecules/cell in log phase SD medium.
messages: Ubiquitin carboxyl-terminal hydrolase that recognizes ubiquitin chains that stabilize FZO1 and promote mitochondrial fusion. UBP12 deubiquitylates FZO1 only after oligomerization.

559292:YGL092W
gene id: 559292:YGL092W
uniprot id: P49687
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin GLFG family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP145C is part of the heptameric 0.5 MDa autoassembling NUP84 NPC subcomplex (NUP84, NUP85, NUP120, NUP133, NUP145C, SEC13 and SEH1). NUP145N may bind homomeric RNA and interacts through its FG repeats with karyopherins. Interacts with MLP1 and MLP2.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP145 is autocatalytically cleaved in vivo in 2 polypeptides which assume different functions in the NPC. NUP145N as one of the FG repeat nucleoporins participates in karyopherin interactions and contains part of the autocatalytic cleavage activity. NUP145C as part of the NUP84 complex is involved in nuclear poly(A)+ RNA and tRNA export. It is also required for normal NPC distribution (probably through interactions with MLP1 and MLP2) and NPC assembly, as well as for normal nuclear envelope organization.
messages: NUP145 is autocatalytically cleaved in NUP145N and NUP145C.
messages: Nucleus membrane
messages: Present with 4630 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YEL039C
gene id: 559292:YEL039C
uniprot id: P00045
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: By low oxygen levels (hypoxia) at the level of transcription. Not expressed until the oxygen concentration is below 0.5 uM O(2).
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of ubiquinol-cytochrome c oxidoreductase. Cytochrome c then transfers this electron to the dinuclear copper A center (CU(A)) of the COX2 subunit of cytochrome oxidase, the final protein carrier in the mitochondrial electron-transport chain. Isoform 2 (CYC7) is the predominant cytochrome c under anaerobic/hypoxic conditions.
messages: Mitochondrion intermembrane space
messages: Present with 1310 molecules/cell in log phase SD medium.

559292:YHL003C
gene id: 559292:YHL003C
uniprot id: P38703
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Component of the ceramide synthase complex that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward hexacosanoyl-CoA (C26:0-CoA) (PubMed:12869556, PubMed:11694577). N-acylates sphinganine and phytosphingosine bases to form dihydroceramides and phytoceramides, respectively (PubMed:12869556). Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span.
messages: Endoplasmic reticulum membrane
messages: Expression is controlled by CBF1.

559292:YDR227W
gene id: 559292:YDR227W
uniprot id: P11978
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (PubMed:12791253). Interacts with MPS3 (PubMed:18039933). Interacts with RIS1 (PubMed:9271422). Interacts with SIR1, SIR2 and SIR3 (PubMed:11722841). Interacts with YKU80 (PubMed:14551211). Interacts with UBP10 (PubMed:10490600, PubMed:26149687).
messages: Nucleus
messages: The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR (PubMed:18039933). The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure (PubMed:18039933). Involves the compaction of chromatin fiber into a more condensed form (PubMed:18039933).

559292:YBR131W
gene id: 559292:YBR131W
uniprot id: P38273
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCZ1 family.
messages: Forms a complex with MON1. Interacts with YPT7.
messages: In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking (PubMed:10407278, PubMed:11069774, PubMed:11590240, PubMed:12208507, PubMed:12364329, PubMed:14662743, PubMed:15184059, PubMed:15721293). The CCZ1-MON1 complex acts as a guanine nucleotide-exchange factor (GEF) for Rab-type GTPase YPT7, promoting nucleotide exchange on YPT7 and triggering endosomal maturation by activating YPT7 on late endosomes (PubMed:20797862).
messages: Present with 2870 molecules/cell in log phase SD medium.
messages: Prevacuolar compartment membrane
messages: Vacuole membrane
messages: multivesicular body membrane

559292:YOR085W
gene id: 559292:YOR085W
uniprot id: P48439
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST3/OST6 family.
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:10677492, PubMed:16297388, PubMed:16096345, PubMed:15886282, PubMed:9405463, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962).
messages: Endoplasmic reticulum membrane
messages: Present with 4030 molecules/cell in log phase SD medium.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

559292:YLR295C
gene id: 559292:YLR295C
uniprot id: Q12349
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase h subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 6140 molecules/cell in log phase SD medium.

559292:YDR145W
gene id: 559292:YDR145W
uniprot id: Q03761
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF12 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
messages: In TFIID, TAF12 heterodimerizes with TAF4, forming ultimately an octamer consisting of a TAF6/TAF9 heterotetramer core flanked by TAF4/TAF12 dimers on either side, similar to the histone H2A/H2B/H3/H4 octamer. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. Component of the 1.8 MDa SAGA complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9.
messages: Nucleus
messages: Present with 930 (+/-45) molecules/cell in log phase SD medium.

559292:YJL198W
gene id: 559292:YJL198W
uniprot id: P39535
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Expression is constitutive and independent of inorganic phosphate concentration and PHO4 activity.
messages: Low-affinity phosphate transporter involved in the control of cellular phosphate levels.
messages: Membrane
messages: Present with 3430 molecules/cell in log phase SD medium.

559292:YKL222C
gene id: 559292:YKL222C
uniprot id: P35995
names: Subcellular Location Annotation
messages: Nucleus

559292:YDR222W
gene id: 559292:YDR222W
uniprot id: Q04925
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Cytoplasm
messages: Present with 1010 molecules/cell in log phase SD medium.

559292:YOR313C
gene id: 559292:YOR313C
uniprot id: P09937
names: Developmental Stage
names: Function
messages: Expressed at 6 of 8 hours of sporulation with maximal transcript accumulation occurring at 8 to 12 hours, a time at which the meiotic events if sporulation have been completed and the deposition of spore wall components is beginning.
messages: Not essential for sporulation. Might be a component of the cell wall.

559292:YLR106C
gene id: 559292:YLR106C
uniprot id: Q12019
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with pre-60S ribosomes in the nucleoplasm (PubMed:11583615, PubMed:12374754, PubMed:15260980, PubMed:19737519). Interacts (via its hexameric AAA ATPase ring) with the RIX1 complex (via RIX1); this interaction is crucial for recruitment of MDN1 to the pre-ribosomal particle (PubMed:15260980, PubMed:26619264). Interacts (via VWFA/MIDAS domain) with YTM1 (via UBL domain) (PubMed:20542003). Interacts (via VWFA/MIDAS domain) with RSA4 (via UBL domain) (PubMed:19737519, PubMed:20542003).
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (PubMed:15260980, PubMed:15528184, PubMed:19737519, PubMed:20542003). At an early stage in 60S maturation, mediates the dissociation of the NOP7 complex (YTM1-ERB1-NOP7) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (PubMed:20542003). Subsequently recruited to the nucleoplasmic particles through interaction with the RIX1 complex. This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (PubMed:26619264). After remodeling, removes the ribosome biogenesis factor RSA4 in an ATP hydrolysis-driven step from pre-60S ribosomal subunits, rendering them competent for export from the nucleoplasm to the cytoplasm (PubMed:19737519, PubMed:20542003). Activates the GTPase activity of NOG2, which disengages from the pre-60S particle upon GTP hydrolysis, thus freeing its binding site for the nuclear export factor NMD3 (PubMed:24240281).
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.
messages: The protein has several distinct domains, an N-terminal extension (35 kDa), followed by an ATPase domain containing a hexameric ring of six tandem AAA protomers (between 28 and 40 kDa each), a linker domain (260 kDa), an Asp/Glu-rich domain (approximately 70 kDa) and a C-terminal VWFA domain (30 kDa) that possesses a MIDAS (metal ion-dependent adhesion site). The ring-like ATPase head domain associates with the RIX1 complex on the pre-ribosome, while the flexible tail protrudes from the molecule.
messages: nucleolus
messages: nucleoplasm

559292:YMR294W
gene id: 559292:YMR294W
uniprot id: P36224
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the dynactin complex composed of at least ARP1, JNM1, NIP100 and ARP10. Dynactin comprises a short rod of ARP1 polymers attached to ARP10 at its pointed-end and probably associated with the capping protein at its barbed-end. The rod structure is implicated in dynein cargo binding. A sidearm formed by NIP100 projects from the ARP1 filament and is implicated in motor binding (By similarity). Interacts with ARP1.
messages: Component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. JNM1 is associated with the rod and links it to the projecting sidearm. Required for proper nuclear migration during the mitotic cell cycle and for astral microtubule development.
messages: cytoskeleton

559292:YPR009W
gene id: 559292:YPR009W
uniprot id: Q12286
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUT1 family.
messages: Nucleus
messages: Putative transcription factor involved in the regulation of the activity of the cAMP/protein kinase A pathway. Involved in sterol uptake.

559292:YLR021W
gene id: 559292:YLR021W
uniprot id: Q07951
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PSMG3 family.
messages: Component of the 20S proteasome chaperone. Forms a heterodimer with POC4 that binds to proteasome precursors. Interacts with POP2.
messages: Involved in 20S proteasome assembly, facilitating the alpha-ring formation.
messages: Present with 1820 molecules/cell in log phase SD medium.

559292:YLR410W-B
gene id: 559292:YLR410W-B
uniprot id: P0C2J3
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YLR410W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YDL175C
gene id: 559292:YDL175C
uniprot id: Q12476
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AIR1 family.
messages: Component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. AIR2 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1.
messages: Component of the TRAMP complex (also called TRF4 complex) composed of at least HUL4, MTR4, PAP2/TRF4 and either AIR1 or AIR2. Interacts with HMT1 and NPL3. The interaction with NPL3 requires the presence of HMT1. Interacts directly with PAP2.
messages: Nucleus
messages: Present with 1800 molecules/cell in log phase SD medium.

559292:YGR068C
gene id: 559292:YGR068C
uniprot id: P53244
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the arrestin family.
messages: Interacts with RSP5.
messages: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
messages: Present with 1970 molecules/cell in log phase SD medium.
messages: Ubiquitinated by RSP5.

559292:YLR292C
gene id: 559292:YLR292C
uniprot id: P39742
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as non-essential component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC72 may be involved in signal peptide recognition for a defined subset of leader peptides, or may increase the efficiency of unusual or 'difficult' secretory precursors to the translocation pore, it may be that this protein binds charged leader peptides to the membrane until they engage the translocation apparatus.
messages: Component of the heterotetrameric Sec62/63complex composed of SEC62, SEC63, SEC71 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. May interact with protein YLR301W. Part of a complex consisting of KAR2, SEC63, SEC66 and SEC72.
messages: Cytoplasm
messages: Present with 5290 molecules/cell in log phase SD medium.

559292:YOR315W
gene id: 559292:YOR315W
uniprot id: Q12507
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable transcription factor required for superficial pseudohyphal development in response to nitrogen starvation.

559292:YJL082W
gene id: 559292:YJL082W
uniprot id: P47031
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IML2 family.
messages: Cytoplasm
messages: Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
messages: Interacts with lipid droplet proteins PET10 and PDR16.
messages: Nucleus
messages: Present with 4980 molecules/cell in log phase SD medium.

559292:YHR109W
gene id: 559292:YHR109W
uniprot id: P38818
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Methyltransferase which mediates trimethylation of 'Lys-78' of cytochrome c (CYC1).
messages: Present with 2940 molecules/cell in log phase SD medium.
messages: The SET-like region, although related with the SET domain is not detected by any prediction method.
messages: cytosol

559292:YPL139C
gene id: 559292:YPL139C
uniprot id: Q03010
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: By glucose.
messages: Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Component of the RPD3C(S) complex composed of at least EAF3, RCO1, RPD3, SIN3, and UME1. Interacts with RPD3.
messages: Cytoplasm
messages: Nucleus
messages: Present with 3040 molecules/cell in log phase SD medium.
messages: The NEE-box motif is required for the association to RPD3.

559292:YPR082C
gene id: 559292:YPR082C
uniprot id: Q06819
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DIM1 family.
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.
messages: Nucleus

559292:YIL129C
gene id: 559292:YIL129C
uniprot id: P40468
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Associates with CBK1.
messages: Present with 206 molecules/cell in log phase SD medium.
messages: Seems to play a role in cell morphogenesis.
messages: To S.pombe mor2.

559292:YAL064C-A
gene id: 559292:YAL064C-A
uniprot id: Q6B2U8
names: Disruption Phenotype
names: Similarity
messages: Belongs to the flocculin family.
messages: Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.

559292:YMR034C
gene id: 559292:YMR034C
uniprot id: Q05131
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Bud neck
messages: Cell membrane
messages: Expression is positively regulated by calcium/calcineurin signaling through the sole CDRE element (5'-TTAGCCTC-3') in its promoter.
messages: Solute carrier protein that negatively regulates the cytosolic calcium homeostasis in response to high levels of extracellular calcium.

559292:YNL212W
gene id: 559292:YNL212W
uniprot id: P40157
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VID27 family.
messages: Cytoplasm
messages: Has a role in the negative regulation of gluconeogenesis. Required for vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase).
messages: Present with 3500 molecules/cell in log phase SD medium.

559292:YNL022C
gene id: 559292:YNL022C
uniprot id: P53972
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Altered structural conformation of the ribosome in close proximity to cytosine 2278 (m5C2278) in 25S rRNA, leading to impaired translational fidelity, and promote recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Interacts with TRM112.
messages: Present with 922 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2278 (m5C2278) in 25S rRNA (PubMed:23913415, PubMed:25125595, PubMed:25635753). Loss of m5C2278 in 25S rRNA results in anisomycin hypersensitivity (PubMed:23913415).
messages: nucleolus

559292:YOL094C
gene id: 559292:YOL094C
uniprot id: P40339
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair.
messages: Nucleus
messages: Present with 2760 molecules/cell in log phase SD medium.
messages: Replication factor C (RFC) is a heteropentamer of subunits RFC1, RFC2, RFC3, RFC4 and RFC5 and forms a complex with POL30/PCNA in the presence of ATP. Component of the RAD24-RFC complex which consists of RAD14, RFC2, RFC3, RFC4 and RFC5 and associates with the checkpoint clamp DDC1:MEC3:RAD17 complex. Component of the ELG1-RFC complex which consists of ELG1, RFC2, RFC3, RFC4 and RFC5. Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. RFC4 interacts with ECO1.

559292:YAR020C
gene id: 559292:YAR020C
uniprot id: P39545
names: Caution
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Has a stop codon at position 56, which shortens the ORF when compared to other seripauperin family members.

559292:YPR028W
gene id: 559292:YPR028W
uniprot id: Q12402
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DP1 family.
messages: Cells have more than three vacuoles with a grape-like assembly.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Oligomer (PubMed:18442980). Interacts with YIP1 (PubMed:11278413).
messages: Present with 1759 molecules/cell in log phase SD medium.
messages: Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole (PubMed:25646439, PubMed:32432369). Induces high curvature in membranes and causes membrane tubule formation (Probable). Involved in membrane/vesicle trafficking (PubMed:12427979).
messages: The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.

559292:YMR046C
gene id: 559292:YMR046C
uniprot id: Q04215
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-MR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YHR203C
gene id: 559292:YHR203C
uniprot id: P0CX35
uniprot id: P0CX36
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS4 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 102000 molecules/cell in log phase SD medium.
messages: Present with 573 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS4 in yeast.

559292:YOL142W
gene id: 559292:YOL142W
uniprot id: Q08285
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:17173052 and PubMed:17174896, only DIS3/RRP44 subunit of the exosome core has exonuclease activity.
messages: Belongs to the RRP40 family.
messages: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure.
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP40 as peripheral part of the Exo-9 complex is thought to stabilize the hexameric ring of RNase PH-domain subunits.
messages: Present with 6050 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR444W
gene id: 559292:YDR444W
uniprot id: Q04093
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the putative lipase ROG1 family.
messages: Cytoplasm
messages: Present with 2070 molecules/cell in log phase SD medium.

559292:YOR287C
gene id: 559292:YOR287C
uniprot id: Q12481
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles. Interacts with CKA1, CKA2, CKB1, CKB2, PWP2, UTP15, UTP17 and UTP22.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

559292:YHR214W
gene id: 559292:YHR214W
uniprot id: P0CX18
uniprot id: P0CX19
names: Subcellular Location Annotation
messages: Cell membrane

559292:YOR030W
gene id: 559292:YOR030W
uniprot id: Q99234
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Involved in invasion during filamentous growth.
messages: Membrane
messages: Repressed by zinc.

559292:YDR096W
gene id: 559292:YDR096W
uniprot id: Q03833
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Induced upon nutrient starvation.
messages: Nucleus
messages: Present with 432 molecules/cell in log phase SD medium.
messages: Transcription factor involved in the regulation of gene expression upon nutrient starvation. Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region. Can act as a transcriptional activator (e.g. of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e.g. of pyrophosphate phosphatase DPP1). GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1.

559292:YOR144C
gene id: 559292:YOR144C
uniprot id: Q12050
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELG1 family.
messages: Component of the ELG1-RFC complex which consists of ELG1, RFC2, RFC3, RFC4 and RFC5.
messages: Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair.
messages: Nucleus
messages: telomere

559292:YJL184W
gene id: 559292:YJL184W
uniprot id: P46984
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulates in response to hyperosmostic conditions.
messages: Belongs to the GON7 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Nucleus
messages: Present with 2180 molecules/cell in log phase SD medium.
messages: telomere

559292:YJR139C
gene id: 559292:YJR139C
uniprot id: P31116
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the homoserine dehydrogenase family.
messages: Homodimer.
messages: Present with 48900 molecules/cell in log phase SD medium.

559292:YDL243C
gene id: 559292:YDL243C
uniprot id: Q07747
names: Induction
names: Similarity
messages: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
messages: By oxidative stress.

559292:YDL008W
gene id: 559292:YDL008W
uniprot id: Q12157
names: Function
names: Miscellaneous
names: Subunit
messages: Present with 377 molecules/cell in log phase SD medium.
messages: Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. APC11 is required to recruit the ubiquitin-conjugating enzyme E2 to the APC/C.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1.

559292:YML101C
gene id: 559292:YML101C
uniprot id: Q04201
names: Domain
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Present with 1850 molecules/cell in log phase SD medium.
messages: The CUE domain binds ubiquitin, which may facilitate intramolecular monoubiquitination.
messages: Ubiquitinated.

559292:YLR026C
gene id: 559292:YLR026C
uniprot id: Q01590
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane
messages: Interacts with SLY1, STF1, SFB3 and GOS1.
messages: Membrane
messages: Present with 300 molecules/cell in log phase SD medium.
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE).

559292:YNL167C
gene id: 559292:YNL167C
uniprot id: Q02100
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Binds to the CRE motif 5'-TGACGTCA-3' and acts as a repressor of transcription of the SUC2 gene and most probably other genes.
messages: Nucleus
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YGL203C
gene id: 559292:YGL203C
uniprot id: P09620
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S10 family.
messages: Present with 8550 molecules/cell in log phase SD medium.
messages: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from the precursors of K1, K2 and K28 killer toxins and a-factor (mating pheromone). Involved in the programmed cell death caused by defective N-glycosylation and contributes also to the active cell death program induced by acetic acid stress or during chronological aging. Promotes cell fusion by proteolytically processing substrates that act in parallel to PRM1 as an alternative fusion machine, as cell wall components, or both.
messages: trans-Golgi network membrane

559292:YOR289W
gene id: 559292:YOR289W
uniprot id: Q12012
names: Miscellaneous
messages: Present with 1710 molecules/cell in log phase SD medium.

559292:YML007C-A
gene id: 559292:YML007C-A
uniprot id: Q3E7A6
names: Subcellular Location Annotation
messages: Mitochondrion

559292:YLR071C
gene id: 559292:YLR071C
uniprot id: P19263
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins.
messages: Nucleus
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YER012W
gene id: 559292:YER012W
uniprot id: P22141
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity.
messages: Nucleus
messages: Present with 21800 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

559292:YLR117C
gene id: 559292:YLR117C
uniprot id: Q12309
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NTC complex (or PRP19-associated complex), composed of at least CEF1, CLF1, ISY1, NTC20, SNT309, SYF1, SYF2, and PRP19. The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex (or CEF1-associated complex) reminiscent of a late-stage spliceosome composed also of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, LEA1, MSL1, PRP8, PRP9, PRP11, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNU114, SPP2, RSE1 and YJU2. Interacts with CEF1, ISY1, MUD2, NTC20, PRP22, PRP40, PRP46, SYF1, SYF2, and the ORC2 subunit of the origin recognition complex.
messages: Belongs to the crooked-neck family.
messages: Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly by promoting the functional integration of the U4/U6.U5 tri-snRNP particle into the U1-, U2-dependent pre-spliceosome. Also recruits PRP19 to the spliceosome, as a component of the NTC complex (or PRP19-associated complex). The association of the NTC complex to the spliceosome mediates conformational rearrangement or stabilizes the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Required for initiation of the DNA replication by binding the RNA replication origins, probably through its interaction with the origin recognition complex (ORC).
messages: Nucleus
messages: Present with 2140 molecules/cell in log phase SD medium.

559292:YNL244C
gene id: 559292:YNL244C
uniprot id: P32911
names: Function
names: Similarity
names: Subunit
messages: Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.
messages: Belongs to the SUI1 family.
messages: The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. Interacts with NIP1.

559292:YKR069W
gene id: 559292:YKR069W
uniprot id: P36150
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Siroheme synthase involved in methionine biosynthesis.

559292:YHR189W
gene id: 559292:YHR189W
uniprot id: P38876
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH family.
messages: Mitochondrion
messages: Peptidyl-tRNA hydrolase involved in the recycling of tRNA-Lys from diacetyl-lysyl-tRNA-Lys and is important for mitochondrial function.
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YLR345W
gene id: 559292:YLR345W
uniprot id: Q06137
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expression is under the control of the RFX1 transcription factor.
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Present with 3380 molecules/cell in log phase SD medium.
messages: Synthesis and degradation of fructose 2,6-bisphosphate.

559292:YHR101C
gene id: 559292:YHR101C
uniprot id: P38813
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: N-glycosylated.
messages: Present with 3460 molecules/cell in log phase SD medium.
messages: Required for normal beta-1,6-glucan synthesis.

559292:YKL035W
gene id: 559292:YKL035W
uniprot id: P32861
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.
messages: Present with 17200 molecules/cell in log phase SD medium.

559292:YDL070W
gene id: 559292:YDL070W
uniprot id: Q07442
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the TFIID subunit TAF7 and with histone H4.
messages: Nucleus
messages: Phosphorylated by the casein kinase CK2 complex.
messages: Present with 2930 molecules/cell in log phase SD medium.
messages: Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).

559292:YNL145W
gene id: 559292:YNL145W
uniprot id: P34166
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A.

559292:YPL106C
gene id: 559292:YPL106C
uniprot id: P32589
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Has a calcium-dependent calmodulin-binding activity. Required for normal growth at various temperatures.
messages: Increases a few-fold upon upshift to 37 degrees Celsius.
messages: Present with 71700 molecules/cell in log phase SD medium.

559292:YJR094C
gene id: 559292:YJR094C
uniprot id: P21190
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UME6.
messages: Nucleus
messages: Starvation of yeast cells may stimulate activity of IME1 through a post-translational mechanism.
messages: Transcription factor required for sporulation and for early sporulation-specific genes expression. Positive regulator of SME1/IME2 expression. Directly activates expression of SLZ1 during meiosis.

559292:YBR240C
gene id: 559292:YBR240C
uniprot id: P38141
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Positive regulator of thiamine biosynthesis.

559292:YEL019C
gene id: 559292:YEL019C
uniprot id: P38632
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an E3 ligase mediating SUMO/Smt3 attachment to SMC5 and YKU70. Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE2 family.
messages: Component of the Smc5-Smc6 complex which consists of KRE29, NSE1, NSE2/MMS21, NSE3, NSE4, NSE5, SMC5 and SMC6.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2800 molecules/cell in log phase SD medium.

559292:YDR354W
gene id: 559292:YDR354W
uniprot id: P07285
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA), the second step in tryptophan biosynthesis.
messages: Present with 1760 molecules/cell in log phase SD medium.

559292:YEL061C
gene id: 559292:YEL061C
uniprot id: P27895
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
messages: Mitochondrion
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediated by KAR3.
messages: spindle

559292:YPL125W
gene id: 559292:YPL125W
uniprot id: Q02932
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, RAN-dependent mechanism. Required for nuclear import of Ho endonuclease and RFP1, and involved in rRNA-processing and assembly or export of 60S ribosomal subunits.
messages: Interacts with GTP-bound GSP1 and RFP1. Associates with the nuclear pore complex.
messages: Nucleus
messages: Present with 6300 molecules/cell in log phase SD medium.

559292:YIL029C
gene id: 559292:YIL029C
uniprot id: P40538
names: Subcellular Location Annotation
messages: Membrane

559292:YGR206W
gene id: 559292:YGR206W
uniprot id: P42939
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of STP22, VPS28, SRN2 and MVB12 in a 1:1:1:1 stoichiometry. Interacts with STP22 and SRN2.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Appears to be involved in cargo sorting and release of the ESCRT-I complex from the MVBs.
messages: Cytoplasm
messages: Endosome
messages: Late endosome membrane
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YJR017C
gene id: 559292:YJR017C
uniprot id: P22696
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PpiC/parvulin rotamase family.
messages: Cytoplasm
messages: Essential PPIase specific for phosphoserine and phosphothreonine N-terminal to the proline residue. Required for efficient pre-mRNA 3'-end processing and transcription termination, probably by inducing conformational changes by proline-directed isomerization in the C-terminal domain (CTD) of RPB1, thereby altering cofactor binding with the RNA polymerase II transcription complex. Also targets the SIN3-RPD3 histone deacetylase complex (HDAC).
messages: Inhibited by 5-hydroxy-1,4-naphthoquinone (juglone), but not by FK506 or cyclosporin A.
messages: Interacts with the RNA polymerase II largest subunit (RPB1) and with the SIN1-RDP3 HDAC subunit SIN3.
messages: Nucleus
messages: Present with 4401 molecules/cell in log phase SD medium.
messages: The WW domain binds to the phosphorylated tandem 7 residues repeats of RPB1.

559292:YBR094W
gene id: 559292:YBR094W
uniprot id: P38254
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Cytoplasm
messages: P-body
messages: Present with 1770 molecules/cell in log phase SD medium.
messages: Probable P-body-associated tubulin--tyrosine ligase.

559292:YLR410W
gene id: 559292:YLR410W
uniprot id: Q06685
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Although related to histidine acid phosphatase proteins, it lacks the conserved active sites, suggesting that it has no phosphatase activity.
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17412958). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity). Required for maintaining cellular integrity, normal growth and interactions with the ARP complex (PubMed:10388810). Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability (PubMed:17412959). Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth (PubMed:10388810). Regulates polarized growth and modulates interphase microtubule cytoskeleton. Regulates microtubule dynamics without the requirement of microtubule plus-end tracking protein Mal3. Required for growth zone selection (By similarity).
messages: Cytoplasm
messages: Present with 8810 molecules/cell in log phase SD medium.
messages: The N-terminal kinase domain produces inositol polyphosphates. The C-terminal acid phosphatase-like domain binds inositol polyphosphates and negatively regulates their accumulation. The C-terminal domain reduces the amount of inositol pyrophosphates in a dose-dependent manner in vitro.
messages: cytoskeleton

559292:YGR128C
gene id: 559292:YGR128C
uniprot id: P53276
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with snoRNA U3. Interacts with MPP10 and UTP25. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Also has a role in nuclear tRNA export. It acts between the steps of tRNA maturation/aminoacylation and its subsequent translocation out of the nucleus. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
messages: Present with 16800 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YPL121C
gene id: 559292:YPL121C
uniprot id: P32489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFR1/MEI5 family.
messages: Forms a ternary complex with DMC1 and SAE3.
messages: Involved in meiotic DNA-break repair. Required for the recruitment of DCM1 to meiosis recombination hot spots.
messages: Nucleus

559292:YPR113W
gene id: 559292:YPR113W
uniprot id: P06197
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the synthesis of phosphatidylinositol (PtdIns).
messages: Divalent metal cations; Mn(2+) or Mg(2+).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: Myo-inositol-containing phospholipids are of crucial importance in the control of cellular functions.
messages: Present with 3810 molecules/cell in log phase SD medium.

559292:YMR061W
gene id: 559292:YMR061W
uniprot id: P25298
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the CFIA complex, which is composed of RNA14, RNA15, PCF11 and CLP1. Interacts with FIP1, PFS2, YSH1 and probably also with RNA15. Probably interacts with the phosphorylated CTD domain of RPB1/RNA polymerase II.
messages: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with the cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex.
messages: Cytoplasm
messages: Nucleus
messages: Present with 5350 molecules/cell in log phase SD medium.

559292:YMR029C
gene id: 559292:YMR029C
uniprot id: Q05040
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Participates in the control of the reentry into the cell cycle following pheromone treatment.
messages: Present with 4010 molecules/cell in log phase SD medium.

559292:YFR040W
gene id: 559292:YFR040W
uniprot id: P43612
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the SIT4 protein phosphatase catalytic subunit in a cell-cycle-dependent manner.
messages: Belongs to the SAPS family.
messages: Cytoplasm
messages: Hyperphosphorylated in the absence of SIT4.
messages: Positive regulator of protein phosphatase SIT4. Involved in directing expression of TOR-repressed genes and in dephosphorylation of NPR1 in response to nutrient starvation. Negatively modulates K(+) efflux of the cell by the Na(+)-K(+)/H(+) antiporter NHA1.
messages: Present with 5960 molecules/cell in log phase SD medium.

559292:YMR107W
gene id: 559292:YMR107W
uniprot id: Q04438
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the SPG4 family.
messages: Present with 259 molecules/cell in log phase SD medium.
messages: Stationary phase-essential protein not required for growth on nonfermentable carbon sources.

559292:YHR057C
gene id: 559292:YHR057C
uniprot id: P23285
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
messages: Cyclosporin A (CsA) inhibits CYPB.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Present with 339 molecules/cell in log phase SD medium.
messages: Secreted

559292:YLR423C
gene id: 559292:YLR423C
uniprot id: Q06410
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophagy-specific protein that functions with ATG13, ATG29, and CIS1/ATG31 in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles, through interacting with and regulating ATG1 kinase activity. Plays particularly a role in pexophagy and nucleophagy. With ATG13, is required for ATG1 activation by autophosphorylation of 'Thr-226'. Recruits ATG9 to the pre-autophagosomal structure. Also plays a role in regulation of filamentous growth.
messages: Belongs to the ATG17 family.
messages: Cytoplasm
messages: Forms a complex with ATG13, ATG29 and CIS1/ATG31. The ATG17-ATG29-ATG31 complex interacts with the ATG1-ATG13 complex. Forms a complex with SNX4 and ATG20. Interacts with ATG11 and the conserved oligomeric Golgi (COG) complex subunits COG1, COG3 and COG4.
messages: Preautophagosomal structure membrane
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YHR175W
gene id: 559292:YHR175W
uniprot id: P38865
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Homomultimer.
messages: Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.
messages: Vacuole membrane

559292:YHR119W
gene id: 559292:YHR119W
uniprot id: P38827
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: Chromosome
messages: Component of the COMPASS (Set1C) complex which consists of SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and SWD3(1). Interacts with MEC3.
messages: Nucleus
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YKR098C
gene id: 559292:YKR098C
uniprot id: P36026
names: Similarity
messages: Belongs to the peptidase C19 family.

559292:YOR293W
gene id: 559292:YOR293W
uniprot id: Q08745
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS10 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS10 plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation (PubMed:25437641).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). eS10 interacts with GCN1 (via middle region); this interaction is direct and promotes GCN2 kinase activity (PubMed:25437641).
messages: Cytoplasm
messages: Present with 54100 molecules/cell in log phase SD medium.
messages: The N-terminus is not modified.
messages: There are 2 genes for eS10 in yeast.

559292:YGR098C
gene id: 559292:YGR098C
uniprot id: Q03018
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the MCD1/SCC1 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/PDS1 protein. It also promotes anaphase spindle elongation. A component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Cleaves SLK19.
messages: Cytoplasm
messages: It is inactivated via its interaction with PDS1, which probably covers its active site. PDS1 degradation at anaphase, liberates it and triggers MCD1 cleavage.
messages: May bind calcium. Interacts with PDS1. Interacts with MCD1.
messages: Nucleus
messages: spindle pole body

559292:YOR238W
gene id: 559292:YOR238W
uniprot id: Q08634
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 892 molecules/cell in log phase SD medium.

559292:YDR016C
gene id: 559292:YDR016C
uniprot id: Q12248
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD1 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: Present with 799 molecules/cell in log phase SD medium.
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle

559292:YOL016C
gene id: 559292:YOL016C
uniprot id: P22517
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Important in cellular regulation.
messages: Multimeric.
messages: Present with 7500 molecules/cell in log phase SD medium.

559292:YEL066W
gene id: 559292:YEL066W
uniprot id: P39979
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autoacetylates in an intermolecular reaction.
messages: Belongs to the acetyltransferase family. GNAT subfamily.
messages: Cytoplasm
messages: N-acetyltransferase that acetylates histone H4 at 'Lys-8'. Also acetylates polyamines like putrescine, spermidine and spermine (PubMed:23775086). Acts on a wide range of D-amino acids. Catalyzes the N-acetylation through an ordered bi-bi mechanism, in which acetyl-CoA is the first substrate to be bound and CoA is the last product to be liberated (PubMed:15375647). D-amino acids are toxic for the cell and their N-acetylation, preceding removal from cells, plays an important role in detoxification of D-amino acids (PubMed:10600387, PubMed:16362288).
messages: Nucleus
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YMR251W
gene id: 559292:YMR251W
uniprot id: Q04806
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB).
messages: Belongs to the GST superfamily. Omega family.
messages: Cytoplasm
messages: Up-regulated by tert-butyl hydroperoxide (t-BOOH) in an MSN2/4-dependent manner.

559292:YOR330C
gene id: 559292:YOR330C
uniprot id: P15801
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-A family.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Involved in the replication of mitochondrial DNA.
messages: Mitochondrion
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YMR019W
gene id: 559292:YMR019W
uniprot id: P50104
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Binds to SIN3.
messages: Nucleus
messages: Present with 98 molecules/cell in log phase SD medium.

559292:YDL241W
gene id: 559292:YDL241W
uniprot id: Q07738
names: Induction
names: Miscellaneous
messages: Induced under anaerobic conditions.
messages: Present with 1300 molecules/cell in log phase SD medium.

559292:YBR062C
gene id: 559292:YBR062C
uniprot id: P38239
names: Miscellaneous
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YER164W
gene id: 559292:YER164W
uniprot id: P32657
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. It recognizes H3K4me. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. Acts in opposition to the FACT complex in regulating polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the pol I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9. Interacts with RTF1, SPT5 and with the FACT subunits POB3 and SPT16.
messages: Nucleus
messages: Present with 1620 molecules/cell in log phase SD medium.
messages: The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
messages: The CHD1 helical C-terminal domain (CHCT) binds DNA and nucleosomes.

559292:YIL019W
gene id: 559292:YIL019W
uniprot id: P40546
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KRR1.
messages: Required for pre-rRNA processing and 40S ribosomal subunit assembly. Seems to act in the processing of 35S rRNA at the A(0), A(1), and A(2) cleavage sites.
messages: nucleolus

559292:YLL049W
gene id: 559292:YLL049W
uniprot id: Q07887
names: Function
messages: May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.

559292:YPL147W
gene id: 559292:YPL147W
uniprot id: P41909
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Forms a heterodimer with PXA2.
messages: Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix.
messages: Peroxisome membrane

559292:YHR059W
gene id: 559292:YHR059W
uniprot id: P38783
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS41 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). mS41 is involved in telomere length regulation and required for survival upon exposure to K1 killer toxin (PubMed:12663529, PubMed:16552446).
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 2630 molecules/cell in log phase SD medium.

559292:YDR200C
gene id: 559292:YDR200C
uniprot id: Q03944
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
messages: Endoplasmic reticulum membrane
messages: Participates in the control of the reentry into the cell cycle following pheromone treatment. Involved in vacuolar protein sorting.
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YOR262W
gene id: 559292:YOR262W
uniprot id: Q08726
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Cytoplasm
messages: Heterodimers with NPA3/GPN1 or GPN3 (PubMed:21844196, PubMed:23324351). Binds to RNA polymerase II (RNAPII) (By similarity).
messages: Present with 9230 molecules/cell in log phase SD medium.
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import (PubMed:23267056). Required for establishment of sister chromatid cohesion (PubMed:18439903).

559292:YIL093C
gene id: 559292:YIL093C
uniprot id: P40496
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 1920 molecules/cell in log phase SD medium.

559292:YGR161C-C
gene id: 559292:YGR161C-C
uniprot id: P0CX65
uniprot id: P0CX66
uniprot id: P0CX67
uniprot id: P0CX68
uniprot id: P0CX69
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR5 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ER2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-GR3 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-MR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YDR277C
gene id: 559292:YDR277C
uniprot id: P35198
names: Similarity
messages: To yeast STD1/MSN3.

559292:YLR247C
gene id: 559292:YLR247C
uniprot id: Q06554
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: By heat shock and UV radiation.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.
messages: Is probably involved in a pathway contributing to genomic integrity.
messages: Nucleus
messages: Present with 143 molecules/cell in log phase SD medium.

559292:YPL199C
gene id: 559292:YPL199C
uniprot id: Q08954
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 2130 molecules/cell in log phase SD medium.

559292:YDR148C
gene id: 559292:YDR148C
uniprot id: P19262
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: Present with 7970 molecules/cell in log phase SD medium.
messages: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
messages: Transcriptionally regulated by glucose and activated by the HAP2 and HAP3 proteins.

559292:YFL002W-B
gene id: 559292:YFL002W-B
uniprot id: P0CX61
uniprot id: P0CX62
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YOR266W
gene id: 559292:YOR266W
uniprot id: P38969
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with COX18. This interaction may be essential for its insertion into mitochondrial inner membrane.
messages: Mitochondrion inner membrane
messages: Present with 1460 molecules/cell in log phase SD medium.
messages: Probably involved in mitochondrial export. Confers resistance to the anti-pneumocystis carinii drug pentamidine. May act by the removal of pentamidine, or its damage targets, from the matrix by an active-transport mechanism.

559292:YNL099C
gene id: 559292:YNL099C
uniprot id: P50946
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cytoplasm
messages: Present with 2310 molecules/cell in log phase SD medium.
messages: Putative tyrosine-protein phosphatase required for protection against superoxide stress. Involved in cell-cycle delay in response to linoleic acid hydroperoxide (LoaOOH).

559292:YPR103W
gene id: 559292:YPR103W
uniprot id: P30656
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 8530 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib.
messages: The side chain of Thr-76 acts as nucleophile, and the N-terminal amino group acts as proton acceptor.
messages: This subunit is necessary for chymotryptic activity and degradation of ubiquitinated proteins.

559292:YHR166C
gene id: 559292:YHR166C
uniprot id: P16522
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC8/CDC23 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: Nucleus
messages: Phosphorylated by CDC28, which is required for the early mitotic activity of the APC/C in its CDC20-bound form.
messages: Present with 80 molecules/cell in log phase SD medium.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1. CDC23 interacts directly with SWM1 and binds the destruction box (D-box) of the substrate cyclin CLB2.
messages: kinetochore

559292:YBR038W
gene id: 559292:YBR038W
uniprot id: P14180
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (Probable). Required for septum formation (Probable).
messages: Requires proteolytic activation.

559292:YPL245W
gene id: 559292:YPL245W
uniprot id: Q12179
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 1130 molecules/cell in log phase SD medium.

559292:YPR025C
gene id: 559292:YPR025C
uniprot id: P37366
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: CCL1 and KIN28 form the TFIIK complex, a component of TFIIH holo complex. Component of a complex consisting of KIN28, CCL1 and TFB3.
messages: Present with 8700 molecules/cell in log phase SD medium.
messages: Regulatory component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro.

559292:YLR237W
gene id: 559292:YLR237W
uniprot id: Q05998
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane
messages: Present with 3120 molecules/cell in log phase SD medium.
messages: Responsible for intake of thiamine.

559292:YKL029C
gene id: 559292:YKL029C
uniprot id: P36013
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.
messages: Mitochondrion matrix
messages: Present with 10500 molecules/cell in log phase SD medium.

559292:YBR157C
gene id: 559292:YBR157C
uniprot id: P38284
names: Disruption Phenotype
messages: Increases sensitivity to copper.

559292:YDR225W
gene id: 559292:YDR225W
uniprot id: P04911
names: Caution
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1, a component of the NuA4 histone acetyltransferase (HAT) complex, to form H2AK4ac and H2AK7ac.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-106 (H2AQ105me) by NOP1 is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
messages: In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.
messages: N-acetylated by NAT4.
messages: Nucleus
messages: Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A interacts with ARP4, a shared component of the NuA4 histone acetyltransferase complex and the INO80 and SWR1 chromatin remodeling complexes, and serves to recruit first NuA4, mediating histone H4 acetylation, and subsequently the INO80/SWR1 complexes, facilitating DNA resection, to DSB sites. Gamma-H2A is required for sequestering cohesin around the break site, which is important for efficient post-replicative double-strand break repair by homologous recombination, holding the damaged chromatid close to its undamaged sister template. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated by PPH3, a component of the histone H2A phosphatase complex (HTP-C). Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.
messages: Sumoylated to from H2AK126su. May lead to transcriptional repression.
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-5; H2AK7ac = acetylated Lys-8; H2AK126su = sumoylated Lys-127; H2AS128ph = phosphorylated Ser-129.
messages: Transcribed during late G1 and S-phase, repressed in G2.

559292:YLR134W
gene id: 559292:YLR134W
uniprot id: P16467
names: Activity Regulation
names: Biotechnology
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by its substrate, pyruvate.
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cytoplasm
messages: Fusel oils and acyloins are important flavor and aroma compounds in yeast-fermented products contributing to the quality of beverages and food, e.g. fusel oils in whiskey, contrary to common believe, seem to alleviate hangover. In general they are desirable at low concentrations, whereas high concentrations may spoil the product. By adjusting growth conditions and substrate their production is sought to be influenced. Due to their broad substrate tolerance pyruvate decarboxylases are important biocatalysts for chemoenzymatic syntheses, both by fermentation and in vitro, e.g. in the production of ephedrine, vitamin E, or phenylethanol (rose flavor).
messages: Homotetramer.
messages: Nucleus
messages: Present with 471316 molecules/cell in log phase SD medium.
messages: Protein expression is strongly induced by high concentrations of fermentable carbon sources, under anaerobic growth conditions, and by thiamine limitation, but is repressed by the presence of PDC1 (independent of its catalytic activity) and thiamine.
messages: Second most abundant of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids derived from threonine (2-oxobutanoate), norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, also alpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate), and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins.

559292:YMR154C
gene id: 559292:YMR154C
uniprot id: Q03792
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
messages: Interacts with SNF7, which may act together with RIM20 as a scaffold to recruit RIM13 to its substrate RIM101.
messages: Present with 432 molecules/cell in log phase SD medium.
messages: Required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH, which is necessary for sporulation and invasive growth. Probably the protease that cleaves RIM101.

559292:YGR149W
gene id: 559292:YGR149W
uniprot id: P48236
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPC1 family.
messages: Decreases the levels of monounsaturated PC species and increased those of diunsaturated PC species. Does not significantly affect phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine profiles.
messages: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:18430972, PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:18430972, PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859). Involved in postsynthetic PC remodeling that produces more saturated PC species (PubMed:30514764).
messages: Membrane
messages: The GPCAT activity is sensitive to N-ethylmaleimide, phenanthroline, and divalent cations including Ca(2+), Mg(2+), Mn(2+) and Zn(2+) (PubMed:18430972). The activity is also inhibited by glycerol-3-phosphate (G3P) (PubMed:27758859).

559292:YHR113W
gene id: 559292:YHR113W
uniprot id: P38821
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl aminopeptidase that contributes to peptide degradation both in the cytosol and the vacuole. Cells may respond to environmental conditions by changing the distributions of the cytosolic enzyme to the vacuole when cells need more active vacuolar degradation.
messages: Belongs to the peptidase M18 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Present with 172 molecules/cell in log phase SD medium.
messages: Tetrahedron-shaped homododecamer built from six homodimers.
messages: The metalloproteases inhibitors EDTA and 1.10-phenanthroline both inhibit the activity, whereas bestatin, an inhibitor of most aminopeptidases, does not affect enzyme activity.
messages: Vacuole lumen

559292:YDR424C
gene id: 559292:YDR424C
uniprot id: Q02647
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Also a component of the nuclear pore complex where it may contribute to the stable association of the Nup82 subcomplex with the NPC (PubMed:17546040, PubMed:23223634, PubMed:25646085).
messages: Belongs to the dynein light chain family.
messages: Homodimer (PubMed:17546040, PubMed:23223634, PubMed:25646085). Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Component of the nuclear pore complex (NPC) (PubMed:17546040). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof (PubMed:17546040). Part of the NUP82 subcomplex (PubMed:17546040, PubMed:25646085, PubMed:23223634). In the complex, interacts directly with Nup159 (PubMed:17546040, PubMed:25646085, PubMed:23223634).
messages: Present with 1310 molecules/cell in log phase SD medium.
messages: cytoskeleton
messages: nuclear pore complex

559292:YML087C
gene id: 559292:YML087C
uniprot id: Q04516
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Increases frequency of mitochondrial genome loss.
messages: Membrane

559292:YGR267C
gene id: 559292:YGR267C
uniprot id: P51601
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
messages: Homodimer.
messages: Leads to folinic acid auxotrophy, and lacks any detectable specific enzymatic activity.
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YPR192W
gene id: 559292:YPR192W
uniprot id: P0CD91
names: Developmental Stage
names: Domain
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in spores.
messages: In strain S288c and many other laboratory strains, a natural frameshift in position 294 results in a shortened C-terminus when compared to wild-type alleles. It is however not the different C-terminus, but rather 2 polymorphisms at positions 121 and 255 that lead to loss of water transport activity.
messages: Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains.

559292:YKL023W
gene id: 559292:YKL023W
uniprot id: P36103
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 1730 molecules/cell in log phase SD medium.

559292:YAL041W
gene id: 559292:YAL041W
uniprot id: P11433
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts with AXL2.
messages: Present with 1010 molecules/cell in log phase SD medium.
messages: Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site.

559292:YGR147C
gene id: 559292:YGR147C
uniprot id: P37293
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterooligomeric.
messages: Maybe involved in N-terminal acetylation of proteins. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.
messages: Present with 1240 molecules/cell in log phase SD medium.

559292:YOL052C
gene id: 559292:YOL052C
uniprot id: P21182
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine, a key step in the biosynthetic pathway for spermidine and spermine. It is essential for normal growth, sporulation, and maintenance of ds-RNA virus.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Present with 7060 molecules/cell in log phase SD medium.

559292:YDR137W
gene id: 559292:YDR137W
uniprot id: P16664
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RGP1 family.
messages: Forms a complex with RIC1.
messages: Golgi apparatus
messages: Present with 589 molecules/cell in log phase SD medium.
messages: Required for proper mitotic growth.
messages: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment.

559292:YMR176W
gene id: 559292:YMR176W
uniprot id: Q03214
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: May be involved in cell wall organization and biogenesis.
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YLR010C
gene id: 559292:YLR010C
uniprot id: Q07921
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.
messages: Interacts with CDC13 and STN1.
messages: Nucleus
messages: telomere

559292:YHR011W
gene id: 559292:YHR011W
uniprot id: P38705
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Homodimer. The tRNA molecule binds across the dimer (By similarity).
messages: Mitochondrion matrix
messages: Present with 405 molecules/cell in log phase SD medium.

559292:YOR165W
gene id: 559292:YOR165W
uniprot id: Q99287
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: By salt stress.
messages: Cooperates with the reticulon proteins RTN1 and RTN2 and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.
messages: Endoplasmic reticulum membrane
messages: Interacts with RTN1 and YOP1; GTP binding is not required for these interactions.
messages: Present with 2265 molecules/cell in log phase SD medium.

559292:YLR299W
gene id: 559292:YLR299W
uniprot id: Q05902
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is decreased by glutathione and ammonium ion.
messages: Belongs to the gamma-glutamyltransferase family.
messages: Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides. Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH. Plays a role in the turnover of the vacuolar GSH, serving as an alternative nitrogen source during nitrogen starvation.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: Heterodimer composed of a light and a heavy chain. The active site is located in the light chain.
messages: Induced upon nitrogen starvation. Repressed by ammonium ions. 6-diazo-5-oxo-L-norleucine and L-azaserine are irreversible inhibitors whereas serine-borate is a reversible inhibitor.
messages: Present with 672 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YOR097C
gene id: 559292:YOR097C
uniprot id: Q12274
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YBR298C-A
gene id: 559292:YBR298C-A
uniprot id: Q8TGK4
names: PTM
messages: N-glycosylated.

559292:YHR001W
gene id: 559292:YHR001W
uniprot id: P38755
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSBP family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with the AAA ATPase VPS4; regulates OSH7 membrane association. VPS4 is required for membrane dissociation of OSH7.
messages: Present with 2350 molecules/cell in log phase SD medium.
messages: The OSBP-related domain (ORD) mediates binding of sterols and phospholipids. It displays an incomplete beta-barrel containing a central hydrophobic tunnel that can accommodate a single lipid molecule with a flexible lid covering the tunnel entrance. The ORD can bind two membranes simultaneously. It has at least two membrane-binding surfaces; one near the mouth of the lipid-binding pocket and a distal site that can bind a second membrane. These structural features correlate with the phosphatidylinositol 4-phosphate (PI(4)P)-coupled lipid transport optimized in closely apposed membranes, such as organelle contact sites. The lipid transfer cycle starts from the association of the LTP with a donor membrane, which accompanies conformational changes that uncover the ligand-binding pocket. The tunnel opening is generally mediated by displacement of the lid covering the binding pocket allowing uptake or release of a lipid molecule. The LTPs extract the lipid from the membrane by providing a hydrophobic environment as well as specific interaction. Dissociation from the donor membrane shifts the conformation to a closed form. Then, the LTPs loaded with a cargo lipid diffuse through the aqueous phase. Lid opening may be induced by the interaction of a hydrophobic side of the lid with the target membranes.
messages: ipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:15173322). Involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the PM in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/PM interface, SAC1 drives PS transport (PubMed:23934110, PubMed:26206936). Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936).

559292:YDR088C
gene id: 559292:YDR088C
uniprot id: Q02775
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with BRR2, ECM2, PRP18 and PRP22.
messages: Belongs to the SLU7 family.
messages: Essential protein involved in the second catalytic step of pre-mRNA splicing. Involved in the selection of 3'-type splice sites; this selection could be done via a 3'-splice site-binding factor, PRP16.
messages: N-glycosylated.
messages: Nucleus
messages: Present with 1490 molecules/cell in log phase SD medium.
messages: The CCHC-type zinc finger probably plays a role in the ability of SLU7 to bypass the requirement for PRP18.

559292:YGR075C
gene id: 559292:YGR075C
uniprot id: Q00723
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Nucleus
messages: Present with 2380 molecules/cell in log phase SD medium.
messages: Required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Implicated in the formation of stable and biologically active snRNP structures. As part of the U4/U6.U5 tri-snRNP particle, dispensible for spliceosome assembly, but required for conformational changes, which result in U4 snRNA release and the subsequent catalytic activation of the spliceosome.

559292:YGL014W
gene id: 559292:YGL014W
uniprot id: P25339
names: Function
names: Miscellaneous
messages: Is not essential for haploid growth, but may affect diploid formation.
messages: Present with 721 molecules/cell in log phase SD medium.

559292:YDR476C
gene id: 559292:YDR476C
uniprot id: Q03362
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Present with 2120 molecules/cell in log phase SD medium.

559292:YGR031C-A
gene id: 559292:YGR031C-A
uniprot id: Q8TGN9
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is dependent upon the presence of the cell wall integrity pathway mitogen-activated protein kinase SLT2 and its downstream transcription factor RLM1.
messages: Hypersensitive to cell wall-perturbing agent calcofluor white (CFW) at 37 degrees Celsius. A similar phenotype is observed at 30 degrees Celsius, although the severity is decreased. Decreased expression of genes contributing to cell wall organization during vegetative growth.
messages: Involved in yeast cell wall biogenesis.
messages: Membrane
messages: Overlaps completely with ORF YGR031W.

559292:YPR102C
gene id: 559292:YPR102C
uniprot id: P0C0W9
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). uL5 forms a heterotrimeric complex with uL18/RPL5 and SYO1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer (PubMed:23118189).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Nucleus
messages: Present with 39000 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL5 in yeast.

559292:YOR324C
gene id: 559292:YOR324C
uniprot id: Q99332
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Calcineurin-dependent protein required for growth under high NaCl, alkaline pH and cell wall stress.
messages: Endoplasmic reticulum membrane
messages: Interacts with the 2 calcineurin A subunits CNA1 and CMP2, and with HPH2/FRT2.
messages: Phosphorylated. Is dephosphorylated by calcineurin.
messages: Present with 251 molecules/cell in log phase SD medium.

559292:YOR353C
gene id: 559292:YOR353C
uniprot id: Q08817
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 892 molecules/cell in log phase SD medium.
messages: Required for proper cell morphogenesis and cell separation after mitosis. Functions in the RAM (regulation of ACE2 activity and cellular morphogenesis) signaling network and is required for proper ACE2 localization and CBK1 kinase activity.

559292:YGL116W
gene id: 559292:YGL116W
uniprot id: P26309
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). At the metaphase-to-anaphase transition, recognizes and binds proteins containing a D-box including the B-type cyclins CLB2 and CLB5, HSL1 and securin PDS1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for sister chromatid separation and disassembly of the mitotic spindle. Target of the spindle checkpoint pathway through participation in the mitotic checkpoint complex (MCC) and the MAD2-CDC20 subcomplex. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 until proper attachment of all chromosomes to the spindle.
messages: Belongs to the WD repeat CDC20/Fizzy family.
messages: Component of the mitotic checkpoint complex (MCC) which consists of MAD2, MAD3, BUB3 and CDC20, and of the MAD2-CDC20 subcomplex, both of which appear to be assembled during mitoisis independently of the kinetochore. In mitose-arrested cells, MAD2-CDC20 occurs in a larger amount than MCC. MCC associates with the with the APC/C complex. Interacts with MAD2, MAD3, BUB3, HSL1 and PDS1.
messages: Expressed in late S and M phase of the cell cycle. Degraded in G1 by the APC/C in its CDH1-bound form.
messages: Nucleus
messages: Phosphorylated by CDC28.
messages: The C-box is required for the association with the APC/C complex.
messages: The KEN box is required for the association with the APC/C complex.
messages: The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: Ubiquitinated by the APC/C complex.

559292:YOL166W-A
gene id: 559292:YOL166W-A
uniprot id: Q8TGJ1
names: Similarity
messages: Belongs to the UPF0320 family.

559292:YHL009W-B
gene id: 559292:YHL009W-B
uniprot id: P0C2J7
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-362 and Gly-363 of the YHL009W-A ORF.
messages: Proteolytically processed into capsid protein (CA), Ty4 protease (PR), integrase (IN) and reverse transcriptase/ribonuclease H (RT) proteins (Probable). Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty4 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The protease is a homodimer, whose active site consists of two apposed aspartic acid residues.

559292:YOR308C
gene id: 559292:YOR308C
uniprot id: Q12420
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNU66/SART1 family.
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Interacts with the pre-mRNA-splicing helicase BRR2 and the ubiquitin-like modifier HUB1.
messages: Component of the U4/U6.U5 tri-snRNP particle, one of the building blocks of the spliceosome. Required for pre-mRNA splicing.
messages: Nucleus

559292:YNR065C
gene id: 559292:YNR065C
uniprot id: P53751
names: Subcellular Location Annotation
messages: Membrane

559292:YOR162C
gene id: 559292:YOR162C
uniprot id: Q12172
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor involved in the regulation of multidrug resistance genes. Acts in concert with YRR1.

559292:YPL240C
gene id: 559292:YPL240C
uniprot id: P02829
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Expressed constitutively and induced by high temperatures dependent on transcription factor HSF1. According to PubMed:2674684, it is constitutively expressed at low levels, however, due to the specificity of the antibody, this result is unsure.
messages: Homodimer. Interacts with the co-chaperones AHA1, CDC37, CNS1, CPR6, CPR7, HCH1, SBA1, SSE1 and STI1. CNS1, CPR6, CPR7 and STI1. Interacts directly with the substrates GCN2, HAP1 and STE11.
messages: Inhibited by geldanamycin, macbecin I and radicicol, which bind to the ATP-binding pocket. Co-chaperones CDC37, SBA1 and STI1 reduce ATPase activity. Co-chaperones AHA1 and HCH1 increase ATPase activity.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.
messages: Present with 444943 molecules/cell in log phase SD medium.
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperones AHA1, CDC37, CNS1, CPR6, CPR7, HCH1, SBA1, SSE1 and STI1. CNS1, CPR6, CPR7 and STI1.

559292:YEL064C
gene id: 559292:YEL064C
uniprot id: P39981
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Probable amino acid transporter of unknown specificity.
messages: Vacuole membrane

559292:YGL208W
gene id: 559292:YGL208W
uniprot id: P34164
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Involved in the regulation of aging. Acts as a negative regulator of nuclear SNF1 activity in young cells by sequestering its activating gamma subunit at the plasma membrane.
messages: Cell membrane
messages: Component of the SNF1 kinase complex, a heterotrimeric complex composed of the catalytic alpha subunit SNF1, one of the three related beta subunits SIP1, SIP2 or GAL83, and the regulatory gamma subunit SNF4. The beta subunit serves as a bridge between the catalytic and the regulatory subunit. Interacts (via KIS domain) with SNF1. Interacts (via ASC domain) with SNF4.
messages: Cytoplasm
messages: Induced upon shift to nonfermentable carbon sources.
messages: Phosphorylated by SNF1 in vitro.
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YER153C
gene id: 559292:YER153C
uniprot id: P10355
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Present with 468 molecules/cell in log phase SD medium.
messages: Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA.

559292:YJL208C
gene id: 559292:YJL208C
uniprot id: P08466
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA/RNA non-specific endonuclease family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Present with 3870 molecules/cell in log phase SD medium.
messages: The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.
messages: This enzyme has both RNase and DNase activity.

559292:YBR265W
gene id: 559292:YBR265W
uniprot id: P38342
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
messages: Endoplasmic reticulum membrane
messages: Present with 7700 molecules/cell in log phase SD medium.

559292:YPR001W
gene id: 559292:YPR001W
uniprot id: P43635
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Dual specificity mitochondrial citrate and methylcitrate synthase with similar catalytic efficiency with both acetyl-CoA and propionyl-CoA.
messages: Leads to an accumulation of acetate and of isobutanol.
messages: Mitochondrion

559292:YKL033W-A
gene id: 559292:YKL033W-A
uniprot id: Q86ZR7
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Nucleotidase with XMP as the best in vitro substrate. Low catalytic efficiencies of YKL033W-A observed with XMP and other substrates suggest that these could be secondary activities for this protein, and its primary substrate is not yet identified. May possess pseudouridine 5'-phosphatase activity and together with dTTP/UTP pyrophosphatase YOR111W might constitute a pathway for the detoxification of pseudouridine 5'-triphosphate (Psi-UTP) and -monophosphate (Psi-UMP).

559292:YGR247W
gene id: 559292:YGR247W
uniprot id: P53314
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. CPD1 family.
messages: Golgi apparatus
messages: Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:YDL217C
gene id: 559292:YDL217C
uniprot id: Q12328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54, associated with the peripheral proteins MRS5/TIM12 and the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins, such as mitochondrial carrier family members, into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps. Mediates the insertion of precursor proteins in a 3 step process. After the precursor is tethered to the translocase without losing energy from the Delta(psi), 2 energy-requiring steps are needed. First, Delta(psi) acts on the precursor protein and promotes its docking in the translocase complex. Then, Delta(psi) and an internal signal peptide together induce rapid gating transitions in one pore and closing of the other pore and drive membrane insertion to completion.
messages: Mitochondrion inner membrane

559292:YBR291C
gene id: 559292:YBR291C
uniprot id: P38152
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Transport of citrate across inner mitochondrial membrane.

559292:YDL184C
gene id: 559292:YDL184C
uniprot id: P0CX86
uniprot id: P0CX87
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 11900 molecules/cell in log phase SD medium.
messages: Present with 4910 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL41 in yeast.

559292:YLR024C
gene id: 559292:YLR024C
uniprot id: Q07963
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UBR1 family.
messages: Cytoplasm
messages: Deletion produces no detectable phenotype.
messages: E3 ubiquitin-protein ligase which probably functions outside the N-end rule pathway, since it lacks the residues essential for the degradation of N-end rule substrates. Mediates RPN4 ubiquitination and subsequent degradation.
messages: Interacts with MUB1, RPN4 and UBC2.
messages: Present with 49 molecules/cell in log phase SD medium.
messages: The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.

559292:YDR007W
gene id: 559292:YDR007W
uniprot id: P00912
names: Miscellaneous
names: Similarity
messages: Belongs to the TrpF family.
messages: Present with 1850 molecules/cell in log phase SD medium.

559292:YPL231W
gene id: 559292:YPL231W
uniprot id: P19097
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of the Acyl carrier domain by the C-terminal PPT domain. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.
messages: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.
messages: Inhibited by cerulenin by covalent binding to active site of the ketoacyl synthase (KS) region.
messages: Present with 17000 molecules/cell in log phase SD medium.
messages: [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).

559292:YGR135W
gene id: 559292:YGR135W
uniprot id: P23638
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 17100 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

559292:YPL194W
gene id: 559292:YPL194W
uniprot id: Q08949
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDC1 family.
messages: Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17. The interaction with MEC3 is performed in a RAD17-dependent manner. The checkpoint clamp complex loads onto DNA in an ATP-dependent manner through its interaction with the RFC-RAD4 checkpoint clamp loader complex. Interacts with the DNA polymerase zeta subunit REV7 and DPB11.
messages: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated during cell cycle S-phase and in response to DNA damage. This phosphorylation is MEC14 dependent. Also hosphorylated by CDC28.
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YFR026C
gene id: 559292:YFR026C
uniprot id: P43604
names: Function
names: Induction
names: Miscellaneous
messages: By the unfolded protein response (UPR).
messages: Involved in the unfolded protein response (UPR), a transcriptional response which up-regulates genes that enable cells to cope with misfolded, endoplasmic reticulum-retained proteins. UPR is part of the endoplasmic reticulum quality control (ERQC) which prevents the exit of misfolded secretory and membrane proteins from the endoplasmic reticulum.
messages: Present with 721 molecules/cell in log phase SD medium.

559292:YDR221W
gene id: 559292:YDR221W
uniprot id: Q04924
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Heterodimer of a catalytic subunit alpha (ROT2) and a subunit beta (GTB1).
messages: Present with 9760 molecules/cell in log phase SD medium.
messages: Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Specifically required for the cleavage of the final glucose.

559292:YDL109C
gene id: 559292:YDL109C
uniprot id: Q12103
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the putative lipase ROG1 family.
messages: Involved in lipid metabolism.
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YBL085W
gene id: 559292:YBL085W
uniprot id: P38041
names: Function
names: Miscellaneous
messages: Binds to the BEM1 protein.
messages: Present with 1040 molecules/cell in log phase SD medium.

559292:YOR339C
gene id: 559292:YOR339C
uniprot id: P52492
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins.

559292:YDR499W
gene id: 559292:YDR499W
uniprot id: Q04377
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a complex with MEC1.
messages: Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Required for the recruitment of MEC1 to DNA lesions, the activation of CHK1 and RAD53 kinases and phosphorylation of RAD9 in response to DNA damage. Required for cell growth and meiotic recombination.
messages: Nucleus
messages: Phosphorylated by MEC1 in a cell cycle dependent manner and in response to DNA damage.
messages: Present with 606 molecules/cell in log phase SD medium.

559292:YDR324C
gene id: 559292:YDR324C
uniprot id: Q06679
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
messages: Present with 5440 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR178W
gene id: 559292:YDR178W
uniprot id: P37298
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of a large and a small subunit.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH3 and SDH4 form the membrane dimer that anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction.
messages: Mitochondrion inner membrane
messages: Present with 7920 molecules/cell in log phase SD medium.

559292:YLR272C
gene id: 559292:YLR272C
uniprot id: Q06156
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.
messages: Nucleus
messages: Present with 2540 molecules/cell in log phase SD medium.
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.

559292:YOL090W
gene id: 559292:YOL090W
uniprot id: P25847
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer), which bind to DNA mismatches thereby initiating DNA repair. MSH2 seems to act as a scaffold for the other MutS homologs that provide substrate-binding and substrate specificity. When bound, heterodimers bend the DNA helix and shield approximately 20 base pairs. MutS alpha acts mainly to repair base-base and single insertion-deletion mismatches that occur during replication, but can also repair longer insertion-deletion loops (IDLs), although with decreasing efficiency as the size of the extrahelical loop increases. MutS beta acts mainly to repair IDLs from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches. After mismatch binding, MutS alpha or beta form a ternary complex with a MutL heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. Both subunits bind ATP, but with differing affinities, and their ATPase kinetics are also very different. MSH6 binds and hydrolyzes ATP rapidly, whereas MSH2 catalyzes ATP at a substantially slower rate. Binding to a mismatched base pair suppresses MSH6-catalyzed ATP hydrolysis, but not the activity of MSH2. ATP binding to both subunits is necessary to trigger a change in MutS alpha interaction with mismatched DNA, converting MutS alpha into a sliding clamp capable of hydrolysis-independent movement along DNA, and also facilitates formation of ternary complexes containing MutS and MutL proteins and the mismatch. MutS beta also has a role in regulation of heteroduplex formation during mitotic and meiotic recombination. MutS beta binds to DNA flap structures predicted to form during recombination, and is required for 3' non-homologous tail remova…
messages: Heterodimer consisting of MSH2-MSH6 (MutS alpha) or MSH2-MSH3 (MutS beta). Both heterodimers form a ternary complex with MutL alpha (MLH1-PMS1). MutS beta also forms a ternary complex with MutL beta (MLH1-MLH3), and possibly with a MLH1-MLH2 heterodimer. Both heterodimers interact with proliferating cell nuclear antigen (PCNA/POL30). This interaction is disrupted upon binding of the MutS heterodimers to mismatch DNA. Interacts with SAW1.
messages: Inhibited by Cd(2+).
messages: Nucleus
messages: Present with 1230 molecules/cell in log phase SD medium.

559292:YOR193W
gene id: 559292:YOR193W
uniprot id: Q08580
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homooligomer. Interacts with PEX25 and PEX34.
messages: Peroxisome membrane
messages: Present with 382 molecules/cell in log phase SD medium.
messages: Required for regulation of peroxisome size and number. Also promotes peroxisome division and biogenesis.

559292:YOR280C
gene id: 559292:YOR280C
uniprot id: Q99369
names: Function
names: Induction
names: Similarity
messages: Belongs to the AB hydrolase 3 family.
messages: Regulated by RFX1/CRT1.
messages: Serine hydrolase of unknown specificity.

559292:YDR261C-D
gene id: 559292:YDR261C-D
uniprot id: Q07793
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YDR261C-C ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).
messages: Transposon YDRCTy1-3 (YDRCTy1-3) contains a 425 bp deletion at position 1596, which truncates the ORF coding for protein TY1B when compared to other Ty1 elements. It is probably not functional.

559292:YEL076C-A
gene id: 559292:YEL076C-A
uniprot id: P0CX16
uniprot id: P0CX17
names: Caution
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Could be the product of a pseudogene. Although strongly related to DNA helicases, it lacks the helicase domains, suggesting that it has no helicase activity.

559292:YIL095W
gene id: 559292:YIL095W
uniprot id: P40494
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with ABP1, which is required for proper actin patch localization.
messages: Present with 1323 molecules/cell in log phase SD medium.
messages: Protein kinase involved in the regulation of actin cytoskeleton organization and endocytosis (PubMed:9885245, PubMed:10087264, PubMed:11694597, PubMed:11739778). Phosphorylates PAN1 which disrupts the interaction between PAN1 and END3, and between PAN1 and SLA1 (PubMed:9885245, PubMed:11739778, PubMed:13679512). Phosphorylates SCD5 (PubMed:12956961, PubMed:13679512). Preferentially, phosphorylates substrates on threonine residues in a [L/I/V/M]-x-x-[Q/N/T/S]-x-T-G motif (PubMed:9885245, PubMed:11739778, PubMed:12956961, PubMed:13679512).
messages: Viable (PubMed:9885245). At the restrictive temperature of 37 degrees Celsius, loss of asymmetric localization of cortical actin patches and, delay in emergence and bud growth resulting in the accumulation of unbudded cells (PubMed:9885245).
messages: actin patch

559292:YKR077W
gene id: 559292:YKR077W
uniprot id: P36157
names: Miscellaneous
names: Subunit
messages: Interacts with transcription complexes SCB-binding factor (SBF) and MCB-binding factor (MBF). Interacts with SWI4.
messages: Present with 861 molecules/cell in log phase SD medium.

559292:YPL163C
gene id: 559292:YPL163C
uniprot id: Q12254
names: Function
names: Miscellaneous
messages: Present with 688 molecules/cell in log phase SD medium.
messages: Required for vanadate resistance.

559292:YNL222W
gene id: 559292:YNL222W
uniprot id: P53538
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSU72 phosphatase family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. SSU72 is required for 3'-end formation of snoRNAs.
messages: Nucleus
messages: Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).

559292:YKR041W
gene id: 559292:YKR041W
uniprot id: P36134
names: Miscellaneous
messages: Present with 217 molecules/cell in log phase SD medium.

559292:YLR199C
gene id: 559292:YLR199C
uniprot id: Q05778
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Component of the 20S proteasome chaperone. Forms a heterodimer with ADD66 that binds to proteasome precursors.
messages: Cytoplasm
messages: Involved in 20S proteasome assembly.
messages: Present with 1350 molecules/cell in log phase SD medium.

559292:YLL045C
gene id: 559292:YLL045C
uniprot id: P29453
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 80200 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL8 in yeast.

559292:YAL019W
gene id: 559292:YAL019W
uniprot id: P31380
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Chromosome
messages: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs, facilitating single-stranded DNA (ssDNA) production by the EXO1 and SGS1 machinery. Promotes gene silencing at heterochromatin by regulating the chromatin structure within or around silent loci. Also required for heterochromatin organization at centromeres.
messages: Homodimer.
messages: Impaired ability to repair double-strand breaks (DSBs).
messages: Nucleus
messages: Present with 6800 molecules/cell in log phase SD medium.
messages: Was initially reported to contain a CUE domain (PubMed:19956593). However, no CUE domain is predicted by prediction tools and the CUE-like region does not show no affinity for ubiquitinated histones (PubMed:20075079).

559292:YLR004C
gene id: 559292:YLR004C
uniprot id: Q07904
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Allantoate permease family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Induced by limited extracellular thiamine levels.
messages: Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway.

559292:YGR100W
gene id: 559292:YGR100W
uniprot id: P53258
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with MAC1.
messages: Present with 768 molecules/cell in log phase SD medium.
messages: Stimulates specifically the GTPase activity of SEC4, YPT6 and YPT36. Inactivates YPT6 during recycling between the endosome and the Golgi compartments.

559292:YER145C
gene id: 559292:YER145C
uniprot id: P40088
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane
messages: Permease for high affinity iron uptake.
messages: Present with 8370 molecules/cell in log phase SD medium.

559292:YIL143C
gene id: 559292:YIL143C
uniprot id: Q00578
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A C-terminal deletion renders yeast hypersensitive to UV light.
messages: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription (PubMed:8269516, PubMed:7693549, PubMed:7961739, PubMed:8202161, PubMed:7813015, PubMed:8631896). XPB/SSL2 acts as a double-stranded DNA translocase promoting DNA opening by tracking along the nontemplate promoter strand, rotating and inserting DNA into the Pol II active site cleft, leading to DNA unwinding. May also use this translocase mechanism during DNA repair rather than physically wedging open damaged DNA (PubMed:25775526).
messages: Belongs to the helicase family. RAD25/XPB subfamily.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Nucleus
messages: Present with 825 molecules/cell in log phase SD medium.

559292:YER010C
gene id: 559292:YER010C
uniprot id: P40011
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Competitively inhibited by oxalate, a pyruvate enolate analog.
messages: Divalent metal cation. Has preference for nickel ions for the HMG aldolase activity. Has preference for cobalt and zinc ions for the OAA decarboxylase activity.
messages: Homotrimer. Forms a ring-like structure with a central cavity.
messages: Present with 846 molecules/cell in log phase SD medium.

559292:YAL047C
gene id: 559292:YAL047C
uniprot id: P39723
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homooligomer. Interacts with CDC5, KAR1, KIN4, SPC97, SPC98, STU2 and TUB4.
messages: Phosphorylated by CDC5.
messages: Present with 639 molecules/cell in log phase SD medium.
messages: Spindle pole body component that acts as the gamma-tubulin complex-binding protein of the SPB outer plaque. Anchors cytoplasmic microtubules at the at the half bridge of the spindle pole body (SPB) and accordingly functions in nuclear position and spindle orientation, including anaphase spindle migration into the bud. Recruits KIN4 kinase to both SPBs when cytoplasmic microtubules are defective. Links cytoplasmic microtubules with spindle orientation checkpoint (SPOC) components and, therefore, could function as part of the sensors of spindle orientation defects. Is strictly required for mating and karyogamy.
messages: spindle pole body

559292:YOR286W
gene id: 559292:YOR286W
uniprot id: Q08742
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion
messages: Present with 4220 molecules/cell in log phase SD medium.
messages: Thiosulfate sulfurtransferase which catalyzes the transfer of sulfane sulfur from thiosulfate to cyanide.

559292:YDR356W
gene id: 559292:YDR356W
uniprot id: P32380
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPC110 family.
messages: Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth.
messages: Homodimer. Component of the SPC110 complex containing at least CMD1, SPC29 and SCP110. Interacts with SPC97 and SPC98.
messages: Nucleus
messages: Present with 279 molecules/cell in log phase SD medium.
messages: spindle pole body

559292:YER014C-A
gene id: 559292:YER014C-A
uniprot id: P85052
names: Function
messages: Involved in bud site selection. Required for resistance to the DNA-damaging agent methyl methanesulfonate (MMS).

559292:YNR035C
gene id: 559292:YNR035C
uniprot id: P53731
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
messages: Present with 13400 molecules/cell in log phase SD medium.
messages: actin patch

559292:YNL144C
gene id: 559292:YNL144C
uniprot id: P53907
names: Similarity
messages: To yeast YHR131c.

559292:YKL208W
gene id: 559292:YKL208W
uniprot id: P36038
names: Function
names: Subcellular Location Annotation
messages: Involved in 5'-end processing of mitochondrial COB, 15S rRNA, and RPM1 transcript. May also have a role in 3'-end processing of the COB pre-mRNA.
messages: Mitochondrion

559292:YGL026C
gene id: 559292:YGL026C
uniprot id: P00931
names: Miscellaneous
names: Similarity
messages: In the C-terminal section; belongs to the TrpB family.
messages: In the N-terminal section; belongs to the TrpA family.
messages: Present with 15500 molecules/cell in log phase SD medium.

559292:YBL015W
gene id: 559292:YBL015W
uniprot id: P32316
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyl-CoA hydrolase/transferase family.
messages: Cytoplasm
messages: Glycosylated; contains mannose.
messages: Monomer.
messages: Present with 4890 molecules/cell in log phase SD medium.
messages: Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis.

559292:YHR208W
gene id: 559292:YHR208W
uniprot id: P38891
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Highly expressed during logarithmic phase of growth. Down-regulated during the stationary phase.
messages: Involved in the biosynthesis of the branched chain amino acids leucine, isoleucine, and valine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as the amino donors. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1.
messages: Mainly expressed on ammonium-glucose exponential cultures (biosynthetic conditions), and repressed in the presence of leucine, isoleucine or valine.
messages: Mitochondrion matrix
messages: Present with 87300 molecules/cell in log phase SD medium.

559292:YOL110W
gene id: 559292:YOL110W
uniprot id: P41912
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERF4 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERF2.
messages: Present with 937 molecules/cell in log phase SD medium.
messages: The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins (PubMed:12193598, PubMed:12379641, PubMed:7532279). Palmitoylates RAS2, which is required for its proper plasma membrane localization (PubMed:12193598, PubMed:12379641, PubMed:7532279).

559292:YJR040W
gene id: 559292:YJR040W
uniprot id: P37020
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Anion/proton exchange transporter involved in iron and copper cation homeostasis. Involved in intracellular iron metabolism during growth on fermentable and non fermentable carbon sources. Required for proper copper-loading and maturation of multicopper oxidase FET3. Important for adjusting intracellular compartment pH to more alkaline pH under iron limitation. May also transport chloride ions through the plasma membrane.
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer (By similarity). Interacts with GET3.
messages: Prevacuolar compartment membrane
messages: Proteolytically processed in the secretory pathway by protease KEX2 within the first extracellular loop. However, both the N- and C-terminal products of the cleavage reaction are required for assembly of a functional channel.
messages: Was originally thought to be a voltage-gated ClC-type chloride channel.

559292:YOR221C
gene id: 559292:YOR221C
uniprot id: Q12283
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FabD family.
messages: Involved in biosynthesis of fatty acids in mitochondria.
messages: Mitochondrion
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YNL326C
gene id: 559292:YNL326C
uniprot id: P42836
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
messages: Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization.
messages: Present with 2133 molecules/cell in log phase SD medium.
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: Vacuole membrane

559292:YBR008C
gene id: 559292:YBR008C
uniprot id: P38124
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: Probable efflux transporter. Confers resistance to the azole derivative fluconazole (FCZ).

559292:YPL235W
gene id: 559292:YPL235W
uniprot id: Q12464
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes. Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates. The INO80 complex is involved in DNA repair by associating to 'Ser-129' phosphorylated H2A histones as a response to DNA damage. During transcription may recruit SPT15/TBP to the TATA-boxes of involved genes. Required for box C/D and box H/ACA snoRNA accumulation and involved in pre-rRNA processing.
messages: Present with 3030 molecules/cell in log phase SD medium.
messages: Probably forms a homohexamer. Interacts with RVB1 and may form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1. Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Belongs also to the R2TP complex composed of at least RVB1, RVB2, TAH1 and PIH1. Interacts with SPT15/TBP.
messages: nucleoplasm

559292:YKL122C
gene id: 559292:YKL122C
uniprot id: P32342
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Fungal signal recognition particle (SRP) complex consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14. At least SRP14, SRP21, SRP68 and SRP72 are proposed to get assembled together with scR1 RNA as a pre-SRP complex in the nucleolus which is exported to the cytoplasm.
messages: Nucleus
messages: Present with 3400 molecules/cell in log phase SD medium.
messages: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting.

559292:YBR274W
gene id: 559292:YBR274W
uniprot id: P38147
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Nucleus
messages: Present with 2530 molecules/cell in log phase SD medium.
messages: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Controls phosphorylation and abundance of PDS1 to prevent anaphase entry. Also helps prevent mitotic exit.

559292:YNR008W
gene id: 559292:YNR008W
uniprot id: P40345
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Catalyzes triacylglycerol (TAG) formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol (DAG), thus forming an sn-1-lysophospholipid (PubMed:10747858, PubMed:10829075, PubMed:32349126). The preferred acyl donors are phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Also capable of using broad acyl donors such as phosphatidic acid (PA), phosphatidylserine (PS), phosphatidylglycerol (PG) and phosphatidylinositol (PI), as well as monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG), and acyl-CoA, and it is more likely to use unsaturated acyl donors. As acyl acceptors, it prefers 1,2- over 1,3-diacylglycerol (DAG). Additionally, has esterification activity that can utilize methanol as acyl acceptor to generate fatty acid methyl esters (FAME) (PubMed:30706417). Can also utilize ceramide instead of DAG, acylating the ceramides by attaching a fatty acid to the hydroxy group on the first carbon atom of the long-chain base to produce 1-O-acylceramides (PubMed:22738231). Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains (PubMed:32349126). Relocates from the endoplasmic reticulum to a subdomain of the inner nuclear membrane upon nutrient starvation, where it provides a site of TAG synthesis, which is coupled with nuclear membrane remodeling (PubMed:31422915).
messages: Endoplasmic reticulum membrane
messages: Nucleus inner membrane

559292:YNL123W
gene id: 559292:YNL123W
uniprot id: P53920
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1C family.
messages: Interacts with BIR1.
messages: Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1.
messages: Nucleus
messages: Present with 3150 molecules/cell in log phase SD medium.

559292:YDR257C
gene id: 559292:YDR257C
uniprot id: Q12504
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Present with 4010 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-55'.

559292:YJR098C
gene id: 559292:YJR098C
uniprot id: P47139
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Mitochondrion
messages: Present with 1230 molecules/cell in log phase SD medium.

559292:YLR109W
gene id: 559292:YLR109W
uniprot id: P38013
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Biochemical and mutational analysis assigned Cys-120 as the resolving cysteine (C(R)) (PubMed:9888818). However, crystal structures showed that Cys-120 is deeply buried within the protein and revealed formation of a disulfide bond between the peroxidatic cysteine Cys-62 and the therefore more likely C(R) Cys-31 (PubMed:22474296, Ref.21).
messages: By H(2)O(2).
messages: Conjugated to URM1, a ubiquitin-like protein.
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation.
messages: Present with 16228 molecules/cell in log phase SD medium.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys Prx, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Preferentially eliminates organic peroxides rather than hydrogen peroxide (PubMed:10391912, PubMed:9988687, PubMed:10681558). Relays alkyl hydroperoxides as a signal to the transcription factor CAD1/YAP2 by inducing the formation of intramolecular disulfide bonds in CAD1, which causes its nuclear accumulation and activation (PubMed:20145245). Involved in cellular Mn(2+) homeostasis (PubMed:10635552).

559292:YPL067C
gene id: 559292:YPL067C
uniprot id: Q02754
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YML086C
gene id: 559292:YML086C
uniprot id: P54783
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Can oxidize L-gulono-1,4-lactone as well as D-arabinono-1,4-lactone and L-galactono-1,4-lactone.
messages: Mitochondrion membrane
messages: Monomer.
messages: Present with 6190 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YGR030C
gene id: 559292:YGR030C
uniprot id: P53218
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
messages: Nucleus
messages: Present with 3180 molecules/cell in log phase SD medium.

559292:YMR241W
gene id: 559292:YMR241W
uniprot id: Q04013
names: Activity Regulation
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial antiporter which catalyzes the transport of citrate and oxoglutarate across the membrane. Also shows specificity for oxaloacetate, and to a lesser extent succinate and fumarate. Transports isocitrate, cis-aconitate and L-malate with very low efficiency. Does not show uniporter activity. Helps to maintain normal citrate levels and NADPH/NADP(+) ratios under conditions of oxidative stress. In addition, associates with the mitochondrial nucleoid and binds DNA in vitro, although the relevance of these data in vivo is unclear.
messages: Mitochondrion inner membrane
messages: Present with 2930 molecules/cell in log phase SD medium.
messages: Shows slow growth and respiration defects in minimal medium. Shows growth defects in acetate-supplemented medium; the phenotype is enhanced by addition of hydrogen peroxide (increased oxidative stress) and/or double knockout of YHM2 and ZWF1. The cytosolic NADPH/NADP(+) ratio is decreased compared to wild type; this effect is enhanced in the presence of hydrogen peroxide. The mitochondrial NADPH/NADP(+) ratio is increased, but only in the presence of hydrogen peroxide. Levels of cytosolic citrate are reduced, but only in the presence of hydrogen peroxide. Levels of cytosolic oxoglutarate are reduced, but only in the presence of hydrogen peroxide; the effect is enhanced by double knockout of YHM2 and ZWF1. Cells show a very small increase in levels of reactive oxygen species (ROS) following hydrogen peroxide treatment; in double knockouts of YHM2 and ZWF1 there is a large increase in ROS. Overexpression suppresses the temperature-sensitive growth defect of ABF2 in glucose-rich medium.
messages: Strongly inhibited by mersalyl, p-chloromercuribenzenesulfonate, mercuric chloride, N-ethylmaleimide, pyridoxal 5'-phosphate, bathophenanthroline, and tannic acid. Partially inhibited by alpha-cyanocinnamate and bromescol purple. Weakly inhibited by butylmalonate and phenylsuccinate. Not inhibited by 1,2,3-benzenetricarboxylate or carboxyatractyloside.
messages: Was originally proposed to function in mitochondrial DNA replication and maintenance.
messages: mitochondrion nucleoid

559292:YPR041W
gene id: 559292:YPR041W
uniprot id: P38431
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). eIF-5 is essential for cell viability.
messages: Monomer. Interacts with NIP1 and SUI3. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. TIF32, NIP1 and TIF5/eIF-5 comprise a minimal 40S-ribosome-binding unit.
messages: Present with 48300 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-18 of isoform Long.

559292:YBR011C
gene id: 559292:YBR011C
uniprot id: P00817
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Cytoplasm
messages: Homodimer.
messages: Present with 68400 molecules/cell in log phase SD medium.

559292:YGL121C
gene id: 559292:YGL121C
uniprot id: P53130
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: By heat.
messages: Cytoplasm
messages: G proteins are composed of 3 units, alpha, beta and gamma. GPG1 interacts with the beta subunits GBP1 and GPB2.
messages: Gamma subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth.

559292:YHR019C
gene id: 559292:YHR019C
uniprot id: P38707
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn).
messages: cytosol

559292:YOR260W
gene id: 559292:YOR260W
uniprot id: P09032
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as essential component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD1 stabilizes the interaction between eIF-2 and GCD6 and stimulates the catalytic activity in vitro.
messages: Belongs to the eIF-2B gamma/epsilon subunits family.
messages: Present with 9530 molecules/cell in log phase SD medium.
messages: Translation initiation factor 2B (eIF2-B) is composed of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6). A catalytic subcomplex comprising GCD1 and GCD6 interacts with both, phosphorylated and non-phosphorylated eIF-2 and has exchange activity in vitro.

559292:YOR168W
gene id: 559292:YOR168W
uniprot id: P13188
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Present with 37500 molecules/cell in log phase SD medium.

559292:YDR326C
gene id: 559292:YDR326C
uniprot id: Q06681
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Endoplasmic reticulum membrane
messages: Involved in induction of programmed cell death in response to reactive oxygen species (ROS) (PubMed:16962064). May be involved in sterol transfer between intracellular membranes (PubMed:26001273).
messages: Mitochondrion membrane
messages: The VASt domains bind sterols.

559292:YOR357C
gene id: 559292:YOR357C
uniprot id: Q08826
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Monomer. Interacts with RBD2, YIF1, YIP1 and YIP5.
messages: Prevacuolar compartment membrane
messages: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).

559292:YIL083C
gene id: 559292:YIL083C
uniprot id: P40506
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPC synthetase family.
messages: Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 3170 molecules/cell in log phase SD medium.

559292:YMR033W
gene id: 559292:YMR033W
uniprot id: Q05123
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family.
messages: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in transcriptional regulation. Heterodimer of ARP9 and ARP7 functions with HMG box proteins to facilitate proper chromatin architecture. Heterodimer formation is necessary for assembly into RSC complex. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Forms a heterodimer with ARP7. Interacts with LDB7 and NPL6. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Nucleus
messages: Present with 1790 molecules/cell in log phase SD medium.

559292:YEL003W
gene id: 559292:YEL003W
uniprot id: P40005
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Cytoplasm
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Present with 1660 molecules/cell in log phase SD medium.

559292:YNL138W-A
gene id: 559292:YNL138W-A
uniprot id: P0C074
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3b complex composed of CUS1, HSH49, HSH155, RCP1, RDS3 and RSE1.
messages: Involved in pre-mRNA splicing. Required for the SF3b integrity and prespliceosome assembly.
messages: Nucleus

559292:YDL192W
gene id: 559292:YDL192W
uniprot id: P11076
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in Golgi vesicle trafficking (PubMed:15356266, PubMed:34830155). May modulate vesicle budding and uncoating within the Golgi apparatus (PubMed:15356266). May recruit the lipid transfer protein VPS13 to Golgi membranes (PubMed:34830155). Recruits polyadenylate-binding protein PAB1 to COPI vesicles, and this is required for correct localization of the asymmetrically distributed ASH1 mRNA (PubMed:15356266).
messages: Golgi apparatus
messages: Interacts with RUD3 (PubMed:15356266, PubMed:15504911, PubMed:19141284, PubMed:20601958). Interacts with VPS13 (via C-terminal part); the interaction is direct (PubMed:34830155).
messages: Present with 19300 molecules/cell in log phase SD medium.

559292:YIL119C
gene id: 559292:YIL119C
uniprot id: P23250
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Negative regulator of the Ras-cyclic AMP pathway. Negatively regulate the activity of normal but not mutationally activated Ras proteins. The down-regulatory effect of RPI1 requires the presence of one of the two Ras GTPase activators, IRA1 and IRA2.
messages: Nucleus
messages: Present with 1340 molecules/cell in log phase SD medium.

559292:YEL024W
gene id: 559292:YEL024W
uniprot id: P08067
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:1657998, PubMed:2538628, PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). RIP1 interacts with QCR10 on the intermembrane space (IMS) side, and with QCR9 (PubMed:30598556, PubMed:30598554).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster (PubMed:18390544). It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b (COB) to cytochrome c1 (CYT1) (PubMed:1657998, PubMed:2538628) (Probable).
messages: Mitochondrion inner membrane
messages: Processed by both the mitochondrial processing peptidase (MPP) and the mitochondrial intermediate protease (MIP). Initially, MPP removes 22 amino acids from the newly imported precursor in the mitochondrial matrix. This proteolytic processing is then followed by a second proteolytic cleavage by MIP, which removes an octapeptide to generate mature-sized RIP1.
messages: The Rieske protein is a high potential 2Fe-2S protein.

559292:YDR336W
gene id: 559292:YDR336W
uniprot id: Q05473
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion
messages: Sumoylated upon ethanol stress.

559292:YJR070C
gene id: 559292:YJR070C
uniprot id: P47120
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
messages: Cytoplasm
messages: Nucleus
messages: Present with 39900 molecules/cell in log phase SD medium.

559292:YIL084C
gene id: 559292:YIL084C
uniprot id: P40505
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDS3 family.
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association.
messages: Nucleus
messages: Present with 105 molecules/cell in log phase SD medium.

559292:YER004W
gene id: 559292:YER004W
uniprot id: P40008
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP52 family.
messages: Mitochondrion outer membrane
messages: Present with 1340 molecules/cell in log phase SD medium.

559292:YIR003W
gene id: 559292:YIR003W
uniprot id: P40563
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AIM21 family.
messages: Increases the sensitivity to farnesol.
messages: Interacts with ribosomes. Interacts with ABP1.
messages: Involved in mitochondrial migration along actin filaments.
messages: Present with 450 molecules/cell in log phase SD medium.
messages: actin patch

559292:YFL025C
gene id: 559292:YFL025C
uniprot id: P43571
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Glycosylated.
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. Required for the transport of misfolded protein to the Golgi, although dipensable for the transport of many normal proteins.

559292:YOR106W
gene id: 559292:YOR106W
uniprot id: Q12241
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with VAM7.
messages: Belongs to the syntaxin family.
messages: Present with 414 molecules/cell in log phase SD medium.
messages: Required for vacuolar assembly. Provides the t-SNARE function in a late step of the vacuolar assembly. Required for homotypic vacuole membrane fusion, autophagy and fusion of biosynthetic transport vesicles with the vacuole. Required for the delivery of alpha-factor receptor-ligand complexes to the vacuole.
messages: Vacuole membrane

559292:YNL209W
gene id: 559292:YNL209W
uniprot id: P40150
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.
messages: Binds to ribosomes (PubMed:9670014, PubMed:1394434, PubMed:27917864). Binds close to the ribosomal tunnel exit via contacts with both ribosomal proteins RPL35, RPL39 and RPL19, and rRNA (By similarity). Directly interacts with nascent polypeptides. This interaction is dependent on the ribosome-associated complex (RAC) (PubMed:11929994, PubMed:23332755). Interacts with SSE1 (PubMed:23332755).
messages: Cytoplasm
messages: Expression decreases after heat shock or during growth to stationary phase (PubMed:6761581, PubMed:2651414). Up-regulated upon carbon upshift and down-regulated upon amino acid limitation in an HSF1-dependent manner (PubMed:10322015). Interacts with SSE1 (PubMed:16219770, PubMed:16221677). Interacts with FES1 (By similarity).
messages: Present with 104000 molecules/cell in log phase SD medium.
messages: Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone SSE1 and FES1 act as nucleotide exchange factors that cause substrate release.

559292:YLR022C
gene id: 559292:YLR022C
uniprot id: Q07953
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 60S ribosomal subunit.
messages: Belongs to the SDO1/SBDS family.
messages: Cytoplasm
messages: Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with the EF-2-like GTPase RIA1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.
messages: Nucleus
messages: Present with 5060 molecules/cell in log phase SD medium.

559292:YPL133C
gene id: 559292:YPL133C
uniprot id: P19541
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by SNF1 in absence of glucose. The phosphorylation is required for induction of transcription of gluconeogenic genes.
messages: Present with 799 molecules/cell in log phase SD medium.
messages: Sensitivity to ketoconazole.
messages: Transcription factor which regulates the expression of genes for gluconeogenesis, the TCA cycle, and glucose metabolism. Involved in the cell wall remodeling process and drug resistance.

559292:YNR067C
gene id: 559292:YNR067C
uniprot id: P53753
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 81 family.
messages: Cleaves internal linkages in 1,3-beta-glucan (PubMed:12455695). Involved in the dissolution of the mother-daughter septum during cell separation (PubMed:12455695).
messages: Glycosylated.
messages: Present with 64 molecules/cell in log phase SD medium.
messages: cell wall

559292:YHR103W
gene id: 559292:YHR103W
uniprot id: P38814
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SBE2 family.
messages: Cytoplasm
messages: Golgi apparatus
messages: With SBE2, is involved in cell wall integrity and polarity processes like bud growth, through the transport of CHS3 and UTR2 to sites of growth.

559292:YPL263C
gene id: 559292:YPL263C
uniprot id: Q08979
names: Miscellaneous
messages: Present with 4010 molecules/cell in log phase SD medium.

559292:YIL052C
gene id: 559292:YIL052C
uniprot id: P40525
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL34 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 21000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL34 in yeast.

559292:YER118C
gene id: 559292:YER118C
uniprot id: P40073
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHO1 family.
messages: Bud
messages: Bud neck
messages: Cell membrane
messages: Cell projection
messages: Forms homooligomers. Interacts (via the SH3 domain) with PBS2. Interacts with FUS1, STE11, STE50 and RNA polymerase II.
messages: Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane. PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures. Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress. Involved in the regulation of the mating pathway. May be a receptor that feeds into the pseudohyphal growth pathway.
messages: Present with 2330 molecules/cell in log phase SD medium.

559292:YBL052C
gene id: 559292:YBL052C
uniprot id: P34218
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation at Lys-367 is required for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Catalytic component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. In vitro, SAS3 acetylates free histones H3 and H4. It is involved in silencing the HMR locus.
messages: Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6. SAS3 interacts with CDC68/SPT16.
messages: Nucleus

559292:YJL028W
gene id: 559292:YJL028W
uniprot id: P47062
names: Subcellular Location Annotation
messages: Membrane

559292:YLR019W
gene id: 559292:YLR019W
uniprot id: Q07949
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Probable phosphatase. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR1. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.

559292:YNR052C
gene id: 559292:YNR052C
uniprot id: P39008
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as probably catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. In vitro, POP2 has 3'-exoribonuclease activity with a preference for poly(A) RNAs, but also degrades poly(U) and poly(C) RNAs. Is part of a glucose-sensing system involved in growth control in response to glucose availability.
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Divalent metal cations. Mg(2+) is the most probable.
messages: Nucleus
messages: Present with 1520 molecules/cell in log phase SD medium.
messages: Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.

559292:YOR077W
gene id: 559292:YOR077W
uniprot id: P40962
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 4590 molecules/cell in log phase SD medium.

559292:YJR143C
gene id: 559292:YJR143C
uniprot id: P46971
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Forms a functional homodimer and may form a heterodimer with PMT6. Interacts with RCR1.
messages: Leads to diminished MID2 O-mannosylation.
messages: Present with 1270 molecules/cell in log phase SD medium.
messages: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a homodimeric complex to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. Specifically acts on secretory proteins with an ER-luminally oriented Ser/Thr-rich region flanked by a membrane anchor such as FUS1, AXL2, GAS1, KEX2, MID2, WSC1, WSC2, OPY2, PRM5, RAX2, or YNL176.

559292:YBR012W-A
gene id: 559292:YBR012W-A
uniprot id: Q12217
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-BR is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YKL065W-A
gene id: 559292:YKL065W-A
uniprot id: Q2V2P2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Membrane

559292:YPR030W
gene id: 559292:YPR030W
uniprot id: Q12734
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSR2 family.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by CDC28.
messages: Repressed by glucose and increased expression upon nitrogen depletion.
messages: Transcription factor involved in the regulation of fermentation and aerobic oxidation. Acts as a repressor of CYC1, which is involved in electron flow through the mitochondria under aerobic condition. Required for pseudohyphal formation upon nitrogen starvation. May be involved in viability at stationary phase and aging.

559292:YBL006C
gene id: 559292:YBL006C
uniprot id: P38210
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Together with HTL1, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. May be involved in the transfer of mannosylphosphate (MP) groups into N-linked oligosaccharides.
messages: Interacts with STH1, RSC3 and ARP9. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Component of a fungal-specific module (HTL1-LDB7-NPL6-RSC3-RSC30) within the RSC complex.
messages: Nucleus

559292:YLR044C
gene id: 559292:YLR044C
uniprot id: P06169
names: Activity Regulation
names: Biotechnology
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by its substrate, pyruvate.
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cleavage of N-terminal methionine and N-terminal acetylation by NAT1/ARD1.
messages: Cytoplasm
messages: Fusel oils and acyloins are important flavor and aroma compounds in yeast-fermented products contributing to the quality of beverages and food, e.g. fusel oils in whiskey, contrary to common believe, seem to alleviate hangover. In general they are desirable at low concentrations, whereas high concentrations may spoil the product. By adjusting growth conditions and substrate their production is sought to be influenced. Due to their broad substrate tolerance pyruvate decarboxylases are important biocatalysts for chemoenzymatic syntheses, both by fermentation and in vitro, e.g. in the production of ephedrine, vitamin E, or phenylethanol (rose flavor).
messages: Homotetramer.
messages: Major of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-ketoacids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids derived from threonine (2-oxobutanoate), norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, also alpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate), and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins.
messages: Nucleus
messages: Present with 8966 molecules/cell in log phase SD medium.
messages: Protein expression is strongly induced by high concentrations of fermentable carbon sources and under anaerobic growth conditions and is repressed by ethanol. Protein expression level is also autoregulated through an unknown mechanism.

559292:YGR286C
gene id: 559292:YGR286C
uniprot id: P32451
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YDL049C
gene id: 559292:YDL049C
uniprot id: P50112
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: O-glycosylated.
messages: cell wall

559292:YCL014W
gene id: 559292:YCL014W
uniprot id: P25558
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BUD3 family.
messages: Co-assembles with BUD4 at bud sites. BUD4 and BUD3 may cooperate to recognize a spatial landmark (the neck filaments) during mitosis and they subsequently become a landmark for establishing the axial budding pattern in G1.
messages: Interacts with AXL2.

559292:YPL082C
gene id: 559292:YPL082C
uniprot id: P32333
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Forms a complex with TBP which binds TATA DNA with high affinity but with altered specificity.
messages: Mitochondrion
messages: Nucleus
messages: Present with 6560 molecules/cell in log phase SD medium.
messages: Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity.

559292:YIL017C
gene id: 559292:YIL017C
uniprot id: P40547
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in the GID complex. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is induced and becomes part of the complex (PubMed:22645139). Within the GID complex, interacts directly with RMD5/GID2 and FYV10/GID9, and recruits VID24/GID4 to the complex when cells are shifted to glucose-containing medium (PubMed:22645139).
messages: Nucleus
messages: Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616).

559292:YML021C
gene id: 559292:YML021C
uniprot id: P12887
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Not involved in strand-directed mismatch repair.
messages: Induced in late G1 and early S phase of the cell cycle.
messages: Mitochondrion
messages: Nucleus
messages: Present with 4820 molecules/cell in log phase SD medium.

559292:YKR006C
gene id: 559292:YKR006C
uniprot id: Q02204
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 1350 molecules/cell in log phase SD medium.

559292:YBR088C
gene id: 559292:YBR088C
uniprot id: P15873
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer (PubMed:15201901). Interacts with RAD30 (PubMed:11545742). Interacts with MCM10 (PubMed:16782870). Interacts with UBP10 (PubMed:22829782).
messages: Lys-164 is deubiquitinated by UBP10 (PubMed:22829782).
messages: Monoubiquitinated on Lys-164 by the UBC2/RAD18 complex upon DNA damage, and then polyubiquitinated through 'Lys-63'-linkage by UBC13/MMS2. Ubiquitination is required for UBC2-mediated DNA repair.
messages: Nucleus
messages: Sumoylated on Lys-164, and to a lesser extent on Lys-127 by the UBC9/SIZ1 complex during S-phase; which impairs ubiquitination and function in DNA repair.
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.

559292:YGL259W
gene id: 559292:YGL259W
uniprot id: P53057
names: Caution
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Could be the product of a pseudogene. Contains only the N-ter part of the functional aspartic proteinases.

559292:Q0255
gene id: 559292:Q0255
uniprot id: P03881
names: Subcellular Location Annotation
messages: Mitochondrion

559292:YJL037W
gene id: 559292:YJL037W
uniprot id: P47056
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSW4/6 family.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells (PubMed:18085829). A combined deletion of the LOH1/OSW4 and IRC18/OSW6 has reduced dityrosine incorporation in the outer spore wall (PubMed:23966878).
messages: In respiratory-deficient cells and by heat.
messages: Involved in spore wall assembly.
messages: Membrane

559292:YLR228C
gene id: 559292:YLR228C
uniprot id: Q05958
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: ECM22 and UPC2 (in combination) null mutants are not viable.
messages: Nucleus
messages: Present with 79 molecules/cell in log phase SD medium.
messages: Transcription factor involved in sterol uptake and regulation of sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters and regulates transcription of ERG2 and ERG3 in response to sterol levels. Seems to be involved in activation of DAN2 and DAN3 cell wall mannoproteins.

559292:YKR050W
gene id: 559292:YKR050W
uniprot id: P28584
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane
messages: This protein is required for low-affinity potassium transport.

559292:YJR030C
gene id: 559292:YJR030C
uniprot id: P47101
names: Caution
names: Sequence Caution
names: Similarity
messages: Belongs to the UPF0508 family.
messages: Contains PCR fragment of strain VP102-10A.
messages: This is a truncated version of an UPF0508 family protein. Strain S288c has a tandem insertion of a Ty1 transposon in position 742, which disrupts the gene coding for this protein and produces two ORFs YJR030C and YJR025C-A. A contiguous sequence of this protein can be found in strain YJM789 (AC A6ZPZ1).

559292:YLR193C
gene id: 559292:YLR193C
uniprot id: Q05776
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the slowmo family.
messages: Cells show slow growth, fragmented mitochondria and have a 50-fold reduced level of s-MGM1. These defects can be complemented by human PRELI or bypassed by growth on a nonfermentable carbon source.
messages: Interacts with MDM35 (PubMed:20622808, PubMed:20657548, PubMed:26071602, PubMed:26071601, PubMed:26235513). Found associated with a 170 kDa complex.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Present with 704 molecules/cell in log phase SD medium.
messages: Required for maintenance of normal mitochondrial morphology (PubMed:16754953, PubMed:26071601). Required for PCP1-dependent processing of MGM1 (PubMed:16754953). The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071602, PubMed:26071601, PubMed:26235513). Phosphatidic acid release requires dissociation of the UPS1:MDM35 complex (PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602). With UPS2, controls the level of cardiolipin in mitochondria (PubMed:19506038). Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.

559292:YDL042C
gene id: 559292:YDL042C
uniprot id: P06700
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Homomultimer. Forms a complex with SIR3 and SIR4 (PubMed:9122169). Component of the RENT complex, at least composed of SIR2, CDC14 and NET1 (PubMed:10219244, PubMed:10219245). The RENT complex interacts with FOB1 (PubMed:12923057). Interacts with ESC8 (PubMed:12399377). Interacts with and ZDS2 (PubMed:10662670). Interacts with MCM10 (PubMed:16328881). Interacts with SLX5 (PubMed:18086879). Interacts with NSI1 (PubMed:22362748).
messages: Its activity is increased by calorie restriction, which slows the pace of aging and increases maximum lifespan. Activated by resveratrol (3,5,4'-trihydroxy-trans-stilbene), which is found in red wine.
messages: Its stability is directly linked to life span, which is extended when it is present in high dosage. Conversely, its absence shortens life span.
messages: NAD-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, DNA recombination and the determination of life span. Involved in transcriptional repression of the silent mating-type loci HML and HMR and telomeric silencing via its association with SIR3 and SIR4. Plays a central role in ribosomal DNA (rDNA) silencing via its association with the RENT complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. Probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. Although it displays some NAD-dependent histone deacetylase activity on histone H3K9Ac and H3K14Ac and histone H4K16Ac in vitro, such activity is unclear in vivo and may not be essential.
messages: Present with 3350 molecules/cell in log phase SD medium.
messages: The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Was originally thought to be an ADP-ribosyltransferase.
messages: nucleolus

559292:YKL049C
gene id: 559292:YKL049C
uniprot id: P36012
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core (PubMed:32004465, PubMed:14581449). The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers (PubMed:32004465, PubMed:14581449). Interacts with the inner kinetochore (PubMed:14581449). Interacts with the central kinetochore protein CTF19 (PubMed:10958698). Interacts with YTA7 (PubMed:32079723).
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for functional chromatin architecture at the yeast 2-micron circle partitioning locus and promotes equal plasmid segregation.
messages: Mutation in CSE4 causes chromosome non-disjunction and cell cycle arrest at mitosis.
messages: Nucleus
messages: Ubiquitinated (Probable). Is degraded through ubiquitin-mediated proteolysis when not protected by its association to the kinetochore (Probable).
messages: centromere

559292:YBR026C
gene id: 559292:YBR026C
uniprot id: P38071
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.
messages: Homodimer or in a complex with other proteins (PubMed:11509667). Interacts with ARS1 (PubMed:8195160).
messages: Mitochondrion matrix
messages: Positively regulated by the zinc-responsive transcriptional regulator ZAP1.
messages: Present with 1560 molecules/cell in log phase SD medium.
messages: Was originally (PubMed:8195160) thought to be a nuclear protein involved in transcriptional regulation of genes required for the functional assembly of mitochondrial respiratory proteins. This was later proven not to be the case (PubMed:11509667).

559292:YLR090W
gene id: 559292:YLR090W
uniprot id: P39102
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane
messages: Present with 1210 molecules/cell in log phase SD medium.

559292:YOR316C
gene id: 559292:YOR316C
uniprot id: P32798
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: COT1 has a paralog, ZRC1, that arose from the whole genome duplication.
messages: Contains 3 histidine repeat motifs between the 4th and 5th transmembrane, exposed to the cytoplasm, that may be involved in the binding site of zinc.
messages: Expression is increased in response to DNA replication stress.
messages: Present with 2070 molecules/cell in log phase SD medium.
messages: Reduces zinc transport into the vacuole and hence limit the over-accumulation of zinc caused by the deletion of ZRT3.
messages: Vacuolar transporter that regulates zinc homeostasis by mediating zinc transport and storage into the vacuole (PubMed:9712830, PubMed:10856230, PubMed:12556516). Plays a role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm (PubMed:12556516). May also participate in the regulation of cobalt levels under normal physiological conditions and may be important in the supply of metal that is required for metalloenzyme or cofactor synthesis (PubMed:1508175, PubMed:18930916). Involved in the resistance to cobalt and rhodium ions (PubMed:1508175).
messages: Vacuole membrane

559292:YKL124W
gene id: 559292:YKL124W
uniprot id: P32343
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSH4 family.
messages: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane. Confers leflunomide resistance when overexpressed.
messages: Endosome membrane
messages: Present with 450 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YHR173C
gene id: 559292:YHR173C
uniprot id: P38864
names: Miscellaneous
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YOL049W
gene id: 559292:YOL049W
uniprot id: Q08220
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Present with 3430 molecules/cell in log phase SD medium.

559292:YBR193C
gene id: 559292:YBR193C
uniprot id: P38304
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. MED8 binds to the consensus sequence 5'-[AC][AG]GAAAT-3' in both the UAS of SUC2 and the DRS2 of HXK2.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. MED8 interacts directly with SRB5/MED18. Interacts also with Hexokinase B (HXK2). Interacts with TBP1.
messages: Nucleus
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YGL198W
gene id: 559292:YGL198W
uniprot id: P53093
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Interacts with TVP18, TVP23, YIP1 and YIP5. Interacts with SEC4, YPT1, YPT6, YPT7, YPT10, YPT11, YPT31, YPT32 and YPT52; These proteins are all Rab GTPases.
messages: May be involved in proper membrane localization of Rab GTPases.

559292:YDL009C
gene id: 559292:YDL009C
uniprot id: Q12210
names: Subcellular Location Annotation
messages: Membrane

559292:YNR007C
gene id: 559292:YNR007C
uniprot id: P40344
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATG12-ATG5 induces reorientation of the ATG3 structure, increasing conjugation activity of ATG3.
messages: Acetylated by NuA4 complex acetyltransferase ESA1 at Lys-19 and Lys-48. Acetylation regulates autophagy by controlling ATG8 interaction and lipidation. Deacetylated by histone deacetylase RPD3.
messages: Belongs to the ATG3 family.
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
messages: Expression is increased during filamentous growth and controlled by the RSF2 transcription factor.
messages: Mitochondrion
messages: Monomer. Interacts with ATG8 through an intermediate thioester bond between Cys-234 and the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Interacts also with the ATG12-ATG5 conjugate.
messages: Present with 3610 molecules/cell in log phase SD medium.
messages: The N-terminal region (residues 1-7) is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation.
messages: The flexible region (FR) is required for ATG7-binding.
messages: The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway.

559292:YDL129W
gene id: 559292:YDL129W
uniprot id: Q07555
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YIL116W
gene id: 559292:YIL116W
uniprot id: P07172
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

559292:YOR018W
gene id: 559292:YOR018W
uniprot id: Q02805
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Interacts with RSP5 via its 2 PY-motifs.
messages: Mediates resistance to o-dinitrobenzene, calcium and zinc.
messages: Membrane
messages: Present with 386 molecules/cell in log phase SD medium.
messages: The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase and important for resistance to o-dinitrobenzene.

559292:YBR185C
gene id: 559292:YBR185C
uniprot id: P38300
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with OXA1 and MDM38. Binds to mitoribosomes in order to recruit them to the mitochondrial inner membrane.
messages: Leads to a reduced growth rate on non-fermentable carbon sources, which is more pronounced at high temperature (PubMed:8690083, PubMed:18727146). Shows defects in the membrane insertion of nascent chains resulting in the accumulation of the precursor form of subunit 2 of cytochrome oxidase (PubMed:20427570, PubMed:25609543).
messages: Mitochondrial inner membrane-associated mitoribosome receptor that spatially aligns the mitoribosome exit tunnel with the membrane insertion machinery and allows cotranslational protein membrane insertion.
messages: Mitochondrion inner membrane
messages: Present with 2720 molecules/cell in log phase SD medium.

559292:YLR048W
gene id: 559292:YLR048W
uniprot id: P46654
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS2 is required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (PubMed:9973221, PubMed:14627813).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 60900 molecules/cell in log phase SD medium.
messages: Reduction in growth rate, a decrease in free 40S subunits, an increase in the amount of free 60S subunits and a decrease in polysome size.
messages: There are 2 genes for uS2 in yeast.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. This protein does not bind laminin.

559292:YDL161W
gene id: 559292:YDL161W
uniprot id: Q12518
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the epsin family.
messages: Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. Negatively regulated via phosphorylation.
messages: Cytoplasm
messages: Interacts with EDE1 and PAN1.
messages: Membrane

559292:YLR373C
gene id: 559292:YLR373C
uniprot id: Q05934
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VID22 family.
messages: Cell membrane
messages: Glycosylated.
messages: Has a role in the negative regulation of gluconeogenesis. Imports fructose-1,6-bisphosphatase (FBPase) into the intermediate vacuole import and degradation (Vid) vesicles. This is an indirect role and requires cyclophilin A.
messages: Nucleus
messages: Present with 2950 molecules/cell in log phase SD medium.

559292:YGR223C
gene id: 559292:YGR223C
uniprot id: P50079
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Contains a beta-propeller domain involved in specific binding of phosphatidylinositol 3,5-bisphosphate.
messages: Endosome membrane
messages: Involved in piecemeal microautophagy of the nucleus (micronucleophagy).
messages: N-glycosylated.
messages: Prevacuolar compartment membrane

559292:YBR085W
gene id: 559292:YBR085W
uniprot id: P18238
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:2165073). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Present with 1080 molecules/cell in log phase SD medium.
messages: The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR).
messages: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

559292:YPL001W
gene id: 559292:YPL001W
uniprot id: Q12341
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of free histone H4 in the cytoplasm. The complex is also found in the nucleus, however it is not certain that it modifies histone H4 when packaged in chromatin. Histone H4 'Lys-12' acetylation is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. In the cytoplasm, this complex binds to the histone H4 tail. In the nucleus, the HAT-B complex has an additional component, the histone H3/H4 chaperone HIF1.
messages: Cytoplasm
messages: Nucleus

559292:YJL216C
gene id: 559292:YJL216C
uniprot id: P40884
names: Function
names: Induction
names: Similarity
messages: Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose.
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Transcriptionally regulated by PDR8. Expression is increased in response to the addition of maltose, isomaltose, and alpha-methylglucopyranoside.

559292:YBL078C
gene id: 559292:YBL078C
uniprot id: P38182
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG8 family.
messages: Conjugation to phosphatidylethanolamine (PE) leads to homodimerization. Interacts with ATG1, ATG3, ATG4, ATG7, ATG12, ATG32, ATG34 and the C-terminal 10 residues domain of ATG19. Interacts also with the endoplasmic reticulum to Golgi v-SNARE protein BET1 and the vacuolar v-SNARE protein NYV1. Interacts with the UBX domain-containing protein SHP1.
messages: Mitochondrion membrane
messages: Present with 2010 molecules/cell in log phase SD medium.
messages: The C-terminal Arg-117 residue of ATG8 is removed by ATG4 to expose Gly-116 at the C-terminus (PubMed:11038174, PubMed:11149920, PubMed:16680092). This Gly-116 forms then a thioester bond with the 'Cys-507' of ATG7 (E1-like activating enzyme) before being transferred to the 'Cys-234' of ATG3 (the specific E2 conjugating enzyme), in order to be finally amidated with phosphatidylethanolamine (PubMed:11100732, PubMed:15277523, PubMed:20615880, PubMed:17632063, PubMed:17699586, PubMed:18725539, PubMed:19285500, PubMed:23064152, PubMed:22539722, PubMed:28330855, PubMed:20428927). This lipid modification anchors ATG8 to membranes and can be reversed by ATG4, releasing soluble ATG8 (PubMed:22240591, PubMed:22622160, PubMed:22652539, PubMed:28330855).
messages: Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. Moreover not only conjugation, but also subsequent ATG8-PE deconjugation is an important step required to facilitate multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. Also plays a role in regulation of filamentous growth.
messages: Up-regulated upon starvation conditions. Expression is under the control of UME6 which acts along with a histone deacetylase complex including SIN3 and RPD3 to regulate negatively ATG8 levels and subsequent autophagic activity.
messages: Vacuole membrane
messages: autophagosome membrane
messages: cvt vesicle membrane

559292:YJL123C
gene id: 559292:YJL123C
uniprot id: P47018
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MTC1 family.
messages: COPI-coated vesicle
messages: Cytoplasm
messages: Interacts with ribosomes.
messages: Involved in telomere capping.
messages: Present with 2160 molecules/cell in log phase SD medium.

559292:YHR080C
gene id: 559292:YHR080C
uniprot id: P38800
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in sterol transfer between intracellular membranes.
messages: The VASt domains bind sterols.

559292:YJL097W
gene id: 559292:YJL097W
uniprot id: P40857
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Vacuole membrane

559292:YDR311W
gene id: 559292:YDR311W
uniprot id: P32776
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB1 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription (PubMed:7961739, PubMed:7813015, PubMed:14500720). Interacts with XPC/RAD4. XPC/RAD4 recruits TFIIH to the NER machinery (PubMed:23295669). Interacts with the NER 3'-endonuclease XPG/RAD2. XPG/RAD2 displaces XPC/RAD4 from the repair complex (PubMed:22373916, PubMed:23295669).
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus
messages: Present with 5150 molecules/cell in log phase SD medium.

559292:YIL133C
gene id: 559292:YIL133C
uniprot id: P26784
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 43300 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL13 in yeast.

559292:YCL024W
gene id: 559292:YCL024W
uniprot id: P25389
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Bud neck
messages: Interacts with septin proteins, primarily with CDC11. Interacts with SWE1 and NAP1.
messages: Involved in regulation of bud growth during cell cycle and in septin organization. Plays a role in cell wall synthesis.
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YGL131C
gene id: 559292:YGL131C
uniprot id: P53127
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the Snt2C complex composed of SNT2, ECM5 and RPD3. Interacts with the E2 ubiquitin-conjugating enzyme UBC4 and histones H3 and H4. Binding is enhanced to methylated histone H3K36me3.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional regulator that, together with ECM5, recruits histone deacetylase RPD3 to a small number of promoters of stress-response genes in response to oxidative stress (PubMed:23878396). Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation (PubMed:22570702).

559292:YKR070W
gene id: 559292:YKR070W
uniprot id: P36151
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Present with 3870 molecules/cell in log phase SD medium.

559292:YER160C
gene id: 559292:YER160C
uniprot id: Q03619
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YER159C-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YBR210W
gene id: 559292:YBR210W
uniprot id: P38312
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

559292:YHR068W
gene id: 559292:YHR068W
uniprot id: P38791
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
messages: Homotetramer.
messages: Present with 7600 molecules/cell in log phase SD medium.

559292:YNR009W
gene id: 559292:YNR009W
uniprot id: P53718
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: During G1 phase of the cell cycle.
messages: Negative regulatory component of the MBF complex involved in cell-cycle-dependent transcription.
messages: Nucleus
messages: Present with 2880 molecules/cell in log phase SD medium.
messages: The MBF complex is composed of at least SWI6, MBP1 and NRM1.

559292:YOR191W
gene id: 559292:YOR191W
uniprot id: Q08562
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Interacts with CDC3, CDC11, EBP2, SIR4, UBC4 and SUMO/SMT3.
messages: Nucleus

559292:YML041C
gene id: 559292:YML041C
uniprot id: Q03433
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWR1 complex at least composed of ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWR1 and HTZ1.
messages: Nucleus
messages: Participates in the catalytic exchange of histone H2A for the H2A variant HZT1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes. Indirectly involved in vacuolar protein sorting.

559292:YOR329C
gene id: 559292:YOR329C
uniprot id: P34758
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts (via KKVRF motif) with phosphatase GLC7.
messages: Membrane
messages: Phosphorylation by PRK1 and/or AKL1 on Thr-416, Thr-450 and Thr-490 of repeats 1-1, 1-2 and/or 1-3 negatively regulates SCD5 function in endocytosis and actin cytoskeleton organization.
messages: Present with 704 molecules/cell in log phase SD medium.
messages: Regulates both fluid phase and receptor-mediated endocytosis (PubMed:12356757, PubMed:12956961). Involved in vesicular transport at a late stage of the secretory pathway (PubMed:8688556). Regulates actin cytoskeleton organization (PubMed:12356757, PubMed:12956961).

559292:YNL086W
gene id: 559292:YNL086W
uniprot id: P48232
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPIN family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
messages: Endosome
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YCL033C
gene id: 559292:YCL033C
uniprot id: P25566
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-R-sulfoxide reductase which catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. Protects iron-sulfur clusters from oxidative inactivation along with MXR1. Involved in the regulation of lifespan.
messages: Present with 799 molecules/cell in log phase SD medium.

559292:YDR302W
gene id: 559292:YDR302W
uniprot id: Q06636
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein. Required for the formation of complete GPI precursors CP1 and CP2.
messages: Belongs to the PIGF family.
messages: Endoplasmic reticulum membrane

559292:YDL154W
gene id: 559292:YDL154W
uniprot id: Q12175
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Heterooligomer of MSH4 and MSH5.
messages: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.
messages: Two distinct classes of crossovers have been demonstrated in budding yeast. Class I is MSH4/MSH5 dependent and exhibits crossover interference. Class II is MUS81/MMS4 dependent and exhibits no interference.

559292:YOR321W
gene id: 559292:YOR321W
uniprot id: P47190
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects O-mannosylation activity only when PTM1 and PTM2 are absent.
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: PMT3 and PMT5 form a functional heterodimer. Forms also a minor complex with PMT1.
messages: Present with 2720 molecules/cell in log phase SD medium.
messages: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT5 and more rarely with PMT1 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. Seems to have redundant activity to PMT2.
messages: Specifically induced upon tunicamycin, DTT as well as rhodanine-3-acetic acid derivative OGT2468 treatment.

559292:YNL237W
gene id: 559292:YNL237W
uniprot id: P53584
names: Subcellular Location Annotation
messages: Membrane

559292:YDL103C
gene id: 559292:YDL103C
uniprot id: P43123
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDPGP type 1 family.
messages: Cytoplasm
messages: Present with 5480 molecules/cell in log phase SD medium.
messages: UDP-N-acetylglucosamine pyrophosphorylase that utilizes N-acetylglucosamine-1-phosphate as substrate (PubMed:9603950). Together with AGM1, is involved in the production of UDP-N-acetylglucosamine from N-acetylglucosamine-6-phosphate (PubMed:9603950).

559292:YBL019W
gene id: 559292:YBL019W
uniprot id: P38207
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.
messages: Nucleus
messages: Present with 414 molecules/cell in log phase SD medium.
messages: Probably binds two magnesium or manganese ions per subunit.

559292:YNL164C
gene id: 559292:YNL164C
uniprot id: P53892
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IBD2 family.
messages: Interacts with BFA1.
messages: Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the G-protein TEM1 by the BFA1/BUB2 complex.
messages: spindle pole

559292:YMR246W
gene id: 559292:YMR246W
uniprot id: P47912
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. Also facilitates the transport of LCFAs into the cell, either by active transport or by decreasing the intracellular LCFA concentration (PubMed:7962057, PubMed:11477098, PubMed:12601005). Contributes, with FAA1, to the activation of imported myristate (PubMed:7962057). Also involved in long-chain base (LCB) uptake. In contrast ot LCFA uptake, LCB uptake does not require ATP, suggesting that the enzyme is directly involved in LCB uptake (PubMed:27136724). Involved in the sphingolipid-to-glycerolipid metabolic pathway, converting the shingolipid metabolite hexadecenoic acid to hexadecenoyl-CoA, which is then further converted to glycerolipids (PubMed:22633490).
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Interacts with FAT1.
messages: Lipid droplet
messages: Present with 31200 molecules/cell in log phase SD medium.
messages: The FACS motif is required for catalytic activity and substrate specificity.

559292:YKL042W
gene id: 559292:YKL042W
uniprot id: P36094
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPC42 family.
messages: Component of the SPC110 complex containing at least CMD1, SPC29, SPC42 and SCP110.
messages: Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.
messages: Nucleus
messages: spindle pole body

559292:YDR213W
gene id: 559292:YDR213W
uniprot id: Q12151
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: ECM22 and UPC2 (in combination) null mutants are not viable.
messages: Induced by anaerobic conditions, hypoxia and cold. Repressed by heme.
messages: Nucleus
messages: Present with 752 molecules/cell in log phase SD medium.
messages: Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation.

559292:YBL072C
gene id: 559292:YBL072C
uniprot id: P0CX39
uniprot id: P0CX40
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 14400 molecules/cell in log phase SD medium.
messages: Present with 15900 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS8 in yeast.

559292:YBR200W
gene id: 559292:YBR200W
uniprot id: P29366
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AXL2 and BUD5.
messages: Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface.
messages: Present with 6490 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YDR284C
gene id: 559292:YDR284C
uniprot id: Q05521
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with LPP1, regulates intracellular DGPP and PA levels, which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. Substrate preference is DGPP > LPA > PA. Activity is independent of a divalent cation ion and insensitive to inhibition by N-ethylmaleimide.
messages: Induced by the transcription factor ZAP1 during zinc depletion and negatively regulated by the transcription factor GIS1 predominantly during nutrient limitation. Induced by inositol supplementation.
messages: Inhibited by sodium fluoride (NaF) and pyrophosphate. Strongly inhibited by manganese ion and, to a lower extent, by magnesium and calcium ions. Also inhibited by Cu(2+) ion. In an indirect manner, it is also inhibited by the zinc ion which is able to form a complex with DGPP and prevent the enzyme from removing the phosphate from the substrate. Not inhibited by N-ethylmaleimide.
messages: Present with 3038 molecules/cell in log phase SD medium.
messages: The phosphatase sequence motif I (including Arg-125) and II (including His-169) are part of the cytoplasmic loop 2 and phosphatase sequence motif III (including His-223) is part of the cytoplasmic loop 3.
messages: Vacuole membrane

559292:YPL259C
gene id: 559292:YPL259C
uniprot id: Q00776
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin. AP57 is probably a subunit of the Golgi membrane adaptor.
messages: Cytoplasmic vesicle
messages: Present with 4420 molecules/cell in log phase SD medium.
messages: clathrin-coated pit
messages: clathrin-coated vesicle membrane

559292:YCR039C
gene id: 559292:YCR039C
uniprot id: P0CY08
uniprot id: P0CY09
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TALE/M-ATYP homeobox family.
messages: Binds DNA with a high specificity as a heterotetramer consisting of an ALPHA2 dimer and an MCM1 dimer. Also binds DNA with a high specificity as a heterodimer of A1 and ALPHA2 in a/alpha diploid cells. Interacts with the general transcription repressor complex SSN6/TUP1.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of ALPHA2 at HML.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that binds cooperatively with MCM1 to a 31-basepair DNA sequence termed the a-specific gene (asg) operator, to repress the transcription of a-cell-specific genes. Additionally, in a/alpha diploid cells, binds cooperatively with the A1 protein to a 21-basepair DNA sequence termed the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1.
messages: Nucleus
messages: Only present in alpha-cells and in a/alpha diploid cells.
messages: The C-terminal tail domain is disordered in the monomer, even when bound to DNA. In the ternary complex with A1 and DNA, 16 residues (Ile-190 to Leu-205) of the C-terminal tail undergo a conformational change, becoming ordered and contacting the A1 homeodomain.
messages: The N-terminal domain is required for the interaction with the WD repeats of TUP1 and for dimerization.
messages: The homeobox domain binds to DNA and interacts with the TPR repeats of SSN6.
messages: The unstructured, flexible linker domain contains eight residues (Leu-114 to Gln-121), which, in the presence of MCM1, adopt a beta-fold and mediate the cooperative interaction to MCM1.
messages: There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.

559292:YPR003C
gene id: 559292:YPR003C
uniprot id: P53394
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Endoplasmic reticulum membrane
messages: Possible sulfate transporter.

559292:YGR252W
gene id: 559292:YGR252W
uniprot id: Q03330
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. SUS1 associates with the SAC3-THP1 complex. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9. Component of the ADA/GCN5 complex, that consists of HFI1/ADA1, ADA2, ADA3, SPT20/ADA5 and GCN5 and is probably a subcomplex of SAGA. Component of the 0.8 MDa ADA complex, which at least consists of ADA2, ADA3, AHC1 and GCN5. GCN5 interacts with ADA2.
messages: Histone acetyltransferase that acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K9ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac and H3K36ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation (PubMed:10026213, PubMed:11545749, PubMed:16543222, PubMed:16543223, PubMed:17189264). Acetylation of histones gives a specific tag for epigenetic transcription activation and elongation (PubMed:10026213, PubMed:11545749, PubMed:16543222, PubMed:16543223, PubMed:17189264, PubMed:19822662). Operates in concert with certain DNA-binding transcriptional activators such as GCN4 or HAP2/3/4 (PubMed:10026213, PubMed:11545749, PubMed:16543222, PubMed:16543223, PubMed:17189264). Its acetyltransferase activity seems to be dependent on the association in different multisubunit complexes (PubMed:10026213, PubMed:11545749, PubMed:16543222, PubMed:16543223, PubMed:17189264). Functions as histone acetyltransferase component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA (PubMed:10026213, PubMed:12186975, PubMed:9154821). SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes (PubMed:10026213). At the promoters, SAGA is required for recruitment of the basal transcription machinery (PubMed:10026213). It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8) (PubMed:10026213). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:10026213). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation (PubMed:121869…
messages: Nucleus
messages: Present with 1180 molecules/cell in log phase SD medium.
messages: Sensitive to amino acid starvation.

559292:YPL015C
gene id: 559292:YPL015C
uniprot id: P53686
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homotrimer. Monomer. Homotrimeric in its unliganded state. Undergoes a trimer-monomer transition upon acetyl-lysine substrate binding.
messages: Inhibited by ADP-ribose and nicotinamide.
messages: NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export.
messages: Nucleus
messages: Present with 5260 molecules/cell in log phase SD medium.

559292:YNL138W
gene id: 559292:YNL138W
uniprot id: P17555
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Homodimer.
messages: Present with 8760 molecules/cell in log phase SD medium.
messages: The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.
messages: actin patch

559292:YJR084W
gene id: 559292:YJR084W
uniprot id: P47130
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN12 family.
messages: Component of a COP9 signalosome-like (CSN) complex, composed of RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In the complex, it probably interacts directly with RRI1/CSN5, CSN9, RRI2/CSN10 and CSI1. Interacts with SEM1 and THP3.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response. CSN12 forms a complex with THP3 that is recruited to transcribed genes and required for transcription elongation.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1510 molecules/cell in log phase SD medium.

559292:YJL168C
gene id: 559292:YJL168C
uniprot id: P46995
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent.
messages: Interacts with the RNA polymerase II hyperphosphorylated CTD. Interacts with CYC8.
messages: Nucleus
messages: Present with 217 molecules/cell in log phase SD medium.
messages: The AWS and SET domains are necessary for transcription repression.

559292:YDR182W
gene id: 559292:YDR182W
uniprot id: P40986
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Binds 2 divalent metal cations.
messages: Membrane
messages: Present with 583 molecules/cell in log phase SD medium.
messages: Probable metallophosphoesterase which may participate in recombinational repair of double -strand breaks.

559292:YKR092C
gene id: 559292:YKR092C
uniprot id: P32583
names: Function
names: Miscellaneous
names: PTM
messages: Not known; weak suppressor of a mutant of the subunit AC40 of DNA dependent RNA polymerase I and III.
messages: Present with 12900 molecules/cell in log phase SD medium.
messages: Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7) (PubMed:15604408). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:15604408, PubMed:17873058).

559292:YLR440C
gene id: 559292:YLR440C
uniprot id: Q12745
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC39 family.
messages: Cells with a reduced level of SEC39 show a defect in post-translational processing of PRC1/CPY.
messages: Component of a peripheral membrane protein complex consisting of DSL1, SEC39/DSL3 and TIP20. Bound to a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6 through direct interaction of TIP20 with SEC20. Interacts with TIP20 and DSL1.
messages: Endoplasmic reticulum membrane
messages: Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex.

559292:YML067C
gene id: 559292:YML067C
uniprot id: Q04651
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERGIC family.
messages: COPII-coated vesicle membrane
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi (PubMed:11157978, PubMed:12426381). The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum (PubMed:12426381). Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (PubMed:12426381).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with ERV46.
messages: Present with 3000 molecules/cell in log phase SD medium.

559292:YMR013C
gene id: 559292:YMR013C
uniprot id: P20048
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyprenol kinase family.
messages: Endoplasmic reticulum membrane
messages: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. It is required for spore germination. Has an essential role in cellular metabolism.

559292:YOR341W
gene id: 559292:YOR341W
uniprot id: P10964
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
messages: Present with 2840 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YCL005W
gene id: 559292:YCL005W
uniprot id: P25587
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Lipid droplet
messages: May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.
messages: Membrane
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YDL166C
gene id: 559292:YDL166C
uniprot id: Q12055
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity (By similarity). Involved in 18S rRNA maturation. Required for cleavage of the 20S pre-rRNA at site D in the cytoplasm. Involved in oxidative stress response. Required for POS9-dependent target gene transcription upon oxidative stress.
messages: Cytoplasm
messages: Interacts with RPS14B. Not a structural component of 43S pre-ribosomes, but transiently interacts with them with them by binding to RPS14.
messages: Nucleus
messages: Present with 8350 molecules/cell in log phase SD medium.

559292:YNR076W
gene id: 559292:YNR076W
uniprot id: P0CE90
uniprot id: P0CE91
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YLR431C
gene id: 559292:YLR431C
uniprot id: Q06671
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG23 family.
messages: Cytoplasm
messages: Forms a complex with ATG9 and ATG27.
messages: Membrane
messages: Preautophagosomal structure membrane
messages: Present with 538 molecules/cell in log phase SD medium.
messages: Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Also plays a role in regulation of filamentous growth.

559292:YCR054C
gene id: 559292:YCR054C
uniprot id: P25355
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTR86 family.
messages: Cytoplasm
messages: Essential protein which may be involved in threonine biosynthesis.
messages: Present with 8970 molecules/cell in log phase SD medium.

559292:YLR204W
gene id: 559292:YLR204W
uniprot id: P32344
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). mS38 is also involved in the splicing of the COX1 mRNA (PubMed:16339141).
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Mitochondrion inner membrane

559292:YHR021C
gene id: 559292:YHR021C
uniprot id: P38711
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: The N-terminus is not modified.
messages: There are 2 genes for eS27 in yeast.

559292:YER151C
gene id: 559292:YER151C
uniprot id: Q01477
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin (PubMed:12778054, PubMed:17632125). Plays a role in regulation of silencing by interacting with SIR4 (PubMed:8752220). Also, in conjunction with BRE5, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of SEC23 (PubMed:12778054). Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation (PubMed:20508643).
messages: Heterotetramer with BRE5; contains two molecules of BRE5 and two molecules of UBP3 (PubMed:12778054, PubMed:17632125). Forms a complex composed of CDC48, DOA1, deubiquitinase UBP3 and probably BRE5. Within the complex interacts directly with DOA1 and CDC48 in a BRE5-independent manner (PubMed:20508643).
messages: Present with 2210 molecules/cell in log phase SD medium.

559292:YGR284C
gene id: 559292:YGR284C
uniprot id: P53337
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal di-lysine motif is required for exit from the endoplasmic reticulum. Required directly for packaging glycosylated pro-alpha-factor into COPII vesicles. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

559292:YML098W
gene id: 559292:YML098W
uniprot id: P11747
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF13 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: In TFIID, TAF13 heterodimerizes with TAF11, but they do not seem to form a heterotetramer like TAF6/TAF9. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.
messages: Nucleus
messages: Present with 2100 molecules/cell in log phase SD medium.

559292:YBL034C
gene id: 559292:YBL034C
uniprot id: P38198
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLASP family.
messages: Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for separation of the spindle poles during mitotic spindle formation. May cross-link overlapping antiparallel microtubules in the spindle midzone.
messages: Nucleus
messages: Present with 521 molecules/cell in log phase SD medium.
messages: Self-associates. Interacts with microtubules via the TUB2 subunit.
messages: cytoskeleton
messages: kinetochore
messages: spindle

559292:YIR005W
gene id: 559292:YIR005W
uniprot id: P40565
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IST3 family.
messages: Cells have a slow growth phenotype that is exacerbated at 37 degrees Celsius. Deletion mutants have a significant pre-mRNA leakage at 25 degrees Celsius.
messages: Component of the 45S U1.U2.U4/U6.U5 penta-snRNP particle, a subcomplex of the spliceosome. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Belongs to the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3 and PML1. Subunit of the U2 snRNP. Interacts with RDS3.
messages: Cytoplasm
messages: Nucleus
messages: Present with 922 molecules/cell in log phase SD medium.
messages: Required for pre-mRNA splicing and spliceosome assembly. As part of the pre-mRNA retention and splicing (RES) complex, required for nuclear pre-mRNA retention and efficient splicing. Required for MER1-activated splicing.

559292:YJL194W
gene id: 559292:YJL194W
uniprot id: P09119
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ORC complex and the MCM2-7 helicase complex. Interacts with CDC4, CDC28, DIA2, ORC1, and TOM1.
messages: Belongs to the CDC6/cdc18 family.
messages: Chromosome
messages: Nucleus
messages: Phosphorylated by CDC28. Phosphorylation is a prerequisite to ubiquitination and degradation.
messages: Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division.
messages: Transcribed at the end of mitosis, but in cells with a prolonged G1 phase there is a second burst of transcription in late G1.
messages: Ubiquitinated by the E3 ubiquitin ligase complex SCF(CDC4), DIA2, and TOM1; and targeted to the 26S proteasome for degradation.

559292:YGR236C
gene id: 559292:YGR236C
uniprot id: P50088
names: Induction
names: Subcellular Location Annotation
messages: Abundant in stationary phase (G0) cells. mRNA levels rapidly decrease upon exit from G0.
messages: Mitochondrion membrane

559292:YFL061W
gene id: 559292:YFL061W
uniprot id: P0CH63
uniprot id: P0CH64
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the cyanamide dehydrase family.
messages: Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment.
messages: DDI2 and DDI3 are duplicated genes located on different chromosomes, with identical ORF sequences and only one nucleotide difference in their promoter (up to 1 kb) regions.
messages: Expression is induced by DNA-damaging agents such as methyl methanesulfonate (MMS) or dimethyl sulfate (DMS) (PubMed:18485869, PubMed:25847245). Massively induced by cyanamide (PubMed:25847245).
messages: Homohexamer.
messages: The double deletion of DDI2 and DDI3 compromizes cellular resistance to cyanamide by impairing its metabolization.

559292:YOR275C
gene id: 559292:YOR275C
uniprot id: Q12033
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the palA/RIM20 family.
messages: Cytoplasm
messages: Interacts with SNF7 with its BRO1 domain. Interacts with RIM101 with its C-terminal domain, probably binding to its two YPX[LI] motifs.
messages: Nucleus
messages: Present with 2881 molecules/cell in log phase SD medium.
messages: Required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH, which is necessary for sporulation and invasive growth. May act as a scaffold protein that recruits the calpain-like protease RIM13 via SNF7 to its substrate RIM101.

559292:YLR259C
gene id: 559292:YLR259C
uniprot id: P19882
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chaperonin (HSP60) family.
messages: May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins.
messages: Mitochondrion matrix

559292:YOR336W
gene id: 559292:YOR336W
uniprot id: P22023
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen
messages: Present with 815 molecules/cell in log phase SD medium.
messages: Required for (1->6)-beta-D-glucan synthesis and normal cell growth.
messages: To D.melanogaster UGGG.

559292:YJR063W
gene id: 559292:YJR063W
uniprot id: P32529
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Interacts with RPA2/RPA135. Peripheral subunit that binds the catalytic zinc ion that is required for RNA cleavage. The heterodimer formed by RPA34 and RPA49 stabilizes subunit RPA12 and stimulates RPA12-dependent RNA cleavage. Involved in the recruitment of RPA49 to Pol I.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Proposed to contribute to the polymerase catalytic activity and form the polymerase active center together with the two largest subunits. Subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. Involved in transcriptional termination.
messages: Present with 8450 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YJR053W
gene id: 559292:YJR053W
uniprot id: P47113
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with BUB2.
messages: Multiply phosphorylated in a cell-cycle-dependent manner with the major phosphorylation occurring in mitosis.
messages: Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the G-protein TEM1 by the BFA1/BUB2 complex.
messages: Present with 1380 molecules/cell in log phase SD medium.
messages: To S.pombe byr4.
messages: spindle pole

559292:YPR010C-A
gene id: 559292:YPR010C-A
uniprot id: A5Z2X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0495 family.
messages: Cytoplasm
messages: Membrane

559292:YGL223C
gene id: 559292:YGL223C
uniprot id: P53079
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
messages: Belongs to the COG1 family.
messages: Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.
messages: Golgi apparatus membrane
messages: Present with 2190 molecules/cell in log phase SD medium.

559292:YOR157C
gene id: 559292:YOR157C
uniprot id: P25043
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 11400 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
messages: The side chain of Thr-30 acts as nucleophile, and the N-terminal amino group acts as proton acceptor.

559292:YJR146W
gene id: 559292:YJR146W
uniprot id: P47174
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 952 molecules/cell in log phase SD medium.

559292:YPL079W
gene id: 559292:YPL079W
uniprot id: Q12672
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL21 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 66400 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL21 in yeast.

559292:YOR045W
gene id: 559292:YOR045W
uniprot id: P33448
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom6 family.
messages: Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM6 is involved in assembly and stability of the TOM complex.
messages: Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70).
messages: Mitochondrion outer membrane

559292:YOR305W
gene id: 559292:YOR305W
uniprot id: Q08774
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG7 family.
messages: Impaired respiratory growth and sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO).
messages: Mitochondrion
messages: Present with 1420 molecules/cell in log phase SD medium.

559292:YDL040C
gene id: 559292:YDL040C
uniprot id: P12945
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the N-terminal acetyltransferase A (NatA) complex, which is composed of ARD1, NAT1 and NAT5. Can self-associate. NAT1 associates with the nascent polypeptide chain and the ribosome.
messages: Cytoplasm
messages: Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation.
messages: Present with 7600 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YNL283C
gene id: 559292:YNL283C
uniprot id: P53832
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: N-glycosylated.

559292:YNL331C
gene id: 559292:YNL331C
uniprot id: P42884
names: Similarity
messages: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

559292:YDR534C
gene id: 559292:YDR534C
uniprot id: Q04433
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: By iron.
messages: Involved in the uptake of non-siderophore sources of iron and the siderophores ferrioxamine B and ferrichrome. Has a role in the retention of iron in the cell wall and periplasmic space.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
messages: cell wall

559292:YLR119W
gene id: 559292:YLR119W
uniprot id: Q99176
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of STP22, VPS28, SRN2 and MVB12 in a 1:1:1:1 stoichiometry. Interacts with STP22 and MVB12.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for normal endocytic and biosynthetic traffic to the yeast vacuole.
messages: Cytoplasm
messages: Endosome
messages: Late endosome membrane

559292:YAL001C
gene id: 559292:YAL001C
uniprot id: P34111
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with TFC1, TFC4 and TFC6.
messages: Mitochondrion
messages: Nucleus
messages: Present with 125 molecules/cell in log phase SD medium.
messages: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding.

559292:YBL103C
gene id: 559292:YBL103C
uniprot id: P38165
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a heterodimer with RTG1.
messages: Nucleus
messages: Present with 1050 molecules/cell in log phase SD medium.
messages: Transcription factor that regulates CIT2 gene expression. Binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (UASR) in the CIT2 promoter. The core binding site is 5'-GGTCAC-3'.
messages: the 9aaTAD motifs are transactivation domains present in a large number of yeast and animal transcription factors.

559292:YER021W
gene id: 559292:YER021W
uniprot id: P40016
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S3 family.
messages: N-acetylated by NAT1.
messages: Present with 16700 molecules/cell in log phase SD medium.
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).

559292:YGR074W
gene id: 559292:YGR074W
uniprot id: Q02260
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: C-terminal extension may function as a nuclear localization signal (NLS).
messages: Component of the Sm core complex, present in spliceosomal snRNP U1, U2, U4/U6 and U5. The core complex contains SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively), and is probably a heptameric ring structure. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2400 molecules/cell in log phase SD medium.
messages: lays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:8430095). Also binds telomerase RNA and is required for its accumulation (PubMed:10490028).

559292:YMR171C
gene id: 559292:YMR171C
uniprot id: Q03212
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSH4 family.
messages: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
messages: Endosome membrane
messages: Present with 656 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YDR074W
gene id: 559292:YDR074W
uniprot id: P31688
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: By heat shock. Repressed by glucose.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.
messages: Inhibited by EDTA.
messages: Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process.
messages: Present with 22700 molecules/cell in log phase SD medium.
messages: The trehalose synthase complex is composed of the two catalytic subunits TPS1 and TPS2, and at least one of the two regulatory subunits TPS3 or TSL1.

559292:YDR235W
gene id: 559292:YDR235W
uniprot id: Q03776
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 18S U1 snRNP particle, a subcomplex of the spliceosome.
messages: Essential component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. U1 snRNP is cotranscriptionally recruited to intron-containing genes. Required for U1 snRNP biogenesis.
messages: Nucleus
messages: Present with 1730 molecules/cell in log phase SD medium.

559292:YKL170W
gene id: 559292:YKL170W
uniprot id: P35996
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 2500 molecules/cell in log phase SD medium.

559292:YGL124C
gene id: 559292:YGL124C
uniprot id: P53129
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MON1/SAND family.
messages: Forms a complex with CCZ1.
messages: In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking (PubMed:12134085, PubMed:12364329, PubMed:12387888, PubMed:14662743, PubMed:15721293). The CCZ1-MON1 complex acts as a guanine nucleotide-exchange factor (GEF) for Rab-type GTPase YPT7, promoting nucleotide exchange on YPT7 and triggering endosomal maturation by activating YPT7 on late endosomes (PubMed:20797862).
messages: Prevacuolar compartment membrane
messages: Vacuole membrane
messages: multivesicular body membrane

559292:YDR315C
gene id: 559292:YDR315C
uniprot id: Q06667
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPK1 type 1 family.
messages: Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
messages: Nucleus
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

559292:YGL036W
gene id: 559292:YGL036W
uniprot id: P53185
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 486 molecules/cell in log phase SD medium.

559292:YFR049W
gene id: 559292:YFR049W
uniprot id: P19955
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the mitochondrial small ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).
messages: Mitochondrion
messages: Present with 2050 molecules/cell in log phase SD medium.

559292:YER058W
gene id: 559292:YER058W
uniprot id: Q02771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Involved in the assembly of cytochrome c oxidase.
messages: Mitochondrion

559292:YDL201W
gene id: 559292:YDL201W
uniprot id: Q12009
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Forms a complex with TRM82.
messages: Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity.
messages: Nucleus
messages: Present with 2630 molecules/cell in log phase SD medium.

559292:YJL203W
gene id: 559292:YJL203W
uniprot id: P32524
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Nucleus
messages: Present with 2490 molecules/cell in log phase SD medium.
messages: mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.

559292:YGR144W
gene id: 559292:YGR144W
uniprot id: P32318
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THI4 family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: During the catalytic reaction, a sulfide is transferred from Cys-205 to a reaction intermediate, generating a dehydroalanine residue.
messages: Expressed at high levels in the early stationary phase of batch cultures growing on molasses, an industrial medium.
messages: Homooctamer; tetramer of dimers.
messages: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
messages: Nucleus
messages: Repressed by thiamine.

559292:YBR181C
gene id: 559292:YBR181C
uniprot id: P0CX37
uniprot id: P0CX38
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS6 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). Interacts with snoRNA U3. uS11 interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).
messages: Cytoplasm
messages: Present with 38800 molecules/cell in log phase SD medium.
messages: Present with 66000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS6 in yeast.
messages: nucleolus

559292:YNR062C
gene id: 559292:YNR062C
uniprot id: P53748
names: Subcellular Location Annotation
messages: Membrane

559292:YGL229C
gene id: 559292:YGL229C
uniprot id: P53036
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Associates with the SIT4 phosphatase in a cell cycle dependent manner. May be directly or indirectly involved in SIT4-dependent functions in budding and in normal G1 cyclin expression (By similarity).
messages: Belongs to the SAPS family.
messages: Hyperphosphorylated in the absence of SIT4.
messages: Present with 279 molecules/cell in log phase SD medium.

559292:YKL056C
gene id: 559292:YKL056C
uniprot id: P35691
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCTP family.
messages: Interacts with the 40S and 60S ribosomal subunits. Interacts with microtubules.
messages: Involved in protein synthesis. Involved in microtubule stabilization.
messages: Mitochondrion
messages: Present with 27800 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YOL028C
gene id: 559292:YOL028C
uniprot id: Q08182
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. YAP subfamily.
messages: Homodimer.
messages: Nucleus
messages: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
messages: Present with 1700 molecules/cell in log phase SD medium.
messages: Probable transcription activator linked to cell cycle that induces transcription activation of genes in the environmental stress response and metabolism control pathways, like the closely related YAP5.

559292:YLR443W
gene id: 559292:YLR443W
uniprot id: Q06200
names: Function
names: Induction
names: Subcellular Location Annotation
messages: May be involved in cell wall organization and biogenesis.
messages: Membrane
messages: Repressed by zinc.

559292:YHR020W
gene id: 559292:YHR020W
uniprot id: P38708
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

559292:YNR003C
gene id: 559292:YNR003C
uniprot id: P32910
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with BRF1/TDS4.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in recruitment of Pol III to the preinitiation complex. Involved in the configuration of an initiation-competent form of RNA polymerase.
messages: Nucleus

559292:YJL172W
gene id: 559292:YJL172W
uniprot id: P27614
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Glycosylated.
messages: Necessary for use of certain peptides as sole nitrogen source. May also cleave intracellularly generated peptides to recycle amino acids for protein synthesis.
messages: Present with 721 molecules/cell in log phase SD medium.
messages: The transmembrane domain contains polar residues that mediate the recognition by TUL1.
messages: Ubiquitinated. Ubiquitination mediates sorting into internal vesicles in late endosomes. TUL1 is required for ubiquitination.
messages: Vacuole membrane
messages: yscS is synthesized as one polypeptide chain precursor which after carbohydrate modification in the secretory pathway yields two active precursor molecules. The proteolytically unprocessed forms are associated with the membrane, whereas the mature forms of the enzyme are soluble.

559292:YER122C
gene id: 559292:YER122C
uniprot id: P38682
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum.
messages: Golgi apparatus
messages: Present with 1510 molecules/cell in log phase SD medium.

559292:YGR086C
gene id: 559292:YGR086C
uniprot id: P53252
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Lipid droplet
messages: Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.
messages: Phosphorylated by PKH1 and PKH2. Phosphorylation is inhibited by sphingolipid long chain bases (LCBs).
messages: Present with 2157 molecules/cell in log phase SD medium.

559292:YGL206C
gene id: 559292:YGL206C
uniprot id: P22137
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. In yeast, it is involved in the retention of proteins in an intracellular membrane compartment, presumably the trans-Golgi.
messages: Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. Interacts with the auxilin-like clathrin uncoating factor SWA2. Interacts with INP53.
messages: Cytoplasmic vesicle membrane
messages: Present with 28700 molecules/cell in log phase SD medium.
messages: The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
messages: The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity).
messages: coated pit

559292:YBL097W
gene id: 559292:YBL097W
uniprot id: P38170
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.
messages: Cytoplasm
messages: Nucleus
messages: Present with 704 molecules/cell in log phase SD medium.
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.

559292:YNL010W
gene id: 559292:YNL010W
uniprot id: P53981
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Cytoplasm
messages: Hydrolyzes sugar alcohol (polyol) phosphates (PubMed:30240188). Dephosphorylates a variety of substrates, including: sn-glycerol 1-phosphate (D-glycerol 3-phosphate), D-ribitol 5-phosphate, D-sorbitol 6-phosphate (D-glucitol 6-phosphate), and D-erythrose 4-phosphate (PubMed:30240188). Prevents accumulation of toxic levels of polyol phosphates, which can impair glycolysis by inhibiting glucose-6-phosphate isomerase (PubMed:30240188).
messages: Impairs the ability to metabolize cellular polyol phosphates which may build up to toxic levels in cells.
messages: Nucleus
messages: Present with 12600 molecules/cell in log phase SD medium.
messages: Unlike the glycerol-1-phosphate phosphohydrolases, this enzyme cannot hydrolyze L-glycerol 3-phosphate (sn-glycerol 3-phosphate) and is therefore not associated with EC 3.1.3.21 / RHEA:11476.

559292:YOL144W
gene id: 559292:YOL144W
uniprot id: Q08287
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with NIP7 and RRP43. Together with DBP6, URB1, URB2 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.
messages: Present with 2170 molecules/cell in log phase SD medium.
messages: Required for 60S ribosomal subunit synthesis. May be involved in assembly reactions occurring within late pre-ribosomal particles.
messages: nucleolus

559292:YDL085W
gene id: 559292:YDL085W
uniprot id: Q07500
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE1, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxidation.
messages: Mitochondrion intermembrane space

559292:YFR039C
gene id: 559292:YFR039C
uniprot id: P43611
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: A combined deletion of the OSW7 and SHE10 has reduced dityrosine incorporation in the outer spore wall.
messages: Belongs to the OSW/SHE family.
messages: Involved in spore wall assembly.
messages: Present with 3170 molecules/cell in log phase SD medium.

559292:YDR104C
gene id: 559292:YDR104C
uniprot id: Q03868
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal prospore membrane formation (PubMed:22611022, PubMed:24036347). Abolishes localization of VPS13 to the prospore membrane (PubMed:24036347). Accumulation of vesicles within the prospore membrane lumen and reduction of phosphatidylinositol in the membrane (PubMed:24036347). Abnormal spore wall formation; the first three layers are synthesized but abnormally deposited and the dityrosine layer is missing (PubMed:22611022). Sporulation specific septins are mislocalized (PubMed:22611022).
messages: Belongs to the SPO71 family.
messages: Expressed during sexual reproduction; expression increases during meiosis II (at protein level).
messages: Interacts (via PxP motif) with VPS13 (via SHR-BD domain); during prospore membrane formation.
messages: Prospore membrane
messages: Recruits the lipid transfer protein VPS13 to the prospore membrane during sporulation, thereby aiding prospore membrane formation.

559292:YIR010W
gene id: 559292:YIR010W
uniprot id: P40568
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.
messages: Component of the MIND kinetochore complex, which is composed of at least MTW1, NNF1, NSL1 and DSN1. Interacts with NSL1.
messages: Nucleus
messages: Present with 1310 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YPL277C
gene id: 559292:YPL277C
uniprot id: Q08989
names: PTM
messages: N-glycosylated.

559292:YKL023C-A
gene id: 559292:YKL023C-A
uniprot id: Q2V2P3
names: Subcellular Location Annotation
messages: Membrane

559292:YHR056C
gene id: 559292:YHR056C
uniprot id: P38781
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is required for transcription of ribosomal protein genes and genes involved in the integrity of the cell wall. Together with HTL1, LDB7, NPL6, RSC3 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity.
messages: Forms a heteromer with RSC3. Interacts with NPL6. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Component of a fungal-specific module (HTL1-LDB7-NPL6-RSC3-RSC30) within the RSC complex.
messages: Nucleus

559292:YOL117W
gene id: 559292:YOL117W
uniprot id: Q12348
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a COP9 signalosome-like (CSN) complex, composed of at least RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In the complex, it probably interacts directly with CSN12.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1320 molecules/cell in log phase SD medium.

559292:YFR055W
gene id: 559292:YFR055W
uniprot id: P43623
names: Miscellaneous
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.
messages: Present with 2610 molecules/cell in log phase SD medium.

559292:YMR223W
gene id: 559292:YMR223W
uniprot id: P50102
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. UBP8 subfamily.
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. UBP8 interacts with SGF11. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, TAF10 and TAF9.
messages: Functions as histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. Together with SGF11, is required for histone H2B deubiquitination.
messages: Nucleus
messages: Present with 1030 molecules/cell in log phase SD medium.
messages: The UBP-type zinc finger domain is required for the interaction with the SAGA complex.

559292:YJR052W
gene id: 559292:YJR052W
uniprot id: P06779
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Component of the global genome repair (GGR) complex composed of at least ABF1, RAD7 and RAD16 (PubMed:10601031). Interacts with ELC1 (PubMed:19920177).
messages: Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. This protein is one of 10 proteins (RAD1, 2,3,4,7,10,14, 16,23 and MMS19) involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
messages: Mutants with mutations in the RAD7, RAD14, RAD16, and RAD23 genes show partial incision defectiveness.
messages: Present with 937 molecules/cell in log phase SD medium.
messages: To S.pombe SpCC613.14.

559292:YHR148W
gene id: 559292:YHR148W
uniprot id: P32899
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.
messages: nucleolus

559292:YDR177W
gene id: 559292:YDR177W
uniprot id: P21734
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: By heat shock and cadmium.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).
messages: Early stages of growth after spore germination.
messages: Present with 8940 molecules/cell in log phase SD medium.

559292:YAL027W
gene id: 559292:YAL027W
uniprot id: P39735
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Accumulates recombination intermediates blocked at the RAD1/RAD10-dependent 3' flap cleavage step. Abolishes association of RAD1 at single-strand annealing (SSA) intermediates. Insensitive to MMS, HU, or phleomycin treatment. Doesn't sensitize cells to UV lesions. Substantially increases the rDNA recombination rate.
messages: Catalyzes 3'-non-homologous tail removal of RAD1/RAD10-dependent single-strand annealing recombination intermediates. Plays a key role in targeting RAD1/RAD10 complex to 3'-flap cleavage substrate in recombination. Also contributes to the integrity of ribosomal DNA arrays.
messages: Interacts with MSH2, MSH3, RAD1, RAD10, RAD51 and RAD52.
messages: Nucleus
messages: Present with 1170 molecules/cell in log phase SD medium.

559292:YIL144W
gene id: 559292:YIL144W
uniprot id: P40460
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25. The NDC80 complex is formed by two subcomplexes, NDC80-NUF2 and SPC24-SPC25, which are joined end-to-end through their coiled-coil domains. It has a rod-like structure with a length of 570 Angstroms and globular domains at either end. The NDC80-NUF2 globular domains are probably directed to microtubules, the SPC24-SPC25 globular domains to the centromere. NDC80 probably interacts with SMC1 and SMC2. Also interacts with KIN3. Interacts with DMC1.
messages: Nucleus
messages: Present with 1160 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YGR243W
gene id: 559292:YGR243W
uniprot id: P53311
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Grows more slowly in amino acid-free medium (SD), when combined with disruption of MPC2.
messages: Mainly expressed when grown on lactate containing growth medium (PubMed:22628554). Expression regulated by osmotic and alkaline stresses (PubMed:15299026, PubMed:16087739, PubMed:17334841). Under the control of the SKO1 transcription factor (PubMed:16087739).
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 6750 molecules/cell in log phase SD medium.
messages: The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and either MPC2 or MPC3.

559292:YNL200C
gene id: 559292:YNL200C
uniprot id: P40165
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Cytoplasm
messages: Mitochondrion
messages: Present with 1380 molecules/cell in log phase SD medium.

559292:YPL026C
gene id: 559292:YPL026C
uniprot id: Q12505
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: May have a role in glucose regulation.
messages: Present with 2810 molecules/cell in log phase SD medium.

559292:YMR226C
gene id: 559292:YMR226C
uniprot id: Q05016
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Homotetramer.
messages: NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate.
messages: Nucleus
messages: Present with 3210 molecules/cell in log phase SD medium.

559292:YPR156C
gene id: 559292:YPR156C
uniprot id: Q06451
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
messages: By transcription factor HAA1 in response to acetaldehyde accumulation.
messages: Cell membrane
messages: Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermine, but not spermidine.
messages: Present with 2760 molecules/cell in log phase SD medium.

559292:YPL060W
gene id: 559292:YPL060W
uniprot id: Q02783
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Forms homooligomers. Interacts with MRS2.
messages: Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.
messages: Mitochondrion inner membrane
messages: N-glycosylated. Glycosylation is important for correct localization of the protein.
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YLR309C
gene id: 559292:YLR309C
uniprot id: Q06704
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: By cold.
messages: Cytoplasm
messages: Forms oligomers and is present in high-molecular-mass complexes. Interacts with ARL1.
messages: Golgi apparatus membrane
messages: Involved in vesicular transport between an endosomal compartment and the Golgi apparatus.
messages: Present with 2350 molecules/cell in log phase SD medium.
messages: The GRIP domain may serve as a Golgi targeting domain through its interaction with the ARL1 Golgi protein.

559292:YNL088W
gene id: 559292:YNL088W
uniprot id: P06786
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Homodimer.
messages: In yeast topoisomerase II can substitute topoisomerase I for the relaxing activity.
messages: Nucleus
messages: Phosphorylation enhances the activity. Stimulates decatenation activity.
messages: Present with 5730 molecules/cell in log phase SD medium.

559292:YKL134C
gene id: 559292:YKL134C
uniprot id: P35999
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane. Cleaves precursor proteins of respiratory components, including subunits of the electron transport chain and tricarboxylic acid cycle enzymes, and components of the mitochondrial genetic machinery, including ribosomal proteins, translation factors, and proteins required for mitochondrial DNA metabolism.
messages: Mitochondrion matrix
messages: Present with 2690 molecules/cell in log phase SD medium.
messages: Simultaneous disruption of the mitochondrial presequence protease CYM1 results in synthetic lethality in respiratory conditions.
messages: Stimulated by Fe(2+).

559292:YDR076W
gene id: 559292:YDR076W
uniprot id: P38953
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD55 subfamily.
messages: Nucleus
messages: Present with 1050 molecules/cell in log phase SD medium.
messages: Required for radiation resistance and meiotic viability and presumably acts in recombination and recombinational DNA repair pathways.

559292:YBR146W
gene id: 559292:YBR146W
uniprot id: P38120
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion

559292:YGL154C
gene id: 559292:YGL154C
uniprot id: P50113
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity.
messages: Present with 623 molecules/cell in log phase SD medium.

559292:YPR110C
gene id: 559292:YPR110C
uniprot id: P07703
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34 (PubMed:8516295, PubMed:11717393, PubMed:12407181, PubMed:18160037, PubMed:24153184, PubMed:24153182). The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase III (Pol III) complex consisting of at least 17 subunits (PubMed:8516295, PubMed:10384303, PubMed:10393904). Interacts with the RPC19/RPAC2 (PubMed:8516295) and RPC53/RPC4 (PubMed:10393904). Interacts with retrotransposons Ty integrase, targeting Ty1, Ty2 and Ty4 integration upstream of pol III-transcribed genes (PubMed:25931562).
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I (Pol I) and III (Pol III) which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPC40 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (PubMed:18160037, PubMed:24153182, PubMed:24153184). Plays an important role in targeting retrotransposons Ty integration upstream of pol III-transcribed genes such as tRNA genes, allowing Ty1, Ty2 and Ty4 to proliferate and yet minimizing genetic damage (PubMed:25931562).
messages: Present with 13000 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YER089C
gene id: 559292:YER089C
uniprot id: P39966
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Present with 12600 molecules/cell in log phase SD medium.
messages: Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.

559292:YNR029C
gene id: 559292:YNR029C
uniprot id: P53729
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
messages: Impaired response to zinc deficiency.
messages: Present with 1560 molecules/cell in log phase SD medium.
messages: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (PubMed:35584675). Catalyzes zinc insertion into the active site of methionine aminopeptidase MAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584675). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of MAP1 (PubMed:35584675). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of MAP1 in a process requiring GTP hydrolysis (PubMed:35584675). GTP/GDP exchange is required for release of active MAP1 (PubMed:35584675).

559292:YPR011C
gene id: 559292:YPR011C
uniprot id: Q12251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane

559292:YHR136C
gene id: 559292:YHR136C
uniprot id: P38839
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Present with 2180 molecules/cell in log phase SD medium.
messages: Putative cyclin-dependent kinase (CDK) inhibitor necessary and sufficient for PHO pathway-dependent down-regulation of low-affinity phosphate transport.
messages: Regulated by phosphate, probably through its PHO4-binding elements in the promoter.

559292:YJR015W
gene id: 559292:YJR015W
uniprot id: P47090
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 639 molecules/cell in log phase SD medium.
messages: To yeast SNG1.

559292:YPR018W
gene id: 559292:YPR018W
uniprot id: Q12495
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p90 may facilitate the efficient and timely assembly of histones into telomeric chromatin.
messages: Belongs to the RLF2 family.
messages: Component of chromatin assembly factor 1 (CAF-1), which is composed of MSI1/p50, CAC2/p60 and RLF2/CAC1/p90. RLF2 interacts with SAS2.
messages: Nucleus
messages: Present with 1590 molecules/cell in log phase SD medium.

559292:YLR144C
gene id: 559292:YLR144C
uniprot id: Q12168
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 81 family.
messages: Cleaves internal linkages in 1,3-beta-glucan.
messages: Cytoplasm
messages: Inhibited by mercury ions.
messages: Present with 1420 molecules/cell in log phase SD medium.

559292:YPL221W
gene id: 559292:YPL221W
uniprot id: Q08967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Endoplasmic reticulum membrane
messages: May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.

559292:YOR164C
gene id: 559292:YOR164C
uniprot id: Q12125
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GET4 family.
messages: Cytoplasm
messages: Interacts with MDY2/GET5.
messages: May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
messages: Present with 5350 molecules/cell in log phase SD medium.

559292:YJL089W
gene id: 559292:YJL089W
uniprot id: P46954
names: Function
names: Subcellular Location Annotation
messages: Interacts with the SNF1 protein kinase.
messages: Nucleus

559292:YJL173C
gene id: 559292:YJL173C
uniprot id: P26755
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism (By similarity). Stimulates the activity of a cognate strand exchange protein (SEP1).
messages: Belongs to the replication factor A protein 3 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YOR175C
gene id: 559292:YOR175C
uniprot id: Q08548
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Broad specificity membrane-bound O-acyltransferase that mediates the incorporation of unsaturated acyl chains into the sn-2 position of various lysophospholipids. Preferentially acylates lysophosphocholine (LPC), but also lysophosphoethanolamine (LPE), lysophosphatidylglycerol (LPG), lysophosphatidic acid (LPA), lysophosphoethanolamine (LPE), lysophosphoinositol (LPI), and lysophosphoserine (LPS) (PubMed:17996202, PubMed:17652094, PubMed:17726007, PubMed:17675291, PubMed:17890783). Prefers an acyl residue to an alkyl residue at the sn-1 position of lysophospholipid acceptors. Accepts acyl chains in acyl-CoA from C-2 to C-20, and shows strong preference for unsaturated acyl-CoAs with 16-20 carbons (PubMed:17890783). Together with SLC1, plays a central role in phosphatidic acid (PA) biosynthesis. PA is the intermediate, from which all glycerophospholipids are synthesized (PubMed:17890783). Can also introduce an acyl chain at the sn-1 position of the lysophosphatidylcholine analog 1-hydroxy-2-hexadecyl-sn-glycero-3-phosphocholine (HHPC) (PubMed:29782033).
messages: Endoplasmic reticulum membrane

559292:YGR167W
gene id: 559292:YGR167W
uniprot id: P17891
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the clathrin light chain family.
messages: CLC1 binds calcium, and calmodulin in presence of calcium.
messages: Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with the auxilin-like clathrin uncoating factor SWA2.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. In yeast, it is involved in the retention of proteins in an intracellular membrane compartment, presumably the trans-Golgi. The yeast light chain is important for cell growth. The light chain may help to properly orient the assembly/ disassembly of the clathrin coats.
messages: Cytoplasmic vesicle membrane
messages: Present with 3490 molecules/cell in log phase SD medium.
messages: coated pit

559292:YOL155C
gene id: 559292:YOL155C
uniprot id: Q05164
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Erroneous sequence assembling in the Ser-rich region leading to a longer sequence.
messages: Involved in cell wall organization and biosynthesis.
messages: Membrane
messages: Probable mannoprotein called haze protective factor from wine that is able to prevent visible wine protein haze formation. This mannoprotein showed haze-protective activity against wine proteins and BSA when either was heated in white wine.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
messages: cell wall

559292:YDR540C
gene id: 559292:YDR540C
uniprot id: Q03036
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YDR371W
gene id: 559292:YDR371W
uniprot id: Q06350
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.
messages: Present with 3050 molecules/cell in log phase SD medium.
messages: Secreted

559292:YOR224C
gene id: 559292:YOR224C
uniprot id: P20436
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Directly interacts with POLR2A.
messages: DNA-dependent RNA polymerases catalyze the transcription. of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
messages: Nucleus
messages: Present with 6210 molecules/cell in log phase SD medium.

559292:YOR213C
gene id: 559292:YOR213C
uniprot id: Q99314
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing. In the complex, SAS5 is required for maximal histone acetyltransferase (HAT) activity of the complex, suggesting that it may be required to stabilize the complex or help in substrate recognition.
messages: Component of the SAS complex, at least composed of SAS2, SAS4 and SAS5. These three proteins constitute the core of the complex, and are sufficient to acetylate histones.
messages: Heterochromatin spreading downstream of the silent mating-type locus HMR.
messages: Nucleus
messages: Present with 1800 molecules/cell in log phase SD medium.

559292:YKL104C
gene id: 559292:YKL104C
uniprot id: P14742
names: Function
names: Induction
names: Miscellaneous
messages: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
messages: Present with 14300 molecules/cell in log phase SD medium.
messages: The activity of this enzyme increases in presence of mating pheromone (transcriptional regulation).

559292:YMR197C
gene id: 559292:YMR197C
uniprot id: Q04338
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTI1 family.
messages: Forms SNARE complexes with the t-SNAREs VAM3 and VAM7, and the v-SNAREs NYV1 and YKT6 on vacuolar membranes, which are involved in biosynthetic transport pathways to the vacuole and in homotypic vacuole fusion. Forms SNARE complexes with the cis-Golgi t-SNARE SED5 and the v-SNAREs SFT1 and YTK6, which are involved in retrograde traffic to the cis-Golgi compartment. Forms SNARE complexes with the t-SNAREs TLG1 and TLG2, and either the v-SNARE SNC1 or SNC2, which are involved in traffic from early endosomes to the trans-Golgi network (TGN). Forms SNARE complexes with the t-SNAREs PEP12 and either SYN8 or TLG1, and the v-SNARE SNC1, which are involved in traffic from the TGN to the prevacuolar compartment (PVC).
messages: Golgi apparatus membrane
messages: Prevacuolar compartment membrane
messages: t-SNARE found in various SNARE complexes involved in multiple transport pathways. The composition of the t-SNARE complexes is specific for a limited number of v-SNAREs and therefore allows only the vesicles carrying the matching v-SNARE to fuse.

559292:YPL122C
gene id: 559292:YPL122C
uniprot id: Q02939
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB2 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription (PubMed:7961739, PubMed:14500720, PubMed:9235928). Interacts with TFB5 (PubMed:19172752).
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus
messages: Present with 8900 molecules/cell in log phase SD medium.

559292:YEL030W
gene id: 559292:YEL030W
uniprot id: P39987
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Plays a role in facilitating the assembly of some protein complexes inside the mitochondria. It may initiate the events that lead to refolding of imported precursors in the matrix space.
messages: mitochondrion nucleoid

559292:YPL119C-A
gene id: 559292:YPL119C-A
uniprot id: Q3E751
names: Subcellular Location Annotation
messages: Membrane

559292:YNL180C
gene id: 559292:YNL180C
uniprot id: P53879
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Interacts with RGD2.
messages: Leads to resistance to oxidants such as H(2)O(2) (PubMed:25598154). Impairs apoptotic phenotype after H(2)O(2) treatment (PubMed:25598154). Leads to hyper-resistance to cell wall stress agents such as calcofluor white and Congo red (PubMed:25598154).
messages: Membrane
messages: Mitochondrion
messages: Present with 2180 molecules/cell in log phase SD medium.
messages: Small GTPase that negatively regulates a MAP kinase branch, downstream of SLT2, of the PKC1-mediated signal transduction pathway (PubMed:12118069). With its specific guanine nucleotide exchange factor (GEF), the heterodimeric complex DCK1/LMO1, relocates to mitochondria upon oxidative stress and triggers cell death (PubMed:25598154). The DCK1/LMO1/RHO5 signaling module that mediates mitochondrial turnover under nitrogen starvation conditions via mitophagy (PubMed:25598154). The DCK1/LMO1/RHO5 signaling module also plays a role in cell wall integrity signaling (PubMed:25598154).

559292:YHR144C
gene id: 559292:YHR144C
uniprot id: P06773
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
messages: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Catalyzes the hydrolytic deamination of dCMP to yield dUMP, the nucleotide substrate for thymidylate synthetase.
messages: Present with 1510 molecules/cell in log phase SD medium.

559292:YDR497C
gene id: 559292:YDR497C
uniprot id: P30605
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Major transporter for myo-inositol.

559292:YPR194C
gene id: 559292:YPR194C
uniprot id: Q06593
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane
messages: Transports tetra- and pentapeptides. Does not transport glutathione.

559292:YGL067W
gene id: 559292:YGL067W
uniprot id: P53164
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Homodimer.
messages: Peroxisome
messages: Present with 846 molecules/cell in log phase SD medium.
messages: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives (PubMed:11361135).

559292:YBR268W
gene id: 559292:YBR268W
uniprot id: P36532
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543). mL54 may have a meiosis-specific role as it accumulates during the middle stage of sporulation (PubMed:15543521).
messages: Mitochondrion
messages: Present with 1100 molecules/cell in log phase SD medium.

559292:YMR239C
gene id: 559292:YMR239C
uniprot id: Q02555
names: Function
names: Miscellaneous
messages: DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing.
messages: Present with 4970 molecules/cell in log phase SD medium.

559292:YKR048C
gene id: 559292:YKR048C
uniprot id: P25293
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acidic protein, which assembles histones into an octamer (in vitro). Involved in the regulation of the localization and the function of the septins during mitosis. Involved in the function of B-type cyclins.
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: Bud neck
messages: Component of the GIN4 complex composed of at least BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1 which forms a ring at the bud neck (PubMed:12058072). Homodimer (in-vitro) (PubMed:16432217). Interacts with the B-type cyclin CLB2 (PubMed:7622566). Interacts with 60S ribosomal protein L18 (RPL18A or RPL18B), CKA2, CKI1, eukaryotic elongation factor 1 complex eEF1A (TEF1 or TEF2), FOL1, HSC82, HTA2, HTB2, HTZ1, KAP114, KCC4, NIS1, SSA1, SSA2, SSB1, SSC1, SHM1, SIP5 and TCO89 (PubMed:18086883). Interacts with NBA1 (PubMed:18086883). Interacts with histone H3/H4 heterodimers (PubMed:27036862).
messages: Cytoplasm
messages: Exhibits a large proportion of multinucleate cells. Elongated buds. The percentage of elongated buds is significantly increased when GIN4 or CKI1 is also deleted. Small decrease in the percentage of cells with elongated buds is observed in NAP1 and CKA2 double mutant. NAP1 and CKI1 double mutant exhibits increased sensitivity to benomyl. Increased resistance to benomyl in NAP1 and CKA2 double mutant.
messages: NAP-I was previously referred to as AP-I.
messages: Nucleus
messages: Phosphorylation by CK2 is required for normal progression through S phase. CK2 phosphorylation is not required for correct bud formation nor histone binding.
messages: Present with 8070 molecules/cell in log phase SD medium.
messages: The acidic domains are probably involved in the interaction with histones.

559292:YGR287C
gene id: 559292:YGR287C
uniprot id: P53051
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Expression is increased in response to the addition of maltose, isomaltose, and alpha-methylglucopyranoside.
messages: Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization. Preferentially hydrolyzes isomaltose, palatinose, and methyl-alpha-glucoside, with little activity towards isomaltotriose or longer oligosaccharides. Does not hydrolyze maltose.
messages: Mitochondrion
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YER076C
gene id: 559292:YER076C
uniprot id: P40049
names: Similarity
messages: To yeast killer toxin KHR.

559292:YDL048C
gene id: 559292:YDL048C
uniprot id: Q07351
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus
messages: Present with 623 molecules/cell in log phase SD medium.

559292:YHR090C
gene id: 559292:YHR090C
uniprot id: P38806
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

559292:YPL183W-A
gene id: 559292:YPL183W-A
uniprot id: O14464
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL36 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. bL36m has a zinc binding site.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:24675956). bL36m may be involved in a process influencing telomere capping (PubMed:18845848, PubMed:20691087).
messages: Mitochondrion
messages: Present with 500 molecules/cell in log phase SD medium.

559292:YDR264C
gene id: 559292:YDR264C
uniprot id: P39010
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Palmitoyltransferase specific for casein kinase 1. Palmitoylates isoforms YCK1 and YCK2 at both C-terminal cysteine residues, which is required for their proper plasma membrane localization. Required for constitutive endocytosis of a-factor receptor STE3 and both constitutive and pheromone-induced endocytosis of alpha-factor receptor STE2.
messages: Present with 4072 molecules/cell in log phase SD medium.
messages: The DHHC domain is required for palmitoyltransferase activity.

559292:YAL035W
gene id: 559292:YAL035W
uniprot id: P39730
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Binds 1 monovalent cation per monomer in the active site, which can be sodium or potassium. This structural cofactor stabilizes the GTP-bound 'on' state, and may also act as a transition state stabilizer of the hydrolysis reaction.
messages: Cytoplasm
messages: Plays a role in translation initiation (PubMed:9624054). Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:12507428, PubMed:12471154, PubMed:12008673). GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome (PubMed:25478828). The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes (PubMed:12507428, PubMed:18976658, PubMed:19029250). Stimulates 20S pre-rRNA cleavage to mature 18S rRNA by PIN-domain endonuclease NOB1 (PubMed:22751017).
messages: Present with 13400 molecules/cell in log phase SD medium.

559292:YKL180W
gene id: 559292:YKL180W
uniprot id: P05740
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL22 is associated with the polypeptide exit tunnel (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: There are 2 genes for uL22 in yeast.

559292:YAL043C
gene id: 559292:YAL043C
uniprot id: Q01329
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.
messages: Essential in pre-tRNA processing. Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.
messages: Nucleus
messages: Present with 3730 molecules/cell in log phase SD medium.

559292:YMR043W
gene id: 559292:YMR043W
uniprot id: P11746
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Binds DNA with a high specificity in complex with mating-type protein ALPHA1. Also binds DNA with a high specificity as a heterotetramer consisting of an ALPHA2 dimer and an MCM1 dimer. Interacts with YHP1 and YOX1, possibly leading to its inactivation. Interacts with ARG80 and ARG82.
messages: Nucleus
messages: Present with 8970 molecules/cell in log phase SD medium.
messages: Transcription factor required for the efficient replication of minichromosomes and the transcriptional regulation of early cell cycle genes. Activates transcription of ECB-dependent genes during the G1/M phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Interacts with the alpha-2 repressor or with the alpha-1 activator thereby regulating the expression of mating-type-specific genes. With ARG80, ARG81 and ARG82, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.

559292:YCL061C
gene id: 559292:YCL061C
uniprot id: P25588
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CDC45 in S phase.
messages: Nucleus
messages: Phosphorylated by MEC1 and RAD53.
messages: Present with 721 molecules/cell in log phase SD medium.
messages: Required for normal DNA replication. Phosphorylated in response to DNA replication stress. Phosphorylation allows it to mediate the activation of RAD53.

559292:YPL099C
gene id: 559292:YPL099C
uniprot id: Q02888
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INA17 family.
messages: Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain.
messages: Component of the inner membrane assembly (INA) complex, composed of INA17 and INA22. Interacts with a subset of F(1)F(0)-ATP synthase subunits of the F(1)-domain and the peripheral stalk.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion inner membrane

559292:YHR087W
gene id: 559292:YHR087W
uniprot id: P38804
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDO1-like family.
messages: Cytoplasm
messages: May play a role in RNA metabolism, rRNA-processing, and in a process influencing telomere capping.
messages: Nucleus
messages: Present with 2430 molecules/cell in log phase SD medium.

559292:YPR066W
gene id: 559292:YPR066W
uniprot id: Q99344
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric UBA3-ULA1 E1 enzyme. E1 activates NEDD8/RUB1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBC12.
messages: Heterodimer of UBA3 and ULA1. Interacts with NEDD8 and UBC12 (By similarity).
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YLR429W
gene id: 559292:YLR429W
uniprot id: Q06440
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds to F-actin.
messages: Present with 2900 molecules/cell in log phase SD medium.

559292:YIR035C
gene id: 559292:YIR035C
uniprot id: P40579
names: Miscellaneous
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Present with 2370 molecules/cell in log phase SD medium.

559292:YDR144C
gene id: 559292:YDR144C
uniprot id: P53379
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Cell membrane
messages: Cleaves proteins C-terminally to the most C-terminal basic residue. Can process the alpha-mating factor precursor. Required for cell wall integrity.
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YLL067C
gene id: 559292:YLL067C
uniprot id: Q07888
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YOL119C
gene id: 559292:YOL119C
uniprot id: Q08268
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane
messages: Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane.

559292:YJL164C
gene id: 559292:YJL164C
uniprot id: P06244
names: Activity Regulation
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Activated by cAMP.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Present with 4320 molecules/cell in log phase SD medium.

559292:YLR209C
gene id: 559292:YLR209C
uniprot id: Q05788
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Present with 1630 molecules/cell in log phase SD medium.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).

559292:YGR111W
gene id: 559292:YGR111W
uniprot id: P53265
names: Miscellaneous
messages: Present with 768 molecules/cell in log phase SD medium.

559292:YBR065C
gene id: 559292:YBR065C
uniprot id: P38241
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome subcomplex composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with SLU7.
messages: Belongs to the SLT11 family.
messages: Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.
messages: Nucleus
messages: Present with 4260 molecules/cell in log phase SD medium.

559292:YFL010C
gene id: 559292:YFL010C
uniprot id: P43582
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with metacaspase MCA1.
messages: Involved in apoptosis. May play a role in nuclear function controlling cellular proliferation coupled to mitochondrial biogenesis. Causes impaired growth when overexpressed.
messages: Mitochondrion
messages: Nucleus
messages: Present with 6020 molecules/cell in log phase SD medium.

559292:YPL156C
gene id: 559292:YPL156C
uniprot id: Q12498
names: Subcellular Location Annotation
messages: Membrane

559292:YIL122W
gene id: 559292:YIL122W
uniprot id: P40473
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POG1 family.
messages: Expressed periodically during cell division. Regulated by the SBF complex which is one critical regulator of the start of the cell cycle.
messages: Nucleus
messages: Phosphorylated by CDC28.
messages: Present with 736 molecules/cell in log phase SD medium.
messages: Transcriptional activator which promotes cell cycle recovery with CLN2, after pheromone induced G1 arrest, probably inhibiting the ability of STE20 to activate the pheromone response pathway. Binds the promoters of genes that function in cell cycle regulation, cytoskeletal organization, and spindle assembly. May also be involved in stress-resistance.

559292:YIR025W
gene id: 559292:YIR025W
uniprot id: P40577
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC15 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1. MND2 interacts directly with APC1, APC5 and CDC23.

559292:YGL211W
gene id: 559292:YGL211W
uniprot id: P53088
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Interacts with NCS2 and URM1. May act by forming a heterodimer with NCS2. Component of a large molecular weight complex of more than 250 kDa.
messages: Mitochondrion
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. May also be involved in protein urmylation and in invasive and pseudohyphal growth.

559292:YBR047W
gene id: 559292:YBR047W
uniprot id: P38231
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: In aerobic conditions. Expression is regulated by copper levels and the MAC1 copper-responsive transcription factor.
messages: May be involved in mitochondrial iron or copper homeostatis.
messages: Mitochondrion
messages: Present with 2160 molecules/cell in log phase SD medium.

559292:YNL219C
gene id: 559292:YNL219C
uniprot id: P53868
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides.
messages: Endoplasmic reticulum membrane

559292:YPL055C
gene id: 559292:YPL055C
uniprot id: Q02796
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Present with 2060 molecules/cell in log phase SD medium.
messages: Probably interacts with BRE1.
messages: Required to activate transcription of PDR3, a gene involved in retrograde regulation of multidrug resistance, a phenomenon that takes place in cells that have lost their mitochondrial genome. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear and is independent of retrograde regulation of multidrug resistance function.

559292:YOL143C
gene id: 559292:YOL143C
uniprot id: P50861
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Homopentamer.
messages: Is constitutively expressed at moderate levels.
messages: Mitochondrion intermembrane space
messages: Present with 3260 molecules/cell in log phase SD medium.

559292:YGR230W
gene id: 559292:YGR230W
uniprot id: P50084
names: Function
messages: Component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase and is required for the efficient segregation of telomeric and nucleolar regions. Although BNS1 can partially compensate for a lack of SPO12 function when overexpressed, it does not appear to play any role in controlling meiotic nuclear division.

559292:YFL062W
gene id: 559292:YFL062W
uniprot id: P43542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Membrane

559292:YAL012W
gene id: 559292:YAL012W
uniprot id: P31373
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the production of cysteine from cystathionine in the reverse transsulfuration pathway for the biosynthesis of sulfur-containing amino acids cysteine and methionine. In this pathway, homocysteine sulfur is converted to cysteine sulfur (Probable). Also has cystathionine beta-lyase and cystathionine gamma-synthase activities in vitro. Cystathionine beta-lyase may be physiological, while cystathionine gamma-synthase activity is not, as the required substrate O-succinyl-L-homoserine(OSH) does not occur naturally in S.cerevisiae (PubMed:8335636).
messages: Cytoplasm
messages: Homotetramer.
messages: Present with 38300 molecules/cell in log phase SD medium.

559292:YPL009C
gene id: 559292:YPL009C
uniprot id: Q12532
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the ribosome quality control complex (RQC), a ribosome-associated complex, mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation. Thereby, frees ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:23178123). RQC2 is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety (PubMed:25349383). RQC2 is important for the stable association of the E3 ubiquitin-protein ligase RKR1/LTN1 to the complex (PubMed:23479637). RQC2 is also able to recruit alanine- and threonine-charged tRNA to the A site and directs the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails) (PubMed:25554787, PubMed:32934225). CAT tails induce a HSF1-dependent heat shock response (PubMed:25554787). CAT tails also promote the RKR1/LTN1-mediated ubiquitination of incompletely synthesized nascent polypeptides and their subsequent proteasomal degradation (PubMed:32934225).
messages: Belongs to the NEMF family.
messages: Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase RKR1/LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors associated with the 60S ribosomal subunit (PubMed:23178123, PubMed:23479637, PubMed:25349383). RQC2 binds to the 40S-binding surface of tRNAs (PubMed:25554787).
messages: Cytoplasm
messages: Present with 7700 molecules/cell in log phase SD medium.

559292:YNL005C
gene id: 559292:YNL005C
uniprot id: P12687
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL27 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 2300 molecules/cell in log phase SD medium.

559292:YOL129W
gene id: 559292:YOL129W
uniprot id: Q12016
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Involved in vacuolar protein sorting.
messages: Mitochondrion
messages: Present with 1900 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YPR164W
gene id: 559292:YPR164W
uniprot id: Q06211
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of multiple cullin-RING ligases (CRLs) composed of 4 subunits: the RING protein HRT1, the cullin RTT101, a linker protein MMS1, and one of many alternative substrate receptors belonging to a protein family described as DCAF (DDB1- and CUL4-associated factor). Component of a RTT101(MMS1-MMS22) complex with the substrate receptor MMS22. This complex further interacts with RTT107 and CTF4 to form RTT101-MMS1-MMS22-RTT107 and RTT101-MMS1-MMS22-CTF4 complexes respectively. Component of a RTT101(MSS1-CRT10) complex with the substrate receptor CRT10. Component of a RTT101(MSS1-ESC2) complex with the potential substrate receptor ESC2. Component of a RTT101(MSS1-ORC5) complex with the potential substrate receptor ORC5. Interacts with RTT101 (via N-ter). Interacts (via N-ter) with MMS22 (via C-ter). Interacts with CRT10.
messages: Component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Involved in the regulation of TY1 transposition.
messages: Nucleus

559292:YBL037W
gene id: 559292:YBL037W
uniprot id: P38065
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adaptor. Facilitates interaction between APL1 and APS2.
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).
messages: Belongs to the adaptor complexes large subunit family.
messages: Cell membrane
messages: Present with 1590 molecules/cell in log phase SD medium.
messages: coated pit

559292:YOR292C
gene id: 559292:YOR292C
uniprot id: Q08743
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: N-glycosylated.
messages: Vacuole membrane

559292:YDL021W
gene id: 559292:YDL021W
uniprot id: Q12008
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Could be non-functional.
messages: Cytoplasm
messages: Present with 2020 molecules/cell in log phase SD medium.
messages: Sensitive to sodium dodecyl sulfate.

559292:YLR405W
gene id: 559292:YLR405W
uniprot id: Q06063
names: Function
names: Similarity
messages: Belongs to the Dus family. Dus4 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:14970222). Specifically modifies U20a and U20b in cytoplasmic tRNAs (PubMed:14970222). Also able to mediate dihydrouridylation of some mRNAs, thereby affecting their translation (By similarity).

559292:YPL056C
gene id: 559292:YPL056C
uniprot id: Q02786
names: Disruption Phenotype
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Deletion leads to fluconazole resistance.
messages: Leads to long chronological lifespan.

559292:YKR044W
gene id: 559292:YKR044W
uniprot id: P36137
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus membrane
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YER167W
gene id: 559292:YER167W
uniprot id: P33306
names: Function
messages: Dosage dependent suppressor of PKC1 deletion and MPK1 deletion. Involved in cell lysis.

559292:YOR387C
gene id: 559292:YOR387C
uniprot id: Q08910
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VEL1 family.
messages: By zinc depletion.
messages: N-glycosylated.
messages: cytosol

559292:YBR263W
gene id: 559292:YBR263W
uniprot id: P37292
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Homotetramer (By similarity). Interacts with NAP1.
messages: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
messages: Interconversion of serine and glycine.
messages: Mitochondrion
messages: Present with 17700 molecules/cell in log phase SD medium.

559292:YKR004C
gene id: 559292:YKR004C
uniprot id: Q02202
names: Function
names: Miscellaneous
messages: May be involved in cell wall organization and biogenesis.
messages: Present with 846 molecules/cell in log phase SD medium.

559292:YKR051W
gene id: 559292:YKR051W
uniprot id: P36142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM184 family.
messages: Membrane

559292:YGL180W
gene id: 559292:YGL180W
uniprot id: P53104
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by hypophosphorylated form of ATG13 (present in nitrogen starvation conditions). Also activated by autophopsphorylation of Thr-226 and inhibited by phosphorylation of Ser-34.
messages: Autophosphorylated at Thr-226 and Ser-390. The phosphorylation state may play a role in the induction of protein degradation upon starvation. Phosphorylation at Thr-226 within the activation loop is required for protein kinase activity whereas phosphorylation at Ser-34 leads to inhibition of kinase activity. Phosphorylation of Ser-508 and Ser-515 by PKA is required to induce autophagy but not for kinase activity.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Cytoplasm
messages: Homodimer. Dimerization requires the presence of ATG13. Forms a ternary complex with ATG13 and ATG17. Interacts also with ATG11.
messages: Preautophagosomal structure membrane
messages: Present with 1070 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:18818209, PubMed:21576396, PubMed:22768199, PubMed:23230142). Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates (PubMed:21228276). Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9 (PubMed:14723849, PubMed:20855505, PubMed:24905091, PubMed:24440502). Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (PubMed:28821724). Finally, ATG1 is also required for the maintenance of cell viability under starvation and for glycogen storage during stationary phase. Plays a role in genome stability through suppression of abnormal mitosis under starvation, and in regulation of filamentous growth.
messages: The LIR motif is required for the interaction with ATG8 and for the association of ATG1 with autophagosomes.

559292:YDR428C
gene id: 559292:YDR428C
uniprot id: Q04066
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Cells exhibit slow growth in the absence of nicotinate.
messages: Homodimer.
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

559292:YML036W
gene id: 559292:YML036W
uniprot id: Q03705
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CGI121/TPRKB family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.
messages: Nucleus
messages: telomere

559292:YLR038C
gene id: 559292:YLR038C
uniprot id: Q01519
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6B family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: Present with 1390 molecules/cell in log phase SD medium.
messages: The Cx9C/Cx10C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.

559292:YJR066W
gene id: 559292:YJR066W
uniprot id: P35169
names: Activity Regulation
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the glutamine sensor PIB2 in nutrient-rich conditions.
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Increases cellular levels of glutamine and alanine during high hydrostatic pressure (mechanical stress) (PubMed:32801125). Sensitive to high hydrostatic pressure (mechanical stress) (PubMed:32801125).
messages: It is uncertain whether Met-1 is the initiator.
messages: It may act on another substrate or phosphorylate a different position in the phosphatidylinositol ring.
messages: Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4 (PubMed:10198052, PubMed:10329624, PubMed:10604478, PubMed:10995454, PubMed:11741537, PubMed:15620355, PubMed:7606777, PubMed:8741837, PubMed:9539725, PubMed:9843498, PubMed:28993463). In nutrient-rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) YPK3, activating YPK3 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:25767889). Phosphorylates kinase SCH9 at 6 amino acids in the C-terminus, activating SCH9 kinase activity to properly regulate ribosome biogenesis, translation initiation, and entry into stationary phase (PubMed:17560372).
messages: Present with 589 molecules/cell in log phase SD medium.
messages: The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B) (PubMed:12408816, PubMed:12631735). Interacts with PIB2; following activation of PIB2 by glutamine or cysteine (PubMed:34535752, PubMed:29698392, PubMed:28483912). TORC1 binds to and is inhibited by FKBP-rapamycin (PubMed:12408816, PubMed:7606777).
messages: Vacuole membrane

559292:YLR016C
gene id: 559292:YLR016C
uniprot id: Q07930
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3 and PML1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1470 molecules/cell in log phase SD medium.
messages: Required for efficient splicing and pre-mRNA nuclear retention.

559292:YKL178C
gene id: 559292:YKL178C
uniprot id: P06783
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 4 family.
messages: Membrane
messages: Receptor for the peptide pheromone a factor.

559292:YGL049C
gene id: 559292:YGL049C
uniprot id: P39936
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4G family.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A (TIF1/TIF2), eIF4E (TIF45) and eIF4G (TIF4631 or TIF4632) (By similarity). Interacts with PAT1 in a RNA-dependent manner.
messages: Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus. Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. TIF4632 is probably essential when TIF4631 is missing.
messages: Cytoplasm
messages: Present with 3390 molecules/cell in log phase SD medium.

559292:YKL125W
gene id: 559292:YKL125W
uniprot id: P36070
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRN3 family.
messages: Monomer (Probable). Interacts with NOP53.
messages: Nucleus
messages: Present with 138 molecules/cell in log phase SD medium.
messages: Required for efficient transcription initiation by RNA polymerase I. Interacts with Pol I in the absence of template DNA and stimulates recruitment of Pol I, but does not remain as part of stable preinitiation complex.

559292:YJL090C
gene id: 559292:YJL090C
uniprot id: P47027
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint. Required for the association of PSF1 with origins. Also required for the proper activation of RAD53 in response to DNA damage and replication blocks. Multicopy suppressor of DPB2 mutation. Overexpression restores the growth defect conferred by POL2 mutation.
messages: Interacts with SLD2.
messages: Nucleus
messages: Present with 540 molecules/cell in log phase SD medium.

559292:YIL128W
gene id: 559292:YIL128W
uniprot id: P40469
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) machinery that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. Acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as RAD3/XPD and DNA2, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription.
messages: Nucleus
messages: Present with 3150 molecules/cell in log phase SD medium.

559292:YBR106W
gene id: 559292:YBR106W
uniprot id: P38264
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PHO88 family.
messages: Endoplasmic reticulum membrane
messages: Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum. SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs (PubMed:27905431). Involved in inorganic phosphate uptake (PubMed:8709965). Also involved in telomere length regulation and maintenance (PubMed:16552446).
messages: Interacts with ENV10/SND2. ENV10/SND2 and PHO88/SND3 form a complex with the translocon in the endoplasmic reticulum membrane.
messages: Mitochondrion
messages: Present with 61800 molecules/cell in log phase SD medium.

559292:YER073W
gene id: 559292:YER073W
uniprot id: P40047
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose.
messages: Mitochondrion matrix
messages: Present with 23300 molecules/cell in log phase SD medium.
messages: The activity increases in the presence of K(+) ions: 15-fold with NADP and 40-fold with NAD, respectively.

559292:YBR001C
gene id: 559292:YBR001C
uniprot id: P35172
names: Miscellaneous
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.
messages: Present with 2500 molecules/cell in log phase SD medium.

559292:YDR028C
gene id: 559292:YDR028C
uniprot id: Q00816
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SAK1.
messages: Involved in RNA processing and negative regulation of glucose repression. Regulates the level of two antigens, P43 and P70. Binds to protein phosphatase type 1. Functions with REG2 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly.
messages: Nucleus
messages: Present with 2560 molecules/cell in log phase SD medium.

559292:YPR079W
gene id: 559292:YPR079W
uniprot id: Q06815
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRL1/IGF2R family.
messages: Endosome membrane
messages: Sorting receptor involved in the transport of vacuolar enzymes from the Golgi complex to the vacuole. Involved in the delivery and maturation of PEP4 (vacuolar proteinase A) and PRB1 (vacuolar proteinase B).
messages: trans-Golgi network membrane

559292:YMR097C
gene id: 559292:YMR097C
uniprot id: Q03151
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrial GTPase involved in assembly of the large ribosomal subunit (PubMed:12808030). Plays a role in expression of the mitochondrial translational machinery (PubMed:12808030).
messages: Mitochondrion inner membrane
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YCR010C
gene id: 559292:YCR010C
uniprot id: P25613
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Cell membrane
messages: During meiosis and by external ammonia.
messages: Transporter protein required for ammonia export and acetate uptake and resistance. Necessary for up-regulation and down-regulation of meiotic plaque (MP) component levels in a dependency on external acetate. Has a role in ascus formation.
messages: Vacuole membrane

559292:YDR182W-A
gene id: 559292:YDR182W-A
uniprot id: Q3E796
names: Subcellular Location Annotation
messages: Membrane

559292:YER080W
gene id: 559292:YER080W
uniprot id: P40053
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM9 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion
messages: Present with 8200 molecules/cell in log phase SD medium.

559292:YGR210C
gene id: 559292:YGR210C
uniprot id: P42942
names: Miscellaneous
messages: Present with 11600 molecules/cell in log phase SD medium.

559292:YOR342C
gene id: 559292:YOR342C
uniprot id: Q12182
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YJL176C
gene id: 559292:YJL176C
uniprot id: P32591
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with RTT102, SWP82 and the N-terminus of SNF2. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Nucleus
messages: Present with 3150 molecules/cell in log phase SD medium.

559292:YDR236C
gene id: 559292:YDR236C
uniprot id: Q03778
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
messages: Endoplasmic reticulum
messages: FMN1 is essential for growth on rich medium.
messages: Microsome
messages: Mitochondrion inner membrane
messages: Present with 830 molecules/cell in log phase SD medium.
messages: The subcellular location of this enzyme needs further confirmation.
messages: Zinc or magnesium.

559292:YGL123W
gene id: 559292:YGL123W
uniprot id: P25443
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS5 is important for the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: nucleolus

559292:YNL118C
gene id: 559292:YNL118C
uniprot id: P53550
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.
messages: Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:10508173, PubMed:11139489, PubMed:11741542). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12554866). Decapping is the major pathway of mRNA degradation in yeast and occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (PubMed:10508173, PubMed:11139489, PubMed:11741542). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:19779198).
messages: Component of the decapping complex composed of DCP1 and DCP2 (PubMed:10508173, PubMed:11741542, PubMed:14758354). Interacts with mRNA, LSM2, LSM4 and LSM8 (PubMed:10900456). Interacts with EDC3 (PubMed:18678652).
messages: Increases autophagy activity through accumulation of autophagy-related proteins in nutrient-replete conditions (PubMed:19779198).
messages: P-body
messages: Present with 8530 molecules/cell in log phase SD medium.

559292:YGR150C
gene id: 559292:YGR150C
uniprot id: P48237
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCM1 family.
messages: Mitochondrion
messages: Present with 876 molecules/cell in log phase SD medium.
messages: RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome.

559292:YOR079C
gene id: 559292:YOR079C
uniprot id: Q12067
names: Function
names: Subcellular Location Annotation
messages: Functions in the homeostasis of manganese ions.
messages: Golgi apparatus membrane

559292:YPL181W
gene id: 559292:YPL181W
uniprot id: Q08923
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Interacts with CYC8.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor. Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters.
messages: Nucleus
messages: Present with 1590 molecules/cell in log phase SD medium.
messages: Under low iron conditions.

559292:YOR312C
gene id: 559292:YOR312C
uniprot id: P0CX23
uniprot id: P0CX24
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eL20 forms multiple interactions with RNA and proteins in the central protuberance, connecting components of core functional centers that are locatzed far apart (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 54300 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL20 in yeast.

559292:YJL065C
gene id: 559292:YJL065C
uniprot id: P40366
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ISW2 complex, which at least consists of ISW2, ITC1, DLS1 and DPB4.
messages: Functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. DLS1 is partially required for the ISW2 complex chromatin remodeling activity and is not required for its interaction with chromatin.
messages: Nucleus
messages: Present with 3390 molecules/cell in log phase SD medium.

559292:YER111C
gene id: 559292:YER111C
uniprot id: P25302
names: Function
names: Miscellaneous
names: Subunit
messages: Component of the transcription complex SCB-binding factor (SBF) composed of SWI6 and SWI4. Interacts with MSA2.
messages: Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YPL152W
gene id: 559292:YPL152W
uniprot id: Q12461
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the phosphatase PP2A catalytic subunits PPH21 and PPH22. Forms a ternary complex with PPH21-TAP42.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Acts also inhibitory at high concentrations. Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis.
messages: Present with 2430 molecules/cell in log phase SD medium.

559292:YNL284C
gene id: 559292:YNL284C
uniprot id: P36520
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 5350 molecules/cell in log phase SD medium.

559292:YNL054W-A
gene id: 559292:YNL054W-A
uniprot id: Q12470
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-NL2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YLR227W-A
gene id: 559292:YLR227W-A
uniprot id: P0CX74
uniprot id: P0CX75
uniprot id: P0CX76
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-JR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR3 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ML2 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YGL064C
gene id: 559292:YGL064C
uniprot id: P53166
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA.
messages: Belongs to the DEAD box helicase family. MRH4 subfamily.
messages: Mitochondrion
messages: Present with 736 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

559292:YHR122W
gene id: 559292:YHR122W
uniprot id: P38829
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the MIP18 family.
messages: May play a role in chromosome segregation through establishment of sister chromatid cohesion.
messages: Present with 1800 molecules/cell in log phase SD medium.

559292:YMR188C
gene id: 559292:YMR188C
uniprot id: Q03246
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). uS17m may have a meiosis-specific role as it accumulates during the middle stage of sporulation (PubMed:15543521).
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 2810 molecules/cell in log phase SD medium.

559292:YDL173W
gene id: 559292:YDL173W
uniprot id: Q12515
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hyperphosphorylated after treatment with rapamycin in a TAP42-dependent manner.
messages: Involved in resistance to cisplatin.
messages: Present with 1140 molecules/cell in log phase SD medium.

559292:YKL182W
gene id: 559292:YKL182W
uniprot id: P07149
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the fungal fatty acid synthetase subunit beta family.
messages: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
messages: Present with 91800 molecules/cell in log phase SD medium.
messages: [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).

559292:YKR045C
gene id: 559292:YKR045C
uniprot id: P36138
names: Subcellular Location Annotation
messages: Cytoplasm

559292:YER045C
gene id: 559292:YER045C
uniprot id: P39970
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: By nitrogen limitation.
messages: Nucleus
messages: This ORF was incorrectly assigned as MEI4.
messages: Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources. Regulates the expression of COS8. Has efficient silencing blocking activities.

559292:YGL160W
gene id: 559292:YGL160W
uniprot id: P53109
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferric reductase (FRE) family. AIM14 subfamily.
messages: Increases frequency of mitochondrial genome loss.
messages: Interacts with ribosomes.
messages: Membrane
messages: Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity).

559292:YOR239W
gene id: 559292:YOR239W
uniprot id: Q08641
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. METL family.
messages: Cytoplasm
messages: Interacts with SES1.
messages: N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift (PubMed:9467951). ABP140 mRNA translation follows a cotranslational transport: mRNA is transported to the distal pole of the mother cell, independently of the SHE machinery, and follows a translational coupling, in which ABP140 mRNA is tethered to actin cables via its nascent protein product and is transported to the distal pole by actin retrograde flow (PubMed:21792172).
messages: Produced by ribosomal frameshifting between codon Leu-277 and Gly-278.
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr) and tRNA(Ser) (PubMed:21518804, PubMed:21518805, PubMed:28003514). N(3)-methylcytidine methylation of tRNA(Thr) requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:28003514). N(3)-methylcytidine methylation of tRNA(Ser) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by MOD5 as prerequisite (PubMed:28003514). Methylation of tRNA(Ser) is also stimulated by SES1 (PubMed:28003514). Binds F-actin and shows weak F-actin cross-linking activity (PubMed:9467951).
messages: cytoskeleton

559292:YHR135C
gene id: 559292:YHR135C
uniprot id: P23291
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
messages: Cell membrane
messages: Mitochondrion membrane
messages: Palmitoylated by AKR1.
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YNL201C
gene id: 559292:YNL201C
uniprot id: P40164
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.
messages: Nucleus
messages: Present with 7010 molecules/cell in log phase SD medium.
messages: Regulatory subunit 3 (R3) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4. Interacts with SPT4, SPT5 and TIP41.

559292:YCL005W-A
gene id: 559292:YCL005W-A
uniprot id: Q3E7B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:14594803). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:14594803).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

559292:YHR097C
gene id: 559292:YHR097C
uniprot id: P38809
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pal1 family.
messages: Cytoplasm
messages: Nucleus

559292:YHR177W
gene id: 559292:YHR177W
uniprot id: P38867
names: Caution
messages: It is uncertain whether Met-1 or Met-2 is the initiator.

559292:YOL081W
gene id: 559292:YOL081W
uniprot id: P19158
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase activity of Ras proteins.

559292:YER067W
gene id: 559292:YER067W
uniprot id: P40043
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RGI1 family.
messages: Cell membrane
messages: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
messages: Present with 8450 molecules/cell in log phase SD medium.
messages: Up-regulated by a wide range of conditions, such as intracellular iron depletion, carbon source restriction, high temperature, high osmotic stress, cold stress, unfolded protein response, and high hydrostatic pressure. The promoter contains several binding sites for the stress response transcription factors MSN2, MSN4 and HSF1. Down-regulated when treated with different antifungal drugs from the azole class.

559292:YMR213W
gene id: 559292:YMR213W
uniprot id: Q03654
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEF1 family.
messages: Belongs to the NTC complex (or PRP19-associated complex), composed of at least CEF1, CLF1, ISY1, NTC20, SNT309, SYF1, SYF2, and PRP19. The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex (or CEF1-associated complex) reminiscent of a late-stage spliceosome composed also of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, LEA1, MSL1, PRP8, PRP9, PRP11, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNU114, SPP2, RSE1 and YJU2. Interacts with CLF1, ISY1, NTC20, PRP19, PRP46, SYF1 and SYF2.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing and cell cycle control. Required for the binding of the NTC complex (or PRP19-associated complex) components to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Its absence leads to an arrest of the cell cycle, possibly due to the inefficient splicing of TUB1.
messages: Nucleus
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YGR104C
gene id: 559292:YGR104C
uniprot id: P32585
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. SRB5/MED18 interacts directly with MED8 and SRB2/MED20.
messages: Nucleus
messages: Present with 1011 molecules/cell in log phase SD medium.

559292:YDR372C
gene id: 559292:YDR372C
uniprot id: Q06385
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Homotetramer. Interacts with coatomer complex. May interact with ARF1.
messages: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.
messages: Present with 1850 molecules/cell in log phase SD medium.

559292:YOL120C
gene id: 559292:YOL120C
uniprot id: P0CX49
uniprot id: P0CX50
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). eL18 interacts with NAP1 (PubMed:18086883).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 63700 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL18 in yeast.

559292:YCR012W
gene id: 559292:YCR012W
uniprot id: P00560
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.
messages: Present with 314000 molecules/cell in log phase SD medium.

559292:YLR094C
gene id: 559292:YLR094C
uniprot id: Q12418
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 1055 molecules/cell in log phase SD medium.

559292:YGR080W
gene id: 559292:YGR080W
uniprot id: P53250
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. Prevents actin filament assembly by forming a 1:1 complex with actin monomers, and inhibits the nucleotide exchange reaction of actin monomers (By similarity).
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Interacts with G-actin; ADP-actin form.
messages: Present with 1470 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YPR158C-D
gene id: 559292:YPR158C-D
uniprot id: P0C2J1
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YPR158C-C ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YPR131C
gene id: 559292:YPR131C
uniprot id: Q06504
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. GNAT subfamily.
messages: Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn, Met-Gln or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions, it is presumed to N-acetylate 15% of all yeast proteins.
messages: Component of the N-terminal acetyltransferase B (NatB) complex, which is composed of NAT3 and MDM20.
messages: Cytoplasm
messages: Present with 639 molecules/cell in log phase SD medium.

559292:YDL045C
gene id: 559292:YDL045C
uniprot id: P38913
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. FAD1 subfamily.
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: Cytoplasm
messages: FAD1 is essential for growth.

559292:YIL043C
gene id: 559292:YIL043C
uniprot id: P38626
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Competitively inhibited by NAD(+). Inhibited by mercurials such as p-chloromercuribenzoate (PCMB) and HgCl(2). Enzymatic activity increases under anaerobic conditions.
messages: Mitochondrion outer membrane
messages: Monomer (PubMed:14930). Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:27694803). Interacts with KTI11/DPH3 (PubMed:27694803). Interacts with STE20 (PubMed:17895367).
messages: NADH-dependent reductase for KTI11/DPH3 and cytochrome b5 (PubMed:14930, PubMed:10622712, PubMed:27694803, PubMed:31463593, PubMed:34154323). Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:31463593, PubMed:34154323, PubMed:27694803). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:31463593, PubMed:34154323). By reducing KTI11/DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex (PubMed:27694803). The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (PubMed:10622712). Plays a role in bud morphology (PubMed:17895367).
messages: Present with 4820 molecules/cell in log phase SD medium.
messages: Protein levels are highest during exponential growth phase and lowest in stationary phase.
messages: Simultaneous disruption of MCR1 results in resistance to diphtheria toxin and zymocin.

559292:YGR271W
gene id: 559292:YGR271W
uniprot id: P53327
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Component of the RQT (ribosome quality control trigger) complex, composed of SLH1, CUE3, and RQT4 (PubMed:28757607, PubMed:32203490). Interacts with CUE3 (PubMed:28757607). Interacts with RQT4 (PubMed:28757607). Interacts with HEL2 (PubMed:28757607, PubMed:28223409). Associates with translating ribosomes (PubMed:28757607).
messages: Defective activation of the ribosome quality control (RQC) pathway (PubMed:28757607, PubMed:28223409). Mildly defective ribosome stalling induced by RNA arrest sequences (PubMed:28223409). Sensitive to anisomycin (stalls ribosomes in the rotated state) (PubMed:28757607).
messages: Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:28223409, PubMed:32203490). Drives the splitting of stalled ribosomes that are polyubiquitinated in a HEL2-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32203490). Also represses the translation of non-poly(A) mRNAs together with SKI2 (PubMed:10922069). May block translation by inhibiting translation initiation factor 5B (FUN12) action on mRNAs lacking a 3' poly(A) structure (PubMed:11438647). Involved in antiviral defense, preventing L-A dsRNA virus propagation by specifically blocking translation of viral mRNAs (PubMed:10922069).
messages: Present with 486 molecules/cell in log phase SD medium.
messages: cytosol

559292:YLR420W
gene id: 559292:YLR420W
uniprot id: P20051
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: By N-carbamoyl-L-aspartate.
messages: Catalyzes the conversion of ureidosuccinic acid (USA) to dihydroorotate, the third step of the de novo pyrimidine biosynthetic pathway.
messages: Present with 12700 molecules/cell in log phase SD medium.

559292:YDR331W
gene id: 559292:YDR331W
uniprot id: P49018
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with CDC91, GPI16, GPI17 and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
messages: Present with 1560 molecules/cell in log phase SD medium.
messages: The disulfide bond between GPI8 and GPI16 is important for normal enzyme activity.

559292:YOL066C
gene id: 559292:YOL066C
uniprot id: Q12362
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.
messages: In the N-terminal section; belongs to the pseudouridine synthase RluA family.
messages: Involved in riboflavin biosynthesis. Converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate.
messages: Present with 1540 molecules/cell in log phase SD medium.
messages: Responsible for synthesis of pseudouridine from uracil-32 in cytoplasmic transfer RNAs.

559292:YER100W
gene id: 559292:YER100W
uniprot id: P33296
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.
messages: Endoplasmic reticulum membrane
messages: Present with 1900 molecules/cell in log phase SD medium.

559292:YCL052C
gene id: 559292:YCL052C
uniprot id: P25580
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: N-glycosylated.
messages: Present with 4930 molecules/cell in log phase SD medium.
messages: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Aids the autocatalytic processing of PRB1. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.

559292:YPL113C
gene id: 559292:YPL113C
uniprot id: Q02961
names: Function
names: Induction
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Glucose-repressed.
messages: Putative 2-hydroxyacid dehydrogenase.

559292:YER055C
gene id: 559292:YER055C
uniprot id: P00498
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).
messages: Cytoplasm

559292:YDR099W
gene id: 559292:YDR099W
uniprot id: P34730
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Interacts with NTH1 (via N-terminus when phosphorylated by PKA); the interaction is direct and activates NTH1 (PubMed:22320399). Interacts with FIN1 (PubMed:12551942).
messages: Nucleus
messages: Present with 47600 molecules/cell in log phase SD medium.

559292:YLR128W
gene id: 559292:YLR128W
uniprot id: Q12395
names: Function
names: Subunit
messages: Interacts with the cullin CDC53. Interacts with ubiquitin via its UBA-like domain. Interacts with RUB1/NEDD8.
messages: Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes.

559292:YBL026W
gene id: 559292:YBL026W
uniprot id: P38203
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. LSM2, probably in a complex that contains LSM2-LSM7 but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA. LSM2 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a doughnut shape. The LSm subunits are arranged in the order LSM1, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. Except for LSM1, where a C-terminal helix crosses the ring structure to form additional interactions with LSM3 and LSM6, each subunit interacts only with its two neighboring subunits. The LSM1-LSM7 complex interacts with PAT1; within the complex PAT1 has direct interactions with LSM2 and LSM3. Component of the heptameric LSM2-LSM8 complex that forms a seven-membered ring structure with a doughnut shape; an RNA strand can pass through the hole in the center of the ring structure. The LSm subunits are arranged in the order LSM8, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. LSM2-LSM8 associates with PAT1 and XRN1. A complex comprising LSM2-LSM7 without LSM1 or LSM8 may exist. Likewise, LSM2 and LSM3 can assemble into a doughnut structure that binds PAT1 (in vitro). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2210 molecules/cell in log phase SD medium.

559292:YGL041W-A
gene id: 559292:YGL041W-A
uniprot id: P0C5N3
names: Subcellular Location Annotation
messages: Mitochondrion

559292:YNL074C
gene id: 559292:YNL074C
uniprot id: P32047
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Disruption of the MLF3 gene causes increased sensitivity to the immunosuppressant leflunomide.
messages: To yeast VHS2.

559292:YBR250W
gene id: 559292:YBR250W
uniprot id: P33757
names: Disruption Phenotype
names: Function
names: Subunit
messages: Has a moderate sporulation defect.
messages: Interacts with SPO1 in meiosis.
messages: Regulates expression of PIS1.

559292:YGR183C
gene id: 559292:YGR183C
uniprot id: P22289
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). Interacts with the transmembrane segment of RIP1 (PubMed:30598556).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane
messages: Present with 4550 molecules/cell in log phase SD medium.

559292:YDL207W
gene id: 559292:YDL207W
uniprot id: Q12315
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLE1 family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. GLE1 interacts with the NUP82 subcomplex via NUP42. It also interacts with GFD1 and the ATP-dependent RNA helicase DBP5.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC probably by binding the ATP-dependent RNA helicase DBP5 and GFD1 at the cytoplasmic side of the NPC. These interactions are thought to be important for the dissociation of transport proteins such as the heterogeneous nuclear ribonucleoprotein (hnRNP) NAB2 from exported mRNA.
messages: Nucleus membrane
messages: Present with 1040 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YKR086W
gene id: 559292:YKR086W
uniprot id: P15938
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
messages: Influences the fidelity of branchpoint recognition in yeast splicing. This is RNA-dependent ATPase which is essential for viability. It may mediate one of the many ATP-requiring steps of spliceosome assembly and that accuracy of branchpoint recognition may be coupled to ATP binding and/or hydrolysis.
messages: Nucleus
messages: Present with 1250 molecules/cell in log phase SD medium.

559292:YBR111W-A
gene id: 559292:YBR111W-A
uniprot id: Q6WNK7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the mRNA export factors MEX67, MTR2 and SUB2, and the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11 and with the RNA polymerase II. Interacts with YRA1 and MEX67.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is involved in RNA polymerase II-dependent regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). Within the SAGA complex, participates in a subcomplex with SGF11, SGF73 and UBP8 required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. SUS1 has also a role in mRNP biogenesis and maintenance of genome integrity through preventing RNA-mediated genome instability. Has a role in response to DNA damage induced by methyl methane sulfonate (MMS) and replication arrest induced by hydroxyurea. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.
messages: P-body
messages: The gene for SUS1 bears 2 introns, and its expression is highly regulated by splicing, translation and decay. The presence of the introns thereby play a key role for SUS1 function in yeast.
messages: nucleoplasm

559292:YLL026W
gene id: 559292:YLL026W
uniprot id: P31539
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: By heat stress dependent on the heat shock transcription factor HSF1 and the general stress transcription factors MSN2 and MSN4. Expressed at a higher level in respiring cells than in fermenting cells. Expressed in stationary phase cells and spores (at protein level).
messages: Cytoplasm
messages: Has 2 AAA ATPase type nucleotide-binding domains (NBDs) per monomer, a low-affinity, high-turnover site (NBD1) and a high-affinity site (NBD2) with a 300-fold slower rate of hydrolysis. There is allosteric regulation between the 2 sites. ATP binding to NBD1 triggers binding of polypeptides and stimulates ATP hydrolysis at NBD2. Nucleotide binding to NBD2 is crucial for oligomerization.
messages: Homohexamer, forming a ring with a central pore. The hexamer is stabilized by high protein concentrations and by ADP or ATP. Oligomerization influences ATP hydrolysis activity at NBD2. Interacts with YDJ1. Interacts (via C-terminal DDLD tetrapeptide) with CNS1, CPR7 and STI1 (via TPR repeats); under respiratory growth conditions.
messages: Inhibited by micromolar concentrations of guanidinium chloride. Inhibits the ATPase activity, but does not dissociate the hexameric protein.
messages: Nucleus
messages: Present with 32800 molecules/cell in log phase SD medium.
messages: Required, in concert with Hsp40 (YDJ1) and Hsp70 (SSA1) and small Hsps (HSP26), for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by components of the Hsp70/Hsp40 chaperone system. Substrate binding is ATP-dependent, and release of bound polypeptide is triggered by ATP hydrolysis. Also responsible for the maintenance of prions by dissociating prion fibrils into smaller oligomers, thereby producing transmissible seeds that can infect daughter cells during mitosis and meiosis. Loss of HSP104 can cure yeast cells of the prions [PSI+], [URE3] and [PIN+]. Excess HSP104 can also specifically cure cells of [PSI+].
messages: The C-terminal extension is involved in oligomerization.

559292:YMR309C
gene id: 559292:YMR309C
uniprot id: P32497
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Present with 78900 molecules/cell in log phase SD medium.
messages: The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. A subcomplex of TIF32, NIP1 and PRT1 mediates the interaction with eIF-1, TIF5/eIF-5 and HCR1. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. TIF32, NIP1 and TIF5/eIF-5 comprise a minimal 40S-ribosome-binding unit. NIP1 interacts with TIF5/eIF-5 and SUI1.

559292:YDR312W
gene id: 559292:YDR312W
uniprot id: Q12153
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.
messages: Present with 1350 molecules/cell in log phase SD medium.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

559292:YNL233W
gene id: 559292:YNL233W
uniprot id: P53858
names: Disruption Phenotype
names: Subunit
messages: CHS3 abnormally localized to vacuole.
messages: May interact with CHS3 and seems to be an adapter (along with SKT5) to link CHS3 to septins.

559292:YEL057C
gene id: 559292:YEL057C
uniprot id: P39983
names: Function
messages: Acts as a endogenous target of the ribosome quality control (RQC) pathway (PubMed:32203490). During translation, the nascent chain has a propensity to stall ribosomes, thereby stimulating activation of the RQC pathway (PubMed:32203490).

559292:YJL137C
gene id: 559292:YJL137C
uniprot id: P47011
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
messages: Cytoplasm
messages: Interacts with glycogen synthase GSY2.
messages: Present with 981 molecules/cell in log phase SD medium.
messages: Self-glucosylating initiator of glycogen synthesis. Catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues. These chains act as primers for the elongation reaction catalyzed by glycogen synthase. Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives.

559292:YFL067W
gene id: 559292:YFL067W
uniprot id: P43537
names: Subcellular Location Annotation
messages: Membrane

559292:YGR231C
gene id: 559292:YGR231C
uniprot id: P50085
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prohibitin family.
messages: Mitochondrial targeting of PHB2 is ensured by a bipartite non-cleavable presequence at the N-terminus.
messages: Mitochondrion inner membrane
messages: Present with 2850 molecules/cell in log phase SD medium.
messages: Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
messages: The N-terminus is blocked.
messages: The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa.

559292:YNL124W
gene id: 559292:YNL124W
uniprot id: P53919
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAF1 family.
messages: During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains CBF5, NAF1, NHP2 and NOP10 proteins. Interacts with SHQ1. Interacts directly with CBF5. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (RPB1).
messages: Nucleus
messages: Present with 1810 molecules/cell in log phase SD medium.
messages: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex. Acts as a competitive binder for CBF5 probably required to prevent non-cognate RNAs from being loaded during transport of the particle by inducing a non-productive conformation of CBF5.
messages: The central region (136-221) reveals a striking structural homology with the core domain of GAR1.

559292:YOR156C
gene id: 559292:YOR156C
uniprot id: Q12216
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autosumoylated upon ethanol stress.
messages: Belongs to the PIAS family.
messages: Interacts with CDC12.
messages: May act as an E3 ligase mediating SUMO/Smt3 attachment to septins. May be involved in chromosome maintenance.
messages: Nucleus
messages: Present with 3170 molecules/cell in log phase SD medium.

559292:YBR084W
gene id: 559292:YBR084W
uniprot id: P09440
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Mitochondrial isozyme of C-1-tetrahydrofolate synthase. The trifunctional enzyme catalyzes the interconversion of the one-carbon derivatives of tetrahydrofolate (THF) between different oxidation states by the enzymatic activities 10-formyltetrahydrofolate synthetase, 5,lO-methenyltetrahydrofolate cyclohydrolase, and 5,lO-methylenetetrahydrofolate dehydrogenase.
messages: Mitochondrion
messages: Present with 11400 molecules/cell in log phase SD medium.
messages: This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity.

559292:YBR092C
gene id: 559292:YBR092C
uniprot id: P24031
names: Miscellaneous
names: Similarity
messages: Belongs to the histidine acid phosphatase family.
messages: Present with 952 molecules/cell in log phase SD medium.

559292:YEL031W
gene id: 559292:YEL031W
uniprot id: P39986
names: Activity Regulation
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Contains a large substrate-binding pocket that recognizes alpha-helical transmembranes, which alternately faces the endoplasmic reticulum lumen and cytosol, while remaining accessible to the lipid bilayer through a lateral opening (PubMed:32973005). The translocase alternates between two conformations: inward-open (E1) and outward-open (E2) states (PubMed:32973005). Undergoes a series of conformational changes with ATP-binding, phosphorylation of the Asp active site and subsequent dephosphorylation in a Post-Albers cycle (i.e., E1 -> E1-ATP -> E1P-ADP -> E1P -> E2P -> E2-Pi -> E1) (PubMed:32973005). A substrate transmembrane helix with a short, preferentially positively charged lumenal segment binds to the outward-open pocket and the E2P-to-E1 transition flips the transmembrane by a switch from the outward-open to inward-open conformation (PubMed:32973005).
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:22918956, PubMed:32973005). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005).
messages: Impaired mitochondrial transmembrane tail-anchored protein localization, characterized by mitochondrial transmembrane tail-anchored protein accumulation at the endoplasmic reticulum (PubMed:22918956). In addition, a wide spectrum of phenotypes is observed, including induction of the endoplasmic reticulum unfolded protein response, defects in lipid and sterol homeostasis, and dysregulated protein N-glycosylation, topogenesis and turnover (PubMed:12058017, PubMed:22918956, PubMed:24392018).
messages: Present with 1870 molecules/cell in log phase SD medium.
messages: The ATPase activity is stimulated by phosphatidylinositol 4-phosphate (PI4P).
messages: Was initially thought to mediate ion transport such as calcium or manganese (PubMed:12058017, PubMed:24392018). However, different publications have shown that it does not act as an ion transporter (PubMed:22745129, PubMed:32353073, PubMed:32973005). Specifically binds moderately hydrophobic transmembrane with short hydrophilic lumenal domains that misinsert into the endoplasmic reticulum (PubMed:32973005).

559292:YOR129C
gene id: 559292:YOR129C
uniprot id: Q99222
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AFI1/mesA family.
messages: Interacts with ARF3 (in GTP-bound form). Interacts with CNM67.
messages: Involved in actin patch polarization. Required for maintaining a proper budding pattern in yeast cells. Required for proper polarized localization of the ADP-ribosylation factor ARF3 at the plasma membrane.
messages: Mainly expressed in dividing cells, but not in stationary phase cells (at protein level).
messages: Present with 768 molecules/cell in log phase SD medium.
messages: cell cortex
messages: perinuclear region

559292:YGL246C
gene id: 559292:YGL246C
uniprot id: P53063
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (PubMed:12897126, PubMed:20802481, PubMed:26101253). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:12897126, PubMed:20802481). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (PubMed:20802481). Stimulates exoribonuclease activity of RAT1, allowing it to degrade RNAs with stable secondary structure more effectively (PubMed:20802481). Required for the processing of nuclear mRNA and rRNA precursors (PubMed:10805743, PubMed:12612077, PubMed:16131592). May promote termination of transcription by RNA polymerase II (PubMed:15565157).
messages: Divalent metal cation.
messages: Interacts with RAT1, RTT103 and pre-60S ribosomal subunits.
messages: Nucleus
messages: Present with 4030 molecules/cell in log phase SD medium.

559292:YER023W
gene id: 559292:YER023W
uniprot id: P32263
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline, the final step in proline biosynthesis.
messages: Homotetramer.
messages: Present with 43500 molecules/cell in log phase SD medium.

559292:YLR268W
gene id: 559292:YLR268W
uniprot id: P22214
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptobrevin family.
messages: Component of two distinct SNARE complexes consisting of SED5, BOS1, BET1 and SEC22 or UFE1, USE1, SEC20 and SEC22. YKT6 can probably replace SEC22 as subunit of either complex. Interacts with SEC24, YIF1 and YIP1.
messages: Deletion of SEC22 is viable. Overexpression of SEC22 suppresses deletion of YPT1.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Nonessential SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YGR200C
gene id: 559292:YGR200C
uniprot id: P42935
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ELP2 family.
messages: Component of the elongator complex which consists of ELP1/IKI3, ELP2, ELP3, ELP4, ELP5/IKI1 and ELP6 (PubMed:11435442, PubMed:11689709, PubMed:27974378, PubMed:27872205). The elongator complex is composed of two copies of the Elp123 subcomplex (composed of ELP1/IKI3, ELP2 and ELP3) and two copies of the Elp456 subcomplex (composed of ELP4, ELP5/IKI1 and ELP6) (PubMed:27974378, PubMed:27872205, PubMed:25960406). The Elp123 subcomplex forms a two-lobed scaffold, which binds the Elp456 subcomplex asymmetrically (PubMed:27974378, PubMed:27872205). In the complex, ELP2 interacts with ELP1/IKI3 (PubMed:12139626). In each lobe, ELP2 is tightly sandwiched between ELP1/IKI3 and ELP3 (PubMed:31309145). The Elp123 subcomplex binds tRNA through ELP1/IKI3 and ELP3 and can bind 2 tRNAs simultaneously (PubMed:31309145). tRNA-binding induces conformational rearrangements which precisely position the targeted anticodon base in the active site (PubMed:31309145). The Elp456 subcomplex binds tRNA and has ATPase activity (PubMed:22343726). Interacts with KTI11/DPH3 (PubMed:27694803, PubMed:18627462).
messages: Component of the elongator complex, a multiprotein complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837, PubMed:31309145). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368). ELP2 binds to microtubules (PubMed:25960406). Independently, ELP2 may be involved in polarized exocytosis (PubMed:15138274, PubMed:15780940).
messages: Cytoplasm
messages: Folds into a two seven-bladed beta-propeller structure which is required for elongator complex assembly and association with microtubules.
messages: Nucleus
messages: Present with 6090 molecules/cell in log phase SD medium.
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

559292:YDR080W
gene id: 559292:YDR080W
uniprot id: P38959
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS41 family.
messages: Component of the HOPS complex which is composed of PEP5, VPS16, PEP3, VPS33, VPS39 and VPS41. HOPS associates with phosphoinositides and the PX domain of VAM7. Interacts with VAM7 and VPS39.
messages: Present with 1170 molecules/cell in log phase SD medium.
messages: Required for vacuolar assembly and vacuolar traffic. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
messages: Vacuole

559292:YBL008W-A
gene id: 559292:YBL008W-A
uniprot id: Q3E821
names: Subcellular Location Annotation
messages: Secreted

559292:YPR107C
gene id: 559292:YPR107C
uniprot id: Q06102
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of at least PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Interacts with FIP1 and YSH1.
messages: Nucleus
messages: Present with 3690 molecules/cell in log phase SD medium.
messages: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.

559292:YLR262C-A
gene id: 559292:YLR262C-A
uniprot id: Q3E764
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMA7 family.
messages: Cytoplasm
messages: Interacts with the 40S ribosomal subunit.
messages: Involved in protein synthesis.
messages: Nucleus
messages: Present with 3100 molecules/cell in log phase SD medium.

559292:YMR095C
gene id: 559292:YMR095C
uniprot id: Q03144
names: Function
names: Similarity
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform.

559292:YOR272W
gene id: 559292:YOR272W
uniprot id: Q12024
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (PubMed:12110181, PubMed:16287855, PubMed:26657628). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (By similarity) (PubMed:20542003, PubMed:26601951).
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Present with 6670 molecules/cell in log phase SD medium.
messages: nucleolus
messages: nucleoplasm

559292:YNR077C
gene id: 559292:YNR077C
uniprot id: P53758
names: Induction
names: Similarity
messages: Belongs to the UPF0320 family.
messages: Induced 4.5-fold when shifted from galactose to glucose medium (at protein level).

559292:YBR169C
gene id: 559292:YBR169C
uniprot id: P32590
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: By upshift to 37 degrees Celsius.
messages: Has a calcium-dependent calmodulin-binding activity.
messages: Present with 6300 molecules/cell in log phase SD medium.

559292:YGR063C
gene id: 559292:YGR063C
uniprot id: P32914
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Chromosome
messages: Component of the SPT4-SPT5 complex. Interacts with SHE2.
messages: Nucleus
messages: Present with 4490 molecules/cell in log phase SD medium.
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. The complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. Structural and functional component of the centromeric and heterochromatic loci linking chromatin structure with kinetochore function and gene silencing.
messages: Was originally thought to be involved in the transcription initiation step.
messages: centromere

559292:YJL156C
gene id: 559292:YJL156C
uniprot id: P47002
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S64 family.
messages: Cell membrane
messages: Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex.
messages: Down-regulated after extracellular amino-acid addition.
messages: Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1.
messages: The propeptide is autoproteolytically cleaved from the catalytic domain but remains associated, forming an inactive protease complex. This processing occurs even in the absence of signaling.

559292:YLR344W
gene id: 559292:YLR344W
uniprot id: P05743
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: There are 2 genes for uL24 in yeast.

559292:YHR150W
gene id: 559292:YHR150W
uniprot id: P38848
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-2832 family. Peroxin-28 subfamily.
messages: Involved in the regulation of peroxisome number, size and distribution.
messages: Peroxisome membrane

559292:YMR183C
gene id: 559292:YMR183C
uniprot id: P39926
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Present with 1720 molecules/cell in log phase SD medium.
messages: Required for vesicle fusion with the plasma membrane.

559292:YPL191C
gene id: 559292:YPL191C
uniprot id: Q08930
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Cytoplasm
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has endodeubiquitinase activity.
messages: Present with 2050 molecules/cell in log phase SD medium.

559292:YBL071W-A
gene id: 559292:YBL071W-A
uniprot id: Q3E840
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH3 family.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:12940988, PubMed:27694803, PubMed:18627462, PubMed:23645155). Interacts with DPH1 (PubMed:12940988, PubMed:27694803, PubMed:18627462, PubMed:23645155). Interacts with DPH2 (PubMed:12940988, PubMed:27694803, PubMed:18627462). Interacts with CBR1 (PubMed:27694803). Interacts with elongation factor 2 (PubMed:12940988). Interacts with ATS1/KTI13; the interaction is direct (PubMed:25604895, PubMed:25543256, PubMed:18627462). Interacts with the 40S ribosomal protein RPS7A (PubMed:12940988). Interacts with the 40S ribosomal protein RPS19A (PubMed:12940988). Interacts with the elongator complex subunit IKI3/ELP1 (PubMed:12940988, PubMed:18986986, PubMed:27694803). Interacts with the elongator complex subunit ELP2 (PubMed:12940988, PubMed:18986986, PubMed:27694803, PubMed:18627462). Interacts with the elongator complex subunit ELP3 (PubMed:12940988, PubMed:18986986, PubMed:27694803). Interacts with the elongator complex subunit ELP5 (PubMed:18627462).
messages: Cytoplasm
messages: Nucleus
messages: Present with 8400 molecules/cell in log phase SD medium.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:18627462, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323, PubMed:25543256). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323). Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state (PubMed:34154323). Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM (PubMed:34154323). Together with ATS1; associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex (PubMed:25543256, PubMed:27694803, PubMed:18627462). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:25543256).
messages: Sensitive to caffeine, paromycin, and thermal stress (PubMed:18627462). Resistance to diphtheria toxin, sordarin and zymocin (PubMed:27694803, PubMed:18627462).
messages: The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.

559292:YDL112W
gene id: 559292:YDL112W
uniprot id: Q07527
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Cytoplasm
messages: Present with 861 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs.

559292:YMR118C
gene id: 559292:YMR118C
uniprot id: Q04487
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b560 family.
messages: Does not affect SDH or TIM22 complex formation.
messages: Homolog of SDH3, but seems not to be a stoichiometric subunit of either the succinate dehydrogenase (SDH) complex or the mitochondrial inner membrane translocase TIM22 complex.
messages: Mitochondrion inner membrane

559292:YOR381W
gene id: 559292:YOR381W
uniprot id: Q08905
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: By iron deprivation.
messages: Cell membrane
messages: Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane.

559292:YLL022C
gene id: 559292:YLL022C
uniprot id: Q12373
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NASP family.
messages: Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing.
messages: Homodimer (PubMed:27618665). The homodimer interacts with a histone tetramer containing H3 and H4; the interaction is direct (PubMed:24946827, PubMed:27618665). The homodimer interacts with heterodimeric histone H2A and H2B; the interaction is direct (PubMed:24946827, PubMed:27618665). Component of the nuclear histone acetyltransferase B (HAT-B) complex composed of at least HAT1, HAT2 and HIF1 (PubMed:14761951, PubMed:15099519). Does not interact with HAT1 in the absence of HAT2 (PubMed:14761951, PubMed:24946827). Interacts with histones H3 and H4 in a HAT1/HAT2 dependent manner (PubMed:14761951, PubMed:15099519). Interaction with heterotetrameric histone H3 and H4 precludes interaction with dimeric histone H2A and H2B, irrespective of the fact that their binding involves non-identical regions of the protein (PubMed:24946827, PubMed:27618665).
messages: Nucleus
messages: Present with 4550 molecules/cell in log phase SD medium.
messages: The N-terminal TPR repeat region contains an acidic patch that is important for interaction with histones (PubMed:24946827, PubMed:27618665). A C-terminal, highly polar region mediates interaction with dimeric histone H2A and H2B, but is not involved in interaction with heterotetrameric histone H3 and H4 (PubMed:27618665).

559292:YNL107W
gene id: 559292:YNL107W
uniprot id: P53930
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SWR1 chromatin-remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1. Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Interacts with SWC4.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.
messages: Cytoplasm
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.
messages: The coiled-coil domain is required for assembly into the NuA4 complex.

559292:YPR033C
gene id: 559292:YPR033C
uniprot id: P07263
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.
messages: Cytoplasm
messages: Lethal.
messages: Mitochondrion
messages: Present with 26800 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-21 of isoform Mitochondrial.

559292:YGL104C
gene id: 559292:YGL104C
uniprot id: P53142
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: May be involved in vacuolar protein sorting.
messages: Mitochondrion membrane

559292:YPL266W
gene id: 559292:YPL266W
uniprot id: P41819
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.
messages: nucleolus

559292:YKL179C
gene id: 559292:YKL179C
uniprot id: P34237
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: May be involved in intra-Golgi transport.
messages: Present with 2650 molecules/cell in log phase SD medium.

559292:YIL079C
gene id: 559292:YIL079C
uniprot id: P40507
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AIR1 family.
messages: Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. AIR1 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1.
messages: Component of the TRAMP complex (also called TRF4 complex) composed of at least HUL4, MTR4, PAP2/TFR4 and either AIR1 or AIR2. Component of the TRAMP5 complex composed of at least AIR1, MTR4 and TRF5. Interacts with HMT1 and NPL3. The interaction with NPL3 requires the presence of HMT1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1550 molecules/cell in log phase SD medium.

559292:YML081C-A
gene id: 559292:YML081C-A
uniprot id: P81450
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase j subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane
messages: Present with 6540 molecules/cell in log phase SD medium.

559292:YLR163C
gene id: 559292:YLR163C
uniprot id: P10507
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Binding to MAS2 is required for catalytic activity (PubMed:9654444, PubMed:9299349). Inhibited by high levels (> 1uM) of zinc (PubMed:9654444). Inhibited by metal chelators ethylenediaminetetraacetic acid (EDTA) and O-phenanthroline (PubMed:9654444).
messages: Binds 1 zinc ion per subunit.
messages: Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (PubMed:2007593, PubMed:9299349, PubMed:9654444). Preferentially, cleaves after an arginine at position P2 (By similarity).
messages: Heterodimer of MAS2 (alpha) and MAS1 (beta) subunits, forming the mitochondrial processing protease (MPP) in which MAS2 is involved in substrate recognition and binding and MAS1 is the catalytic subunit.
messages: Mitochondrion matrix
messages: Present with 1360 molecules/cell in log phase SD medium.
messages: Simultaneous disruption of the mitochondrial presequence protease CYM1 results in synthetic lethality in respiratory conditions.

559292:YAL024C
gene id: 559292:YAL024C
uniprot id: P07866
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTE1 family.
messages: Bud
messages: Cytoplasm
messages: GDP-GTP exchange factor for TEM1, a Ras-like protein, component of the mitotic exit network (MEN). Activation of TEM1 by LTE1 in the bud ultimately leads to activation of CDC15 followed by the release of CDC14 from the nucleolus, which then inactivates cyclin-dependent kinases (CDKs) activity by several mechanism. Required for TEM1 localization to the bud cortex during mitotic exit. Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis.
messages: Interacts with CDC24, CDC42, KEL1, KEL2, RAS2 and TEM1.
messages: Involved in proprotein-processing like proalpha factor-processing in the secretory pathway.
messages: Phosphorylated by CDC28 in a cell cycle-dependent manner and in response to nocodazole. Dephosphorylion by CDC14 triggers LTE1 release from bud cortex during the exit of mitosis.
messages: Present with 304 molecules/cell in log phase SD medium.

559292:YBR012W-B
gene id: 559292:YBR012W-B
uniprot id: Q12193
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YBR012W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YLR154W-C
gene id: 559292:YLR154W-C
uniprot id: Q8TGM6
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Encoded on the antisense strand of the nuclear 25S rDNA.
messages: May be involved in mtDNA stability or mitochondrial gene expression regulation at the post-transcriptional level.
messages: Mitochondrion

559292:YDR452W
gene id: 559292:YDR452W
uniprot id: Q04119
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endopolyphosphatase PPN1 family.
messages: Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths both by cleaving phosphate from the chain end and by fragmenting long-chain polymers into shorter ones. The limited digestion products are 1 and 3 P(i) residues (PubMed:11102525, PubMed:11447286, PubMed:15170373, PubMed:15342119, PubMed:15792812, PubMed:8900207, Ref.16). Also releases phosphate from dATP. dATP phosphohydrolase activity is about 7-fold lower than the exopolyphosphatase activity (Ref.16).
messages: Cytoplasm
messages: Divalent metal cations. Exopolyphosphatase activity is predominant in the presence of Co(2+), while endopolyphosphatase activity is predominant in the presence of Mg(2+) (PubMed:8900207, PubMed:25742176). Co(2+) is more effective than Mn(2+) for dATP phosphohydrolase activity (Ref.16).
messages: Homotetramer.
messages: Inactivation of PPN1 leads to the inhibition of expression of both exopolyphosphatase PPX1 and high-molecular-mass exopolyphosphatase not encoded by PPX1.
messages: Inhibited by heparin and EDTA.
messages: N-glycosylated (Probable). N-glycosylation is essential for the protease-mediated maturation.
messages: Present with 319 molecules/cell in log phase SD medium.
messages: Processing by proteases in the vacuole is required for activation.
messages: The transmembrane domain contains polar residues that mediate the recognition by TUL1.
messages: Ubiquitinated. Ubiquitination mediates sorting into internal vesicles in late endosomes. TUL1 and RSP5 are required for ubiquitination. Other cytoplasmic Lys residues than Lys-6 may also be ubiquitinated.
messages: Vacuole membrane

559292:YNR072W
gene id: 559292:YNR072W
uniprot id: P53631
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Probable glucose transporter.

559292:YNL062C
gene id: 559292:YNL062C
uniprot id: P41814
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer; composed of two copies of TRM6/GCD10 and two copies of TRM61/GCD14.
messages: Nucleus
messages: Present with 2580 molecules/cell in log phase SD medium.
messages: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:10779558, PubMed:9851972). Also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency (PubMed:7542616).

559292:YLR167W
gene id: 559292:YLR167W
uniprot id: P05759
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Ubiquitin is encoded by several different genes. UBI1 and UBI2 genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40. UBI3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. UBI4 is a polyprotein containing 5 exact head to tail repeats of ubiquitin.

559292:YOR373W
gene id: 559292:YOR373W
uniprot id: P32336
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts directly with MPC54, CNM67, SPO21/MPC70, ADY3 and ADY4. Probable component of a spindle pole boby (SPB) complex composed of ADY3, SSP1, DON1, MPC54, SPO21/MPC70, NUD1 and CNM67.
messages: Involved in astral microtubule organization by binding SCP72 to the outer plaque in a cell-cycle dependent manner. Required for the mitotic exit by facilitating the binding of TEMP1 to CDC15. Also involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation.
messages: Nucleus envelope
messages: Phosphorylated from S/G2 phase until the end of mitosis.
messages: Present with 892 molecules/cell in log phase SD medium.
messages: spindle pole body

559292:YOL136C
gene id: 559292:YOL136C
uniprot id: Q12471
names: Function
names: Induction
messages: By glucose and fructose, but not by galactose or maltose.
messages: Synthesis of fructose 2,6-bisphosphate.

559292:YJL072C
gene id: 559292:YJL072C
uniprot id: P40359
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3. Interacts with PSF1 and SLD5.
messages: Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.
messages: Nucleus

559292:YGR095C
gene id: 559292:YGR095C
uniprot id: P53256
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:17173052 and PubMed:17174896, only DIS3/RRP44 subunit of the exosome core has exonuclease activity.
messages: Belongs to the RNase PH family.
messages: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure. Interacts with LRP1.
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP46 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.
messages: Present with 10800 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR321C
gene id: 559292:YLR321C
uniprot id: Q06168
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression.
messages: Interacts directly with STH1. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
messages: Nucleus
messages: Phosphorylated in the G1 phase.
messages: Present with 3940 molecules/cell in log phase SD medium.

559292:YDR022C
gene id: 559292:YDR022C
uniprot id: Q12421
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Forms a stable complex with ATG17 and ATG29. Interacts directly with ATG29. The ATG17-ATG29-ATG31 complex interacts with the ATG1-ATG13 complex. Note=The interaction with the ATG1-ATG13 complex is induced by starvation.
messages: Phosphorylated.
messages: Plays a role in starvation-induced autophagy. Involved in mitophagy. Functions with ATG17 and ATG29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. May be involved in microtubule function, such as chromosome segregation and karyogamy.
messages: Preautophagosomal structure
messages: Present with 486 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YMR163C
gene id: 559292:YMR163C
uniprot id: Q03824
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INP2 family.
messages: Interacts with MYO2.
messages: Peroxisome membrane
messages: Present with 736 molecules/cell in log phase SD medium.
messages: Required for peroxisome inheritance. Acts as the peroxisome-specific receptor for the myosin V motor MYO2.

559292:YLR460C
gene id: 559292:YLR460C
uniprot id: P54007
names: Miscellaneous
names: Similarity
messages: Belongs to the YCR102c/YLR460c/YNL134c family.
messages: Present with 799 molecules/cell in log phase SD medium.

559292:YLR329W
gene id: 559292:YLR329W
uniprot id: Q02721
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TOP6B-like family.
messages: Despite weak sequence similarities, may correspond to the subunit B of a SPO11-containing topoisomerase 6 complex specifically required for meiotic recombination. Retains some of the structural features of the ancestral archaeal Top6B subunit (AC O05207).
messages: Interacts with REC104; seems to form a functional unit with REC104. REC102-REC104 interacts with SKI8-SPO11 and this interaction is required for proper subcellular location of the proteins during the initiation of recombination. Interacts with MEI4, REC114 and SPO11.
messages: Meiosis-specific. mRNA is spliced only during meiosis.
messages: Nucleus
messages: Reduces meiotic recombination several hundred fold. Specifically affects meiosis, and does not have any detectable mitotic phenotype.
messages: Required for formation of the SPO11-mediated double-strand breaks (DSBs) that initiate meiotic recombination. May mediate the interaction between SPO11 subunits during meiosis. Also needed for homolog chromosome pairing, synaptonemal complex formation, and for the proper timing of the first meiotic division. Not required for mitosis and mitotic DNA repair mechanisms.

559292:YGR031W
gene id: 559292:YGR031W
uniprot id: P53219
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Mitochondrion
messages: Present with 7400 molecules/cell in log phase SD medium.
messages: Probable alcohol acetyltransferase that uses acetyl-CoA to synthesize acetate esters from various alcohols (Probable). Not involved in the synthesis of ethyl acetate (PubMed:28356220).
messages: Processed by both the mitochondrial processing peptidase (MPP) and the mitochondrial octapeptidyl aminopeptidase (OCT1).
messages: The gene contains the nested antisense gene NAG1.

559292:YPL128C
gene id: 559292:YPL128C
uniprot id: Q02457
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. 52 binding sites have been identified, distributed over 15 chromosomes. A member of the general regulatory factors (GRFs) which act as genome partitioners. Acts as a chromatin insulator which are known as STARs (Subtelomeric anti-silencing region). STARs prevent negative or positive transcription influence by extending across chromatin to a promoter.
messages: Homodimer.
messages: Nucleus
messages: Present with 6380 molecules/cell in log phase SD medium.
messages: telomere

559292:YGR256W
gene id: 559292:YGR256W
uniprot id: P53319
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YIR027C
gene id: 559292:YIR027C
uniprot id: P32375
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring. Involved in the utilization of purines as secondary nitrogen sources, when primary sources are limiting.
messages: Homotetramer.

559292:YLR186W
gene id: 559292:YLR186W
uniprot id: Q06287
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Depletion of EMG1 affects growth and leads to strong ribosome biogenesis defects, with defects in 20S pre-rRNA and mature 18S rRNA species.
messages: Homodimer. Interacts with snoRNA U3. Interacts with NOP14 and MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1189 (Psi1189) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. N1-methylation is independent on acp-modification at the N3-position of U1191. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 (RPS19A/RPS19B) during the formation of pre-ribosomes.
messages: nucleolus

559292:YNL018C
gene id: 559292:YNL018C
uniprot id: P53976
names: Similarity
messages: To yeast YNL034w.

559292:YIL137C
gene id: 559292:YIL137C
uniprot id: P40462
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with ribosomal complexes.
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Present with 5110 molecules/cell in log phase SD medium.
messages: Putative zinc aminopeptidase which may be involved in ribosome biogenesis.

559292:YOL146W
gene id: 559292:YOL146W
uniprot id: Q12146
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.
messages: Nucleus
messages: Present with 2205 molecules/cell in log phase SD medium.

559292:YLL035W
gene id: 559292:YLL035W
uniprot id: Q07845
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
messages: Cell cycle-regulated with a peak of transcription at the G1/S boundary.
messages: Polynucleotide 5'-kinase involved in rRNA processing. Required for the efficient termination by RNA polymerase I and the processing of the IST2 pre-rRNA internal transcribed spacer localized between the 5.8S and 25S rRNAs. May act by maintaining the phosphorylated status of the downstream RNT1 cleavage product, which in turn allows the torpedo activity of RAT1 to efficiently terminate Pol I transcription. In vitro, displays polynucleotide kinase activity on both single- and double-stranded RNA and on single-stranded DNA alone, but not double-stranded DNA alone.
messages: nucleolus

559292:YNL267W
gene id: 559292:YNL267W
uniprot id: P39104
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate (PubMed:8194527, PubMed:8248783). PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton (PubMed:8194527). Involved in the response to mating pheromone (PubMed:8248783).
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Interacts with FRQ1.
messages: Nucleus
messages: Present with 1600 molecules/cell in log phase SD medium.

559292:YJR112W
gene id: 559292:YJR112W
uniprot id: P47149
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. NNF1 is required for a number of nuclear functions. Cells depleted of NNF11 or containing a temperature-sensitive NNF1 mutation have elongated microtubules and become bi- and multinucleate. They also have a fragmented nucleolus and accumulate poly(A)+ RNA inside the nucleus.
messages: Component of the MIND kinetochore complex, which is composed of at least MTW1, NNF1, NSL1 and DSN1.
messages: Nucleus
messages: Present with 2070 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YLR192C
gene id: 559292:YLR192C
uniprot id: Q05775
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Marked reduction in binding of the eIF-3 core complex to 40S ribosomes.
messages: Present with 17900 molecules/cell in log phase SD medium.
messages: Probable component of the eukaryotic translation initiation factor 3 (eIF-3) complex. Is not part of the eIF-3 core complex, with which it is associated in substochiometric amounts.

559292:YFR036W
gene id: 559292:YFR036W
uniprot id: P14724
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: Nucleus
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1. CDC26 is required to tether the essential subunits APC9, CDC27 and CDC16 to the complex.
messages: Was originally thought to be a suppressor of CDC26.

559292:YMR123W
gene id: 559292:YMR123W
uniprot id: Q03880
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PKR1 family.
messages: Endoplasmic reticulum membrane
messages: Functions together with the other V-type ATPase assembly factors in the endoplasmic reticulum to efficiently assemble the V-type ATPase membrane sector V(0).
messages: Present with 5750 molecules/cell in log phase SD medium.

559292:YIL104C
gene id: 559292:YIL104C
uniprot id: P40486
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHQ1 family.
messages: Interacts with CBF5, NAF1 and NHP2. The interaction with NAF1 and SHQ1 does not occur when NAF1 is associated with the chromatin.
messages: Involved in the early biogenesis steps of box H/ACA snoRNP assembly.
messages: Nucleus
messages: Present with 7060 molecules/cell in log phase SD medium.

559292:YHR183W
gene id: 559292:YHR183W
uniprot id: P38720
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Cytoplasm
messages: Homodimer.
messages: Present with 101000 molecules/cell in log phase SD medium.

559292:YER157W
gene id: 559292:YER157W
uniprot id: P40094
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG3 is also involved in actin cytoskeleton organization.
messages: Belongs to the COG3 family.
messages: Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.
messages: Golgi apparatus membrane
messages: Present with 4140 molecules/cell in log phase SD medium.

559292:YHR160C
gene id: 559292:YHR160C
uniprot id: P38855
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with PEX7; The interaction with PEX7 stabilizes PEX18 (PubMed:12167700, PubMed:11590152, PubMed:9864360, PubMed:11606420). Interacts with PEX13 (PubMed:12167700).
messages: Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2 (PubMed:12167700, PubMed:15456864, PubMed:9864360). Required for peroxisomal targeting of PEX7 and growth on oleate (PubMed:12167700, PubMed:15456864, PubMed:9864360).
messages: Peroxisome membrane
messages: Ubiquitinated in a UBC4/UBC5 dependent manner.

559292:YEL055C
gene id: 559292:YEL055C
uniprot id: P39985
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MYBBP1A family.
messages: Interacts with FRK1.
messages: Plays an important role in the regulation of rRNA transcription. Binds near or at the enhancer region of rRNA repeating units. May have DNA polymerase activity, but it is not required for in vivo function.
messages: Present with 4490 molecules/cell in log phase SD medium.
messages: Stimulated by PCNA and inhibited by aphidicolin.
messages: Was originally thought to belong to the DNA polymerase type-B family based on conserved motifs (PubMed:12093911). Has later been shown to be unrelated to B class DNA polymerases. The observation of a low level of polymerase activity in vitro, which is not required for its essential cellular function, may require further validation (PubMed:12695662).
messages: nucleolus

559292:YIL092W
gene id: 559292:YIL092W
uniprot id: P40497
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 105 molecules/cell in log phase SD medium.

559292:YKL218C
gene id: 559292:YKL218C
uniprot id: P36007
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the deamination of L-threo-3-hydroxyaspartate to oxaloacetate and ammonia. Shows a high specificity towards L-threo-3-hydroxyaspartate as other 3-hydroxyaminoacids, i.e. D,L-erythro- and D-threo-3-hydroxyaspartate, D-threonine, L-threonine, D,L-allothreonine, D-serine, and L-serine, are not substrates for this enzyme. Exhibits no detectable serine racemase activity. Is responsible for the 3-hydroxyaspartate resistance of S.cerevisiae, and thus may be involved in the detoxification of naturally occurring 3-hydroxyaspartate.
messages: Cells lacking this gene grow as well as the wild-type parent strain on SD medium, but fail to grow on hydroxyaspartate-containing agar plate.
messages: Is strongly inhibited by hydroxylamine and EDTA in vitro.
messages: Monomer.
messages: Requires a divalent metal cation such as Mn(2+), Mg(2+), or Ca(2+).

559292:YNL165W
gene id: 559292:YNL165W
uniprot id: P53891
names: Similarity
messages: To yeast YMR316w.

559292:YER072W
gene id: 559292:YER072W
uniprot id: P40046
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046). The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046). PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834). VTC1 contributes only 3 transmembrane domains to the complex (Probable). The VTC complex also plays a role in vacuolar membrane fusion (PubMed:10480897, PubMed:11102525, PubMed:11823419, PubMed:12584253). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419).
messages: Belongs to the VTC1 family.
messages: By low phosphate.
messages: Endoplasmic reticulum membrane
messages: Present with 12074 molecules/cell in log phase SD medium.
messages: The VTC core complex is an integral membrane heterooligomer composed of the catalytic subunit VTC4 and the accessory subunits VTC1, VTC2 and VTC3. The complex exists in 2 different sub-complexes: VTC1-VTC2-VCT4 and VCT1-VTC3-VTC4. The VCT1-VTC3-VTC4 subcomplex is mostly found on the vacuolar membrane. The VTC1-VTC2-VCT4 subcomplex is observed in the cell periphery, probably ER and nuclear envelope, but localizes to the vacuole under phosphate starvation. Each subunit contains 3 transmembrane helices. VTC1 is a small membrane protein without hydrophilic domain. VTC2, VTC3 and VTC4 are related and have 2 hydrophilic domains that face the cytosol, an N-terminal SPX domain and the central core domain. The central core in VTC4 is the catalytic domain, with the essential catalytic lysine replaced by isoleucine and leucine in VTC2 and VTC3, respectively (PubMed:19390046). The core complex associates with the accessory subunit VTC5 (PubMed:27587415). The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1 (PubMed:11823419).
messages: Vacuole membrane
messages: autophagosome membrane
messages: cell cortex

559292:YBR253W
gene id: 559292:YBR253W
uniprot id: P32570
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. SRB6/MED22 interacts directly with SRB4/MED17.
messages: Nucleus
messages: Present with 2181 molecules/cell in log phase SD medium.

559292:YNL162W
gene id: 559292:YNL162W
uniprot id: P0CX27
uniprot id: P0CX28
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: In wild-type cells, 78% of L42 is monomethylated at both Lys-40 and Lys-55, and 22% are a mixture of species with either residue monomethylated.
messages: Present with 13600 molecules/cell in log phase SD medium.
messages: Present with 3890 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL42 in yeast.

559292:YJR124C
gene id: 559292:YJR124C
uniprot id: P47159
names: Subcellular Location Annotation
messages: Membrane

559292:YDR262W
gene id: 559292:YDR262W
uniprot id: Q12331
names: Miscellaneous
names: Subcellular Location Annotation
messages: Present with 4846 molecules/cell in log phase SD medium.
messages: Vacuole

559292:YDR175C
gene id: 559292:YDR175C
uniprot id: Q03976
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS35 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 3150 molecules/cell in log phase SD medium.

559292:YDR516C
gene id: 559292:YDR516C
uniprot id: Q04409
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Cytoplasm
messages: Present with 10600 molecules/cell in log phase SD medium.
messages: Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake (By similarity). Involved in sporulation. Required for the full activation of the early meiotic inducer IME1.
messages: Repressed by glucose through the MIG1 and MIG2 repressors.

559292:YMR038C
gene id: 559292:YMR038C
uniprot id: P40202
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCS1 family.
messages: Binds 2 copper ions per subunit.
messages: Copper chaperone for apo superoxide dismutase 1 (SOD1). Binds copper ions and delivers them specifically to apo-SOD1.
messages: Cytoplasm
messages: Homodimer, and heterodimer with apo-SOD1. Zinc-binding at His-16 of CCS1 and 'Glu-43' of apo-SOD1 is required for this heterodimerization.
messages: Mitochondrion intermembrane space
messages: Present with 12000 molecules/cell in log phase SD medium.

559292:YOR188W
gene id: 559292:YOR188W
uniprot id: P21339
names: Function
names: Miscellaneous
messages: May play a role in polarity establishment and bud formation. The MSB1 gene may be functionally redundant.
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YDR063W
gene id: 559292:YDR063W
uniprot id: Q12156
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Cytoplasm
messages: May be involved in mitochondrial organization and biogenesis.
messages: Nucleus
messages: Present with 3040 molecules/cell in log phase SD medium.
messages: Sensitive to nickel.

559292:YJR096W
gene id: 559292:YJR096W
uniprot id: P47137
names: Miscellaneous
names: Similarity
messages: Belongs to the aldo/keto reductase family.
messages: Present with 6960 molecules/cell in log phase SD medium.

559292:YFR010W
gene id: 559292:YFR010W
uniprot id: P43593
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Activated by it's association with the proteasome.
messages: Associates with the regulatory particle (RP) of the proteasome.
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Predominant proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Has proteasome-inhibitory activity and delays the degradation of ubiquitinated proteins to provide a time window allowing gradual deubiquitination of the substrate. Stabilizes the association of HUL5 with proteasomes and works in opposition to polyubiquitin elongation activity of HUL5.
messages: Present with 6770 molecules/cell in log phase SD medium.
messages: The N-terminal ubiquitin-like domain is required for proteasome association and UBP6 activation at the proteasome.

559292:YFR035C
gene id: 559292:YFR035C
uniprot id: P43608
names: Subcellular Location Annotation
messages: Membrane

559292:YNL173C
gene id: 559292:YNL173C
uniprot id: P53885
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRP1/MDG1 family.
messages: Cell membrane
messages: Involved in G-protein mediated signal transduction and in the regulation of polarized cell growth in pheromone-induced cells.
messages: Present with 1240 molecules/cell in log phase SD medium.

559292:YNL273W
gene id: 559292:YNL273W
uniprot id: P53840
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the timeless family.
messages: Component of the fork protection complex (FPC) consisting of TOF1 and CSM3. Interacts with WSS1 and ESC4.
messages: Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors and protects stalled replication forks against the fork-releasing activity of RRM3 helicase.
messages: Nucleus
messages: Present with 952 molecules/cell in log phase SD medium.

559292:YIL002C
gene id: 559292:YIL002C
uniprot id: P40559
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptojanin family.
messages: Controls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth.
messages: IRS4 and TAX4 are both positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Interacts with IRS4 and TAX4.
messages: Present with 98 molecules/cell in log phase SD medium.
messages: actin patch

559292:YOL077W-A
gene id: 559292:YOL077W-A
uniprot id: P81451
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP19 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. The K chain binds the dimeric form by interacting with the G and E chains.
messages: Mitochondrion inner membrane
messages: Present with 1320 molecules/cell in log phase SD medium.

559292:YOR236W
gene id: 559292:YOR236W
uniprot id: P07807
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
messages: Present with 1080 molecules/cell in log phase SD medium.

559292:YDR248C
gene id: 559292:YDR248C
uniprot id: Q03786
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconokinase GntK/GntV family.
messages: Cytoplasm
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YHR193C
gene id: 559292:YHR193C
uniprot id: P38879
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and either EGD1 or BTT1. NAC associates with ribosomes via EGD1 or BTT1, and with the CCR4-NOT complex.
messages: Present with 38016 molecules/cell in log phase SD medium.
messages: The UBA domain is required for the stability of EGD1.
messages: Ubiquitinated by the NOT4 E3 ligase and the UBC4 E2 ubiquitin conjugation enzyme.

559292:YLR003C
gene id: 559292:YLR003C
uniprot id: Q07897
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMS1 family.
messages: May play a role in the regulation of DNA replication and cell cycle control.
messages: Nucleus
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YDL058W
gene id: 559292:YDL058W
uniprot id: P25386
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Composed of a globular head region and a rod-like C-terminal coiled coil domain. The rodlike tail sequence is highly repetitive, composed of a heptapeptide repeat pattern characteristic of alpha-helical coiled coils. May form filamentous structures in the cell.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two globular head domains side by side, and a long rod-like tail structure.
messages: Present with 2330 molecules/cell in log phase SD medium.
messages: Required for protein transport from the ER to the Golgi complex.
messages: cytoskeleton

559292:YMR086W
gene id: 559292:YMR086W
uniprot id: Q04279
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEG1 family.
messages: Cell membrane
messages: Component of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains termed MCCs on the plasma membrane.
messages: Important for the biogenesis of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations. Required for efficient incorporation of the eisosome component PIL1 into eisosomes.

559292:YGL210W
gene id: 559292:YGL210W
uniprot id: P51996
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by the guanine nucleotide-exchange factor (GEF) TRAPP complex, and inactivated by GTPase-activating protein (GAP) GYP3.
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Golgi apparatus membrane
messages: Interacts with YIF1, YIP3, YIP4 and YIP5. Interacts with the GEF SEC2. Interacts with TRS130.
messages: Present with 4298 molecules/cell in log phase SD medium.
messages: Required for protein transport through the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Mediates the proper polarized localization of SEC2, a GEF for SEC4, but does not alter the exchange activity of SEC2 on SEC4. Plays a role in autophagy.

559292:YOL001W
gene id: 559292:YOL001W
uniprot id: P20052
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. PHO80 subfamily.
messages: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Negatively regulates the expression of phosphate-starvation-responsive genes under phosphate-rich conditions. The PHO80-PHO85 cyclin-CDK holoenzyme phosphorylates and inactivates the transcription factor PHO4, by preventing its association with the transcription factor PHO2 and the nuclear import receptor PSE1, and by promoting association with the nuclear export receptor MSN5, excluding PHO4 from the nucleus. PHO80-PHO85 phosphorylates and inactivates protein kinase RIM15 by retaining it in the cytoplasm, antagonizing RIM15-induced entry into stationary phase. PHO80-PHO85 also phosphorylates and inactivates the calcineurin-responsive transcription factor CRZ1, linking PHO85 to calcium signaling.
messages: Cytoplasm
messages: Forms a cyclin-CDK complex with PHO85. PHO80-PHO85 forms a stable complex with its inhibitor PHO81 under both high- and low-phosphate conditions, but PHO81 only inhibits the kinase upon phosphate starvation. Interacts with transcription factor PHO4.
messages: Inhibited by the CDK inhibitor (CKI) PHO81 in response to phosphate starvation.
messages: Nucleus
messages: Phosphorylation of Ser-267 by PHO85 is required to form an active cyclin-kinase complex and for function.

559292:YLL005C
gene id: 559292:YLL005C
uniprot id: Q07798
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an osmosensitive calcium-permeable cation channel (By similarity). Required for spore wall assembly and ascus formation.
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

559292:YJR047C
gene id: 559292:YJR047C
uniprot id: P19211
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Expressed in anaerobic conditions. Down-regulated by heme and the ROX1 and REO1 transcription factors in aerobic conditions.
messages: Homodimer. Interacts with DYS1 and LIA1.
messages: Lys-51 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
messages: Present with 14200 molecules/cell in log phase SD medium.
messages: There are two genes for eIF-5A in yeast.
messages: Was originally thought to be a translation initiation factor but further analysis (PubMed:19424157 and PubMed:19338753) clearly suggests that it is involved in translation elongation and not translation initiation.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Essential for polarized growth, a process necessary for G1/S transition. May mediate large range of effects of the polyamine spermidine in the cell (By similarity).

559292:YBR117C
gene id: 559292:YBR117C
uniprot id: P33315
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YPL282C
gene id: 559292:YPL282C
uniprot id: P0CE86
uniprot id: P0CE87
names: Miscellaneous
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Produced by alternative initiation at Met-41 of isoform 1. Major isoform.

559292:YNL040W
gene id: 559292:YNL040W
uniprot id: P53960
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Conflicting data shows that it is not able to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala) in trans (PubMed:14663147). Another paper shows that this protein can edit mischarged Ser-tRNA(Ala) but not Gly-tRNA(Ala) in trans (PubMed:20010690). Experiments are not well detailed in either paper.
messages: May function in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YCL035C
gene id: 559292:YCL035C
uniprot id: P25373
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutaredoxin family.
messages: Component of the glutathione system which performs several activities such as glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity (PubMed:11875065, PubMed:12684511). The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. GRX1 is less active as an oxidoreductase than GRX2 (PubMed:9571241, PubMed:18992757, PubMed:20417731).
messages: Cytoplasm
messages: In response to heat shock and osmotic stress.
messages: Nucleus
messages: Present with 3030 molecules/cell in log phase SD medium.

559292:YLR397C
gene id: 559292:YLR397C
uniprot id: P32794
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (PubMed:12006565, PubMed:17646390, PubMed:23185031, PubMed:24371142). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RLP24 from the pre-ribosomal particles (PubMed:17646390, PubMed:23185031, PubMed:24371142). This step facilitates the subsequent release of other shuttling proteins such as NOG1 and allows the transition of the pre-ribosomal particles to later maturation forms that bind REI1 (PubMed:17646390, PubMed:23185031, PubMed:24371142). Essential for viability (PubMed:8109176, PubMed:24371142).
messages: Belongs to the AAA ATPase family. AFG2 subfamily.
messages: Cytoplasm
messages: Homohexamer; ATP binding induces oligomerization (PubMed:12006565, PubMed:23185031). Forms a ring-shaped particle of about 12 nm diameter, that displays 6-fold radial symmetry (PubMed:12006565). Associates with cytoplasmic pre-60S ribosomal particles containing ARX1, ALB1, RLP24 and NOG1 (PubMed:17646390). Binds to pre-60S ribosomal particles soon after their export from the nucleus and is released before REI1 and LSG1 are incorporated into the particles (PubMed:17646390). Hexameric form interacts with RLP24 (via C-terminal); the interaction recruits AFG2 to pre-60S ribosomal particles and promotes AFG2 ATPase activity and RLP24 release from pre-60S ribosomal particles (PubMed:23185031, PubMed:24371142). Interacts (via N-terminus) with nucleoporin NUP116 (via N-terminus); the interaction is required for RLP24 release from pre-60S ribosomal particles (PubMed:23185031).
messages: Present with 799 molecules/cell in log phase SD medium.
messages: The first ATP-binding region binds ATP with low affinity whereas the second ATP-binding region binds ATP with high affinity (PubMed:12006565). ATP hydrolysis mediated by the second ATP binding region releases RLP24 from pre-60S ribosomal particles whereas the ATP hydrolysis mediated by the first ATP binding region is subsequently required for RLP24 dissociation from AFG2, probably by disassembling AFG2 into monomers (PubMed:23185031, PubMed:24371142).
messages: The hexamer is activated by RLP24 during pre-60S ribosomal particle maturation; RLP24 activates ATPase activity of both ATP-binding regions and increases cooperativity between AFG2 subunits (PubMed:23185031). The second ATP-binding region is inhibited by diazaborine; the inhibition requires prior ATP binding specifically to the second ATP-binding region (PubMed:24371142).

559292:YML023C
gene id: 559292:YML023C
uniprot id: Q03718
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Chromosome
messages: Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6. Interacts with KRE29.
messages: Nucleus
messages: Present with 907 molecules/cell in log phase SD medium.

559292:YKL001C
gene id: 559292:YKL001C
uniprot id: Q02196
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.
messages: Present with 2170 molecules/cell in log phase SD medium.

559292:YJL063C
gene id: 559292:YJL063C
uniprot id: P22353
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although this protein has evidently no mitochondrial targeting pre-sequence, it is efficiently transported into mitochondria.
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 3000 molecules/cell in log phase SD medium.

559292:YML028W
gene id: 559292:YML028W
uniprot id: P34760
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation (PubMed:8041739). Interacts with YAP1 via transient disulfide linkages (PubMed:19106090).
messages: Present with 378000 molecules/cell in log phase SD medium.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRX1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (PubMed:2895105, PubMed:7961686, PubMed:10681558, PubMed:15210711, PubMed:19106090). Protects the cell against the oxidative stress caused by nascent-protein misfolding and aggregation (PubMed:24424024). Relays hydrogen peroxide as a signal to the transcription factor YAP1 by inducing the formation of intramolecular disulfide bonds in YAP1, which causes its nuclear accumulation and activation (PubMed:15706081, PubMed:19106090). Can act alternatively as peroxidase and molecular chaperone. Oxidative stress and heat shock exposure cause a reversible shift of the protein structure from low MW species to high MW complexes, triggering a peroxidase-to-chaperone functional switch. The chaperone function of the protein enhances resistance to heat shock (PubMed:15163410).

559292:YDR079W
gene id: 559292:YDR079W
uniprot id: P38958
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET100 family.
messages: Mitochondrion membrane
messages: Present with 468 molecules/cell in log phase SD medium.
messages: Required for the biogenesis of cytochrome c oxidase. Probably for its assembly into an active holoenzyme.

559292:YLR089C
gene id: 559292:YLR089C
uniprot id: P52893
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.
messages: Mitochondrion matrix
messages: Present with 9960 molecules/cell in log phase SD medium.

559292:YJR106W
gene id: 559292:YJR106W
uniprot id: P47144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

559292:YDR243C
gene id: 559292:YDR243C
uniprot id: P23394
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.
messages: Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
messages: Component of the U5 snRNP complex, composed of at least BRR2, PRP8, PRP28, DIB1, LIN1, SMB1, SMD1, SMD2, SMD3, SME1, SMX2, SMX3, and SNU114, associated with the U5 snRNA.
messages: Cytoplasm
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

559292:YDR466W
gene id: 559292:YDR466W
uniprot id: Q03306
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Serine/threonine-protein kinase which may phosphorylate the same targets substrates as PKH1 and PKH2, 2 upstream activators of PKC1.

559292:YCR057C
gene id: 559292:YCR057C
uniprot id: P25635
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PWP2 family.
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Present with 16700 molecules/cell in log phase SD medium.
messages: Required for bud-site selection and cell separation. Also involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

559292:YHR039C-A
gene id: 559292:YHR039C-A
uniprot id: P48836
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Present with 2280 molecules/cell in log phase SD medium.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:7775427). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:7775427).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

559292:YLR377C
gene id: 559292:YLR377C
uniprot id: P09201
names: Activity Regulation
names: Cofactor
names: Domain
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Homotetramer.
messages: Present with 589 molecules/cell in log phase SD medium.
messages: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. AMP binding affects the turnover of bound substrate and not the affinity for substrate (By similarity).
messages: The Pro/N-degron targets the protein for proteasomal degradation when cells are shifted to glucose-containing growth medium.
messages: Ubiquitinated (PubMed:22645139). Targeted for proteasomal degradation when cells are shifted to glucose-containing growth medium (PubMed:12686616, PubMed:18508925, PubMed:22645139, PubMed:28126757).

559292:YMR280C
gene id: 559292:YMR280C
uniprot id: P39113
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Activator of the gluconeogenic enzymes FBP1 and PCK1 genes.
messages: Could be the target of the SNF1/CAT1 - SNF4/CAT3 kinase complex.
messages: Nucleus

559292:YCR102C
gene id: 559292:YCR102C
uniprot id: P25608
names: Similarity
messages: Belongs to the YCR102c/YLR460c/YNL134c family.

559292:YJR035W
gene id: 559292:YJR035W
uniprot id: P40352
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: May be involved in the preferential repair of active genes.
messages: Nucleus

559292:YDL169C
gene id: 559292:YDL169C
uniprot id: P32772
names: Induction
messages: In carbon, ammonium, phosphate and sulfate starvation conditions.

559292:YPR158W
gene id: 559292:YPR158W
uniprot id: Q06469
names: Function
names: Subcellular Location Annotation
messages: Involved in the curing of prion [URE3]. Nuclear localization of this protein may suggest a role in transcription regulation, so it might exert an effect on [URE3] through known prion-curing chaperones or BTN2.
messages: Nucleus

559292:YLR118C
gene id: 559292:YLR118C
uniprot id: Q12354
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
messages: Cytoplasm
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
messages: Nucleus
messages: Present with 1480 molecules/cell in log phase SD medium.

559292:YOR347C
gene id: 559292:YOR347C
uniprot id: P52489
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.
messages: May be used by cells under conditions in which the level of glycolytic flux is very low.
messages: Not activated by fructose-1,6-bisphosphate.
messages: Present with 2130 molecules/cell in log phase SD medium.

559292:YDL157C
gene id: 559292:YDL157C
uniprot id: Q12082
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Present with 752 molecules/cell in log phase SD medium.
messages: To S.pombe tam6.

559292:YKL003C
gene id: 559292:YKL003C
uniprot id: P28778
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion

559292:YKL057C
gene id: 559292:YKL057C
uniprot id: P35729
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP120 is part of the heptameric 0.5 MDa autoassembling NUP84 NPC subcomplex (NUP84, NUP85, NUP120, NUP133, NUP145C, SEC13 and SEH1).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP120 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.
messages: Nucleus membrane
messages: nuclear pore complex

559292:YER106W
gene id: 559292:YER106W
uniprot id: P40065
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore during late pachytene.
messages: Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis.
messages: Nucleus
messages: Phosphorylated by CDC5. This phosphorylation is required for the location to the kinetochores during late pachytene.

559292:YHR157W
gene id: 559292:YHR157W
uniprot id: P33323
names: Developmental Stage
names: Function
names: Subunit
messages: Interacts with REC114 and SPO11.
messages: Meiosis-specific.
messages: Potential transcriptional regulator that is required to activate expression of a number of early meiotic genes including HOP1.

559292:YDR071C
gene id: 559292:YDR071C
uniprot id: Q12447
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates spermine and probably also other polyamines such as putrescine or spermidine. May regulate the levels of polyamines on chromosomal DNA, which would modify chromatin structure and affect transcription or replication. Also able to acetylate arylalkylamines such as tryptamine and serotonin in vitro.
messages: Belongs to the acetyltransferase family. AANAT subfamily.
messages: Cytoplasm
messages: Present with 8680 molecules/cell in log phase SD medium.

559292:YLR145W
gene id: 559292:YLR145W
uniprot id: Q12530
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of RNase MRP complex which consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Cytoplasm
messages: Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria.
messages: Membrane
messages: Nucleus
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YMR112C
gene id: 559292:YMR112C
uniprot id: Q99278
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex (PIC) with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The essential MED11/22 heterodimer specifically functions in promoting stable PIC formation.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. MED11 forms a heterodimer with SRB6/MED22. The MED11/22 heterodimer binds to and stabilizes the central head subunit SRB4/MED17. Interacts with TFIIH subunit RAD3.
messages: Nucleus
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YER126C
gene id: 559292:YER126C
uniprot id: P40078
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats) (PubMed:25404745).
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles. Under normal, rapid growth conditions, high levels of NSA2 would allow the progression of pre-60S particles through the ITS2 processing.
messages: Present with 8660 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YER187W
gene id: 559292:YER187W
uniprot id: P40102
names: Similarity
messages: To yeast killer toxin KHS and to YGL262w.

559292:YLR179C
gene id: 559292:YLR179C
uniprot id: Q06252
names: Miscellaneous
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.
messages: Present with 6230 molecules/cell in log phase SD medium.

559292:YDL081C
gene id: 559292:YDL081C
uniprot id: P05318
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A (PubMed:16573688, PubMed:11431471).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: The 4 small acidic ribosomal P-proteins from yeast can be classified into two couples of similar but not identical sequences. Each couple (P1A/P1B and P2A/P2B) is distinctly related to one of the two acidic ribosomal P-proteins P1/P2 present in multicellular organisms.

559292:YER159C-A
gene id: 559292:YER159C-A
uniprot id: P0CX65
uniprot id: P0CX66
uniprot id: P0CX67
uniprot id: P0CX68
uniprot id: P0CX69
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR5 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ER2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-GR3 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-MR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YBR159W
gene id: 559292:YBR159W
uniprot id: P38286
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
messages: Endoplasmic reticulum membrane
messages: Interacts with the fatty acid elongation system components ELO3 and TSC13.
messages: Present with 41900 molecules/cell in log phase SD medium.

559292:YDR483W
gene id: 559292:YDR483W
uniprot id: P27809
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Golgi apparatus membrane
messages: Mannosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Required for the attachment of the third mannose residue of O-linked saccharides.
messages: Present with 13000 molecules/cell in log phase SD medium.

559292:YMR142C
gene id: 559292:YMR142C
uniprot id: P40212
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL13 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 54200 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL13 in yeast.

559292:YML111W
gene id: 559292:YML111W
uniprot id: Q03758
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUL1 family.
messages: Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1. The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2.
messages: Component of the RSP5-BUL1/2 ubiquitin ligase complex composed of at least RSP5 and BUL1 or BUL2.
messages: Cytoplasm
messages: Present with 339 molecules/cell in log phase SD medium.
messages: The PY-motif is required for the interaction with RSP5 ubiquitin-ligase and the HSE-mediated gene expression.

559292:YNL084C
gene id: 559292:YNL084C
uniprot id: P39013
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the END3 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex composed of at least END3, PAN1, and SLA1. Interacts with SCD5, SLA2 and YAP1802. Interacts directly with PAN1; the interaction with PAN1 is prevented by PAN1 phosphorylation by PKR1.
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. END3 regulates PAN1 function by preventing phosphorylation of PAN1 by PKR1 and is also involved in the correct localization of SLA1 to the cell cortex, in the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface.
messages: Endosome membrane
messages: Present with 2610 molecules/cell in log phase SD medium.
messages: actin patch

559292:YMR048W
gene id: 559292:YMR048W
uniprot id: Q04659
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.
messages: Forms a fork protection complex (FPC) with TOF1 which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors and protects stalled replication forks against the fork-releasing activity of RRM3 helicase.
messages: Nucleus
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YJL101C
gene id: 559292:YJL101C
uniprot id: P32477
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.
messages: Catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine (gamma-GC), the first and rate-limiting step in the production of glutathione (GSH).
messages: Feedback inhibition by glutathione.
messages: Present with 5130 molecules/cell in log phase SD medium.

559292:YOR285W
gene id: 559292:YOR285W
uniprot id: Q12305
names: Activity Regulation
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: GSS(-) is a potent inhibitor of RDL1, since the presence of the sulfur dioxygenase strongly increases the RDL1 catalytic activity (PubMed:24981631).
messages: Mitochondrion
messages: Present with 7470 molecules/cell in log phase SD medium.
messages: Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).

559292:YMR146C
gene id: 559292:YMR146C
uniprot id: P40217
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Present with 2400 molecules/cell in log phase SD medium.
messages: The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.

559292:YHR055C
gene id: 559292:YHR055C
uniprot id: P0CX80
uniprot id: P0CX81
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 12 family.
messages: Contains 1 metal-binding domain: 6 to 8 copper ions are chelated within a single copper-thiolate cluster and are coordinated via cysteinyl thiolate bridges to 10 cysteine ligands. 6 copper ions are trigonally coordinated, whereas the other 2 are only digonally coordinated.
messages: Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins.
messages: There are 2 copies for copper thionein in yeast. The 2 identical copies CUP1-1 and CUP1-2 are arranged in tandem.

559292:YLR174W
gene id: 559292:YLR174W
uniprot id: P41939
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: By catabolite repression.
messages: Cytoplasm
messages: Homodimer.
messages: May function in the production of NADPH for fatty acid and sterol synthesis.
messages: Present with 2620 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YDR496C
gene id: 559292:YDR496C
uniprot id: Q04373
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PUF6 family.
messages: Bud tip
messages: Component of the ASH1 mRNP composed of at least PUF6, SHE2, SHE3, SHE1 and the ASH1 mRNA. Interacts with SHE2 and FUN12.
messages: Present with 21500 molecules/cell in log phase SD medium.
messages: RNA-binding protein involved in post-transcriptional regulation. Component of the ASH1 mRNP which transports the ASH1 mRNA to the distal tip of the bud, where the ASH1 protein is translated and targeted to the daughter cell nucleus. Binds to the ASH1 3'-UTR containing the PUF consensus UUGU segment and represses its translation. This silencing of ASH1 mRNA is critical for asymmetric seggregation of ASH1 to the daughter cell nucleus.
messages: nucleolus
messages: phosphorylation by CK2 relieves translational repression activity.

559292:YDL178W
gene id: 559292:YDL178W
uniprot id: P46681
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate. Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate (PubMed:26774271). In addition to its enzymatic role it could play an important role in the yeast cell morphology (PubMed:10509019).
messages: Interacts with F-actin.
messages: Mitochondrion matrix
messages: Present with 11400 molecules/cell in log phase SD medium.

559292:YLR166C
gene id: 559292:YLR166C
uniprot id: Q06245
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Present with 2340 molecules/cell in log phase SD medium.
messages: The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

559292:YPL138C
gene id: 559292:YPL138C
uniprot id: Q03012
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the COMPASS (Set1C) complex which consists of SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and SWD3(1).
messages: Nucleus
messages: Present with 1680 molecules/cell in log phase SD medium.
messages: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.

559292:YJR008W
gene id: 559292:YJR008W
uniprot id: P47085
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MEMO1 family.
messages: Cytoplasm
messages: Expression is induced by mild heat-stress on a non-fermentable carbon source (PubMed:14561723). Expression is also induced upon entry into stationary phase and upon nitrogen deprivation (PubMed:11102521). Expression is repressed by inosine and choline in an OPI1-dependent manner (PubMed:12871953).
messages: Is synthetic lethal with PLC1.
messages: Nucleus
messages: Plays a role in haploid invasive growth under conditions of nutrient insufficiency, suggesting that the function of the MEMO1 family in cell motility/invasion is conserved across species.
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YKL080W
gene id: 559292:YKL080W
uniprot id: P31412
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Present with 21114 molecules/cell in log phase SD medium.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:10781598, PubMed:11777935, PubMed:1730668, PubMed:8416931). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:8416931). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (PubMed:15792803). Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section (PubMed:15792803).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:25971514). Interacts directly with VMA4 (PubMed:15751969).
messages: Vacuole membrane

559292:YCR086W
gene id: 559292:YCR086W
uniprot id: P25651
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore. Interacts with CDC46, CDC47, GIC1, GIC2, MCM3 and NUR1.
messages: Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Also plays a mitotic role in DNA replication.
messages: Present with 1920 molecules/cell in log phase SD medium.
messages: centromere
messages: nucleolus

559292:YLR150W
gene id: 559292:YLR150W
uniprot id: P39015
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds specifically G4 quadruplex (these are four-stranded right-handed helices, stabilized by guanine base quartets) and purine motif triplex (characterized by a third, antiparallel purine-rich DNA strand located within the major groove of a homopurine stretch of duplex DNA) nucleic acid structures. These structures may be present at telomeres or in rRNAs. Acts with CDC13 to control telomere length homeostasis. Involved in the control of the apoptosis-like cell death.
messages: Cytoplasm
messages: Interacts with CDC13. Associates with mature 80S ribosomes. Associates with the telomere-proximal Y' element.
messages: Nucleus
messages: Present with 46842 molecules/cell in log phase SD medium.
messages: perinuclear region

559292:YBL086C
gene id: 559292:YBL086C
uniprot id: P38177
names: Miscellaneous
names: Similarity
messages: Present with 396 molecules/cell in log phase SD medium.
messages: To S.pombe SpCC1494.08c.

559292:YOR271C
gene id: 559292:YOR271C
uniprot id: Q12029
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria.
messages: Mitochondrion membrane
messages: Present with 9290 molecules/cell in log phase SD medium.

559292:YNL290W
gene id: 559292:YNL290W
uniprot id: P38629
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair. RFC3 supplies a catalytic site to the ATP site of RFC4.
messages: Nucleus
messages: Present with 3140 molecules/cell in log phase SD medium.
messages: Replication factor C (RFC) is a heteropentamer of subunits RFC1, RFC2, RFC3, RFC4 and RFC5 and forms a complex with POL30/PCNA in the presence of ATP. Component of the RAD24-RFC complex which consists of RAD14, RFC2, RFC3, RFC4 and RFC5 and associates with the checkpoint clamp DDC1:MEC3:RAD17 complex. Component of the ELG1-RFC complex which consists of ELG1, RFC2, RFC3, RFC4 and RFC5. Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. RFC3 interacts with ECO1 and POL30/PCNA.

559292:YBR140C
gene id: 559292:YBR140C
uniprot id: P18963
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibitory regulator of the Ras-cyclic AMP pathway in S.cerevisiae. Stimulates the GTPase activity of Ras proteins.

559292:YML099C
gene id: 559292:YML099C
uniprot id: P05085
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ARG80 and MCM1.
messages: Nucleus
messages: With ARG80, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.

559292:YMR195W
gene id: 559292:YMR195W
uniprot id: Q04329
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Induced by amino acids starvation.
messages: Invasive growth defect with elongated cell morphology.
messages: Present with 4050 molecules/cell in log phase SD medium.
messages: Required for viability of cells lacking mtDNA.
messages: Vacuole membrane

559292:YBR082C
gene id: 559292:YBR082C
uniprot id: P15731
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: By heat shock and cadmium.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:17550898). Mediates the selective degradation of short-lived and abnormal proteins (PubMed:17550898). Mediates ubiquitination of PEX5 (PubMed:17550898).
messages: Defective activation of the ribosome quality control (RQC) pathway.
messages: Interacts with TUL1.
messages: Present with 13500 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YDR237W
gene id: 559292:YDR237W
uniprot id: P36519
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. Unlike bacterial L5, uL5m does not bind zinc.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

559292:YDL037C
gene id: 559292:YDL037C
uniprot id: Q12140
names: Miscellaneous
messages: Open reading frame exhibits genomic organization compatible with a translational readthrough-dependent mode of expression.

559292:YER022W
gene id: 559292:YER022W
uniprot id: P32569
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. The head module may also interact with the TFIIF complex. SRB4/MED17 interacts directly with MED6, MED11, ROX3/MED19, SRB2/MED20 and SRB6/MED22. Interacts directly with the activator GAL4.
messages: Nucleus
messages: Present with 1720 molecules/cell in log phase SD medium.

559292:YDR025W
gene id: 559292:YDR025W
uniprot id: P0CX47
uniprot id: P0CX48
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS17 in yeast.

559292:YNL054W
gene id: 559292:YNL054W
uniprot id: P53950
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold.
messages: N-glycosylated.
messages: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Positively regulates FAB1 kinase activity. Major activator of FAB1 during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of VAC14 and FIG4. Directly involved in vacuolar membrane scission. Required for normal vacuole acidification, inheritance and morphology.
messages: Vacuole membrane

559292:YDL130W-A
gene id: 559292:YDL130W-A
uniprot id: P01098
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Mitochondrion
messages: This is 1 of 2 proteins that can stabilize the ATPase-inhibitor complex, which normally dissociates when externally added ATP has been consumed.

559292:YLL041C
gene id: 559292:YLL041C
uniprot id: P21801
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Mitochondrion inner membrane
messages: Present with 9540 molecules/cell in log phase SD medium.
messages: Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.

559292:YLR432W
gene id: 559292:YLR432W
uniprot id: P50095
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Present with 26300 molecules/cell in log phase SD medium.

559292:YHR132W-A
gene id: 559292:YHR132W-A
uniprot id: Q9P305
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by RIM15.
messages: Present with 1400 molecules/cell in log phase SD medium.
messages: Required for TORC1 to properly control gene expression and chronological life span. Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

559292:YDR261W-B
gene id: 559292:YDR261W-B
uniprot id: Q07791
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YDR261W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YGR078C
gene id: 559292:YGR078C
uniprot id: P48363
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Present with 6550 molecules/cell in log phase SD medium.

559292:YDL117W
gene id: 559292:YDL117W
uniprot id: Q07533
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYK3 family.
messages: Bud neck
messages: Cytoplasm
messages: Interacts with INN1.
messages: Involved in cytokinesis by recruiting INN1 to the bud neck. Cooperates with INN1 to stimulate the synthesis of the primary septum (PS) by CHS2.
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YML133C
gene id: 559292:YML133C
uniprot id: Q03099
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YLR270W
gene id: 559292:YLR270W
uniprot id: Q06151
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: By nutrient, osmotic, oxidative and heat stress. Up-regulated during the diauxic shift.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP) or tri-methyl guanosine nucleoside monophosphate (m3(2,2,7)GMP), respectively. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to (m(7)GMP) and m3(2,2,7)GMP, respectively (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCS1 to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. May also regulate the 5'->3' exoribonucleolytic mRNA decay pathway in a cap-independent manner. Negatively regulates trehalase activity.
messages: Homodimer. Forms heterodimer with DCS2; the interaction inhibits the DCS1 scavenger decapping activity during post-diauxic growth.
messages: P-body
messages: Phosphorylated. Phosphorylation occurs upon glucose deprivation.
messages: Present with 9920 molecules/cell in log phase SD medium.
messages: The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity.
messages: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro.
messages: perinuclear region

559292:YIL016W
gene id: 559292:YIL016W
uniprot id: P40548
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with the HSP70 family members SSA1, SSA4, and SSB1. These interactions are strongly reduced by ADP and ATP.
messages: Nucleus membrane
messages: Present with 3346 molecules/cell in log phase SD medium.
messages: Stimulator of ATPase activity of molecular chaperones of the HSP70 family (principally of the SSA class). Stimulation is important for HSP70-substrate complex dissociation after folding of newly synthesized or refolded proteins. SNL1 is probably involved in nuclear pore biogenesis and in particular the folding or refolding of misfolded NUP116, GLE2 and NIC96.

559292:YBR155W
gene id: 559292:YBR155W
uniprot id: P33313
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TTC4 family.
messages: Co-chaperone that binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. Involved in only a subset of Hsp90 functions.
messages: Cytoplasm
messages: Monomer. Component of Hsp70 and Hsp90 chaperone complexes. Interacts (via TPR repeats) with HSC82 and HSP82 (via C-terminal MEEVD pentapeptide). Interacts with CPR7, SSA1 and SPI1.
messages: Not induced by heat shock.
messages: Present with 672 molecules/cell in log phase SD medium.

559292:YPL024W
gene id: 559292:YPL024W
uniprot id: Q02685
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMI1 family.
messages: Cytoplasm
messages: Forms a complex with SGS1 and TOP3.
messages: Nucleus
messages: Present with 1500 molecules/cell in log phase SD medium.
messages: Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with SGS1 and TOP3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response. Required for resistance to the DNA-damaging agent methyl methanesulfonate (MMS).

559292:YNR041C
gene id: 559292:YNR041C
uniprot id: P32378
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

559292:YNL206C
gene id: 559292:YNL206C
uniprot id: P40161
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RTT106 family.
messages: Chromosome
messages: Decreases nucleosomal density (PubMed:25406467, PubMed:19683497). Increases HTA1 RNA level; simultaneous disruption RTT109 alleviates the effect (PubMed:22156209, PubMed:19683497).
messages: Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by directly recruiting the SWI/SNF and RSC chromatin remodeling complexes to the histone genes in a cell cycle dependent manner. In cooperation with HIR and ASF1, creates a repressive structure at the core histone gene promoter and contributes to their repression outside of S phase. Involved in regulation of Ty1 transposition.
messages: Homodimers (via the N-terminal domain) (PubMed:22307274). Interacts with the SWI/SNF complex (PubMed:21698254). Interacts with the RSC complex (PubMed:21698254). Interacts with the HIR complex (PubMed:21698254, PubMed:19683497). Interacts with the CAF-1 complex (PubMed:19683497). Interacts with RLF2 (PubMed:16157874). Interacts with SIR4 (PubMed:17410207). Interacts with YTA7 (PubMed:22156209). Interacts with CAC2 (PubMed:19683497). Interacts with HPC2 (PubMed:19683497). Interacts with HIR2 (PubMed:19683497). Interacts with MSI1 (PubMed:19683497). Interacts with HIR1 (PubMed:19683497). Interacts with histone H3 (PubMed:16157874, PubMed:20007951, PubMed:20188666, PubMed:21444721, PubMed:22307274). Interacts with histone H4 (PubMed:16157874, PubMed:20007951, PubMed:21444721, PubMed:22307274).
messages: Nucleus
messages: Present with 11100 molecules/cell in log phase SD medium.
messages: The N-ter domain (residues 1-67) homodimerizes and interacts with H3-H4 independently of acetylation while the double pleckstrin-homology (PH) domain (residues 68-301) binds the 'Lys-56'-containing region of H3.

559292:YDL211C
gene id: 559292:YDL211C
uniprot id: Q12121
names: Miscellaneous
names: Subcellular Location Annotation
messages: Present with 3360 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YDL147W
gene id: 559292:YDL147W
uniprot id: Q12250
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit p55 family.
messages: N-acetylated by NAT1.
messages: Present with 5710 molecules/cell in log phase SD medium.

559292:YMR266W
gene id: 559292:YMR266W
uniprot id: Q03516
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an osmosensitive calcium-permeable cation channel.
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

559292:YKL141W
gene id: 559292:YKL141W
uniprot id: P33421
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of two integral membrane proteins.
messages: Membrane-anchoring mono-heme cytochrome b subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH3 and SDH4 form the membrane dimer that anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction.
messages: Mitochondrion inner membrane
messages: Present with 238 molecules/cell in log phase SD medium.
messages: The heme is bound between the two transmembrane subunits.

559292:YKL086W
gene id: 559292:YKL086W
uniprot id: P36077
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfiredoxin family.
messages: By hydrogen peroxide.
messages: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase.
messages: Cytoplasm
messages: Forms a transient disulfide bond with TSA1 during the reduction of cysteine sulfinic acid (-SO2H).
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YDR439W
gene id: 559292:YDR439W
uniprot id: Q04087
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore.
messages: Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.
messages: Phosphorylated by CDC5. This phosphorylation is required for the location to the kinetochores during late pachytene.
messages: Present with 1390 molecules/cell in log phase SD medium.
messages: centromere
messages: nucleolus

559292:YPL280W
gene id: 559292:YPL280W
uniprot id: Q08992
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C56 family. HSP31-like subfamily.
messages: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893).
messages: Homodimer.
messages: Induced during entry into stationary phase.
messages: P-body
messages: Results in higher sensitivity to oxidative stress, reduced thermotolerance, accumulation of higher levels of reactive oxygen species, and reduced chronological life span.

559292:YPL258C
gene id: 559292:YPL258C
uniprot id: Q08975
names: Function
names: Induction
names: Similarity
messages: By absence of thiamine.
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probably that of HMP to HMP-P.
messages: In the C-terminal section; belongs to the thiaminase-2 family.
messages: In the N-terminal section; belongs to the ThiD family.

559292:YIL156W
gene id: 559292:YIL156W
uniprot id: P40453
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Involved in the sorting of ubiquitinated cargo proteins at the multivesicular body (MVB).
messages: Present with 606 molecules/cell in log phase SD medium.

559292:YNR030W
gene id: 559292:YNR030W
uniprot id: P53730
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Present with 3550 molecules/cell in log phase SD medium.

559292:YPR029C
gene id: 559292:YPR029C
uniprot id: Q12028
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1) (PubMed:10564262). AP-1 interacts with clathrin (PubMed:10564262). Also a component of the AP-1R complex composed of at least APM2, APL4 and APS1 (PubMed:26658609).
messages: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles (PubMed:10564262). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (PubMed:10564262). The AP-1 complex interacts directly with clathrin (PubMed:10564262). Component of the AP-1-related (AP-1R) complex, an adapter protein complex that mediates sorting of cargo SNARE SNC1 (PubMed:26658609). In contrast to the APM1-containing AP-1 complex, AP-1R is incapable of sorting CHS3 (PubMed:26658609).
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Present with 4850 molecules/cell in log phase SD medium.
messages: clathrin-coated vesicle membrane

559292:YGL195W
gene id: 559292:YGL195W
uniprot id: P33892
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a positive activator of the GCN2 protein kinase activity in response to low amino acid, carbon, or purine availability (PubMed:8497269, PubMed:24333428. PubMed:10733573). Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity (PubMed:7621831, PubMed:9234705, PubMed:15722345). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator GCN4, by promoting the GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) on 'Ser-52', and hence allowing GCN4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:8497269, PubMed:10801780, PubMed:11350982, PubMed:15722345).
messages: Belongs to the GCN1 family.
messages: Cytoplasm
messages: Inhibits GCN4 derepression in glucose, amino acid, or purine-starved cells.
messages: Interacts (via N- and C-terminus) with GCN2 (via N-terminal RWD domain); this interaction stimulates GCN2 kinase activity in a GCN20-dependent manner in response to amino acid starvation (PubMed:10775272, PubMed:11101534, PubMed:10801780, PubMed:11350982, PubMed:15126500, PubMed:15722345, PubMed:21849502). Interacts (via C-terminus) with GCN20 (via N-terminus); this interaction stimulates GCN2 kinase activity in response to amino acid starvation (PubMed:7621831, PubMed:9234705, PubMed:11101534). The GCN1-GCN20 complex interacts with GCN2 on translating ribosomes in amino acid-starved cells; GCN1 may bind near the ribosomal A-site and promotes the transfer of uncharged tRNAs from the A-site to the tRNA-binding domain in GCN2 for its subsequent kinase activation, and hence allowing GCN4 translational activation and derepression of amino acid biosynthetic genes (PubMed:7621831, PubMed:9234705, PubMed:10775272, PubMed:11101534). Interacts (via C-terminus) with YIH1 (via N-terminus); this interaction reduces the GCN1-GCN20 complex formation and prevents the interaction of GCN1 with GCN2 and GCN2 kinase activation in amino acid-starved cells (PubMed:15126500, PubMed:21239490, PubMed:22404850). Interacts with GIR2; this interaction prevents the interaction of GCN1 with GCN2 and GCN2 kinase activation in amino acid-starved cells (PubMed:19448108). Interacts (via middle region) with RPS10A and RPS10B; these interactions are direct and promote GCN2 kinase activation (PubMed:25437641). Associates (via N-terminus) with ribosomes; this association is stimulated in a ATP- and GCN20-dependent manner and is necessary to activate GCN2 kinase activity (PubMed:7621831, PubMed:9234705, PubMed:11101534, PubMed:15722345, PubMed:19448108, PubMed:21849502, PubMed:22888004, PubMed:25437641).
messages: Present with 7330 molecules/cell in log phase SD medium.
messages: The EF3-like region is necessary and sufficient for interaction with GCN20 (PubMed:9234705).

559292:YPL175W
gene id: 559292:YPL175W
uniprot id: P32363
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1.
messages: Endoplasmic reticulum membrane
messages: Inhibited by Ras, probably via the interaction between RAS2 and ERI1.
messages: Present with 1480 molecules/cell in log phase SD medium.
messages: Was originally thought to be involved in transcription.

559292:YLR218C
gene id: 559292:YLR218C
uniprot id: Q05809
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA4 family.
messages: Involved in cytochrome c oxidase assembly or stability.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Present with 907 molecules/cell in log phase SD medium.
messages: The twin Cx9C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.

559292:YBR045C
gene id: 559292:YBR045C
uniprot id: P38229
names: Subunit
messages: Interacts with phosphatase 1 (GLC7).

559292:YIL130W
gene id: 559292:YIL130W
uniprot id: P40467
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASG1 family.
messages: No growth on non-fermentable carbon sources like glycerol and lactate and sensitivity to calcofluor white.
messages: Nucleus
messages: Present with 396 molecules/cell in log phase SD medium.
messages: Probable transcription factor involved in the stress response.

559292:YIL073C
gene id: 559292:YIL073C
uniprot id: P40511
names: Function
names: Similarity
messages: Belongs to the SPO22 family.
messages: Involved in chromosome segregation during sporulation.

559292:YJR117W
gene id: 559292:YJR117W
uniprot id: P47154
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Present with 19600 molecules/cell in log phase SD medium.
messages: Proteolytically removes the C-terminal three residues of farnesylated A-factor mating pheromone. Also acts to cleave the N-terminal extension of the pheromone. Does not act on Ras.

559292:YML012W
gene id: 559292:YML012W
uniprot id: P54837
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with EMP24, ERP1 and ERP2.
messages: Belongs to the EMP24/GP25L family.
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Possesses a C-terminal dilysine motif that interacts with COPI coat subunits. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Present with 51700 molecules/cell in log phase SD medium.

559292:YMR020W
gene id: 559292:YMR020W
uniprot id: P50264
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.
messages: Binds 1 FAD per subunit.
messages: Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance.
messages: Present with 6960 molecules/cell in log phase SD medium.

559292:YDL200C
gene id: 559292:YDL200C
uniprot id: P26188
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: In contrast to some bacterial and mammalian enzymes, MGT1 is not induced by alkylating agents.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Prefers double-stranded DNA over single-stranded DNA as substrate.
messages: Nucleus
messages: Present with 150 molecules/cell in log phase YPD medium, but not detectable in stationary phase cells.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

559292:YKR038C
gene id: 559292:YKR038C
uniprot id: P36132
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YMR179W
gene id: 559292:YMR179W
uniprot id: P35209
names: Function
messages: Required for normal transcription at a number of loci in yeast.

559292:Q0085
gene id: 559292:Q0085
uniprot id: P00854
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

559292:YDR165W
gene id: 559292:YDR165W
uniprot id: Q03774
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit TRM8.
messages: Nucleus
messages: Present with 5910 molecules/cell in log phase SD medium.
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

559292:YPL063W
gene id: 559292:YPL063W
uniprot id: Q02776
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts directly with TIM23. Interacts with preproteins in transit.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex. Does not act as a structural subunit of the TIM23 complex but plays a dynamic role in protein import. Has no phosphatase activity.
messages: Mitochondrion inner membrane
messages: Present with 2400 molecules/cell in log phase SD medium.
messages: The FCP1 homology domain does not contain the canonical D-x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity.
messages: The mitochondrial intermembrane region is required for generation but not stabilization of the TIM23 complex.

559292:YLR408C
gene id: 559292:YLR408C
uniprot id: Q06071
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
messages: Endosome
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YPL132W
gene id: 559292:YPL132W
uniprot id: P19516
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

559292:YPL158C
gene id: 559292:YPL158C
uniprot id: Q99299
names: Disruption Phenotype
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM44 family.
messages: Bud neck
messages: Expression is controlled by SWI5.
messages: Increases frequency of mitochondrial genome loss.
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YDR392W
gene id: 559292:YDR392W
uniprot id: P06844
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT3 family.
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. SPT3 interacts directly with TBP (TATA-binding protein). Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SPT3 is required for recruitment of TATA-binding protein (TBP) to SAGA-dependent promoters. During SAGA-mediated transcriptional inhibition, SPT3 and SPT8 prevent binding of TBP to the TATA box. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. SPT factors 3, 7 and 8 are required for the initiation of Ty transcription from the delta promoter. SPT3 regulates Ty1 as well as the mating factor genes.
messages: Nucleus
messages: Present with 1710 molecules/cell in log phase SD medium.

559292:YGR034W
gene id: 559292:YGR034W
uniprot id: P53221
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 33200 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL24 in yeast.

559292:YLR396C
gene id: 559292:YLR396C
uniprot id: P20795
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Component of the HOPS complex which is composed of PEP5, VPS16, PEP3, VPS33, VPS39 and VPS41. HOPS associates with phosphoinositides and the PX domain of VAM7. Interacts with IVY1 and VAM7.
messages: Essential for vacuolar biogenesis, maturation and function. Involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
messages: Present with 830 molecules/cell in log phase SD medium.
messages: Vacuole

559292:YLR164W
gene id: 559292:YLR164W
uniprot id: Q06236
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Does not affect SDH or TIM22 complex formation.
messages: Homolog of SDH4, but seems not to be a stoichiometric subunit of either the succinate dehydrogenase (SDH) complex or the mitochondrial inner membrane translocase TIM22 complex.
messages: Interacts with SDH3.
messages: Mitochondrion inner membrane

559292:YBR069C
gene id: 559292:YBR069C
uniprot id: P38085
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: High-affinity transport of valine and tyrosine. Low-affinity transport of tryptophan. Can also transport L-cysteine.
messages: Membrane
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YDL001W
gene id: 559292:YDL001W
uniprot id: Q03441
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMD1/sif2 family.
messages: Cytoplasm
messages: Present with 952 molecules/cell in log phase SD medium.
messages: Required for sporulation where it is believed to have a role in meiotic nuclear division.

559292:YNL092W
gene id: 559292:YNL092W
uniprot id: P53934
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.
messages: N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
messages: Present with 952 molecules/cell in log phase SD medium.

559292:YJR004C
gene id: 559292:YJR004C
uniprot id: P20840
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: By exposition to pheromone (A-factor) secreted by the opposite mating type cells (type A).
messages: Cell surface glycoprotein promoting cell-cell contact to facilitate mating. S.cerevisiae A and alpha cells express the complementary cell surface glycoproteins A-agglutinin and alpha-, respectively, which interact with one another to promote cellular aggregation during mating.
messages: Interacts with AGA2.
messages: Membrane
messages: N-glycosylated, and O-glycosylated by both PMT1 and PMT2.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: To C.albicans ALS1.
messages: cell wall

559292:YMR110C
gene id: 559292:YMR110C
uniprot id: Q04458
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). Involved in coenzyme Q (CoQ) biosynthesis, catalyzing the last step in the tyrosine to 4-hydroxybenzoate (4-HB) pathway. Oxidizes 4-hydroxybenzaldehyde (4-Hbz) to 4-HB, the aromatic precursor for coenzyme Q (PubMed:27693056, PubMed:27669165).
messages: Cytoplasmic granule membrane
messages: Endosome membrane
messages: Lipid droplet
messages: Mitochondrion outer membrane
messages: Present with 2930 molecules/cell in log phase SD medium.
messages: Results in coenzyme Q deficiency.

559292:YPL164C
gene id: 559292:YPL164C
uniprot id: Q12083
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Heterodimer of MLH1 and MLH3, called MutLbeta, which is involved in correction of a specific subset of IDLs when associated with MutSbeta. Forms a ternary complex with a SGS1-TOP3 heterodimer during meiosis.
messages: Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.
messages: Nucleus

559292:YDR226W
gene id: 559292:YDR226W
uniprot id: P07170
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: Present with 123000 molecules/cell in log phase SD medium.
messages: The phenotype of disruption mutants is pet, showing that complementation by another adenylate kinase isozyme occurs only under fermentative conditions. The disruption completely destroys the activity in mitochondria, whereas in the cytoplasmic fraction about 10% is retained.
messages: cytosol

559292:YOR322C
gene id: 559292:YOR322C
uniprot id: Q12502
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB19 family.
messages: Cytoplasm
messages: Expressed periodically during cell division with a peak during M phase.
messages: Golgi apparatus
messages: May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface. Involved in the resistance to EDTA, cadmium chloride, cycloheximide, 6-dimethylaminopurine, methyl caffeate, beta-chloro-L-alanine, caffeine and cerulenin.
messages: Present with 295 molecules/cell in log phase SD medium.

559292:YPL216W
gene id: 559292:YPL216W
uniprot id: Q08964
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: May be required for the activity of an ISWI chromatin-remodeling complex.
messages: Nucleus
messages: Present with 3060 molecules/cell in log phase SD medium.

559292:YGR178C
gene id: 559292:YGR178C
uniprot id: P53297
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal mRNA processing; 3' termini are cleaved but transcripts lack full-length poly(A) tails (PubMed:9819425). Decreases HO mRNA translation (PubMed:15082763).
messages: Belongs to the ataxin-2 family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with MKT1 (via C-terminus) (PubMed:15082763). Interacts with FIR1, IGO1, LSM12, PBP4 and PAB1 (PubMed:15121841, PubMed:16702403, PubMed:20471941, PubMed:9819425).
messages: Involved in pre-mRNA polyadenylation (PubMed:15121841, PubMed:9819425). May act to repress the ability of PAB1 to negatively regulate polyadenylation (PubMed:9819425). Negative regulator of poly(A) nuclease (PAN) activity (PubMed:15121841). Promotes mating-type switching in mother cells by positively regulating HO mRNA translation (PubMed:15082763). Localizes MKT1 to polysomes (PubMed:15082763).
messages: Mitochondrion
messages: Nucleus
messages: Present with 2870 molecules/cell in log phase SD medium.

559292:YLR115W
gene id: 559292:YLR115W
uniprot id: Q12102
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of at least PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Interacts with the CTD domain of RPB1/RNA polymerase II; the interaction is enhanced upon phosphorylation of the RPB1 CTD domain. Interacts with PCF11.
messages: Nucleus
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes.

559292:YLL010C
gene id: 559292:YLL010C
uniprot id: Q07800
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Has phosphatase activity in vitro. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR2. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.
messages: Interacts with WHI2.
messages: Present with 5620 molecules/cell in log phase SD medium.

559292:YDL055C
gene id: 559292:YDL055C
uniprot id: P41940
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.
messages: Present with 97100 molecules/cell in log phase SD medium.

559292:YDR405W
gene id: 559292:YDR405W
uniprot id: P32387
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uL23m forms the wall of the exit tunnel (PubMed:2060626, PubMed:9151978, PubMed:24675956). Interacts with the C-terminus of OXA1 (PubMed:14657017).
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: It is uncertain whether Met-1 or Met-11 is the initiator.
messages: Mitochondrion
messages: Present with 2200 molecules/cell in log phase SD medium.

559292:YIL077C
gene id: 559292:YIL077C
uniprot id: P40508
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUP1 family.
messages: Mitochondrion membrane
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YCR075C
gene id: 559292:YCR075C
uniprot id: P17261
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from vacuoles/endodomes.
messages: Endosome membrane
messages: Vacuole membrane

559292:YKL159C
gene id: 559292:YKL159C
uniprot id: P36054
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin.
messages: Present with 521 molecules/cell in log phase SD medium.

559292:YLR319C
gene id: 559292:YLR319C
uniprot id: P41697
names: Function
names: Miscellaneous
messages: Not essential for mitotic growth but is necessary for normal morphogenesis. Involved in the organization and/or function of the actin cytoskeleton.
messages: Present with 2610 molecules/cell in log phase SD medium.

559292:YDR131C
gene id: 559292:YDR131C
uniprot id: Q03899
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SKP1. Component of the probable SCF(YDR131C) complex containing CDC53, SKP1, RBX1 and YDR131C.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
messages: Vacuole

559292:YBR296C
gene id: 559292:YBR296C
uniprot id: P38361
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter. Active in early growth phase.
messages: The gene for PHO89 is only transcribed under conditions of phosphate limitation.

559292:YDR265W
gene id: 559292:YDR265W
uniprot id: Q05568
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:18644345, PubMed:19687296, PubMed:22471590, PubMed:35768507). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:18644345, PubMed:15283676, PubMed:35768507). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (PubMed:35768507).
messages: Peroxisome membrane
messages: The E3 ubiquitin-protein ligase activity is stimulated by PEX12.
messages: The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore (By similarity). The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex (By similarity).

559292:YDR240C
gene id: 559292:YDR240C
uniprot id: Q03782
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 18S U1 snRNP particle, a subcomplex of the spliceosome. Interacts with the nuclear cap-binding complex CBC1-CBC2 (yCBC). Directly contacts intronic sequences of substrate pre-RNA.
messages: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
messages: Nucleus
messages: Present with 361 molecules/cell in log phase SD medium.

559292:YGL216W
gene id: 559292:YGL216W
uniprot id: P53086
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
messages: Present with 736 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YNL155W
gene id: 559292:YNL155W
uniprot id: P53899
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: By transcriptional activator RPN4.
messages: Cytoplasm
messages: Interacts (via its ubiquitin-like domain) with CDC48 (via N-terminus). Associates with the 26S proteasome. Specifically interacts with the regulatory particle (RP) subunit RPN2. Exposure to arsenite, a known inducer of protein misfolding resulting in accumulation of polyubiquitinated conjugates, enhances the association with the proteoasome. Binds to ubiquitinated proteins conjugated to a 4 or more molecule ubiquitin chain. Binding to ubiquitinated proteins is zinc-dependent.
messages: Nucleus
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: Promotes efficient arsenite-induced clearance of stress granules (SGs) (PubMed:29804830). May have a role in the ubiquitin-proteasome system (UPS) protecting cells from metalloid-induced proteotoxicity (PubMed:24121501, PubMed:24297164).

559292:YJL221C
gene id: 559292:YJL221C
uniprot id: P0CW40
uniprot id: P0CW41
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides. Not required for isomaltose utilization, but overexpression allows the IMA1 null mutant to grow on isomaltose.
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm
messages: Present with 166 molecules/cell in log phase SD medium.

559292:YJR005W
gene id: 559292:YJR005W
uniprot id: P27351
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor.
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2). Interacts with APS2.
messages: Belongs to the adaptor complexes large subunit family.
messages: Cell membrane
messages: Present with 1670 molecules/cell in log phase SD medium.
messages: coated pit

559292:YKL034W
gene id: 559292:YKL034W
uniprot id: P36096
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalytic component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control (PubMed:25078903, PubMed:29355480). Mediates ubiquitination of vacuolar proteins such as CPS1, PPN1, PEP12 and other proteins containing exposed hydrophilic residues within their transmembrane domains, leading to their sorting into internal vesicles in late endosomes (PubMed:11788821). Targets also the unpalmitoylated endosomal SNARE TLG1 to the MVB pathway (PubMed:15973437).
messages: Component of the DSC E3 ligase complexes composed of at least TUL1, DSC2, DSC3, UBX3, CDC48 as well as VLD1 for the vacuole-localized complex or GLD1 for the Golgi/endosome-localized complex (PubMed:25078903, PubMed:29355480). Interacts with UBC4 (PubMed:11788821).
messages: Golgi apparatus membrane

559292:YNL217W
gene id: 559292:YNL217W
uniprot id: P40152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily.
messages: Vacuole

559292:YHR032W
gene id: 559292:YHR032W
uniprot id: P38767
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane
messages: Probable transporter involved in ethionine resistance. Overproduction leads to accumulation of S-adenosylmethionine.

559292:YCR042C
gene id: 559292:YCR042C
uniprot id: P23255
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF2 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.

559292:YGL230C
gene id: 559292:YGL230C
uniprot id: P53074
names: Subcellular Location Annotation
messages: Membrane

559292:YDL159W
gene id: 559292:YDL159W
uniprot id: P06784
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Phosphorylated at multiple sites in response to pheromone.
messages: Present with 672 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it is phosphorylated by the ste11 protein kinase and that it can phosphorylate the FUS3 and or KSS1 kinases.

559292:YHL040C
gene id: 559292:YHL040C
uniprot id: P38731
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Involved in the transport of siderophore ferrichrome and so has a role in iron homeostasis.

559292:YPL083C
gene id: 559292:YPL083C
uniprot id: Q02825
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEN54 family.
messages: Endomembrane system
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex.
messages: Nucleus
messages: Present with 531 molecules/cell in log phase SD medium.
messages: The tRNA splicing endonuclease complex is present with 100 molecules/cell.
messages: tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN2.

559292:YPR036W-A
gene id: 559292:YPR036W-A
uniprot id: Q3E752
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: By PDR1 through its PDRE-like promoter element.
messages: Defective sporulation accompanied by the appearance of pseudohyphal-like projections.
messages: Phosphorylated during meiosis. During meiosis, exists in both unphosphorylated and phosphorylated forms with the highest degree of phosphorylation occurring in mid-meiosis.
messages: Prospore membrane
messages: Required for efficient sporulation.

559292:YEL012W
gene id: 559292:YEL012W
uniprot id: P28263
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:1869573) (By similarity). Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:9737955, PubMed:10811607, PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:9737955, PubMed:10811607, PubMed:12686616, PubMed:28126757).
messages: Cytoplasm
messages: Present with 1590 molecules/cell in log phase SD medium.

559292:YIL049W
gene id: 559292:YIL049W
uniprot id: P40526
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.
messages: Suppression of filamentatous growth, defects in cell polarity, and cellular elongation, due to defects in N-glycosylation.

559292:YOR267C
gene id: 559292:YOR267C
uniprot id: Q08732
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Involved in regulating the activity of the plasma membrane proton pump PMA1.
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YGL021W
gene id: 559292:YGL021W
uniprot id: P43633
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
messages: Absent in G1-arrested cells and accumulates in G2-M.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
messages: Periodically phosphorylated during the cell cycle with a phosphorylation peak during mitosis and hyperphosphorylated after DNA damage.
messages: Present with 2190 molecules/cell in log phase SD medium.
messages: Serine/threonine haspin-like protein kinase involved in cell cycle regulation.
messages: The KEN and D (destructive) boxes are required for the cell cycle-controlled ALK1 degradation by the anaphase promoting complex (APC) pathway.
messages: The protein kinase domain is predicted to be catalytically inactive. However, weak kinase activity was experimentally demonstrated.

559292:YGL130W
gene id: 559292:YGL130W
uniprot id: Q01159
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic GTase family.
messages: Heterodimer (PubMed:6389537, PubMed:3029058). The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase (PubMed:6389537, PubMed:3029058).
messages: Nucleus
messages: Present with 279 molecules/cell in log phase SD medium.
messages: Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.

559292:YOR177C
gene id: 559292:YOR177C
uniprot id: Q08550
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts directly with SPO21/MPC70, NUD1, SPO74 and SPC42. Probable component of a spindle pole body (SPB) complex composed of ADY3, SSP1, DON1, MPC54, SPO21/MPC70, NUD1 and CNM67.
messages: Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation.
messages: Meiosis-specific. Expressed during meiosis II, from 3 to 9 hours after induction of sporulation. Not expressed during mitosis.
messages: Prospore membrane
messages: spindle pole
messages: spindle pole body

559292:YDR229W
gene id: 559292:YDR229W
uniprot id: Q04934
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homomultimer. Interacts with YPT7 and VPS33.
messages: May be required for vacuolar fusion. Overexpression leads to fragmentation of vacuoles, missorting of the vacuolar enzyme carboxypeptidase Y (CPY) to the exterior of the cell and accumulation of multivesicular bodies inside the cell.
messages: Present with 2840 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YPR048W
gene id: 559292:YPR048W
uniprot id: Q12181
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Mitochondrion
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:20802492). Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery (PubMed:20802492, PubMed:21902732). In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:20802492). Positively controls H(2)O(2)-induced cell death (PubMed:19194512).

559292:YBR227C
gene id: 559292:YBR227C
uniprot id: P38323
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 5-fold reduced production of the first heme precursor 5-aminolevulinic acid (ALA) and 2-fold reduction in total heme. In combination with a disruption of HEM25 or an inactivated HEM1, abrogates mitochondrial respiration.
messages: ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase (HEM1), thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Up-regulates heme biosynthesis.
messages: Belongs to the ClpX chaperone family.
messages: Homohexamer that forms a ring structure; this hexamerization requires ATP binding (By similarity). Interacts with HEM1 (PubMed:25957689).
messages: Mitochondrion inner membrane
messages: Present with 10900 molecules/cell in log phase SD medium.

559292:YHL023C
gene id: 559292:YHL023C
uniprot id: P38742
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NPR3 family.
messages: Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1. Forms a heterodimer with NPR2.
messages: Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.
messages: Vacuole membrane

559292:YHR205W
gene id: 559292:YHR205W
uniprot id: P11792
names: Activity Regulation
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Activated by cAMP.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Phosphorylated by TORC1 in nutrient-replete conditions and during mechanical stress.
messages: Present with 3850 molecules/cell in log phase SD medium.
messages: Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity (PubMed:20702584). Regulates ribosome biogenesis, translation initiation, and entry into stationary phase in a TORC1-dependent manner (PubMed:17560372).
messages: Sensitive to high hydrostatic pressure (mechanical stress); simultaneous disruption of RRD1 exacerbates the effect.

559292:YLR225C
gene id: 559292:YLR225C
uniprot id: Q05948
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Cytoplasm
messages: Present with 3990 molecules/cell in log phase SD medium.

559292:YNL224C
gene id: 559292:YNL224C
uniprot id: P53866
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SQS1 family.
messages: Cytoplasm
messages: May be involved in splicing since overexpression antagonizes the suppression of splicing defects by SPP382 mutants.
messages: Nucleus
messages: Present with 1440 molecules/cell in log phase SD medium.

559292:YML054C
gene id: 559292:YML054C
uniprot id: P00175
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: By L-lactate. Induced during respiratory adaptation.
messages: Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate with subsequent transfer of electrons to cytochrome c (PubMed:11914072). Is involved in the utilization of (S)-lactate as a sole source of carbon for growth (PubMed:3004948). Can also use ferricyanide as an electron acceptor in vitro (PubMed:4593578, PubMed:3004948).
messages: Consists of two discrete domains, an N-terminal cytochrome b domain from residues 81 to 179 and a C-terminal flavin-binding domain from residues 180 to 566. In addition there is an extended C-terminal tail (PubMed:2329585, PubMed:11914072). The cytochrome b domain is required for efficient cytochrome c reduction (PubMed:11914072).
messages: Homotetramer.
messages: In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
messages: In the N-terminal section; belongs to the cytochrome b5 family.
messages: Inactivation of this gene leads to a deficiency in L-lactate dehydrogenase activity and consequently to the inability to use L-lactate as a sole source of carbon.
messages: Mitochondrion intermembrane space
messages: Present with 4590 molecules/cell in log phase SD medium.

559292:YLR386W
gene id: 559292:YLR386W
uniprot id: Q06708
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VAC14 family.
messages: Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold.
messages: Present with 12388 molecules/cell in log phase SD medium.
messages: The N-terminal domain mediates interaction with FAB1 and VAC7 while the C-terminal domain mediates interaction with FIG4.
messages: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization. Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock. Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity.
messages: Vacuole membrane

559292:YMR196W
gene id: 559292:YMR196W
uniprot id: Q04336
names: Miscellaneous
messages: Present with 2220 molecules/cell in log phase SD medium.

559292:YJL162C
gene id: 559292:YJL162C
uniprot id: P46997
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 184 molecules/cell in log phase SD medium.

559292:YGL011C
gene id: 559292:YGL011C
uniprot id: P21243
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 15200 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with CIC1.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

559292:YHR185C
gene id: 559292:YHR185C
uniprot id: P38872
names: Function
names: Subcellular Location Annotation
messages: Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. Required to localize MPC54 to all four spindle pole bodies, and localize DON1 and SPO14 to four prospore membranes.
messages: Nucleus
messages: spindle pole body

559292:YML069W
gene id: 559292:YML069W
uniprot id: Q04636
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Transcription elongation is promoted by the repression of transcription initiation from cryptic sites. Also acts in establishing transcription initiation complexes and promotes SPT15/TBP-binding to a TATA box. Together with replication factor-A protein (RPA), FACT may play a role in nucleosome deposition during DNA replication.
messages: Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 (NHP6A or NHP6B) to form the FACT (yFACT or SNP) complex. The FACT complex interacts with the CK2 (casein kinase II) complex subunits CKA1, CKA2, CKB1 and CKB2 and the components of the transcription machinery CHD1, CTR9, PAF1 and CDC73. The FACT complex interacts with the PAF1 complex. SPT16 interacts with SAS3 and POL1. Interacts directly with RFA1.
messages: In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6A/NHP6B proteins in the FACT complex of yeast.
messages: Nucleus
messages: Present with 22400 molecules/cell in log phase SD medium.

559292:YJL035C
gene id: 559292:YJL035C
uniprot id: P47058
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Deaminates adenosine-34 to inosine in many tRNAs.
messages: Heterodimer with TAD3.
messages: Present with 830 molecules/cell in log phase SD medium.

559292:YLR097C
gene id: 559292:YLR097C
uniprot id: Q12347
names: Function
names: Subunit
messages: Interacts with SKP1. Component of the probable SCF(HRT3) complex containing CDC53, SKP1, RBX1 and HRT3.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).

559292:YKL139W
gene id: 559292:YKL139W
uniprot id: Q03957
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: CTDK-I consists of three subunits, CTK1, CTK2 and CTK3 (also called alpha, beta and gamma). Interacts directly with the CTK2 and CTK3 subunits, this interaction is required for kinase activity. Interacts with RNA polymerase I. Interacts with SNF1, but only at low glucose concentrations. Interacts with translating ribosomes.
messages: Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase II transcriptional elongation, and through PTI1, pre-mRNA 3'-end processing. Participates in both positive and negative regulation of CTD phosphorylation. Required for DNA damage induced transcription, including the expression of the RNR genes, and reprogramming of gene expression upon amino acid starvation. Required for SET2 mediated H3K36 methylation. Also regulates H3K4 methylation. Controls the maintenance of suppressive chromatin in the coding regions of genes by both promoting H3K36 methylation, which leads to histone deacetylation, and catalyzing phosphorylation of the CTD required to localize H3K4 chromatin modification specifically to the 5' ends of genes, thereby creating a boundary for H3K4 methylation that prevents a mark associated with transcriptional initiation from spreading into the bodies of genes. Involved in RNA polymerase I transcription. Involved in telomere maintenance. Acts together with SNF1 to induce GSY2 transcription in response to glucose limitation. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus. Functions in translation elongation by enhancing decoding fidelity. Needed for translational accuracy by phosphorylating RPS2.
messages: Cytoplasm
messages: Null mutants are viable, but grow more slowly than wild-type cells at 30 degrees Celsius. They are cold-sensitive, failing to grow at 12 degrees Celsius. They display flocculent growth in liquid media and they show abnormal cell morphologies, for example, a significant fraction of the cells are greatly enlarged. Deletion mutant has increased phosphorylation of 'Ser-5' of the CTD repeat during logarithmic growth. Deletion eliminates transient increase in CTD 'Ser-2' phosphorylation observed during diauxic shift. Deletion mutant is synthetically lethal when combined with deletion of DST1 or ELP genes. Deletion mutants are modestly sensitive to the uracil analog 6-azauracil (6AU), which inhibits elongation by depleting nucleotide pools. Deletion mutant is sensitive to the DNA synthesis inhibitor hydroxyurea (HU) and UV irradiation. 'Ser-2' phosphorylation within the CTD repeats is not increased in deletion mutants upon treatment with DNA-damaging agents.
messages: Phosphorylated on Thr-338 by CAK1. Phosphorylation is essential for the elevated CTD Ser-2 phosphorylation and required to activate transcription of stationary-phase genes during the diauxic shift.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YFL005W
gene id: 559292:YFL005W
uniprot id: P07560
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with the guanyl-nucleotide exchange factor SEC2. Interacts with SRO7, YIF1, YIP3, YIP4 and YIP5.
messages: Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle.
messages: secretory vesicle membrane

559292:YJR061W
gene id: 559292:YJR061W
uniprot id: P40355
names: Similarity
messages: To yeast MNN4.

559292:YJL068C
gene id: 559292:YJL068C
uniprot id: P40363
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Monomer.
messages: Present with 1750 molecules/cell in log phase SD medium.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

559292:YFR015C
gene id: 559292:YFR015C
uniprot id: P23337
names: Activity Regulation
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Activity increases just before cells entry in the stationary phase.
messages: Allosteric activation by glucose-6-phosphate, and phosphorylation by a cAMP-dependent kinase.
messages: Belongs to the glycosyltransferase 3 family.
messages: Present with 6300 molecules/cell in log phase SD medium.
messages: Synthesized in response to growth limitation.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen.

559292:YMR207C
gene id: 559292:YMR207C
uniprot id: P32874
names: Caution
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions: biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase.
messages: Mitochondrion
messages: Present with 396 molecules/cell in log phase SD medium.
messages: The reading frame from which this protein is translated has no Met initiation codon near to the 5'-end. However, it is not a pseudogene. It has been shown (PubMed:14761959) that at least 72 residues upstream of the first in-frame start codon (Met-151) are required for function and proper subcellular location. May be translated by means of alternative initiation codon usage, programmed translational frame shifting, or mRNA editing.

559292:YIL138C
gene id: 559292:YIL138C
uniprot id: P40414
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Involved in cell morphogenesis. Binds to F-actin and stabilizes the actin filaments.
messages: Present with 11100 molecules/cell in log phase SD medium.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

559292:YLR378C
gene id: 559292:YLR378C
uniprot id: P32915
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Component of the heterotrimeric Sec61 complex, which is composed of SEC61, SBH1 and SSS1. Presumably three to four Sec61 heterotrimers assemble into an oligomeric ring with a central aqueous pore. In cotranslational ER import, the pore diameter varies from 9-15 A in a ribosome-free resting state to 40-60 A in a functional state when associated with the ribosome. The Sec61 complex is part of a channel-forming translocon complex whose composition seem to change dependent upon different functional states. During post-translational ER import the Sec61 complex associates with the Sec62/63 complex to form the Sec complex. SEC61 interacts with STT3, OST1, OST2, OST4, SWP1 and WBP1 components of the OT complex.
messages: Endoplasmic reticulum membrane
messages: Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. In an initial step, the signal sequence seems to bind simultaneously to SEC61 and SEC62. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC61 mediates the association with the ribosome.
messages: Present with 24800 molecules/cell in log phase SD medium.

559292:YNL238W
gene id: 559292:YNL238W
uniprot id: P13134
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Binds 3 Ca(2+) ions per subunit.
messages: O-glycosylated.
messages: Processing of precursors of alpha-factors and killer toxin.
messages: trans-Golgi network membrane

559292:YGR289C
gene id: 559292:YGR289C
uniprot id: P53048
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: By maltose and maltotriose (PubMed:10618490, PubMed:12210897, PubMed:8594329). Repressed by glucose (PubMed:10618490, PubMed:12210897, PubMed:8594329).
messages: Cell membrane
messages: High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system).

559292:YOR048C
gene id: 559292:YOR048C
uniprot id: Q02792
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Inhibited by nucleoside 3', 5'-bisphosphates.
messages: Interacts with RAI1 and RTT103.
messages: Nucleus
messages: Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA, rRNA and small nucleolar RNA (snoRNA) precursors. May promote termination of transcription by RNA polymerase II via the recruitment of 3'-end processing factors to the poly(A) site and by the degradation of nascent RNA downstream of the poly(A) site.
messages: Present with 623 molecules/cell in log phase SD medium.

559292:YPL042C
gene id: 559292:YPL042C
uniprot id: P39073
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Component of the SRB8-11 complex which consists of SRB8, SSN2/SRB9, SSN3/SRB10 and SSN8/SRB11. The SRB8-11 complex associates with the Mediator complex. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair also associate with the RNA polymerase II holoenzyme. Interacts with TUP1.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions. Phosphorylates GCN4, promoting its ubiquitin-mediated degradation, and MSN2, promoting its nuclear exclusion. Phosphorylates STE12, thereby promoting its degradation and inhibition of filamentous growth. Phosphorylates GAL4, and this phosphorylation is required for efficient galactose-inducible transcription. Also phosphorylates BDF1 and the TAF2 subunit of the TFIID complex.
messages: Nucleus
messages: Protein level and kinase activity are reduced during nitrogen starvation.

559292:YHR138C
gene id: 559292:YHR138C
uniprot id: P38841
names: Miscellaneous
names: Similarity
messages: Belongs to the protease inhibitor I9 family.
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YNL306W
gene id: 559292:YNL306W
uniprot id: P42847
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 5300 molecules/cell in log phase SD medium.

559292:YLR277C
gene id: 559292:YLR277C
uniprot id: Q06224
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of at least PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Interacts with FIP1, PFS2, RNA14 and YTH1.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Has endonuclease activity.
messages: Nucleus
messages: Present with 17400 molecules/cell in log phase SD medium.

559292:YMR185W
gene id: 559292:YMR185W
uniprot id: Q12751
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tango6 family.
messages: Cytoplasm
messages: Interacts with RNA polymerase II subunits RPB2 and RPB3. Interacts with the R2TP complex. Interacts with the nuclear pore complex subunits NUP100 and NUP116.
messages: Required for the cytoplasmic assembly and the nuclear import of RNA polymerase II. May facilitate the starting interaction between RNA polymerase II subunits RPB2 and RPB3 and the subsequent interaction of the resulting complex with subunit RPB1. May also participate in the transport of RNA polymerase II through the nuclear pore complex.

559292:YKL096C-B
gene id: 559292:YKL096C-B
uniprot id: Q8TGT2
names: Subcellular Location Annotation
messages: Membrane

559292:YDR018C
gene id: 559292:YDR018C
uniprot id: Q12185
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

559292:YBR216C
gene id: 559292:YBR216C
uniprot id: P38315
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YBP1 family.
messages: Cytoplasm
messages: Interacts with YAP1. Forms a peroxide stress induced complex with YAP1 in the cytoplasm. Systematic proteome-wide 2-hybrid interaction studies suggest that YAP1, HYR1/GPX3, and YBP1 all interact with the nuclear pore complex subunit NUP116, which is involved in nucleocytoplasmic transport.
messages: Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of YAP1. Functions probably in concert with HYP1/GPX3, the actual YAP1 modifying enzyme. YBP1 is not required for HYP1/GPX3-independent, diamide-induced oxidation of YAP1.
messages: Present with 3100 molecules/cell in log phase SD medium.
messages: YBP1 encoded by the widely used laboratory strain W303-1a is only partially functional, probably due to four amino acid substitutions.

559292:YBL060W
gene id: 559292:YBL060W
uniprot id: P34225
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YEL1 family.
messages: Bud neck
messages: Bud tip
messages: Cell membrane
messages: Cytoplasm
messages: Guanine-nucleotide exchange factor for ARF3 required for localization of ARF3 to the bud neck and tip and involved in actin patch polarization.

559292:YKL181W
gene id: 559292:YKL181W
uniprot id: P32895
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Cytoplasm
messages: Present with 11700 molecules/cell in log phase SD medium.

559292:YGR172C
gene id: 559292:YGR172C
uniprot id: P53039
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YIP1 family.
messages: Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1. The complex interacts with the ER to Golgi SNAREs BOS1 and SEC22. Interacts with the prenylated form of the Rab GTPases YPT1 and YPT31. Interacts with the YIP1 family members YIP4 and YIP5. Interacts with SNX3, YIP3 and YOP1.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport, probably by mediating correct membrane localization of YPT1.

559292:YPR140W
gene id: 559292:YPR140W
uniprot id: Q06510
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (PubMed:14651618, PubMed:28202545, PubMed:29091407). Its role in cellular physiology is to improve mitochondrial performance (By similarity). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (PubMed:16135531). Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor (By similarity). CoA-independent, it can reshuffle molecular species within a single phospholipid class (PubMed:15588229). Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such a…
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: Present with 1340 molecules/cell in log phase SD medium (PubMed:14562106). The enzyme was named after a masochistic character Tafazzi, once popular on Italian television, apparently due to the difficulty encountered for its identification and characterization (By similarity).
messages: The HXXXXD motif is essential for acyltransferase activity.

559292:YLL061W
gene id: 559292:YLL061W
uniprot id: Q12372
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Endoplasmic reticulum
messages: High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source.
messages: Membrane

559292:YAL053W
gene id: 559292:YAL053W
uniprot id: P39719
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Endoplasmic reticulum membrane
messages: May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YJR034W
gene id: 559292:YJR034W
uniprot id: Q02772
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET191 family.
messages: Involved in the assembly of cytochrome c oxidase.
messages: Mitochondrion intermembrane space
messages: The twin Cx9C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.

559292:YGR052W
gene id: 559292:YGR052W
uniprot id: P53233
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: By treatment with 8-methoxypsoralen and UVA irradiation.
messages: Mitochondrion
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YOR026W
gene id: 559292:YOR026W
uniprot id: P26449
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BUB3 family.
messages: Component of the mitotic checkpoint complex (MCC) which consists of MAD2, MAD3, BUB3 and CDC20. Part of complex consisting of MAD1, BUB1 and BUB3 after activation of spindle checkpoint. Interacts with MAD1, MAD2 and CDC20.
messages: Nucleus
messages: Phosphorylated by BUB1.
messages: Present with 1430 molecules/cell in log phase SD medium.
messages: Required for cell cycle arrest in response to loss of microtubule function. Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.

559292:YHR147C
gene id: 559292:YHR147C
uniprot id: P32904
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 5700 molecules/cell in log phase SD medium.

559292:YLR088W
gene id: 559292:YLR088W
uniprot id: P39012
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the GPI transamidase complex. Required for a terminal step of GPI anchor attachment onto proteins. Affects endocytosis.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with CDC91, GPI17, GPI16 and GPI8.

559292:YDR202C
gene id: 559292:YDR202C
uniprot id: Q03956
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RAVE complex composed of RAV1, RAV2 and CBF3D/SKP1. Within the complex, it interacts directly with RAV1 and CBF3D. Interacts with the V-ATPase V1 subunits VMA1, VMA2 and VMA8.
messages: Component of the RAVE complex, which is required for stable assembly of the vacuolar ATPase complex V-ATPase under many conditions. May be required for transport between the early endosome and the late endosome/prevacuolar compartment (PVC).
messages: Cytoplasm
messages: Early endosome membrane
messages: Present with 2860 molecules/cell in log phase SD medium.

559292:YMR052W
gene id: 559292:YMR052W
uniprot id: P46671
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
messages: Endoplasmic reticulum
messages: Participates in the control of the reentry into the cell cycle following pheromone treatment.
messages: Present with 1540 molecules/cell in log phase SD medium.

559292:YOL077C
gene id: 559292:YOL077C
uniprot id: Q08235
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRX1 family.
messages: Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.
messages: Present with 13200 molecules/cell in log phase SD medium.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

559292:YDL150W
gene id: 559292:YDL150W
uniprot id: P25441
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC37/RPC5. RPC53/RPC4, RPC37/RPC5 and RPC11/RPC10 probably form a Pol III subcomplex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.
messages: Nucleus
messages: Present with 998 molecules/cell in log phase SD medium.

559292:YNL071W
gene id: 559292:YNL071W
uniprot id: P12695
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.
messages: Mitochondrion matrix
messages: Present with 5440 molecules/cell in log phase SD medium.
messages: The E2 component contains covalently-bound lipoyl cofactors and it participates in the generation of acetyl groups from hydroxyethyl-thiamine pyrophosphate-E1 and their transfer to coenzyme A.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

559292:YIL126W
gene id: 559292:YIL126W
uniprot id: P32597
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is the essential ATPase of the complex. It is a DNA translocase capable of nucleosome remodeling. Required for full expression of early meiotic genes. Essential for mitotic growth and repression of CHA1 expression. Also involved in G2 phase control.
messages: Interacts directly with SFH1, CSE4, histones H3, H4 and H2B, and via its N-terminus, with RSC8. Interacts with LDB7, NPL6 and RTT102. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
messages: Nucleus
messages: Present with 1990 molecules/cell in log phase SD medium.

559292:YLR080W
gene id: 559292:YLR080W
uniprot id: Q12396
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP46/EMP47 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with EMP47 in the endoplasmic reticulum membrane in order to be transported to the Golgi apparatus. Interacts with the coatomer proteins COP1, SEC21 and SEC23.
messages: Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

559292:YBR138C
gene id: 559292:YBR138C
uniprot id: P38277
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YKL047W
gene id: 559292:YKL047W
uniprot id: P36090
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Lipid droplet
messages: May be involved in lipid metabolism.
messages: Palmitoylated by AKR1.
messages: Present with 2550 molecules/cell in log phase SD medium.

559292:YML123C
gene id: 559292:YML123C
uniprot id: P25297
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: High-affinity transporter for external inorganic phosphate. Is not an essential protein, since a constitutive, low affinity pI transporter exists in yeast.
messages: May function as a monomer.
messages: Membrane
messages: Present with 335000 molecules/cell in log phase SD medium.
messages: Under the control of phosphate. It is derepressed by phosphate starvation.

559292:YDL209C
gene id: 559292:YDL209C
uniprot id: Q12046
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome subcomplex composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with ISY1. Interacts with PRP19.
messages: Belongs to the RRM CWC2 family.
messages: Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Binds also to U1, U4, U5 and U6 snRNAs and to pre-mRNAs, in vitro. Is not required for the Prp2-mediated remodeling of the activated spliceosome.
messages: Nucleus
messages: Present with 2650 molecules/cell in log phase SD medium.
messages: The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.

559292:YPL004C
gene id: 559292:YPL004C
uniprot id: Q12230
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: N-glycosylated.
messages: Phosphorylated by PKH1 and PKH2. Phosphorylation is stimulated by sphingolipid long chain bases (LCBs).
messages: Present with 104485 molecules/cell in log phase SD medium.
messages: Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.
messages: cell cortex

559292:YPL186C
gene id: 559292:YPL186C
uniprot id: Q08926
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with ULP1.
messages: Mitochondrion outer membrane
messages: Nucleus envelope

559292:YIL099W
gene id: 559292:YIL099W
uniprot id: P08019
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

559292:YDR127W
gene id: 559292:YDR127W
uniprot id: P08566
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: In the 2nd section; belongs to the EPSP synthase family.
messages: In the 3rd section; belongs to the shikimate kinase family.
messages: In the 4th section; belongs to the type-I 3-dehydroquinase family.
messages: In the C-terminal section; belongs to the shikimate dehydrogenase family.
messages: In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Present with 6420 molecules/cell in log phase SD medium.
messages: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

559292:YGL220W
gene id: 559292:YGL220W
uniprot id: P53082
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BolA/IbaG family.
messages: Cytoplasm
messages: Interacts with FRA1, GRX3 and GRX4.
messages: Involved in the regulation of the iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. May be involved in mitochondrial organization and biogenesis.
messages: Nucleus
messages: Present with 2050 molecules/cell in log phase SD medium.

559292:YOR049C
gene id: 559292:YOR049C
uniprot id: Q08417
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.
messages: Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.
messages: Cell membrane
messages: In response to loss of mitochondrial DNA in a transcription factor PDR3-dependent manner. Induced in response to altered glycerophospholipid asymmetry of the plasma membrane in a transcription factor PDR1-dependent manner.

559292:YEL021W
gene id: 559292:YEL021W
uniprot id: P03962
names: Similarity
messages: Belongs to the OMP decarboxylase family.

559292:YDR514C
gene id: 559292:YDR514C
uniprot id: Q04408
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Nucleus
messages: Present with 125 molecules/cell in log phase SD medium.

559292:YGL055W
gene id: 559292:YGL055W
uniprot id: P21147
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:1978720, PubMed:7947684). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:1978720, PubMed:2674136). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:1978720, PubMed:7947684, PubMed:16443825). Regulates fatty acid desaturation, that is, the ratio of unsaturated versus saturated fatty acyl chains, by competing with the acyltransferase STC1 for the common substrate C16:0-CoA. SCT1 sequesters C16:0-CoA into lipids, thereby shielding it from desaturation by OLE1 (PubMed:22323296).
messages: The histidine box domains are involved in binding the catalytic metal ions.

559292:YBR029C
gene id: 559292:YBR029C
uniprot id: P38221
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDS family.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade.
messages: secretory vesicle

559292:YHR051W
gene id: 559292:YHR051W
uniprot id: P00427
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). COX26 interacts with COX1, COX2, COX6 and COX9 (PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX6 may stabilize the region of CIV at the interface with CIII, supporting a role in formation or stability of the CIII(2)IV(2) SC (PubMed:30598554).
messages: Mitochondrion inner membrane
messages: Present with 12500 molecules/cell in log phase SD medium.

559292:YDR258C
gene id: 559292:YDR258C
uniprot id: P33416
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: By heat stress. Expressed at a higher level in respiring cells than in fermenting cells (at protein level).
messages: Has 2 AAA ATPase type nucleotide-binding domains (NBDs) per monomer. NBD1 is primarily responsible for ATP hydrolysis. NBD2 is crucial for oligomerization.
messages: Homohexamer, forming a ring with a central pore. The hexamer is stabilized by high protein concentrations and by ADP or ATP. Oligomerization influences ATP hydrolysis activity.
messages: Mitochondrion matrix
messages: Present with 2990 molecules/cell in log phase SD medium.
messages: Required, in concert with mitochondrial Hsp70 (SSC1), for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress. Its main role may be maintaining the molecular chaperone SSC1 in a soluble and functional state. Also required for the efficient degradation of proteins by matrix protease PIM1, independent on its protein remodeling activity.

559292:YDR520C
gene id: 559292:YDR520C
uniprot id: Q04411
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the URC2 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 937 molecules/cell in log phase SD medium.
messages: Probable transcriptional activator involved in uracil catabolism.

559292:YDL104C
gene id: 559292:YDL104C
uniprot id: P43122
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homodimer.
messages: Loss of QRI7 leads to the formation of mitochondria with abnormal morphology and no DNA.
messages: Mitochondrion
messages: Present with 1400 molecules/cell in log phase SD medium.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

559292:YDL061C
gene id: 559292:YDL061C
uniprot id: P41058
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 5410 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS14 in yeast.

559292:YGR109C
gene id: 559292:YGR109C
uniprot id: P32943
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Involved in G1/S and or S phase progression. Interacts with CDC28.
messages: Maximally expressed just before cell cycle start.

559292:YMR153W
gene id: 559292:YMR153W
uniprot id: Q03790
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP53 interacts with MAD1-MAD2. During mitosis NUP53 changes its binding partner within the NPC from NUP170 to NIC96, exposing a high affinity binding site for the karyopherin PSE1, and retaining it in the NPC, while MAD2 is released. It forms a subcomplex with ASM4 and NDC1.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.
messages: Nucleus membrane
messages: Phosphorylated by CDC28.
messages: Present with 2060 molecules/cell in log phase SD medium.
messages: The RRM Nup35-type domain might be involved in the control of mitosis.
messages: nuclear pore complex

559292:YIL062C
gene id: 559292:YIL062C
uniprot id: P40518
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: actin patch

559292:YLR156W
gene id: 559292:YLR156W
uniprot id: P0CE96
uniprot id: P0CE97
uniprot id: P0CE98
names: Miscellaneous
messages: There are 3 tandem-duplicated genes coding for this protein in S.cerevisiae (YLR156W, YLR159W and YLR161W). Additionally, a fourth copy has been disrupted by a Ty1 retrotransposon, which led to the prediction of the 2 dubious ORFs YLR157W-D and YLR157W-E.

559292:YDL053C
gene id: 559292:YDL053C
uniprot id: Q07362
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with IGO1, LSM12 and PBP1.
messages: Nucleus
messages: Present with 1560 molecules/cell in log phase SD medium.

559292:YBR059C
gene id: 559292:YBR059C
uniprot id: P38080
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Phosphorylates SCD5.
messages: Present with 3000 molecules/cell in log phase SD medium.

559292:YHR007C-A
gene id: 559292:YHR007C-A
uniprot id: Q07074
names: Subcellular Location Annotation
messages: Membrane

559292:YLR195C
gene id: 559292:YLR195C
uniprot id: P14743
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Uncharged amino acids are preferred at position 2 while neutral residues are favored at positions 3 and 4. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6.
messages: Belongs to the NMT family.
messages: Cytoplasm
messages: Has an ordered Bi-Bi kinetic mechanism, with myristoyl-CoA binding taking place prior to peptide binding and CoA release occurring before acylated peptide release. Cooperative interactions between the acyl-CoA and peptide binding sites of NMT contribute to its extraordinary chain-length specificity.
messages: Inhibited by diethylpyrocarbonate. Competitively inhibited by S-(2-oxo)pentadecyl-CoA, a non hydrolysable myristoyl-CoA analog, and by SC-58272, a peptidomimetic derived from the N-terminal sequence of a natural substrate.
messages: Monomer.
messages: The N-terminus is blocked.

559292:YOR098C
gene id: 559292:YOR098C
uniprot id: P20676
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. Interacts through its FG repeats with nuclear transport receptors. Binds to the nuclear basket of the NPC through NUP60. Interacts with KAP122.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: FXFG repeats are especially abundant in NUPs on the nucleoplasmic side (in a highly charged environment and enriched in Ser and Thr).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP1 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP2 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP1 binds through its C-terminus to KAP95, thus accelerating the release of KAP95 and, indirectly, of the nuclear localization signal (NLS)-containing cargo from the SRP1-KAP95-cargo complex.
messages: Nucleus membrane
messages: Phosphorylated by CDC28.
messages: Present with 468 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YMR261C
gene id: 559292:YMR261C
uniprot id: P38426
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.
messages: Present with 13500 molecules/cell in log phase SD medium.
messages: Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex.
messages: Repressed by glucose.
messages: The trehalose synthase complex is composed of the two catalytic subunits TPS1 and TPS2 and at least one of the two regulatory subunits TPS3 or TSL1.

559292:YPL230W
gene id: 559292:YPL230W
uniprot id: Q12132
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Nucleus
messages: Repressed by glucose but is activated in the presence of non-fermentable carbon sources or salt stress. The latter transcriptional activation of NSF1 is partially dependent on the SNF1 signaling pathway.
messages: Transcription factor that participates in the transcriptional activation of glucose-repressed genes during exponential growth in non-fermentable carbon conditions. Also involved in salt-stress response.

559292:YIR006C
gene id: 559292:YIR006C
uniprot id: P32521
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAN1 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. Required for the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface.
messages: Endosome membrane
messages: Forms homooligomers. Component of the PAN1 actin cytoskeleton-regulatory complex composed of at least END3, PAN1, and SLA1. Interacts directly with END3, and with ENT1, SCD5, SLA2, YAP1801 and YAP1802.
messages: Phosphorylated by PRK1 on threonine residues in the L-x-x-Q-x-T-G motif of repeats 1-6 to 1-15 (PubMed:9885245, PubMed:11739778, PubMed:17978096). Phosphorylated by ARK1 (PubMed:17978096).
messages: The N-terminus is blocked.
messages: Was originally thought to be a subunit of PAB-dependent poly(A)-specific ribonuclease.
messages: actin patch

559292:YOL098C
gene id: 559292:YOL098C
uniprot id: Q12496
names: Miscellaneous
messages: Present with 8120 molecules/cell in log phase SD medium.

559292:YPL030W
gene id: 559292:YPL030W
uniprot id: Q02648
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM44 family.
messages: Cytoplasm
messages: Present with 7720 molecules/cell in log phase SD medium.
messages: tRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (Um44) in tRNA(Ser).

559292:YIL125W
gene id: 559292:YIL125W
uniprot id: P20967
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: Catabolite repressed.
messages: Mitochondrion matrix
messages: Present with 14300 molecules/cell in log phase SD medium.
messages: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
messages: mitochondrion nucleoid

559292:YJR011C
gene id: 559292:YJR011C
uniprot id: P47086
names: Miscellaneous
messages: Present with 2560 molecules/cell in log phase SD medium.

559292:YJR154W
gene id: 559292:YJR154W
uniprot id: P47181
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PhyH family.
messages: Cytoplasm
messages: Present with 1600 molecules/cell in log phase SD medium.

559292:YOR343W-A
gene id: 559292:YOR343W-A
uniprot id: Q12293
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YLR015W
gene id: 559292:YLR015W
uniprot id: P43132
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the COMPASS (Set1C) complex which consists of SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and SWD3(1).
messages: Nucleus
messages: Present with 1310 molecules/cell in log phase SD medium.
messages: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: telomere

559292:YEL001C
gene id: 559292:YEL001C
uniprot id: P40006
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRC22 family.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.
messages: Endoplasmic reticulum membrane
messages: Is probably involved in a pathway contributing to genomic integrity.
messages: Present with 7110 molecules/cell in log phase SD medium.

559292:YNL257C
gene id: 559292:YNL257C
uniprot id: P38717
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIP3 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SNF1.
messages: May be involved in sterol transfer between intracellular membranes.
messages: Present with 432 molecules/cell in log phase SD medium.
messages: The VASt domain bind sterols.

559292:YMR302C
gene id: 559292:YMR302C
uniprot id: P32843
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YME2 family.
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.
messages: Present with 5260 molecules/cell in log phase SD medium.

559292:YJL069C
gene id: 559292:YJL069C
uniprot id: P40362
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat UTP18 family.
messages: Interacts with snoRNA U3. Interacts with MPP10, UTP21 and UTP25. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: Present with 9570 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDL033C
gene id: 559292:YDL033C
uniprot id: Q12093
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
messages: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
messages: Mitochondrion
messages: Present with 1510 molecules/cell in log phase SD medium.
messages: Was originally thought to be a 5-methylaminomethyl-2-methyltransferase involved in tRNA modification.

559292:Q0275
gene id: 559292:Q0275
uniprot id: P00420
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX3 is a catalytic core subunit (PubMed:30598554).
messages: Mitochondrion inner membrane
messages: The N-terminus is blocked.

559292:YIR037W
gene id: 559292:YIR037W
uniprot id: P40581
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: In contrast to the other two peroxiredoxins, HYR1/GPX3 expression is constitutive, not stress-induced.
messages: Interacts with YAP1 and probably YBP1.
messages: Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYR1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYR1/GPX3 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598'), which causes its nuclear accumulation and activation, and a reduced Cys-36 in HYR1/GPX3.
messages: Mitochondrion intermembrane space
messages: Peroxisome matrix
messages: Present with 8000 molecules/cell in log phase SD medium.
messages: Sensitive to hydrogen peroxide and tert-butyl hydroperoxide (t-BHP).
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide.
messages: Was originally thought to be a glutathione peroxidase (PubMed:10480913) or a phospholipid hydroperoxide glutathione peroxidase (PubMed:11445588), but functions as an atypical 2-Cys peroxiredoxin using thioredoxin as reducing power instead (PubMed:12437921).

559292:YGL041C-B
gene id: 559292:YGL041C-B
uniprot id: Q3E750
names: Subcellular Location Annotation
messages: Membrane

559292:YPR086W
gene id: 559292:YPR086W
uniprot id: P29055
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.
messages: Belongs to the TFIIB family.
messages: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
messages: Nucleus
messages: Present with 6750 molecules/cell in log phase SD medium.

559292:YDR211W
gene id: 559292:YDR211W
uniprot id: P32501
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as a catalytic component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD6 and GCD7 repress GCN4 expression at the translational level by ensuring that ribosomes which have translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail to reach the GCN4 start site.
messages: Belongs to the eIF-2B gamma/epsilon subunits family.
messages: Present with 33800 molecules/cell in log phase SD medium.
messages: Translation initiation factor 2B (eIF2-B) is composed of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6). A catalytic subcomplex comprising GCD1 and GCD6 interacts with both, phosphorylated and non-phosphorylated eIF-2 and has exchange activity in vitro. GCD6 interacts with SUI3.

559292:YMR199W
gene id: 559292:YMR199W
uniprot id: P20437
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the cyclin family.
messages: CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.
messages: Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YGR077C
gene id: 559292:YGR077C
uniprot id: P53248
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Peroxisome matrix
messages: Present with 538 molecules/cell in log phase SD medium.
messages: Required for peroxisome assembly.

559292:YHR023W
gene id: 559292:YHR023W
uniprot id: P08964
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Present with 2140 molecules/cell in log phase SD medium.
messages: Required for cell division.

559292:YER188C-A
gene id: 559292:YER188C-A
uniprot id: P0C0V2
names: Similarity
messages: Belongs to the UPF0320 family.

559292:YBR187W
gene id: 559292:YBR187W
uniprot id: P38301
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Expression is GCR1-dependent. Promoter is also bound by the RAP1 transcription factor.
messages: Golgi apparatus membrane
messages: May be involved in ribosome biogenesis. Has also been proposed to play a role in calcium homeostasis (PubMed:23569283).
messages: Present with 2170 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YGR001C
gene id: 559292:YGR001C
uniprot id: P53200
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-79' (PubMed:25446118). Required for replication of Brome mosaic virus (BMV) (PubMed:14671320).
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

559292:YJL139C
gene id: 559292:YJL139C
uniprot id: P26725
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Golgi apparatus membrane
messages: Possible glycosyltransferase involved in N-linked glycosylation. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
messages: Present with 6400 molecules/cell in log phase SD medium.

559292:YNL247W
gene id: 559292:YNL247W
uniprot id: P53852
names: Cofactor
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.
messages: Present with 23000 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YDL218W
gene id: 559292:YDL218W
uniprot id: Q07629
names: Induction
names: Subcellular Location Annotation
messages: Induced under aerobic conditions.
messages: Membrane

559292:YPL040C
gene id: 559292:YPL040C
uniprot id: P48526
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YNL058C
gene id: 559292:YNL058C
uniprot id: P53947
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM5 family.
messages: Vacuole membrane

559292:YDR473C
gene id: 559292:YDR473C
uniprot id: Q03338
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Nucleus
messages: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
messages: Present with 432 molecules/cell in log phase SD medium.

559292:YJL145W
gene id: 559292:YJL145W
uniprot id: P47008
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFH5 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses (PubMed:32780017).
messages: Present with 6540 molecules/cell in log phase SD medium.

559292:YDL132W
gene id: 559292:YDL132W
uniprot id: Q12018
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cullin family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1/HRT1, RBX1 and a variable F-box domain-containing protein as substrate-specific adapter. Component of the SCF(CDC4) complex containing CDC4. Component of the SCF(MET30) complex containing MET30. Component of the SCF(GRR1) complex containig GRR1. Component of the probable SCF(DIA2) complex containing DIA2. Component of the probable SCF(YDR131C) complex containing YDR131C. Component of the probable SCF(YDR306C) complex containing YDR306C. Component of the probable SCF(YLR224W) complex containing YLR224W. Component of the probable SCF(YJL149W) complex containing YJL149W. Component of the probable SCF(YNL311C) complex containing YNL311C. Component of the probable SCF(MDM30) complex containing MDM30. Component of the probable SCF(UFO1) complex containing UFO1. Component of the probable SCF(HRT3) complex containing HRT3. Component of the probable SCF(YBR280C) complex containing YBR280C. Component of the probable SCF(YBR352W) complex containing YBR352W. Interacts with DCN1, YBR280C, YLR224W and YLR352W. The unneddylated form interacts with LAG2/CAND1 and the interaction mediates the exchange of the F-box substrate-specific subunit.
messages: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The SCF complex associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the SCF complex depends on the type of F-box protein. SCF(CDC4) controls the G1-to-S phase transition; it directs ubiquitination of the phosphorylated CDK inhibitor SIC1 and of CDC6. SCF(CDC4) directs ubiquitination of GCN4. SCF(GRR1) directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. SCF(MET30) directs ubiquitination of MET4. SCF(DIA2) is specifically involved in the pheromone induced degradation of phosphorylated TEC1. SCF(MDM30) seems to direct ubiquitination of FZ01. Involved in the regulation of methionine biosynthesis genes.
messages: Cytoplasm
messages: Neddylated; enhancing the ubiquitin-ligase activity.
messages: Nucleus
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YDR348C
gene id: 559292:YDR348C
uniprot id: Q05518
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pal1 family.
messages: Cell membrane
messages: Interacts with EDE1.
messages: Involved in the early step of endocytosis.
messages: Present with 1480 molecules/cell in log phase SD medium.

559292:YLR383W
gene id: 559292:YLR383W
uniprot id: Q12749
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Probably plays a role in structure.
messages: Belongs to the SMC family. SMC6 subfamily.
messages: Chromosome
messages: Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6.
messages: Nucleus
messages: Present with 339 molecules/cell in log phase SD medium.
messages: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.

559292:YOL015W
gene id: 559292:YOL015W
uniprot id: Q08118
names: Induction
messages: During anaerobic conditions.

559292:YKL224C
gene id: 559292:YKL224C
uniprot id: P35994
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YDL229W
gene id: 559292:YDL229W
uniprot id: P11484
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.
messages: Binds to ribosomes (PubMed:9670014, PubMed:1394434, PubMed:27917864). Binds close to the ribosomal tunnel exit via contacts with both ribosomal proteins RPL35, RPL39 and RPL19, and rRNA (PubMed:27882919). Directly interacts with nascent polypeptides. This interaction is dependent on the ribosome-associated complex (RAC) (PubMed:11929994, PubMed:23332755). Interacts with SSE1 (PubMed:16219770, PubMed:16221677, PubMed:23332755). Interacts with FES1 (PubMed:17132105). Interacts with NAP1 (PubMed:18086883).
messages: Cytoplasm
messages: Expression decreases after heat shock or during growth to stationary phase (PubMed:6761581, PubMed:2651414). Degraded during heat shock treatment (at protein level) (PubMed:7646503). Up-regulated upon carbon upshift and down-regulated upon amino acid limitation in an HSF1-dependent manner (PubMed:10322015).
messages: Present with 170000 molecules/cell in log phase SD medium.
messages: Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone SSE1 and FES1 act as nucleotide exchange factors that cause substrate release.

559292:YLR075W
gene id: 559292:YLR075W
uniprot id: P41805
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

559292:YJR078W
gene id: 559292:YJR078W
uniprot id: P47125
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Catalyzes the first step in tryptophan catabolism in order to supply de novo nicotinamide adenine dinucleotide (NAD(+)) via the kynurenine pathway. Plays a role in the cellular response to telomere uncapping.
messages: Expression is mediated by the AFT2, HCM1, and SUM1 transcription factors. Up-regulated in absence of NPT1.
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YMR222C
gene id: 559292:YMR222C
uniprot id: Q05015
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase 3 family.
messages: Cytoplasm
messages: Present with 1070 molecules/cell in log phase SD medium.
messages: Serine hydrolase of unknown specificity.

559292:YBR293W
gene id: 559292:YBR293W
uniprot id: P38358
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine.
messages: Vacuole membrane

559292:YJL094C
gene id: 559292:YJL094C
uniprot id: P40309
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
messages: Membrane
messages: Potassium-proton antiport.
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YAL011W
gene id: 559292:YAL011W
uniprot id: P31376
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC3 family.
messages: Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.
messages: Nucleus
messages: Present with 1380 molecules/cell in log phase SD medium.

559292:YML078W
gene id: 559292:YML078W
uniprot id: P25719
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: Inhibited by the immunosuppressant drug cyclosporin A and by SDZ NIM811, a PPIase inhibitor.
messages: Mitochondrion matrix
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This isozyme is required for growth on lactate at high temperature.
messages: Present with 1960 molecules/cell in log phase SD medium.

559292:YGR159C
gene id: 559292:YGR159C
uniprot id: P27476
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM GAR family.
messages: In response to low temperature (By cold-shock).
messages: Involved in pre-rRNA processing (PubMed:1644811). Specifically binds nuclear localization sequences (PubMed:1706724). Candidate for a receptor at the nucleus that may be involved in both RNA and protein transport (Probable). Binds telomeric sequences of the type (TG[1-3])n in vitro (PubMed:7800479).
messages: Methylated by HMT1, forming asymmetric dimethylarginines (DMA) within a domain referred to as an RGG box, made up of repeated Gly-Gly dipeptides interspersed with Arg and aromatic residues.
messages: Nucleus
messages: Present with 77400 molecules/cell in log phase SD medium.
messages: Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7) (PubMed:15604408). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:15604408, PubMed:17873058).
messages: nucleolus

559292:YLR114C
gene id: 559292:YLR114C
uniprot id: Q12500
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVL9 family.
messages: Cytoplasm
messages: Functions in the late secretory pathway. Required for the generation of secretory vesicles as well as for actin polarization and polarized growth.
messages: Present with 7500 molecules/cell in log phase SD medium.

559292:YBL095W
gene id: 559292:YBL095W
uniprot id: P38172
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YER182W
gene id: 559292:YER182W
uniprot id: P40098
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP10 family.
messages: Mitochondrion membrane
messages: Present with 1920 molecules/cell in log phase SD medium.

559292:YHR199C
gene id: 559292:YHR199C
uniprot id: P38885
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM18/AIM46 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion
messages: Present with 1350 molecules/cell in log phase SD medium.

559292:YDR338C
gene id: 559292:YDR338C
uniprot id: Q05497
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YNL024C-A
gene id: 559292:YNL024C-A
uniprot id: Q8TGJ3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Kish' means small in Hungarian.
messages: Belongs to the KISH family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Inviable.
messages: Involved in the early part of the secretory pathway.

559292:YMR270C
gene id: 559292:YMR270C
uniprot id: P53437
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRN9 family.
messages: Component of the UAF (upstream activation factor) complex which consists of UAF30, RRN5, RRN9, RRN10, and histones H3 and H4. Interacts with SPT15 and RRN7.
messages: Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
messages: nucleolus

559292:YJR091C
gene id: 559292:YJR091C
uniprot id: P47135
names: Miscellaneous
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YKR013W
gene id: 559292:YKR013W
uniprot id: P36110
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: O-glycosylated.
messages: Secreted
messages: Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.
messages: The SCP domain is necessary and sufficient for lipid export and sterol-binding.

559292:YBR288C
gene id: 559292:YBR288C
uniprot id: P38153
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.
messages: Present with 3410 molecules/cell in log phase SD medium.

559292:YDL134C
gene id: 559292:YDL134C
uniprot id: P23594
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2A subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Exact function not known, phosphatase 2A performs an essential cellular function.
messages: Inactivated in a complex with phosphatase methylesterase PPE1 (PP2Ai). Interacts with phosphatase 2A activator RRD2, which can reactivate PP2Ai by dissociating the catalytic subunit from the complex. Forms a ternary complex with RRD2-TAP42.
messages: Present with 5620 molecules/cell in log phase SD medium.
messages: Reversibly methyl esterified on Leu-369 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.

559292:YDR032C
gene id: 559292:YDR032C
uniprot id: Q12335
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WrbA family.
messages: Present with 2330 molecules/cell in log phase SD medium.
messages: Secreted

559292:YHL018W
gene id: 559292:YHL018W
uniprot id: P38744
names: Miscellaneous
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YLR162W
gene id: 559292:YLR162W
uniprot id: Q06235
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Overexpression confers resistance to the antimicrobial peptide MiAMP1.

559292:YBR161W
gene id: 559292:YBR161W
uniprot id: P38287
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 32 family.
messages: Exhibits a reduction in the synthesis of mannosylated sphingolipids.
messages: Heterodimer of CSH1 and CSG2.
messages: Involved in the synthesis of mannosyl phosphorylinositol ceramide (PubMed:12954640). Catalyzes the addition of mannosyl to phosphorylinositol ceramide (PubMed:12954640).
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YJL026W
gene id: 559292:YJL026W
uniprot id: P09938
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Heterotetramer of two large (R1) and two small (R2) subunits. S.cerevisiae has two different R1 subunits (RNR1 and RNR3) and two different R2 subunits (RNR2 and RNR4). The functional form of the small subunits is a RNR2-RNR4 heterodimer, where RNR2 provides the iron-radical center and RNR4 is required for proper folding of RNR2 and assembly with the large subunits. Under normal growth conditions, the active form of the large subunits is a homodimer of the constitutively expressed RNR1. In damaged cells or cells arrested for DNA synthesis, the reductase consists of multiple species because of the association of the small subunits (RNR2-RNR4) with either the RNR1 homodimer or a heterodimer of RNR1 and the damage-inducible RNR3. Interacts with DIF1.
messages: Induced by DNA-damage.
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center.

559292:YNL265C
gene id: 559292:YNL265C
uniprot id: P53843
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IST1 family.
messages: Cytoplasm
messages: Endosome
messages: Interacts with DID2. Interacts with VPS4 (via MIT domain); the interaction prevents VPS4 oligomerization, competes with the binding of VTA1 to VSP4 and diminishes the ATPase activity of VSP4.
messages: Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole. Regulates the recruitment of VPS4 to the ESCRT-III complex, probably in conjunction with DID2, and VPS4 catalyzes the disassembly of the ESCRT-III complex.
messages: Present with 4760 molecules/cell in log phase SD medium.

559292:YJR134C
gene id: 559292:YJR134C
uniprot id: P47166
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGM1 family.
messages: Golgi apparatus
messages: Interacts with YPT6.
messages: Present with 300 molecules/cell in log phase SD medium.
messages: Required for normal growth rate on galactose and mannose.

559292:YJL140W
gene id: 559292:YJL140W
uniprot id: P20433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a dissociable subcomplex associated with the 10-subunit Pol II core complex. In exponentially proliferating cells, only approximately 20 % of the Pol II complexes contain the RPB4-RPB7 subcomplex. In starving cells, that enter stationary phase, RPB4-RPB7 is associated with Pol II in a stoechiometric manner. The RPB4-RPB7 subcomplex probably associates with TFG1. Interacts with LSM2 and PAT1.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex is necessary for promoter-directed transcription initiation but is not required for recruitment of Pol II to active preinitiation complexes and seems to be dispensable for transcription elongation and termination. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. Involved in DNA repair of damage in the transcribed strand. RPB4 is dispensable under optimal growth conditions, but becomes essential during heat or cold shock and under nutrient depletion. Suppresses the RBP9-mediated transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER) but facilitates the RAD26-mediated TCR subpathway. Under stress conditions only, involved in mRNA export to the cytoplasm. Involved in mRNA decay. Promotes or enhances the deadenylation process of specific mRNAs and may recruit PAT1 and the LSM1-7 complex to these mRNAs, thus stimulating their decapping and further decay.
messages: Nucleus
messages: P-body

559292:YMR194C-B
gene id: 559292:YMR194C-B
uniprot id: Q3E7A9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC4 family.
messages: Mitochondrion intermembrane space
messages: The twin Cx9C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.

559292:YDR381W
gene id: 559292:YDR381W
uniprot id: Q12159
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription/export (TREX) complex, which is at least is formed of SUB2, TEX1 and YRA1 and the THO complex composed of HPR1, MFT1, THO2 and THP1. Interacts with RDS3 and YRA2.
messages: Nucleus
messages: RNA-binding RNA annealing protein. May have a role in pre-mRNA metabolism. Component the TREX complex, which operates in coupling transcription elongation to mRNA export.

559292:YOR127W
gene id: 559292:YOR127W
uniprot id: P39083
names: Function
names: Miscellaneous
messages: GTPase-activating protein (GAP) for CDC42 and/or RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase; acts at a step between the G-protein and the MAP kinase module. Dominant suppressor of bud emergence defect caused by deletion of IPL2/BEM2. Involved in the control of polarized cell growth and proper bud site selection.
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YHL030W
gene id: 559292:YHL030W
uniprot id: P38737
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ECM29 family.
messages: Component of the proteasome. ECM29 binds to both proteasome 19S and 20S particles.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2950 molecules/cell in log phase SD medium.
messages: Stabilizes the proteasome holoenzyme, probably by tethering the 20S proteolytic core particle and the 19S regulatory particle. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

559292:YJR057W
gene id: 559292:YJR057W
uniprot id: P00572
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the thymidylate kinase family.
messages: Catalyzes the conversion of dTMP to dTDP.
messages: Homodimer.
messages: Present with 2980 molecules/cell in log phase SD medium.

559292:YLR155C
gene id: 559292:YLR155C
uniprot id: P0CX77
uniprot id: P0CX78
uniprot id: P0CX79
uniprot id: P0CZ17
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asparaginase 1 family.
messages: Periplasm
messages: Secreted
messages: Subject to nitrogen catabolite repression (NCR). Not found in cells grown on rich nitrogen sources like ammonia, glutamine or glutamate, but is found in cells that have been subjected to nitrogen starvation or have been grown on a poor nitrogen source such as proline.
messages: There are 4 copies for L-asparaginase 2 in yeast. The 4 identical copies ASP3-1, ASP3-2, ASP3-3 and ASP3-4 are arranged in tandem repeats located near a ribosomal DNA cluster.
messages: Yeast contains 2 L-asparaginase isoenzymes: cytoplasmic L-asparaginase I, and cell wall L-asparaginase II.

559292:Q0055
gene id: 559292:Q0055
uniprot id: P03876
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion
messages: This protein is coded in group-II intron 2 of OXI3 (COX1).

559292:YDR085C
gene id: 559292:YDR085C
uniprot id: P33304
names: Function
names: Induction
names: Similarity
messages: Acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.
messages: By pheromone (alpha-factor).
messages: To yeast YER158C.

559292:YPL020C
gene id: 559292:YPL020C
uniprot id: Q02724
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C48 family.
messages: Present with 377 molecules/cell in log phase SD medium.
messages: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SMT3 to its mature form and deconjugation of SMT3 from targeted proteins. Has an essential role in the G2/M phase of the cell cycle.

559292:YDR421W
gene id: 559292:YDR421W
uniprot id: Q04052
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 319 molecules/cell in log phase SD medium.
messages: Transcription activator required for the expression of genes involved in the catabolism of aromatic amino acids such as the aromatic aminotransferase II ARO9 and the phenylpyruvate decarboxylase ARO10.

559292:YBR188C
gene id: 559292:YBR188C
uniprot id: P38302
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NTC complex (or PRP19-associated complex), composed of at least CEF1, CLF1, ISY1, NTC20, SNT309, SYF1, SYF2, and PRP19. The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex (or CEF1-associated complex) reminiscent of a late-stage spliceosome composed also of the U2, U5 and U6 snRNAs and at least BUD13, BRR2, CDC40, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, LEA1, MSL1, PRP8, PRP9, PRP11, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNU114, SPP2, RSE1 and YJU2. Interacts with CEF1, CLF1, ISY1, PRP46, and SYF1.
messages: Involved in pre-mRNA splicing. As a component of the NTC complex, associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation.
messages: Nucleus
messages: Present with 1430 molecules/cell in log phase SD medium.

559292:YOR278W
gene id: 559292:YOR278W
uniprot id: P06174
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the fourth step in the heme biosynthetic pathway.
messages: Present with 1360 molecules/cell in log phase SD medium.
messages: Was originally thought to be involved in mitochondrial import.

559292:YKR003W
gene id: 559292:YKR003W
uniprot id: Q02201
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSBP family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with the AAA ATPase VPS4; regulates OSH6 membrane association. VPS4 is required for membrane dissociation of OSH6.
messages: Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:15173322, PubMed:16156791, PubMed:23934110, PubMed:26206936). Catalyzes the lipid countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM). Specifically exchanges phosphatidylserine (PS) with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the PM in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/PM interface, SAC1 drives PS transport (PubMed:23934110, PubMed:26206936). Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936). Also binds phosphatidic acid (PA) (PubMed:16156791).
messages: Present with 2550 molecules/cell in log phase SD medium.
messages: The OSBP-related domain (ORD) mediates binding of sterols and phospholipids. It displays an incomplete beta-barrel containing a central hydrophobic tunnel that can accommodate a single lipid molecule with a flexible lid covering the tunnel entrance. The ORD can bind two membranes simultaneously. It has at least two membrane-binding surfaces; one near the mouth of the lipid-binding pocket and a distal site that can bind a second membrane. These structural features correlate with the phosphatidylinositol 4-phosphate (PI(4)P)-coupled lipid transport optimized in closely apposed membranes, such as organelle contact sites. The lipid transfer cycle starts from the association of the LTP with a donor membrane, which accompanies conformational changes that uncover the ligand-binding pocket. The tunnel opening is generally mediated by displacement of the lid covering the binding pocket allowing uptake or release of a lipid molecule. The LTPs extract the lipid from the membrane by providing a hydrophobic environment as well as specific interaction. Dissociation from the donor membrane shifts the conformation to a closed form. Then, the LTPs loaded with a cargo lipid diffuse through the aqueous phase. Lid opening may be induced by the interaction of a hydrophobic side of the lid with the target membranes.

559292:YFL053W
gene id: 559292:YFL053W
uniprot id: P43550
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

559292:YHR154W
gene id: 559292:YHR154W
uniprot id: P38850
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex with the cullin-RING ligase (CRL) RTT101(MMS1-MMS22). Interacts with MMS22 and RTT101. Interacts with histone H2A; requires H2A to be phosphorylated (gamma-H2A). Interacts with RAD55.
messages: Nucleus
messages: Phosphorylated by MEC1.
messages: Present with 1380 molecules/cell in log phase SD medium.
messages: Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.

559292:YDR364C
gene id: 559292:YDR364C
uniprot id: P40968
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: May function in the second step of pre-mRNA splicing. Regulatory protein involved in replication and mitotic spindle formation and/or maintenance. Required for initiation and completion of S-phase and for initiation and completion of DNA replication. Might be required for the maintenance of microtubules. Essential only at elevated temperatures.
messages: Nucleus
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YER179W
gene id: 559292:YER179W
uniprot id: P25453
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RecA family. DMC1 subfamily.
messages: Double stacked ring-shaped homooctamer (By similarity). Forms a ternary complex with MEI5 and SAE3. Interacts with RDH54.
messages: Expressed 2.5 hours after induction of meiosis.
messages: Nucleus
messages: Required for meiotic recombination, synaptonemal complex formation and cell cycle progression. Recruited to meiosis recombination hotspots by MEI5 and SAE3.

559292:YOR261C
gene id: 559292:YOR261C
uniprot id: Q08723
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.
messages: N-acetylated by NAT1.
messages: Present with 19800 molecules/cell in log phase SD medium.

559292:YCR087C-A
gene id: 559292:YCR087C-A
uniprot id: P37263
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0743 family.
messages: Present with 3430 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YHR134W
gene id: 559292:YHR134W
uniprot id: P38838
names: Activity Regulation
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulates DPCs and exhibits gross chromosomal rearrangements.
messages: Belongs to the peptidase M3 family. WSS1-like metalloprotease (WLM) subfamily.
messages: Binds to DNA. Interacts with CDC48 and SMT3. Interacts with PSY2 and TOF1.
messages: Inactivated by EDTA.
messages: Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
messages: Nucleus
messages: The SHP box and the VCP-interaction motif (VIM) are important both together for binding to CDC48. The 2 SUMO interaction motifs (SIM) are each important for binding to SMT3(SUMO).
messages: Was initially reported to be a SUMO-dependent isopeptidase (PubMed:20516210), but this activity could not be confirmed (PubMed:24998930).

559292:YLR100W
gene id: 559292:YLR100W
uniprot id: Q12452
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3-keto-steroid reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:10535978, PubMed:12119386, PubMed:12842197, PubMed:15995173). ERG27 is a catalytic component of the C-4 demethylation complex that catalyze the reduction of the keto group on the C-3 (PubMed:10535978). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo …
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
messages: Endoplasmic reticulum membrane
messages: Facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles.
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25 and ERG28. Also interacts with ERG7, but only in lipid particles.
messages: Lipid droplet

559292:YNR048W
gene id: 559292:YNR048W
uniprot id: P53740
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC50/LEM3 family.
messages: Interacts with DNF3; interaction is required for proper expression and endoplasmic reticulum (ER) export of either partner.
messages: Potential non-catalytic subunit for a heteromeric phospholipid translocase (PLT) CRF1-DNF3, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs CDC50-DRS2 and LEM3-DNF1/2. May be involved in transport from early endosomes to the trans-Golgi network (TGN).
messages: Present with 4510 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YNL204C
gene id: 559292:YNL204C
uniprot id: P32572
names: Caution
names: Developmental Stage
messages: It is uncertain whether Met-1 or Met-10 is the initiator.
messages: Sequentially activated during the process of meiosis and spore formation.

559292:YKL113C
gene id: 559292:YKL113C
uniprot id: P26793
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA (POL30). Three molecules of RAD27 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Present with 6120 molecules/cell in log phase SD medium.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

559292:YOR259C
gene id: 559292:YOR259C
uniprot id: P53549
names: Function
names: PTM
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: N-acetylated by NAT1.
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

559292:YML007W
gene id: 559292:YML007W
uniprot id: P19880
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. YAP subfamily.
messages: Contains two cysteine rich domains (CRD), referred to as the N- and C-terminal CRD's, n-CRD (Cys-303, Cys-310 and Cys-315) and c-CRD (Cys-598, Cys-620 and Cys-629), respectively. Cys-315 is not conserved in orthologs in other yeast species. A nuclear export signal is embedded in the c-CRD, with which the nuclear export protein CRM1/exportin 1 interacts only in the absence of disulfide bonds (or otherwise oxidized cysteines) within the c-CRD or between the c-CRD and the n-CRD.
messages: Cytoplasm
messages: Depending on the oxidative stress inducing agent, YAP1 can undergo two distinct conformational changes, both involving disulfide bond formation, and both masking the nuclear export signal, thus abolishing nuclear export by CRM1/exportin 1. The disulfide stress-inducing agent diamide leads to the formation of one of three possible disulfide bonds in the c-CRD. Peroxide stress induces the formation of the HYR1/GPX3- and YBP1-dependent interdomain disulfide bond between Cys-303 and Cys-598 (causing nuclear localization of YAP1), and the possibly stabilizing bond between Cys-310 and Cys-629 (required for full activity of YAP1).
messages: Interacts independent of oxidation state in the cytoplasm with the karyopherin PSE1/KAP121 (and less strongly with KAP123). The reduced form of YAP1 interacts in the nucleus with the nuclear export protein CRM1, and in the cytoplasm with YBP1 and the peroxiredoxin HYR1/GPX3/ORP1. Interacts with RBG1.
messages: Nucleus
messages: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
messages: Present with 1600 molecules/cell in log phase SD medium.
messages: Transcription activator involved in oxidative stress response and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways, including the thioredoxin system (TRX2, TRR1), the glutaredoxin system (GSH1, GLR1), superoxide dismutase (SOD1, SOD2), glutathione peroxidase (GPX2), and thiol-specific peroxidases (TSA1, AHP1). The induction of some of these genes requires the cooperative action of both, YAP1 and SKN7. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress (as well as carbon stress, but not increased temperature, acidic pH, or ionic stress) induces nuclear accumulation and as a result YAP1 transcriptional activity. Activation by hydrogen peroxide or thiol-reactive chemicals elicit distinct adaptive gene responses. Nuclear export is restored when disulfide bonds are reduced by thioredoxin (TRX2), whose expression is controlled by YAP1, providing a mechanism for negative autoregulation. When overexpressed, YAP1 confers pleiotropic drug-resistance and increases cellular tolerance to cadmium, iron chelators and zinc.
messages: YAP1 expression is at least partially regulated at the level of translation. A small upstream open reading frame (uORF) retains the 40S ribosomal subunit. By leaky scanning it then proceeds and reinitiates at the functional YAP1 ORF.

559292:YMR027W
gene id: 559292:YMR027W
uniprot id: Q04371
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Activity is strongly promoted by Co(2+), Ni(2+) and Mn(2+) (PubMed:27322068). Activity is inhibited by EDTA (PubMed:27322068).
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Expression is up-regulated in response to treatment with the DNA-damaging agent methyl methanesulfonate (MMS).
messages: Leads to the accumulation of fructose-1-phosphate (PubMed:27322068). Leads to increased DNA damage or decreased repair (PubMed:18085829).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (PubMed:27322068). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (PubMed:27322068).
messages: Phosphatase activity is strongly promoted by several divalent cations but it is suggested that Mn(2+) and possibly Ni(2+) represent biologically relevant metal ion cofactors for damage-control phosphatases.
messages: Present with 6190 molecules/cell in log phase SD medium.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

559292:YBL088C
gene id: 559292:YBL088C
uniprot id: P38110
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Interacts with XRS2 and associates with DNA double-strand breaks.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited by the MRX-complex to sites of DNA lesions immediately after damage to initiate non-homologous end-joining (NHEJ). Subsequently displaced by the RPA complex in a reaction probably involving the SAE2 protein. Phosphorylates MRE11 and XRS2, 2 subunits of the MRX-complex. The phosphorylation of MRE11 is a feedback response from the checkpoint signaling pathway. Phosphorylates RAD9, CHK1 and RAD53, leading to the activation of the CHK1 and RAD23 kinases involved in the DNA damage response cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are involved in genome stability. Required for the control of telomere length and genome stability.
messages: telomere

559292:YKL167C
gene id: 559292:YKL167C
uniprot id: P32388
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL61 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543). mL61 is not essential in cells grown at 30 degree Celsius but is required for mitochondrial translation in cells grown at 18 degree Celsius.
messages: Mitochondrion

559292:YDR409W
gene id: 559292:YDR409W
uniprot id: Q04195
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance.
messages: Autosumoylated upon ethanol stress.
messages: Belongs to the PIAS family.
messages: Bud neck
messages: Cytoplasm
messages: Interacts with UBC9 and CDC3.
messages: Nucleus
messages: Phosphorylated in early M-phase.
messages: Present with 149 molecules/cell in log phase SD medium.
messages: The SAP domain is required for nuclear targeting.
messages: The SP-RING-type zinc finger mediates interaction with UBC9 and CDC3 and is required for E3 activity.

559292:YPR091C
gene id: 559292:YPR091C
uniprot id: Q06833
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, induces contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: Present with 36500 molecules/cell in log phase SD medium.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

559292:YHL050C
gene id: 559292:YHL050C
uniprot id: P38721
names: Subcellular Location Annotation
messages: Membrane

559292:YOR273C
gene id: 559292:YOR273C
uniprot id: Q12256
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
messages: By transcription factor HAA1 in response to acetaldehyde accumulation.
messages: Cell membrane
messages: Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermidine, spermine and the antimalarial drug quinidine, but not quinine, chloroquine and mefloquine.
messages: Present with 21400 molecules/cell in log phase SD medium.

559292:YIL169C
gene id: 559292:YIL169C
uniprot id: P40442
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Decreases haze protective activity in white wine.
messages: Expression is induced in both high and low pH environments.
messages: Secreted
messages: Secreted protein that may be involved in cell wall organization and biosynthesis.

559292:YJL014W
gene id: 559292:YJL014W
uniprot id: P39077
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

559292:YGR214W
gene id: 559292:YGR214W
uniprot id: P32905
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS2 is required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (PubMed:9973221, PubMed:14627813).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 93700 molecules/cell in log phase SD medium.
messages: Reduction in growth rate, a decrease in free 40S subunits, an increase in the amount of free 60S subunits and a decrease in polysome size.
messages: There are 2 genes for uS2 in yeast.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. This protein does not bind laminin.

559292:YBL080C
gene id: 559292:YBL080C
uniprot id: P33893
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Present with 1390 molecules/cell in log phase SD medium.
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A (HER2), B (PET112) and F (YGR102C) subunits.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

559292:YHL046C
gene id: 559292:YHL046C
uniprot id: P38725
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YML030W
gene id: 559292:YML030W
uniprot id: Q03713
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor that plays a role in the assembly of the respiratory chain supercomplexes (SCs) composed of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV). Involved in the recruitment of COX13 and RCF2 into cytochrome c oxidase. May also be required for late-stage assembly of the COX12 and COX13 subunits (PubMed:22342701, PubMed:22405070, PubMed:22310663). Required for the generation and maintenance of a normal proton motive force (PMF) across the inner mitochondrial membrane (IMM) by preventing proton leakage through an inactive population of CIV that accumulates when RCF1 and/or RCF2 proteins are absent (PubMed:30683696, PubMed:31591265).
messages: Associates with a subpopulation of the cytochrome bc1-cytochrome c oxidase supercomplexes (PubMed:19750512, PubMed:22342701, PubMed:22405070, PubMed:22310663). Associates in substoichiometric amounts with complex IV (PubMed:22310663). Interacts with COX3 (PubMed:22310663).
messages: Belongs to the AIM31 family.
messages: Increases frequency of mitochondrial genome loss. Promotes reactive oxygen species (ROS) generation.
messages: Mitochondrion membrane
messages: Present with 1210 molecules/cell in log phase SD medium.

559292:YOR142W-B
gene id: 559292:YOR142W-B
uniprot id: Q92393
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YOR142W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YNL214W
gene id: 559292:YNL214W
uniprot id: P40155
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Component of the peroxisomal translocation machinery with PEX13 and PEX14. Interacts indirectly with the PTS1 receptor (PAS10/PEX5) and directly binds to PEX14. Required for import of both PTS1 and PTS2 proteins.
messages: Peroxisome membrane
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YDL063C
gene id: 559292:YDL063C
uniprot id: Q07395
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a heterotrimeric complex with RPL5 and RPL11A or RPL11B. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer.
messages: Nuclear import adapter that specifically recruits the two functionally and topologically linked ribosomal proteins RPL5 and RPL11 (encoded by RPL11A and RPL11B). Guarantees that this cargo pair remains bound together from the time of synthesis in the cytoplasm until delivery to the nascent 5S rRNA in the nucleus.
messages: Nucleus
messages: Present with 2600 molecules/cell in log phase SD medium.

559292:YHL022C
gene id: 559292:YHL022C
uniprot id: P23179
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOP6A family.
messages: Chromosome
messages: Meiosis-specific.
messages: Nucleus
messages: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The action of SPO11 is important in setting off a regulatory chain of events encompassing 5' to 3' resection. When there are no SPO11-DSBs, resection of a site specific VDE-DSB takes place but it is faster than in wild-type meiosis and increases the risk of uncovering flanking homology.

559292:YIL051C
gene id: 559292:YIL051C
uniprot id: P40185
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Mitochondrion matrix
messages: Plays a role in the maintenance of mitochondrial DNA.
messages: Present with 168000 molecules/cell in log phase SD medium.

559292:YJR100C
gene id: 559292:YJR100C
uniprot id: P47140
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipid scramblase family.
messages: Mitochondrion

559292:YGL201C
gene id: 559292:YGL201C
uniprot id: P53091
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Required for the entry in S phase and for cell division.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer. Interacts with MCM10.
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus
messages: Present with 13400 molecules/cell in log phase SD medium.

559292:YPR106W
gene id: 559292:YPR106W
uniprot id: Q06098
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Present with 1590 molecules/cell in log phase SD medium.
messages: Probable serine/threonine protein kinase which may function redundantly with MPK1-independent branch of the PCK1 pathway that is presumed to be required for the tolerance to high temperatures and staurosporine.

559292:YDR270W
gene id: 559292:YDR270W
uniprot id: P38995
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles.
messages: trans-Golgi network membrane

559292:YBR066C
gene id: 559292:YBR066C
uniprot id: P38082
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 704 molecules/cell in log phase SD medium.
messages: Transcriptional repressor.

559292:YDR345C
gene id: 559292:YDR345C
uniprot id: P32466
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.
messages: Low-affinity glucose transporter.
messages: Membrane
messages: Present with 37200 molecules/cell in log phase SD medium.
messages: Repressed at high glucose concentrations.

559292:YOR211C
gene id: 559292:YOR211C
uniprot id: P32266
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cleavage of the transit peptide by mitochondrial processing protease (MPP) produces a long integral membrane form of MGM1 (l-MGM1). Further processing by the rhomboid protease PCP1 produces a short peripheral membrane form of MGM1 (s-MGM1). Both isoforms are required for full activity.
messages: Deletion of MGM1 causes the mitochondria to fragment and aggregate, and subsequently to lose their mitochondrial DNA and become respiration deficient.
messages: Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane.
messages: Homooligomer. Associates with FZO1 through interaction with the intermembrane space domain of UGO1 which binds FZO1 through its cytoplasmic domain.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

559292:YHR123W
gene id: 559292:YHR123W
uniprot id: P22140
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the final step in the CDP-ethanolamine route leading to phosphatidylethanolamine (PE). Can also catalyze the formation of phosphatidylcholine (PC) from CDP-choline, but does not substantially contribute to PC biosynthesis. Preferentially uses CDP-dimethylethanolamine and CDP-propanolamine as aminoalcohol substrates. Shows highest activity toward di-unsaturated diacylglycerol species as lipid substrates. The CDP-ethanolamine pathway may play a role in maintaining the proper PE species distribution.
messages: Golgi apparatus membrane
messages: Repressed by inositol. Repression is dependent on the presence of CPT1.
messages: Requires a divalent cation activator, and is inhibited by CMP. Activated by phospholipids, especially phosphatidylcholine.

559292:YDR256C
gene id: 559292:YDR256C
uniprot id: P15202
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Homotetramer.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome
messages: Present with 623 molecules/cell in log phase SD medium.
messages: This is one of two catalases in S.cerevisiae; the other is catalase T, which is the cytoplasmic form.

559292:YLR273C
gene id: 559292:YLR273C
uniprot id: Q06216
names: Function
messages: Regulates the activity of glycogen synthase. It is most probably a regulatory subunit for protein phosphatase type 1.

559292:YML040W
gene id: 559292:YML040W
uniprot id: P0CX74
uniprot id: P0CX75
uniprot id: P0CX76
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-JR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR3 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ML2 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YDR394W
gene id: 559292:YDR394W
uniprot id: P33298
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: N-acetylated by NAT3.
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

559292:YFL051C
gene id: 559292:YFL051C
uniprot id: P43552
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To yeast protein FLO1.

559292:YKL040C
gene id: 559292:YKL040C
uniprot id: P32860
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NifU family.
messages: Cells are impaired in growth on synthetic complete medium with acetate as a carbon source due to defects in mitochondrial [4Fe-4S] cluster formation.
messages: Homodimer; in absence of BOL3, probably bridged by an iron-sulfure cluster (PubMed:27532773). Interacts with BOL3 (PubMed:27532773). Interacts with apo-target proteins, such as ACO1, LYS4, ACO2 and SDH2 (PubMed:27532773).
messages: Involved in iron homeostasis within the mitochondrion where it is involved in the assembly of iron-sulfur proteins (PubMed:10468587, PubMed:27532773). Together with BOL3, required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532773). Required for protecting iron sulfur clusters from oxidative damage (PubMed:27532773).
messages: Mitochondrion matrix
messages: Present with 11300 molecules/cell in log phase SD medium.
messages: The CxxC motif may bind a [4Fe-4S] cluster.

559292:YBR022W
gene id: 559292:YBR022W
uniprot id: P38218
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the POA1 family.
messages: Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose.
messages: Present with 1170 molecules/cell in log phase SD medium.

559292:YLR099W-A
gene id: 559292:YLR099W-A
uniprot id: Q3E798
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIM2 family.
messages: Causes severe growth phenotype and leads to reduced biogenesis of mitochondrial proteins and abnormal mitochondrial morphology (PubMed:22467864). Compromises import of multispan mitochondrial outer membrane (MOM) proteins (PubMed:22467864).
messages: Component of the MIM complex containing at least MIM1 and MIM2 (PubMed:22467864). Interacts with MIM1; interaction is direct (PubMed:22467864).
messages: Component of the MIM complex required for outer membrane protein import (PubMed:22467864). Involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including UGO1, TOM20 and FZO1 (PubMed:22467864).
messages: Mitochondrion outer membrane

559292:YBR056W
gene id: 559292:YBR056W
uniprot id: P38081
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
messages: Mitochondrion intermembrane space
messages: Present with 1960 molecules/cell in log phase SD medium.

559292:YAL016W
gene id: 559292:YAL016W
uniprot id: P31383
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit A family.
messages: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
messages: PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit (PR65) (subunit A). The core complex associates with a third, variable subunit (subunit B), which confers distinct properties to the holoenzyme.
messages: Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.
messages: Present with 16900 molecules/cell in log phase SD medium.

559292:YAR003W
gene id: 559292:YAR003W
uniprot id: P39706
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the COMPASS (Set1C) complex which consists of SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and SWD3(1).
messages: Nucleus
messages: Present with 907 molecules/cell in log phase SD medium.
messages: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: telomere

559292:YNL310C
gene id: 559292:YNL310C
uniprot id: P42844
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: By heat shock (at protein level).
messages: Interacts with SSC1; binds to the nucleotide-free state as well as to the ADP- or ATP-bound state of SSC1.
messages: Involved in protein import into mitochondria. Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis. May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:YPR116W
gene id: 559292:YPR116W
uniprot id: Q06109
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG8 family.
messages: Decrease in plasma membrane electron transport.
messages: Mitochondrion
messages: Present with 2140 molecules/cell in log phase SD medium.
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

559292:YDR320C
gene id: 559292:YDR320C
uniprot id: Q06677
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cofactor for the uncoating of clathrin-coated vesicles (CCVs) by Hsp70-type chaperones (SSA1/2/3 and SSB1/2). Coat disassembly is important for fusion of vesicles with target membranes and for recycling components of clathrin coats to the cytoplasm for further rounds of vesicle formation. Binds to assembled clathrin and recruits the ATP-activated chaperone to CCVs. Stimulates the ATPase activity of the clathrin-associated Hsp70-type chaperone SSA1, which then disrupts clathrin-clathrin interactions, leading to release of the clathrin coat. In addition, prevents unproductive clathrin assembly in the cell. Also required for cortical endoplasmic reticulum inheritance.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with the clathrin light and heavy chains CLC1 and CHC1, respectively. Binds to clathrin with its N-terminal domain containing 3 clathrin-binding (CB) motifs. Association with clathrin is transient. Binds to polyubiquitin and ubiquitinated proteins.
messages: Present with 768 molecules/cell in log phase SD medium.
messages: The TPR repeats and the J domain are required for interaction with Hsp70-type chaperones. The J domain is responsible for stimulating the ATPase activity of the chaperone.

559292:YKR017C
gene id: 559292:YKR017C
uniprot id: P36113
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RBR family.
messages: Interacts with the E2 ubiquitin-conjugating enzyme UBC4 and histones H3 and H4.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: Present with 2250 molecules/cell in log phase SD medium.
messages: Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.

559292:YHR017W
gene id: 559292:YHR017W
uniprot id: P32792
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0744 family.
messages: Mitochondrion outer membrane

559292:YDL086W
gene id: 559292:YDL086W
uniprot id: Q07505
names: Similarity
messages: Belongs to the dienelactone hydrolase family.

559292:YJL210W
gene id: 559292:YJL210W
uniprot id: P32800
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:19687296, PubMed:22471590, PubMed:35768507). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (PubMed:35768507). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (PubMed:35768507).
messages: Peroxisome membrane
messages: Present with 339 molecules/cell in log phase SD medium.
messages: The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore (By similarity). The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex (By similarity).

559292:YOR209C
gene id: 559292:YOR209C
uniprot id: P39683
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:9521740). Essential for growth under anaerobic conditions (PubMed:12062417).
messages: Cytoplasm
messages: Nucleus
messages: Present with 32100 molecules/cell in log phase SD medium.
messages: Transiently phosphorylated on a His residue during the reaction cycle (By similarity). Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production (PubMed:9521740). Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release (By similarity).

559292:YPL174C
gene id: 559292:YPL174C
uniprot id: P33420
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the dynactin complex composed of at least ARP1, JNM1, NIP100 and ARP10. Dynactin comprises a short rod of the ARP1 filament attached to ARP10 at its pointed-end and probably associated with the capping protein at its barbed-end. The rod is implicated in dynein cargo binding. A sidearm formed by NIP100 projects from the ARP1 filament and is implicated in motor binding (By similarity).
messages: Cytoplasm
messages: Motor-binding component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint.
messages: Present with 238 molecules/cell in log phase SD medium.
messages: cytoskeleton
messages: spindle pole

559292:YJL126W
gene id: 559292:YJL126W
uniprot id: P47016
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
messages: Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione (PubMed:28373563). Possesses amidase activity toward deaminated ophthalmate in vitro (PubMed:28373563).
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion

559292:YJR150C
gene id: 559292:YJR150C
uniprot id: P47178
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall.
messages: Extensively O-glycosylated.
messages: Induced during anaerobic growth and completely repressed during aerobic growth.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YDR218C
gene id: 559292:YDR218C
uniprot id: Q04921
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Expressed during meiosis and ascospore formation. First expressed at the beginning of meiosis I, and is highly expressed prior meiosis II.
messages: Interacts with itself. Interacts with CDC11 and SPR3; probably to form a ring at the bud neck.
messages: Membrane
messages: Septins are GTPases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity).

559292:YER121W
gene id: 559292:YER121W
uniprot id: P40076
names: Function
messages: May be involved in phosphatase regulation and/or generation of precursor metabolites and energy.

559292:YIL149C
gene id: 559292:YIL149C
uniprot id: P40457
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear complex (NPC) (PubMed:24152732). NPC constitutes the exclusive means of nucleocytoplasmic transport (PubMed:24152732). NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope (PubMed:24152732). Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof (PubMed:24152732). Interacts with NUP60 and NIC96, which tether it to the nuclear pore complex. Component of the spindle pole body core in which it interacts directly with SPC110, SPC42 and SPC29. Also interacts with YKU70 (HDF1) and MLP1.
messages: Nucleus
messages: Present with 2770 molecules/cell in log phase SD medium.
messages: Together with the closely related MLP1, involved in the structural and functional organization of perinuclear chromatin (PubMed:10638763). MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery (PubMed:10085285, PubMed:24152732, PubMed:10617624). Has a role in the localization of Esc1 to nucleolar regions (PubMed:24152732). Together with MLP1, mediates tethering of the some telomeres to the nuclear periphery, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing (PubMed:11862215). MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring (PubMed:12490156). Plays a role in the incorporation of components into the spindle pole body (PubMed:10617624, PubMed:14718167, PubMed:16027220). Involved in double-strand break repair, probably also mediated by the YKU70/YKU80 (HDF1/HDF2) heterodimer (PubMed:10638763, PubMed:14718167, PubMed:16027220).
messages: nuclear pore complex
messages: spindle pole body

559292:YPL033C
gene id: 559292:YPL033C
uniprot id: Q03085
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expression is induced by the KAR4 transcription factor.
messages: May be involved in the regulation of dNTP production. Induces the SOS system when expressed in E.coli, therefore, it may play a role in DNA metabolism and/or in genome stability.
messages: Related to oxidoreductases, but misses the conserved Thr active site. Therefore it may not have any oxidoreductase activity.
messages: Suppresses the lethality of LCD1 and RAD53 mutations. Leads to resistance to the chemicals that inhibit nucleotide metabolism and increases dNTP levels in the presence of hydroxyurea.

559292:YPL267W
gene id: 559292:YPL267W
uniprot id: Q08981
names: Function
names: Induction
names: Miscellaneous
names: Subunit
messages: Expressed very quickly after G1 release, just prior to initiation of DNA replication.
messages: Interacts with CDH1, BMH1 and BMH2.
messages: Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.
messages: Present with 688 molecules/cell in log phase SD medium.

559292:YPR191W
gene id: 559292:YPR191W
uniprot id: P07257
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Does not seem to have protease activity as it lacks the zinc-binding site.
messages: Mitochondrion inner membrane
messages: Present with 35700 molecules/cell in log phase SD medium.

559292:YMR325W
gene id: 559292:YMR325W
uniprot id: P0CE85
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YOR219C
gene id: 559292:YOR219C
uniprot id: P33894
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family.
messages: Responsible for the proteolytic maturation of the alpha-factor precursor.
messages: Vacuole membrane

559292:YDL233W
gene id: 559292:YDL233W
uniprot id: Q07684
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MFG1 family.
messages: Interacts with FLO8 and MSS11, both morphogenetic transcription factors binding directly to the FLO11 promoter.
messages: Nucleus
messages: Present with 1010 molecules/cell in log phase SD medium.
messages: Transcriptional regulator with a general role in all morphogenetically distinct forms of filamentous growth, namely haploid invasive growth, biofilm formation, and diploid pseudohyphal growth. May control FLO11 gene expression as part of a promoter-bound complex with FLO8 and MSS1.

559292:YDL017W
gene id: 559292:YDL017W
uniprot id: P06243
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Associates with DBF4 and ORC2.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
messages: Present with 1600 molecules/cell in log phase SD medium.
messages: Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression.

559292:YNL073W
gene id: 559292:YNL073W
uniprot id: P32048
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of lysine to tRNA(Lys) in the mitochondrion.
messages: Mitochondrion matrix
messages: Present with 2280 molecules/cell in log phase SD medium.

559292:YOR205C
gene id: 559292:YOR205C
uniprot id: Q08622
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
messages: Increases frequency of mitochondrial genome loss.
messages: Interacts genetically with prohibitins and thus may be involved in the mitochondrial lipid metabolism.
messages: Mitochondrion
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YLR220W
gene id: 559292:YLR220W
uniprot id: P47818
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Deletion causes an increase in metal sensitivity at 15 mM manganese, but does not affect invertase glycosylation. Deletion shows increased sensitivity to external iron, which is suppressed by MRS3 or MRS4 overexpression requiring oxygen but not respiration, and exacerbated by ectopic expression of the iron transporter FET4. Deletion also results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth. Deletion together with MRS3 and MRS4 restores cellular and mitochondrial iron homeostasis to near normal level, corrects the MRS3 and MRS4 double deletion phenotype (which shows increased resistance to cobalt but decreased resistance to copper and cadmium), and has near normal levels of aconitase activity. When overexpressed, maintains respiratory function in a YFH1 deletion mutant regardless of extracellular iron concentration, activates the iron-dependent transcription factor AFT1 resulting in an increase in iron uptake, cytosolic iron accumulation and a change in copper metabolism. Overexpression prevents excessive mitochondrial iron accumulation by limiting mitochondrial iron uptake and results in increased expression of the high affinity iron transport system composed of FET3 and FTR1. Overexpression also suppresses the rapamycin-resistant phenotype of PMR1 deletion mutant.
messages: Down-regulated under iron starvation by TIS11. Transcriptionally up-regulated by YAP5 in response to increased cytosolic iron.
messages: Golgi apparatus membrane
messages: Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals.
messages: Present with 2840 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YMR192W
gene id: 559292:YMR192W
uniprot id: Q04322
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GYP5 family.
messages: Bud
messages: Bud neck
messages: Cytoplasm
messages: Interacts with GYP5 and RVS167. Is part of SEC4-containing complexes.
messages: Present with 2010 molecules/cell in log phase SD medium.
messages: Probable GTPase-activating protein which stimulates the GTP hydrolysis rate by GYP5 of YPT1 and SEC4. Involved in ER to Golgi trafficking and polarized exocytosis.

559292:YDL208W
gene id: 559292:YDL208W
uniprot id: P32495
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) (PubMed:21708174, PubMed:9843512, PubMed:9848653, PubMed:21131909). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10 (PubMed:21708174, PubMed:9843512, PubMed:9848653, PubMed:21131909). The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind (PubMed:21708174, PubMed:9843512, PubMed:9848653, PubMed:21131909). Interacts with SHQ1 (PubMed:12228251). Interacts with NAF1 (PubMed:12515383).
messages: Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512, PubMed:9848653). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512, PubMed:9848653). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512, PubMed:9848653). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9843512). Directly binds H/ACA snoRNAs (PubMed:11433018).
messages: nucleolus

559292:YJL042W
gene id: 559292:YJL042W
uniprot id: P43638
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Essential for the formation and/or stabilization of microtubules. Binds to microtubules in vitro.
messages: Present with 279 molecules/cell in log phase SD medium.
messages: spindle

559292:YMR298W
gene id: 559292:YMR298W
uniprot id: Q03579
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LIP1 family.
messages: Component of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.
messages: Component of the ceramide synthase complex required for synthesis of ceramides.
messages: Endoplasmic reticulum membrane

559292:YGL122C
gene id: 559292:YGL122C
uniprot id: P32505
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB2 family.
messages: Contains seven CCCH Zn fingers that bind to A-rich RNAs and fingers 5 to 7 are critical for these function (PubMed:12496292, PubMed:22560733, PubMed:28180315). Binding A(11)G RNA induces dimerization of Zn fingers 5-7 mediated by the spatial arrangement of the fingers promoting each RNA chain binding two protein chains (PubMed:28180315).
messages: Cytoplasm
messages: Essential protein that binds to polyadenylated RNA and single-stranded DNA (PubMed:8474438). It may be involved not only in RNA processing but also in transcription regulation. Associates directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions (Probable). Involved in mRNA poly(A) tail length control and nuclear export (PubMed:11927564, PubMed:11779864). Functions in surveillance and the packaging leading to generation of export-competent mRNPs. Controls both mRNP compaction that facilitates movement through nuclear pore complexes and the length of transcript poly(A) tails (PubMed:19840948, PubMed:22560733).
messages: Interacts with MLP1.
messages: Methylated by HMT1.
messages: Nucleus
messages: Present with 9670 molecules/cell in log phase SD medium.
messages: The N-terminal domain is required for nuclear export of both poly(A) RNA and NAB2.
messages: The RGG domain is important for NAB2 import.

559292:YER034W
gene id: 559292:YER034W
uniprot id: P40022
names: Miscellaneous
messages: Present with 1100 molecules/cell in log phase SD medium.

559292:YER069W
gene id: 559292:YER069W
uniprot id: Q01217
names: Activity Regulation
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the NAGSA dehydrogenase family.
messages: In the N-terminal section; belongs to the acetylglutamate kinase family.
messages: Mitochondrion
messages: Present with 1180 molecules/cell in log phase SD medium.
messages: The kinase activity is inhibited by arginine.
messages: The protein precursor is cleaved into the two biologically active enzymes, the kinase and the reductase.

559292:YGR065C
gene id: 559292:YGR065C
uniprot id: P53241
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Allantoate permease family.
messages: Cell membrane
messages: Involved in uptake of biotin with the concomitant entry of protons.

559292:YML008C
gene id: 559292:YML008C
uniprot id: P25087
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes the production of ergosterol.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
messages: Interacts with ERG28.
messages: Microsome
messages: Mitochondrion
messages: Present with 53800 molecules/cell in log phase SD medium.
messages: Sterol 24-C-methyltransferase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:6363386). ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol (PubMed:6363386). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto …

559292:YPL093W
gene id: 559292:YPL093W
uniprot id: Q02892
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with nucleolar and cytoplasmic pre-60S particles. Directly interacts with RLP24.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: Present with 28000 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YIL151C
gene id: 559292:YIL151C
uniprot id: P40456
names: Function
names: Miscellaneous
messages: May be involved in the regulation of gene expression responses of environment-sensing pathways.
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YCR097W
gene id: 559292:YCR097W
uniprot id: P0CY11
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MATA1 family.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of A1 at HMR.
messages: Nucleus
messages: There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.
messages: There is no sequence for the expressed copy of A1 in strain S288c, because this strain is of mating type alpha. A sequence for the expressed copy of A1 can be found in other strains (AC P0CY10).

559292:YOL036W
gene id: 559292:YOL036W
uniprot id: Q08206
names: PTM
messages: Phosphorylated by CDC28.

559292:YER083C
gene id: 559292:YER083C
uniprot id: P40056
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GET2 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function.

559292:YMR076C
gene id: 559292:YMR076C
uniprot id: Q04264
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acetylated by ECO1.
messages: Belongs to the PDS5 family.
messages: Essential for the establishment and maintenance of sister chromatid cohesion at centromere proximal and distal regions during S phase. Also required for chromosomal condensation.
messages: Nucleus
messages: Present with 7720 molecules/cell in log phase SD medium.

559292:YDL029W
gene id: 559292:YDL029W
uniprot id: P32381
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP2 subfamily.
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.
messages: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
messages: Present with 6650 molecules/cell in log phase SD medium.
messages: actin patch

559292:YPL110C
gene id: 559292:YPL110C
uniprot id: Q02979
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Affects the glycerophosphocholine metabolism but not the glycerophosphoinositol metabolism (PubMed:16141200).
messages: Belongs to the GDE1 family.
messages: Cytoplasm
messages: Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline (PubMed:16141200, PubMed:16172116). The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source (PubMed:16141200). May also use glycerophosphoinositol as substrate in vivo (PubMed:16172116).
messages: Present with 2300 molecules/cell in log phase SD medium.

559292:YGL189C
gene id: 559292:YGL189C
uniprot id: P39938
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS26 interacts with eS1 forming part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102). eS26 interacts with TSR2 (PubMed:10688190, PubMed:12837249).
messages: Cytoplasm
messages: Present with 16300 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS26 in yeast.

559292:YPL232W
gene id: 559292:YPL232W
uniprot id: P32867
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Present with 450 molecules/cell in log phase SD medium.
messages: Required for vesicle fusion with the plasma membrane.

559292:YJL155C
gene id: 559292:YJL155C
uniprot id: P32604
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Inhibited by fructose 6-P, activated by glycerol 3-P.
messages: Monofunctional, high-specificity fructose-2,6-bisphosphatase, which releases phosphate from the 2-position of fructose 2,6-bisphosphate. Has no detectable 6-phosphofructo-2-kinase activity.
messages: Present with 1680 molecules/cell in log phase SD medium.

559292:YHR110W
gene id: 559292:YHR110W
uniprot id: P38819
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Involved in vesicular protein trafficking.

559292:YBR225W
gene id: 559292:YBR225W
uniprot id: P38321
names: Miscellaneous
messages: Present with 623 molecules/cell in log phase SD medium.

559292:YHR041C
gene id: 559292:YHR041C
uniprot id: P34162
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. MED1 interacts directly with MED4 and MED7. SRB2/MED20 interacts directly with SRB4/MED17 and SRB5/MED18.
messages: Nucleus
messages: Present with 1720 molecules/cell in log phase SD medium.

559292:YKL020C
gene id: 559292:YKL020C
uniprot id: P35210
names: Function
names: Miscellaneous
messages: Dosage-dependent suppressor of Ty-induced promoter mutations. May exert its suppression effect through protein-protein interactions since does not present any of the motifs generally found in transcriptional activators or DNA binding proteins.
messages: Present with 432 molecules/cell in log phase SD medium.

559292:YOR377W
gene id: 559292:YOR377W
uniprot id: P40353
names: Activity Regulation
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATF1 alcohol acetyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Expression is repressed both by aeration and by unsaturated fatty acids (PubMed:9055409, PubMed:9675816). Also repressed by heat and ethanol stress (PubMed:14654433). Rapid induction by glucose depends on the cAMP/PKA signaling pathway (PubMed:14654433). Long-term expression requires both carbon and nitrogen sources (PubMed:14654433). The activation of transcription is dependent on RAP1, and the ROX1-TUP1p-SSN6 hypoxic repressor complex is responsible for repression by oxygen (PubMed:10487921). The putative ROX1-binding sequence in the ATF1 promoter is 5'-CCTATTGTTTT-3' and the RAP1-binding sequence is 5'-AACCCAACAAA-3' (PubMed:10487921).
messages: Found to be inhibited by cadmium, copper, zinc and mercurium divalent cations and sulfhydryl reagents (PubMed:7764365). Inhibited by the addition of unsaturated fatty acids to the culture (PubMed:7764365).
messages: Lipid droplet
messages: Major alcohol O-acetyltransferase that uses acetyl-CoA to synthesize acetate esters from various alcohols, producing ethyl acetate, isoamyl acetate, isobutyl acetate, butyl acetate, hexyl acetate, heptyl acetate and octyl acetate (PubMed:7764365, PubMed:9758847, PubMed:10653746, PubMed:12937998, PubMed:16845703, PubMed:18597084, PubMed:17891501, PubMed:25306884, PubMed:28160314). The alcohol acyltransferase activity is promiscuous with regard to alcohol but relatively specific for acetyl-CoA since ATF1 does not use any other acyl-CoAs (C3, C4, C5, C6, C8, C10, C12) (PubMed:28160314). Acts also as an efficient thioesterase in vitro with specificity towards medium-chain-length acyl-CoAs (PubMed:28160314). In natural environments, the production of aromatic volatile metabolites promotes dispersal through insect vectors (PubMed:25310977).
messages: Present with 1990 molecules/cell in log phase SD medium.
messages: Reduces levels of isoamyl acetate production during fermentation to about 16% of those produced by the wild-type strain and causes a 40% reduction of ethyl acetate formation (PubMed:12957907).
messages: Segments of the N- and C-terminal domains (residues 24-41 and 508-525, respectively) are predicted to be amphipathic helices and are essential for endoplasmic reticulum and lipid dropplet association (PubMed:25093817).
messages: Understanding the biochemistry of the volatile esters is of considerable importance in industrial agriculture, winemaking and brewing. ATF1 could profoundly affect the flavor profiles of wines and distillates deficient in aroma, thereby paving the way for the production of products maintaining a fruitier character for longer periods after bottling (PubMed:10653746, PubMed:16845703, PubMed:18597084, PubMed:25306884, PubMed:28176138). The most important acetate esters from the perspective of fermented foods and beverages are probably ethyl acetate (fruity, solvent aroma), isobutyl acetate (sweet, fruit), isoamyl acetate (banana) and 2-phenylethyl acetate (rose). In addition, the enzymes responsible for ester synthesis are targets for the metabolic engineering of cellular factories intended to produce insect pheromones for use in pest control, but also for the production of fragrances, industrial solvents, fine chemicals, pharmaceuticals and renewable biofuels (PubMed:25281839, PubMed:24609358, PubMed:26205521, PubMed:26801935).

559292:YKR053C
gene id: 559292:YKR053C
uniprot id: P23501
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type 2 lipid phosphate phosphatase family.
messages: Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases (PubMed:10477278, PubMed:10563329, PubMed:10856228, PubMed:9353337, PubMed:9419344). Involved in endocytosis and calcium-mediated signaling (PubMed:10856228).
messages: Endoplasmic reticulum membrane

559292:YIL023C
gene id: 559292:YIL023C
uniprot id: P40544
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: Endoplasmic reticulum membrane
messages: Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc conditions, it removes zinc from the secretory pathway and acts as zinc importer that helps to alleviate ER stress.

559292:YBL036C
gene id: 559292:YBL036C
uniprot id: P38197
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 4890 molecules/cell in log phase SD medium.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

559292:YNL026W
gene id: 559292:YNL026W
uniprot id: P53969
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAM50/omp85 family.
messages: Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which at least consists of SAM35, SAM37 and SAM50 (PubMed:14570913, PubMed:14685243, PubMed:15590639). Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex) (By similarity).
messages: Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.
messages: Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure.
messages: Mitochondrion outer membrane

559292:YLR352W
gene id: 559292:YLR352W
uniprot id: Q06479
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts with SKP1 and CDC53. Component of the probable SCF(YBR352W) complex containing CDC53, SKP1, RBX1 and YBR352W.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).

559292:YJR121W
gene id: 559292:YJR121W
uniprot id: P00830
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 164000 molecules/cell in log phase SD medium.

559292:YFL050C
gene id: 559292:YFL050C
uniprot id: P43553
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell membrane
messages: Plasma membrane magnesium transporter.
messages: Present with 2130 molecules/cell in log phase SD medium.

559292:YBR060C
gene id: 559292:YBR060C
uniprot id: P32833
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with MCM10 and TAH11.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
messages: Nucleus
messages: Present with 1700 molecules/cell in log phase SD medium.

559292:YML038C
gene id: 559292:YML038C
uniprot id: Q03697
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane

559292:YJR042W
gene id: 559292:YJR042W
uniprot id: P46673
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP85 is part of the heptameric 0.5 MDa autoassembling NUP84 NPC subcomplex (NUP84, NUP85, NUP120, NUP133, NUP145C, SEC13 and SEH1). NUP85 also interacts directly with the GLFG repeats of NUP116 and directly or indirectly with the mRNA transport factor MTR2.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.
messages: Nucleus membrane
messages: Present with 7920 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YKL133C
gene id: 559292:YKL133C
uniprot id: P36066
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR3 family.
messages: Membrane

559292:YCR003W
gene id: 559292:YCR003W
uniprot id: P25348
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL32 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. bL32m has a zinc binding site.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 1700 molecules/cell in log phase SD medium.

559292:YNL097C
gene id: 559292:YNL097C
uniprot id: P50947
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.
messages: Nucleus
messages: Present with 3250 molecules/cell in log phase SD medium.
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

559292:YIL068C
gene id: 559292:YIL068C
uniprot id: P32844
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC6 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Cytoplasm
messages: Present with 1080 molecules/cell in log phase SD medium.
messages: The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

559292:YCR015C
gene id: 559292:YCR015C
uniprot id: P25616
names: Function
names: Similarity
messages: Belongs to the CTO1 family.
messages: Protein required for cold tolerance (PubMed:25725023). Plays a role in the regulation of phosphate uptake (PubMed:25725023).

559292:YOL130W
gene id: 559292:YOL130W
uniprot id: Q08269
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell membrane
messages: Plasma membrane magnesium transporter.

559292:YLR411W
gene id: 559292:YLR411W
uniprot id: Q06686
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: By copper deprivation and repressed by copper excess.
messages: Cytoplasmic vesicle membrane
messages: Required for high affinity copper (probably reduced Cu I) transport into the cell.

559292:YLL002W
gene id: 559292:YLL002W
uniprot id: Q07794
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes acetylation of histone H3 'Lys-56'; simultaneous disruption of GCN5 also abolishes acetylation of histone H3 'Lys-9' and 'Lys-27' (PubMed:21256037). Decreases acetylation of histone H3 'Lys-9' and 'Lys-23' (PubMed:19172748). Decreases HTA1 RNA level; simultaneous disruption of HIR1 or RTT106 alleviates the effect (PubMed:19683497). Increases sensitivity to methyl methane sulfonate, hydroxyurea, and camptothecin (genotoxic stress) (PubMed:18568037, PubMed:18719104).
messages: Belongs to the RTT109 family.
messages: Expression peaks in cell cycle G1.
messages: Forms a complex composed of two RTT109 subunits and one VPS75 homodimer; each RTT109 subunit interacts predominantly with VPS75 instead of interacting with the other RTT109 subunit (PubMed:21256037, PubMed:20560668, PubMed:17320445, PubMed:31387991, PubMed:18719104). Interacts with VPS75; the interaction is direct (PubMed:31387991, PubMed:20560668, PubMed:17369253, PubMed:17690098, PubMed:17320445, PubMed:17272723, PubMed:18723682, PubMed:18719104, PubMed:21256037). Interacts (via C-terminus) with ASF1; the interaction is direct (PubMed:29300933, PubMed:31387991, PubMed:17690098, PubMed:17320445). Interacts with histone H3/H4 heterodimers via histone H3 (PubMed:21454705, PubMed:19172748).
messages: Histone chaperone-dependent acetylase that modifies 'Lys-9', 'Lys-14', 'Lys-23', 'Lys-27', and 'Lys-56' on histone H3 (H3K9Ac, H3K14Ac and H3K23Ac, H3K27Ac, and H3K56Ac) to promote nucleosome assembly, genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:31194870, PubMed:17046836, PubMed:17369253, PubMed:17320445, PubMed:17272723, PubMed:18723682, PubMed:20560668, PubMed:21256037, PubMed:29300933, PubMed:19172748, PubMed:19683497). Its residue selectivity is influenced by the acetylation status of histone H3, and also the presence of histone chaperone ASF1 that shifts selectivity to 'Lys-56' when H3K14Ac is already present (PubMed:31194870). H3K56 acetylation weakens the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly (PubMed:18577595). Autoacetylates (PubMed:18568037, PubMed:18707894, PubMed:18719104). Independently of acetyltransferase activity, stimulates histone deposition by VPS75 (PubMed:19172748). Involved in regulation of Ty1 transposition (PubMed:11779788).
messages: Nucleus
messages: Present with 1140 molecules/cell in log phase SD medium.

559292:YBR219C
gene id: 559292:YBR219C
uniprot id: P38317
names: Subcellular Location Annotation
messages: Membrane

559292:YIL148W
gene id: 559292:YIL148W
uniprot id: P0CH08
uniprot id: P0CH09
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2 (PubMed:23169626).
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: The 60S ribosomal protein L40 is present with 40000 molecules/cell in log phase SD medium.
messages: Ubiquitin is encoded by several different genes. UBI1 and UBI2 genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40. UBI3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. UBI4 is a polyprotein containing 5 exact head to tail repeats of ubiquitin.

559292:YPR037C
gene id: 559292:YPR037C
uniprot id: Q12284
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1.
messages: Homodimer. Interacts with the substrate protein PDI1, forming transient intermolecular disulfide bridges.
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YEL004W
gene id: 559292:YEL004W
uniprot id: P40004
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) and is required for cell wall chitin synthesis.

559292:YNL216W
gene id: 559292:YNL216W
uniprot id: P11938
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP1 family.
messages: Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.
messages: Nucleus
messages: Present with 4390 molecules/cell in log phase SD medium.
messages: RIF1, SIR3 and SIR4 associate with RAP1 C-terminus in vivo. Interacts with a GCR1 homodimer.
messages: telomere

559292:YBR173C
gene id: 559292:YBR173C
uniprot id: P38293
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the POMP/UMP1 family.
messages: Present with 2740 molecules/cell in log phase SD medium.
messages: Seems to be degraded by the proteasome upon its formation.
messages: Short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. Required for the correct assembly and enzymatic activation of the proteasome. Also prevents premature processing of the PRE2 propeptide.

559292:YJL008C
gene id: 559292:YJL008C
uniprot id: P47079
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation (By similarity).

559292:YKL048C
gene id: 559292:YKL048C
uniprot id: P32801
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Important role in G1 events required for bud emergence and septin organization. Coordinates cell growth and cell division at G2/M, essential for efficient cytokinesis and for regulation of SWE1.
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YJR022W
gene id: 559292:YJR022W
uniprot id: P47093
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the heptameric LSM2-LSM8 complex that forms a seven-membered ring structure with a doughnut shape; an RNA strand can pass through the hole in the center of the ring structure. The LSm subunits are arranged in the order LSM8, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. LSM2-LSM8 associates with PAT1 and XRN1. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, spliceosomal U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. LSM2 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1440 molecules/cell in log phase SD medium.

559292:YOL058W
gene id: 559292:YOL058W
uniprot id: P22768
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Catalyzes the eighth step in arginine biosynthesis. Also has a catabolic function as the first enzyme of citrulline utilization as nitrogen source via arginine and the reactions involved in the arginase pathway.
messages: Cytoplasm
messages: Homotetramer.
messages: Present with 1870 molecules/cell in log phase SD medium.

559292:YAR002C-A
gene id: 559292:YAR002C-A
uniprot id: Q05359
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with EMP24, ERV25 and ERP2.
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Involved in vesicular protein trafficking.
messages: Present with 20700 molecules/cell in log phase SD medium.

559292:YLR385C
gene id: 559292:YLR385C
uniprot id: Q06707
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC7 family.
messages: Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Nucleus
messages: Present with 4240 molecules/cell in log phase SD medium.

559292:YKL211C
gene id: 559292:YKL211C
uniprot id: P00937
names: Induction
names: Miscellaneous
names: Subunit
messages: By tryptophan starvation.
messages: Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
messages: Present with 13400 molecules/cell in log phase SD medium.
messages: Tetramer of two components I and two components II.
messages: Yeast component II C-terminal half also has indole-3-glycerol phosphate synthase activity.

559292:YGL077C
gene id: 559292:YGL077C
uniprot id: P19807
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid/choline transporter (ACT) (TC 2.A.3.4) family.
messages: Inhibition of activity by intracellular choline.
messages: Membrane
messages: Sole choline transporter in yeast.

559292:YIR008C
gene id: 559292:YIR008C
uniprot id: P10363
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A POL1 and B POL12, and the DNA primase large PRI2 and small PRI1 subunits.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48.
messages: Present with 197 molecules/cell in log phase SD medium.
messages: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).

559292:YDL140C
gene id: 559292:YDL140C
uniprot id: P04050
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits (PubMed:11805306, PubMed:12914699, PubMed:16341226). Interacts with DEF1; the interaction is direct and serves to bridge RPB1 to the Elongin complex in a DNA-damaged dependent manner (PubMed:23993092). Interacts with the Elongin subunit ELA1 (PubMed:23993092). Interacts with the Elongin subunit ELC1 (PubMed:23993092). Interacts with ASK10 (PubMed:14555478). Interacts with ESS1 (PubMed:10531363). Interacts with RTT103 (PubMed:15565157). Interacts with SHE2 (PubMed:20713510).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the act…
messages: Following transcription stress, the elongating form of RNA polymerase II (RNA pol IIo) is polyubiquitinated via 'Lys-63'-linkages on Lys-1246 by the RSP5-UBA1-UBC5 complex at DNA damage sites without leading to degradation: ubiquitination promotes RNA pol IIo backtracking to allow access by the transcription-coupled nucleotide excision repair (TC-NER) machinery (PubMed:32142654, PubMed:15166235, PubMed:15960978, PubMed:19920177). Subsequent DEF1-dependent polyubiquitination by the elongin complex via 'Lys-48'-linkages may lead to proteasome-mediated degradation; presumably at stalled RNA pol II where TC-NER has failed, to halt global transcription and enable 'last resort' DNA repair pathways (PubMed:15166235, PubMed:32142654, PubMed:11859374, PubMed:19920177).
messages: Mutagenesis experiments demonstrate that the minimum viable CTD contains eight consensus Y-S-P-T-S-P-[A-S-N-G] heptapeptide repeats. Identical and simultaneous substitutions in a number of consecutive repeats are lethal: 'Ser-2' -> 'Ala-2' (14 repeats), 'Ser-5' -> 'Ala-5' (15 repeats), '2-Ser-Pro-Thr-Ser-5'-> '2-Ala-Pro-Thr-Ala-5' (10 repeats), 'Ser-2'-> 'Glu-2' (15 repeats), 'Ser-5' -> 'Glu-5' (12 repeats), '2-Ser-Pro-3' -> '2-Pro-Ser-3' (15 repeats) and 'Tyr-1' -> 'Phe-1' (12 repeats).
messages: Nucleus
messages: The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
messages: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.
messages: The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat. The phosphorylated form of Pol II appears to carry, on average, one phosphate per repeat. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatases, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed. Phosphorylation at 'Ser-5' occurs in promoter-proximal regions in early elongation. Phosphorylation at 'Ser-2' predominates in regions more distal to the promoter and triggers binding of the 3' RNA processing machinery. CTD kinases include KIN28 (as part of the TFKII complex, a subcomplex of the TFIIH holo complex), SSN3/SRB10 (as part of the SRB8-11 complex, a module of the Mediator complex), CTK1 (as part of CTD kinase), and probably BUR1 (as part of the BUR1-BUR2 kinase complex). Phosphatases include FCP1 and SSU72.

559292:YLR224W
gene id: 559292:YLR224W
uniprot id: Q05947
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subunit
messages: Component of the SCF(UCC1) E3 ubiquitin-protein ligase complex composed of CDC53, SKP1, RBX1 and UCC1 (PubMed:11283612, PubMed:14747994). Interacts with CIT2 (PubMed:25982115).
messages: Expression is down-regulated by the presence of C2-compounds such as acetate.
messages: Leads to poor ubiquitination of CIT2 and accumulation of citrate in the cells.
messages: Monoubiquitinated by UBC4.
messages: Substrate recognition component of the SKP1-CUL1-F-box protein E3 ubiquitin-protein ligase complex SCF(UCC1) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10582239, PubMed:25982115). The SCF(UCC1) complex acts as a metabolic switch for the glyoxylate cycle and regulates the level of CIT2 protein to maintain citrate homeostasis (PubMed:25982115).

559292:YOL026C
gene id: 559292:YOL026C
uniprot id: Q08176
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIM1 family.
messages: Component of the MIM complex containing at least MIM1 and MIM2 (PubMed:15608614, PubMed:18187149, PubMed:21825073, PubMed:22467864). Interacts with MIM2; interaction is direct (PubMed:22467864). Interacts with TOM70 (PubMed:21825073).
messages: Component of the MIM complex required for mitochondrial outer membrane protein import (PubMed:22467864). The MIM complex cooperates with the receptor TOM70 in binding of precursor proteins and promotes their insertion and assembly into the outer membrane (PubMed:21825073). Involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including UGO1 (PubMed:21825073, PubMed:21825074). Required for the assembly of the TOM (translocase of outer membrane) receptor complex, which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:15242642, PubMed:15326197, PubMed:15608614). Required specifically for assembly of TOM40, TOM20, and TOM70, but not TOM22 (PubMed:17974559, PubMed:18187149).
messages: Leads to reduced levels of TOM complex but retains the respiratory chain.
messages: Mitochondrion outer membrane

559292:YKL219W
gene id: 559292:YKL219W
uniprot id: P36034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Membrane

559292:YBL004W
gene id: 559292:YBL004W
uniprot id: P35194
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP20 family.
messages: Cytoplasm
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

559292:YPL108W
gene id: 559292:YPL108W
uniprot id: Q02872
names: Subcellular Location Annotation
messages: Cytoplasm

559292:YDL106C
gene id: 559292:YDL106C
uniprot id: P07269
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 6420 molecules/cell in log phase SD medium.
messages: Regulator in phosphate metabolism and acts as a derepressor of another central regulator PHO5. Binds to the upstream activator sequence (UAS) of PHO5. It also binds to the TRP4, HIS4, and CYC1 promoters.

559292:YIL134W
gene id: 559292:YIL134W
uniprot id: P40464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Transport of FAD from the cytosol to the mitochondrial matrix.

559292:YJR101W
gene id: 559292:YJR101W
uniprot id: P47141
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS42 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. mS42 forms a dimer with mS43, building a large protuberance adjacent to the mRNA channel exit in the mt-SSU body.
messages: Mitochondrion
messages: Present with 2060 molecules/cell in log phase SD medium.

559292:YCL063W
gene id: 559292:YCL063W
uniprot id: P25591
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VAC17 family.
messages: Interacts with MYO2 and VAC8. Interacts with ATG18.
messages: Vacuole membrane
messages: Vacuole-specific MYO2 receptor required for vacuole inheritance. Binds simultaneously to MYO2 and to VAC8, a vacuolar membrane protein, forming a transport complex which moves the attached vacuole membrane along actin cables into the bud. Once the vacuole arrives in the bud, VAC17 is degraded, depositing the vacuole in its correct location.

559292:YCR082W
gene id: 559292:YCR082W
uniprot id: P25649
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 981 molecules/cell in log phase SD medium.

559292:YBR037C
gene id: 559292:YBR037C
uniprot id: P23833
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane
messages: Present with 2550 molecules/cell in log phase SD medium.
messages: Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.

559292:YDR151C
gene id: 559292:YDR151C
uniprot id: P47976
names: Function
names: Induction
messages: Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Negatively regulates primarily iron-dependent mitochondrial processes including respiration and amino acid biosynthesis.
messages: By transcription factors AFT1 and AFT2 in response to iron deficiency.

559292:YMR090W
gene id: 559292:YMR090W
uniprot id: Q04304
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0659 family.
messages: Cytoplasm
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YGL073W
gene id: 559292:YGL073W
uniprot id: P10961
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HSF family.
messages: DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription.
messages: Exhibits temperature-dependent phosphorylation that activates the transcriptional capacity.
messages: Homotrimer (PubMed:8175654). Homotrimerization increases the affinity of HSF1 to DNA (PubMed:8175654).
messages: Inviable vegetative cell population.
messages: Nucleus

559292:YMR015C
gene id: 559292:YMR015C
uniprot id: P54781
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome P450 family.
messages: C-22 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:8635732, PubMed:8543054). ERG5 converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain (PubMed:8635732, PubMed:8543054). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group,…
messages: Endoplasmic reticulum membrane
messages: Interacts with ERG28.
messages: Present with 24700 molecules/cell in log phase SD medium.

559292:YNR047W
gene id: 559292:YNR047W
uniprot id: P53739
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Down-regulated by YKP1 phosphorylation. This effect is counteracted in the presence of mannosyl-inositolphosphorylceramide (MIPC).
messages: Flippase activator that phosphorylates DNF1 and DNF2 and which is involved in the generation of phospholipid asymmetry in membranes by the inward translocation of phospholipids and in the retrieval pathway from early endosomes to the trans-Golgi network (TGN). Phosphorylates also the N-terminal half of YPK1. Involved in pheromone-response.
messages: Present with 752 molecules/cell in log phase SD medium.
messages: The N-terminal non-catalytic domain is phosphorylated by YPK1.

559292:YHR043C
gene id: 559292:YHR043C
uniprot id: P38773
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.
messages: Phosphatase that is active on 2-deoxy-D-glucose 6-phosphate (2-DOG-6P), but not very active on fructose-1-P.
messages: Present with 2400 molecules/cell in log phase SD medium.

559292:YBR007C
gene id: 559292:YBR007C
uniprot id: P38213
names: Disruption Phenotype
names: Miscellaneous
messages: Present with 377 molecules/cell in log phase SD medium.
messages: Rescues temperature-sensitivity of MPT5 deletion. Partially suppresses the hydroxyurea (HU) sensitivity of MPT5 deletion.

559292:YBR016W
gene id: 559292:YBR016W
uniprot id: P38216
names: Miscellaneous
messages: Present with 1760 molecules/cell in log phase SD medium.

559292:YLR129W
gene id: 559292:YLR129W
uniprot id: Q12220
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR3/UTP12 family.
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: Present with 9620 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YOL071W
gene id: 559292:YOL071W
uniprot id: Q08230
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDH1 within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDH1 of the SDH catalytic dimer. It is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDH1 in a conformation that is susceptible to autocatalytic FAD attachment (PubMed:19628817). Does not bind FAD or FADH(2) in vitro (PubMed:23062074). Involved in sporulation (PubMed:12432101). Required for the full activation of the early meiotic inducer IME1 (PubMed:12586695).
messages: Present with 1080 molecules/cell in log phase SD medium.
messages: Respiratory deficient phenotype: viable on glucose medium, but is inviable on non-fermentable carbon sources such as glycerol. Cells lack SDH activity due to a complete loss of FAD cofactor attachment of SDH1.

559292:YML001W
gene id: 559292:YML001W
uniprot id: P32939
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endocytosed alpha-factor accumulates in late endosomes.
messages: Interacts with IVY1 (PubMed:12553664). Interacts with YIF1, YIP4 and YIP5 (PubMed:11943201). Interacts with the HOPS complex (PubMed:10944212, PubMed:19386605). Interacts with the class C-Vps complex (PubMed:11062257). Interacts with VPS35 (PubMed:22593205). Interacts with VPS39 (PubMed:25026035). Interacts with the GDP dissociation inhibitor GDI1 (PubMed:11118206, PubMed:11785952).
messages: Late endosome
messages: Present with 5530 molecules/cell in log phase SD medium.
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). YPT7 is activated by GEFs MON1-CCZ1 complex (MC1) and VAM6/VPS39, and inactivated by GAPs GYP7 and GYP1.
messages: Vacuole membrane
messages: Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport. They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI). In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion (Probable). YPT7 is involved in regulation of vesicular protein transport in exo- and endocytosis (PubMed:8308065). Involved in homotypic vacuole fusion, the last step in the vacuole inheritance process, by interacting in its GTP-bound state on the donor membrane with the large multiprotein tethering complex termed HOPS on the acceptor membrane (PubMed:7489715, PubMed:11118206, PubMed:10725336, PubMed:10944212, PubMed:11210571, PubMed:19386605). Involved in the regulation of transport steps from late endosomes to the vacuole, mediated by interaction in its GTP-bound state on the donor membrane with the large multiprotein tethering complex termed class C-Vps complex on the acceptor membrane (PubMed:8308065, PubMed:11062257, PubMed:21062894). Involved in retromer assembly and cargo export, recognizing the cargo selection complex (CSC). GTP-bound YPT7 recruits CSC to vacuolar membranes via retromer subunit VPS35 (PubMed:22593205). Interacts with the HOPS complex subunit VPS39 independent of the HOPS complex at mitochondria-vacuole contact sites (vCLAMPs), providing a physical and metabolic interconnection between the endocytic pathway and mitochondria (PubMed:25026035).

559292:YMR236W
gene id: 559292:YMR236W
uniprot id: Q05027
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF9 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complex SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3, and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
messages: In TFIID, TAF9 heterodimerizes with TAF6, forming ultimately an octamer consisting of a TAF6/TAF9 heterotetramer core flanked by TAF4/TAF12 dimers on either side, similar to the histone H2A/H2B/H3/H4 octamer. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. Component of the 1.8 MDa SAGA complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9.
messages: Nucleus
messages: Present with 7000 molecules/cell in log phase SD medium.

559292:YBL043W
gene id: 559292:YBL043W
uniprot id: P38195
names: Function
messages: May be involved in cell wall organization and biogenesis.

559292:YDR309C
gene id: 559292:YDR309C
uniprot id: Q06648
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BORG/CEP family.
messages: Bud neck
messages: Bud tip
messages: Interacts with GTP-bound CDC42.
messages: Present with 1130 molecules/cell in log phase SD medium.
messages: Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.
messages: cell cortex
messages: cytoskeleton

559292:YDR510W
gene id: 559292:YDR510W
uniprot id: Q12306
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Activated by a E1 ligase composed of AOS1 and UBA2.
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Not known; suppressor of MIF2 mutations.
messages: Present with 2940 molecules/cell in log phase SD medium.

559292:YBR301W
gene id: 559292:YBR301W
uniprot id: P38155
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Component of the cell wall.
messages: Induced during anaerobic growth and completely repressed during aerobic growth.
messages: O-glycosylated.
messages: cell wall

559292:YLR410W-A
gene id: 559292:YLR410W-A
uniprot id: P0C2J4
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YDR438W
gene id: 559292:YDR438W
uniprot id: Q04083
names: Function
names: Induction
names: Subcellular Location Annotation
messages: May be involved in thiaminediphosphate transport across the mitochondrial membrane.
messages: Mitochondrion membrane
messages: Repressed by thiamine.

559292:YDR308C
gene id: 559292:YDR308C
uniprot id: P47822
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. SRB7/MED21 interacts directly with MED4, MED6, MED7 and NUT2/MED10.
messages: Nucleus
messages: Present with 1391 molecules/cell in log phase SD medium.

559292:YHR054C
gene id: 559292:YHR054C
uniprot id: P38780
names: Similarity
messages: To yeast YHR056c.

559292:YNL146W
gene id: 559292:YNL146W
uniprot id: P53906
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

559292:YNL292W
gene id: 559292:YNL292W
uniprot id: P48567
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase TruB family.
messages: Mitochondrion
messages: Nucleus
messages: Present with 3990 molecules/cell in log phase SD medium.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (PubMed:9358157). Also catalyzes pseudouridylation of mRNAs with the consensus sequence 5'-GGUUCRA-3' (PubMed:25219674).

559292:YDL128W
gene id: 559292:YDL128W
uniprot id: Q99385
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Present with 7770 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YPL223C
gene id: 559292:YPL223C
uniprot id: Q08969
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: 'De respuesta a estres' means stress response in Spanish.
messages: By osmotic, ionic and heat stress, and by water-deficiency.
messages: Cytoplasm

559292:YMR022W
gene id: 559292:YMR022W
uniprot id: Q02159
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated at Cys-89; undergoes 'Lys-48'-linked polyubiquitination, which leads to proteasome-dependent protein degradation. Degradation is autoregulated when its levels exceed that of its binding partner CUE1.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: By cadmium.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Involved in resistance to cadmium poisoning.
messages: Endoplasmic reticulum membrane
messages: Forms a heterodimer with CUE1. Interacts with SSM4/DOA10 and HDR1. Interacts with UFD4.
messages: Present with 2100 molecules/cell in log phase SD medium.

559292:YJL129C
gene id: 559292:YJL129C
uniprot id: P12685
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane
messages: This protein is required for high-affinity potassium transport.

559292:YDR490C
gene id: 559292:YDR490C
uniprot id: Q03407
names: Domain
names: Function
names: Similarity
messages: Activates YPK1 by phosphorylating of a threonine residue.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
messages: The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.

559292:YDR289C
gene id: 559292:YDR289C
uniprot id: Q05543
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with PCF11, RAI1, RAT1, RPO21 and RBP2.
messages: Involved in transcription termination by RNA polymerase II and in regulation of Ty1 transposition.
messages: Nucleus
messages: Present with 3930 molecules/cell in log phase SD medium.

559292:YDR119W
gene id: 559292:YDR119W
uniprot id: Q04602
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Transporter required for vacuolar uptake of basic amino acids.
messages: Vacuole membrane

559292:YAL009W
gene id: 559292:YAL009W
uniprot id: P18410
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NEM1-SPO7 complex.
messages: Endoplasmic reticulum membrane
messages: Leads to inefficient mitochondrial sequestration and degradation, as well as to defective reticulophagy and pexophagy (PubMed:29305265).
messages: Nucleus membrane
messages: Present with 861 molecules/cell in log phase SD medium.
messages: Regulatory component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates the phosphatidic acid phosphohydrolase PAH1 (PubMed:15889145). Essential for the formation of a spherical nucleus and meiotic division (PubMed:9822591). The NEM1-SPOo7 protein phosphatase is required for efficient mitophagy under prolonged respiration, as well as for reticulophagy and pexophagy (PubMed:29305265).

559292:YFR032C
gene id: 559292:YFR032C
uniprot id: P43607
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the RRT5 family.
messages: May be involved in the modulation of rDNA transcription.
messages: Present with 51100 molecules/cell in log phase SD medium.
messages: Specifically expressed during sporulation.

559292:YNL020C
gene id: 559292:YNL020C
uniprot id: P53974
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with ABP1, which is required for proper actin patch localization.
messages: Involved in regulation of actin cytoskeleton organization and endocytosis.
messages: Present with 1551 molecules/cell in log phase SD medium.
messages: actin patch

559292:YJL045W
gene id: 559292:YJL045W
uniprot id: P47052
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: In vitro, can complement a SDH1 disruption and leads to less than 15% of wild-type SDH reductase activity probably due to its lower expression level (compared to SDH1).
messages: Mitochondrion inner membrane
messages: Probable minor catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Probably forms a catalytic dimer with SDH2. Electrons flow from succinate to the FAD bound to the catalytic subunit, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.

559292:YHL044W
gene id: 559292:YHL044W
uniprot id: P38727
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DUP/COS family.
messages: Cell membrane
messages: Interacts according to large scale protein interaction studies with BZZ1, SRB4 and SUA7.
messages: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.

559292:YOR337W
gene id: 559292:YOR337W
uniprot id: P47988
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 736 molecules/cell in log phase SD medium.
messages: TY1 element enhancer binding protein. Binds to the DNA sequence 5'-TCGGTGGTATTATTCCGA-3'.
messages: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

559292:YHL014C
gene id: 559292:YHL014C
uniprot id: P38746
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP (By similarity).
messages: Mitochondrion
messages: Present with 2360 molecules/cell in log phase SD medium.

559292:YGR087C
gene id: 559292:YGR087C
uniprot id: P26263
names: Biotechnology
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cytoplasm
messages: Expression is very low in the presence of fermentable carbon sources, but is induced, in contrast to PDC5, by ethanol.
messages: Fusel oils and acyloins are important flavor and aroma compounds in yeast-fermented products contributing to the quality of beverages and food, e.g. fusel oils in whiskey, contrary to common believe, seem to alleviate hangover. In general they are desirable at low concentrations, whereas high concentrations may spoil the product. By adjusting growth conditions and substrate their production is sought to be influenced. Due to their broad substrate tolerance pyruvate decarboxylases are important biocatalysts for chemoenzymatic syntheses, both by fermentation and in vitro, e.g. in the production of ephedrine, vitamin E, or phenylethanol (rose flavor).
messages: Homotetramer.
messages: Minor of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids derived from threonine (2-oxobutanoate), norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, also alpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate), and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins. The expression level of this protein in the presence of fermentable carbon sources is so low that it cannot compensate for the other two pyruvate decarboxylases to sustain fermentation.
messages: Present with 1525 molecules/cell in log phase SD medium.

559292:YML072C
gene id: 559292:YML072C
uniprot id: Q03640
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tricalbin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with TCB2 via its C-terminal domain.
messages: May play a role in membrane trafficking.
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: The C-terminal C2 domain shows Ca(2+)-dependent phospholipid binding. It binds to phosphatidylserine, phosphatidylinositol and various phosphoinositides. The other C2 domains do not retain all 5 conserved Asp residues found in calcium-binding C2 domains.

559292:YDR017C
gene id: 559292:YDR017C
uniprot id: Q12494
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol phosphokinase (IPK) family.
messages: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance.
messages: Cytoplasm
messages: Present with 1940 molecules/cell in log phase SD medium.

559292:YGR202C
gene id: 559292:YGR202C
uniprot id: P13259
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
messages: Membrane
messages: Present with 3050 molecules/cell in log phase SD medium.

559292:YDR450W
gene id: 559292:YDR450W
uniprot id: P0CX55
uniprot id: P0CX56
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 112000 molecules/cell in log phase SD medium.
messages: Present with 48100 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS13 in yeast.

559292:YDR506C
gene id: 559292:YDR506C
uniprot id: Q04399
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the multicopper oxidase family.
messages: Binds 4 Cu cations per monomer.
messages: Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport (By similarity). Involved in meiotic prophase and synaptonemal complex (SC) assembly.
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YER130C
gene id: 559292:YER130C
uniprot id: P39959
names: Subcellular Location Annotation
messages: Nucleus

559292:YPL222W
gene id: 559292:YPL222W
uniprot id: Q08968
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Tyr residues of target mitochondrial proteins (AMPylation) (PubMed:30270044). Involved in redox homeostasis by regulating the cellular response to oxidative stress (PubMed:30270044). Regulates protein S-glutathionylation levels possibly by AMPylation of deglutathionylation enzymes such as glutaredoxins (PubMed:30270044).
messages: Forms probably one or more intrachain disulfide bridges.
messages: Induced in absence of non-fermentable carbon sources including glycerol, lactate, and acetate (at protein level) (PubMed:30270044). Expression is regulated by zinc levels (PubMed:17938904).
messages: Mitochondrion
messages: Present with 2430 molecules/cell in log phase SD medium.
messages: Reduced growth and survival in presence of oxygen reactive species.

559292:YLR200W
gene id: 559292:YLR200W
uniprot id: P52553
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Nucleus
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YBR145W
gene id: 559292:YBR145W
uniprot id: P38113
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Present with 1310 molecules/cell in log phase SD medium.

559292:YNL087W
gene id: 559292:YNL087W
uniprot id: P48231
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tricalbin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with TCB1 and TCB3 via its C-terminal domain.
messages: May play a role in membrane trafficking.
messages: Present with 2630 molecules/cell in log phase SD medium.
messages: The C2 domains show Ca(2+)-independent phospholipid binding. None of the C2 domains retains all 5 conserved Asp residues found in calcium-binding C2 domains.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

559292:YLR131C
gene id: 559292:YLR131C
uniprot id: P21192
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in regulating basal-level expression of CUP1. Activates EGT2 transcription in the absence of SWI5.
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YNR010W
gene id: 559292:YNR010W
uniprot id: P33308
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. CSE2/MED9 interacts directly with MED4.
messages: Nucleus
messages: Present with 1364 molecules/cell in log phase SD medium.

559292:YLR382C
gene id: 559292:YLR382C
uniprot id: P11325
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of leucine to tRNA(Leu) in the mitochondrion.
messages: Mitochondrion matrix
messages: Present with 2120 molecules/cell in log phase SD medium.
messages: PubMed:3034607 authors identified this protein as the gene product of the NAM2 gene, which is capable of compensating for mutations in mRNA maturase encoded by the fourth intron of the mitochondrial cytochrome b gene.

559292:YHR025W
gene id: 559292:YHR025W
uniprot id: P17423
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate in the threonine biosynthesis pathway.
messages: Homodimer.
messages: Present with 92600 molecules/cell in log phase SD medium.

559292:YPR128C
gene id: 559292:YPR128C
uniprot id: Q06497
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation.
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Induced by oleic acid, through its ORE-like (oleate responsive element) promoter element and the PIP2-OAF1 transcription factors.
messages: Peroxisome membrane
messages: Present with 2250 molecules/cell in log phase SD medium.

559292:YLR359W
gene id: 559292:YLR359W
uniprot id: Q05911
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site (By similarity).

559292:YHR079C-A
gene id: 559292:YHR079C-A
uniprot id: P89114
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWI5/SAE3 family.
messages: During meiosis.
messages: Forms a ternary complex with DMC1 and MEI5.
messages: Involved in meiotic DNA-break repair. Required for the recruitment of DCM1 to meiosis recombination hot spots.
messages: Nucleus

559292:YOR328W
gene id: 559292:YOR328W
uniprot id: P51533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

559292:YMR286W
gene id: 559292:YMR286W
uniprot id: P20084
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YGL194C
gene id: 559292:YGL194C
uniprot id: P53096
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Identified in a Set3C complex with SET3, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.
messages: Nucleus
messages: Present with 4890 molecules/cell in log phase SD medium.
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation.

559292:YDR298C
gene id: 559292:YDR298C
uniprot id: P09457
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 32400 molecules/cell in log phase SD medium.

559292:YOL109W
gene id: 559292:YOL109W
uniprot id: Q08245
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts antagonistically to MID2 in signaling cell wall stress to the PKC1-MPK1 cell integrity pathway.
messages: Cell membrane
messages: Interacts with MID2.
messages: Phosphorylation of Ser-25 is induced 2-fold in response to mating pheromone.

559292:YNL322C
gene id: 559292:YNL322C
uniprot id: P17260
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE1 family.
messages: Cell membrane
messages: Extensively modified; probably through addition of O-linked mannose residues.
messages: Involved in a late stage of cell wall 1,6-beta-glucan synthesis and assembly. Has a structural, rather than enzymic, function within cell wall 1,6-beta-glucan assembly and architecture, possibly by being involved in covalently cross-linking 1,6-beta-glucans to other cell wall components such as 1,3-beta-glucan, chitin and certain mannoproteins. Acts as the plasma membrane receptor for the yeast K1 viral toxin.
messages: Present with 623 molecules/cell in log phase SD medium.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

559292:YNL101W
gene id: 559292:YNL101W
uniprot id: P50944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
messages: Vacuole membrane

559292:YDL066W
gene id: 559292:YDL066W
uniprot id: P21954
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: By growth with glucose as a carbon source.
messages: Homodimer.
messages: Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH.
messages: Mitochondrion
messages: The enzyme is subject to end product inhibition by NADPH and 2-oxoglutarate.

559292:YJL157C
gene id: 559292:YJL157C
uniprot id: P21268
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subunit
messages: Associates with the CDC28-CLN complex.
messages: By alpha-factor in a cells.
messages: Inhibitor of the cyclin-dependent kinase CDC28. Necessary for cell cycle arrest. Involved in pheromone response. Contributes to mating efficiency. Required for oriented polarization of yeast cells in response to mating pheromones.
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Some mutants appear to be defective in mating because they are unable to locate the mating partner.
messages: There is evidence to suggest that the N-terminal part may be sufficient for cell cycle arrest and the C-terminal may be necessary for some step in mating.
messages: Thought to be phosphorylated by MAP kinase FUS3. Thought to enhance the binding of FAR1 to G1-specific cyclin-dependent kinase (CDK) complexes.

559292:YLR394W
gene id: 559292:YLR394W
uniprot id: Q06032
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the synapsis initiation complex (SIC) necessary for the synaptonemal complex assembly. Stabilizes the ZIP2 component to the chromosomes. The SIC complex loads onto chromosomes and nucleates ZIP1 polymerization, a molecular zipper that acts to bring homologous chromosomes in close apposition, which is required for meiotic crossover. May also be involved in double strand break repair.
messages: Component of the synapsis initiation complex composed of at least ZIP2, ZIP3, MSH4 and MSH5. Interacts also with ZIP1, MRE11, RAD51 and RAD53.
messages: Expressed during meiosis.
messages: Nucleus

559292:YPL262W
gene id: 559292:YPL262W
uniprot id: P08417
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:3040736, PubMed:11585823, PubMed:1587456, PubMed:20231875). In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (PubMed:1587456, PubMed:20231875). In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate (PubMed:20231875).
messages: Cells accumulate extracellular fumarate.
messages: Cytoplasm
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Nucleus
messages: Present with 6920 molecules/cell in log phase SD medium.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

559292:YMR042W
gene id: 559292:YMR042W
uniprot id: P07249
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ARG81 and ARG82.
messages: Nucleus
messages: With ARG81, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.

559292:YGR278W
gene id: 559292:YGR278W
uniprot id: P53333
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome subcomplex composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Belongs to the CWC22 family.
messages: Cytoplasm
messages: May be involved in pre-mRNA splicing.
messages: Nucleus
messages: Present with 3260 molecules/cell in log phase SD medium.

559292:YDL108W
gene id: 559292:YDL108W
uniprot id: P06242
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: CCL1 and KIN28 form the TFIIK complex, a component of the TFIIH holo complex. Component of a complex consisting of KIN28, CCL1 and TFB3. Interacts with TFB3. Also interacts with HNT1 and HOG1.
messages: Catalytic component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro. Essential for cell proliferation.
messages: Nucleus
messages: Phosphorylation of Thr-162 regulates the affinity of interaction between CCL1, KIN28 and TFB3. Thr-162 phosphorylation does not vary through the cell cycle and is necessary for full kinase activity.
messages: Present with 4400 molecules/cell in log phase SD medium.

559292:YNL202W
gene id: 559292:YNL202W
uniprot id: P32573
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: By oleate. Transcription is regulated by the transcription factors PIP2, OAF1 and ADR1. Weakly induced during sporulation in diploid cells.
messages: Homodimer.
messages: Peroxisome
messages: Sequentially activated during the process of meiosis and spore formation.

559292:YKL064W
gene id: 559292:YKL064W
uniprot id: P35724
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YER174C
gene id: 559292:YER174C
uniprot id: P32642
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutaredoxin family. Monothiol subfamily.
messages: Homodimer. Heterodimer with FRA2.
messages: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable).
messages: Present with 7800 molecules/cell in log phase SD medium.

559292:YBR009C
gene id: 559292:YBR009C
uniprot id: P02309
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Nucleus
messages: Present with 524000 molecules/cell in log phase SD medium.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Histone H4 is a component of the UAF (upstream activation factor) complex which consists of UAF30, RRN5, RRN9, RRN10, and histones H3 and H4.

559292:YKL074C
gene id: 559292:YKL074C
uniprot id: P36084
names: Function
names: Miscellaneous
names: Subunit
messages: MSL5, MUD2 and PRP40 interact to form the commitment complex 2 (CC2), a precursor of mature spliceosomes.
messages: Present with 4170 molecules/cell in log phase SD medium.
messages: Splicing factor that contacts pre-mRNA directly and is a component of the pre-mRNA-U1 snRNP complex (commitment complex 2) that forms during early spliceosome assembly in yeast extracts.

559292:YEL072W
gene id: 559292:YEL072W
uniprot id: P39975
names: Function
messages: Required for sporulation. Required for meiotic nuclear division.

559292:YNL301C
gene id: 559292:YNL301C
uniprot id: P0CX49
uniprot id: P0CX50
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). eL18 interacts with NAP1 (PubMed:18086883).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 63700 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL18 in yeast.

559292:YAL033W
gene id: 559292:YAL033W
uniprot id: P28005
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2230 molecules/cell in log phase SD medium.

559292:YNL075W
gene id: 559292:YNL075W
uniprot id: P53941
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.
messages: nucleolus

559292:YOR040W
gene id: 559292:YOR040W
uniprot id: Q12320
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Mitochondrion matrix
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

559292:YML015C
gene id: 559292:YML015C
uniprot id: Q04226
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF11 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus
messages: TAF11 heterodimerizes with TAF13, but they do not seem to form a heterotetramer like TAF6/TAF9. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors (one copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14), ranging in size from 17 to 150 kDa.

559292:YGL184C
gene id: 559292:YGL184C
uniprot id: P53101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the trans-sulfuration enzymes family.
messages: Cytoplasm
messages: Nucleus

559292:YDR061W
gene id: 559292:YDR061W
uniprot id: Q12298
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Induced by transcription factor YRM1.
messages: Mitochondrion
messages: Present with 1580 molecules/cell in log phase SD medium.

559292:YLR055C
gene id: 559292:YLR055C
uniprot id: P38915
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SPT8 family.
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA.
messages: Nucleus
messages: Present with 8430 molecules/cell in log phase SD medium.
messages: Required, directly or indirectly, for TATA-binding protein function at particular promoters. May promote a functional interaction between SPT3 and TATA-binding protein. Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs).

559292:YMR182C
gene id: 559292:YMR182C
uniprot id: Q00453
names: Domain
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 1230 molecules/cell in log phase SD medium.
messages: The Pro-rich region of rgm1 attached to a heterologous DNA binding domain is able to repress the expression of the target gene.
messages: Under the control of the inducible GAL10 promoter.

559292:YLR266C
gene id: 559292:YLR266C
uniprot id: Q06149
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Up-regulates the transcription of the genes for ATP-binding cassette (ABC) transporters YOR1 and PDR15, for major facilitator superfamily transporter AZR1, for pleiotropic drug resistance SNG1, for alpha-glucosidase YJL216C and for YLL056C.

559292:YPL255W
gene id: 559292:YPL255W
uniprot id: Q12365
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBP1 family.
messages: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression.
messages: Homodimer. Interacts with KAR1, MPS2 and SPC29.
messages: Present with 922 molecules/cell in log phase SD medium.
messages: The C-ter coiled-coil domain is sufficient for localization and homodimerization.
messages: spindle pole body

559292:YPL260W
gene id: 559292:YPL260W
uniprot id: Q08977
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CUB1 family.
messages: Cytoplasm
messages: Expression is induced in response to DNA replication stress.
messages: Involved in bleomycin tolerance with links to DNA repair and/or proteasome function.
messages: Leads to sensitivity to bleomycin (Ref.7). Bleomycin sensnsitivity is even increased when CUB1 deletion is combined with proteasome mutants including PRE9 or UMP1 disruptions (Ref.7). Suppresses the copper tolerance induced by the proteasome subunit PRE9 disuption (Ref.7). Leads to synthetic sickness with deletion of RAD6 on media containing bleomycin, but not hydroxyurea (HU) (Ref.7).
messages: Monomer.
messages: Nucleus
messages: Phosphorylated by PKA in vitro.

559292:YNL122C
gene id: 559292:YNL122C
uniprot id: P53921
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

559292:YDR531W
gene id: 559292:YDR531W
uniprot id: Q04430
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type II pantothenate kinase family.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in the physiological regulation of the intracellular CoA concentration.
messages: Present with 6190 molecules/cell in log phase SD medium.
messages: Regulated by feedback inhibition by malonyl-CoA.

559292:YLR148W
gene id: 559292:YLR148W
uniprot id: P27801
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS18 family.
messages: Component of the HOPS complex which is composed of PEP5, VPS16, PEP3, VPS33, VPS39 and VPS41. HOPS associates with phosphoinositides and the PX domain of VAM7. Interacts with PEP5, PEP7 and VAM7.
messages: Present with 2020 molecules/cell in log phase SD medium.
messages: Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
messages: Vacuole membrane

559292:YBR257W
gene id: 559292:YBR257W
uniprot id: P38336
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Nucleus
messages: Required for 5.8S rRNA and tRNA processing; associated with RNase MRP and RNase P.

559292:YML014W
gene id: 559292:YML014W
uniprot id: P49957
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with TRM112.
messages: Nucleus
messages: Present with 2360 molecules/cell in log phase SD medium.
messages: Required for the methylation of the wobble bases at position 34 in tRNA. Appears to have a role in stress-response.

559292:YBL040C
gene id: 559292:YBL040C
uniprot id: P18414
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor strongly recognizes H-D-E-L and weakly recognizes D-D-E-L and K-D-E-L.

559292:YNL082W
gene id: 559292:YNL082W
uniprot id: P14242
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Heterodimer of MLH1 and PMS1, called MutLalpha, which is the major MMR MutL activity correcting base-base mismatches as well as IDLs. The heterodimer binds double strand DNA independently of a mismatch with positive cooperativity and has more than one DNA binding site. Forms a ternary complex with either the MSH2-MSH6 (MutSalpha) or the MSH2-MSH3 heterodimer (MutSbeta), which recognize and bind to mismatch DNA. Ternary complex formation is promoted by ATP binding.
messages: Nucleus
messages: Present with 521 molecules/cell in log phase SD medium.
messages: Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates.

559292:YOR290C
gene id: 559292:YOR290C
uniprot id: P22082
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Involved in transcriptional activation. Catalytic component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Nucleus
messages: Present with 217 molecules/cell in log phase SD medium.

559292:YBR262C
gene id: 559292:YBR262C
uniprot id: P38341
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic12 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex. Interacts with OM45 and POR1.
messages: Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.
messages: Mitochondrion inner membrane
messages: Present with 2550 molecules/cell in log phase SD medium.

559292:YDR261W-A
gene id: 559292:YDR261W-A
uniprot id: Q99303
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YPR143W
gene id: 559292:YPR143W
uniprot id: Q06511
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP15 family.
messages: Constituent of pre-60S ribosomal particles. Required for large subunit rRNA maturation, in particular processing of the 27S pre-rRNA at the A3 and B1 sites to yield 5.8S and 25S rRNA.
messages: Present with 6200 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YHR197W
gene id: 559292:YHR197W
uniprot id: P38883
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIX1/PELP1 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits (PubMed:11313466, PubMed:14759368, PubMed:15528184, PubMed:26619264). Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:26619264).
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles (PubMed:14690591, PubMed:14759368, PubMed:15260980, PubMed:15528184, PubMed:26619264). Interacts with NUG1 (PubMed:11583615). Interacts with IPI3 (PubMed:14690591).
messages: Nucleus
messages: Present with 7820 molecules/cell in log phase SD medium.
messages: Sumoylated.

559292:YIL118W
gene id: 559292:YIL118W
uniprot id: Q00245
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Plays an important role in cell growth. Required to keep the uninucleated state. May be involved in the organization of the cytoskeleton which affects microtubule functions. Most likely RHO3 and RHO4 of S.cerevisiae regulate partially overlapping but different pathways.
messages: Present with 5910 molecules/cell in log phase SD medium.

559292:YBR211C
gene id: 559292:YBR211C
uniprot id: P38313
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-U/AME1 family.
messages: Component of the heterotetrameric kinetochore subcomplex COMA, which consists of AME1, CTF19, MCM21 and OKP1 (PubMed:14633972). The COMA subcomplex is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). COMA binds the centromeric nucleosome-binding protein MIF2, and to the outer kinetochore MIND subcomplex, probably via AME1. AME1 interacts directly with OKP1 and an NKP1-NKP2 dimer (By similarity).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Nucleus
messages: Present with 1630 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YER060W
gene id: 559292:YER060W
uniprot id: P40039
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane
messages: Probable purine-cytosine permease.

559292:YER063W
gene id: 559292:YER063W
uniprot id: P40040
names: Function
names: Miscellaneous
messages: Present with 6580 molecules/cell in log phase SD medium.
messages: Unknown; suppressor of the transcriptional defect of HPR1 by overexpression.

559292:YIL113W
gene id: 559292:YIL113W
uniprot id: P40479
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.

559292:YOR244W
gene id: 559292:YOR244W
uniprot id: Q08649
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Autoacetylation at Lys-262 is required for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Catalytic component of the NuA4 histone acetyltransferase (HAT), a multiprotein complex involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (PubMed:9520405, PubMed:12379856, PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:16543223, PubMed:18245364, PubMed:9858608). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608). Acetylation of histones gives a specific tag for epigenetic transcription initiation and elongation (PubMed:16543223, PubMed:19822662). Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608). Involved in cell cycle progression (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608). Recruitment to promoters depends on H3K4me (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608). Also acetylates non-histone proteins, such as ATG3 and PAH1 (PubMed:22539722, PubMed:29765047). Regulates autophagy by acetylating ATG3, controlling interaction the interaction between ATG3 and ATG8 and ATG8 lipidation (PubMed:22539722). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzi…
messages: Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, SWC4, TRA1, VID21, YAF9 and YNG2. The complex interacts with histones H4 (HHF1 and HHF2), H3 (HHT1 and HHT2) and H2A (HTA1 and HTA2).
messages: Present with 1170 molecules/cell in log phase SD medium.
messages: The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.
messages: The catalytic mechanisms is still under debate. Cys-304 was proposed to function as a nucleophile that forms a covalent intermediate with acetyl-CoA during the reaction (PubMed:12368900), and indeed the residue can be acetylated (in vitro) (PubMed:12368900 and PubMed:17223684). Depending on the assay system, mutation of Cys-304 leads to reduced or undetectable activity, indicating that is plays an important role. Still, mutation of Cys-304 has only a minor effect on the catalytic activity of the NuA4 histone acetyltransferase (HAT) complex (PubMed:17223684), making it unlikely that this residue functions as the catalytic nucleophile.

559292:YLR310C
gene id: 559292:YLR310C
uniprot id: P04821
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 319 molecules/cell in log phase SD medium.
messages: Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.

559292:YGR038C-A
gene id: 559292:YGR038C-A
uniprot id: Q12485
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-GR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YDR034C-A
gene id: 559292:YDR034C-A
uniprot id: P0C289
names: Subcellular Location Annotation
messages: Membrane

559292:YGR179C
gene id: 559292:YGR179C
uniprot id: P53298
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-Q/OKP1 family.
messages: Component of the heterotetrameric kinetochore subcomplex COMA, which consists of AME1, CTF19, MCM21 and OKP1 (PubMed:14633972). The COMA subcomplex is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). COMA binds the centromeric nucleosome-binding protein MIF2, and to the outer kinetochore MIND subcomplex. OKP1 interacts directly with AME1, with an NKP1-NKP2 dimer, and with CTF19-MCM21 (PubMed:29046335).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Nucleus
messages: Present with 2688 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YJR118C
gene id: 559292:YJR118C
uniprot id: P47155
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ILM1 family.
messages: Endoplasmic reticulum membrane
messages: Present with 1160 molecules/cell in log phase SD medium.

559292:YNL070W
gene id: 559292:YNL070W
uniprot id: P53507
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom7 family.
messages: Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM7 is involved in assembly and stability of the TOM complex.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70).
messages: Mitochondrion outer membrane
messages: Present with 3250 molecules/cell in log phase SD medium.

559292:YPL225W
gene id: 559292:YPL225W
uniprot id: Q08971
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PBDC1 family.
messages: Cytoplasm
messages: Present with 37500 molecules/cell in log phase SD medium.

559292:YBL039C
gene id: 559292:YBL039C
uniprot id: P28274
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Activated by GTP and inhibited by CTP.
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
messages: Homodimer. Oligomerizes to a tetramer in the presence of its substrates UTP and ATP.
messages: Present with 57600 molecules/cell in log phase SD medium.

559292:YKL052C
gene id: 559292:YKL052C
uniprot id: P35734
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex ASK1 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: Present with 2836 molecules/cell in log phase SD medium.
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle

559292:YAL008W
gene id: 559292:YAL008W
uniprot id: P18411
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Membrane
messages: Present with 1920 molecules/cell in log phase SD medium.

559292:YDR069C
gene id: 559292:YDR069C
uniprot id: P32571
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Interacts with BRO1, RFU1 and VPS32. Associates with the 26S proteasome.
messages: Late endosome membrane
messages: Present with 428 molecules/cell in log phase SD medium.
messages: RFU1 is an inhibitor of deubiquitination activity.
messages: Residues 1-208 are essential for the localization to the late endosome and constitute a late endosome localization (LEL) domain.
messages: Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole. Removes also ubiquitin from soluble proteins targeted to proteasomes. Is essential to maintain a normal level of free ubiquitin. Involved in the ammonium-induced down-regulation of the GAP1 permease and the UME3 destruction in response to oxidative stress. Has a role in the RAD9 checkpoint response to TOP1 poisons. Required for promoting coordination of DNA replication and avoids DNA overreplication.

559292:YNL317W
gene id: 559292:YNL317W
uniprot id: P42841
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of at least PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Interacts with YSH1/BRR5, FIP1 and RNA14.
messages: Integral and essential component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May bridge the CPF and CFIA complexes.
messages: Nucleus
messages: Present with 7810 molecules/cell in log phase SD medium.

559292:YNL327W
gene id: 559292:YNL327W
uniprot id: P42835
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Exclusively expressed between the end of mitosis and early G1; inactivated before cells pass start.
messages: Membrane
messages: Seems to be involved in the correct timing of cell separation after cytokinesis, as separation of mutant daughter cells is delayed. Could either be an enzyme necessary for glucans-degradation of the cell wall at the neck region between mother and daughter cells or a regulatory protein controlling this metabolic step.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
messages: cell wall

559292:YFL034W
gene id: 559292:YFL034W
uniprot id: P43564
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO4 family.
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with RPP0 (PubMed:15286401). Interacts with APM2 (PubMed:26658609).
messages: Present with 1110 molecules/cell in log phase SD medium.
messages: Probable lipase that recruits the AP-1-related (AP-1R) complex to membranes via interaction with APM2 (PubMed:26658609). The AP-1R complex is an adapter protein complex that mediates of cargo protein SNC1 sorting in clathrin-coated vesicles (PubMed:26658609).
messages: clathrin-coated vesicle membrane

559292:YLR326W
gene id: 559292:YLR326W
uniprot id: Q06170
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: During S phase of the cell cycle.
messages: Membrane
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:YML073C
gene id: 559292:YML073C
uniprot id: Q02326
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL6 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 37100 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL6 in yeast.

559292:YDR066C
gene id: 559292:YDR066C
uniprot id: Q12378
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1050 molecules/cell in log phase SD medium.
messages: Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1.

559292:YHR179W
gene id: 559292:YHR179W
uniprot id: Q03558
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
messages: Cytoplasm
messages: Flavin-dependent enoate reductase that catalyzes the chemo- and stereoslective hydrogenation of electron-poor alkenes. The enzyme is reduced by NADPH, and oxygen, quinones, and alpha,beta-unsaturated aldehydes and ketones can act as electron acceptors to complete catalytic turnover. The physiological oxidant remains elusive (By similarity). Has an antioxidant activity, reducing reactive oxygen species (ROS) levels when overexpressed. Formation of OYE2-OYE3 heterodimers contribute to the induction of programmed cell death upon oxidative stress (PubMed:17897954).
messages: Homodimer or heterodimer with OYE3.
messages: Mitochondrion
messages: Nucleus
messages: Present with 15100 molecules/cell in log phase SD medium.

559292:YMR030W
gene id: 559292:YMR030W
uniprot id: Q05043
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cytoplasm
messages: During respiratory growth.
messages: Mitochondrial and nuclear transcriptional activator required for respiratory growth.
messages: Mitochondrion
messages: Nucleus

559292:YDL181W
gene id: 559292:YDL181W
uniprot id: P01097
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.
messages: Mitochondrion
messages: Present with 981 molecules/cell in log phase SD medium.

559292:YCR093W
gene id: 559292:YCR093W
uniprot id: P25655
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT1 family.
messages: Cytoplasm
messages: Forms a NOT protein complex that comprises NOT1, NOT2, NOT3, NOT4 and NOT5. Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with CCR4, POP2, NOT2, NOT4 and NOT5. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.
messages: Nucleus
messages: Present with 4300 molecules/cell in log phase SD medium.

559292:YDR155C
gene id: 559292:YDR155C
uniprot id: P14832
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Cytoplasm
messages: Interacts with a complex composed of SIN3 and RPD3. Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, HOS4/YIL112W and SET3.
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in histone deacetylase complexes, suggesting a function in chromatin. Imports fructose-1,6-bisphosphatase (FBPase) into the intermediate vacuole import and degradation (Vid) vesicles. Regulates the meiotic gene program via the Set3C histone deacetylase complex to promote efficient sporulation, and the prolyl-isomerase activity is required for this function.
messages: Present with 86000 molecules/cell in log phase SD medium.

559292:YML071C
gene id: 559292:YML071C
uniprot id: Q04632
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.
messages: Golgi apparatus membrane
messages: Present with 6440 molecules/cell in log phase SD medium.

559292:YDL092W
gene id: 559292:YDL092W
uniprot id: P38985
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14 (PubMed:7925282). At least SRP14, SRP21, SRP68 and SRP72 are proposed to get assembled together with scR1 RNA as a pre-SRP complex in the nucleolus which is exported to the cytoplasm. SRP14 binds RNA as a homodimer (PubMed:7925282).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:7925282, PubMed:10573124). The SRP complex is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences (PubMed:10573124). It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting (PubMed:10573124). SRP14 binds scR1 RNA to form the probable Alu domain of SRP responsible for elongation arrest (PubMed:10573124).
messages: Cytoplasm
messages: Nucleus
messages: Present with 8000 molecules/cell in log phase SD medium.

559292:YLL029W
gene id: 559292:YLL029W
uniprot id: Q07825
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24B family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with FRA2.
messages: Involved in the regulation of the iron regulon in responss to decreased mitochondrial iron-sulfur cluster synthesis.
messages: Present with 3237 molecules/cell in log phase SD medium.

559292:YOR172W
gene id: 559292:YOR172W
uniprot id: Q12340
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Transcription factor involved in the regulation of multidrug resistance genes. Acts in concert with YRR1.

559292:YPL046C
gene id: 559292:YPL046C
uniprot id: Q03071
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair (PubMed:19920177). Prevents degradation of interacting proteins like PCL6 by the proteasome (PubMed:11864988).
messages: Belongs to the SKP1 family.
messages: Cytoplasm
messages: During sporulation.
messages: Heterodimer with ELA1 (PubMed:10430890, PubMed:10753924, PubMed:10998253, PubMed:11545595, PubMed:23993092). Component of a CRL3 E3 ubiquitin ligase complex consisting of the cullin CUL3, the linker protein ELC1, the substrate receptor ELA1, and the RING protein HRT1 (PubMed:19920177). Interacts with CIN5 (PubMed:10760578). Interacts with PCL6 (PubMed:10760578). Interacts with SNF4 (PubMed:10760578). Interacts with the large RNA polymerase II subunit RPO21 in a manner dependent on DEF1 (PubMed:23993092). Interacts with DEF1 (PubMed:23993092). Interacts with RAD7 (PubMed:19920177). Interacts with RAD16 (PubMed:19920177).
messages: In contrast to other members of the family it does not integrate a functional E3 ubiquitin complex.
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YDR390C
gene id: 559292:YDR390C
uniprot id: P52488
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of UBA2 and AOS1. The complex binds SMT3.
messages: Multiubiquitinated in vivo.
messages: Nucleus
messages: Present with 18800 molecules/cell in log phase SD medium.
messages: The dimeric enzyme acts as a SMT3 E1 ligase. It mediates ATP-dependent activation of SMT3 and formation of a thioester with a conserved cysteine residue on AOS1.

559292:YOR187W
gene id: 559292:YOR187W
uniprot id: P02992
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: G-protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA. Required for mitochondrial protein biosynthesis and maintenance of mitochondrial DNA.
messages: Mitochondrion
messages: Present with 58527 molecules/cell in log phase SD medium.
messages: The precursor is processed in two steps involving mitochondrial intermediate peptidase (MIP) and mitochondrial processing peptidase (MPP).

559292:YDR530C
gene id: 559292:YDR530C
uniprot id: P22108
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP. Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates, but prefers A-containing substrates. Cannot catalyze the reverse reaction. Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange reaction between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.
messages: Belongs to the ATP adenylyltransferase family.
messages: Cytoplasm
messages: Inactivation of both APA1 and APA2 promotes a great increase in the cellular concentration of bis(5'-nuceleosidyl) tetraphosphate nucleotides.
messages: Monomer.
messages: Nucleus
messages: Present with 1770 molecules/cell in log phase SD medium.

559292:YIL120W
gene id: 559292:YIL120W
uniprot id: P40475
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: Cell membrane
messages: Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole.

559292:YGL019W
gene id: 559292:YGL019W
uniprot id: P43639
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Phosphorylated by alpha subunit.
messages: Present with 8120 molecules/cell in log phase SD medium.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).
messages: Tetramer composed of an alpha subunit, an alpha' subunit, one beta subunit and one beta' subunit (PubMed:12242279). Interacts with FACT subunits POB3 and SPT16 (PubMed:12242279). interacts with YTA7 (PubMed:22156209).

559292:YNL054W-B
gene id: 559292:YNL054W-B
uniprot id: Q99337
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YNL054W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YKL044W
gene id: 559292:YKL044W
uniprot id: P36092
names: Subcellular Location Annotation
messages: Membrane

559292:YBR150C
gene id: 559292:YBR150C
uniprot id: P38114
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Involved in tolerance to thiabendazole.
messages: Mitochondrion membrane
messages: Nucleus membrane
messages: Present with 573 molecules/cell in log phase SD medium.

559292:YLR181C
gene id: 559292:YLR181C
uniprot id: Q06263
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.
messages: Homodimer (in cytoplasm). Interacts with VPS4; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex; the interaction is ADP-dependent. Interacts with SNF7; the interaction requires DID2. Interacts with DID2. Interacts with VPS60; the interaction occurs at he endosomal membrane.
messages: Present with 4400 molecules/cell in log phase SD medium.

559292:YML048W
gene id: 559292:YML048W
uniprot id: Q04697
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: May be involved in the secretion of hexose transporters from the endoplasmic reticulum. Involved in secretion of GAL2 and HXT1.
messages: Present with 21400 molecules/cell in log phase SD medium.

559292:YLR009W
gene id: 559292:YLR009W
uniprot id: Q07915
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with nucleolar and cytoplasmic pre-60S particles (PubMed:12808088). At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (PubMed:12808088, PubMed:23185031). Interacts (via C-terminus) with AFG2 (hexameric form); the interaction is direct, recruits AFG2 to pre-60S ribosomal particles and promotes AFG2 ATPase activity and RLP24 release from pre-60S ribosomal particles (PubMed:23185031). Interacts with NOG1; the interaction is direct (PubMed:12808088).
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Cytoplasm
messages: Involved in the biogenesis of the 60S ribosomal subunit (PubMed:12808088, PubMed:23185031). Ensures the docking of NOG1 to pre-60S ribosomal particles (PubMed:12808088). Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles (PubMed:23185031).
messages: Nucleus

559292:YGR145W
gene id: 559292:YGR145W
uniprot id: P48234
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: Component of the 90S pre-ribosomes.
messages: May be involved in rRNA-processing and ribosome biosynthesis.
messages: nucleolus

559292:YGL171W
gene id: 559292:YGL171W
uniprot id: P45818
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. May also have a gene-specific regulatory function since it affects nuclear fusion by regulating KAR4 expression and contributes with KEM1 to ISP-1 sensitivity.
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes. This association requires the presence of RRP5. Interacts also with OSH3.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YBR202W
gene id: 559292:YBR202W
uniprot id: P38132
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer. Interacts with CSM1 and MCM10.
messages: Cytoplasm
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus
messages: Present with 166 molecules/cell in log phase SD medium.

559292:YFL003C
gene id: 559292:YFL003C
uniprot id: P40965
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Heterooligomer of MSH4 and MSH5.
messages: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.
messages: Two distinct classes of crossovers have been demonstrated in budding yeast. Class I is MSH4/MSH5 dependent and exhibits crossover interference. Class II is MUS81/MMS4 dependent and exhibits no interference.

559292:YDR039C
gene id: 559292:YDR039C
uniprot id: Q01896
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.
messages: Cell membrane
messages: Present with 639 molecules/cell in log phase SD medium.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithiums ions to allow salt tolerance.

559292:YDR060W
gene id: 559292:YDR060W
uniprot id: Q12176
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CBF/MAK21 family.
messages: Interacts with NOC2. Forms a nucleolar complex with NOC2 that binds to 90S and 66S pre-ribosomes.
messages: Present with 15000 molecules/cell in log phase SD medium.
messages: Required for 60S ribosomal subunit synthesis.
messages: nucleolus

559292:YCL045C
gene id: 559292:YCL045C
uniprot id: P25574
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.
messages: Endoplasmic reticulum membrane
messages: N-glycosylated.
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YDL090C
gene id: 559292:YDL090C
uniprot id: P22007
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X where X is Ser, Ala, Met, Cys, or Gln. Required for the membrane localization of proteins such as a-factor, Ras proteins and other membrane proteins containing the C-terminal CAAX motif (PubMed:3533274, PubMed:2124698, PubMed:1860864, PubMed:1763050, PubMed:8424764, PubMed:8527442, PubMed:17142567). The beta subunit is responsible for isoprenoid and peptide-binding (PubMed:7878044, PubMed:8995312, PubMed:9380709, PubMed:9545274, PubMed:12667062).
messages: Cytoplasm
messages: Decreases SKT5 farnesylation.
messages: Heterodimer of an alpha (RAM2) and a beta (RAM1) subunit.
messages: Present with 3910 molecules/cell in log phase SD medium.

559292:YAL054C
gene id: 559292:YAL054C
uniprot id: Q01574
names: Caution
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: By acetate, acetaldehyde and ethanol. Subject to glucose catabolite repression. Inactivated and degraded after addition of glucose (at protein level).
messages: Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. 'Aerobic' isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate.
messages: Cytoplasm
messages: It is uncertain whether Met-1 or Met-25 is the initiator.
messages: Microsome
messages: Mitochondrion
messages: Nucleus
messages: Present with 2890 molecules/cell in log phase SD medium.
messages: The FACS motif is required for catalytic activity and substrate specificity.

559292:YFL016C
gene id: 559292:YFL016C
uniprot id: P35191
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Plays a role in mitochondrial biogenesis and protein folding.
messages: Present with 7570 molecules/cell in log phase SD medium.

559292:YJR104C
gene id: 559292:YJR104C
uniprot id: P00445
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer in holo form. In apo form, heterodimer with CCS1. Zinc-binding at 'His-16' of CCS1 and Glu-43 of apo-SOD1 is required for this heterodimerization.
messages: Mitochondrion intermembrane space
messages: Present with 519000 molecules/cell in log phase SD medium.

559292:YCR072C
gene id: 559292:YCR072C
uniprot id: P25382
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle (PubMed:16702403, PubMed:18658244, PubMed:19737519). Interacts (via WD repeats) with uL18 (RPL5) (PubMed:25404745). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (PubMed:19737519, PubMed:20542003). Interacts (via WD repeats) with NSA2 (PubMed:25404745).
messages: Belongs to the NLE1/RSA4 family.
messages: Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin (MDN1/REA1), which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.
messages: nucleolus

559292:YCR032W
gene id: 559292:YCR032W
uniprot id: P25356
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in protein sorting and cell wall formation.
messages: Membrane

559292:YBR055C
gene id: 559292:YBR055C
uniprot id: P19735
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Nucleus
messages: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
messages: Present with 2250 molecules/cell in log phase SD medium.

559292:YDL222C
gene id: 559292:YDL222C
uniprot id: Q07651
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUR7 family.
messages: By osmotic and salt stresses.
messages: Cell membrane
messages: Involved in sporulation and affects the sphingolipid composition of the plasma membrane.
messages: Present with 329 molecules/cell in log phase SD medium.

559292:YBR031W
gene id: 559292:YBR031W
uniprot id: P10664
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL4 is associated with the polypeptide exit tunnel (PubMed:9559554, PubMed:22096102). uL4 interacts with its chaperone ACL4 and the nuclear import receptor KAP104 (PubMed:25936803).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uL4 participates in the regulation of the accumulation of its own mRNA (PubMed:2065661).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Nucleus
messages: The eukaryote-specific C-terminal extension harbors a nuclear import signal and delivers the ACL4-uL4/RPL4 complex to the pre-ribosome, triggering uL4 release from ACL4 and incorporation into the 60S ribosomal subunit.
messages: There are 2 genes for uL4 in yeast.

559292:YNL271C
gene id: 559292:YNL271C
uniprot id: P41832
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the formin homology family. BNI1 subfamily.
messages: Cell membrane
messages: Each FH2 dimer contains binding sites for 4 actin molecules.
messages: Homodimer, and possibly also homotetramer. Interacts with PFY1 via the FH1 domain and with actin via the FH2 domain.
messages: Present with 166 molecules/cell in log phase SD medium.
messages: Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Potential target of the RHO family members.
messages: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
messages: cytoskeleton
messages: ruffle membrane

559292:YDR204W
gene id: 559292:YDR204W
uniprot id: O13525
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ3.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides.
messages: Mitochondrion inner membrane

559292:YML064C
gene id: 559292:YML064C
uniprot id: P38987
names: Function
names: Miscellaneous
names: Subunit
messages: GTP-binding protein involved in termination of M phase. May play a role in triggering the degradation of G2 cyclin to inactivate M-phase promoting factor at the termination of mitosis. Acts upstream of CDC15 kinase and may be required to activate the CDC15 protein kinase pathway.
messages: Interacts with CDC15 and AMN1. AMN1 and CDC15 compete for association with TEM1.
messages: Present with 573 molecules/cell in log phase SD medium.

559292:YDR150W
gene id: 559292:YDR150W
uniprot id: Q00402
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Additional regions of lower homology to the repeat consensus (always starting with proline) are found in both flanking domains of the tandem repeats.
messages: Bud tip
messages: Controls nuclear migration. NUM1 specifically controls the interaction of the bud neck cytoskeleton with the pre-divisional G2 nucleus. Functions in dynein-anchoring. During late anaphase forms dynein-interacting cortical microtubule capture sites at both cellular poles. This leads to dynein-dependent sliding of the microtubules in the bud.
messages: Interacts with PAC11 when DYN1 is present, and TUB3.

559292:YDR303C
gene id: 559292:YDR303C
uniprot id: Q06639
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is required for transcription of ribosomal protein genes and genes involved in the integrity of the cell wall, and also for proper metaphase progression. Together with HTL1, LDB7, NPL6, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity.
messages: Forms a heteromer with RSC30. Interacts with LDB7 and NPL6. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Component of a fungal-specific module (HTL1-LDB7-NPL6-RSC3-RSC30) within the RSC complex.
messages: Nucleus
messages: Present with 1750 molecules/cell in log phase SD medium.

559292:YNL325C
gene id: 559292:YNL325C
uniprot id: P42837
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold.
messages: Present with 339 molecules/cell in log phase SD medium.
messages: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Major enzyme required for hyperosmotic shock-induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function. In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control. In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol 3,5-bisphosphate.
messages: Vacuole membrane

559292:YBR119W
gene id: 559292:YBR119W
uniprot id: P32605
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM U1 A/B'' family.
messages: Component of the spliceosome where it is associated with snRNP U1.
messages: Involved in nuclear mRNA splicing. The principal role of the U1A is to help fold or maintain U1 RNA in an active configuration. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP.
messages: Nucleus
messages: Present with 2950 molecules/cell in log phase SD medium.

559292:YPL123C
gene id: 559292:YPL123C
uniprot id: Q02933
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Cytoplasm
messages: N-glycosylated.
messages: Present with 504 molecules/cell in log phase SD medium.
messages: Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.
messages: Up-regulated by heat shock and osmotic stress.
messages: Vacuole lumen

559292:YLR036C
gene id: 559292:YLR036C
uniprot id: Q07986
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 967 molecules/cell in log phase SD medium.

559292:YMR229C
gene id: 559292:YMR229C
uniprot id: Q05022
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.
messages: Present with 8860 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR298C
gene id: 559292:YLR298C
uniprot id: Q05900
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: Present with 2140 molecules/cell in log phase SD medium.
messages: U1 snRNP is composed of the 7 core Sm proteins SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively) that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 10 U1 snRNP-specific proteins SNP1/U1-70K, MUD1/U1-A, YHC1/U1-C, LUC7, NAM8, PRP39, PRP40, PRP42, SNU56 and SNU71. YHC1/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

559292:YDR109C
gene id: 559292:YDR109C
uniprot id: Q04585
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway.

559292:YHR105W
gene id: 559292:YHR105W
uniprot id: P38815
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YPT35 family.
messages: Decreases VPS13 levels at endosomal membranes and nuclear envelope-vacuole contact sites.
messages: Endosome membrane
messages: Interacts (via PxP motif) with VPS13 (via SHR-BD domain) (PubMed:30018089). Interacts with RBD2 (PubMed:15263065). Interacts with YIF1 (PubMed:15263065). Interacts with YIP1 (PubMed:15263065). Interacts with YIP4 (PubMed:15263065).
messages: Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
messages: The PX domain binds phosphatidylinositol 3-phosphate (PtdIns(3)P) which is necessary for peripheral membrane localization.
messages: Vacuole membrane

559292:YLL001W
gene id: 559292:YLL001W
uniprot id: P54861
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Interacts with FIS1 and MDV1.
messages: Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1.
messages: Mitochondrion outer membrane
messages: Present with 9600 molecules/cell in log phase SD medium.
messages: The GTPase domain modulates a rate-limiting step in mitochondrial membrane fission.

559292:YLL004W
gene id: 559292:YLL004W
uniprot id: P54790
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with ORC6.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
messages: Nucleus

559292:YJR046W
gene id: 559292:YJR046W
uniprot id: P47112
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the MCM2-7 complex. Interacts with MCM2, ORC1, ORC2 and ORC6.
messages: Belongs to the Cdt1 family.
messages: Cytoplasm
messages: DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM2-7 helicase complex to the replication origins.
messages: Nucleus
messages: Present with 2190 molecules/cell in log phase SD medium.

559292:YOL125W
gene id: 559292:YOL125W
uniprot id: Q12383
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase TRM13 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1230 molecules/cell in log phase SD medium.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

559292:YPL201C
gene id: 559292:YPL201C
uniprot id: Q08956
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in the regulation of anaerobiotic glycerol metabolism.
messages: Nucleus

559292:YGL031C
gene id: 559292:YGL031C
uniprot id: P04449
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 247000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL24 in yeast.

559292:YJL127C
gene id: 559292:YJL127C
uniprot id: P35208
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Decreases HTA1 RNA level.
messages: Present with 1500 molecules/cell in log phase SD medium.
messages: Required for normal transcription at a number of loci in yeast. Affects transcription at Ty1 elements, at PHO5, STE6 and ADH2.

559292:YNL229C
gene id: 559292:YNL229C
uniprot id: P23202
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily.
messages: Cytoplasm
messages: Homodimer. Interacts with NNK1.
messages: Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) activities.
messages: Present with 7060 molecules/cell in log phase SD medium.
messages: The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
messages: [URE3] is the prion form of URE2. [URE3] is the result of a conformational change of the cellular URE2 protein that becomes self-propagating and infectious. This conformational change generates a form of URE2 that assembles into amyloid fibrils. [URE3]-aggregates sequester soluble URE2, which then fails to retain GLN3 in the cytoplasm, resulting in GLN3 activation and consequently derepression of genes that are required for utilization of poor nirogen sources (PubMed:7909170). [URE3] can be cured by GdnHCl and by deletion of the molecular chaperone HSP104, which is required for [URE3] propagation (PubMed:11073991).

559292:YKR072C
gene id: 559292:YKR072C
uniprot id: P36024
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.
messages: Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis. Acts as an inhibitory subunit of protein phosphatase PPZ1, which is involved in many cellular processes such as G1-S transition or salt tolerance. Also modulates the expression of the ENA1 ATPase.
messages: Cytoplasm
messages: Interacts with the C-terminal domain of PPZ1. Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex, a heterotrimer composed of CAB3, SIS2 and VHS3.
messages: Nucleus
messages: Present with 3750 molecules/cell in log phase SD medium.

559292:YML010W
gene id: 559292:YML010W
uniprot id: P27692
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Chromosome
messages: Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II. Interacts with SHE2.
messages: It is phosphorylated in a PKA-dependent manner in vitro.
messages: Mitochondrion
messages: Nucleus
messages: Present with 2340 molecules/cell in log phase SD medium.
messages: The C-terminal repeats are critical for activity.
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
messages: Was originally thought to be involved in the transcription initiation step.

559292:YHR052W
gene id: 559292:YHR052W
uniprot id: P38779
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: An adapter protein that specifically links the 26S proteasome to its substrate CDC4 which is one of the substrate recognition subunits of the SCF E3 ubiquitin ligase complex. Required for turnover of cell cycle regulatory proteins CDC4 and GRR1. Required for synthesis and nuclear export of 60S ribosomal subunits. Required for vegetative growth.
messages: Interacts with CDC4, PRE4, PRE6, RPT1 and SCL1 as part of the fully assembled 26S proteasome. Interacts with pre-ribosomal particles constituent NOP7.
messages: Present with 45900 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YKR082W
gene id: 559292:YKR082W
uniprot id: P36161
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup133 family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP133 is part of the heptameric 0.5 MDa autoassembling NUP84 NPC subcomplex (NUP84, NUP85, NUP120, NUP133, NUP145C, SEC13 and SEH1).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP133 is involved in nuclear poly(A)+ RNA, tRNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.
messages: Nucleus membrane
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: Usually mRNA binding pumilio repeats come in 8 copies. In the 8-fold symmetry of the NPC the 8 repeats may be provided by eight copies of NUP133.
messages: nuclear pore complex

559292:YOL055C
gene id: 559292:YOL055C
uniprot id: Q08224
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: By absence of thiamine.
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probably that of HMP to HMP-P.
messages: In the C-terminal section; belongs to the thiaminase-2 family.
messages: In the N-terminal section; belongs to the ThiD family.
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YHR072W-A
gene id: 559292:YHR072W-A
uniprot id: Q6Q547
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP10 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) (PubMed:9843512, PubMed:21131909). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10 (PubMed:9843512, PubMed:21131909). The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind (PubMed:9843512).
messages: Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9843512).
messages: nucleolus

559292:YDR541C
gene id: 559292:YDR541C
uniprot id: Q03049
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

559292:YJR113C
gene id: 559292:YJR113C
uniprot id: P47150
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 1340 molecules/cell in log phase SD medium.

559292:YKL164C
gene id: 559292:YKL164C
uniprot id: Q03178
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIR protein family.
messages: Component of the outer cell wall layer. Required for stability of the cell wall and for optimal growth. Required for resistance against several antifungal and cell wall-perturbing agents and for tolerance to heat shock.
messages: Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from specific glutamines within the PIR1/2/3 repeats, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
messages: O-glycosylated. Extensively O-mannosylated.
messages: Positively regulated by signaling through MPK1 in response to cell wall perturbation. Expression is also regulated by the SWI5 transcription factor.
messages: Present with 1170 molecules/cell in log phase SD medium.
messages: The PIR1/2/3 repeats are required for covalent linkage to the cell wall (By similarity). Their number varies among different strains of S.cerevisiae.
messages: cell wall

559292:YCR004C
gene id: 559292:YCR004C
uniprot id: P25349
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WrbA family.
messages: Cytoplasm
messages: Membrane raft
messages: Mitochondrion
messages: Present with 14600 molecules/cell in log phase SD medium.

559292:YOL086W-A
gene id: 559292:YOL086W-A
uniprot id: Q3E835
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: The MHF histone-fold complex is a heterotetramer of 2 MHF1-MHF2 heterodimers. Together with MPH1/FANCM, forms the FANCM-MHF complex. Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (Probable).
messages: dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (PubMed:20347428). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:22561346).

559292:YLR159W
gene id: 559292:YLR159W
uniprot id: P0CE96
uniprot id: P0CE97
uniprot id: P0CE98
names: Miscellaneous
messages: There are 3 tandem-duplicated genes coding for this protein in S.cerevisiae (YLR156W, YLR159W and YLR161W). Additionally, a fourth copy has been disrupted by a Ty1 retrotransposon, which led to the prediction of the 2 dubious ORFs YLR157W-D and YLR157W-E.

559292:YKL072W
gene id: 559292:YKL072W
uniprot id: P36085
names: Function
names: Miscellaneous
names: Similarity
messages: Binds to SIN3.
messages: Present with 211 molecules/cell in log phase SD medium.
messages: To yeast STB2.

559292:YOL103W-B
gene id: 559292:YOL103W-B
uniprot id: Q12273
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YOL103W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YKL149C
gene id: 559292:YKL149C
uniprot id: P24309
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It also participates in Ty1 retrovirus-like transposition via an RNA lariat intermediate in cDNA synthesis.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1130 molecules/cell in log phase SD medium.

559292:YPR165W
gene id: 559292:YPR165W
uniprot id: P06780
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1,3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7.
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by the guanine nucleotide-exchange factors (GEFs) ROM1, ROM2 and TUS1, and inactivated by GTPase-activating proteins (GAPs) BAG7, BEM2, LRG1, and SAC7, and the Rho GDP-dissociation inhibitor RDI1. The different GAPs regulate RHO1 in a target-specific manner.
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Endosome membrane
messages: Interacts with BEM4; the interaction is direct (PubMed:8754839, PubMed:8754840). Interacts with SEC3; the interaction is direct (PubMed:11283608). Interacts with the GAP BAG7 (PubMed:11591390, PubMed:12207708). Interacts with the GAP LRG1 (PubMed:11447600). Interacts with the GAP SAC7 (PubMed:11447600, PubMed:9038344). Interacts with the GAP RDI1 (PubMed:9242378). Interacts with the 1,3-beta-glucan synthase component FKS1 (PubMed:8602515). Interacts with the protein kinase PKC1 (PubMed:8621575, PubMed:8846785). Interacts with the G protein beta subunit STE4 (PubMed:12660244). Interacts with SKN7 (PubMed:9535835). Interacts with TUS1 (PubMed:11839800). Interacts with BNI1 (PubMed:8947028).
messages: Peroxisome membrane

559292:YBR222C
gene id: 559292:YBR222C
uniprot id: P38137
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: By oleic acid.
messages: Catalyzes the first step in a degradation pathway of oxalate to CO(2) to protect the cell against the harmful effects of oxalate derived from endogenous processes or an environmental sources.
messages: Decreases recovery from exposure to oxalate, to oxalate-secreting microbes, and to oxidative stress.
messages: Interacts with PEX5.
messages: Peroxisome matrix
messages: Peroxisome membrane
messages: Present with 8770 molecules/cell in log phase SD medium.
messages: The FACS motif is required for catalytic activity and substrate specificity.

559292:YGL256W
gene id: 559292:YGL256W
uniprot id: P10127
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Homodimer.
messages: Induced by transcription factor ZAP1 in response to zinc deficiency.
messages: Inhibited by EDTA.
messages: Mitochondrion
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Reduces acetaldehyde to ethanol during glucose fermentation. Specific for ethanol. Shows drastically reduced activity towards primary alcohols from 4 carbon atoms upward. Isomers of aliphatic alcohol, as well as secondary alcohols and glycerol are not used at all.
messages: While ADH4 is expressed at only low levels in laboratory strains, it is often highly expressed in brewing strains.
messages: Zinc. May bind iron when zinc levels are limiting.

559292:YLR239C
gene id: 559292:YLR239C
uniprot id: Q06005
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity).
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
messages: Mitochondrion
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YDR176W
gene id: 559292:YDR176W
uniprot id: P32494
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGG1 family.
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9. Component of the ADA/GCN5 complex that consists of HFI1/ADA1, ADA2, ADA3, SPT20/ADA5 and GCN5 and is probably a subcomplex of SAGA. Component of the 0.8 MDa ADA complex, which at least consists of ADA2, ADA3, AHC1 and GCN5.
messages: Nucleus
messages: Present with 2470 molecules/cell in log phase SD medium.
messages: Transcription regulator. Could inhibit GAL4 DNA-binding or its ability to activate transcription. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B.

559292:YER050C
gene id: 559292:YER050C
uniprot id: P40033
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 1210 molecules/cell in log phase SD medium.

559292:YBR204C
gene id: 559292:YBR204C
uniprot id: P38139
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Leads to the appearance of giant lipid droplets and an excessive accumulation of non-polar lipids and phospholipids upon growth on medium containing oleic acid as a sole carbon source.
messages: Lipid droplet
messages: Serine hydrolase required for the maintenance of steady state level of non-polar and polar lipids of lipid droplets and thus plays a role in maintaining the lipids homeostasis (PubMed:21478434). Exhibits both esterase and triacylglycerol lipase activity (PubMed:21478434).

559292:YOR256C
gene id: 559292:YOR256C
uniprot id: Q08693
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Membrane
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YIL153W
gene id: 559292:YIL153W
uniprot id: P40454
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: Interacts with the phosphatase PP2A-like catalytic subunits PPG1, PPH3 and SIT4. Forms a ternary complex with SIT4-TAP42.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Involved in the regulation of cell cycle progression, mitotic spindle formation, bud morphogenesis and DNA repair.
messages: Present with 4590 molecules/cell in log phase SD medium.
messages: Sensitive to high hydrostatic pressure (mechanical stress); simultaneous disruption of SCH9 exacerbates the effect.

559292:YBR153W
gene id: 559292:YBR153W
uniprot id: P33312
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
messages: Cells lacking this gene accumulate a 6-hydroxy-2,4,5-triaminopyrimidine derivative.
messages: Homodimer.

559292:YLR061W
gene id: 559292:YLR061W
uniprot id: P05749
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 60400 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL22 in yeast.

559292:YLL066C
gene id: 559292:YLL066C
uniprot id: Q99208
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YAL062W
gene id: 559292:YAL062W
uniprot id: P39708
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

559292:YOR137C
gene id: 559292:YOR137C
uniprot id: Q12212
names: Function
names: Induction
messages: Involved in the activation of the plasma membrane proton-ATPase (PMA1) by glucose.
messages: Up-regulated by ethanol.

559292:YJL134W
gene id: 559292:YJL134W
uniprot id: P47013
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type 2 lipid phosphate phosphatase family.
messages: Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases (PubMed:10477278, PubMed:10563329, PubMed:10856228, PubMed:11278643, PubMed:11967828, PubMed:12493772, PubMed:12684378, PubMed:12786943, PubMed:9195906, PubMed:9353337, PubMed:9419344, PubMed:25345524). Involved in endocytosis and calcium-mediated signaling (PubMed:10856228, PubMed:11278643).
messages: Endoplasmic reticulum membrane
messages: Glycosylated.

559292:YCL011C
gene id: 559292:YCL011C
uniprot id: P25555
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus (PubMed:14769921, PubMed:24452287). Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded. On correctly spliced mRNAs, GBP2 and HRB1 recruit MEX67 to allow nuclear export. On faulty mRNAs, GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation (PubMed:24452287). Binds single-stranded telomeric sequences of the type (TG[1-3])n in vitro (PubMed:7800479). Influences the localization of RAP1 in the nuclei (PubMed:7777547). Involved in modulating telomere length (PubMed:12519786).
messages: Cytoplasm
messages: Methylated by HMT1.
messages: Nucleus
messages: P-body
messages: Present with 2540 molecules/cell in log phase SD medium.
messages: RRM 1 and RRM 2 recognize preferentially RNAs containing the core motif GGUG. The atypical C-terminal RRM domain (RRM 3) does not interact with RNA/DNA, but is crucial for interaction with the THO/TREX complex.
messages: Stress granule
messages: telomere

559292:YCL019W
gene id: 559292:YCL019W
uniprot id: P25384
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YCL020W ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YIR034C
gene id: 559292:YIR034C
uniprot id: P38998
names: Activity Regulation
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysine biosynthesis.
messages: Induced by alpha-aminoadipate semialdehyde in a LYS14-dependent manner. Repressed by lysine.
messages: Inhibited by p-chloromercuribenzoate and iodoacetate by modification of the active site cysteine residue. Inhibited by diethyl pyrocarbonate by modification of histidine residues. Inhibited by pyridoxal 5'-phosphate by modification of an essential lysine residue.
messages: Monomer.
messages: Peroxisome
messages: Present with 111934 molecules/cell in log phase SD medium.
messages: PubMed:10077615 shows data confirming the peroxisomal localization of the protein, however this study was later retracted as the images were additionally used in other articles for other proteins.

559292:YMR233W
gene id: 559292:YMR233W
uniprot id: Q05024
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in transcription regulation.
messages: Nucleus
messages: Present with 2360 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YBR189W
gene id: 559292:YBR189W
uniprot id: P05755
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS4 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). Interacts with snoRNA U3. uS11 interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).
messages: Cytoplasm
messages: Present with 63300 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS4 in yeast.
messages: nucleolus

559292:YLR201C
gene id: 559292:YLR201C
uniprot id: Q05779
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion inner membrane
messages: Present with 3420 molecules/cell in log phase SD medium.

559292:YER056C
gene id: 559292:YER056C
uniprot id: P17064
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane
messages: Not N-glycosylated.
messages: Present with 23600 molecules/cell in log phase SD medium.
messages: This permease has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine.

559292:YML097C
gene id: 559292:YML097C
uniprot id: P54787
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: Required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. May bind a Rab GTPase such as VPS21.
messages: The CUE domain (Coupling of ubiquitin conjugation to ER degradation) is monoubiquitin-binding and is required for intramolecular ubiquitination.

559292:YLR105C
gene id: 559292:YLR105C
uniprot id: P16658
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:9200603, it contains a transmembrane domain and may be responsible to anchor the complex into membranes, however, PubMed:12925762 showed that it is peripherically associated with membranes, and is probably not a transmembrane protein.
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. This subunit may anchor the endonuclease complex to the nuclear membrane. Probably carries the active site for 5'-splice site cleavage.
messages: Endomembrane system
messages: Heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN54.
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Present with 319 molecules/cell in log phase SD medium.
messages: The tRNA splicing endonuclease complex is present with 100 molecules/cell.

559292:Q0045
gene id: 559292:Q0045
uniprot id: P00401
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX1 is a catalytic core subunit containing heme A and the active site BNC with heme A3 and the copper atom CU(B) (PubMed:30598554).
messages: Mitochondrion inner membrane
messages: The N-terminus is blocked.

559292:YMR180C
gene id: 559292:YMR180C
uniprot id: Q03220
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal TPase family.
messages: Cytoplasm
messages: Magnesium and/or manganese. Specific for polynucleotide RNA in the presence of magnesium, but becomes specific for nucleotide triphosphates in the presence of manganese.
messages: Nucleus
messages: Probably involved in an RNA processing event other than mRNA capping. Releases gamma-phosphate from the 5'-end of RNA to produce a diphosphate terminus.

559292:YGL209W
gene id: 559292:YGL209W
uniprot id: P53035
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the creA/MIG C2H2-type zinc-finger protein family.
messages: Involved in glucose repression of the SUC2 gene.
messages: Nucleus
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YDR194C
gene id: 559292:YDR194C
uniprot id: P15424
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Specifically involved in the ATP-dependent splicing of the bl1 intron of COB. Also required for efficient mitochondrial translation.
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: Mitochondrion matrix
messages: Present with 10300 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

559292:YOR237W
gene id: 559292:YOR237W
uniprot id: P35843
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Bud neck
messages: Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis. Plays a role in ergosterol synthesis (PubMed:15173322, PubMed:11238399, PubMed:16408938, PubMed:20008566). Binds and transports sterol (PubMed:20008566). May be involved in ergosterol transport from the plasma membrane (PM) to the ER (PubMed:16585271).
messages: Present with 1690 molecules/cell in log phase SD medium.
messages: The OSBP-related domain (ORD) mediates binding of sterols and phospholipids. It displays an incomplete beta-barrel containing a central hydrophobic tunnel that can accommodate a single lipid molecule with a flexible lid covering the tunnel entrance. The ORD can bind two membranes simultaneously. It has at least two membrane-binding surfaces; one near the mouth of the lipid-binding pocket and a distal site that can bind a second membrane. These structural features correlate with the phosphatidylinositol 4-phosphate (PI(4)P)-coupled lipid transport optimized in closely apposed membranes, such as organelle contact sites. The lipid transfer cycle starts from the association of the LTP with a donor membrane, which accompanies conformational changes that uncover the ligand-binding pocket. The tunnel opening is generally mediated by displacement of the lid covering the binding pocket allowing uptake or release of a lipid molecule. The LTPs extract the lipid from the membrane by providing a hydrophobic environment as well as specific interaction. Dissociation from the donor membrane shifts the conformation to a closed form. Then, the LTPs loaded with a cargo lipid diffuse through the aqueous phase. Lid opening may be induced by the interaction of a hydrophobic side of the lid with the target membranes.
messages: Vacuole membrane

559292:YGL093W
gene id: 559292:YGL093W
uniprot id: P53148
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SPC105 complex composed of at least SPC105 and KRE28. The SPC105 complex interacts with the MIND and NDC80 complexes at the centromere.
messages: Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.
messages: Nucleus membrane
messages: kinetochore
messages: spindle pole body

559292:YER035W
gene id: 559292:YER035W
uniprot id: P40023
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.
messages: mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2.

559292:YDR034W-B
gene id: 559292:YDR034W-B
uniprot id: Q6Q5X2
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane
messages: Present with 861 molecules/cell in log phase SD medium.
messages: cell cortex

559292:YML070W
gene id: 559292:YML070W
uniprot id: P54838
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.
messages: Present with 23600 molecules/cell in log phase SD medium.

559292:YBL005W-A
gene id: 559292:YBL005W-A
uniprot id: Q12266
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-BL is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YCL048W
gene id: 559292:YCL048W
uniprot id: P25380
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Redundant with SPS2 for the organization of the beta-glucan layer of the spore wall.

559292:YDR255C
gene id: 559292:YDR255C
uniprot id: Q12508
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase component of the GID complex (PubMed:12686616, PubMed:18508925). Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:9737955, PubMed:18508925). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:9737955, PubMed:12686616, PubMed:18508925, PubMed:28126757).
messages: Identified in the GID complex. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is induced and becomes part of the complex (PubMed:22645139). Interacts with FYV10/GID9; the interaction is direct (PubMed:22044534). Within the GID complex, interacts directly with GID8, FYV10/GID9 and VID28/GID5 (PubMed:22645139).

559292:YLL056C
gene id: 559292:YLL056C
uniprot id: Q12177
names: Induction
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Highly induced under sulfur starvation conditions.

559292:YGL142C
gene id: 559292:YGL142C
uniprot id: P30777
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family. PIGB subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.

559292:YFR009W
gene id: 559292:YFR009W
uniprot id: P43535
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as a positive activator of the GCN2 protein kinase activity in response to in response to low amino acid, carbon, or purine availability (PubMed:7621831, PubMed:10733573). Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes; during this process, GCN20 helps GCN1 to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity (PubMed:7621831, PubMed:9234705, PubMed:10775272, PubMed:15722345). Participates in gene-specific mRNA translation activation, such as the transcriptional activator GCN4, by promoting the GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) on 'Ser-52', and hence allowing GCN4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:15722345).
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Inhibits GCN4 derepression in amino acid or purine-starved cells (PubMed:10733573). Attenuates GCN4 derepression in glucose-starved cells (PubMed:10733573).
messages: Interacts (via N-terminus) with GCN1 (via C-terminus); this interaction stimulates GCN2 kinase activity in response to amino acid starvation (PubMed:7621831, PubMed:9234705, PubMed:11101534, PubMed:15722345). The GCN1-GCN20 complex interacts with GCN2 on translating ribosomes in amino acid-starved cells; this association stimulates GCN2 kinase activation by uncharged tRNAs, and hence allowing GCN4 translational activation and derepression of amino acid biosynthetic genes (PubMed:7621831, PubMed:9234705, PubMed:10775272, PubMed:11101534). Associates with ribosomes (PubMed:7621831, PubMed:9234705, PubMed:15722345).
messages: Present with 14600 molecules/cell in log phase SD medium.

559292:YPL160W
gene id: 559292:YPL160W
uniprot id: P26637
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Present with 158000 molecules/cell in log phase SD medium.

559292:YER127W
gene id: 559292:YER127W
uniprot id: P40079
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 of the pre-ribosomal RNA. Participates in ribosome biogenesis.
messages: Present with 1430 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YIL160C
gene id: 559292:YIL160C
uniprot id: P27796
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Homodimer (PubMed:7812714, PubMed:9402066). Interacts (via PTS2-type peroxisomal targeting signal region) with PEX7; leading to its translocation into peroxisomes (PubMed:23812376).
messages: Mitochondrion intermembrane space
messages: Peroxisome
messages: Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs).
messages: The PTS2-type peroxisomal targeting signal, which mediates interaction with PEX7 and localization to peroxisomes, is cleaved following import into peroxisomes.

559292:YJR072C
gene id: 559292:YJR072C
uniprot id: P47122
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Cytoplasm
messages: Heterodimers with GPN2 or GPN3 (PubMed:23324351, PubMed:23267056). Binds to RNA polymerase II (RNAPII) in a GTP-dependent manner (PubMed:20855544, PubMed:21844196). Interacts with nuclear pore protein NUP133 and nuclear export factor CRM1 (PubMed:21844196). Interacts with PCL1 (PubMed:15082539).
messages: Phosphorylated by the cyclin-CDK PCL1-PHO85.
messages: Present with 15200 molecules/cell in log phase SD medium.
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21844196). May act at an RNAP assembly step prior to nuclear import (PubMed:23267056). Promotes sister chromatid separation during anaphase (PubMed:21532343).

559292:YMR122W-A
gene id: 559292:YMR122W-A
uniprot id: Q3E842
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 49500 molecules/cell in log phase SD medium.

559292:YJL161W
gene id: 559292:YJL161W
uniprot id: P46998
names: Induction
names: Subcellular Location Annotation
messages: By cell wall perturbation.
messages: Mitochondrion membrane

559292:YPL066W
gene id: 559292:YPL066W
uniprot id: Q12194
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Impairs the efficient localization of TUS1 to the bud neck at late anaphase.
messages: Present with 396 molecules/cell in log phase SD medium.
messages: Regulator of RHO1 signaling that acts as a cofactor required for the efficient localization of the TUS1 GTP exchange factor (GEF) for RHO1 to the bud neck during all phases of cytokinesis (PubMed:22344253). RHO1 is a key, essential hub protein in the cell wall integrity (CWI) pathway in which activated RHO1-GTP binds directly to and activates multiple different downstream effectors required for cell wall synthesis and actin assembly during cytokinesis (Probable).

559292:YDR525W-A
gene id: 559292:YDR525W-A
uniprot id: P56508
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Lipid droplet
messages: Membrane
messages: Present with 20400 molecules/cell in log phase SD medium.

559292:YLR384C
gene id: 559292:YLR384C
uniprot id: Q06706
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837, PubMed:31309145, PubMed:25569479). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:12424236). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368). ELP1/IKI3 binds to tRNA, mediating interaction of the elongator complex with tRNA (PubMed:24750273). Independently, may be involved in polarized exocytosis (PubMed:15780940).
messages: Cytoplasm
messages: Homodimer; dimerization promotes ELP1/IKI3 stability and elongator complex formation (PubMed:26261306). Component of the elongator complex which consists of ELP1/IKI3, ELP2, ELP3, ELP4, ELP5/IKI1 and ELP6 (PubMed:11435442, PubMed:11689709, PubMed:27974378, PubMed:27872205, PubMed:26261306). The elongator complex is composed of two copies of the Elp123 subcomplex (composed of ELP1/IKI3, ELP2 and ELP3) and two copies of the Elp456 subcomplex (composed of ELP4, ELP5/IKI1 and ELP6) (PubMed:27974378, PubMed:27872205, PubMed:25960406). The Elp123 subcomplex forms a two-lobed scaffold, which binds the Elp456 subcomplex asymmetrically (PubMed:27974378, PubMed:27872205). In the complex, ELP1/IKI3 interacts with ELP2 (PubMed:12139626). In each lobe, ELP2 is tightly sandwiched between ELP1/IKI3 and ELP3 (PubMed:31309145). The Elp123 subcomplex binds tRNA through ELP1/IKI3 and ELP3 and can bind 2 tRNAs simultaneously (PubMed:31309145). tRNA-binding induces conformational rearrangements which precisely position the targeted anticodon base in the active site (PubMed:31309145). The Elp456 subcomplex binds tRNA and has ATPase activity (PubMed:22343726). ELP1/IKI3 interacts with HRR25 and KTI12 (PubMed:25569479). Interacts with KTI11/DPH3 (PubMed:27694803).
messages: Loss of mcm5U (5-methoxycarbonylmethyl uridine) and ncm5U (5-carbamoylmethyl uridine) from tRNA.
messages: Nucleus
messages: Phosphorylation promotes the tRNA modification function of the elongator complex.
messages: Present with 10500 molecules/cell in log phase SD medium.
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

559292:YJR155W
gene id: 559292:YJR155W
uniprot id: P47182
names: Similarity
messages: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

559292:YFR038W
gene id: 559292:YFR038W
uniprot id: P43610
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.
messages: Is probably involved in a pathway contributing to genomic integrity.
messages: Nucleus

559292:YNL126W
gene id: 559292:YNL126W
uniprot id: P53540
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TUBGCP family.
messages: Interacts with TUB4, SPC72 and SPC97.
messages: Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB.
messages: Nucleus
messages: Present with 56 molecules/cell in log phase SD medium.
messages: spindle pole body

559292:YDR279W
gene id: 559292:YDR279W
uniprot id: Q05635
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family. Highly divergent.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: Present with 2340 molecules/cell in log phase SD medium.
messages: The RNase 2 complex is a heterotrimer composed of the catalytic subunit RNH201 and of the non-catalytic subunits RNH202 and RNH203.

559292:YHR187W
gene id: 559292:YHR187W
uniprot id: P38874
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP5 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin.
messages: Component of the elongator complex, which consists of ELP1/IKI3, ELP2, ELP3, ELP4, ELP5/IKI1 and ELP6 (PubMed:11435442, PubMed:11390369, PubMed:11689709, PubMed:27974378, PubMed:27872205). The elongator complex is composed of two copies of the Elp123 subcomplex (composed of ELP1/IKI3, ELP2 and ELP3) and two copies of the Elp456 subcomplex (composed of ELP4, ELP5/IKI1 and ELP6) (PubMed:27974378, PubMed:27872205). The Elp123 subcomplex forms a two-lobed scaffold, which binds the Elp456 subcomplex asymmetrically (PubMed:27974378, PubMed:27872205). In each lobe, ELP2 is tightly sandwiched between ELP1/IKI3 and ELP3 (PubMed:31309145). The Elp123 subcomplex binds tRNA through ELP1/IKI3 and ELP3 and can bind 2 tRNAs simultaneously (PubMed:31309145). tRNA-binding by the Elp123 subcomplex induces conformational rearrangements which precisely position the targeted anticodon base in the active site (PubMed:31309145). The Elp456 subcomplex binds tRNA and has ATPase activity (PubMed:22556426, PubMed:22343726). Interacts with KTI11/DPH3 (PubMed:18627462).
messages: Cytoplasm
messages: Nucleus
messages: Present with 3870 molecules/cell in log phase SD medium.
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

559292:YKL204W
gene id: 559292:YKL204W
uniprot id: P36041
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.
messages: Cytoplasm
messages: Interacts with SMY2, SYH1 and eIF4E.
messages: Present with 3240 molecules/cell in log phase SD medium.

559292:YMR106C
gene id: 559292:YMR106C
uniprot id: Q04437
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ku80 family.
messages: Heterodimer of YKU70/HDF1 and YKU80/HDF2. Interacts with SIR4.
messages: Nucleus
messages: Present with 358 molecules/cell in log phase SD medium.
messages: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
messages: telomere

559292:YKR106W
gene id: 559292:YKR106W
uniprot id: P36173
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: By iron depletion. Expressed at a very low level.
messages: Cell membrane
messages: Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway.
messages: Vacuole membrane

559292:YOR320C
gene id: 559292:YOR320C
uniprot id: Q12096
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GNT1 family.
messages: Golgi apparatus membrane
messages: N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.
messages: N-glycosylated.
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YLL048C
gene id: 559292:YLL048C
uniprot id: P32386
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Present with 3000 molecules/cell in log phase SD medium.
messages: Vacuolar class C ABC transporter which regulates the translocation of phosphatidylcholine to the vacuole lumen, the release of lumenal calcium stores, and acts as a negative regulator of vacuole fusion. Exhibits ATP-dependent bile acid transport.
messages: Vacuole membrane

559292:YIR031C
gene id: 559292:YIR031C
uniprot id: P21826
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allantoin metabolism-specific malate synthase involved in the recycling the glyoxylate generated during allantoin degradation by the ureidoglycollate (UG) hydrolase reaction.
messages: Belongs to the malate synthase family.
messages: Diminishes the ureidoglycollate hydrolase activity by 3 to 4 fold.
messages: Expression is insensitive to carbon catabolite repression, but highly sensitive to nitrogen catabolite repression (PubMed:8462696). Its expression is induced by allophanate or oxalurate (PubMed:3915539).
messages: Interacts with PEX9.
messages: Peroxisome matrix

559292:YPL006W
gene id: 559292:YPL006W
uniprot id: Q12200
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.
messages: Present with 521 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YPR169W
gene id: 559292:YPR169W
uniprot id: Q06214
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with BUD27 and GIS1.
messages: Present with 7750 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YNL305C
gene id: 559292:YNL305C
uniprot id: P48558
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family. LFG subfamily.
messages: Endoplasmic reticulum membrane
messages: Links the unfolded protein response and programmed cell death and mediates mitochondrial-dependent apoptosis (PubMed:21673659, PubMed:21673967). Induces cell death and disruption of the mitochondrial transmembrane potential via the mitochondrial phosphate carrier MIR1 (PubMed:21673659). Dispensible for starvation-induced autophagy (PubMed:21926971).
messages: Mitochondrion membrane
messages: No effect on autophagy during nitrogen starvation.
messages: Vacuole membrane

559292:YPR109W
gene id: 559292:YPR109W
uniprot id: Q06104
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Component of the Golgi/endosome-localized DSC E3 ligase complex composed of at least TUL1, DSC2, DSC3, UBX3, CDC48 and GLD1.
messages: Component of the Golgi/endosome-localized DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquinate Golgi/endosome membrane proteins (PubMed:29355480). Competes with VLD1 to determine the subcellular localizations of the DSC complex (PubMed:29355480). May be required for cell cycle progression (PubMed:12829295).
messages: Endosome membrane
messages: Expression is regulated by the metabolic and meiotic transcriptional regulator UME6.
messages: Golgi apparatus membrane

559292:YMR267W
gene id: 559292:YMR267W
uniprot id: P28239
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Homodimer that binds non-covalently to a protein complex in the inner mitochondrial membrane.
messages: Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis.
messages: Mitochondrion
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YML045W-A
gene id: 559292:YML045W-A
uniprot id: Q04706
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-ML1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YLR305C
gene id: 559292:YLR305C
uniprot id: P37297
names: Function
names: Miscellaneous
names: Similarity
messages: Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate. STT4 functions in PKC1 protein kinase pathway.
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Present with 846 molecules/cell in log phase SD medium.

559292:YHR083W
gene id: 559292:YHR083W
uniprot id: P14693
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which at least consists of SAM35, SAM37 and SAM50.
messages: Essential component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.
messages: Mitochondrion outer membrane
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YIL070C
gene id: 559292:YIL070C
uniprot id: P40513
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAM33 family.
messages: Homotrimer or homotetramer.
messages: Mitochondrion matrix
messages: Not known. Binds to the sorting sequence of cytochrome b2.
messages: Present with 4910 molecules/cell in log phase SD medium.

559292:YMR096W
gene id: 559292:YMR096W
uniprot id: Q03148
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: Defects cause some sensibility to 6-azauracil, an inhibitor of purine and pyrimidine biosynthetic enzymes, and methylene blue, a producer of singlet oxygen. These effects are probably due to the inability to synthesize pyridoxal 5'-phosphate.
messages: Homohexamer (PubMed:19523954). Interacts with AIM18 (PubMed:12271461).
messages: Shows increased synthesis after entry into stationary phase.

559292:YFL034C-A
gene id: 559292:YFL034C-A
uniprot id: P56628
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 74700 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL22 in yeast.

559292:YNL034W
gene id: 559292:YNL034W
uniprot id: P53963
names: Similarity
messages: To yeast YNL018c.

559292:YDR335W
gene id: 559292:YDR335W
uniprot id: P52918
names: Miscellaneous
names: Subunit
messages: Interacts with CEX1.
messages: Present with 3500 molecules/cell in log phase SD medium.

559292:YJL066C
gene id: 559292:YJL066C
uniprot id: P40364
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion membrane
messages: Present with 3390 molecules/cell in log phase SD medium.

559292:YKL071W
gene id: 559292:YKL071W
uniprot id: P36086
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

559292:YHR039C
gene id: 559292:YHR039C
uniprot id: P38694
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: Endoplasmic reticulum
messages: N-glycosylated.
messages: Present with 2500 molecules/cell in log phase SD medium.

559292:YIR032C
gene id: 559292:YIR032C
uniprot id: P32459
names: Caution
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the ureidoglycolate lyase family.
messages: Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.
messages: Homodimer.
messages: Subject to nitrogen catabolite repression.
messages: This enzyme was also named ureidoglycolate hydrolase in the literature. However, this is the recommended name of another enzyme (EC 3.5.1.116) acting on ureidoglycolate. To make the distinction between ammonia- or urea-releasing activities from ureidoglycolate, the use of this ambiguous name is deprecated.

559292:YBR046C
gene id: 559292:YBR046C
uniprot id: P38230
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

559292:YMR174C
gene id: 559292:YMR174C
uniprot id: P01094
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I34 family.
messages: Specific and potent inhibitor for yeast aspartic protease A (yscA). The proteinase acts as a folding template stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity.

559292:YMR073C
gene id: 559292:YMR073C
uniprot id: Q04772
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the cytochrome b5 family.
messages: Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.
messages: Involved in resistance to carboplatin and cisplatin. Is probably involved in a pathway contributing to genomic integrity.
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YLR037C
gene id: 559292:YLR037C
uniprot id: Q07987
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Component of the cell wall.
messages: Induced at low temperature and during anaerobic growth and completely repressed during aerobic growth. Induced at an early stage of fermentation and remains almost constant throughout the entire fermentation process.
messages: O-glycosylated.
messages: cell wall

559292:YJL204C
gene id: 559292:YJL204C
uniprot id: P39531
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Cell tip
messages: Cytoplasm
messages: Interacts with SKP1.
messages: Involved in recycling plasma membrane proteins internalized by endocytosis. Required for recycling of the v-SNARE SNC1.
messages: Present with 2700 molecules/cell in log phase SD medium.

559292:YOR163W
gene id: 559292:YOR163W
uniprot id: Q99321
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.
messages: Cytoplasm
messages: May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate).
messages: Nucleus
messages: Present with 3340 molecules/cell in log phase SD medium.

559292:YDR436W
gene id: 559292:YDR436W
uniprot id: P33329
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Essential for the maintenance of cell size and integrity in response to osmotic stress.
messages: Present with 189 molecules/cell in log phase SD medium.

559292:YCR095C
gene id: 559292:YCR095C
uniprot id: P25366
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Exhibits an absence of G1 checkpoint in response to linoleic acid hydroperoxide (LoaOOH) treatment. Rescues the temperature sensitivity of CDC13-1 mutant.
messages: Present with 5370 molecules/cell in log phase SD medium.
messages: Required for replication of Brome mosaic virus (BMV).

559292:YBR137W
gene id: 559292:YBR137W
uniprot id: P38276
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0303 family.
messages: Cytoplasm
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YOR122C
gene id: 559292:YOR122C
uniprot id: P07274
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
messages: cytoskeleton

559292:YDR161W
gene id: 559292:YDR161W
uniprot id: Q03771
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a chaperone for the L4 ribosomal subunit encoded by RPL4A and PRPL4B, required for hierarchical ribosome assembly. Shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.
messages: Belongs to the ACL4 family.
messages: Cytoplasm
messages: Interacts with RPL4A and RPL4B.
messages: Nucleus
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YJR147W
gene id: 559292:YJR147W
uniprot id: P47175
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Cytoplasm
messages: Involved in pseudohyphal differentiation.
messages: Nucleus
messages: Present with 2050 molecules/cell in log phase SD medium.

559292:YGR215W
gene id: 559292:YGR215W
uniprot id: P53305
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion

559292:Q0065
gene id: 559292:Q0065
uniprot id: P03878
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: In the N-terminal section; belongs to the heme-copper respiratory oxidase family.
messages: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break at the junction of the two exons a4-a5 of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-TTTGGTCACCCTGAAGTA-3'. The protein may acquire mRNA maturase activity, like the closely related bI4, through a single amino acid substitution Glu-362 to Lys or when present together with a mutant form of the imported mitochondrial leucyl-tRNA synthetase NAM2.
messages: Mitochondrion
messages: Residues 299 to 556 are sufficient for endonuclease and intron homing activity.
messages: The mature protein may arise from proteolytic cleavage of an in-frame translation of COX1 exons 1 to 4 plus intron 4, containing the aI4 open reading frame. Cleavage would take place close to the Met-299 resulting in an active endonuclease of about 30 kDa.

559292:YOL054W
gene id: 559292:YOL054W
uniprot id: Q12161
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POB3 and SPT16.
messages: Nucleus
messages: Present with 6490 molecules/cell in log phase SD medium.

559292:YDL210W
gene id: 559292:YDL210W
uniprot id: P32837
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid/choline transporter (ACT) (TC 2.A.3.4) family.
messages: In the presence of GABA.
messages: It requires NPR (nitrogen permease reactivator protein) for its full activity.
messages: Required for high-affinity, high-specificity GABA transport. Also transports putrescine.
messages: Vacuole membrane

559292:YOR375C
gene id: 559292:YOR375C
uniprot id: P07262
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the incorporation of an ammonium ion into alpha-ketoglutarate to form L-glutamate, the major route of assimilation of ammonia into an organic form in yeast.
messages: Homohexamer.
messages: Present with 77500 molecules/cell in log phase SD medium.

559292:YDR425W
gene id: 559292:YDR425W
uniprot id: Q04053
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Binds to SNX4.
messages: Endosome
messages: Endosome membrane
messages: Involved in proper sorting of the v-SNARE protein SNC1.
messages: Present with 450 molecules/cell in log phase SD medium.
messages: Prevacuolar compartment
messages: The PX domain binds to phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the punctate structures.

559292:YDL194W
gene id: 559292:YDL194W
uniprot id: P10870
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Glucose-repressible.
messages: High-affinity low glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell (PubMed:8901598, PubMed:9564039). The transporter-like sensor generates an intracellular signal in the presence of low levels of glucose to promote low glucose-induced expression of HXT2 (PubMed:9564039). Binding of glucose to the SNF3 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (By similarity). SNF3 is involved as well in the transport of mannose and fructose (PubMed:20014043). Even though SNF3 is similar to glucose transporters, it appears to be unable to transport glucose (PubMed:9564039).
messages: Phosphorylated in the C-terminal tail on Yck consensus sites in a yeast casein kinases YCK1 and YCK2 (Yck)-dependent manner. This phosphorylation is required for interaction with HXT corepressors MTH1 and STD1 and ultimately HXT expression.
messages: The C-terminal cytoplasmic domain seems to be important for SNF3 regulatory function.

559292:YDL131W
gene id: 559292:YDL131W
uniprot id: Q12122
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
messages: Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.
messages: Mitochondrion
messages: Present with 21900 molecules/cell in log phase SD medium.

559292:YDR398W
gene id: 559292:YDR398W
uniprot id: Q04177
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP5 family.
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
messages: Present with 33100 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR288W
gene id: 559292:YDR288W
uniprot id: Q05541
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6. Interacts with NSE4. Interacts with NSE1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2540 molecules/cell in log phase SD medium.

559292:YPL041C
gene id: 559292:YPL041C
uniprot id: Q03079
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion outer membrane

559292:YML061C
gene id: 559292:YML061C
uniprot id: P07271
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: Cell cycle-regulated. The nuclear isoform is present in very low amounts in G1 phase cells, but increases as cells progress through S phase, with a peak in late S/G2. The mitochondrial isoform follows a similar, but less pronounced induction pattern. The nuclear isoform is prone to APC/C-dependent degradation in G1, whereas the mitochondrial isoform is not.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Appears to move along DNA in single nucleotide or base pair steps, powered by hydrolysis of 1 molecule of ATP. Processes at an unwinding rate of about 75 bp/s. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replication fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.
messages: Mg(2+). To a lesser extent, can also use Mn(2+).
messages: Mitochondrion inner membrane
messages: Monomer in solution. DNA binding induces dimerization. Associates with mitochondrial and telomeric DNA. Binding to mtDNA is non-specific and the protein seems to coat the entire mtDNA molecule. Binds to the telomerase RNA TLC1. Interacts with the mitochondrial single-strand DNA-binding protein RIM1.
messages: Phosphorylated. Undergoes RAD53-dependent phosphorylation in response to loss of mtDNA.
messages: Present with 259 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-40 of isoform Mitochondrial.
messages: nucleolus

559292:YGL013C
gene id: 559292:YGL013C
uniprot id: P12383
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Positive regulator of proteins involved in permeability. PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5.
messages: Present with 1300 molecules/cell in log phase SD medium.
messages: the 9aaTAD motif (residues 1054 to 1062) is a transactivation domain present in a large number of yeast and animal transcription factors.

559292:YLR008C
gene id: 559292:YLR008C
uniprot id: Q07914
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM14 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1).
messages: Homodimer and heterodimer with PAM16/TIM16. Homodimerization may not be relevant in vivo, while heterodimerization is essential for activity regulation of mtHSP70. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18/TIM14. Interacts directly with mtHsp70. Interacts directly with TIM17 subunit of the TIM23 complex.
messages: Mitochondrion inner membrane
messages: The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.

559292:YMR155W
gene id: 559292:YMR155W
uniprot id: Q03795
names: Subcellular Location Annotation
messages: Membrane

559292:YGL058W
gene id: 559292:YGL058W
uniprot id: P06104
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. In association with the E3 enzyme BRE1 and LGE1, it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In association with the E3 enzyme RAD18, it catalyzes the monoubiquitination of POL30 'Lys-164', involved in postreplication repair of UV-damaged DNA. The RAD6/UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. In association with the E3 enzyme UBR1, is involved in N-end rule-dependent protein degradation. Also involved in sporulation.
messages: Cytoplasm
messages: Forms a heterodimer complexes with the E3 enzymes BRE1, RAD18 and UBR1. Interacts also with UBR2, RTF1, PAF1 and the RNA polymerase II hyperphosphorylated form. The interaction with RNA polymerase II is BRE1- and PAF1-dependent.
messages: Nucleus
messages: Present with 2770 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.
messages: The acidic-tail domain of UBC2 mediates interaction with UBR1 and UBR2, and thus is important for polyubiquitination of histones. This domain is also important for sporulation.
messages: Up-regulated by UV radiations and during meiosis.

559292:YMR269W
gene id: 559292:YMR269W
uniprot id: Q03525
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms homooligomers. Associates with ribosomal complexes.
messages: Trans-acting factors of the ribosome biogenesis process.
messages: nucleolus

559292:YER117W
gene id: 559292:YER117W
uniprot id: P0CX41
uniprot id: P0CX42
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Methylated by RKM1 at 2 different sites, but it is unclear which are the 2 methylated residues among Lys-40, Lys-106 and/or Lys-110.
messages: There are 2 genes for uL14 in yeast.

559292:YLR043C
gene id: 559292:YLR043C
uniprot id: P22217
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Mitochondrion intermembrane space
messages: Monomer. Part of the heterodimeric LMA1 complex together with the proteinase inhibitor PBI2. Most of the thioredoxin of yeast is in this complex rather than the well-studied monomer. LMA1 binds to the ATPase SEC18.
messages: Nucleus
messages: Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl-hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism.
messages: Present with 8579 molecules/cell in log phase SD medium.
messages: Reversible disulfide bond formation between Cys-30 and Cys-33, reverted by thioredoxin reductase TRR1 using NADPH as hydrogen donor.
messages: Yeast has two cytoplasmic thioredoxins, TRX1 and TRX2, and one mitochondrial, TRX3.

559292:YDR143C
gene id: 559292:YDR143C
uniprot id: P22470
names: Function
names: Miscellaneous
messages: Plays a specific role in mating-type regulation of yeast, by acting post-translationally to control the stability or activity of the SIR4 proteins.
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YOR167C
gene id: 559292:YOR167C
uniprot id: Q3E7X9
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatB.
messages: Present with 94500 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS28 in yeast.

559292:YOL023W
gene id: 559292:YOL023W
uniprot id: P25038
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Mitochondrion
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
messages: Present with 1400 molecules/cell in log phase SD medium.

559292:YHR201C
gene id: 559292:YHR201C
uniprot id: P38698
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PPase class C family.
messages: Polyphosphatase (polyPase) involved in the degradation of inorganic polyphosphates (polyP) that is able to degrade a range of chains from three to several hundreds of residues in a highly processive manner.
messages: Present with 3170 molecules/cell in log phase SD medium.

559292:YKL027W
gene id: 559292:YKL027W
uniprot id: P36101
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesA/MoeB/ThiF family.
messages: Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
messages: Displays only the t(6)A but not the ct(6)A modification in tRNAs. Unable to sustain respiratory growth under non-fermenting conditions.
messages: Mitochondrion outer membrane
messages: Present with 1170 molecules/cell in log phase SD medium.
messages: ct(6)A is involved in promoting decoding efficiency. It is an unstable modification that can be easily hydrolyzed and converted to t(6)A during nucleoside preparation by conventional methods (PubMed:23242255).

559292:YBR114W
gene id: 559292:YBR114W
uniprot id: P31244
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the global genome repair (GGR) complex composed of at least ABF1, RAD7 and RAD16 (PubMed:10601031). Interacts with ELC1 (PubMed:19920177).
messages: Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Involved in differential repair of DNA after UV damage. Will repair preferentially the MAT-alpha locus compared with the HML-alpha locus.
messages: Nucleus
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YPL090C
gene id: 559292:YPL090C
uniprot id: P0CX37
uniprot id: P0CX38
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS6 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). Interacts with snoRNA U3. uS11 interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).
messages: Cytoplasm
messages: Present with 38800 molecules/cell in log phase SD medium.
messages: Present with 66000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS6 in yeast.
messages: nucleolus

559292:YOR348C
gene id: 559292:YOR348C
uniprot id: P15380
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane
messages: Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as non-specific GABA permease. Can also transport alanine and glycine.
messages: Requires the presence of GABA.

559292:YER101C
gene id: 559292:YER101C
uniprot id: P39945
names: Function
names: Miscellaneous
messages: Lipid raft-associated protein involved in the targeting of PMA1 from Golgi to the plasma membrane (Probable). May induce clustering of PMA1, which facilitates partition of PMA1 into lipid rafts after leaving the ER its and transport to the cell surface (By similarity).
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YDR411C
gene id: 559292:YDR411C
uniprot id: Q12743
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: By endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear and its inability to complement der1 mutations, suggests either that it is not involved in degradation process of misfolded proteins, or that it participates in the destruction of specific misfolded ER luminal proteins.

559292:YGL057C
gene id: 559292:YGL057C
uniprot id: P53171
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GEP7 family.
messages: Involved in respiratory growth and required for cell survival in the absence of prohibitins or GEM1.
messages: Mitochondrion membrane

559292:YGR254W
gene id: 559292:YGR254W
uniprot id: P00924
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.
messages: Present with 76700 molecules/cell in log phase SD medium.

559292:YGR235C
gene id: 559292:YGR235C
uniprot id: P50087
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family. Yeast Mic26 subfamily.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.
messages: Mitochondrion inner membrane
messages: Moderate changes in the mitochondrial morphology.
messages: Present with 5220 molecules/cell in log phase SD medium.

559292:YPL228W
gene id: 559292:YPL228W
uniprot id: O13297
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal TPase family.
messages: First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
messages: Heterodimer (PubMed:6389537, PubMed:3029058). The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase (PubMed:6389537, PubMed:3029058, PubMed:12788946).
messages: Nucleus
messages: Present with 3900 molecules/cell in log phase SD medium.

559292:YDR282C
gene id: 559292:YDR282C
uniprot id: Q05648
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Belongs to the RMD1/sif2 family.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion inner membrane

559292:YCL043C
gene id: 559292:YCL043C
uniprot id: P17967
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Interacts with EPS1, KAR2 and MNL1.
messages: Protein disulfide isomerase of ER lumen required for formation of disulfide bonds in secretory and cell-surface proteins and which unscrambles non-native disulfide bonds. Forms a complex with MNL1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response.
messages: The N-terminus is blocked.

559292:YGL083W
gene id: 559292:YGL083W
uniprot id: P53009
names: Domain
names: Miscellaneous
messages: Present with 1480 molecules/cell in log phase SD medium.
messages: The protein kinase domain is predicted to be catalytically inactive.

559292:YNR045W
gene id: 559292:YNR045W
uniprot id: P07390
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Present with 450 molecules/cell in log phase SD medium.
messages: Required for the expression of the mitochondrial gene for cytochrome c oxidase subunit III (COX3).

559292:YLR162W-A
gene id: 559292:YLR162W-A
uniprot id: Q3E811
names: Function
names: Similarity
messages: Belongs to the ART2/RRT15 family.
messages: Involved in modulation of rDNA transcription.

559292:YDR234W
gene id: 559292:YDR234W
uniprot id: P49367
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
messages: Mitochondrion
messages: Present with 7350 molecules/cell in log phase SD medium.

559292:YIL108W
gene id: 559292:YIL108W
uniprot id: P40483
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10B family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YDR027C
gene id: 559292:YDR027C
uniprot id: Q12071
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS54 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts also with YPT6, TLG1, RBL2, SEC10, SEC15, EXO84 and ARL1.
messages: Endosome membrane
messages: Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. Seems also to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton.
messages: Mitochondrion membrane
messages: Present with 2540 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YLR398C
gene id: 559292:YLR398C
uniprot id: P35207
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Component of the SKI complex composed of at least SKI2, SKI3 and SKI8. The SKI complex interacts with SKI7, which makes the link between the SKI complex and the exosome in order to perform mRNA degradation.
messages: Cytoplasm
messages: Present with 5770 molecules/cell in log phase SD medium.
messages: RNA helicase component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon.

559292:YIL177C
gene id: 559292:YIL177C
uniprot id: P40434
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YJL085W
gene id: 559292:YJL085W
uniprot id: P19658
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO70 family.
messages: Bud
messages: Bud neck
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in the assembly of the exocyst.
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84. Interacts with RHO3.
messages: secretory vesicle

559292:YJL055W
gene id: 559292:YJL055W
uniprot id: P47044
names: Miscellaneous
names: Similarity
messages: Belongs to the LOG family.
messages: Present with 6440 molecules/cell in log phase SD medium.

559292:YKL041W
gene id: 559292:YKL041W
uniprot id: P36095
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment oflate-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III.
messages: Core component of the ESCRT-III complex (endosomal sorting required for transport complex III). ESCRT-III appears to be sequentially assembled as a flat lattice on the endosome membrane and forms a transient 450 kDa complex that contains DID4, oligomerized SNF7, VPS20 and VPS24. SNF7 oligomerization into a membrane-associated filament is nucleated by association of SNF7 with VPS20; the process is terminated through association of VPS24, possibly by capping the SNF7 filament. VPS24 subsequently associates with DID4/VPS2. Interacts with the VPS4. Interacts with DID2.
messages: Endomembrane system
messages: Endosome membrane
messages: Present with 1890 molecules/cell in log phase SD medium.

559292:YMR312W
gene id: 559292:YMR312W
uniprot id: Q04868
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP6 family.
messages: Component of the elongator complex which consists of ELP1/IKI3, ELP2, ELP3, ELP4, ELP5/IKI1 and ELP6 (PubMed:11435442, PubMed:11390369, PubMed:11689709, PubMed:27974378, PubMed:27872205). The elongator complex is composed of two copies of the Elp123 subcomplex (composed of ELP1/IKI3, ELP2 and ELP3) and two copies of the Elp456 subcomplex (composed of ELP4, ELP5/IKI1 and ELP6) (PubMed:27974378, PubMed:27872205). The Elp123 subcomplex forms a two-lobed scaffold, which binds the Elp456 subcomplex asymmetrically (PubMed:27974378, PubMed:27872205). In each lobe, ELP2 is tightly sandwiched between ELP1/IKI3 and ELP3 (PubMed:31309145). The Elp123 subcomplex binds tRNA through ELP1/IKI3 and ELP3 and can bind 2 tRNAs simultaneously (PubMed:31309145). tRNA-binding by the Elp123 subcomplex induces conformational rearrangements which precisely position the targeted anticodon base in the active site (PubMed:31309145). The Elp456 subcomplex binds tRNA and has ATPase activity (PubMed:22556426, PubMed:22343726).
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368).
messages: Cytoplasm
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

559292:YER090W
gene id: 559292:YER090W
uniprot id: P00899
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
messages: Present with 6510 molecules/cell in log phase SD medium.
messages: Tetramer of two components I and two components II.

559292:YIL046W
gene id: 559292:YIL046W
uniprot id: P39014
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
messages: Cytoplasm
messages: Homomultimer (PubMed:14660673). Interacts with CDC53 and SKP1/CBF3D to form the E3 ubiquitin ligase complex SCF(Met30) (PubMed:14660673, PubMed:9499404, PubMed:9716410, PubMed:33443148). Interacts with MET4 (PubMed:10637232, PubMed:15883825, PubMed:8524217).
messages: Nucleus
messages: Present with 217 molecules/cell in log phase SD medium.
messages: Substrate-recognition component of the SCF(Met30) complex, an E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9716410, PubMed:10637232, PubMed:14660673). Negatively regulates sulfur amino acids biosynthesis genes expression (PubMed:8524217, PubMed:15689486, PubMed:15870262). Controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the SCF(Met30) complex (PubMed:8524217, PubMed:15689486, PubMed:15870262). Required for the efficient binding of CDC45 and MCM proteins to origins of replication (PubMed:8524217, PubMed:15689486, PubMed:15870262). Required for efficient expression of G1 cyclins (PubMed:15870262). The SCF(Met30) complex catalyzes ubiquitination and degradation of the Cdk-inhibitory kinase SWE1 (PubMed:9716410). Involved in the S-adenosylmethionine (AdoMet)-mediated inhibition of the transcription function of MET4 (PubMed:8524217, PubMed:10637232). The SCF(Met30) complex mediates ubiquitination and subsequent degradation of MET4 and the cellular response to cadmium (PubMed:10637232). The SCF(Met30) complex acts as an inhibitor of autophagy by promoting ubiquitination and degradation of ATG9 in normal conditions (PubMed:33443148).
messages: Transcriptional activation requires MET4 as well as MET31 and MET32. Regulated by intracellular AdoMet levels. L-methionine regulates the abundance of MET30. The amount of MET30 regulates the activity of the E3 ubiquitin ligase complex SCF(Met30).

559292:YKL004W
gene id: 559292:YKL004W
uniprot id: P36107
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AUR1 family.
messages: Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.
messages: Component of the inositol phosphorylceramide synthase complex composed of at least AUR1 and KEI1.
messages: Golgi stack membrane
messages: Inhibited by aureobasidin A (AbA), khafrefungin and rustmicin.
messages: Present with 4170 molecules/cell in log phase SD medium.

559292:YKL103C
gene id: 559292:YKL103C
uniprot id: P14904
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Binds 2 Zn(2+) ions per subunit. The average amount of Zn(2+) bound at physiological metal concentrations will be lower than stoichiometric.
messages: Homododecamer. The precursor form of aminopeptidase 1 (prApe1) assembles into dodecamers and further aggregates into higher multimers (the Ape1 complex) in the cytoplasm. The Ape1 complex is disaggregated in the vacuolar lumen, but mature aminopeptidase 1 (mApe1) retains its dodecameric form. Dodecamer assembly in the cytoplasm is essential for formation of an enzymatically active complex. If cytoplasmic homododecamerization of prApe1 is disturbed in mutants, homododecamers of mApe1 will form in the vacuole, but they are enzymatically inactive. Interacts with ATG19.
messages: It is unsure whether this protein is glycosylated or not. PubMed:5147 has shown that a preparation of aminopeptidase 1 contains about 12% of conjugated carbohydrate, while PubMed:1400574 could not identify any glycosylation, which is in agreement with the fact that aminopeptidase 1 does not transit through the secretory pathway.
messages: Present with 5730 molecules/cell in log phase SD medium.
messages: Resident vacuolar enzyme that catalyzes the removal of amino acids from the N-terminus of peptides and proteins. Also acts as the major cargo protein of the cytoplasm-to-vacuole targeting (Cvt) pathway. The precursor form of aminopeptidase 1 (prApe1) assembles into dodecamers and the propeptide mediates the aggregation of dodecamers into higher multimers. The multimers are then recognized via the propeptide by their receptor ATG19, and ATG19 further interacts with ATG11, which tethers the APE1-ATG19 complex to the pre-autophagosomal structure (PAS). The cargo-receptor complex (also Cvt complex) is selectively enwrapped by a double-membrane structure termed the Cvt vesicle under vegetative growth conditions and by a similar but larger double-membrane structure termed the autophagosome under nitrogen starvation conditions. The Cvt vesicle or the autophagosome fuses with the vacuolar membrane and release its content in the vacuolar lumen. In the vacuole, prApe1 is processed into mature aminopeptidase 1 (mApe1).
messages: Strongly and specifically activated by Cl(-) and Br(-), which act as positive allosteric effectors. Inactivated by metal-chelating agents.
messages: Synthesized in a precursor form (prApe1) that has an amino-terminal propeptide. The N-terminal extension of the 61 kDa precursor is proteolytically processed in two sequential steps. The first step involves proteinase A (PrA/PEP4) and produces a 55 kDa unstable intermediate (iAPI). The second step involves proteinase B (PrB/PRB1) and converts iAPI into the 50 kDa stable, mature enzyme (mApe1).
messages: Vacuole

559292:YOL135C
gene id: 559292:YOL135C
uniprot id: Q08278
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. MED7 interacts directly with MED1, MED4 and SRB7/MED21.
messages: Nucleus
messages: Present with 7598 molecules/cell in log phase SD medium.

559292:YKL183C-A
gene id: 559292:YKL183C-A
uniprot id: Q3E765
names: Subcellular Location Annotation
messages: Membrane

559292:YBR080C
gene id: 559292:YBR080C
uniprot id: P18759
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Homohexamer. Binds to SEC17.
messages: Present with 5920 molecules/cell in log phase SD medium.
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

559292:YDR043C
gene id: 559292:YDR043C
uniprot id: Q03125
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 556 molecules/cell in log phase SD medium.
messages: Transcriptional repressor involved in regulation of glucose repression. Binds to UAS-1 in the STA1 promoter.

559292:YML068W
gene id: 559292:YML068W
uniprot id: Q04638
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RBR family.
messages: Interacts with translation release factors eRF1 (SUP45) and eRF3 (SUP35) in vitro.
messages: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA.
messages: Present with 846 molecules/cell in log phase SD medium.

559292:YFR003C
gene id: 559292:YFR003C
uniprot id: P43587
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YPI1 family.
messages: Interacts with GLC7, PPZ1 and SDS22.
messages: Nucleus
messages: Present with 1080 molecules/cell in log phase SD medium.
messages: Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control. Regulates the nuclear localization of type 1 phosphatase GLC7 and SDS22, and is involved in the regulation of mRNA 3'-end processing. May also regulate the activity of type 1 phosphatase PPZ1.
messages: Was originally (PubMed:14506263) thought to be an inhibitor of type 1 phosphatases using in vitro experiments, but further in vivo experiments (PubMed:18172024) showed that it was rather an activator of these phosphatases.

559292:YBL049W
gene id: 559292:YBL049W
uniprot id: P38191
names: Similarity
messages: Belongs to the yippee family.

559292:YPL153C
gene id: 559292:YPL153C
uniprot id: P22216
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
messages: Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.
messages: FHA domains are phosphothreonine recognition modules, FHA 1 strongly selects for Asp at position +3 relative to phosphothreonine, whereas FHA 2 selects for Ile in this position.
messages: Interacts with PIN4.
messages: Nucleus
messages: Present with 6900 molecules/cell in log phase SD medium.

559292:YBR172C
gene id: 559292:YBR172C
uniprot id: P32909
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMY2/mpd2 family.
messages: Cytoplasm
messages: Interacts with EAP1 and MSL5 (via the GYP domain).
messages: Present with 486 molecules/cell in log phase SD medium.
messages: Suppressor of the MYO2 gene.

559292:YPL131W
gene id: 559292:YPL131W
uniprot id: P26321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). uL18 forms a heterotrimeric complex with SYO1 and uL5 (RPL11A/RPL11B). Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer (PubMed:23118189).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus

559292:YOR038C
gene id: 559292:YOR038C
uniprot id: P32480
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes localization of RTT106 to the HTA1-HTB1 promoter.
messages: Belongs to the WD repeat HIR1 family.
messages: Chromosome
messages: Component of the HIR complex, composed of HIR1, HIR2, HIR3 and HPC2 (PubMed:16264190, PubMed:16303565, PubMed:9001207). This complex may consist of one copy of HIR1 and HIR3 and two copies of HIR2 and HPC2 (PubMed:16264190). The HIR complex interacts with ASF1 (PubMed:11412995, PubMed:16303565). Interacts with SNF2 (PubMed:10445029). Interacts with SNF5 (PubMed:10445029). Interacts with SWI3 (PubMed:10445029). Interacts with RTT106 (PubMed:19683497).
messages: Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during the cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
messages: Nucleus
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YDR513W
gene id: 559292:YDR513W
uniprot id: P17695
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutaredoxin family.
messages: Component of the glutathione system which performs several activities such as glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity (PubMed:11875065, PubMed:12684511). The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. GRX2 is more active as an oxidoreductase than GRX1 (PubMed:9571241, PubMed:18992757, PubMed:20417731). Responsible for the S-glutathionylation of DHBP synthase (PubMed:21565288).
messages: Cytoplasm
messages: In response to exposure to reactive oxygen species (ROS) and upon entry into stationary phase.
messages: It is unclear whether the long polypeptide observed in mitochondria represents the immature form of the protein before cleavage of the transit peptide and release of the short form into the cytoplasm or whether two mature isoforms exists.
messages: Mitochondrion
messages: Present with 31400 molecules/cell in log phase SD medium.

559292:YBL089W
gene id: 559292:YBL089W
uniprot id: P38176
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Probable amino acid transporter of unknown specificity.
messages: Vacuole membrane

559292:YHR038W
gene id: 559292:YHR038W
uniprot id: P38771
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Mitochondrion
messages: Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.
messages: Present with 1440 molecules/cell in log phase SD medium.

559292:YDR494W
gene id: 559292:YDR494W
uniprot id: Q03430
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS46 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion

559292:YOR303W
gene id: 559292:YOR303W
uniprot id: P07258
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Cytoplasm
messages: In eukaryotes this enzyme is synthesized by two pathway-specific (arginine and pyrimidine) under separate control.
messages: Present with 2580 molecules/cell in log phase SD medium.

559292:YER007C-A
gene id: 559292:YER007C-A
uniprot id: P89886
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMA20 family.
messages: Cytoplasm
messages: Interacts with TMA22. Associates with ribosomal complexes.
messages: Involved in translation.
messages: Present with 4220 molecules/cell in log phase SD medium.

559292:YDR181C
gene id: 559292:YDR181C
uniprot id: Q04003
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing. In the complex, SAS4 is essential for histone acetyltransferase (HAT) activity of the complex.
messages: Heterochromatin spreading downstream of the silent mating-type locus HMR.
messages: Interacts with ASF1. Component of the SAS complex, at least composed of SAS2, SAS4 and SAS5. These three proteins constitute the core of the complex and are sufficient to acetylate histones.
messages: Nucleus
messages: Present with 800 molecules/cell in log phase SD medium.

559292:YKL037W
gene id: 559292:YKL037W
uniprot id: P32858
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Increases frequency of mitochondrial genome loss.
messages: Involved in selective mitochondria autophagy (mitophagy).
messages: Mitochondrion membrane

559292:YML065W
gene id: 559292:YML065W
uniprot id: P54784
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with MCM10 and TAH11.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
messages: Nucleus
messages: Present with 3930 molecules/cell in log phase SD medium.
messages: The N-terminus is dedicated to mating-type repression.

559292:YNL047C
gene id: 559292:YNL047C
uniprot id: P53955
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Heterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5-bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2.
messages: Present with 2610 molecules/cell in log phase SD medium.
messages: Together with SLM1, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin, inhibiting interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.

559292:YMR018W
gene id: 559292:YMR018W
uniprot id: Q04364
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Expression is induced by oleate.
messages: Interacts the PTS1-receptor docking protein PEX14 (PubMed:27678487). Interacts with malate synthases MLSL1 and MLS2 (PubMed:27678487). Interacts with TLG1 (PubMed:11283351).
messages: Leads to a clear mislocalization of both MLS1 and MLS2 to the cytosol.
messages: Peroxisomal import receptor that mediates the peroxisomal import of both malate synthases MLS1 and MLS2 in oleate-grown cells (PubMed:27678487, PubMed:27663510). Recognizes the C-terminal peroxisomal targeting signal PTS1 sequence SKL of MLS1 and MLS2, probably via its TPR domains (PubMed:27678487). Interacts with the PTS1-receptor docking protein PEX14 but not with peroxins PEX1, PEX3 through to PEX8, PEX10, PEX11, PEX12, PEX13, PEX15, PEX17, PEX18, PEX19 and PEX21 (PubMed:27678487).
messages: Peroxisome membrane
messages: The TPR repeats are involved in the interaction with the C-terminal peroxisomal targeting signal PTS1 of MLS1 and MLS2.
messages: The WxxxF motif is involved in the interaction with the PTS1-receptor docking protein PEX14.

559292:YIL103W
gene id: 559292:YIL103W
uniprot id: P40487
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323). In association with DPH2, transfers a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:15485916, PubMed:31463593, PubMed:34154323, PubMed:24422557, PubMed:27694803).
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:15485916, PubMed:18627462, PubMed:23645155, PubMed:24422557, PubMed:27694803, PubMed:31463593). Interacts with DPH2; the interaction is direct (PubMed:15485916, PubMed:23645155, PubMed:31463593). Interacts with KTI11/DPH3 (PubMed:12940988, PubMed:18627462, PubMed:23645155, PubMed:27694803).
messages: Cytoplasm
messages: Increases translational -1 frameshifting (PubMed:18627462). Abolishes the formation of the 2-(3-amino-3-carboxypropyl)histidine synthase complex (PubMed:18627462). Resistance to sordarin and zymocin (PubMed:18627462).
messages: Present with 2526 molecules/cell in log phase SD medium.

559292:YGL226C-A
gene id: 559292:YGL226C-A
uniprot id: Q92316
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:8175708, PubMed:16297388, PubMed:16096345, PubMed:15886282, PubMed:9405463, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962).
messages: Endoplasmic reticulum membrane
messages: Present with 1010 molecules/cell in log phase SD medium.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

559292:YAR035W
gene id: 559292:YAR035W
uniprot id: P80235
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: By ethanol and by acetate. Repressed by glucose, and to a lesser extent, by galactose. Derepressed by glycerol.
messages: Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol.
messages: Mitochondrion inner membrane

559292:YBL007C
gene id: 559292:YBL007C
uniprot id: P32790
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLA1 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
messages: Component of the PAN1 actin cytoskeleton-regulatory complex. Interacts with ABP1, KRE6, LAS17, LSB5, RSP5, RVS167, VPS1 and YSC84.
messages: Endosome membrane
messages: Nucleus
messages: Phosphorylated by PRK1.
messages: Present with 952 molecules/cell in log phase SD medium.
messages: actin patch

559292:YJL223C
gene id: 559292:YJL223C
uniprot id: P0CE88
uniprot id: P0CE89
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YGL175C
gene id: 559292:YGL175C
uniprot id: P46946
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Cytoplasm
messages: Dimer or multimer. Interacts with MRE11.
messages: Endonuclease that cooperates with the MRX complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of SPO11 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for proper recovery from checkpoint-mediated cell cycle arrest after DNA damage. MRX complex and SAE2 remove a small oligonucleotide(s) from the DNA ends to form an early intermediate which is rapidly processed by EXO1 and/or SGS1 to generate extensive tracts of single-stranded DNA that serve as substrate for RAD51. Plays a transitional role in the dissociation of MRE11 from, and the recruitment of RAD52 to, repair foci. Ensures that both ends of a DSB participate in a recombination event and impairs the formation of palindromic structures in the genome. With TEL1, promotes microhomology-mediated end joining (MMEJ) but inhibits non-homologous end joining (NHEJ), likely by regulating MRE11-dependent ssDNA accumulation at DNA break. SAE2 and MRX are particularly important for removal of hairpins, bulky adducts and other irregular end structures. Facilitates telomere length reequilibration and subsequent checkpoint switch off. Involved in homing efficiency of VMA1 intein VDE and in repair of transposon excision sites.
messages: Nucleus
messages: Phosphorylated forms accumulate periodically during the unperturbed cell cycle and in response to DNA damage in G2. Phosphorylated by MEC1 and TEL1. Mutagenesis experiments showed that several of the 5 residues located in canonical (S/T)Q motifs, which are favored for phosphorylation by ATM/ATR kinases (Ser-73, Thr-90, Ser-249, Thr-279 and Ser-289) may be phosphorylated. Phosphorylated at Ser-267 by CDC28 which is required to initiate meiotic DSB resection by allowing SPO11 removal from DSB ends.
messages: Present with 1030 molecules/cell in log phase SD medium.

559292:YDR287W
gene id: 559292:YDR287W
uniprot id: Q05533
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Inhibited by Li(+) and Na(+).
messages: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling.

559292:YDL133W
gene id: 559292:YDL133W
uniprot id: Q12516
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: During S phase of cell cycle.
messages: Interacts with SPO14.
messages: Membrane
messages: Regulator of phospholipase D (SPO14) which is required for SPO14 catalytic activity in mitotic cells. Essential to buffer the toxic effects of C16:0 platelet activating factor.

559292:YHR099W
gene id: 559292:YHR099W
uniprot id: P38811
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, suggesting that it may lack such activity.
messages: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7,TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9. Also identified in the NuA4 complex with ESA1. Identified in the Ada.spt complex with ADA3 and SPT7.
messages: Essential component of histone acetyltransferase (HAT) complexes, which serves as a target for activators during recruitment of HAT complexes. Essential for vegetative growth. Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
messages: Nucleus
messages: The C-terminal domain (2233-2836) is essential for its ability to interact with activators.

559292:YDL089W
gene id: 559292:YDL089W
uniprot id: Q12066
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NUR1 family.
messages: Interacts with CSM1.
messages: Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.
messages: Nucleus membrane
messages: Present with 606 molecules/cell in log phase SD medium.

559292:YDR545W
gene id: 559292:YDR545W
uniprot id: P0CX20
uniprot id: P0CX21
uniprot id: P0CX22
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YDR481C
gene id: 559292:YDR481C
uniprot id: P11491
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cytoplasm
messages: Phosphatase with broad substrate specificity. A truncated (soluble) version of the protein is responsible for the production of (E,E)-farnesol from (E,E)-farnesyl diphosphate. Acts as a fructose-2,6-bisphosphate 6-phosphatase (PubMed:1848184).
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YBR010W
gene id: 559292:YBR010W
uniprot id: P61830
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5, a component of the SAGA complex, is promoted by H3S10ph. Further acetylated by GCN5 to form H3K9ac, H3K18ac, H3K23ac, H3K27ac and H3K36ac. H3K14ac can also be formed by ESA1, a component of the NuA4 histone acetyltransferase (HAT) complex. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP, UAF seems to stimulate basal transcription to a fully activated level.
messages: Crotonylation (Kcr) marks active promoters and enhancers and confers resistance to transcriptional repressors.
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1.
messages: Nucleus
messages: Phosphorylated by IPL1 to form H3S10ph in a cell cycle-dependent manner during mitosis and meiosis. H3S10ph is also formed by SNF1, promotes subsequent H3K14ac formation by GCN5, and is required for transcriptional activation through TBP recruitment to the promoters. Dephosphorylation is performed by GLC7.
messages: Present with 213000 molecules/cell in log phase SD medium.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Histone H3 is a component of the UAF (upstream activation factor) complex, which consists of UAF30, RRN5, RRN9, RRN10, and histones H3 and H4.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

559292:YER162C
gene id: 559292:YER162C
uniprot id: P14736
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Cytoplasm
messages: Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
messages: Nucleus
messages: Present with 876 molecules/cell in log phase SD medium.

559292:YCR079W
gene id: 559292:YCR079W
uniprot id: P25646
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Confers rapamycin-sensitivity.
messages: Interacts with PRO2.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Present with 432 molecules/cell in log phase SD medium.
messages: Protein phosphatase that shows typical type 2C protein phosphatase (PP2C) activity (PubMed:17002782). Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex (PubMed:18180296). Required for efficient mitophagy in stationary phase cells (PubMed:17166847).

559292:YPL117C
gene id: 559292:YPL117C
uniprot id: P15496
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 3,4-epoxy-l-butenyl diphosphate and 3-(fluoromethyl)-3-butenyl diphosphate (FIPP) act as specific active site-directed inhibitors of IP Pisomerase.
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Isopentenyl-diphosphate delta-isomerase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:2223785, PubMed:2681212, PubMed:7908830). IDI1 catalyzes the 1,3-allylic rearrangement of isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (PubMed:2223785, PubMed:2681212, PubMed:7908830). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672).
messages: Present with 25500 molecules/cell in log phase SD medium.

559292:YPR052C
gene id: 559292:YPR052C
uniprot id: P11632
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NHP6 family.
messages: Chromosome
messages: DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6B.
messages: Nucleus
messages: Present with 3870 molecules/cell in log phase SD medium.
messages: Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT (yFACT or SNP) complex, which is associated with nucleosomes. Multiple molecules of NHP6 (NHP6A and/or NHP6B) are required to recruit the SPT16-POB3 heterodimer to DNA.

559292:YHR004C
gene id: 559292:YHR004C
uniprot id: P38757
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dullard family.
messages: Catalytic component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates the phosphatidic acid phosphohydrolase PAH1 (PubMed:15889145). Essential for the formation of a spherical nucleus and meiotic division (PubMed:9822591). The NEM1-SPOo7 protein phosphatase is required for efficient mitophagy under prolonged respiration, as well as for reticulophagy and pexophagy (PubMed:29305265).
messages: Component of the NEM1-SPO7 complex.
messages: Endoplasmic reticulum membrane
messages: Leads to inefficient mitochondrial sequestration and degradation, as well as to defective reticulophagy and pexophagy (PubMed:29305265).
messages: Nucleus membrane
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YBR270C
gene id: 559292:YBR270C
uniprot id: P38346
names: Subunit
messages: Interacts with the target of rapamycin complex 2 (TORC2) subunit TSC11 and the TORC2 effectors SLM1 and SLM2.

559292:YDL164C
gene id: 559292:YDL164C
uniprot id: P04819
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Cdc9 is included within the category of so-called 'start genes', encoding proteins which are required in early G1, when the cell is faced with the option of initiating a further cell cycle.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. The mitochondrial form is required for mitochondrial DNA maintenance but is non-essential while the nuclear form is essential for cell viability.
messages: Mitochondrion
messages: Nucleus
messages: Present with 149 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-24 of isoform Mitochondrial.

559292:YDR325W
gene id: 559292:YDR325W
uniprot id: Q06680
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome
messages: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1920 molecules/cell in log phase SD medium.
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.

559292:YFR046C
gene id: 559292:YFR046C
uniprot id: P43618
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-T/CNN1 family.
messages: Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:14633972, PubMed:22561346). Interacts with outer kinetochore MIND complex subunit NNF1 (PubMed:14633972). Interacts with outer kinetochore Ndc80 complex subunits SPC24 and SPC25 (PubMed:22561346, PubMed:23334295).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:22561346). CNN1 is important for the recruitment of the outer kinetochore Ndc80 complex (PubMed:23334295).
messages: Nucleus
messages: Phosphorylation of the C-ter by MPS1 kinase regulates interaction with the outer kinetochore Ndc80 complex.
messages: Present with 1300 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YBL045C
gene id: 559292:YBL045C
uniprot id: P07256
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). COR1 interacts with COX5A at the CIII-CIV interface (PubMed:30598556, PubMed:30598554).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Does not seem to have protease activity as it lacks the zinc-binding site.
messages: Mitochondrion inner membrane
messages: Present with 19300 molecules/cell in log phase SD medium.

559292:YKL006C-A
gene id: 559292:YKL006C-A
uniprot id: P43682
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a SNARE complex consisting of SED5, GOS1, YKT6 and SFT1.
messages: Golgi apparatus membrane
messages: Multicopy suppressor of sed5-1.
messages: Vesicle SNARE required for retrograde transport within the Golgi complex.

559292:YPL049C
gene id: 559292:YPL049C
uniprot id: Q03063
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: DIG1 and DIG2 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein-protein interaction. DIG1 colocalizes to promoters with STE12 and redistributes with it during induction of filamentation (by butanol) or mating (by pheromone) to program specific genes, but binding of DIG1 to STE12 is reduced by pheromone treatment.
messages: Forms a complex with DIG2, STE12 and either FUS3 or KSS1. The interaction of FUS3 with STE12 depends on the presence of both DIG1 and DIG2. STE12 is lost from FUS3/DIG1/DIG2 complex after pheromone treatment. DIG1 and DIG2 have also been reported to interact with CLN1 and CLN2.
messages: Nucleus
messages: Phosphorylated by FUS3 and KSS1, in a pheromone-stimulated manner. Phosphorylation reduces the affinity for STE12.
messages: Present with 5000 molecules/cell in log phase SD medium (5480 according to TAP-tag study).

559292:YKR067W
gene id: 559292:YKR067W
uniprot id: P36148
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Dual substrate-specific glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase, catalyzing the first and committed reaction in the de novo synthesis of glycerophospholipids and triacylglycerols (TAGs). Can use both Gly-3-P and dihydroxyacetone phosphate with similar efficiencies and has a broad fatty acyl-CoA specificity profile. Transfers a fatty acid from fatty acyl-CoA to the sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid (LysoPA). These lipids not only are precursors of glycerolipids, but also are dynamic components of signal transduction systems that control cell physiology.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Phosphorylatied at a conserved motif involving Ser-664, Ser-668 and Ser-671. This phosphorylation plays a critical role for efficient TAG mobilization. Phosphorylation deficiency at this motif increases the enzyme activity and consequently induces de novo formation of phosphatidic acid.
messages: Present with 3100 molecules/cell in log phase SD medium.

559292:YIR015W
gene id: 559292:YIR015W
uniprot id: P40571
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of nuclear RNase P. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2, many of which are shared with the RNase MPR complex.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: Nucleus
messages: Present with 2070 molecules/cell in log phase SD medium.

559292:YBL104C
gene id: 559292:YBL104C
uniprot id: P38164
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat mio family.
messages: Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.
messages: Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.
messages: Cytoplasm
messages: Present with 184 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YDR197W
gene id: 559292:YDR197W
uniprot id: P14905
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Present with 2140 molecules/cell in log phase SD medium.
messages: Translational activator of cytochrome b. The cytochrome b (coB) leader RNA may represent the target sequence for CBS1 and/ or CBS2.

559292:YER039C
gene id: 559292:YER039C
uniprot id: P0CE11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
messages: This is a truncated version of GDP-mannose transporter 2. Strain S288c has a stop codon in position 73, which disrupts the gene coding for this protein and produces two ORFs YER039C-A and YER039C. A contiguous sequence for GDP-mannose transporter 2 can be found in strain Lalvin EC1118 (AC C8Z742).

559292:YMR252C
gene id: 559292:YMR252C
uniprot id: Q04814
names: Miscellaneous
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YMR077C
gene id: 559292:YMR077C
uniprot id: Q04272
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Required for the oligomerization of SNF7 into a membrane-associated filament. The VPS20-SNF7 subcomplex is responsible for the membrane association of the ESCRT-III complex. Also required for the RIM101 repressor proteolytic activation.
messages: Core component of the ESCRT-III complex (endosomal sorting required for transport complex III). ESCRT-III appears to be sequentially assembled as a flat lattice on the endosome membrane and forms a transient 450 kDa complex that contains DID4, oligomerized SNF7, VPS20 and VPS24. SNF7 oligomerization into a membrane-associated filament is nucleated by association of SNF7 with VPS20; the process is terminated through association of VPS24, possibly by capping the SNF7 filament. VPS24 subsequently associates with DID4/VPS2. Interacts with the VPS4. Interacts with VPS25; the interaction mediates the association with the ESCRT-II complex.
messages: Endosome membrane
messages: Present with 937 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YDR129C
gene id: 559292:YDR129C
uniprot id: P32599
names: Function
names: Miscellaneous
messages: Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity.
messages: Present with 3510 molecules/cell in log phase SD medium.

559292:YGL172W
gene id: 559292:YGL172W
uniprot id: Q02199
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin GLFG family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP49 is part of the NUP57 subcomplex (NIC96, NSP1, NUP49, NUP57) interacting with NUP57. Interacts through its FG repeats with karyopherins.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP49 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.
messages: Nucleus membrane
messages: Present with 4760 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YER158C
gene id: 559292:YER158C
uniprot id: P40095
names: Miscellaneous
names: PTM
names: Similarity
messages: N-glycosylated.
messages: Present with 784 molecules/cell in log phase SD medium.
messages: To yeast AFR1.

559292:YNL056W
gene id: 559292:YNL056W
uniprot id: P53949
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cytoplasm
messages: Present with 4530 molecules/cell in log phase SD medium.
messages: Required for normal growth in the presence of linoleic acid hydroperoxide (LoaOOH).

559292:YHL011C
gene id: 559292:YHL011C
uniprot id: P38689
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Cells fail to arrest in G1, cells remain budded and a significant fraction has a G2 DNA content. In such conditions, deletion mutants have a disorganized actin cytoskeleton and actin accumulates in one or two intensely staining clumps per cell. Deletion mutants also show defects in ion homeostasis and cell integrity. They fail to grow on medium containing 1.0 M NaCl, 5 mM caffeine or when incubated at 37 degrees Celsius. The caffeine and temperature sensitivity are rescued by supplementing the growth medium with 1.0 M sorbitol.
messages: Cytoplasm

559292:YJR074W
gene id: 559292:YJR074W
uniprot id: P47123
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOG1 family.
messages: Interacts with GSP1.
messages: Involved in the Ran-GTPase system for nuclear protein import and poly(A)+ mRNA export.
messages: Nucleus
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YML024W
gene id: 559292:YML024W
uniprot id: P02407
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 30900 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS17 in yeast.

559292:YPR199C
gene id: 559292:YPR199C
uniprot id: Q06596
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. YAP subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Leads to hypersensitivity to arsenic (PubMed:9234670). Impairs the arsenic-dependent induction of arsenate reductase ARR2, arsenite transporter ARR3 and vacuolar transporter YCF1 (PubMed:11527213, PubMed:15147884).
messages: Nucleus
messages: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
messages: Phosphorylation by HOG1 promotes nuclear localization in the presence of arsenic.
messages: Transcription activator required for resistance to arsenic compounds and for a regulated expression of ACR2, ACR3 and YCF1.
messages: Transcriptional activity is controled by regulated degradation by the ubiquitin-proteasome pathway in absence of arsenic (PubMed:17200139). Arsenic-exposure results in stabilization and increased transcriptional activity (PubMed:15147884, PubMed:17200139).

559292:YEL041W
gene id: 559292:YEL041W
uniprot id: P32622
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: ATP-NADH kinase with a low phosphorylation activity of both NADH and NAD(+) to produce NADP and NADPH by using ATP. UTR1 is responsible for essentially all of the NAD/NADH kinase activity resident in the cytoplasm, whereas POS5 is responsible for all mitochondrial NAD/NADH kinase activity and consequent mitochondrial genome maintenance. YEF1 can substitute for UTR1 when overexpressed.
messages: Belongs to the NAD kinase family.
messages: Homooctamer.
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YBR111C
gene id: 559292:YBR111C
uniprot id: Q01976
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the Nudix hydrolase family. NudF subfamily.
messages: Binds 3 Mg(2+) ions per subunit. Can also accept Mn(2+) ions.
messages: Present with 7330 molecules/cell in log phase SD medium.

559292:YIR038C
gene id: 559292:YIR038C
uniprot id: P40582
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer.

559292:YBR248C
gene id: 559292:YBR248C
uniprot id: P33734
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: By amino acid starvation. It has a GCN4-dependent and a GCN4-independent (basal) expression.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
messages: In the C-terminal section; belongs to the HisA/HisF family.
messages: Monomer.
messages: Present with 11800 molecules/cell in log phase SD medium.

559292:YLR312C
gene id: 559292:YLR312C
uniprot id: Q06159
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a receptor for reticulophagy and nucleophagy. Directs autophagic sequestration of double-membrane vesicles derived from the nuclear envelope and perinuclear endoplasmic reticulum (pnER) into autophagosomes. Is not required for the cytoplasm-to-vacuole targeting pathway, mitophagy, pexophagy, and non-selective autophagy.
messages: Endoplasmic reticulum membrane
messages: Expression is increased by rapamycin, which mimics nitrogen starvation by inactivating the TORC1 complex.
messages: Interacts with ATG8 and ATG11.
messages: Partially blocks reticulophagy, and the double ATG39/ATG40 knockout almost completely blocks this pathway. Leads to abnormal morphology in the nucleus/pnER, when exposed to prolonged nitrogen starvation.
messages: Preautophagosomal structure membrane

559292:YEL058W
gene id: 559292:YEL058W
uniprot id: P38628
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins (PubMed:8174553). Also has phosphoglucomutase activity (PubMed:8119301).
messages: Cytoplasm
messages: Nucleus
messages: Present with 14700 molecules/cell in log phase SD medium.
messages: Results in undivided strings of cells and growth arrest after approximately 5 division cycles.

559292:YKL038W
gene id: 559292:YKL038W
uniprot id: P32862
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDS1/RGT1 family.
messages: Cytoplasm
messages: Glucose-induced phosphorylation regulates the DNA-binding activity. Hyperphosphorylation in cells growing on high levels of glucose does prevents DNA-binding and dephosphorylation restores DNA-binding ability.
messages: Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription. Binds the consensus binding site sequence 5'-CGGANNA-3', of which multiple copies are present in all HXT promoters regulated by RGT1.
messages: Nucleus
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YER150W
gene id: 559292:YER150W
uniprot id: P40092
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SED1 family.
messages: Cell wall protein that plays a role in adaptation and resistance to cell wall stress.
messages: Induced by transcription factors MSN2 and MSN4 in stationary phase and by transcription factors MSN2, MSN4 and HAA1 upon weak-acid stress. Up-regulated by low pH.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YBR208C
gene id: 559292:YBR208C
uniprot id: P32528
names: Function
names: Induction
names: Miscellaneous
names: Subunit
messages: By allophanate or its non-metabolized analog oxalurate. Repressed in the presence of readily used nitrogen sources.
messages: Hydrolysis of urea to ammonia and CO(2).
messages: Monomer.
messages: Present with 952 molecules/cell in log phase SD medium.

559292:YBL067C
gene id: 559292:YBL067C
uniprot id: P38187
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Present with 125 molecules/cell in log phase SD medium.

559292:YPL071C
gene id: 559292:YPL071C
uniprot id: Q02864
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

559292:YBR287W
gene id: 559292:YBR287W
uniprot id: P38355
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Membrane
messages: Present with 6440 molecules/cell in log phase SD medium.

559292:YNR006W
gene id: 559292:YNR006W
uniprot id: P40343
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS27 family.
messages: Both IUM domains are necessary for efficient binding to ubiquitin.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27 (PubMed:12055639, PubMed:14581452, PubMed:15086794). Interacts with ENT3 and ENT5, the ESCRT-I subunits VPS23 and VPS28 and with the COPIb subunits SEC27, SEC28 and SEC33 (PubMed:12900393, PubMed:15107463, PubMed:17101773). May form a complex composed of VPS27, HSE1 and DOA1 (PubMed:18508771). Interacts with DOA1 (PubMed:18508771). Interacts with ubiquitin (PubMed:11988742, PubMed:12750381, PubMed:14581452).
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane (PubMed:3062374, PubMed:1493335, PubMed:9265642, PubMed:11416128, PubMed:12055639, PubMed:11872141, PubMed:12900393, PubMed:14581452, PubMed:15166140, PubMed:15107463, PubMed:15086794, PubMed:17135292, PubMed:18508771). Controls exit from the prevacuolar compartment (PVC) in both the forward direction to the vacuole and the return to the Golgi (PubMed:11208109, PubMed:8649377, PubMed:9015300). Allows VPS10 to return to the (trans-Golgi network) TGN from the PVC (PubMed:8649377). Might also function as an alternate adapter in the COPIb clathrin-like coat (PubMed:17101773).
messages: Endosome membrane
messages: Present with 172 molecules/cell in log phase SD medium.
messages: The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes.

559292:YJL088W
gene id: 559292:YJL088W
uniprot id: P05150
names: Activity Regulation
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Forms a stable complex with CAR1 in the presence of ornithine and arginine. In this complex CAR1 retains activity, but ARG3 activity is inhibited.
messages: Interacts with CAR1.
messages: Present with 1140 molecules/cell in log phase SD medium.

559292:YPL183C
gene id: 559292:YPL183C
uniprot id: Q08924
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR6 family.
messages: Cytoplasm
messages: Endosome
messages: Increases Ty1 mobility 31-fold.
messages: Interacts with RRT2. Interacts with TRM7; for 2'-O-methylation of position 34 in substrate tRNAs.
messages: Involved in regulation of Ty1 transposition. Also plays a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Required together with TRM7 for the methylation of the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)).
messages: Present with 3450 molecules/cell in log phase SD medium.

559292:YFL042C
gene id: 559292:YFL042C
uniprot id: P43560
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in sterol transfer between intracellular membranes.
messages: The VASt domain bind sterols.

559292:YDR397C
gene id: 559292:YDR397C
uniprot id: Q92317
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NC2 (negative cofactor 2) complex composed of BUR6 and NCB2. The NC2 complex associates with SPT15/TBP. Interacts with SPT15/TBP.
messages: Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP.
messages: Nucleus
messages: Present with 2950 molecules/cell in log phase SD medium.

559292:YNL208W
gene id: 559292:YNL208W
uniprot id: P40159
names: Subcellular Location Annotation
messages: Mitochondrion

559292:YLR098C
gene id: 559292:YLR098C
uniprot id: P43634
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Activates the CHA1 gene for L-serine dehydratase. Binds to the DNA sequence 5'-GVGGARAYRTRATTCCRC-3'.
messages: Nucleus
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YNL215W
gene id: 559292:YNL215W
uniprot id: P40154
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IES2 family.
messages: Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.
messages: Nucleus
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YPL032C
gene id: 559292:YPL032C
uniprot id: Q03088
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAM1/SVL3 family.
messages: Bud
messages: Bud neck
messages: Cytoplasm
messages: May have a vacuolar function.
messages: Present with 2180 molecules/cell in log phase SD medium.
messages: cell cortex

559292:YIL031W
gene id: 559292:YIL031W
uniprot id: P40537
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C48 family.
messages: Insertion mutation in SMT4 confers temperature and benomyl sensitivity; high copy suppressor of a temperature sensitive mutation in MIF2.
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YOL138C
gene id: 559292:YOL138C
uniprot id: Q08281
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RTC1 family.
messages: Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1. Interacts with ribosomes.
messages: Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in a process influencing telomere capping.
messages: Leads to short telomeres.
messages: Present with 606 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YFL041W
gene id: 559292:YFL041W
uniprot id: P43561
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Binds 4 Cu cations per monomer.
messages: Cell membrane
messages: Interacts with FTH1.
messages: Iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YDR224C
gene id: 559292:YDR224C
uniprot id: P02293
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by GCN5, a component of the SAGA complex, to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1, a component of the NuA4 histone acetyltransferase (HAT) complex. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription.
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitinated by the RAD6/UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation. Deubiquitination is performed by UBP8 in presence of SGF11.
messages: Nucleus
messages: Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation. H2BS10ph is also formed after H(2)O(2) treatment, and is a step leading to apoptosis.
messages: Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BK7ac = acetylated Lys-8; H2BK7su = sumoylated Lys-8; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK16ac = acetylated Lys-17; H2BK16su = sumoylated Lys-17; H2BK17su = sumoylated Lys-18; H2BK123ub1 = monoubiquitinated Lys-124.

559292:Q0140
gene id: 559292:Q0140
uniprot id: P02381
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). uS3m is essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits (PubMed:7770043).
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uS3m, uS4m and uS5m form the narrow entry site of the mRNA channel.
messages: Mitochondrion

559292:YJR161C
gene id: 559292:YJR161C
uniprot id: P47187
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Membrane
messages: Present with 815 molecules/cell in log phase SD medium.

559292:YDR001C
gene id: 559292:YDR001C
uniprot id: P32356
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by calcium (PubMed:22320399). Activated by protein kinase A (PKA)-mediated phosphorylation (PubMed:22320399).
messages: Belongs to the glycosyl hydrolase 37 family.
messages: Cytoplasm
messages: Hydrolyzes intracellular trehalose to glucose (PubMed:22320399, PubMed:29087344) (Probable). The disaccharide trehalose serves as a storage carbohydrate that is mobilized during nutrient stress (Probable). Regulates the level of trehalose as a protectant for cell integrity during heat stress (PubMed:7883049, PubMed:7730323).
messages: Increases cellular trehalase level during thermal stress (PubMed:7730323). Increases sensitivity to heat shock (PubMed:7730323, PubMed:7883049). Decreases growth on the non-fermentable carbon source glycerol; simultaneous knockout of ATH1 exacerbates the effect (PubMed:7883049).
messages: Induced during thermal stress (at protein level) (PubMed:7883049, PubMed:9276477). Induced by oxidative stress (hydrogen peroxide, sodium arsenite) (at protein level) (PubMed:9276477). Induced by copper stress (at protein level) (PubMed:9276477). Induced by protein synthesis inhibitor (cycloheximide) (PubMed:9276477).
messages: Monomer (PubMed:22320399, PubMed:29087344). Interacts with BMH1 dimers; the interaction is direct and activates NTH1 (PubMed:29087344, PubMed:22320399). Interacts with BMH2 (PubMed:22320399).
messages: Phosphorylated by protein kinase A (PKA); phosphorylation at Ser-60 and Ser-83 is required for activation by the 14-3-3 proteins BMH1 and BMH2.
messages: Present with 1840 molecules/cell in log phase SD medium.

559292:YMR284W
gene id: 559292:YMR284W
uniprot id: P32807
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ku70 family.
messages: Heterodimer of YKU70/HDF1 and YKU80/HDF2.
messages: Nucleus
messages: Present with 892 molecules/cell in log phase SD medium.
messages: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
messages: Sumoylated by MMS21.
messages: telomere

559292:YDR041W
gene id: 559292:YDR041W
uniprot id: Q03201
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 8480 molecules/cell in log phase SD medium.

559292:YNL199C
gene id: 559292:YNL199C
uniprot id: Q01722
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer via the leucine-zipper domain. Forms a complex with a GCR1 homodimer.
messages: Nucleus
messages: Transcriptional activator required for the expression of glycolytic genes. Enhances the CT box-dependent transcriptional activation of a RAP1-GCR1 complex. Required for GCR1 phosphorylation.

559292:YDR014W
gene id: 559292:YDR014W
uniprot id: Q99359
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Involved in resistance to ionizing radiation.
messages: Nucleus
messages: Present with 721 molecules/cell in log phase SD medium.

559292:YMR121C
gene id: 559292:YMR121C
uniprot id: P54780
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 721 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL15 in yeast.

559292:YJR080C
gene id: 559292:YJR080C
uniprot id: P47127
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion
messages: Present with 2290 molecules/cell in log phase SD medium.

559292:YHR026W
gene id: 559292:YHR026W
uniprot id: P23968
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:9030535). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:9030535).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:27776355, PubMed:29526695). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c'' (PubMed:27776355, PubMed:29526695).
messages: Vacuole membrane

559292:YLR466W
gene id: 559292:YLR466W
uniprot id: O13559
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YMR307W
gene id: 559292:YMR307W
uniprot id: P22146
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Extensively N- and O-glycosylated.
messages: Increases cellular chitin level (PubMed:17142567). Increases chitin chain length (PubMed:17142567).
messages: Present with 11000 wall-bound molecules/cell in log phase YPD medium.
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YDR247W
gene id: 559292:YDR247W
uniprot id: Q03785
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Present with 780 molecules/cell in log phase SD medium.
messages: Probable serine/threonine protein kinase involved in the G1-S transition.

559292:YCR094W
gene id: 559292:YCR094W
uniprot id: P25656
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC50/LEM3 family.
messages: Interacts with DRS2. Might function as an essential subunit for this protein.
messages: Late endosome membrane
messages: Present with 589 molecules/cell in log phase SD medium.
messages: Required for polarized cell growth.

559292:YHR159W
gene id: 559292:YHR159W
uniprot id: P38854
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA11 family.
messages: Cytoplasm
messages: Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YHR062C
gene id: 559292:YHR062C
uniprot id: P38786
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
messages: Nucleus
messages: Present with 6300 molecules/cell in log phase SD medium.

559292:YOR246C
gene id: 559292:YOR246C
uniprot id: Q08651
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Exhibits lumenal vesicles within vacuoles suggestive of vacuole fusion/fission defects. Leads to internal accumulation of precursor CPY.
messages: Lipid droplet
messages: Membrane
messages: N-glycosylated.
messages: Present with 892 molecules/cell in log phase SD medium.
messages: Probable dehydrogenase required for replication of Brome mosaic virus. Involved in vacuolar processing and morphology.

559292:YNR071C
gene id: 559292:YNR071C
uniprot id: P53757
names: Similarity
messages: Belongs to the aldose epimerase family.

559292:YBL058W
gene id: 559292:YBL058W
uniprot id: P34223
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a complex composed of CDC48, NPL4, UFD1, DOA1, SHP1 and deubiquitinase OTU1 (PubMed:16427015). Interacts with CDC48 (PubMed:15258615).
messages: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Direct or indirect positive regulator of GLC7 activity.
messages: Nucleus
messages: Present with 3200 molecules/cell in log phase SD medium.

559292:YNR059W
gene id: 559292:YNR059W
uniprot id: P53745
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Membrane

559292:YNL019C
gene id: 559292:YNL019C
uniprot id: P53975
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To yeast YNL033w.

559292:YCL073C
gene id: 559292:YCL073C
uniprot id: P25596
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: By iron depletion and by heat.
messages: Cell membrane
messages: Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway.
messages: Vacuole membrane

559292:YER017C
gene id: 559292:YER017C
uniprot id: P39925
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides.
messages: Binds 1 zinc ion per subunit.
messages: Component of the 850 kDa m-AAA protease complex (YTA10-12) which consists of multiple copies of RCA1 and AFG3.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.
messages: Mitochondrion inner membrane
messages: Present with 3870 molecules/cell in log phase SD medium.

559292:YBR170C
gene id: 559292:YBR170C
uniprot id: P33755
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NPL4 family.
messages: Component of the heterotrimeric CDC48-NPL4-UFD1 ATPase complex (PubMed:16873066). The CDC48-NPL4-UFD1 ATPase complex interacts with the HRD1 ubiquitin ligase complex composed of the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873066). Interaction between the complexes is mediated by interaction between CDC48-NPL4-UFD1 complex member CDC48 and HRD1 complex member UBX2 (PubMed:16873066). Forms a complex composed of CDC48, NPL4, UFD1, DOA1, SHP1 and deubiquitinase OTU1 (PubMed:16427015). Interacts with CDC48, UFD1 and VMS1 (PubMed:11598205, PubMed:11733065, PubMed:11739805, PubMed:21070972, PubMed:31249135).
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: Present with 1050 molecules/cell in log phase SD medium.
messages: Substrate-recruiting cofactor of the CDC48-NPL4-UFD1 segregase (PubMed:31249135). Assists CDC48 in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation (PubMed:11739805, PubMed:11740563, PubMed:11847109). Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus (PubMed:8930904, PubMed:11733065). Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1 (PubMed:11733065). Regulates ubiquitin-mediated mitochondria protein degradation (PubMed:31249135). Involved in spindle disassembly probably by promoting the degradation of spindle assemby factors ASE1 and CDC5 at the end of mitosis (PubMed:14636562).
messages: perinuclear region

559292:YJL083W
gene id: 559292:YJL083W
uniprot id: P47030
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the IRS4 family.
messages: Interacts with INP51.
messages: Present with 396 molecules/cell in log phase SD medium.
messages: With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2.

559292:YBR215W
gene id: 559292:YBR215W
uniprot id: Q01448
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes localization of HIR1 and RTT106 to the HTA1-HTB1 promoter.
messages: Belongs to the HPC2 family.
messages: Chromosome
messages: Component of the HIR complex, composed of HIR1, HIR2, HIR3 and HPC2 (PubMed:16264190, PubMed:16303565). This complex may consist of one copy of HIR1 and HIR3 and two copies of HIR2 and HPC2 (PubMed:16264190). The HIR complex interacts with ASF1 (PubMed:16303565). Interacts with RTT106 (PubMed:19683497).
messages: Component of the HIR complex, which functions as a histone chaperone that cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
messages: Nucleus
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YLR213C
gene id: 559292:YLR213C
uniprot id: Q05790
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 16 family. CRR1 subfamily.
messages: Expressed in spores.
messages: Expression is increased in low copper conditions, probably through the transcription regulation by the copper regulon transcription factor MAC1.
messages: Spore specific glycosidase involved in spore wall assembly during sporulation. May be involved in copper import.
messages: Spore wall

559292:YMR062C
gene id: 559292:YMR062C
uniprot id: Q04728
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
messages: Heterodimer of an alpha and a beta chain.
messages: Inhibited by ornithine.
messages: Mitochondrion matrix
messages: The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.

559292:YLR448W
gene id: 559292:YLR448W
uniprot id: P05739
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL6 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 38400 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL6 in yeast.

559292:YHR005C-A
gene id: 559292:YHR005C-A
uniprot id: P87108
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM12 component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM9, it may function as a substrate sensor.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.

559292:YKR023W
gene id: 559292:YKR023W
uniprot id: P36119
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RQT (ribosome quality control trigger) complex, composed of SLH1, CUE3, and RQT4 (PubMed:28757607, PubMed:32203490). Interacts with SLH1 (PubMed:28757607). Interacts with CUE3 (PubMed:28757607, PubMed:28223409). Interacts with HEL2 (PubMed:28757607). Associates with translating ribosomes (PubMed:28757607, PubMed:28223409).
messages: Defective activation of the ribosome quality control (RQC) pathway (PubMed:28757607). Mildly defective ribosome stalling induced by RNA arrest sequences (PubMed:28223409). Sensitive to anisomycin (stalls ribosomes in the rotated state) (PubMed:28757607).
messages: Functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation.
messages: Present with 1710 molecules/cell in log phase SD medium.
messages: cytosol

559292:YDR363W
gene id: 559292:YDR363W
uniprot id: Q06340
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a cullin-RING ligase (CRL)-like complex composed of at least the cullin RTT101, a linker protein MMS1, and the potential substrate receptor ESC2. Interacts with RTT101 and MMS1. Interacts with SIR2.
messages: Cytoplasm
messages: May be a substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-ESC2). Involved in HMR and telomere silencing via the recruitment or stabilizing of the SIR (silent information regulators) complex.
messages: Nucleus
messages: Present with 1890 molecules/cell in log phase SD medium.
messages: The 2 SUMO-like regions, although related to ubiquitin domains lack the conserved acceptor Gly residue in position 456.

559292:YOL111C
gene id: 559292:YOL111C
uniprot id: Q12285
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with GET4.
messages: Nucleus
messages: Present with 6510 molecules/cell in log phase SD medium.
messages: Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.
messages: cytosol

559292:YKL019W
gene id: 559292:YKL019W
uniprot id: P29703
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Cytoplasm
messages: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. If X is Ser, Ala, Met, Cys, or Gln, then the protein is farnesylated, if X is Leu or Phe, then the protein is geranylgeranylated. The alpha subunit wraps partly around the beta subunit forming part of the active site. The beta subunit is responsible for isoprenoid and peptide-binding.
messages: Farnesyltransferase and geranyl-geranyltransferase share a common alpha subunit (RAM2) (Probable). Protein farnesyltransferase is a heterodimer of alpha subunit RAM2 and beta subunit RAM1 (PubMed:1763050). Protein geranyl-geranyltransferase type-1 is a heterodimer of alpha subunit RAM2 and beta subunit CDC43 (PubMed:1400380, PubMed:9174352).
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YMR114C
gene id: 559292:YMR114C
uniprot id: Q04471
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).

559292:YGR038W
gene id: 559292:YGR038W
uniprot id: P53224
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis. Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity.
messages: Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3.
messages: Endoplasmic reticulum membrane
messages: Phosphorylated in case of disruption of sphingolipid synthesis. Phosphorylation regulates inhibitory activity of serine palmitoyltransferases (LCB1 and LCB2).
messages: Present with 2800 molecules/cell in log phase SD medium.

559292:YGL207W
gene id: 559292:YGL207W
uniprot id: P32558
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Transcription elongation is promoted by the repression of transcription initiation from cryptic sites. Also acts in establishing transcription initiation complexes and promotes SPT15/TBP-binding to a TATA box. Together with replication factor-A protein (RPA), FACT may play a role in nucleosome deposition during DNA replication.
messages: Forms a stable heterodimer with POB3 (PubMed:9832518, PubMed:9705338, PubMed:10413469). The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 (NHP6A or NHP6B) to form the FACT (yFACT or SNP) complex (PubMed:11432837, PubMed:11313475, PubMed:12952948). The FACT complex interacts with the CK2 (casein kinase II) complex subunits CKA1, CKA2, CKB1 and CKB2 and the components of the transcription machinery CHD1, CTR9, PAF1 and CDC73 (PubMed:12682017, PubMed:12242279). The FACT complex interacts with the PAF1 complex (PubMed:11927560). Interacts with POL1 (PubMed:9199353). Interacts with SAS3 (PubMed:10817755). Interacts with YTA7 (PubMed:22156209).
messages: Nucleus
messages: Present with 18500 molecules/cell in log phase SD medium.

559292:YPL268W
gene id: 559292:YPL268W
uniprot id: P32383
names: Function
names: Subunit
messages: Interacts with SGD1.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1.

559292:YMR068W
gene id: 559292:YMR068W
uniprot id: Q04749
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
messages: Present with 1180 molecules/cell in log phase SD medium.
messages: The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin. AVO2 is peripherally associated to AVO1 and TSC11.
messages: Vacuole membrane

559292:YGL158W
gene id: 559292:YGL158W
uniprot id: P38622
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

559292:YOR198C
gene id: 559292:YOR198C
uniprot id: P38934
names: Domain
names: Function
names: Miscellaneous
messages: Implicated in secretion, nuclear segregation and in maintenance of cell size.
messages: Present with 33400 molecules/cell in log phase SD medium.
messages: Three regions of the protein are predicted to form a coiled-coil. It may adopt a rod-shaped rather than a globular configuration.

559292:YPR193C
gene id: 559292:YPR193C
uniprot id: Q06592
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoacetylates in an intermolecular reaction.
messages: Belongs to the acetyltransferase family. GNAT subfamily.
messages: Forms homodimers in the absence, and homotetramers in the presence of acetyl-CoA.
messages: N-acetyltransferase that acetylates histone H3 at 'Lys-14' and histone H4 at 'Lys-5' and 'Lys-12'. Also acetylates polyamines like putrescine, spermidine and spermine, and certain other small basic proteins like nuclear HMG proteins.

559292:YER155C
gene id: 559292:YER155C
uniprot id: P39960
names: Function
names: Miscellaneous
messages: GTPase-activating protein (GAP) for RHO1 and RHO2. Involved in the control of cellular morphogenesis. Required for proper bud site selection and bud emergence.
messages: Present with 1230 molecules/cell in log phase SD medium.

559292:YDR108W
gene id: 559292:YDR108W
uniprot id: P46944
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRS85 family.
messages: Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.
messages: Preautophagosomal structure
messages: Present with 8760 molecules/cell in log phase SD medium.
messages: Specific subunit of the TRAPP III complex that acts as an autophagy-specific guanine nucleotide exchange factor (GEF) for YPT1. TRS85 directs the TRAPP III complex to the phagophore assembly site (PAS) that is involved in autophagosome formation. Required for membrane expansion during autophagy and the CVT pathway. Required for sporulation. Has a role late in meiosis following DNA replication.

559292:YDL190C
gene id: 559292:YDL190C
uniprot id: P54860
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to CDC48 and elongates mono- and diubiquitinated ERAD substrates presented by the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to RAD23 and DSK2, which target them to the proteasome. Has E3 ubiquitin-protein ligase activity, accepting ubiquitin from its cognate E2 ubiquitin-conjugating enzyme UBC4. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. Promotes ubiquitin chain elongation at 'Lys-48' on the DOA10 substrate PEX29. Also involved in the proteolytic processing of the ER-bound transcription factor SPT23.
messages: Interacts with CDC48. Interacts with the ubiquitin-like domain of RAD23 and DSK2. Interacts with PEX29.
messages: Nucleus
messages: Present with 2600 molecules/cell in log phase SD medium.
messages: The U-box domain is required for the ubiquitin protein ligase activity.

559292:YML032C
gene id: 559292:YML032C
uniprot id: P06778
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD52 family.
messages: Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
messages: Nucleus
messages: Part of a complex that includes RAD51, RAD52 and RAD59. Interacts with SAW1.
messages: Present with 1080 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-5 of isoform 1.
messages: Produced by alternative initiation at Met-7 of isoform 1.

559292:YDR033W
gene id: 559292:YDR033W
uniprot id: Q12117
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Bud
messages: Cell membrane
messages: Mitochondrion
messages: Present with 182000 molecules/cell in log phase SD medium.

559292:YDR519W
gene id: 559292:YDR519W
uniprot id: P32472
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
messages: Endoplasmic reticulum membrane
messages: Inhibited by both FK506 and rapamycin. Binds FK506 with 15-fold lower affinity than FKB1.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FKBP-13 may play a role in protein trafficking in the ER.
messages: Present with 5400 molecules/cell in log phase SD medium.

559292:YML051W
gene id: 559292:YML051W
uniprot id: P04387
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Monomer.
messages: Present with 784 molecules/cell in log phase SD medium.
messages: This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It binds to GAL4 and so blocks transcriptional activation by it, in the absence of an inducing sugar.
messages: To K.lactis GAL80.

559292:YNL023C
gene id: 559292:YNL023C
uniprot id: P53971
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFX1 family.
messages: Cytoplasm
messages: Interacts with FPR1.
messages: May play a role in transcription regulation.
messages: Nucleus
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YDR118W
gene id: 559292:YDR118W
uniprot id: Q04601
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1332 molecules/cell in log phase SD medium.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1.

559292:YMR273C
gene id: 559292:YMR273C
uniprot id: P50111
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'ZDS' means 'zillion different screens' as both ZDS1 and ZDS2 have been found by a wide variety of genetic screens.
messages: Cytoplasm
messages: Has a role in establishing cell polarity. Together with cAMP-dependent protein kinase regulatory subunit BCY1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways.
messages: Interacts with BCY1, DBP5, GFD1 and SKG6.
messages: Present with 279 molecules/cell in log phase SD medium.
messages: To yeast ZDS2/MCS1.
messages: When associated with DBP5, GFD1 and nucleoporins at the cytosolic fibrils of the nuclear pore complex, is required for mRNA export form the nucleus.

559292:YPL220W
gene id: 559292:YPL220W
uniprot id: P0CX43
uniprot id: P0CX44
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL1 forms part of the L1 stalk (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 116000 molecules/cell in log phase SD medium.
messages: Present with 265000 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL1 in yeast.

559292:YOL008W
gene id: 559292:YOL008W
uniprot id: Q08058
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Mitochondrion inner membrane
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

559292:YER168C
gene id: 559292:YER168C
uniprot id: P21269
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus
messages: Present with 13500 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-10 of isoform Mitochondrial.
messages: Produced by alternative initiation at Met-18 of isoform Mitochondrial.
messages: This enzyme carries out synthesis of the tRNA CCA terminus without the direction of a template using the multiple accepting and donating subsites within its active site.

559292:YDR013W
gene id: 559292:YDR013W
uniprot id: Q12488
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3. Interacts with PSF2.
messages: Nucleus
messages: Present with 1431 molecules/cell in log phase SD medium.
messages: Required for DNA replication. Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery. Required for the chromatin binding of CDC45.

559292:YDR100W
gene id: 559292:YDR100W
uniprot id: Q03860
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TVP15 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Interacts with TVP18.
messages: Present with 4540 molecules/cell in log phase SD medium.

559292:YLR258W
gene id: 559292:YLR258W
uniprot id: P27472
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Allosteric activation by glucose-6-phosphate, and phosphorylation by a cAMP-dependent kinase.
messages: Belongs to the glycosyltransferase 3 family.
messages: Interacts with PCL10.
messages: Phosphorylated by the cyclin-CDK PCL10-PHO85. Phosphorylation causes inactivation of enzyme.
messages: Present with 14600 molecules/cell in log phase SD medium.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen.

559292:YDR138W
gene id: 559292:YDR138W
uniprot id: P17629
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the THO complex, which is composed of HPR1, MFT1, THO2 and THP2. Together with SUB2, TEX1 and YRA1, THO forms the transcription/export (TREX) complex. THO associates with DNA and RNA in vitro.
messages: Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
messages: HPR1 is not required for sporulation, and is not essential for DNA repair. It is probably not a DNA topoisomerase.
messages: Nucleus
messages: Present with 1340 molecules/cell in log phase SD medium.

559292:YOR145C
gene id: 559292:YOR145C
uniprot id: Q99216
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNO1 family.
messages: Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex). Interacts with NOB1.
messages: Cytoplasm
messages: Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species. Recruits DIM1 to nucleolar pre-RNAs. Indirectly required for cleavage at the A2 site of the 20S pre-rRNA, forming 18S rRNA, and at A1 and A2 sites of other pre-rRNAs.
messages: nucleolus

559292:YOR023C
gene id: 559292:YOR023C
uniprot id: Q12433
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 0.8 MDa ADA complex, which at least consists of ADA2, ADA3, AHC1 and GCN5.
messages: Cytoplasm
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complex ADA. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. AHC1 is required for the overall structural integrity of the ADA complex.
messages: Nucleus
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YKL216W
gene id: 559292:YKL216W
uniprot id: P28272
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. Does not use oxaloacetate or NAD or NADP as electron acceptors.
messages: Cytoplasm
messages: Homodimer.
messages: Present with 264000 molecules/cell in log phase SD medium.
messages: The activity is independent of the presence of oxygen.

559292:YHR191C
gene id: 559292:YHR191C
uniprot id: P38877
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF8 family.
messages: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5.
messages: Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
messages: Nucleus

559292:YLR077W
gene id: 559292:YLR077W
uniprot id: Q08023
names: Subcellular Location Annotation
messages: Mitochondrion membrane

559292:YJL058C
gene id: 559292:YJL058C
uniprot id: P47041
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BIT61 family.
messages: Cell membrane
messages: Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
messages: Present with 1960 molecules/cell in log phase SD medium.
messages: The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin.
messages: Vacuole membrane

559292:YCL064C
gene id: 559292:YCL064C
uniprot id: P25379
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine/threonine dehydratase family.
messages: Mitochondrion
messages: Present with 36600 molecules/cell in log phase SD medium.

559292:YML055W
gene id: 559292:YML055W
uniprot id: Q04969
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (PubMed:8910564, PubMed:9148931). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (PubMed:10921929). Interacts with SBH1 and SEB2/SBH2 (PubMed:10921929).
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:8910564, PubMed:10921929). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (PubMed:8910564, PubMed:10921929).
messages: Endoplasmic reticulum membrane
messages: Important for signal peptidase activity and cell viability at high temperatures.
messages: Present with 4890 molecules/cell in log phase SD medium.

559292:YDR343C
gene id: 559292:YDR343C
uniprot id: P39003
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: High-affinity glucose transporter.
messages: Membrane

559292:YJL010C
gene id: 559292:YJL010C
uniprot id: P47077
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP9 family.
messages: Component of the 90S pre-ribosome. Component of the pre-40S ribosome.
messages: Present with 2930 molecules/cell in log phase SD medium.
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Component of the 90S pre-ribosome involved in production of 18S rRNA and assembly of small ribosomal subunit. Component of the pre-40S ribosome required for release from the nucleolus.
messages: nucleolus

559292:YLR287C
gene id: 559292:YLR287C
uniprot id: Q05881
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 9100 molecules/cell in log phase SD medium.

559292:YOL156W
gene id: 559292:YOL156W
uniprot id: P54862
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Probable glucose transporter.

559292:YPL148C
gene id: 559292:YPL148C
uniprot id: Q12036
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Mitochondrion
messages: Present with 486 molecules/cell in log phase SD medium.
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein.

559292:YGR133W
gene id: 559292:YGR133W
uniprot id: P29340
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Essential for peroxisome biogenesis (By similarity) (PubMed:17550898, PubMed:18644345). Required for UBC4-independent ubiquitination of PEX5 (PubMed:17550898, PubMed:18644345).
messages: Peroxisome

559292:YLR414C
gene id: 559292:YLR414C
uniprot id: Q06991
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUR7 family.
messages: By the HOG1 MAPK, cell wall perturbations, and nitrogen stress. Expression is controlled by the MSS11 pseudohyphal growth transcription factor.
messages: Cell membrane
messages: Contributes to the wild-type cellular response to nitrogen stress through signaling pathways that regulate the expression of genes involved in amino acid biosynthesis. Required for wild-type filamentous growth, cell growth, and cell-cell adhesion.
messages: N-glycosylated.
messages: Present with 1660 molecules/cell in log phase SD medium.

559292:YNL136W
gene id: 559292:YNL136W
uniprot id: P53911
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF7 family.
messages: Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YNL274C
gene id: 559292:YNL274C
uniprot id: P53839
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Cytoplasm
messages: Glyoxylate reductase that reversibly reduces glyoxylate to glycolate, or alternatively hydroxypyruvate to D-glycerate, using either NADPH or NADH as a cosubstrate (PubMed:17173333). Does not act as a hydroxyisocaproate dehydrogenase even though it also has minor activity on alpha-ketoisocaproate (PubMed:17173333).
messages: Leads to higher biomass concentration after diauxic shift.
messages: Mitochondrion
messages: Nucleus
messages: Present with 3280 molecules/cell in log phase SD medium.

559292:YFL026W
gene id: 559292:YFL026W
uniprot id: D6VTK4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 4 family.
messages: Membrane
messages: N-glycosylation may be involved in the sorting process for misfolded STE2 protein.
messages: Receptor for the peptide pheromone alpha factor, the mating factor of yeast.

559292:YKL007W
gene id: 559292:YKL007W
uniprot id: P28495
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: Present with 4380 molecules/cell in log phase SD medium.

559292:YCL016C
gene id: 559292:YCL016C
uniprot id: P25559
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the DCC1 family.
messages: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5.
messages: Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
messages: Present with 1660 molecules/cell in log phase SD medium.

559292:YLR403W
gene id: 559292:YLR403W
uniprot id: P32432
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the target of rapamycin complex 1 (TORC1) in a rapamycin-dependent manner. Interacts with MRS6.
messages: It is uncertain whether Met-1 or Met-6 is the initiator.
messages: Nucleus
messages: Phosphorylated by TORC1 kinase at multiple sites. Phosphorylation regulates nuclear localization and RP promoter binding.
messages: Present with 259 molecules/cell in log phase SD medium.
messages: The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
messages: Transcription factor that regulates ribosomal protein (RP) and ribosome biogenesis (Ribi) gene expression in response to nutrients and stress. Promotes RP gene expression under optimal growth conditions. Leaves the nucleus upon environmental challenges, resulting in a down-regulation of RP gene transcription. The effect of the environmental cues on SFP1 localization is mediated through the TOR pathway. Also regulates the expression of genes involved in the G2/M transition during the mitotic cell cycle and the DNA-damage response. Required for carbon-source modulation of cell size.
messages: [ISP+] is the prion form of SFP1. [ISP+] is the result of a conformational change of the cellular SFP1 protein that becomes self-propagating and infectious. This conformational change generates a form of SFP1 that assembles into amyloid fibrils. [ISP+]-aggregates accumulate in the nucleus, and results in significantly larger cell size and increased drug resistance (PubMed:20498075). [ISP+] can be cured by GdnHCl (PubMed:11805042). It is speculated that prion properties of transcription factors may generate an optimized phenotypic heterogeneity that buffers yeast populations against diverse environmental insults (PubMed:20498075).

559292:YDR489W
gene id: 559292:YDR489W
uniprot id: Q03406
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS4/SLD5 family.
messages: Component of the GINS complex which is a heterotetramer composed of SLD5, PSF1, PSF2 and PSF3. Interacts with PSF2.
messages: Nucleus
messages: Required for DNA replication. Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.

559292:YML129C
gene id: 559292:YML129C
uniprot id: P39103
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion membrane
messages: Present with 6840 molecules/cell in log phase SD medium.
messages: Required for the synthesis of yeast cytochrome oxidase.

559292:YOR311C
gene id: 559292:YOR311C
uniprot id: Q12382
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DGK1 family.
messages: CKII-mediated phosphorylation of Ser-45 and Ser-46 regulates its function in the production of PA.
messages: CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. Counteracts the activity of PA phosphatase PAH1/SMP2, controlling the levels of PA and DAG for the synthesis of triacylglycerol and membrane phospholipids (PubMed:18458075, PubMed:27834677). May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus (PubMed:11481671). Required to convert triacylglycerol-derived DAG to PA for phospholipid synthesis during growth resumption from stationary phase in the absence of de novo fatty acid synthesis (PubMed:21071438). Involved in the resistance to nickel chloride and nalidixic acid (PubMed:10407277).
messages: Endoplasmic reticulum membrane
messages: Inhibited by N-ethylmaleimide, dCTP, and sphingoid bases including sphinganine, sphingosine and phytosphingosine. DAG pyrophosphate, cardiolipin, CDP-DAG, and lyso-PA inhibited activity by 23-66%. Also inhibited by Ca(2+) concentrations of more than 1 mM, by addition of EDTA or EGTA at 5 mM, and by 5 mM Mn(2+) and Zn(2+). Stimulated by major membrane phospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol, and phosphatidate. Also stimulated to a maximum by addition of TritonX-100 at a concentration of 1 mM, followed by an apparent inhibition of activity at concentrations above 1 mM.
messages: Nucleus membrane
messages: Present with 784 molecules/cell in log phase SD medium.
messages: Rescues the lethality of dephosphorylated PAH1/SMP2. Overexpression causes the appearance of phosphatidate-enriched membranes around the nucleus, leading to expansion of the nuclear membrane without proliferation of the cortical endoplasmic reticulum membrane. Deletion restores normal nuclear structure in PAH1/SMP2 deleted cells and returns the level of INO1 mRNA to normal. Deletion does not affect the abnormal levels of phosphatidylinositol and major neutral lipid triacylglycerol seen in the PAH1/SMP2 deletion mutant.

559292:YMR113W
gene id: 559292:YMR113W
uniprot id: Q12676
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folylpolyglutamate synthase family.
messages: Cytoplasm
messages: Glutamate-adding enzyme which catalyzes the binding of the first glutamyl side chain to dihydropteroate. Leads to the de nove synthesis of tetrahydrofolate.
messages: Present with 2340 molecules/cell in log phase SD medium.

559292:YLR084C
gene id: 559292:YLR084C
uniprot id: Q12465
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Bud tip
messages: Cell membrane
messages: Glycosylated.
messages: Interacts with RAX1.
messages: Present with 3670 molecules/cell in log phase SD medium.
messages: Required for the maintenance of the bipolar budding pattern. Involved in selecting bud sites at both the distal and proximal poles of daughter cells as well as near previously used division sites on mother cells.

559292:YER107C
gene id: 559292:YER107C
uniprot id: P40066
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat rae1 family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. GLE2 interacts with the NUP82 subcomplex via NUP116. It also interacts with NUP42.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically important for nuclear mRNA export.
messages: Nucleus membrane
messages: Present with 1820 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YOL112W
gene id: 559292:YOL112W
uniprot id: Q12317
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Bud
messages: Bud neck
messages: Cytoplasm
messages: Present with 1730 molecules/cell in log phase SD medium.
messages: Regulates exocytosis by functioning as a GAP for SEC4. Also required for efficient polarization of the actin patches.

559292:YGL226W
gene id: 559292:YGL226W
uniprot id: P53077
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: May be involved in telomere capping.
messages: Mitochondrion
messages: Present with 1170 molecules/cell in log phase SD medium.

559292:YGL233W
gene id: 559292:YGL233W
uniprot id: P22224
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC15 family.
messages: Cell membrane
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Cytoplasm
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84. Interacts with SEC4.

559292:YCL056C
gene id: 559292:YCL056C
uniprot id: P25584
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homooligomer. Interacts with PEX11, PEX25 and PEX27.
messages: In concert with the three peroxisome divisional factors, PEX11, PEX25 and PEX27, controls peroxisome morphology and abundance under conditions of peroxisome proliferation. Maintains mature peroxisomes in actively dividing cells.
messages: Peroxisome membrane

559292:YGR295C
gene id: 559292:YGR295C
uniprot id: P53344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Membrane

559292:YIL139C
gene id: 559292:YIL139C
uniprot id: P38927
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAD2 family.
messages: Forms DNA polymerase zeta with REV3 (PubMed:8658138). Interacts with REV1 (PubMed:18242152).
messages: Mitochondrion
messages: Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites.

559292:YCL037C
gene id: 559292:YCL037C
uniprot id: P25567
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with HAP1. Component of the HMC including HAP1, SRO9 and YDJ1.
messages: May overlap in function with tropomyosin and may be involved in organization of actin filaments. Acts as a multicopy suppressor of RHO3 mutation. RNA-binding protein which may modulate mRNA translation. Involved in heme regulation of HAP1, as a component of the high-molecular-weight complex (HMC).
messages: Present with 8430 molecules/cell in log phase SD medium.

559292:YGR199W
gene id: 559292:YGR199W
uniprot id: P42934
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects GAS1 and GGP1 O-mannosylation.
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: May form a hetodimer with PMT4.
messages: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

559292:YLR072W
gene id: 559292:YLR072W
uniprot id: Q08001
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YSP2 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with the ERMES complex.
messages: Involved in regulation of various organellar membrane contact sites (PubMed:26119743). May be involved in sterol transfer between intracellular membranes (PubMed:26001273). Selectively transports sterols between membranes in vitro. Involved in stress-dependent formation of sterol-enriched vacuolar membrane domains (PubMed:25987606).
messages: The VASt domain bind sterols.

559292:YAL017W
gene id: 559292:YAL017W
uniprot id: P31374
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Present with 967 molecules/cell in log phase SD medium.
messages: Serine/threonine-protein kinase involved in the control of sugar metabolism and translation. Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis. This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis.

559292:YPL043W
gene id: 559292:YPL043W
uniprot id: P37838
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with NOP1.
messages: Present with 4990 molecules/cell in log phase SD medium.
messages: Required for 60S ribosomal subunit synthesis. Probably involved in the processing of 27S rRNA to produce mature 25S rRNA.
messages: nucleolus

559292:YKL058W
gene id: 559292:YKL058W
uniprot id: P32774
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 2 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 3910 molecules/cell in log phase SD medium.
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
messages: TFIIA is a heterodimer composed of the large TOA1 and a small TOA2 subunits. Interacts with TBP. Interacts with TAF11. Interacts with KAP122.

559292:YER015W
gene id: 559292:YER015W
uniprot id: P39518
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Activates endogenous medium-chain (MCFA) and long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:8206942). Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated (PubMed:8206942). Is the main if not exclusive MCFA (octanoate, decanoate and laureate) acyl-CoA ligase. Required for efficient MCFA beta-oxidation inside peroxisomes. Facilitates the transport of MCFAs into peroxisomes by passive diffusion, by decreasing the intraorganellar MCFA concentration (PubMed:8670886). Also esterifies LCFAs in the peroxisome matrix. The LCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane (PubMed:22493507).
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: By oleate.
messages: Cytoplasm
messages: Peroxisome membrane
messages: Present with 358 molecules/cell in log phase SD medium.
messages: The FACS motif is required for catalytic activity and substrate specificity.

559292:YLR253W
gene id: 559292:YLR253W
uniprot id: Q06567
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression (PubMed:25683707). Involved in mitochondrial lipid homeostasis (PubMed:23781023).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 1600 molecules/cell in log phase SD medium.

559292:YDR051C
gene id: 559292:YDR051C
uniprot id: Q99288
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family.
messages: Cytoplasm
messages: Metal-independent, broad-range acid phosphatase. Involved, either directly or indirectly, in the bidirectional transport of sterols between the endoplasmic reticulum and the plasma membrane.
messages: Nucleus
messages: Present with 3170 molecules/cell in log phase SD medium.

559292:YOR182C
gene id: 559292:YOR182C
uniprot id: P0CX33
uniprot id: P0CX34
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS30 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 18500 molecules/cell in log phase SD medium.
messages: Present with 37600 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS30 in yeast.

559292:YBL087C
gene id: 559292:YBL087C
uniprot id: P0CX41
uniprot id: P0CX42
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Methylated by RKM1 at 2 different sites, but it is unclear which are the 2 methylated residues among Lys-40, Lys-106 and/or Lys-110.
messages: There are 2 genes for uL14 in yeast.

559292:YMR115W
gene id: 559292:YMR115W
uniprot id: Q04472
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MGR3 family.
messages: Component of the mitochondrial inner membrane i-AAA protease supercomplex composed of MGR1, MGR3 and YME1. With MGR1, forms a subcomplex that binds to YME1 and to substrates to facilitate proteolysis.
messages: Component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. Together with MGR1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation. Required for growth of cells lacking the mitochondrial genome.
messages: Mitochondrion inner membrane
messages: Present with 8970 molecules/cell in log phase SD medium.
messages: Reduces proteolysis by YME1.

559292:YPR072W
gene id: 559292:YPR072W
uniprot id: Q12514
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Forms a NOT protein complex that comprises NOT1, NOT2, NOT3, NOT4 and NOT5. Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1 and NOT2. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.
messages: Nucleus
messages: Present with 5110 molecules/cell in log phase SD medium.

559292:YJR123W
gene id: 559292:YJR123W
uniprot id: P26783
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.

559292:YDL216C
gene id: 559292:YDL216C
uniprot id: Q12468
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the mating pheromone response.
messages: Component of a COP9 signalosome-like (CSN) complex, composed of at least RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. Within this complex it probably interacts directly with CSN12. Also interacts with RPN5.
messages: Cytoplasm
messages: Nucleus
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).

559292:YDR441C
gene id: 559292:YDR441C
uniprot id: P36973
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. May lack catalytic activity.
messages: Cytoplasm
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YGL062W
gene id: 559292:YGL062W
uniprot id: P11154
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Present with 12500 molecules/cell in log phase SD medium.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

559292:YAR018C
gene id: 559292:YAR018C
uniprot id: P22209
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: This protein is probably a serine/threonine protein kinase.

559292:YFL020C
gene id: 559292:YFL020C
uniprot id: P43575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Membrane

559292:YBL047C
gene id: 559292:YBL047C
uniprot id: P34216
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Cytoplasm
messages: Functions at the internalization step of the clathrin-mediated endocytosis (CME) as an early-acting scaffold protein. Requires clathrin adapter proteins, ENT1/2 and YAP1801/2, for normal spatiotemporal dynamics and viability. Binds to biological membranes in a ubiquitin-dependent manner.
messages: Interacts (via UBA domain) with monoubiquitin and ENT1 (via asparagine-proline-phenylalanine tripeptide motif called NPF). Interacts with PAL1 and SYP1.
messages: Present with 1380 molecules/cell in log phase SD medium.
messages: Random budding pattern and morphological defects. Defects in fluid-phase endocytosis and defective internalization of the pheromone alpha-factor and uracil permease. Deletion has only a small impact on actin cytoskeleton organization. Deletion shows synthetic growth defects with thermosensitive mutants of PAN1, END3 and RSP5.

559292:YJR145C
gene id: 559292:YJR145C
uniprot id: P0CX35
uniprot id: P0CX36
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS4 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 102000 molecules/cell in log phase SD medium.
messages: Present with 573 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS4 in yeast.

559292:YLR464W
gene id: 559292:YLR464W
uniprot id: P0CX16
uniprot id: P0CX17
names: Caution
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Could be the product of a pseudogene. Although strongly related to DNA helicases, it lacks the helicase domains, suggesting that it has no helicase activity.

559292:YLR116W
gene id: 559292:YLR116W
uniprot id: Q12186
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBP/SF1 family.
messages: Interacts with MUD2 and PRP40. The proline-rich sequence of this protein interacts with the GYF domains of SMY2 and SYH1.
messages: Nucleus
messages: Present with 4380 molecules/cell in log phase SD medium.
messages: Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. 2 commitment complexes, CC1 and CC2, have been defined. CC1 is a basal complex dependent only on the 5'-splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5'-splice site region. This protein is involved in CC2 formation where it binds to the snRNP U1-associated protein PRP40, bridging the U1 snRNP-associated 5'-splice site and the MSL5-associated branch point 3' intron splice site. Involved in nuclear retention of pre-mRNA.

559292:YLR453C
gene id: 559292:YLR453C
uniprot id: Q06208
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with RIF1 and RAP1 C-terminus.
messages: Involved in transcriptional silencing and telomere length regulation. Its role in telomere length regulation results from either a block in elongation or promoting degradation of the telomere ends. Loss of RIF1 function results in derepression of an HMR silencer, whose ARS consensus element has been deleted, and in the elongation of telomeres. RAP1 may target the binding of RIF1 to silencers and telomeres.
messages: Nucleus
messages: Present with 589 molecules/cell in log phase SD medium.
messages: telomere

559292:YLR390W
gene id: 559292:YLR390W
uniprot id: Q06011
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: May be involved in cell wall organization and biogenesis.
messages: Mitochondrion membrane
messages: Present with 1890 molecules/cell in log phase SD medium.

559292:YDR414C
gene id: 559292:YDR414C
uniprot id: P16151
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD1 family.
messages: Endoplasmic reticulum membrane
messages: Required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus.

559292:YDR366C
gene id: 559292:YDR366C
uniprot id: P87287
names: Subcellular Location Annotation
messages: Membrane

559292:YGL225W
gene id: 559292:YGL225W
uniprot id: P40107
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity.
messages: Present with 31900 molecules/cell in log phase SD medium.

559292:YOR011W
gene id: 559292:YOR011W
uniprot id: Q08409
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane
messages: Transporter involved in the uptake of sterol.

559292:YDR065W
gene id: 559292:YDR065W
uniprot id: Q12167
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG1 family.
messages: Essential for respiratory growth and required for mitochondrial protein synthesis. Required for vacuolar acidification.
messages: Mitochondrion
messages: N-glycosylated. Glycosylation is important for correct localization of the protein.
messages: Present with 1670 molecules/cell in log phase SD medium.

559292:YGR180C
gene id: 559292:YGR180C
uniprot id: P49723
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Heterotetramer of two large (R1) and two small (R2) subunits. S.cerevisiae has two different R1 subunits (RNR1 and RNR3) and two different R2 subunits (RNR2 and RNR4). The functional form of the small subunits is a RNR2-RNR4 heterodimer, where RNR2 provides the iron-radical center and RNR4 is required for proper folding of RNR2 and assembly with the large subunits. Under normal growth conditions, the active form of the large subunits is a homodimer of the constitutively expressed RNR1. In damaged cells or cells arrested for DNA synthesis, the reductase consists of multiple species because of the association of the small subunits (RNR2-RNR4) with either the RNR1 homodimer or a heterodimer of RNR1 and the damage-inducible RNR3. Interacts with DIF1.
messages: Induced by DNA-damage.
messages: Lacks 3 iron-binding residues conserved in all other R2 subunits.
messages: Nucleus
messages: Present with 88884 molecules/cell in log phase SD medium.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR4 is required for proper folding of RNR2 and assembly with the large subunits.

559292:YGL219C
gene id: 559292:YGL219C
uniprot id: P53083
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM34 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria (PubMed:11907266, PubMed:14981098). Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:27469264). MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10 (By similarity) (PubMed:19556461).
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane
messages: Present with 377 molecules/cell in log phase SD medium.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
messages: Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex containing the F-box protein MDM30. Ubiquitination is important for mitochondrial integrity.

559292:YKL018W
gene id: 559292:YKL018W
uniprot id: P36104
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Component of the COMPASS (Set1C) complex which consists of SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and SWD3(1). Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.
messages: Involved in mediating RNA polymerase II termination. Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.
messages: Nucleus
messages: Present with 704 molecules/cell in log phase SD medium.
messages: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: telomere

559292:YGR175C
gene id: 559292:YGR175C
uniprot id: P32476
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the squalene monooxygenase family.
messages: Endoplasmic reticulum membrane
messages: Inhibited by the allylamine antimycotic drugs.
messages: Interacts with ERG28.
messages: Lipid droplet
messages: Microsome membrane
messages: Present with 65400 molecules/cell in log phase SD medium.
messages: Squalene epoxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1743514, PubMed:8358382, PubMed:9450962). ERG1 catalyzes the epoxidation of squalene into 2,3-epoxysqualene (PubMed:1743514, PubMed:8358382, PubMed:9450962). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction …

559292:YER166W
gene id: 559292:YER166W
uniprot id: P32660
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Phosphorylated by FPK1 and KIN82.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.
messages: trans-Golgi network membrane

559292:YDL080C
gene id: 559292:YDL080C
uniprot id: Q07471
names: Biotechnology
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Fusel oils are important flavor and aroma compounds in yeast-fermented products contributing to the quality of beverages and food. In low concentration they are generally desirable, whereas high concentrations may spoil the product. By adjusting growth conditions and substrate their production is sought to be influenced.
messages: Nucleus
messages: One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) involved in amino acid catabolism. The enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids (alpha-keto-acids). In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids derived from leucine (4-methyl-2-oxopentanoate, also alpha-keto-isocaproate) and isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), whereas transaminated valine, transaminated aromatic amino acids, and pyruvate are no substrates. In analogy to the pyruvate decarboxylases the enzyme may in a side-reaction catalyze condensation (or carboligation) reactions leading to the formation of 2-hydroxy ketone, collectively called acyloins. The enzyme is also positively regulating the thiamine metabolism by a molecular mechanism that may involve thiamine concentration sensing and signal transmission.
messages: Present with 2140 molecules/cell in log phase SD medium.
messages: While genetic evidence suggests this enzyme is involved in leucine and isoleucine catabolism (PubMed:9341119, PubMed:10753893), no decarboxylase enzymatic activity could be detected in cell extracts of S.cerevisiae strains expressing the individual gene (PubMed:22904058).

559292:YHR016C
gene id: 559292:YHR016C
uniprot id: P32793
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with LSB5.
messages: Induced during sporulation.
messages: Interacts with LAS17 and SLA1.
messages: actin patch

559292:YOR061W
gene id: 559292:YOR061W
uniprot id: P19454
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Phosphorylates YTA7 during S-phase to promote transcription of histones (PubMed:22156209).
messages: Present with 4540 molecules/cell in log phase SD medium.
messages: Tetramer composed of an alpha chain, an alpha', one beta chain and one beta' chain (PubMed:12242279). Interacts with FACT subunits POB3 and SPT16 (PubMed:12242279). Interacts with NAP1 (PubMed:18086883). Interacts with YTA7 (PubMed:22156209).

559292:YGR261C
gene id: 559292:YGR261C
uniprot id: P46682
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.
messages: Present with 3570 molecules/cell in log phase SD medium.
messages: Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7) (PubMed:17873058). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:17873058).
messages: clathrin-coated vesicle membrane

559292:YLR333C
gene id: 559292:YLR333C
uniprot id: P0C0T4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: It is presumed that the precursor part of S25 is engaged in assembling of the small subunit, thus being essential in ribosome maturation.
messages: Present with 162000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS25 in yeast.

559292:YGL047W
gene id: 559292:YGL047W
uniprot id: P53178
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 28 family.
messages: Endoplasmic reticulum
messages: Heterodimer with ALG14 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.
messages: Present with 1950 molecules/cell in log phase SD medium.

559292:YGL028C
gene id: 559292:YGL028C
uniprot id: P53189
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: Involved in cell separation.
messages: Present with 22600 molecules/cell in log phase SD medium.
messages: cell wall

559292:YMR281W
gene id: 559292:YMR281W
uniprot id: P23797
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGL family.
messages: Endoplasmic reticulum membrane
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

559292:YOL009C
gene id: 559292:YOL009C
uniprot id: Q92328
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM12 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34 (PubMed:13679517, PubMed:17410204, PubMed:19556461). A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking (PubMed:28479252, PubMed:29078410). Interacts with PUF3 (By similarity) (PubMed:17210948).
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria (PubMed:19556461, PubMed:22250200). Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:19556461, PubMed:27469264). MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (By similarity) (PubMed:17410204).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: Present with 1070 molecules/cell in log phase SD medium.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

559292:YGR292W
gene id: 559292:YGR292W
uniprot id: P53341
names: Miscellaneous
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Present with 5060 molecules/cell in log phase SD medium.

559292:YDR210W-B
gene id: 559292:YDR210W-B
uniprot id: Q03494
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YDR210W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YKL156W
gene id: 559292:YKL156W
uniprot id: P35997
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 43300 molecules/cell in log phase SD medium.
messages: The N-terminus is not modified.
messages: There are 2 genes for eS27 in yeast.

559292:YMR116C
gene id: 559292:YMR116C
uniprot id: P38011
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, RACK1 serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation (PubMed:28223409). Involved in the negative regulation of translation of a specific subset of proteins (PubMed:15340087).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). RACK1 is located at the head of the SSU in the vicinity of the mRNA exit channel (PubMed:15340087, PubMed:15334071, PubMed:22096102). RACK1 interacts with the mRNA-binding protein SCP16 (PubMed:15012629). RACK1 also exists simultaneously as a homodimer in a cytosolic non-ribosome-bound form (PubMed:21704636).
messages: Cytoplasm
messages: Defective activation of the ribosome quality control (RQC) pathway.
messages: Present with 333112 molecules/cell in log phase SD medium.

559292:YHR182W
gene id: 559292:YHR182W
uniprot id: P38870
names: Miscellaneous
messages: Present with 1720 molecules/cell in log phase SD medium.

559292:YFR013W
gene id: 559292:YFR013W
uniprot id: P43596
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ISW1A complex, which at least consists of ISW1 and IOC3.
messages: Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome.
messages: Nucleus
messages: Present with 1770 molecules/cell in log phase SD medium.

559292:YJL034W
gene id: 559292:YJL034W
uniprot id: P16474
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen
messages: Interacts with EPS1, PDI1 and YOS9.
messages: Present with 337000 molecules/cell in log phase SD medium.
messages: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.
messages: The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition.

559292:YPL155C
gene id: 559292:YPL155C
uniprot id: P28743
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Might be dimeric.
messages: Present with 656 molecules/cell in log phase SD medium.
messages: Required for assembly of the mitotic spindle.
messages: cytoskeleton

559292:YDR169C
gene id: 559292:YDR169C
uniprot id: Q12427
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STB3 family.
messages: Cytoplasm
messages: Interacts with SIN3.
messages: Present with 639 molecules/cell in log phase SD medium.

559292:YJL196C
gene id: 559292:YJL196C
uniprot id: P39540
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Component of a microsomal membrane bound medium-chain fatty acid elongation system, which extends medium-chain-length fatty acids to long-chain fatty acids. Component of elongase I, which extends 12-16-carbon fatty acyl-CoAs such as lauroyl-CoA to 14-18-carbon fatty acids by incorporation of malonyl-CoA.
messages: Endoplasmic reticulum membrane
messages: Induced in wild-type cells supplemented with 14:0 fatty acids and repressed when cells are supplied with 16- and 18-carbon fatty acids.
messages: Present with 937 molecules/cell in log phase SD medium.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
messages: The HxxHH motif is essential for ELOp function in vivo and 3-keto acyl-CoA synthase activity in vitro.

559292:YDL121C
gene id: 559292:YDL121C
uniprot id: Q07541
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with PMA1 and PSG1.
messages: Lead to ER retention of PMA1.
messages: Present with 3260 molecules/cell in log phase SD medium.
messages: Specific cargo receptor protein for the plasma membrane ATPase PMA1 that acts with PSG1 to promote the transport and maturation of PMA1 (PubMed:28727280). EXP1 and PSG1 probably act sequentially to promote PMA1 sorting between the ER and the Golgi, with EXP1 promoting PMA1 export from the ER to the Golgi while PSG1 has a role in PMA1 maturation or quality control in the Golgi (PubMed:28727280).

559292:YJR048W
gene id: 559292:YJR048W
uniprot id: P00044
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: By oxygen at the level of transcription. Expression drops rapidly when the oxygen concentration falls below 0.5 uM O(2).
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of ubiquinol-cytochrome c oxidoreductase. Cytochrome c then transfers this electron to the dinuclear copper A center (CU(A)) of the COX2 subunit of cytochrome oxidase, the final protein carrier in the mitochondrial electron-transport chain. Isoform 1 (CYC1) is the predominant cytochrome c during aerobic/normoxic growth.
messages: Methylation may enhance its transport into mitochondria. Methylation occurs in fungi, plants, and some protozoa, but not in animals. The precise role of methylation at Lys-79 is unknown, but it seems to preclude pro-apoptotic activity, possibly by lowering affinity for APAF1.
messages: Mitochondrion intermembrane space
messages: Present with 7330 molecules/cell in log phase SD medium.

559292:YGL059W
gene id: 559292:YGL059W
uniprot id: P53170
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism.
messages: Interacts with PKP1.
messages: Mitochondrion matrix
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YJL061W
gene id: 559292:YJL061W
uniprot id: P40368
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC) (PubMed:11689687). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP82 is part of the NUP82 subcomplex. This subcomplex is the base for interactions with NUP116 and GLE2, with NUP42 and GLE1 and with DYN2.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved as part of the NUP82-NUP159-NSP1 subcomplex in nuclear mRNA and pre-ribosome export by acting as a linker tethering nucleoporins that are directly involved in nuclear transport to the NPC via its coiled-coil domain.
messages: Nucleus membrane
messages: Present with 9470 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YMR078C
gene id: 559292:YMR078C
uniprot id: P49956
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family. CTF18 subfamily.
messages: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. CTF18 interacts with ECO1.
messages: Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
messages: Nucleus

559292:YNL182C
gene id: 559292:YNL182C
uniprot id: P53877
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles. Interacts with RIX1.
messages: Nucleus
messages: The coiled-coil motif forms a homodimeric contact and facilitates RIX1 complex oligomerization.

559292:YDR321W
gene id: 559292:YDR321W
uniprot id: P38986
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the asparaginase 1 family.
messages: Cytoplasm
messages: Expressed constitutively.
messages: Homomer.
messages: Yeast contains two L-asparaginase isoenzymes: cytoplasmic L-asparaginase I, and cell wall L-asparaginase II.

559292:YGL010W
gene id: 559292:YGL010W
uniprot id: P25338
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPO1 family.
messages: Dioxygenase that catalyzes the alpha-oxidation of 2-hydroxy fatty acids in an iron-dependent manner (PubMed:30530523). Involved in metabolism of phytosphingosine and is required for proper endoplasmic reticulum stress response (PubMed:25345524, PubMed:30530523).
messages: Endoplasmic reticulum membrane
messages: Exhibits a defect in the metabolism that converts phytosphingosine to glycerophospholipids (PubMed:25345524). Leads to sensitivity to tunicamycin (PubMed:30530523).
messages: Present with 486 molecules/cell in log phase SD medium.

559292:YMR031C
gene id: 559292:YMR031C
uniprot id: Q05050
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EIS1 family.
messages: Cell membrane
messages: Cytoplasmic granule
messages: Present with 5570 molecules/cell in log phase SD medium.
messages: Required for normal formation of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on plasma membrane and mark the site of endocytosis.

559292:YPR105C
gene id: 559292:YPR105C
uniprot id: Q06096
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. Possesses ATPase activity.
messages: Belongs to the COG4 family.
messages: Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.
messages: Golgi apparatus membrane
messages: Present with 1620 molecules/cell in log phase SD medium.

559292:YOL060C
gene id: 559292:YOL060C
uniprot id: Q12296
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Involved in metal homeostasis and more specially in manganese sensitivity.
messages: Present with 2270 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YGR271C-A
gene id: 559292:YGR271C-A
uniprot id: Q3E705
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EFG1 family.
messages: Involved in rRNA processing. Required growth at elevated temperatures, resistance to hydroxyurea and for cell cycle progression.
messages: Present with 2840 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YPL021W
gene id: 559292:YPL021W
uniprot id: Q02710
names: Function
names: Induction
messages: Expression is regulated by the KAR4 transcription factor and reduced after pheromone induction.
messages: Involved in morphogenesis. May be involved in cell wall organization and biogenesis.

559292:YPR168W
gene id: 559292:YPR168W
uniprot id: Q06213
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. NUT2/MED10 interacts directly with SRB7/MED21.
messages: Nucleus
messages: Present with 1472 molecules/cell in log phase SD medium.

559292:Q0130
gene id: 559292:Q0130
uniprot id: P61829
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

559292:YFL024C
gene id: 559292:YFL024C
uniprot id: P43572
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enhancer of polycomb family.
messages: Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.
messages: Nucleus
messages: Present with 1110 molecules/cell in log phase SD medium.

559292:YKL110C
gene id: 559292:YKL110C
uniprot id: P34253
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KTI12 family.
messages: Cytoplasm
messages: Elongator complex-associated factor that is not a structural subunit but rather transiently contacts the complex. Regulates elongator complex gamma-toxin target (TOT) activity, resulting in G1 block by Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin), probably through regulation of the ELP1/IKI3 subunit phosphorylation state. Required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.
messages: Interacts with the elongator complex.
messages: Nucleus
messages: Present with 5260 molecules/cell in log phase SD medium.

559292:YOR220W
gene id: 559292:YOR220W
uniprot id: Q12044
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Phosphorylation of Ser-152 and Ser-160 is induced 2-fold in response to mating pheromone.
messages: Present with 967 molecules/cell in log phase SD medium.

559292:YLR160C
gene id: 559292:YLR160C
uniprot id: P0CX77
uniprot id: P0CX78
uniprot id: P0CX79
uniprot id: P0CZ17
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asparaginase 1 family.
messages: Periplasm
messages: Secreted
messages: Subject to nitrogen catabolite repression (NCR). Not found in cells grown on rich nitrogen sources like ammonia, glutamine or glutamate, but is found in cells that have been subjected to nitrogen starvation or have been grown on a poor nitrogen source such as proline.
messages: There are 4 copies for L-asparaginase 2 in yeast. The 4 identical copies ASP3-1, ASP3-2, ASP3-3 and ASP3-4 are arranged in tandem repeats located near a ribosomal DNA cluster.
messages: Yeast contains 2 L-asparaginase isoenzymes: cytoplasmic L-asparaginase I, and cell wall L-asparaginase II.

559292:YDR382W
gene id: 559292:YDR382W
uniprot id: P02400
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A (PubMed:16573688, PubMed:11431471).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 602000 molecules/cell in log phase SD medium.
messages: The 4 small acidic ribosomal P-proteins from yeast can be classified into two couples of similar but not identical sequences. Each couple (P1A/P1B and P2A/P2B) is distinctly related to one of the two acidic ribosomal P-proteins P1/P2 present in multicellular organisms.
messages: The N-terminus is not modified.

559292:YLR157C-B
gene id: 559292:YLR157C-B
uniprot id: P0C2I5
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YLR157C-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YJR111C
gene id: 559292:YJR111C
uniprot id: P47148
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PXP2 family.
messages: Impairs growth on oleate as well as on the non-fermentable carbon sources ethanol and acetate (PubMed:27392156). Leads to increased level in threonine, serine, valine, isoleucine and histidine; as well as a reduction in citrulline, tyrosine and phenylalanine (PubMed:27392156).
messages: Peroxisomal targeting signal 1 (PTS1) is a tripeptide located at the C-terminus of more than 95% of all peroxisomal matrix proteins. The prototypical PTS1 is the terminal tripeptide SKL (serine-lysine-leucine) but the consensus of PTS1 is defined as [S/A/H/C/E/P/Q/V] [K/R/H/Q] [L/F]. However, this description of the PTS1 consensus must probably be expanded beyond the terminal tripeptide.
messages: Peroxisome matrix
messages: Present with 1890 molecules/cell in log phase SD medium.
messages: Probably involved in peroxisome formation or maintenance as well as in amino acid metabolism.
messages: cytosol

559292:YOR231W
gene id: 559292:YOR231W
uniprot id: P32490
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Involved in a signal transduction pathway that play a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.
messages: Present with 1040 molecules/cell in log phase SD medium.

559292:YDR207C
gene id: 559292:YDR207C
uniprot id: P39001
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Interacts with RIM11, MCK1 and IME1.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Binds to the URS1 site (5'-AGCCGCCGA-3') and recruits the RPD3 histone deacetylase complex to the promoters to negatively regulate the expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. Recruits also the ISW2 chromatin remodeling complex to promoters in a second gene repression pathway. Associates with the master regulator of meiosis IME1 in order to activate the expression of meiosis genes. Has both a positive and negative role in regulating phospholipid biosynthesis.
messages: Nucleus
messages: Phosphorylated by RIM11 and MCK1.
messages: Present with 217 molecules/cell in log phase SD medium.

559292:YHR175W-A
gene id: 559292:YHR175W-A
uniprot id: Q3E815
names: Subcellular Location Annotation
messages: Membrane

559292:YOL108C
gene id: 559292:YOL108C
uniprot id: P13902
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus
messages: Present with 521 molecules/cell in log phase SD medium.
messages: Transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.).

559292:YBL051C
gene id: 559292:YBL051C
uniprot id: P34217
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Hyperphosphorylated in response to DNA damage by MEC1.
messages: Interacts with RAD53.
messages: Involved in normal G2/M phase transition of the mitotic cell cycle. In association with RAD53, also involved in checkpoint control in response to DNA damage.
messages: Present with 4630 molecules/cell in log phase SD medium.

559292:YOL154W
gene id: 559292:YOL154W
uniprot id: Q12512
names: Similarity
messages: Belongs to the ZPS1 family.

559292:YGR089W
gene id: 559292:YGR089W
uniprot id: P53253
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 996 molecules/cell in log phase SD medium.

559292:YBR241C
gene id: 559292:YBR241C
uniprot id: P38142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Vacuole membrane

559292:YNL029C
gene id: 559292:YNL029C
uniprot id: P53966
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Membrane
messages: Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YGL215W
gene id: 559292:YGL215W
uniprot id: P35190
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cyclin family. PCL1,2 subfamily.
messages: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Has a role in cell integrity and polarized cell growth together with the other PCL1/PCL2 cyclin family members.
messages: Forms a cyclin-CDK complex with PHO85.

559292:YMR009W
gene id: 559292:YMR009W
uniprot id: Q03677
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: By heat shock.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:15938715, PubMed:18625006). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity).
messages: Cytoplasm
messages: Nucleus

559292:YEL052W
gene id: 559292:YEL052W
uniprot id: P32317
names: Miscellaneous
names: Similarity
messages: Belongs to the AFG1 ATPase family.
messages: Present with 3570 molecules/cell in log phase SD medium.

559292:YNL282W
gene id: 559292:YNL282W
uniprot id: P53833
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POP3 family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Nucleus
messages: Present with 1360 molecules/cell in log phase SD medium.
messages: Required for processing of 5.8S rRNA (short form) at site A3 and for 5'- and 3'-processing of pre-tRNA.

559292:YBL032W
gene id: 559292:YBL032W
uniprot id: P38199
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEK2 family.
messages: Binds RNA.
messages: Cytoplasm
messages: Nucleus
messages: P-body
messages: Phosphorylated by the plasma membrane-anchored casein kinase YCK1. Phosphorylation at its C-terminus reduces its RNA-binding capacity.
messages: Present with 15600 molecules/cell in log phase SD medium.
messages: RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Required for the asymmetric localization to the daughter cell nucleus of the ASH1 transcript, coding for a specific repressor of transcription. Overexpression inhibits translation of the ASH1 transcript. Involved in the stability of transcripts such as the MTL1 mRNA. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus.
messages: telomere

559292:YJL166W
gene id: 559292:YJL166W
uniprot id: P08525
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane
messages: Present with 6140 molecules/cell in log phase SD medium.

559292:YMR065W
gene id: 559292:YMR065W
uniprot id: Q04746
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAR5 family.
messages: By mating pheromone. Expression is directly controlled by STE12 as cells respond to mating pheromone.
messages: Endoplasmic reticulum membrane
messages: Interacts with PRM3.
messages: Nucleus membrane
messages: Required for nuclear membrane fusion during karyogamy.

559292:YNL231C
gene id: 559292:YNL231C
uniprot id: P53860
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover. Regulates the release of fatty acids from lipid droplets (PubMed:24403601).
messages: Homodimer (PubMed:23519406). Apo-SFH3 forms a dimer through the hydrophobic interaction of gating helices. Binding of phosphatidylinositol leads to dissociation of the dimer into monomers in a reversible manner (PubMed:23603387).
messages: Lipid droplet
messages: Microsome membrane
messages: Present with 15361 molecules/cell in log phase SD medium.

559292:YDR030C
gene id: 559292:YDR030C
uniprot id: Q12021
names: Function
names: Subcellular Location Annotation
messages: Involved in transcription-coupled repair nucleotide excision repair (NER) of UV-induced DNA lesions.
messages: Nucleus

559292:YOL101C
gene id: 559292:YOL101C
uniprot id: Q99393
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.
messages: Belongs to the ADIPOR family.
messages: By excess zinc.
messages: Endoplasmic reticulum membrane

559292:YDL142C
gene id: 559292:YDL142C
uniprot id: Q07560
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
messages: Mitochondrion inner membrane
messages: Present with 876 molecules/cell in log phase SD medium.
messages: Ref.3 sequence was originally thought to originate from Mycobacterium phlei.

559292:YDR337W
gene id: 559292:YDR337W
uniprot id: P21771
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 6960 molecules/cell in log phase SD medium.
messages: The precursor is processed in two steps involving mitochondrial intermediate peptidase (MIP) and mitochondrial processing peptidase (MPP).

559292:YGL128C
gene id: 559292:YGL128C
uniprot id: P52868
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Belongs to the DnaJ family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures.
messages: Nucleus

559292:YML003W
gene id: 559292:YML003W
uniprot id: P0CF16
names: Caution
names: Similarity
messages: Belongs to the UPF0507 family.
messages: This is a truncated version of an UPF0507 family protein. Strain S288c has a frameshift in position 286, which disrupts the gene coding for this protein and produces two ORFs YML003W and YML002W. A contiguous sequence for a S.cerevisiae UPF0507 family protein can be found in strain YJM789 (AC A6ZM60).

559292:YMR025W
gene id: 559292:YMR025W
uniprot id: Q04368
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a COP9 signalosome-like (CSN) complex, composed of RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In the complex, it probably interacts directly with CSN9 and CSN12. Interacts also with RPN5.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response.
messages: Cytoplasm
messages: Nucleus

559292:YLR093C
gene id: 559292:YLR093C
uniprot id: Q12255
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptobrevin family.
messages: Present in a pentameric cis-SNARE complex composed of the v-SNAREs NYV1, VTI1 and YKT6, and the t-SNAREs VAM3 and VAM7 on vacuolar membranes. Interacts in trans with the cognate t-SNARE VAM3 during the docking step of homotypic vacuolar fusion. Interacts with the vacuolar transporter chaperone (VTC) complex and the vacuolar Ca(2+)-ATPase PMC1.
messages: Present with 1885 molecules/cell in log phase SD medium.
messages: Vacuolar v-SNARE required for docking. Only involved in homotypic vacuole fusion. Required for Ca(2+) efflux from the vacuolar lumen, a required signal for subsequent membrane fusion events, by inhibiting vacuolar Ca(2+)-ATPase PMC1 and promoting Ca(2+) release when forming trans-SNARE assemblies during the docking step.
messages: Vacuole membrane

559292:YOR080W
gene id: 559292:YOR080W
uniprot id: Q08496
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DIA2 family.
messages: Component of the SCF(DIA2) complex containing CDC53, SKP1, RBX1 and DIA2. Interacts with SKP1.
messages: F-box protein component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). The SCF(DIA2) complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. The SCF(DIA2) complex binds to DNA replication origins. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein. Required for invasive growth and growth under alkaline conditions.
messages: Nucleus

559292:YGR146C-A
gene id: 559292:YGR146C-A
uniprot id: Q8TGT9
names: Subcellular Location Annotation
messages: Membrane

559292:YJR031C
gene id: 559292:YJR031C
uniprot id: P47102
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in maintaining mitochondrial morphology, and in the turnover of mitochondria through mitophagy (PubMed:25190516).
messages: Endoplasmic reticulum
messages: Interacts with GMH1. Interacts (via N-terminal region) with SEC21 (via C-terminus).
messages: Membrane
messages: Mitochondrion
messages: Present with 2940 molecules/cell in log phase SD medium.
messages: The SEC7 domain is sufficient for stimulation of nucleotide exchange on myristoylated yeast ARF2.
messages: cytosol

559292:YIR041W
gene id: 559292:YIR041W
uniprot id: P40585
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YJL003W
gene id: 559292:YJL003W
uniprot id: P47081
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Mitochondrion inner membrane
messages: Present with 672 molecules/cell in log phase SD medium.
messages: Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:12446688, PubMed:28821616). May participate in merging the COX1 and COX2 assembly lines (PubMed:28821616).

559292:YHR014W
gene id: 559292:YHR014W
uniprot id: P23624
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for meiosis I segmentation (PubMed:2123556). Probably acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (PubMed:25533956).

559292:YHR003C
gene id: 559292:YHR003C
uniprot id: P38756
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesA/MoeB/ThiF family.
messages: Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
messages: Displays only the t(6)A but not the ct(6)A modification in tRNAs. Unable to sustain respiratory growth under non-fermenting conditions.
messages: Mitochondrion outer membrane
messages: Present with 8430 molecules/cell in log phase SD medium.
messages: ct(6)A is involved in promoting decoding efficiency. It is an unstable modification that can be easily hydrolyzed and converted to t(6)A during nucleoside preparation by conventional methods (PubMed:23242255).

559292:YGL163C
gene id: 559292:YGL163C
uniprot id: P32863
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Expression increases in late G1 phase compared to other phases of the cell cycle.
messages: Homohexamer (By similarity). Interacts with RAD51; RAD51-ssDNA filaments do not interact autonomously with dsDNA but do so robustly in the presence of RAD54 (PubMed:9590697, PubMed:31492866).
messages: Nucleus
messages: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:12453424). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism (PubMed:32502392). Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized (PubMed:31492866). Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (PubMed:12453424).

559292:YMR035W
gene id: 559292:YMR035W
uniprot id: P46972
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. The two catalytic IMP subunits seem to have non-overlapping substrate specificities. IMP2 substrates include nuclear encoded CYB2, mitochondrially encoded COX2 and cytochrome c1. Required for the stability of IMP1.
messages: Component of the mitochondrial inner membrane peptidase (IMP) complex which at least consists of IMP1, IMP2 and SOM1.
messages: Mitochondrion inner membrane
messages: The N-terminus is blocked.

559292:YLR121C
gene id: 559292:YLR121C
uniprot id: Q12303
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Can also be processed to start at Phe-54.
messages: Cell membrane
messages: Cleaves proteins C-terminally to mono- and paired-basic residues. Required for cell wall integrity.
messages: Positively regulated in response to cell wall perturbation.

559292:YML117W
gene id: 559292:YML117W
uniprot id: Q03735
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Displays increased sensitivity to some cell wall disrupting agents including sodium dodecyl sulfate (SDS) and calcofluor white (CFW).
messages: Expression down-regulated by cAMP.
messages: Present with 1540 molecules/cell in log phase SD medium.
messages: RNA-binding protein that associates with mRNAs encoding cell wall proteins.

559292:YGR061C
gene id: 559292:YGR061C
uniprot id: P38972
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity).
messages: Present with 40800 molecules/cell in log phase SD medium.

559292:YGL241W
gene id: 559292:YGL241W
uniprot id: P53067
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with NAP1.
messages: Present with 2940 molecules/cell in log phase SD medium.
messages: Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA-binding protein (TBP) and of histones H2A and H2B.
messages: nuclear pore complex

559292:YBL056W
gene id: 559292:YBL056W
uniprot id: P34221
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Present with 19700 molecules/cell in log phase SD medium.
messages: Responsible, together with PTC2, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.

559292:YDR093W
gene id: 559292:YDR093W
uniprot id: Q12675
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Cell membrane
messages: Phosphorylated by FPK1 and KIN82.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles.

559292:YMR119W
gene id: 559292:YMR119W
uniprot id: P54074
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the Asi complex, which contains ASI1, ASI2 and ASI3 (PubMed:25236469). Interacts directly with ASI3 (PubMed:17085444).
messages: E3 ubiquitin-protein ligase which transfers ubiquitin to substrates promoting their degradation. Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation (PubMed:25236469). Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:16735580, PubMed:17085444). Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748).
messages: Glycosylation is not required for ASI1 function.
messages: Nucleus inner membrane

559292:YOR374W
gene id: 559292:YOR374W
uniprot id: P46367
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: Mitochondrion matrix
messages: Potassium-activated aldehyde dehydrogenase involved in acetate formation during anaerobic growth on glucose.
messages: Present with 22200 molecules/cell in log phase SD medium.

559292:YDR357C
gene id: 559292:YDR357C
uniprot id: Q06333
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.
messages: Cytoplasm
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YAL042W
gene id: 559292:YAL042W
uniprot id: P39727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERGIC family.
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Phe-Tyr motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with ERV41.

559292:YGR027W-A
gene id: 559292:YGR027W-A
uniprot id: Q12085
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-GR1 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YPR069C
gene id: 559292:YPR069C
uniprot id: Q12074
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

559292:YNR066C
gene id: 559292:YNR066C
uniprot id: P53752
names: Subcellular Location Annotation
messages: Membrane

559292:YKL059C
gene id: 559292:YKL059C
uniprot id: P35728
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.
messages: Nucleus
messages: Present with 1130 molecules/cell in log phase SD medium.

559292:YLR300W
gene id: 559292:YLR300W
uniprot id: P23776
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
messages: Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme hydrolyzes both 1,3-beta- and 1,6-beta-linkages and even has beta-glucosidase activity. It could also function biosynthetically as a transglycosylase.
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: Secreted
messages: cell wall

559292:YHR155W
gene id: 559292:YHR155W
uniprot id: P38851
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIP3 family.
messages: Endoplasmic reticulum membrane
messages: Involved in mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone (PubMed:15657396, PubMed:18800175). May be involved in sterol transfer between intracellular membranes (PubMed:26001273).
messages: Mitochondrion membrane
messages: Present with 1170 molecules/cell in log phase SD medium.
messages: The VASt domain bind sterols.

559292:YNL045W
gene id: 559292:YNL045W
uniprot id: Q10740
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Inhibited by 3-(4-benzyloxyphenyl)-2-(R)-amino-1-propanethiol (thioamine) and N-hydroxy-N-(2-(S)-amino-3-(4-benzyloxyphenyl)propyl)-5-carboxypen-tanamide (hydroxamic acid). The aminopeptidase activity is stimulated by LTA(4).
messages: Nucleus
messages: Present with 5590 molecules/cell in log phase SD medium.

559292:YBR084C-A
gene id: 559292:YBR084C-A
uniprot id: P0CX82
uniprot id: P0CX83
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eL19 lies in close proximity to the binding site for eukaryotic initiation factor eIF4G (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL19 may play a role in the last stages of translation initiation, in particular subunit joining and shedding/releasing factors.
messages: Cytoplasm
messages: Present with 225000 molecules/cell in log phase SD medium.
messages: Present with 97700 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL19 in yeast.

559292:YFL009W
gene id: 559292:YFL009W
uniprot id: P07834
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with DCD53 and SKP1. Component of the SCF(CDC4) complex containing CDC53, SKP1, RBX1 and CDC4. CDC34. Interacts with CDC6 and CIC1. Interacts with SIC1; the interaction involves a SIC1 double phosphorylated motif (degron). Homodimerizes; the dimerization increases SIC1 ubiquitination in vitro.
messages: Nucleus
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition.

559292:YOR380W
gene id: 559292:YOR380W
uniprot id: Q08904
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor of multidrug resistance genes, such as PDR5. Required for growth on non-fermentable carbon sources like lactate or glycerol.

559292:YPL070W
gene id: 559292:YPL070W
uniprot id: Q02866
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Putative GTPase-activating protein.

559292:YKL174C
gene id: 559292:YKL174C
uniprot id: P36029
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Golgi apparatus membrane
messages: Required for polyamine transport. Transports putrescine effectively and spermidine less effectively.

559292:YCL025C
gene id: 559292:YCL025C
uniprot id: P25376
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source.
messages: Cell membrane
messages: Induced by transcription factors DAL81 and STP1, which are activated by a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system in response to external amino acid levels.
messages: Palmitoylated by PFA4.
messages: Present with 21100 molecules/cell in log phase SD medium.

559292:YHR021W-A
gene id: 559292:YHR021W-A
uniprot id: O13529
names: Function
names: Subcellular Location Annotation
messages: May be involved in cell wall organization and biogenesis.
messages: Membrane

559292:YDL139C
gene id: 559292:YDL139C
uniprot id: Q12334
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres.
messages: Interacts with YTA7.
messages: Nucleus
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YJR140C
gene id: 559292:YJR140C
uniprot id: P47171
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes localization of RTT106 to the HTA1-HTB1 promoter.
messages: Belongs to the HIR3 family.
messages: Chromosome
messages: Component of the HIR complex, composed of HIR1, HIR2, HIR3 and HPC2 (PubMed:16264190, PubMed:16303565). This complex may consist of one copy of HIR1 and HIR3 and two copies of HIR2 and HPC2 (PubMed:16264190). The HIR complex interacts with ASF1 (PubMed:16303565). Interacts with RTT106 (PubMed:19683497).
messages: HIR1, HIR2 and HIR3 are repressors of histone gene transcription. They are required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. Also has a role in nucleosome assembly.
messages: Nucleus
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YHR172W
gene id: 559292:YHR172W
uniprot id: P38863
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TUBGCP family.
messages: Interacts with TUB4, SPC72 and SPC98.
messages: Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB.
messages: Nucleus
messages: Present with 2230 molecules/cell in log phase SD medium.
messages: spindle pole body

559292:YDR232W
gene id: 559292:YDR232W
uniprot id: P09950
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
messages: Homodimer (PubMed:6381051). Interacts with MCX1 (PubMed:25957689).
messages: Ihnhibited by hemin.
messages: In combination with a disruption of MCX1, abrogates mitochondrial respiration.
messages: Mitochondrion matrix
messages: Present with 22600 molecules/cell in log phase SD medium.

559292:YDR358W
gene id: 559292:YDR358W
uniprot id: Q06336
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds to ARF1 and ARF2.
messages: May play a role in the regulation of membrane traffic through the trans-Golgi network.
messages: Present with 656 molecules/cell in log phase SD medium.
messages: trans-Golgi network

559292:YMR148W
gene id: 559292:YMR148W
uniprot id: P40219
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSW5 family.
messages: Involved in spore wall assembly.
messages: Membrane
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YIR039C
gene id: 559292:YIR039C
uniprot id: P40583
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Cell membrane
messages: Cleaves proteins C-terminally to mono- and paired-basic residues (By similarity). Required for cell wall integrity.
messages: N-glycosylated.

559292:YER036C
gene id: 559292:YER036C
uniprot id: P40024
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm
messages: Interacts with LSG1.
messages: Nucleus
messages: Present with 17600 molecules/cell in log phase SD medium.
messages: Stimulates 40S and 60S ribosome biogenesis.

559292:YBR142W
gene id: 559292:YBR142W
uniprot id: P38112
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. Required for the maintenance of dsRNA killer plasmid.
messages: Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
messages: Present with 981 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YGL227W
gene id: 559292:YGL227W
uniprot id: P53076
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in the GID complex. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is induced and becomes part of the complex (PubMed:22645139). Within the complex, VID30/GID1 interacts directly (via LisH domain) with GID8, and (via CTLH domain) with GID7 (PubMed:22645139).
messages: Nucleus
messages: Present with 1500 molecules/cell in log phase SD medium.
messages: Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:9737955, PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:9737955, PubMed:12686616, PubMed:22645139, PubMed:28126757).

559292:YDR072C
gene id: 559292:YDR072C
uniprot id: P38954
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Catalyzes the addition of a phosphorylinositol group onto mannosyl phosphorylinositol ceramide (MIPC) to form mannosyl diphosphorylinositol ceramide (M(IP)2C), the major sphingolipid in membranes of S.cerevisiae.
messages: Fails to accumulate M(IP)2C and instead accumulates increased amounts of the precursor mannose-inositol-P-ceramide.
messages: Golgi apparatus membrane
messages: Present with 606 molecules/cell in log phase SD medium.

559292:YFR029W
gene id: 559292:YFR029W
uniprot id: P43606
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2.
messages: Homodimer. Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex. Interacts directly with SSY1 and SSY5.
messages: Hyperphosphorylated in response to extracellular amino acids and dependent on the amino acid sensor component SSY1. Phosphorylation is positively regulated by casein kinases YCK1 and YCK2, and negatively regulated by phosphatase PP2A regulatory subunit RTS1.

559292:YKR056W
gene id: 559292:YKR056W
uniprot id: P33753
names: Caution
names: Function
names: Sequence Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.
messages: Cloning artifact which fused this protein with RHO4.
messages: It is uncertain whether Met-1, Met-38, Met-71, Met-77 or Met-82 is the initiator.
messages: Was originally thought to be an endo-exonuclease.

559292:YER177W
gene id: 559292:YER177W
uniprot id: P29311
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer (PubMed:29087344). Interacts with NTH1 (via N-terminus when phosphorylated by PKA); the interaction is direct and activates NTH1 (PubMed:29087344, PubMed:22320399). Interacts with FIN1 (PubMed:12551942).
messages: Involved in growth regulation.
messages: Present with 158000 molecules/cell in log phase SD medium.

559292:YGR220C
gene id: 559292:YGR220C
uniprot id: P31334
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 3200 molecules/cell in log phase SD medium.

559292:YGR048W
gene id: 559292:YGR048W
uniprot id: P53044
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the UFD1 family.
messages: Component of the heterotrimeric CDC48-NPL4-UFD1 ATPase complex (PubMed:16873066). The CDC48-NPL4-UFD1 ATPase complex interacts with the HRD1 ubiquitin ligase complex composed of the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873066). Interaction between the complexes is mediated by interaction between CDC48-NPL4-UFD1 complex member CDC48 and HRD1 complex member UBX2 (PubMed:16873066). Forms a complex composed of CDC48, NPL4, UFD1, DOA1, SHP1 and deubiquitinase OTU1 (PubMed:16427015). Interacts with NPL4, CDC48 and UBX2 (PubMed:11733065, PubMed:11598205, PubMed:16873066).
messages: Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD.
messages: Present with 3530 molecules/cell in log phase SD medium.

559292:YOR118W
gene id: 559292:YOR118W
uniprot id: Q12108
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC5 family.
messages: Cytoplasm
messages: May be involved in a process influencing telomere capping.
messages: Present with 2600 molecules/cell in log phase SD medium.

559292:YDR523C
gene id: 559292:YDR523C
uniprot id: P08458
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Serine/threonine protein kinase required for spore wall development.

559292:YKL067W
gene id: 559292:YKL067W
uniprot id: P36010
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homohexamer and homotetramer. Interacts with TOM40 preferentially in an unfolded, unphosphorylated form.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (PubMed:5793714). Required for repair of UV radiation- and etoposide-induced DNA damage (PubMed:18983998).
messages: Mitochondrion intermembrane space
messages: Present with 7130 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YJL151C
gene id: 559292:YJL151C
uniprot id: P14359
names: Caution
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Cytoplasmic vesicle membrane
messages: It is uncertain whether Met-1 or Met-13 is the initiator.
messages: Late endosome membrane
messages: Membrane
messages: Present with 12500 molecules/cell in log phase SD medium.
messages: Vacuole lumen

559292:YGR020C
gene id: 559292:YGR020C
uniprot id: P39111
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Present with 4050 molecules/cell in log phase SD medium.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:7929071). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:7929071).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

559292:YOR178C
gene id: 559292:YOR178C
uniprot id: P28006
names: Function
messages: Regulates the activity of glycogen synthase. It is most probably a regulatory subunit for protein phosphatase type 1.

559292:YIL110W
gene id: 559292:YIL110W
uniprot id: P40481
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL18 family.
messages: Cytoplasm
messages: Loss of Protein-histidine methylation (PubMed:24865971). Impaired early rRNA processing, resulting in a deficiency of 60S subunits and translation initiation defects (PubMed:24865971). A haploid deletion mutant leads to hypersensitivity to echinocandin-like antifungal lipopeptide caspofungin, a 1,3-beta-glucan synthase inhibitor. Deletion confers sensitivity to the synthetic tripeptide arsenical 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) (PubMed:15166135).
messages: Nucleus
messages: Protein-histidine N-methyltransferase that mediates methylation of RPL3 at 'His-243' (PubMed:20864530, PubMed:24865971). Methylates ribosome-associated RPL3, but not free RPL3, thereby regulating 60S subunit assembly (PubMed:24865971, PubMed:26826131). In addition to RPL3, mediates His methylation of other proteins (PubMed:26826131).

559292:YPL227C
gene id: 559292:YPL227C
uniprot id: P40350
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum membrane-bound UDP-glucose:dolichyl-phosphate glucosyltransferase involved in protein N-linked glycosylation.
messages: Leads to a loss of UDP-glucose:dolichyl-phosphate glucosyltransferase activity and a concomitant underglycosylation of carboxypeptidase Y.
messages: Present with 5800 molecules/cell in log phase SD medium.

559292:YIL089W
gene id: 559292:YIL089W
uniprot id: P40500
names: Subcellular Location Annotation
messages: Membrane

559292:YLR191W
gene id: 559292:YLR191W
uniprot id: P80667
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-13 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 or PEX21 receptors (PubMed:8858167, PubMed:20154681). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (PubMed:20154681). Mechanistically, PEX5 (or PEX21) receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:20154681).
messages: Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.
messages: Peroxisome membrane
messages: Present with 7900 molecules/cell in log phase SD medium.

559292:YCR014C
gene id: 559292:YCR014C
uniprot id: P25615
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-X family.
messages: During meiosis.
messages: Interacts with DNL4 subunit of the DNL4-LIF1 complex.
messages: Nucleus
messages: Repair polymerase. Involved in gap-filling in DNA nonhomologous end joining (NHEJ) required for double-strand break repair. Seems to conduct DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Preferentially acts upon short gaps formed by the alignment of linear duplexes with complementary single-strand ends. Required for filling gaps that need removal of a 5'- or 3'-terminal mismatch, however lacks nuclease activities.
messages: Stimulated by the interaction with the DNL4-LIF1 complex.

559292:YPL243W
gene id: 559292:YPL243W
uniprot id: P38687
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:7925282). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (PubMed:7925282).
messages: Cytoplasm
messages: Heterodimer with SRP72 (By similarity). SRP68-SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14 (PubMed:7925282, PubMed:11352936).
messages: Present with 6280 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YOR009W
gene id: 559292:YOR009W
uniprot id: Q12218
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall. Required for anaerobic growth.
messages: Induced during anaerobic growth. Induced by cold shock.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
messages: cell wall

559292:YDR487C
gene id: 559292:YDR487C
uniprot id: Q99258
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (Probable). Has also an unrelated function in expression of mitochondrial respiration (PubMed:12595523).
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Present with 5460 molecules/cell in log phase SD medium.
messages: S-glutathionylation of Cys-56 is reversible and dependent on the cytoplasmic isoform of glutaredoxin-2.

559292:YLL009C
gene id: 559292:YLL009C
uniprot id: Q12287
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.
messages: Mitochondrion intermembrane space

559292:YPL045W
gene id: 559292:YPL045W
uniprot id: Q03308
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS16 family.
messages: Component of the HOPS complex which is composed of PEP5, VPS16, PEP3, VPS33, VPS39 and VPS41. HOPS associates with phosphoinositides and the PX domain of VAM7. Interacts with VAM7.
messages: Cytoplasm
messages: Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. Required for growth at elevated temperatures. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
messages: Present with 1300 molecules/cell in log phase SD medium.
messages: Vacuole

559292:YNL095C
gene id: 559292:YNL095C
uniprot id: P53932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Membrane

559292:YOR197W
gene id: 559292:YOR197W
uniprot id: Q08601
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by Ca(2+) which induces self-processing and is required for the activity of the mature enzyme.
messages: Belongs to the peptidase C14B family.
messages: Cysteine protease that cleaves specifically after arginine or lysine residues (PubMed:22761449). Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging. Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells. Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa. Promotes the removal of insoluble protein aggregates during normal growth.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Present with 1400 molecules/cell in log phase SD medium.
messages: Proteolytic cleavage of the propeptide appears to occur after Arg-72 and/or Lys-86; it is not clear how the processing takes place (PubMed:11983181, PubMed:22761449). Proteolytic cleavage after Lys-331 generates a large (p20) and a small (p10) subunits (PubMed:22761449). The small subunit may be further cleaved to give rise to a shorter product starting at Gly-335 (PubMed:22761449).
messages: PubMed:19174511 reported that MCA1 may have a prion form, dubbed [MCA]. However, the same authors have later not been able to reproduce these results and retracted the paper.
messages: The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain. It targets the protein to insoluble protein aggregates.

559292:YPR054W
gene id: 559292:YPR054W
uniprot id: P41808
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-207 and Tyr-209, which activates the enzyme.
messages: Interacts with GSC2.
messages: Required for spore wall assembly. Required for proper deposition of the two outer layers of the spore wall, the chitosan and dityrosine layers. Negatively regulates GSC2, an alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Participates in a developmentally regulated signal transduction pathway that coordinates cytodifferentiation events with the transcriptional program.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

559292:YDR310C
gene id: 559292:YDR310C
uniprot id: P46676
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding protein that specifically binds the regulatory region of middle sporulation genes (MSE). Required for the repression of middle sporulation genes during vegetative growth. Represses expression via the recruitment of histone deacetylase HST1.
messages: Interacts with RFM1. This interaction is required to recruit HST1.
messages: Nucleus
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YDR346C
gene id: 559292:YDR346C
uniprot id: Q05515
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Cytoplasm
messages: Expression in mammalian cells increases survival under conditions inducing apoptosis.
messages: Nucleus
messages: Present with 45200 molecules/cell in log phase SD medium.
messages: Required for survival in response to oxidative stress. Involved in the diauxic shift.

559292:YAL032C
gene id: 559292:YAL032C
uniprot id: P28004
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with CLF1, PRP22 and PRP46. Interacts with SPP382.
messages: Belongs to the SNW family.
messages: Involved in pre-mRNA splicing. Associated with the spliceosome throughout the splicing reactions, until after the second catalytic step.
messages: Nucleus
messages: Present with 1670 molecules/cell in log phase SD medium.

559292:YOL147C
gene id: 559292:YOL147C
uniprot id: Q12462
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-11 family.
messages: Homooligomer. Interacts with PEX34.
messages: Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis.
messages: Peroxisome membrane
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YBR151W
gene id: 559292:YBR151W
uniprot id: P38281
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APD1 family.
messages: Cytoplasm
messages: Expression is controlled by the transcription factor YRR1.
messages: Nucleus
messages: Present with 2000 molecules/cell in log phase SD medium.
messages: Required for normal localization of actin patches. Involved in tolerance to sodium ions and hydrogen peroxide.

559292:YJR010W
gene id: 559292:YJR010W
uniprot id: P08536
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfate adenylyltransferase family.
messages: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
messages: Cytoplasm
messages: Expression depends on the formation of the MET4-MET28-MET31 and MET4-MET28-MET32 complexes on its 5' upstream region.
messages: Homohexamer. Dimer of trimers.
messages: Present with 1510 molecules/cell in log phase SD medium.
messages: The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.

559292:YLR367W
gene id: 559292:YLR367W
uniprot id: Q3E7Y3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 19700 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS8 in yeast.

559292:YNR026C
gene id: 559292:YNR026C
uniprot id: P11655
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. Required for autophagy.
messages: In the process of transport, SEC12 itself may migrate to the Golgi apparatus and function in subsequent transport events.
messages: Present with 6160 molecules/cell in log phase SD medium.
messages: cis-Golgi network membrane

559292:YLR455W
gene id: 559292:YLR455W
uniprot id: Q06188
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: During S phase of cell cycle.
messages: Nucleus
messages: Present with 2610 molecules/cell in log phase SD medium.

559292:YBL079W
gene id: 559292:YBL079W
uniprot id: P38181
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. During mitosis NUP53 changes its binding partner within the NPC from NUP170 to NIC96, exposing a high affinity binding site for the karyopherin PSE1, and retaining it in the NPC.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.
messages: Nucleus membrane
messages: Present with 1560 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YMR066W
gene id: 559292:YMR066W
uniprot id: Q04748
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YPL202C
gene id: 559292:YPL202C
uniprot id: Q08957
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: The transcription activation by RCS1 and AST2 depends on the mitochondrial iron-sulfur protein biosynthesis pathway.
messages: Transcription factor required for iron homeostasis and resistance to oxidative stress. With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon.

559292:YPR019W
gene id: 559292:YPR019W
uniprot id: P30665
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Required for S phase execution.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer.
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus
messages: Present with 8800 molecules/cell in log phase SD medium.

559292:YHL016C
gene id: 559292:YHL016C
uniprot id: P33413
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: By allophanate or its non-metabolized analog oxalurate. Sensitive to nitrogen catabolite repression.
messages: May polymerize.
messages: Membrane
messages: Required for active transport of urea.

559292:YOR351C
gene id: 559292:YOR351C
uniprot id: P24719
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
messages: Probable protein kinase required for meiotic recombination.

559292:YKL094W
gene id: 559292:YKL094W
uniprot id: P28321
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
messages: Converts monoacylglycerides (MAG) to free fatty acids and glycerol (PubMed:20554061). Has a strong preference for monounsaturated monoglycerides (PubMed:26869448). Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA) (PubMed:19529773). Involved in fatty acid ethyl ester (FAEE) catabolism. FAEEs are non-oxidative metabolites of ethanol that are transiently incorporated into lipid droplets (LDs). Their mobilization by LD-resident FAEE hydrolases facilitates a controlled metabolism of these potentially toxic lipid metabolites (PubMed:27036938).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Lipid droplet
messages: Mitochondrion outer membrane
messages: Present with 2140 molecules/cell in log phase SD medium.

559292:YPL248C
gene id: 559292:YPL248C
uniprot id: P04386
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Association between GAL11 and GAL4 may serve to expedite phosphorylation of GAL4.
messages: Binds DNA as a homodimer. Interacts directly with the mediator subunits GAL11/MED15 and SRB4/MED17.
messages: Nucleus
messages: Present with 166 molecules/cell in log phase SD medium.
messages: This protein is a positive regulator for the gene expression of the galactose-induced genes such as GAL1, GAL2, GAL7, GAL10, and MEL1 which code for the enzymes used to convert galactose to glucose. It recognizes a 17 base pair sequence in (5'-CGGRNNRCYNYNCNCCG-3') the upstream activating sequence (UAS-G) of these genes.
messages: the 9aaTAD motif (residues 862 to 870) is a transactivation domain present in a large number of yeast and animal transcription factors.

559292:YGR117C
gene id: 559292:YGR117C
uniprot id: P53270
names: Miscellaneous
messages: Present with 1280 molecules/cell in log phase SD medium.

559292:YGL221C
gene id: 559292:YGL221C
uniprot id: P53081
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: May interact with NGG1.
messages: Mitochondrion
messages: Present with 6000 molecules/cell in log phase SD medium.

559292:YDL137W
gene id: 559292:YDL137W
uniprot id: P19146
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus
messages: Present with 25000 molecules/cell in log phase SD medium.

559292:YNL037C
gene id: 559292:YNL037C
uniprot id: P28834
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically regulated by several compounds including AMP, NAD(+), and citrate.
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Mitochondrion
messages: Octamer of two non-identical subunits IDH1 and IDH2.
messages: Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
messages: Present with 10500 molecules/cell in log phase SD medium.

559292:YLR205C
gene id: 559292:YLR205C
uniprot id: P32339
names: Cofactor
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Binds 1 heme group.
messages: By iron deprivation.
messages: Endoplasmic reticulum membrane
messages: Plays an important role in the degradation of heme under conditions of iron deprivation.

559292:YML063W
gene id: 559292:YML063W
uniprot id: P23248
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS1 interacts directly with uS11 and eS26, which form part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 107000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS1 in yeast.
messages: Was originally thought to be MFT1, the mitochondrial fusion target protein.

559292:YLR219W
gene id: 559292:YLR219W
uniprot id: Q05812
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be involved in the control of meiotic sister-chromatid recombination.
messages: Present with 131 molecules/cell in log phase SD medium.

559292:YHR091C
gene id: 559292:YHR091C
uniprot id: P38714
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

559292:YDL188C
gene id: 559292:YDL188C
uniprot id: P23595
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2A subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Exact function not known, phosphatase 2A performs an essential cellular function.
messages: Inactivated in a complex with phosphatase methylesterase PPE1 (PP2Ai). Interacts with phosphatase 2A activator RRD2, which can reactivate PP2Ai by dissociating the catalytic subunit from the complex. Interacts with TAP42.
messages: Present with 4110 molecules/cell in log phase SD medium.
messages: Reversibly methyl esterified on Leu-377 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.

559292:YPL193W
gene id: 559292:YPL193W
uniprot id: Q08932
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Involved in a late nucleoplasmic step of 60S ribosomal subunit assembly.
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YIL074C
gene id: 559292:YIL074C
uniprot id: P40510
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
messages: Present with 2010 molecules/cell in log phase SD medium.

559292:YEL016C
gene id: 559292:YEL016C
uniprot id: P39997
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated as part of the catalytic cycle of phosphodiesterase/pyrophosphatase activity.
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and PHO5.
messages: Membrane
messages: Up-regulated during phosphate starvation.

559292:YDR486C
gene id: 559292:YDR486C
uniprot id: Q03390
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome membrane
messages: Has a role in a late stage of multivesicular body (MVB) formation. Can stimulate VPS4 ATPase activity via VTA1.
messages: Interacts with VTA1; the interaction occurs at he endosomal membrane.
messages: Present with 2110 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YJL122W
gene id: 559292:YJL122W
uniprot id: P47019
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALB1 family.
messages: Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles. Interacts directly with ARX1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 4780 molecules/cell in log phase SD medium.
messages: With ARX1, involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.

559292:YER133W
gene id: 559292:YER133W
uniprot id: P32598
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.
messages: Cytoplasm
messages: Involved in control of glycogen metabolism, meiosis, translation, chromosome segregation, cell polarity and G2/M cell cycle progression. PP1 may act in opposition to the IPL1 protein kinase in regulating chromosome segregation by dephosphorylating H3S10ph. The BUD14-GLC7 complex is necessary to regulate microtubule dynamics at the cortex and may function as a specific activator of the dynein complex.
messages: Nucleus
messages: Present with 14600 molecules/cell in log phase SD medium.
messages: Probably complexed with regulatory or targeting subunits (PubMed:12819204). Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1 (PubMed:12819204). Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2 (PubMed:12819204). Interacts with BUD14 (PubMed:12477789, PubMed:16107882). Interacts with YPI1 (PubMed:14690591). Interacts with SCD5 (via KKVRF motif) (PubMed:12356757).

559292:YHR084W
gene id: 559292:YHR084W
uniprot id: P13574
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STE12 transcription factor family.
messages: Binds to the DNA sequence mediating pheromone induction (called the pheromone response element = PRE) which is found in the upstream control region of several a-, alpha- and haploid-specific genes. Involved in mating of haploids and in pseudohyphae formation in diploids.
messages: Interacts with mating-type protein ALPHA1.
messages: Nucleus
messages: Phosphorylated by the STE7, STE11 and STE20 kinases.
messages: Present with 1920 molecules/cell in log phase SD medium.
messages: The DNA-binding domain seems to be involved in the suppression of pseudohyphae formation under nitrogen-rich conditions and in haploids. This region is also involved in the regulation of budding pattern of haploids.

559292:YPR065W
gene id: 559292:YPR065W
uniprot id: P25042
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: By heme.
messages: Nucleus
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Transcription factor that represses the expression of HEM13, COX5B, ANB1, CYC7 or AAC3 (hypoxic function). Binds to the DNA sequence 5'-RRRTAACAAGAG-3'.

559292:YER052C
gene id: 559292:YER052C
uniprot id: P10869
names: Miscellaneous
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Present with 48100 molecules/cell in log phase SD medium.

559292:YCR092C
gene id: 559292:YCR092C
uniprot id: P25336
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
messages: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with either the MutL alpha or MutL beta heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. MutS beta also has a role in regulation of heteroduplex formation during mitotic and meiotic recombination. MutS beta binds to DNA flap structures predicted to form during recombination, and is required for 3' non-homologous tail removal (NHTR). MutS beta-binding alters the DNA conformation of its substrate at the ds/ssDNA junction and may facilitate its recognition and/or cleavage by the downstream nucleotide excision repair (NER) RAD1-RAD10 endonuclease. ATP binding and hydrolysis play a pivotal role in MMR and NHTR.
messages: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with either MutL alpha (MLH1-PMS1) or MutL beta (MLH1-MLH3). MutS beta interacts with proliferating cell nuclear antigen (PCNA/POL30). Interacts with SAW1.
messages: Nucleus
messages: Present with 736 molecules/cell in log phase SD medium.
messages: The PIP box serves as a PCNA(POL30)-recognition and -binding motif.

559292:YJR069C
gene id: 559292:YJR069C
uniprot id: P47119
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 3490 molecules/cell in log phase SD medium.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

559292:YOR304W
gene id: 559292:YOR304W
uniprot id: Q08773
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex.
messages: Component of the ISW2 complex, which at least consists of ISW2, ITC1, DLS1 and DPB4. May form a stable subcomplex with ITC1.
messages: Nucleus
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:Q0075
gene id: 559292:Q0075
uniprot id: Q9ZZX0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAGLIDADG endonuclease family.
messages: Endonuclease aI5 beta (group I intron) is encoded within an intron of the mitochondrial COX1 gene. Splicing from COX1 requires PET54, MRS1, SUV3 and MSS18. Translational initiation codon is predicted to be ATA rather than ATG.
messages: Mitochondrial DNA endonuclease involved in intron homing.
messages: Mitochondrion

559292:YDR383C
gene id: 559292:YDR383C
uniprot id: Q12493
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKP1 family.
messages: Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:22561346). NKP1 interacts directly with OKP1 and AME1 (By similarity).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Nucleus
messages: kinetochore

559292:YGL006W
gene id: 559292:YGL006W
uniprot id: P38929
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Present with 98 molecules/cell in log phase SD medium.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.
messages: Vacuole membrane

559292:YML108W
gene id: 559292:YML108W
uniprot id: Q03759
names: Miscellaneous
messages: Present with 2610 molecules/cell in log phase SD medium.

559292:YDL126C
gene id: 559292:YDL126C
uniprot id: P25694
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates (PubMed:21454554, PubMed:31445887). By recruiting and promoting the degradation of ubiquitinated proteins, plays a role in the ubiquitin fusion degradation (UFD) pathway (PubMed:16428438). Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway which mediates the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:11813000, PubMed:11740563, PubMed:11847109, PubMed:21148305). Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1 (PubMed:11847109, PubMed:11733065). Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD (PubMed:11847109). Regulates ubiquitin-mediated mitochondria protein degradation (PubMed:21070972, PubMed:27044889). Involved in spindle disassembly probably by promoting the degradation of spindle assembly factors ASE1 and CDC5 at the end of mitosis (PubMed:14636562). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123, PubMed:24261871). CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel (PubMed:23178123, PubMed:24261871). Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation (PubMed:20508643). Component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control (PubMed:29355480). Substrate initiall…
messages: Belongs to the AAA ATPase family.
messages: Component of the heterotrimeric CDC48-NPL4-UFD1 ATPase complex (PubMed:16873066). The CDC48-NPL4-UFD1 ATPase complex interacts with the HRD1 ubiquitin ligase complex composed of the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873066). Interaction between the complexes is mediated by interaction between CDC48-NPL4-UFD1 complex member CDC48 and HRD1 complex member UBX2 (PubMed:16873066). Forms a complex composed of CDC48, NPL4, UFD1, UFD2 and SHP1 (PubMed:16427015). Forms a complex composed of CDC48, NPL4, UFD1, DOA1, SHP1 and deubiquitinase OTU1; within the complex interacts with DOA1/UFD3 and OTU1 to prevent multiubiquitination of substrates (PubMed:16427015). Interacts with UFD2, to add further ubiquitin moieties; the interaction with UFD2 is prevented by DOA1/UFD3 (PubMed:16427015). Forms a complex composed of CDC48, DOA1, deubiquitinase UBP3 and probably BRE5; within the complex interacts with DOA1 and UBP3 (PubMed:20508643). Interacts (via C-terminus) with DOA1 (via PUL domain); the interaction is direct (PubMed:16428438, PubMed:19805280, PubMed:27044889). Interacts with NPL4 (PubMed:11733065, PubMed:11598205, PubMed:31249134). Interacts with SHP1/UBX1, UBX2, UBX3, UBX4, UBX5, UBX6 and UBX7 (PubMed:15258615, PubMed:31249134). Interacts with VMS1; the interaction recruits CDC48 to the mitochondria in response to mitochondrial stress (PubMed:21070972, PubMed:21148305). Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase RKR1/LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors (PubMed:23178123, PubMed:23479637). RQC forms a stable complex with 60S ribosomal subunits (PubMed:23178123, PubMed:23479637). Interacts with ASE1 and CDC5; the interaction is likely to result in their degradation (PubMed:14636562). Component of the DSCc E3 ligase complexes composed of at least TUL1, DSC2, DSC3, UBX3, CDC48 as well as VLD1 for the vac…
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Microsome
messages: Present with 78400 molecules/cell in log phase SD medium.
messages: The first ATP-binding region has low ATPase activity (By similarity). The second ATP-binding region is responsible for ATPase activity (By similarity). ATP binding to the first ATP-binding region induces intrinsic activity of the second ATP-binding region (PubMed:21454554). While ATP binding to the first ATP-binding region appears to prevent ATP hydrolysis by the second ATP-binding region, ADP-binding to first region promotes the coordinate and cooperative ATPase cycle of the second ATP-binding region (By similarity). ATP binding to the first ATP-binding region induces a conformational change, promoting the rotation of the first ATP-binding region relative to the second ATP-binding region in the hexamer (By similarity).

559292:YDR003W
gene id: 559292:YDR003W
uniprot id: Q03446
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 1230 molecules/cell in log phase SD medium.
messages: To yeast YBR005W.

559292:YGR282C
gene id: 559292:YGR282C
uniprot id: P15703
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.
messages: Present with 45000 molecules/cell in log phase SD medium.
messages: This protein strongly binds to glucan and chitin.
messages: cell wall

559292:YKL201C
gene id: 559292:YKL201C
uniprot id: P36044
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: May function as a positive regulator for mannosylphosphate transferase. Is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.
messages: Membrane
messages: To yeast YJR061w.

559292:YNL315C
gene id: 559292:YNL315C
uniprot id: P32453
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Essential for the assembly of the mitochondrial F1-F0 complex. May interact with the alpha and/or beta subunits of F1-ATPase.
messages: Mitochondrion
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YGR023W
gene id: 559292:YGR023W
uniprot id: P53214
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MID2 like cell wall stress sensor family.
messages: Involved in cell integrity signaling during vegetative growth at elevated temperature. Acts positively on the PKC1-MAPK pathway. Cell membrane sensor of oxidative stress in the cell integrity pathway upstream of PKC1. Required to transmit the oxidative signal to SLT2 and to restore the correct actin organization following oxidative stress. Multicopy suppressor of 1,3-beta-glucan synthase (GS) mutation. Also suppresses RGD1 null mutations.
messages: Membrane

559292:YGL119W
gene id: 559292:YGL119W
uniprot id: P27697
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Able to autophosphorylate in cis in vitro. This activity may not be relevant in vivo and only reflects in vitro conditions. Probably does not act as a protein kinase as it is unable to act in trans (PubMed:27499294).
messages: Adopts an atypical protein kinase-like fold: while it adopts a core fold similar to that of well-characterized protein kinase-like domains. The KxGQ motif completely occludes the typical substrate binding pocket. Nucleotide-binding opens the substrate binding pocket and flips the active site from inside the hydrophobic core into a catalytically competent, solvent-exposed posture.
messages: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:27499294). Affects the molecular organization and function of COQ3, possibly through kinase activity towards COQ3, COQ5 and/or COQ7 (PubMed:11279158, PubMed:15063807, PubMed:1648478, PubMed:18801050, PubMed:19002377, PubMed:21296186, PubMed:9210471, PubMed:9266513, PubMed:25498144). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity).
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Decreases COQ3 O-methyltransferase activity.
messages: Forms homopolymers. Predominantly associated with a complex of about 500 kDa.
messages: Mitochondrion inner membrane
messages: Present with 952 molecules/cell in log phase SD medium.
messages: Was originally (PubMed:1648478) isolated as a multicopy suppressor of a yeast strain harboring a mutation in a cytochrome b translational activator (cbs2-223). But more recently it has been shown (PubMed:15063807) that a tRNA(Trp) gene located downstream of COQ8 mediates suppression of the cbs2-223 mutation. The inability of COQ8 to suppress the cbs2-223 allele in multicopy indicates it may not be a chaperone as previously reported.

559292:YMR224C
gene id: 559292:YMR224C
uniprot id: P32829
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Forms a complex with RAD50 and XRS2.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus
messages: Present with 432 molecules/cell in log phase SD medium.

559292:YGR227W
gene id: 559292:YGR227W
uniprot id: P50076
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

559292:YLR350W
gene id: 559292:YLR350W
uniprot id: Q06144
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis. Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity.
messages: Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3.
messages: Endoplasmic reticulum membrane
messages: Phosphorylated in case of disruption of sphingolipid synthesis. Phosphorylation regulates inhibitory activity of serine palmitoyltransferases (LCB1 and LCB2).
messages: Present with 5240 molecules/cell in log phase SD medium.

559292:YDR170W-A
gene id: 559292:YDR170W-A
uniprot id: Q03964
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YDL030W
gene id: 559292:YDL030W
uniprot id: P19736
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Belongs to the SF3A3 family.
messages: Nucleus
messages: Present with 3920 molecules/cell in log phase SD medium.
messages: mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.

559292:YML105C
gene id: 559292:YML105C
uniprot id: P29478
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Fungal signal recognition particle (SRP) complex consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.
messages: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SEC65 is required for SRP integrity.

559292:YMR310C
gene id: 559292:YMR310C
uniprot id: Q04867
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.
messages: Nucleus
messages: Present with 2540 molecules/cell in log phase SD medium.

559292:YIL030C
gene id: 559292:YIL030C
uniprot id: P40318
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DOA10/MARCH6 family.
messages: Component of the DOA10 ubiquitin ligase complex which contains E3 ligase SSM4/DOA10 and CDC48-binding protein UBX2/SEL1. The DOA10 complex interacts with the heterotrimeric CDC48-NPL4-UFD1 ATPase complex which is recruited by UBX2/SEL1 via its interaction with CDC48. Interacts with its associated ubiquitin conjugating enzymes UBC6 and UBC7 with its membrane anchor CUE1. Interacts with PEX29.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC6 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation (PubMed:11641273, PubMed:16179952, PubMed:16437165, PubMed:16873066, PubMed:17051211, PubMed:18812321, PubMed:20110468). Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC) (PubMed:11641273, PubMed:16179952, PubMed:16437165, PubMed:16873066, PubMed:17051211, PubMed:18812321, PubMed:20110468). Component of the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains (PubMed:16873066). ERAD-C substrates are ubiquitinated through DOA10 in conjunction with the E2 ubiquitin-conjugating enzymes UBC6 and UBC7-CUE1 (PubMed:11641273, PubMed:16179952, PubMed:16437165, PubMed:16873066, PubMed:17051211, PubMed:18812321, PubMed:20110468). Ubiquitinated substrates are then removed to the cytosol via the action of the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex and targeted to the proteasome (PubMed:11641273, PubMed:16179952, PubMed:16437165, PubMed:16873066, PubMed:17051211, PubMed:18812321, PubMed:20110468). Also recognizes the N-terminally acetylated residue of proteins as degradation signal (degron) (PubMed:20110468). N-terminally acetylated target proteins include MATALPHA2, TBF1, SLK19, YMR090W, HIS3, HSP104, UBP6 and ARO8 (PubMed:20110468). Catalyzes ubiquitination of mislocalized tail-anchored proteins that are extracted from the mitochondrion membrane by MSP1: following extraction, mistargeted proteins are transferred to the endoplasmic reticulum, where they are ubiquitinated by DOA10 and degraded by the proteasome (PubMed:31445887).
messages: Endoplasmic reticulum membrane
messages: Nucleus inner membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

559292:YGR207C
gene id: 559292:YGR207C
uniprot id: P42940
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Binds 1 AMP per subunit.
messages: Binds 1 FAD per dimer.
messages: Displays higher growth rate and higher sensitivity to superoxide and heat stress, on nonfermentable carbon sources. Leads to decreased intracellular oxidation upon heat shock. Under conditions of mitochondrial perturbation by antimycin A, displays increased peroxisomal proliferation.
messages: Heterodimer of an alpha and a beta subunit (By similarity). Interacts with YFH1.
messages: Mitochondrion matrix
messages: Present with 2400 molecules/cell in log phase SD medium.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).

559292:YJL144W
gene id: 559292:YJL144W
uniprot id: P47009
names: Miscellaneous
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YKL017C
gene id: 559292:YKL017C
uniprot id: P34243
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the hexameric DNA polymerase alpha.
messages: Belongs to the DNA2/NAM7 helicase family.
messages: By heat shock.
messages: Cytoplasm
messages: DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication.
messages: Nucleus
messages: Present with 1040 molecules/cell in log phase SD medium.

559292:YMR238W
gene id: 559292:YMR238W
uniprot id: Q05031
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 76 family.
messages: Cell membrane
messages: N-glycosylated.
messages: Present with 2950 molecules/cell in log phase SD medium.
messages: Required for normal synthesis of the cell wall.

559292:YJL115W
gene id: 559292:YJL115W
uniprot id: P32447
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Expression peaks in S-phase (at the RNA level).
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:16936140, PubMed:16678113, PubMed:16407267, PubMed:16039596, PubMed:15891116, PubMed:16303565, PubMed:15766286, PubMed:15542829, PubMed:15175160, PubMed:15452122, PubMed:15071494, PubMed:11856374, PubMed:11404324, PubMed:11331602, PubMed:11172707, PubMed:14680630). Facilitates histone deposition through both replication-dependent and replication-independent chromatin assembly pathways (PubMed:14585955, PubMed:16678113, PubMed:15632066). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with the HIR complex to promote replication-independent chromatin assembly, which may occur during transcription and DNA repair (PubMed:16501045, PubMed:16582440, PubMed:16141196, PubMed:16143623, PubMed:16020781, PubMed:15821127, PubMed:16303565, PubMed:15542840, PubMed:12093919, PubMed:11756556, PubMed:11404324, PubMed:11731480, PubMed:11731479, PubMed:11412995, PubMed:10591219). May be required for the maintenance of a subset of replication elongation factors, including DNA polymerase epsilon, the RFC complex and PCNA, at stalled replication forks (PubMed:15901673, PubMed:11412995). Also required for RTT109-dependent acetylation of histone H3 on 'Lys-9' and 'Lys-56' (PubMed:17320445, PubMed:17107956, PubMed:17046836, PubMed:16815704, PubMed:16627621, PubMed:15840725, PubMed:21256037). Promotion of RTT109-mediated histone H3 'Lys-56' acetylation is dependent on interactions with histone H3 pre-acetylated on 'Lys-14' (PubMed:31194870).
messages: Interacts with histone H3/H4 heterodimers via both histone H3 and histone H4 (PubMed:11172707, PubMed:11412995, PubMed:11856374, PubMed:11756556, PubMed:12626510, PubMed:16303565, PubMed:15840725, PubMed:16582440, PubMed:14680630, PubMed:17081973, PubMed:31387991, PubMed:29300933, PubMed:27036862). Binds with higher affinity to H3/H4 heterodimers where histone H3 has been pre-acetylated on 'Lys-14' (PubMed:31194870). Interacts with RAD53 and this may impair interaction with histones and chromatin assembly; the interaction is reduced upon activation of DNA damage or replication checkpoints which in turn promotes histone binding and chromatin assembly (PubMed:11331602, PubMed:12851493, PubMed:12917350, PubMed:16303565, PubMed:16020781, PubMed:14680630). Interacts with the CAC2 subunit of chromatin assembly factor 1 (CAF-1) (PubMed:11756556). Interacts with the HIR1, HIR2, HIR3 and HPC2 subunits of the HIR complex (PubMed:11404324, PubMed:11412995, PubMed:16303565). Interacts with the RFC1, RFC2, RFC3, RFC4 and RFC5 subunits of the replication factor C (RF-C/RFC) complex; which may recruit this protein to DNA (PubMed:15901673). Interacts with the SAS2, SAS4 and SAS5 subunits of the SAS/SAS-I complex (PubMed:11731479, PubMed:11731480). Interacts with the BDF1, BDF2, SPT15, TAF1 and TAF7 subunits of the TFIID complex (PubMed:12093919). Interacts with RTT109 and VPS75; the interaction with RTT109 is direct (PubMed:29300933, PubMed:31387991, PubMed:17320445).
messages: Nucleus
messages: Present with 6230 molecules/cell in log phase SD medium.

559292:YLR454W
gene id: 559292:YLR454W
uniprot id: Q06179
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: Present with 1360 molecules/cell in log phase SD medium.
messages: Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution.

559292:YNR018W
gene id: 559292:YNR018W
uniprot id: P53721
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor that plays a role in the assembly of the respiratory chain supercomplexes (SCs) composed of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV). May be required for late-stage assembly of the COX12 and COX13 subunits (PubMed:22342701, PubMed:22310663). Required for the generation and maintenance of a normal proton motive force (PMF) across the inner mitochondrial membrane (IMM) by preventing proton leakage through an inactive population of CIV that accumulates when RCF1 and/or RCF2 proteins are absent (PubMed:30683696, PubMed:31591265).
messages: Associates with a subpopulation of the cytochrome bc1-cytochrome c oxidase supercomplexes (PubMed:19750512, PubMed:22342701, PubMed:22310663). Associates in substoichiometric amounts with complex IV (PubMed:22310663). Interacts with COX3 (PubMed:22310663).
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion membrane
messages: Present with 12000 molecules/cell in log phase SD medium.

559292:YNL039W
gene id: 559292:YNL039W
uniprot id: P46678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFC5 family.
messages: General activator of RNA polymerase III transcription.
messages: Nucleus
messages: TFIIIB comprises the TATA-binding protein (TBP), the B-related factor (BRF) and the B'' component (BDP1). Interacts with TFC4.

559292:YMR235C
gene id: 559292:YMR235C
uniprot id: P11745
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA1 family.
messages: Causes conditional lethality. Strains bearing this mutation do not grow at temperatures exceeding 30 degrees Celsius.
messages: Cytoplasm
messages: GTPase activator for the nuclear Ras-related regulatory protein GSP1 (Ran), converting it to the putatively inactive GDP-bound state.
messages: Present with 52200 molecules/cell in log phase SD medium.

559292:YIL131C
gene id: 559292:YIL131C
uniprot id: P40466
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Causes only a modest decline in CLB2 cluster genes expression, but this expression is abolished when both FKH1 and FKH2 are deleted (PubMed:10959837). Leads to a defect in silencing HMRa (PubMed:10747051). Causes a form of yeast pseudohyphal growth, when FKH2 is also deleted (PubMed:10747051). Affects cell-cycle progression and CLB2 mRNA expression (PubMed:10747051). Leads to defect in pre-mRNA 3' end formation during transcription of targeted genes (PubMed:12702877).
messages: Interacts (via FHA domain) with ECM30, GLN3, URE2, MPH1 AND FDO1 (PubMed:27257873). Interacts with the origin recognition complex (ORC) composed of ORC1 to ORC6 (PubMed:22265405).
messages: Nucleus
messages: Present with 1720 molecules/cell in log phase SD medium.
messages: The phosphothreonine-binding FHA domain is required for the interaction with MPH1 and controlling recombination donor preference during mating-type switching.
messages: Transcription factor that regulates the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle (PubMed:10959837, PubMed:10894548, PubMed:10894549, PubMed:11562353, PubMed:12702877, PubMed:17283050, PubMed:24504085). The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20 as well as SWI5 and ACE2, transcription factors required for the subsequent temporal wave of cell cycle regulated gene expression in the M/G1 phase interval (PubMed:10959837, PubMed:10894548, PubMed:11562353). Involved in HMRa silencing (PubMed:10747051). FKH1 and FKH2 associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing (PubMed:12702877). Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation (PubMed:22438832). FKH1 and FKH2 function also in controlling yeast cell morphology by preventing preudohyphal growth (PubMed:10747051, PubMed:10894548). Acts as a rate-limiting replication origin activator via its interactin with the origin recognition complex (ORC) (PubMed:22265405, PubMed:26728715). Plays a transcription-independent role in recombination donor preference during mating-type switching through binding to the recombination enhancer (RE), a 700-bp cis-acting element that controls recombination along the left arm of chromosome III (PubMed:12183363, PubMed:16809780, PubMed:22496671, PubMed:27257873).
messages: cytosol

559292:YKR095W-A
gene id: 559292:YKR095W-A
uniprot id: Q3E833
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTAG/PCC1 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. PCC1 functions as a dimerization module for the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Nucleus
messages: telomere

559292:YDR377W
gene id: 559292:YDR377W
uniprot id: Q06405
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase F chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 14600 molecules/cell in log phase SD medium.

559292:YLR182W
gene id: 559292:YLR182W
uniprot id: P09959
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription complex MCB-binding factor (MBF) composed of SWI6 and MBP1. Component of the transcription complex SCB-binding factor (SBF) composed of SWI6 and SWI4. Interacts with MSA1 and STB1.
messages: Cytoplasm
messages: Nucleus
messages: Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
messages: Phosphorylated by CDC28 and dephosphorylated by CDC14.
messages: Present with 3340 molecules/cell in log phase SD medium.

559292:YKL126W
gene id: 559292:YKL126W
uniprot id: P12688
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by phytosphingosine (PHS), a sphingoid long chain base. Activated by PKH1 phosphorylation.
messages: Autophosphorylated. Autophosphorylation is stimulated by PHS. Phosphorylated by PKH1. PHS stimulates phosphorylation by PKH1. The N-terminal half is phosphorylated by FPK1.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Plays an essential role in the proliferation of yeast cells. Involved in a signaling pathway, required for optimal cell wall integrity, that acts in parallel with the PKC1-SLT2-dependent pathway. Downstream kinase in the sphingolipid-mediated signaling pathway. Its phosphorylation is regulated by the intracellular sphingolipid concentration. Cooperates with SLI1 in mediating resistance to the sphingolipid biosynthesis inhibitor drug myriocin (ISP-1). Its kinase activity is essential for the resistance. Required for both receptor-mediated and fluid-phase endocytosis, but is not necessary for receptor phosphorylation or ubiquitination. Necessary for the internalization of plasma membrane proteins carrying different types of internalization signals. Acts downstream of the PKH kinases to control endocytosis by phosphorylating components of the endocytic machinery. Phosphorylation of residue Thr-504 in the activation loop is essential for activity. phosphorylates and down-regulates flippase activator FPK1.
messages: Present with 2950 molecules/cell in log phase SD medium.

559292:YOR171C
gene id: 559292:YOR171C
uniprot id: Q12246
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively (PubMed:9677363, PubMed:11102354, PubMed:11795842, PubMed:16141212, PubMed:25345524). Involved in the biosynthesis of sphingolipids and ceramides (PubMed:12493772). Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest (PubMed:11056159). Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling (PubMed:11278643). Involved in heat-stress resistance (PubMed:11967828).
messages: Cell membrane
messages: Completely abolishes the conversion of phytosphingosin to glycerophospholipid.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Palmitoylated by palmitoyltransferase AKR1; this anchors the protein to the plasma membrane.
messages: Phosphorylated by the cyclin-CDKs PCL1-PHO85 and PCL2-PHO85. Phosphorylation is a prerequisite to ubiquitination. The phosphorylation level depends on sterol composition and may also be involved in subcellular location (PubMed:16141212).
messages: Present with 2840 molecules/cell in log phase SD medium.
messages: Ubiquitinated. The ubiquitination leads to degradation in the vacuole.

559292:YDL060W
gene id: 559292:YDL060W
uniprot id: Q07381
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
messages: Cytoplasm
messages: Interacts with RIO2.
messages: Present with 1390 molecules/cell in log phase SD medium.
messages: Required for 40S ribosomal subunit synthesis. Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunitshifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein.
messages: nucleolus

559292:YPL212C
gene id: 559292:YPL212C
uniprot id: Q12211
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Binds 1 zinc ion per subunit.
messages: Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr) (PubMed:9671058, PubMed:10356324, PubMed:25219674). Catalyzes pseudouridylation at position 44 in U2 snRNA (PubMed:25219674). Also catalyzes pseudouridylation of mRNAs (PubMed:25219674, PubMed:31477916).
messages: Nucleus
messages: Present with 8130 molecules/cell in log phase SD medium.

559292:YKR029C
gene id: 559292:YKR029C
uniprot id: P36124
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the SET3 family.
messages: Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.
messages: Present with 623 molecules/cell in log phase SD medium.
messages: Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity.

559292:YLR438C-A
gene id: 559292:YLR438C-A
uniprot id: P57743
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM3 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. LSM3, probably in a complex that contains LSM2-LSM7 but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA. LSM3 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a doughnut shape. The LSm subunits are arranged in the order LSM1, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. Except for LSM1, where a C-terminal helix crosses the ring structure to form additional interactions with LSM3 and LSM6, each subunit interacts only with its two neighboring subunits. The LSM1-LSM7 complex interacts with PAT1; within the complex PAT1 has direct interactions with LSM2 and LSM3. Component of the heptameric LSM2-LSM8 complex that forms a seven-membered ring structure with a doughnut shape; an RNA strand can pass through the hole in the center of the ring structure. The LSm subunits are arranged in the order LSM8, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. LSM2-LSM8 associates with PAT1 and XRN1. A complex comprising LSM2-LSM7 without LSM1 or LSM8 may exist. Likewise, LSM2 and LSM3 can assemble into a doughnut structure that binds PAT1 (in vitro). Besides, LSM3 can form a homooctameric ring (in vitro). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 7060 molecules/cell in log phase SD medium.

559292:YOL080C
gene id: 559292:YOL080C
uniprot id: Q08237
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REXO4 family.
messages: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
messages: Nucleus
messages: Present with 4280 molecules/cell in log phase SD medium.

559292:YOR388C
gene id: 559292:YOR388C
uniprot id: Q08911
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms (PubMed:9178506, PubMed:12144528, PubMed:11921099). Has a role in the detoxification of exogenous formate in non-methylotrophic organisms (PubMed:11921099).
messages: Cytoplasm
messages: Homodimer.
messages: Induced by formate.

559292:YMR072W
gene id: 559292:YMR072W
uniprot id: Q02486
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Has a temperature-sensitive growth defect in glucose-rich medium, with slower growth and smaller colonies at 37 degrees Celsius but not 30 degrees Celsius; the phenotype is suppressed by overexpression of YHM2.
messages: Mitochondrion
messages: Nucleus
messages: Present with 3810 molecules/cell in log phase SD medium.
messages: Specific binding to the autonomously replicating sequence 1 (ARS1). Interaction with regulatory regions: probably involved in compacting the mitochondrial genome. It might play a positive role in gene expression and replication.

559292:YNL016W
gene id: 559292:YNL016W
uniprot id: P32588
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be associated with hnRNA within the nucleus and remains associated during nucleocytoplasmic mRNA transport, once the proteins are in the cytoplasm, disassembly of PUB1-RNA complexes may occur prior to PAB1 binding and formation of a translationally competent RNP complex. Binds to polyadenylated RNA; prefers to bind poly(rU); binds to T-rich single-stranded DNA.
messages: Nucleus
messages: P-body
messages: Present with 49600 molecules/cell in log phase SD medium.
messages: Stress granule

559292:YGR099W
gene id: 559292:YGR099W
uniprot id: P53038
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TEL2 family.
messages: Component of the TTT complex composed of TEL2, TTI1 and TTI2. Interacts with TTI1 and TTI2.
messages: Nucleus
messages: Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.
messages: Present with 638 molecules/cell in log phase SD medium.
messages: telomere

559292:YLL025W
gene id: 559292:YLL025W
uniprot id: Q12370
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YLL027W
gene id: 559292:YLL027W
uniprot id: Q07821
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
messages: Mitochondrion matrix
messages: Present with 125 molecules/cell in log phase SD medium.

559292:YNL172W
gene id: 559292:YNL172W
uniprot id: P53886
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC1 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: Cytoplasm
messages: Nucleus
messages: Present with 178 molecules/cell in log phase SD medium.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1. APC1 interacts directly with MND2.
messages: spindle pole

559292:YGR171C
gene id: 559292:YGR171C
uniprot id: P22438
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of methionine to tRNA(Met) in the mitochondrion.
messages: Mitochondrion matrix
messages: Present with 3120 molecules/cell in log phase SD medium.

559292:YBR041W
gene id: 559292:YBR041W
uniprot id: P38225
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:9079682, PubMed:11330068, PubMed:9988704, PubMed:12052836, PubMed:12601005). The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities (PubMed:12052836). Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane (PubMed:22493507).
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Cell membrane
messages: Interacts with fatty acyl-CoA synthetases FAA1 and FAA4.
messages: Lipid droplet
messages: Peroxisome
messages: Peroxisome membrane
messages: Present with 16900 molecules/cell in log phase SD medium.
messages: The FACS motif is required for catalytic activity and substrate specificity.

559292:YGR174C
gene id: 559292:YGR174C
uniprot id: P37267
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBP4 family.
messages: Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.
messages: Mitochondrion inner membrane
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YGR047C
gene id: 559292:YGR047C
uniprot id: P33339
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with TFC1, TFC3, TFC6, TFIIIB subunits BRF1 and BDP1, and with RNA polymerase III subunit RPC10.
messages: Nucleus
messages: Phosphorylated.
messages: Present with 876 molecules/cell in log phase SD medium.
messages: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. TFC4 is the TFIIIB-assembling subunit of TFIIIC and essential for viability.

559292:YOR034C-A
gene id: 559292:YOR034C-A
uniprot id: Q3E735
names: Subcellular Location Annotation
messages: Membrane

559292:YJL158C
gene id: 559292:YJL158C
uniprot id: P47001
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIR protein family.
messages: Component of the outer cell wall layer. Required for stability of the cell wall and for optimal growth. Required for resistance against several antifungal and cell wall-perturbing agents.
messages: Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acid, arising from Gln-74 within the PIR1/2/3 repeat, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
messages: Extensively O-mannosylated. Also N-glycosylated.
messages: Positively regulated by signaling through MPK1 in response to cell wall perturbation.
messages: Present with 12500 molecules/cell in log phase SD medium.
messages: The PIR1/2/3 repeat is required for the covalent linkage to the cell wall.
messages: cell wall

559292:YDL224C
gene id: 559292:YDL224C
uniprot id: Q07655
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Cell cycle-regulated. Expression peaks during S/G2 phase.
messages: Cytoplasm
messages: Has a partially redundant function to WHI3, a dosage-dependent modulator of cell size.
messages: Phosphorylated by PKA in vitro.

559292:YFL054C
gene id: 559292:YFL054C
uniprot id: P43549
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Channel protein that mediates glycerol entry under ethanol stimulation (PubMed:12832087). Does not seem to mediate glycerol uptake under standard conditions (PubMed:12832087).
messages: Decreases the gylcerol uptake in presence of ethanol.

559292:YMR225C
gene id: 559292:YMR225C
uniprot id: P19956
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 1550 molecules/cell in log phase SD medium.

559292:YOL067C
gene id: 559292:YOL067C
uniprot id: P32607
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a heterodimer with RTG3.
messages: Nucleus
messages: Present with 2190 molecules/cell in log phase SD medium.
messages: Required for a novel path of interorganelle communication between mitochondria, peroxisomes and the nucleus, thereby maintaining a functional metabolic interaction between the tricarboxylic acid and glyoxylate cycles. Transcription factor that regulates CIT2 gene expression. Binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (UASR) in the CIT2 promoter. The core binding site is 5'-GGTCAC-3'.

559292:YJR156C
gene id: 559292:YJR156C
uniprot id: P47183
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Present with 752 molecules/cell in log phase SD medium.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

559292:YGL190C
gene id: 559292:YGL190C
uniprot id: Q00362
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa (PR65) (Subunit A) and a 55 kDa (PR55) (Subunit B) regulatory subunit. Interacts with YND1; this interaction mediates adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity and is disrupted by adenovirus E4orf4, which remains associated with both CDC55 and YND1.
messages: Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.
messages: Present with 8600 molecules/cell in log phase SD medium.

559292:YKL045W
gene id: 559292:YKL045W
uniprot id: P20457
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A POL1 and B POL12, and the DNA primase large PRI2 and small PRI1 subunits (PubMed:3061469). Interacts with MCM10 (PubMed:16675460).
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48.
messages: Fluctuates in amount during the cell cycle.

559292:YOL006C
gene id: 559292:YOL006C
uniprot id: P04786
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type IB topoisomerase family.
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: In yeast, topoisomerase I seems to be dispensable. This is thought to be due to the abundant presence of topoisomerase II that can substitute for the relaxing activity of topoisomerase I.
messages: Monomer.
messages: Present with 2970 molecules/cell in log phase SD medium.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
messages: nucleolus
messages: nucleoplasm

559292:YER093C-A
gene id: 559292:YER093C-A
uniprot id: P87275
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM11 family.
messages: Increases frequency of mitochondrial genome loss and leads to synthetic letality with a prohibitin complex subunit PHB1 deletant.
messages: Membrane
messages: Present with 1835 molecules/cell in log phase SD medium.

559292:YER141W
gene id: 559292:YER141W
uniprot id: P40086
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX15/CtaA family.
messages: Forms 200-350 kDa oligomeric complexes independent on heme binding.
messages: Mitochondrion inner membrane
messages: Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin YAH1 and ferredoxin reductase ARH1.

559292:YFL033C
gene id: 559292:YFL033C
uniprot id: P43565
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Phosphorylation by PKA strongly inhibits kinase activity. Phosphorylation by cyclin-CDK PHO80-PHO85 under favorable growth condition causes inactivation of RIM15 by promoting its export to the cytoplasm.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Interacts with the cyclin-dependent kinase (CDK) PHO85 and IGO1.
messages: Kinase activity is inhibited by phosphorylation by cAMP-dependent protein kinase (PKA).
messages: Nucleus
messages: Protein kinase that positively regulates proper entry into stationary phase of cells under nutrient starvation conditions. Involved in glycogen and trehalose accumulation, derepression of stress-induced genes, induction of thermotolerance and starvation resistance, and proper G1 cell cycle arrest. Also involved in the activation of a meiotic genes activation pathway. Phosphorylates IGO1 and IGO2, both involved in the TORC1 control of gene expression and chronological life span.

559292:YBR083W
gene id: 559292:YBR083W
uniprot id: P18412
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEC1 family.
messages: Nucleus
messages: Present with 530 molecules/cell in log phase SD medium.
messages: TEC1 is involved in the activation of TY1 and TY1-mediated gene expression. It is not involved in mating or sporulation processes.

559292:YGL129C
gene id: 559292:YGL129C
uniprot id: Q01163
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS29 binds GTP and is probably an active GTPase. GTP hydrolysis may be linked to subunit association (PubMed:25609543, PubMed:28154081). mS29 also has an extraribosomal function, being required for maintenance of mitochondrial DNA (PubMed:11017876).
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 1300 molecules/cell in log phase SD medium.

559292:YDL114W
gene id: 559292:YDL114W
uniprot id: Q07530
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

559292:YLR393W
gene id: 559292:YLR393W
uniprot id: P18496
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP10 family.
messages: Essential for the assembly of the mitochondrial F1-F0 complex.
messages: Mitochondrion inner membrane
messages: Mutations in ATP10 induce a loss of rutamycin sensitivity of mitochondrial ATPase.
messages: Present with 1890 molecules/cell in log phase SD medium.

559292:YMR191W
gene id: 559292:YMR191W
uniprot id: P42933
names: Function
names: Induction
messages: During stationary phase.
messages: Required for survival at high temperature during stationary phase.

559292:YDR021W
gene id: 559292:YDR021W
uniprot id: Q12099
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
messages: Present with 3090 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YKL091C
gene id: 559292:YKL091C
uniprot id: P33324
names: Miscellaneous
messages: Present with 2870 molecules/cell in log phase SD medium.

559292:YAL044C
gene id: 559292:YAL044C
uniprot id: P39726
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Component of the glycine decarboxylase complex (GDC), which is composed of four proteins: P, T, L and H.
messages: Induced by glycine and repressed by the C1 metabolic end products.
messages: Mitochondrion
messages: Present with 3510 molecules/cell in log phase SD medium.
messages: The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity).

559292:YER110C
gene id: 559292:YER110C
uniprot id: P40069
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Its predominant cargo substrate seems to be ribosomal proteins (PubMed:9321403). Required for import of the ribosomal assembly factor NMD3 (PubMed:12612077). May be involved in nuclear transport of YAP1 (PubMed:11274141). Mediates the nuclear import of histones H3 and H4 (PubMed:11694505). Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015). At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo (PubMed:9321403). The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015).
messages: Interacts with Ran (GSP1); interacts specifically with the GTP-bound form of Ran (GTP-Ran), protecting it from GTP hydrolysis and nucleotide exchange (PubMed:9321403). Interacts with RPL25; this interaction is dissociated by binding to Ran-GTP (PubMed:9321403). Interacts with YAP1 (PubMed:11274141). Interacts with histones H3 and H4; via their NLS (PubMed:11694505).
messages: Nucleus
messages: Present with 38300 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YFL031W
gene id: 559292:YFL031W
uniprot id: P41546
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: By the unfolded protein response pathway. Accumulation of unfolded proteins in the ER leads to activation of IRE1, which initiates splicing of the untranslated HAC1 precursor mRNA to produce the mature form.
messages: Homodimer.
messages: Induced and active isoform.
messages: Not translated. The unspliced HAC1 mRNA is stable, located in the cytoplasm, and is associated with polyribosomes, yet does not produce protein. Translational attenuation is due to basepairing of the intron with the 5'-UTR of the mRNA.
messages: Nucleus
messages: Present with 8970 molecules/cell in log phase SD medium.
messages: Transcriptional activator involved in the unfolded protein response (UPR) pathway. Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes such as KAR2, PDI1, EUG1 and FKB2. Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway.

559292:YGL078C
gene id: 559292:YGL078C
uniprot id: P20447
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Present with 38900 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YPR097W
gene id: 559292:YPR097W
uniprot id: Q06839
names: Domain
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion membrane
messages: Present with 3080 molecules/cell in log phase SD medium.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

559292:YHR168W
gene id: 559292:YHR168W
uniprot id: P38860
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Interacts with the mitochondrial 54S large ribosomal subunit.
messages: Mitochondrion inner membrane
messages: Present with 189 molecules/cell in log phase SD medium.
messages: Required for mitochondrial protein synthesis. May be involved in mitochondrial ribosome biogenesis.

559292:YDL149W
gene id: 559292:YDL149W
uniprot id: Q12142
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG9 family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer (By similarity). Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes (By similarity).
messages: Golgi apparatus membrane
messages: Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets (PubMed:33106658). Interacts with ATG23 and ATG27 to form a cycling complex for trafficking to the PAS (PubMed:14504273, PubMed:17178909, PubMed:27050455). Interacts (via N-terminus) with ATG11, required for recruitment of ATG9 to the PAS for the Cvt pathway during nutrient-rich conditions (PubMed:17178909, PubMed:17192412, PubMed:19371383, PubMed:31356628). Interacts (via N-terminus) with ATG17; required for recruitment to the PAS during autophagy and starved conditions (PubMed:19371383). Interacts with ATG2 and ATG18; required for the retrieval of ATG9 from the PAS to the cytoplasmic pool (PubMed:11382760, PubMed:14723849, PubMed:24905091, PubMed:24440502). Interacts with ATG41 (PubMed:26565778). Interacts with the conserved oligomeric Golgi (COG) complex subunits COG3 and COG4 (PubMed:20065092). Interacts with TRS85 (PubMed:23129774).
messages: Mitochondrion membrane
messages: Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation (PubMed:7593182, PubMed:8224160, PubMed:8663607, PubMed:10735854, PubMed:14504273, PubMed:24440502, PubMed:27050455, PubMed:33106658, PubMed:33439214). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:10662773, PubMed:11689437, PubMed:17329962, PubMed:17426440, PubMed:18829864, PubMed:22826123, PubMed:24905091, PubMed:33439214). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106658, PubMed:32883836, PubMed:33439214). Required for mitophagy (PubMed:18818209). Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (PubMed:17132049). Recruits vesicle-tethering proteins TRS85 and YPT1 to the autophagosome formation site (PubMed:23129774). Recruits also ATG23 and ATG8 to the PAS (PubMed:14504273).
messages: Phosphorylated by ATG1; phosphorylation is required for autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation (PubMed:24440502). Phosphorylation by ATG1 regulates ATG18 interaction and preautophagosome elongation (PubMed:24905091). Phosphorylation at Ser-122 is required for selective autophagy by regulating anterograde trafficking and interaction with ATG23 and ATG27 (PubMed:27050455, PubMed:33443148). Phosphorylation at Ser-122 prevents ubiquitination by the SCF(MET30) complex (PubMed:33443148).
messages: Preautophagosomal structure membrane
messages: Ubiquitinated by the SCF(MET30) complex in normal conditions, leading to its degradation by the proteasome, thereby preventing inappropriate induction of autophagy (PubMed:33443148). Ubiquitination by the SCF(MET30) complex is prevented by phosphorylation at Ser-122 (PubMed:33443148).

559292:YDL214C
gene id: 559292:YDL214C
uniprot id: Q12310
names: Function
names: Induction
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: By the macrolide rapamycin in a TOR-dependent manner.
messages: Protein kinase that functions as regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3. Diminishes transcriptional induction of genes in response to pheromone signaling.

559292:YKL053C-A
gene id: 559292:YKL053C-A
uniprot id: O60200
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIAP1/MDM35 family.
messages: Cytoplasm
messages: Interacts with UPS1, UPS2 and UPS3.
messages: Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071602, PubMed:26071601, PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602).
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Present with 3870 molecules/cell in log phase SD medium.

559292:YOR108W
gene id: 559292:YOR108W
uniprot id: Q12166
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Redundant to LEU4, responsible of about 20% of alpha-IPMS activity. Involved in leucine synthesis.
messages: Mitochondrion
messages: Present with 28800 molecules/cell in log phase SD medium.

559292:YHR163W
gene id: 559292:YHR163W
uniprot id: P38858
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Cytoplasm
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
messages: Nucleus
messages: Present with 3420 molecules/cell in log phase SD medium.

559292:YER054C
gene id: 559292:YER054C
uniprot id: P40036
names: Miscellaneous
names: Subunit
messages: Interacts with phosphatase 1 (GLC7).
messages: Present with 125 molecules/cell in log phase SD medium.

559292:YOR249C
gene id: 559292:YOR249C
uniprot id: Q08683
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1. APC5 directly interacts with MND2 and SWM1.

559292:YOL038W
gene id: 559292:YOL038W
uniprot id: P40303
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 16800 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with CIC1.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

559292:YDL138W
gene id: 559292:YDL138W
uniprot id: Q12300
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Interacts with YCK1 (PubMed:14755054). Interacts with MTH1 and STD1 (PubMed:27630263).
messages: Low-affinity high glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell (PubMed:9564039, PubMed:14755054, PubMed:27630263). The transporter-like sensor generates an intracellular signal in the presence of high levels of glucose to promote high glucose-induced expression of HXT1 (PubMed:9564039). Binding of glucose to the RGT2 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (PubMed:8901598, PubMed:27630263). Even though RGT2 is similar to glucose transporters, it appears to be unable to transport glucose (PubMed:9564039).
messages: Phosphorylated in the C-terminal tail on Yck consensus sites in a yeast casein kinases YCK1 and YCK2 (Yck)-dependent manner. This phosphorylation is required for interaction with HXT corepressors MTH1 and STD1 and ultimately HXT expression.

559292:YMR275C
gene id: 559292:YMR275C
uniprot id: P48524
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUL1 family.
messages: Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1. The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2.
messages: Component of the RSP5-BUL1/2 ubiquitin ligase complex composed of at least RSP5 and BUL1 or BUL2.
messages: Cytoplasm
messages: Present with 486 molecules/cell in log phase SD medium.
messages: The PY-motif is required for the interaction with RSP5 ubiquitin-ligase and the HSE-mediated gene expression.

559292:YDR067C
gene id: 559292:YDR067C
uniprot id: Q12454
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cytoplasm
messages: Required for replication of Brome mosaic virus (BMV).

559292:YDR300C
gene id: 559292:YDR300C
uniprot id: P32264
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline.
messages: Cytoplasm
messages: Present with 10400 molecules/cell in log phase SD medium.

559292:YHL024W
gene id: 559292:YHL024W
uniprot id: P38741
names: Function
names: Induction
names: PTM
messages: Expressed at elevated levels early in meiosis. Expression depends on IME1.
messages: Polyubiquitinated by RSP5.
messages: Positive regulator of sporulation-specific genes and of sporulation. Required for premeiotic DNA synthesis and meiotic chromosomal segregation. May act in a nutritional signaling pathway.

559292:YEL077C
gene id: 559292:YEL077C
uniprot id: Q3E7X8
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YGL075C
gene id: 559292:YGL075C
uniprot id: P53159
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MPS2 family.
messages: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.
messages: Interacts with BBP1, MPS3, and SPC24.
messages: Nucleus membrane
messages: spindle pole body

559292:YER009W
gene id: 559292:YER009W
uniprot id: P33331
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. In vitro, the NTF2-Ran-GDP association, in the presence of GTP, triggers dissociation of the karyopherin alpha-beta complex, allowing nuclear translocation of karyopherin alpha and the NLS substrate.

559292:YPL075W
gene id: 559292:YPL075W
uniprot id: P07261
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer via the leucine-zipper domain. Forms a complex with a GCR2 homodimer. Interacts with RAP1.
messages: Nucleus
messages: Phosphorylated in a GCR2-dependent manner.
messages: Present with 259 molecules/cell in log phase SD medium.
messages: Transcriptional activator required for the expression of glycolytic and ribosomal genes. Forms a transcriptional activation complex with RAP1, RAP1 providing the specific DNA-binding function and GCR1 providing the activation function. Can also bind itself to DNA to a core 5'-CTTCC-3' sequence (CT box). CT box-binding is not essential, but enhances the activation function of the RAP1-GCR1 complex in promoters that contain both DNA signals (only glycolytic genes). CT box-dependent transcriptional activation requires GCR2.

559292:YDR160W
gene id: 559292:YDR160W
uniprot id: Q03770
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Amino acid sensor component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Amino-acid permease homolog that seems to interact directly with the extracellular signaling molecules, but has no amino acid transporter activity. May recruit casein kinases YCK1 and YCK2 to hyperphosphorylate and activate downstream component PTR3 in response to amino acid stimulus.
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Cell membrane
messages: Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex. Interacts directly with PTR3 and SSY5. Interacts with YCK1.

559292:YNL108C
gene id: 559292:YNL108C
uniprot id: P53929
names: Miscellaneous
names: Similarity
messages: Present with 1950 molecules/cell in log phase SD medium.
messages: To yeast YOR110w.

559292:YLR256W
gene id: 559292:YLR256W
uniprot id: P0CE41
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a homodimer. Interacts with SRO9 and YDJ1. In the absence of heme, binds to at least four cellular proteins, including YDJ1 and SRO9, forming a high-molecular-weight complex (HMC) which results in repression of its activity and dictates its DNA-binding specificity (By similarity).
messages: Heme is an effector molecule for CYP1/HAP1. The HRM repeat region mediates heme induction by masking the DNA-binding domain in the absence of inducer (By similarity).
messages: Nucleus
messages: Regulation of oxygen dependent gene expression. It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c. In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes. Binds to the sequence 5'-CGGNNNTNNCGG-3' (By similarity). Is non-functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives.
messages: The sequence for strain S288c and its derivatives differs from other strain backgrounds due to the insertion of a defective Ty1 element in the C-terminus. This acts as a null allele in terms of iso-1 cytochrome c expression and beta-galactosidase activity. Also, the expression levels of ergosterol-related genes and ergosterol content are decreased in laboratory strain X2180 caused by the defective Ty1 insertion. The sequence of a wild-type allele can be found in other strain backgrounds (AC P0CS82).

559292:YOL017W
gene id: 559292:YOL017W
uniprot id: Q08119
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with GAL11 and SIR2.
messages: Involved in HMR and telomere silencing via the recruitment or stabilizing of the SIR (silent information regulators) complex.
messages: Nucleus
messages: Present with 432 molecules/cell in log phase SD medium.

559292:YGL105W
gene id: 559292:YGL105W
uniprot id: P46672
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tRNA-aminoacylation cofactor ARC1 family.
messages: Binds to tRNA and functions as a cofactor for the methionyl-tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRS). Forms a complex with MetRS and GluRS and increases their affinity for cognate tRNAs due to the presence of a tRNA binding domain in its middle and C-terminal part. Binds specifically G4 quadruplex nucleic acid structures (these are four-stranded right-handed helices, stabilized by guanine base quartets). Also required for cytoplasmic confinement of the synthetases and tRNA.
messages: Component of a yeast aminoacyl-tRNA synthase (aaRS) complex formed by methionyl-tRNA synthase MES1, glutamyl-tRNA synthase GUS1 and the tRNA aminoacylation cofactor ARC1 in a stoichiometric complex. Interacts (via N-ter) with MES1 (via N-ter) and GUS1 (via N-ter). Can also form a stable binary complex with either MES1 or GUS1 that is functional in terms of aminoacylation.
messages: Cytoplasm
messages: Present with 57700 molecules/cell in log phase SD medium.

559292:YNL151C
gene id: 559292:YNL151C
uniprot id: P17890
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. C31 is involved in the formation of the initiation complex.
messages: Nucleus
messages: The acidic domain is essential for its function.

559292:YGL071W
gene id: 559292:YGL071W
uniprot id: P22149
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 2730 molecules/cell in log phase SD medium.
messages: Probable transcription factor that activates the genes for FRE1, FRE2 and FET3 in response to iron deprivation (PubMed:7720713, PubMed:9200812). Also required for the expression of LSO1 (PubMed:26450372). Iron could interact directly with AFT1 and inhibits its activity (PubMed:7720713).
messages: Two-fold reduction in expression of LSO1.

559292:YBL038W
gene id: 559292:YBL038W
uniprot id: P38064
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 2900 molecules/cell in log phase SD medium.

559292:YGL038C
gene id: 559292:YGL038C
uniprot id: P31755
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Endoplasmic reticulum membrane
messages: Expression is regulated by SKN7, SLN1, and CDC4.
messages: Glycosylated.
messages: Golgi apparatus membrane
messages: Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. Has also the potential to transfer a second alpha-1,6-mannose to the Man(8)GlcNAc(2) core oligosaccharide.
messages: Present with 9490 molecules/cell in log phase SD medium.
messages: Stops growing at the early stage of bud formation and rapidly loses viability at the non-permissive temperature. Exhibits a defect in the initiation of the mannose outer chain. Leads to accumulation of free forms of oligosaccharides (fOSs).
messages: The conserved DXD motif is involved in enzyme activity.

559292:YGR273C
gene id: 559292:YGR273C
uniprot id: P53329
names: Similarity
messages: To yeast YMR295c.

559292:YJL099W
gene id: 559292:YJL099W
uniprot id: P40955
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes CHS3 localization to the bud neck and plasma membrane, with increased protein localization to the trans-Golgi cisternae.
messages: Belongs to the CHAPS family.
messages: Component of the CHS5/6 complex composed of the 4 CHAPS proteins BCH1, BCH2, BUD7, and CHS6 as well as at least CHS5 and GTP-bound ARF1. The complex interacts with the cargo protein CHS3.
messages: Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.
messages: Present with 1180 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YGR084C
gene id: 559292:YGR084C
uniprot id: P12686
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS44 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 16000 molecules/cell in log phase SD medium.

559292:YJR060W
gene id: 559292:YJR060W
uniprot id: P17106
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a dimer. Associates with MET4 to form a heteromeric complex which also includes MET28.
messages: Mitochondrion
messages: Nucleus
messages: Present with 6890 molecules/cell in log phase SD medium.
messages: Required for chromosome stability and methionine prototrophy. It is involved in chromosomal segregation. Binds to a highly conserved DNA sequence (5'-RTCACRTG-3'), called CDEI, found in centromeres and in several promoters. DNA-binding activity is enhanced by MET28. Required as an auxiliary factor for transcriptional activation of sulfur metabolism together with MET4 and MET28.
messages: centromere

559292:YKL117W
gene id: 559292:YKL117W
uniprot id: P28707
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as a co-chaperone.
messages: Belongs to the p23/wos2 family.
messages: Interacts with HSP82.
messages: Present with 33700 molecules/cell in log phase SD medium.

559292:YPL254W
gene id: 559292:YPL254W
uniprot id: Q12060
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 1.8 MDa SAGA complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9. Component of the ADA/GCN5 complex, that consists of HFI1/ADA1, ADA2, ADA3, SPT20/ADA5 and GCN5 and is probably a subcomplex of SAGA.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. HFI1/ADA1 and SPT20/ADA5 may recruit TATA binding protein (TBP) and possibly other basal factors to bind to the TATA box.
messages: Nucleus
messages: Present with 7950 molecules/cell in log phase SD medium.

559292:YGR188C
gene id: 559292:YGR188C
uniprot id: P41695
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
messages: Involved in cell cycle checkpoint enforcement. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism. Catalyzes the phosphorylation of BUB3 and its autophosphorylation. Associates with centromere (CEN) DNA via interaction with SKP1. The association with SKP1 is required for the mitotic delay induced by kinetochore tension defects, but not for the arrest induced by spindle depolymerization or kinetochore assembly defects.
messages: Nucleus
messages: Part of complex consisting of MAD1, BUB1 and BUB3 after activation of spindle checkpoint.
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YMR189W
gene id: 559292:YMR189W
uniprot id: P49095
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: By glycine.
messages: Component of the glycine decarboxylase complex (GDC), which is composed of four proteins: P, T, L and H.
messages: Mitochondrion
messages: Present with 12000 molecules/cell in log phase SD medium.
messages: The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

559292:YPL242C
gene id: 559292:YPL242C
uniprot id: Q12280
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Interacts with AFR1, AKR1, activated CDC42, calmodulin (CMD1), myosin MYO1 and its light chain MLC1, BUD4, INN1, SEC3 and TEM1.
messages: Present with 279 molecules/cell in log phase SD medium.
messages: Required for the assembly and the contraction of the actomyosin ring at the bud neck during cytokinesis. Seems to be involved in additional tasks during cell division like axial bud-site selection and targeted secretion by recruiting the spatial landmark BUD4, the septin CDC12 and the secretion landmark SEC3 to the bud neck. May be regulated by calcium ions.
messages: The IQ domains provide the interaction surface for the myosin light chain MLC1.
messages: The Ras-GAP domain is required for contraction of the actomyosin ring and is needed for the interaction with TEM1. It probably does not stimulate GTPase activity.
messages: The calponin homology (CH) domain binds to actin filaments and is required for their recruitment to the bud neck.

559292:YHR204W
gene id: 559292:YHR204W
uniprot id: P38888
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha-1,2-specific exomannosidase involved in endoplasmic reticulum-associated degradation (ERAD). Delivers misfolded glycoproteins to proteasomes. Forms a complex with PDI1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response.
messages: Belongs to the glycosyl hydrolase 47 family.
messages: Endoplasmic reticulum lumen
messages: Interacts with PDI1.
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YLR168C
gene id: 559292:YLR168C
uniprot id: P35200
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the slowmo family.
messages: Defects in mitochondrial morphology.
messages: Interacts with MDM35.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Present with 2910 molecules/cell in log phase SD medium.
messages: Required for mitochondrial cristae morphogenesis and MGM1-processing. Controls the stability of mitochondrial phosphatidylethanolamine (PE). With UPS1, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.

559292:YKL085W
gene id: 559292:YKL085W
uniprot id: P17505
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.
messages: Mitochondrion matrix
messages: Present with 28100 molecules/cell in log phase SD medium.
messages: Yeast contains at least 3 malate dehydrogenase isoenzymes: a mitochondrial (MDH1), a cytoplasmic (MDH2) and a peroxisomal (MDH3).

559292:YDL168W
gene id: 559292:YDL168W
uniprot id: P32771
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: By formaldehyde, ethanol and methyl methanesulphonate.
messages: Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde (PubMed:8483449). Is responsible for yeast resistance to formaldehyde (PubMed:8483449).
messages: Present with 8370 molecules/cell in log phase SD medium.
messages: Requires GSH for oxidation of formaldehyde or of methylglyoxal, while oxidation of long-chain alcohols is independent of GSH and enzyme activity improves with chain length.

559292:YDR533C
gene id: 559292:YDR533C
uniprot id: Q04432
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C56 family. HSP31-like subfamily.
messages: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals (PubMed:24302734). Involved in protection against reactive oxygen species (ROS) (PubMed:17395014). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893).
messages: Cys-138 is easily oxidized to sulfinic acid.
messages: Homodimer.
messages: No protease activity could be detected.
messages: P-body
messages: Present with 358 molecules/cell in log phase SD medium.
messages: Results in higher sensitivity to oxidative stress, reduced thermotolerance, accumulation of higher levels of reactive oxygen species, and reduced chronological life span.
messages: Up-regulated 10- to 30-fold during entry into stationary phase, by hydrogen peroxide or diamide stress, by heat stress, and by growth in the presence of the proline analog azetidine-2-carboxylic acid.

559292:YDR322W
gene id: 559292:YDR322W
uniprot id: Q06678
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 7700 molecules/cell in log phase SD medium.

559292:YOR068C
gene id: 559292:YOR068C
uniprot id: Q08474
names: Function
names: Subcellular Location Annotation
messages: Required for vacuolar fusion. Involved in the early steps of the fusion pathway.
messages: Vacuole membrane

559292:YHR176W
gene id: 559292:YHR176W
uniprot id: P38866
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FMO family.
messages: Flavin-dependent oxidation of thiol-containing compounds. Probably required for the correct folding of disulfide-bonded proteins.
messages: Monomer.

559292:YPL196W
gene id: 559292:YPL196W
uniprot id: Q08952
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXR1 family.
messages: Involved in protection from oxidative damage.
messages: Mitochondrion
messages: Present with 1560 molecules/cell in log phase SD medium.
messages: Up-regulated by heat and oxidative stress.

559292:YBR246W
gene id: 559292:YBR246W
uniprot id: P38332
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulates diphthine, the last intermediate in the diphthamide biosynthesis pathway. Increases the interaction of DPH5 with elongation factor 2.
messages: Belongs to the DPH7 family.
messages: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate in diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EFT1 and EFT2). Also plays a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Identified in a screen for mutants with decreased levels of rDNA transcription.
messages: Cytoplasm
messages: Endosome
messages: Interacts with CAN1 and RTT10.
messages: Present with 2640 molecules/cell in log phase SD medium.
messages: Was originally (PubMed:19965467) thought to be required for the first step of diphthamide biosynthesis but further studies (PubMed:22188241, PubMed:23468660) clearly suggest that it is involved in the third step of diphthamide biosynthesis.

559292:YMR074C
gene id: 559292:YMR074C
uniprot id: Q04773
names: Miscellaneous
names: Similarity
messages: Belongs to the PDCD5 family.
messages: Present with 2550 molecules/cell in log phase SD medium.

559292:YDR463W
gene id: 559292:YDR463W
uniprot id: Q00947
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the amino acid-induced proteolytic removal of an N-terminal inhibitory domain by serine protease SSY5, an intrinsic component of the SPS-sensor. Processing requires at least 2 components of the SCF(GRR1) ubiquitin ligase complex, namely the F-box protein GRR1 and the E2 enzyme CDC34, but does not depend on the proteasome. Processing is negatively regulated by the protein phosphatase 2A regulatory subunit RTS1.
messages: Cell membrane
messages: Interacts (via Region II) with SSY5; protease component of the SPS-sensor.
messages: Nucleus
messages: Phosphorylated by casein kinase I. Phosphorylation is not dependent on the extracellular amino acid levels, but is a prerequisite for proteolytic processing.
messages: Present with 1310 molecules/cell in log phase SD medium.
messages: The N-terminal inhibitory domain contains conserved sequence elements important for cytoplasmic retention (Region I) and proteolytic processing (Region II) of the protein. Region I is also required for ASI1/2/3-mediated negative regulation of transcription.
messages: Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases AGP1, BAP2, BAP3 and GNP1. Binding to promoters is facilitated by DAL81. Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes. May be involved in pre-tRNA splicing.
messages: Was originally thought to be an amino-acid permease.

559292:YJL102W
gene id: 559292:YJL102W
uniprot id: P39677
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation (By similarity). Required for respiratory growth and essential for mitochondrial genome maintenance.
messages: Mitochondrion
messages: Present with 1733 molecules/cell in log phase SD medium.
messages: Results in loss of mitochondrial DNA. Causes a significant slow growth phenotype under normal growth conditions (glucose) and a reduced chronological life-span (CLS). Growth on a non-fermentable carbon source (gylcerol) is absent.

559292:YPL274W
gene id: 559292:YPL274W
uniprot id: Q08986
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Endoplasmic reticulum
messages: High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source.
messages: Membrane
messages: Present with 1300 molecules/cell in log phase SD medium.

559292:YLL064C
gene id: 559292:YLL064C
uniprot id: P0CE90
uniprot id: P0CE91
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YNL083W
gene id: 559292:YNL083W
uniprot id: D6W196
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Calcium-dependent mitochondrial solute carrier.
messages: Mitochondrion inner membrane
messages: Present with 1170 molecules/cell in log phase SD medium.
messages: Strain S288c has a frameshift in position 403, which disrupts the gene coding for this protein and produces the non-functional allele sal1-1. A full-length functional allele can be found in strain CG379 (AC P0CI40).

559292:YLR058C
gene id: 559292:YLR058C
uniprot id: P37291
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Cytoplasm
messages: Homotetramer.
messages: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
messages: Interconversion of serine and glycine.
messages: Present with 67600 molecules/cell in log phase SD medium.

559292:YGR043C
gene id: 559292:YGR043C
uniprot id: P53228
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Homodimer.
messages: Present with 1920 molecules/cell in log phase SD medium.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

559292:YBL066C
gene id: 559292:YBL066C
uniprot id: P34228
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Nucleus
messages: Putative transcription factor that seems to be involved in the sporulation process. Suppresses the lethal phenotype of RPM2 deletion.
messages: Sequencing errors.

559292:YKR097W
gene id: 559292:YKR097W
uniprot id: P10963
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Homotetramer.

559292:YML104C
gene id: 559292:YML104C
uniprot id: Q01846
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Essential for mitotic growth. Mediates organelle inheritance.
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YLR439W
gene id: 559292:YLR439W
uniprot id: P36517
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 7700 molecules/cell in log phase SD medium.

559292:YGR169C
gene id: 559292:YGR169C
uniprot id: P53294
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase RluA family.
messages: Catalyzes the formation of pseudouridine at position 31 in the psi GC loop of tRNAS.
messages: Cytoplasm
messages: Mitochondrion
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YPR007C
gene id: 559292:YPR007C
uniprot id: Q12188
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Chromosome
messages: During meiosis.
messages: Nucleus
messages: Phosphorylated by CDC5. CDC5 phosphorylation is necessary for cleavage by ESP1 and subsequent removal from chromosome arms.
messages: Proteolytically cleaved by ESP1.
messages: Replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis (PubMed:10412984, PubMed:10691741, PubMed:11081626, PubMed:11163190, PubMed:12101124, PubMed:12663816, PubMed:12665553, PubMed:12717442, PubMed:15062096, PubMed:15120066, PubMed:15819623, PubMed:16027219, PubMed:9784122). Is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate (PubMed:11081626). Is protected from cleavage by SPO13 (PubMed:15620644). Promotes localization of the LINC complex subunit MPS3 on nuclear envelope in mitotic cells (PubMed:30417519).
messages: centromere

559292:YGL003C
gene id: 559292:YGL003C
uniprot id: P53197
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.
messages: Associates with the APC/C complex. Interacts with CLB2, CLB3, CDC5, HSL1, MSN5 and PSE1.
messages: Belongs to the WD repeat CDC20/Fizzy family.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated at multiple sites by CDC28, probably in its CLB5 bound form, in S, G2 and M phase of the cell cycle, thereby blocking the association of CDH1 to the APC/C and promoting nuclear export of CDH1 by MSN5. Dephosphorylated and activated by CDC14 in late anaphase, which may be necessary for PSE1-dependent nuclear localization.
messages: The C-box is required for the association with the APC/C complex.

559292:YJL147C
gene id: 559292:YJL147C
uniprot id: P47007
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion
messages: Present with 981 molecules/cell in log phase SD medium.

559292:YPL241C
gene id: 559292:YPL241C
uniprot id: P46670
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Present with 1630 molecules/cell.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

559292:YOR002W
gene id: 559292:YOR002W
uniprot id: Q12001
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

559292:YPR121W
gene id: 559292:YPR121W
uniprot id: Q06490
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Although highly homologous to the 2 other thiaminase-2 family members THI20 and THI21 in yeast, no hydroxymethylpyrimidine phosphate kinase activity could be demonstrated for this protein.
messages: Belongs to the thiaminase-2 family.
messages: By absence of thiamine.
messages: Is not required for thiamine biosynthesis.
messages: Secreted

559292:YLR042C
gene id: 559292:YLR042C
uniprot id: Q07990
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Induced in response to cell wall damage.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

559292:YLR437C
gene id: 559292:YLR437C
uniprot id: O13577
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DIF1/spd1 family.
messages: Cytoplasm
messages: During S phase of cell cycle.
messages: Interacts with RNR2 and RNR4.
messages: Mediates the nuclear localization of RNR2 and RNR4, 2 subunits of the ribonucleotide reductase.
messages: Nucleus
messages: Phosphorylated by DUN1 in response to DNA damage which leads to its degradation.

559292:YPL179W
gene id: 559292:YPL179W
uniprot id: P32945
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Phosphatase involved in the regulation of protein synthesis. Affects translational accuracy.
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YPL215W
gene id: 559292:YPL215W
uniprot id: P21560
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBP3 family.
messages: Chaperone required for the assembly of ubiquinol-cytochrome c reductase of the mitochondrial respiratory chain.
messages: Mitochondrion membrane
messages: Present with 14200 molecules/cell in log phase SD medium.

559292:YAL040C
gene id: 559292:YAL040C
uniprot id: P13365
names: Function
names: Induction
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.
messages: Not significantly cell cycle regulated.

559292:YNL066W
gene id: 559292:YNL066W
uniprot id: P53616
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUN family.
messages: Expression is decreased during transition to slow growing or stationary phases.
messages: Glycosylated.
messages: Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation.
messages: Leads to increased resistance to zymolyase treatment.
messages: Present with 24700 molecules/cell in log phase SD medium.
messages: cell wall

559292:YKR080W
gene id: 559292:YKR080W
uniprot id: Q02046
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 16200 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YMR220W
gene id: 559292:YMR220W
uniprot id: P24521
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Cytoplasm
messages: Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:1846667). ERG8 converts 5-phosphomevalonate to 5-diphosphomevalonate (PubMed:1846667). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672).
messages: Present with 79 molecules/cell in log phase SD medium.

559292:YOR254C
gene id: 559292:YOR254C
uniprot id: P14906
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC63 may affect SEC1-polypeptide interactions by increasing the affinity of targeting pathways for SEC61 and/or by modifying SEC61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation. Is essential for cell growth and for germination.
messages: Component of the heterotetrameric Sec62/63complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. SEC63 interacts in its phosphorylated form with SEC62. May physically associate with KAR2 in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis. Part of a complex consisting of KAR2, SEC63, SEC66 and SEC72.
messages: Endoplasmic reticulum membrane
messages: Nucleus inner membrane
messages: Nucleus membrane
messages: Phosphotylated by casein kinase II.
messages: Present with 17700 molecules/cell in log phase SD medium.

559292:YGL085W
gene id: 559292:YGL085W
uniprot id: P53153
names: Disruption Phenotype
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LCL3 family.
messages: By DNA-damaging agent methyl methanesulphonate (MMS) (at protein level).
messages: Leads to long chronological lifespan.
messages: Membrane
messages: Mitochondrion
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YPR159W
gene id: 559292:YPR159W
uniprot id: P32486
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKN1/KRE6 family.
messages: Golgi apparatus membrane
messages: Involved in the synthesis of (1->6)- and (1->3)-beta-D-glucan polymers of the yeast cell wall in vivo. It is required for full activity of beta-glucan synthase in vitro. May be involved in the maturation and transport of cell wall proteins (CWP) to the cell wall. May act as a transglucosidase and contribute to the construction of a protein-bound glucan-structure that acts as an acceptor site for the addition of (1->6)-beta-D-glucan at the cell surface.
messages: Present with 4760 molecules/cell in log phase SD medium.
messages: The cytoplasmic domain interacts with the actin patch assembly proteins LAS17 and SLA1. Interacts with KEG1.

559292:YGR170W
gene id: 559292:YGR170W
uniprot id: P53037
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (PubMed:7890740, PubMed:7890739, PubMed:24366873). Phosphatidylethanolamine produced by PSD2 is insufficient to completely provide the PtdEtn pool required by mitochondria under respiratory conditions (PubMed:11294902). PSD2 is also involved in the PtdSer transport step to the site of PtdEtn synthesis on the Golgi/endosome membranes (PubMed:24366873). Required for normal heavy metal resistance (PubMed:20016005).
messages: Decreases induction of mitophagy in stationary phase following growth on a respiratory carbon source.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit (By similarity). Interacts with pstB2/PDR17 (PubMed:20016005, PubMed:24366873). This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2/PDR17 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis (PubMed:24366873).
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: The C2 domains have an essential, but non-catalytic function (Probable) (PubMed:24366873). Both C2-1 and C2-2 facilitate interaction with PstB2/PDR17 and are required for lipid transport function (PubMed:24366873).

559292:YKL215C
gene id: 559292:YKL215C
uniprot id: P28273
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the oxoprolinase family.
messages: Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Cytoplasm
messages: Homodimer.
messages: Present with 3180 molecules/cell in log phase SD medium.

559292:YNR058W
gene id: 559292:YNR058W
uniprot id: P50277
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA) (PubMed:10333520). It is the only aminotransferase known to utilize SAM as an amino donor (PubMed:10333520).

559292:YML019W
gene id: 559292:YML019W
uniprot id: Q03723
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST3/OST6 family.
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:10358084, PubMed:16297388, PubMed:16096345, PubMed:15886282). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Present with 1080 molecules/cell in log phase SD medium.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:11580295). Can participate in redox reactions and is able to catalyze dithiol-disulfide exchange reactions with other proteins, albeit with relatively low efficiency. May form transient disulfide bonds with nascent polypeptides in the endoplasmic reticulum and thereby promote efficient glycosylation (PubMed:19549845).

559292:YOL053W
gene id: 559292:YOL053W
uniprot id: Q08223
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM39 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion membrane

559292:YGR166W
gene id: 559292:YGR166W
uniprot id: P32893
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS120 and TRS130. Interacts directly with TRS120 and TRS130.
messages: Present with 1660 molecules/cell in log phase SD medium.
messages: Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchanger (GEF) for the Golgi YPT1 GTPase. TRS65 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS120 and TRS130. Involved in cell wall (1-->6)-beta-glucan synthesis.
messages: cis-Golgi network

559292:Q0160
gene id: 559292:Q0160
uniprot id: P03882
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAGLIDADG endonuclease family.
messages: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the 21S rRNA gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Specifically recognizes and cleaves the sequence 5'-TAGGGATAACAGGGTAAT-3'.
messages: Mitochondrion
messages: Monomer.

559292:YGR058W
gene id: 559292:YGR058W
uniprot id: P53238
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds calcium via its EF-hands.
messages: Bud neck
messages: Bud tip
messages: Calcium-binding protein that is required for polar bud growth and cell wall abscission. Can also bind zinc ions.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YBR126C
gene id: 559292:YBR126C
uniprot id: Q00764
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by fructose 6-phosphate. Inorganic phosphate inhibits the synthase activity in the complex, but activates the synthase activity in the free monomeric form.
messages: Belongs to the glycosyltransferase 20 family.
messages: Cytoplasm
messages: Either partial repression by glucose or induction by galactose. Induced by heat shock.
messages: Present with 10900 molecules/cell in log phase SD medium.
messages: Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process. Can function independently of the complex.
messages: The trehalose synthase complex is composed of the two catalytic subunits TPS1 and TPS2 and at least one of the two regulatory subunits TPS3 or TSL1.

559292:YDR454C
gene id: 559292:YDR454C
uniprot id: P15454
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the guanylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphoryl group of ATP to the acceptor molecule GMP. Essential for recycling GMP and indirectly, cGMP.
messages: Monomer.
messages: Present with 20500 molecules/cell in log phase SD medium.

559292:YGR029W
gene id: 559292:YGR029W
uniprot id: P27882
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins.
messages: Homodimer. Interacts with MIA40, forming transient intermolecular disulfide bridges.
messages: Mitochondrion intermembrane space

559292:YNR028W
gene id: 559292:YNR028W
uniprot id: P53728
names: Function
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

559292:YLR104W
gene id: 559292:YLR104W
uniprot id: Q08045
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the LCL2 family.
messages: Leads to long chronological lifespan.
messages: Present with 1990 molecules/cell in log phase SD medium.
messages: Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway that acts upstream of HRD3 and USA1.

559292:YNL255C
gene id: 559292:YNL255C
uniprot id: P53849
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May act in the sexual differentiation pathway.
messages: Present with 96655 molecules/cell in log phase SD medium.

559292:YIL007C
gene id: 559292:YIL007C
uniprot id: P40555
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC). During the base subcomplex assembly is part of a NAS2:RPT4:RPT5 module; NAS2 is released during the further base assembly process.
messages: Belongs to the proteasome subunit p27 family.
messages: Part of a transient complex containing NAS2, RPT4 and RPT5 formed during the assembly of the 26S proteasome.
messages: Present with 846 molecules/cell in log phase SD medium.

559292:YLR060W
gene id: 559292:YLR060W
uniprot id: P15624
names: Caution
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Present with 5440 molecules/cell in log phase SD medium.
messages: Tetramer of two alpha and two beta subunits.
messages: Was originally erroneously assigned as an alpha subunit.

559292:YJL048C
gene id: 559292:YJL048C
uniprot id: P47049
names: Function
names: Miscellaneous
messages: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
messages: Present with 1340 molecules/cell in log phase SD medium.

559292:YGR007W
gene id: 559292:YGR007W
uniprot id: P33412
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylyltransferase family.
messages: By isooctane.
messages: Cytoplasm
messages: Ethanolamine-phosphate cytidylyltransferase which catalyzes the second step of phosphatidylethanolamine biosynthesis. Involved in the maintenance of plasma membrane and required for proper sporulation.
messages: Nucleus
messages: Present with 4700 molecules/cell in log phase SD medium.

559292:YJL213W
gene id: 559292:YJL213W
uniprot id: P40896
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

559292:YHR077C
gene id: 559292:YHR077C
uniprot id: P38798
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in nonsense-mediated decay of mRNAs containing premature stop codons. It interacts, via its C-terminus, with NAM7/UPF1. Could be involved in determining the efficiency of translational termination or reinitiation or factors involved in the initial assembly of an initiation- and termination-competent mRNP.
messages: Present with 1280 molecules/cell in log phase SD medium.

559292:YNR046W
gene id: 559292:YNR046W
uniprot id: P53738
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase MTQ2, required for the methylation of eRF1 on 'Gln-182'. Together with methyltransferase TRM11, required for the formation of 2-methylguanosine at position 10 (m2G10) in tRNA. Together with methyltransferase BUD23, required for the formation of 7-methylguanine at position 1575 (m7G1575) in 18S rRNA. Involved in biogenesis of both 40S and 60S ribosomal subunits.
messages: Belongs to the TRM112 family.
messages: Cytoplasm
messages: Heterodimer of MTQ2-TRM112, forming the eRF1 methyltransferase. TRM112 is necessary for the solubility and activity of the catalytic subunit MTQ2. Interacts with TRM11; required for full tRNA methyltransferase activity. Interacts with BUD23; required for full rRNA methyltransferase activity. Interacts with RCM1, NOP2, TRM9 and LYS9.
messages: Nucleus
messages: Present with 4800 molecules/cell in log phase SD medium.

559292:YHR165C
gene id: 559292:YHR165C
uniprot id: P33334
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with PRP40 and SNP1. Interacts (via SCwid domain) with CWC21. Interacts (via SCwid domain) with SNU114 (via N-terminus). Interacts (via RNase H homology domain and MPN domain) with BRR2; this modulates BRR2 ATPase and helicase activity. Interacts (via RNase H homology domain) with AAR2. AAR2 and BRR2 compete for PRP8 binding, and during U5 snRNP maturation BRR2 displaces the initially bound AAR2. Is associated with snRNP U5, together with SNU114 and BRR2.
messages: Contains a region with structural similarity to RNase H, but lacks RNase H activity.
messages: Contains a region with structural similarity to reverse transcripase, presenting the classical thumb, fingers and palm architecture, but lacks enzyme activity, since the essential metal-binding residues are not conserved.
messages: Contains a region with structural similarity to type-2 restriction endonucleases, but the residues that would bind catalytic metal ions in endonucleases are instead involved in hydrogen bonds that stabilize a highly conserved loop.
messages: Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for association of BRR2 with the spliceosomal U5 snRNP, and the subsequent assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site, as well as the branch region. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.
messages: Nucleus
messages: Present with 468 molecules/cell in log phase SD medium.
messages: The MPN (JAB/Mov34) domain has structural similarity with deubiquitinating enzymes, but lacks the residues that would bind the catalytic metal ion.

559292:YKL213C
gene id: 559292:YKL213C
uniprot id: P36037
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm
messages: Endosome membrane
messages: Forms a complex composed of CDC48, NPL4, UFD1, DOA1, SHP1 and deubiquitinase OTU1; within the complex interacts with CDC48 (PubMed:16427015). Interacts (via PUL domain) with CDC48 (via C-terminus); the interaction is direct (PubMed:8890162, PubMed:16427015, PubMed:16428438, PubMed:27044889, PubMed:19805280, PubMed:20508643). Forms a complex composed of CDC48, DOA1, deubiquitinase UBP3 and probably BRE5; within the complex interacts with CDC48 and UBP3 (PubMed:20508643). May form a complex composed of VPS27, HSE1 and DOA1 (PubMed:18508771). Interacts with HSE1 (via SH3 domain) (PubMed:18508771). Interacts (via WD repeats and PFU domain) with ubiquitin; the interaction is direct (PubMed:15096053, PubMed:16427015, PubMed:16428438, PubMed:21070969). Interacts with ubiquitinated FZO1 but not unmodified FZO1; the interaction recruits FZO1 to CDC48 and promotes FZO1 proteasomal degradation (PubMed:27044889).
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Present with 6800 molecules/cell in log phase SD medium.
messages: Severely reduces cell growth in response to misfolded protein, translation inhibition-induced, heat or mitochondrial oxidative stresses but not in response to ER stress (PubMed:16427015, PubMed:18508771, PubMed:16428438, PubMed:27044889).
messages: The PFU domain mediates interaction with ubiquitin.
messages: The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with CDC48 C-terminus.
messages: The WD repeats mediate interaction with ubiquitin.
messages: Ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation (PubMed:2111732, PubMed:8890162, PubMed:19805280, PubMed:18508771, PubMed:20508643, PubMed:27044889). Acts as a ubiquitinated substrate-recruiting adapter for chaperone ATPase CDC48 by binding mono- or polyubiquitin chains (PubMed:15096053, PubMed:16427015, PubMed:16428438, PubMed:27044889). Depending on the context, promotes or prevents proteasomal degradation of ubiquitinated proteins (PubMed:2111732, PubMed:8890162, PubMed:19805280, PubMed:27044889). Involved in the ubiquitin fusion degradation (UFD) pathway by promoting the degradation of ubiquitinated proteins (PubMed:2111732, PubMed:8890162, PubMed:19805280, PubMed:27044889). Involved in the mitochondria-associated degradation pathway (MAD) by promoting the degradation of several ubiquitinated membrane proteins (PubMed:27044889). By competing with UFD2 to bind CDC48, prevents the multi-ubiquitination and subsequent degradation of UFD2-dependent substrates (PubMed:16427015). Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation (PubMed:20508643). Involved in the ubiquitin-mediated sorting of membrane proteins into multivesicular bodies (MVBs) (PubMed:18508771). In addition, plays an essential role in maintaining cellular ubiquitin levels (PubMed:7615550, PubMed:16427015, PubMed:16428438, PubMed:18508771, PubMed:19805280). May affect indirectly the degradation of ubiquitinylated proteins by regulating cellular ubiquitin levels (PubMed:7615550, PubMed:23525333).

559292:YLL006W-A
gene id: 559292:YLL006W-A
uniprot id: Q3E814
names: Subcellular Location Annotation
messages: Membrane

559292:YIR030C
gene id: 559292:YIR030C
uniprot id: P32460
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the HyuE racemase family.
messages: Expression is regulated by various nitrogen sources.
messages: Sensitive to nitrogen catabolite repression.

559292:YBR205W
gene id: 559292:YBR205W
uniprot id: P38130
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 15 family.
messages: Interacts with SVP26.
messages: Membrane
messages: Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YGR189C
gene id: 559292:YGR189C
uniprot id: P53301
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.
messages: Membrane
messages: Positively regulated by cell integrity signaling through MPK1 in response to cell wall perturbation. Induced by heat stress.
messages: Present with 44000 wall-bound molecules/cell in log phase YPD medium.
messages: Probable glycosidase that plays a role in cell wall architecture. Required for the transfer of chitin to 1,6-beta-glucan in the cell wall.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YGR255C
gene id: 559292:YGR255C
uniprot id: P53318
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Based on current literature, utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals where only C5 hydroxylation of HHB has been shown, even if human COQ6 is able to perform the deamination reaction in the absence of COQ9.
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6 (PubMed:21944752). Can also convert 3-hexaprenyl-4-aminobenzoic acid (HAB), a COQ2-prenylated pABA, to DHHB in a two step process. HAB is first hydroxylated at C5 to yield 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) which is further deaminated at C4 by COQ6 to produce DHHB (PubMed:26260787).
messages: Mitochondrion inner membrane
messages: Present with 2940 molecules/cell in log phase SD medium.

559292:YOR382W
gene id: 559292:YOR382W
uniprot id: Q08906
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: By iron.
messages: Involved in the uptake of non-siderophore and siderophore sources of iron. Has a role in the retention of iron in the cell wall and periplasmic space.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YPL279C
gene id: 559292:YPL279C
uniprot id: Q08991
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride exporter Fluc/FEX family.
messages: Cell membrane
messages: Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
messages: Highly sensible to fluoride, but not to other halide salts. The growth of a double deletion of both FEX1 and FEX2 is inhibited at almost a 1000-fold lower fluoride concentration than in the wild-type. Has increased intracellular fluoride concentrations.
messages: Present with 220 molecules/cell in the plasma membrane.

559292:YPR185W
gene id: 559292:YPR185W
uniprot id: Q06628
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (PubMed:10995454, PubMed:11086004, PubMed:15743910, PubMed:17295840, PubMed:18077553, PubMed:18287526, PubMed:19805182, PubMed:19995911, PubMed:20647741, PubMed:20855505, PubMed:22447937, PubMed:22778255, PubMed:22782902, PubMed:22885598, PubMed:8224160, PubMed:21468027). Required for autophosphorylation of ATG1 at 'Thr-226' and its dimerization (PubMed:20439775, PubMed:17699586, PubMed:21712380). May also be involved in the regulation of autophagy through SNF1 (PubMed:11486014). Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure (PubMed:14723849, PubMed:17426440). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (PubMed:10837477). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (PubMed:10837477). Finally, ATG13 is also required for glycogen storage during stationary phase (PubMed:11486014).
messages: Belongs to the ATG13 family. Fungi subfamily.
messages: Cytoplasm
messages: Hypophosphorylated form interacts with ATG1 to form the ATG1-ATG13 kinase complex (PubMed:10995454, PubMed:15743910, PubMed:15901835, PubMed:18829864, PubMed:20439775, PubMed:20953146, PubMed:21712380, PubMed:22778255, PubMed:22885598). The ATG1-ATG13 complex interacts with the ATG17-ATG29-ATG31 complex through direct interaction with ATG17 (PubMed:23219485, PubMed:15743910, PubMed:15901835, PubMed:19755117, PubMed:19805182). Interacts with VAC8 (PubMed:10837477).
messages: Phosphorylated; hyperphosphorylated by the TORC1 kinase complex to repress the induction of autophagy in nutrient-replete conditions (PubMed:10995454, PubMed:19995911, PubMed:19805182, PubMed:22447937, PubMed:22727621, PubMed:29698392). Starvation and TOR inactivation results in ATG13 partial dephosphorylation leading to ATG1-binding (PubMed:10995454). Rephosphorylated by ATG1 during prolonged nitrogen starvation (PubMed:21490424). Also phosphorylated by PKA (PubMed:17699586, PubMed:19805182, PubMed:21078689). PKA phosphorylation regulates the association of ATG13 with the PAS (PubMed:21900499). Within this regulatory network, mitochondrial respiratory deficiency suppresses autophagic flux (PubMed:21468027). Hyperphosphorylation in rich medium is impaired in the absence of VAC8 (PubMed:10837477). Dephosphorylation is dependent on FAR11 (PubMed:22782902).
messages: Preautophagosomal structure
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YLR152C
gene id: 559292:YLR152C
uniprot id: P54072
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Membrane

559292:YJR075W
gene id: 559292:YJR075W
uniprot id: P47124
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 32 family.
messages: Component of the M-Pol II complex composed of ANP1, MNN9, MNN10, MNN11 and HOC1.
messages: Present with 7160 molecules/cell in log phase SD medium.
messages: The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.
messages: cis-Golgi network membrane

559292:YHR049W
gene id: 559292:YHR049W
uniprot id: P38777
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase 3 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 14600 molecules/cell in log phase SD medium.
messages: Serine hydrolase of unknown specificity.

559292:YOL044W
gene id: 559292:YOL044W
uniprot id: Q08215
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with PEX6 (PubMed:12808025). Interacts with PEX19; targets PEX15 to the peroxisome (PubMed:16763195).
messages: Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed:12808025, PubMed:9405362, PubMed:16007078). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed:12808025, PubMed:9405362).
messages: Peroxisome membrane
messages: Phosphorylated.
messages: Present with 1070 molecules/cell in log phase SD medium.

559292:YKL114C
gene id: 559292:YKL114C
uniprot id: P22936
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. APN1 accounts for > 97% of both apurinic/apyrimidinic (AP) endonuclease and DNA 3'-repair diesterase activities.
messages: Monomer.
messages: Nucleus
messages: Present with 7250 molecules/cell in log phase SD medium.

559292:YML018C
gene id: 559292:YML018C
uniprot id: Q03730
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family.
messages: Present with 2010 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YJR089W
gene id: 559292:YJR089W
uniprot id: P47134
names: Function
names: Subunit
messages: Seems to act in the pleiotropic control of cell division. May participate in chromosome segregation events.
messages: Strongly interacts with CBF2/NDC10. Also interacts with CBF3D/SKP1.

559292:YGL135W
gene id: 559292:YGL135W
uniprot id: P0CX43
uniprot id: P0CX44
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL1 forms part of the L1 stalk (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 116000 molecules/cell in log phase SD medium.
messages: Present with 265000 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL1 in yeast.

559292:YBR042C
gene id: 559292:YBR042C
uniprot id: P38226
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase with lysophosphatidic acid acyltransferase (LPAAT) activity. Fatty acyl substrates include 18:0-acyl-CoA, 16:0-acyl-CoA, 17:0-acyl-CoA and 14:0-acyl-CoA (PubMed:20694142). Responsible for the acyl-CoA-dependent introduction of saturated very long chain fatty acids (VLCFAs) into phosphatidylinositol, transferring saturated FAs with 18 to 26 carbon atoms (PubMed:27462707). Responsible for the incorporation of stearate into phosphatidylinositol (PubMed:19796168, PubMed:26711260). Overexpression has an effect on chromosome stability (PubMed:10454593). Regulates phosphorylation and expression of glycerol-3-phosphate acyltransferase SCT1 (PubMed:22323296).
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Lipid droplet
messages: Phosphoinositides (PIPs) with stearic acyl chains are strongly disturbed. Induces disturbances in intracellular trafficking, alterations in the budding pattern and defects in actin cytoskeleton organization.
messages: Present with 2010 molecules/cell in log phase SD medium.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

559292:YEL068C
gene id: 559292:YEL068C
uniprot id: P39977
names: Miscellaneous
messages: Present with 952 molecules/cell in log phase SD medium.

559292:YER142C
gene id: 559292:YER142C
uniprot id: P22134
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkylbase DNA glycosidase AlkA family.
messages: By DNA damage.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.
messages: Nucleus

559292:YDL074C
gene id: 559292:YDL074C
uniprot id: Q07457
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis.
messages: Forms a complex with the E2 enzyme RAD6/UBC2. May interact with LGE1.
messages: Nucleus
messages: Present with 2980 molecules/cell in log phase SD medium.

559292:YDR098C-A
gene id: 559292:YDR098C-A
uniprot id: Q03856
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YNR036C
gene id: 559292:YNR036C
uniprot id: P53732
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). uS12m is required for respiratory growth (PubMed:11780787).
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uS12m forms part of the decoding center of the mt-SSU.
messages: Mitochondrion
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YPL130W
gene id: 559292:YPL130W
uniprot id: Q03029
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Expressed in late pachytene.
messages: Involved in sporulation. Essential for completion of the nuclear division.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

559292:YIL087C
gene id: 559292:YIL087C
uniprot id: P40502
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM19 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion membrane

559292:YPR017C
gene id: 559292:YPR017C
uniprot id: P32601
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the DSS4/MSS4 family.
messages: Guanine-nucleotide-releasing protein that acts on SEC4. Might play a general role in vesicular transport.
messages: Present with 1500 molecules/cell in log phase SD medium.

559292:YBR058C-A
gene id: 559292:YBR058C-A
uniprot id: Q3E790
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with the serine palmitoyltransferase complex LCB1-LCB2. Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3.
messages: Stimulates the activity of serine palmitoyltransferase (SPT).

559292:YHR086W
gene id: 559292:YHR086W
uniprot id: Q00539
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subunit
messages: Affects the meiotic recombination and the formation of viable spores.
messages: Component of the U1 small nuclear ribonucleoprotein complex (U1 snRNP) involved in the initiation of meiotic recombination (PubMed:1603056, PubMed:7625279). Involved in the formation of DSBs at recombination hot-spots through meiosis-specific splicing of REC107 pre-mRNA (PubMed:7625279, PubMed:9112441, PubMed:21788335). Collaborates with MER1 to promote splicing of essential meiotic mRNAs REC10, AMA1, MER3, HFM1, SPO22 and PCH2 (PubMed:10983980, PubMed:21208980, PubMed:21788335). NAM8 interacts with the pre-mRNA downstream of the 5' splice site, in a region of non-conserved sequence and is required for efficient splicing of uncapped RNA precursor (PubMed:10072385).
messages: Component of the U1 small nuclear ribonucleoprotein complex (U1 snRNP).
messages: Present with 1480 molecules/cell in log phase SD medium.
messages: The RNA binding domains RRM2 and RRM3 are required for NAM8 meiotic function (PubMed:21788335, PubMed:21208980). Within the U1 snRNP complex, the RRM2 domain of NAM8 is positioned to bind to the intronic region immediately down-stream of nucleotide +13 (PubMed:31485080).

559292:YOR075W
gene id: 559292:YOR075W
uniprot id: P41834
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Component of a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6.
messages: Endoplasmic reticulum membrane
messages: Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

559292:YGL029W
gene id: 559292:YGL029W
uniprot id: P53188
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CGR1 family.
messages: In response to cytotoxic stress but not genotoxic stress.
messages: Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
messages: Present with 2340 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YPR125W
gene id: 559292:YPR125W
uniprot id: Q06493
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosomes.
messages: Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation.
messages: Mitochondrion inner membrane
messages: Present with 11300 molecules/cell in log phase SD medium.

559292:YDR408C
gene id: 559292:YDR408C
uniprot id: P04161
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the GART family.
messages: Induced by amino acid and purine starvation in a GCN4 dependent manner.
messages: Present with 3910 molecules/cell in log phase SD medium.

559292:YNL263C
gene id: 559292:YNL263C
uniprot id: P53845
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YIF1 family.
messages: COPII-coated vesicle
messages: Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1. The complex interacts with the ER to Golgi SNAREs BOS1 and SEC22. Interacts with the YIP1 family members YIP4 and YIP5, and with the Rab GTPases SEC4, YPT1, YPT6, YPT7, YPT10, YPT11, YPT31, YPT32 and YPT52. Interacts with BTN2 and SNX3.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases.

559292:YNR038W
gene id: 559292:YNR038W
uniprot id: P53734
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Associated with pre-ribosomal particles. Interacts with DBP9 and RSA3. Together with NOP8, URB1, URB2 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.
messages: Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
messages: Present with 12700 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YPL013C
gene id: 559292:YPL013C
uniprot id: Q02608
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS16 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion

559292:YDR062W
gene id: 559292:YDR062W
uniprot id: P40970
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalytic subunit of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: LCB1 and LCB2 encode essential subunits of the enzyme and form a heterodimer. Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. Interacts with LCB1 and TSC3.
messages: Membrane
messages: Present with 54500 molecules/cell in log phase SD medium.

559292:YHR010W
gene id: 559292:YHR010W
uniprot id: P0C2H6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 7380 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL27 in yeast.

559292:YBR110W
gene id: 559292:YBR110W
uniprot id: P16661
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer. Interacts with ALG2 and ALG11.
messages: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
messages: Present with 1890 molecules/cell in log phase SD medium.

559292:YOR132W
gene id: 559292:YOR132W
uniprot id: P32913
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS17 family.
messages: Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPS5 and VPS17.
messages: Endomembrane system
messages: Phosphorylated on one or more serine residues.
messages: Plays a role in vesicular protein sorting. Required for the sorting and delivery of a subset of soluble vacuolar hydrolases. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.
messages: Present with 7380 molecules/cell in log phase SD medium.

559292:YGR181W
gene id: 559292:YGR181W
uniprot id: P53299
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins under precise conditions while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins. Strictly required for import of TIM23 in some conditions, when a low membrane potential exists in the mitochondria.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.

559292:YPL088W
gene id: 559292:YPL088W
uniprot id: Q02895
names: Function
names: Induction
names: Similarity
messages: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
messages: By cell wall stress and the YRR1 transcription factor.
messages: Putative aryl-alcohol dehydrogenase.

559292:YJL192C
gene id: 559292:YJL192C
uniprot id: P39543
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SOP4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles.
messages: Present with 11700 molecules/cell in log phase SD medium.

559292:YML074C
gene id: 559292:YML074C
uniprot id: P38911
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
messages: Inhibited by both FK506 and rapamycin.
messages: Interacts with NOP53.
messages: Phosphorylated at tyrosine and dephosphorylated by the phosphotyrosine-specific phosphoprotein phosphatase PTP1.
messages: Present with 9490 molecules/cell in log phase SD medium.
messages: Proline isomerase that belongs to an abundant class of enzymes that catalyze the cis-trans isomerization of X-Pro peptide bonds and can accelerate the refolding of proline-containing polypeptides (PubMed:7925954, PubMed:8051210, PubMed:7525596). Specifically binds nuclear localization sequences (PubMed:7925954). May be involved in the assembly or folding of ribosomal proteins (PubMed:8051210).
messages: nucleolus

559292:YLR001C
gene id: 559292:YLR001C
uniprot id: Q07895
names: Miscellaneous
names: Subcellular Location Annotation
messages: Present with 206 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YOR349W
gene id: 559292:YOR349W
uniprot id: P40987
names: Function
names: Miscellaneous
messages: Present with 704 molecules/cell in log phase SD medium.
messages: Required for microtubule stability. Interacts with CIN4.

559292:YFL036W
gene id: 559292:YFL036W
uniprot id: P13433
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Mitochondrion

559292:YGL194C-A
gene id: 559292:YGL194C-A
uniprot id: Q2V2P6
names: Subcellular Location Annotation
messages: Membrane

559292:YOR032W-A
gene id: 559292:YOR032W-A
uniprot id: Q8TGS1
names: Subcellular Location Annotation
messages: Membrane

559292:YGR246C
gene id: 559292:YGR246C
uniprot id: P29056
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIB family.
messages: General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.
messages: Nucleus
messages: Present with 4330 molecules/cell in log phase SD medium.
messages: TFIIIB comprises the TATA-binding protein (TBP), the B-related factor (BRF) and the B' component (TFC5).

559292:YHR085W
gene id: 559292:YHR085W
uniprot id: P38803
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus
messages: Present with 4420 molecules/cell in log phase SD medium.

559292:YDR055W
gene id: 559292:YDR055W
uniprot id: Q12355
names: Biotechnology
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Extensively N- and O-mannosylated.
messages: Has a partially redundant function to ECM33 in cell wall integrity. May be involved in a repair mechanism activated in response to cell wall damage.
messages: Mannoprotein called haze protective factor from wine that is able to prevent visible wine protein haze formation. This mannoprotein showed haze-protective activity against wine proteins and BSA when either was heated in white wine.
messages: Positively regulated by cell integrity signaling through MPK1 in response to cell wall perturbation. Induction is dependent on transcription factor RLM1.
messages: Present with 11700 molecules/cell in log phase SD medium.
messages: cell wall

559292:YOL083W
gene id: 559292:YOL083W
uniprot id: Q12292
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.
messages: Interacts with AMS1, ATG8 and ATG11.
messages: Preautophagosomal structure membrane

559292:YLR222C
gene id: 559292:YLR222C
uniprot id: Q05946
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: Present with 8070 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR259C
gene id: 559292:YDR259C
uniprot id: Q03935
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. YAP subfamily.
messages: Homodimer.
messages: Nucleus
messages: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
messages: Present with 1400 molecules/cell in log phase SD medium.
messages: Seems to activate its own expression and that of the repressor ROX1 which in turn represses YAP6 expression.
messages: Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, protein synthesis, carbohydrate metabolism, and carbohydrate transport. It may also be involved in pleiotropic drug resistance. When overexpressed, it confers resistance to cisplatin, methylmethanosulfonate, and mitomycin C, and increases cellular tolerance to sodium and lithium.

559292:YGL030W
gene id: 559292:YGL030W
uniprot id: P14120
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL30 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 59300 molecules/cell in log phase SD medium.

559292:YOL020W
gene id: 559292:YOL020W
uniprot id: P38967
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane
messages: Present with 752 molecules/cell in log phase SD medium.
messages: Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine.

559292:YAL049C
gene id: 559292:YAL049C
uniprot id: P39721
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM2 family.
messages: Cytoplasm
messages: Present with 1800 molecules/cell in log phase SD medium.

559292:YCL068C
gene id: 559292:YCL068C
uniprot id: P25593
names: Caution
messages: Could be the product of a pseudogene. Almost identical to BUD5 N-terminal.

559292:YKL025C
gene id: 559292:YKL025C
uniprot id: P36102
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate (PubMed:24880344). However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs (By similarity).
messages: Cytoplasm
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.
messages: Phosphorylated by the cyclin-CDK complex PCL1-PHO85.
messages: Present with 1600 molecules/cell in log phase SD medium.
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

559292:YBL055C
gene id: 559292:YBL055C
uniprot id: P34220
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
messages: Cytoplasm
messages: Divalent metal cations. Has optimal activity with Mg(2+).
messages: Has both endo- and exonuclease activities. Incises double-stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity. May have a role in apoptosis.
messages: Present with 1460 molecules/cell in log phase SD medium.

559292:YNL001W
gene id: 559292:YNL001W
uniprot id: P33309
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: Involved in protein translation. Together with HBS1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by DOM34 and HBS1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of HBS1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions.
messages: Monomer. Interacts with HBS1.
messages: Present with 1720 molecules/cell in log phase SD medium.
messages: The N-terminal domain has the RNA-binding Sm fold (PubMed:18180287). It harbors the endoribonuclease activity (PubMed:17889667).

559292:YOR083W
gene id: 559292:YOR083W
uniprot id: Q12416
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WHI5/NRM1 family.
messages: By transcription factor HCM1 during S phase.
messages: Cytoplasm
messages: Interacts with the heterodimeric transcription factors SBF (SWI4-SWI6 cell-cycle box binding factor) and MBF (MluI cell-cycle box binding factor), each composed of the transcriptional coactivator SWI6 and a sequence-specific DNA-binding protein SWI4 or MBP1, respectively.
messages: Nucleus
messages: Phosphorylation by the cyclin-dependent kinase (CDK) CDC28 controls both subcellular location and association of WHI5 with SBF.
messages: Present with 1440 molecules/cell in log phase SD medium.
messages: Transcriptional repressor that negatively regulates G1-specific, SBF- and MBF-dependent transcription. Binds via SBF to promoters of G1-specific genes to repress transcription in early G1. During G1, phosphorylated by cyclin-CDK CLN3-CDC28 and progressively hyperphosphorylated by CDK associated with other G1-cyclins, which leads to dissociation of WHI5 from SBF, activating SBF-dependent transcription in late G1. Elimination of CDK activity at the end of mitosis by the mitotic exit network (MEN) allows WHI5 to reassociate with SBF to again repress G1/S transcription.

559292:YNL189W
gene id: 559292:YNL189W
uniprot id: Q02821
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin alpha family.
messages: Binds to nucleoporin FxFG but not GLFG repeat regions. Ran-GTP can disrupt the karyopherin heterodimer by binding to the beta subunit and releases both subunits from the docking site.
messages: Forms a complex with an importin beta subunit. In the nucleus, interacts with NUP2 which accelerate release of NLSs, NUP2 is subsequently displaced by CSE1:RanGTP which mediates re-export and recycling. Interacts with HEH2, SHE2, and STS1.
messages: Functions in nuclear protein import as an adapter protein for importin beta nuclear receptors (PubMed:10913188). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:10745017). Promotes docking of import substrates to the nuclear envelope (PubMed:8521485). Together with importin beta KAP95, mediates nuclear import of transcription factor GCN4 (PubMed:14648200). Together with tethering factor STS1, targets the proteasome to the nucleus (PubMed:10913188, PubMed:21075847).
messages: Present with 2790 molecules/cell in log phase SD medium.
messages: The NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding.
messages: perinuclear region

559292:YDR451C
gene id: 559292:YDR451C
uniprot id: Q04116
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Expressed during late S phase and G2 phases.
messages: Interacts with MCM1.
messages: May be regulated by MCM1. Regulated by SWI4-SWI6 heterodimer. Down-regulated by nonfermentable carbon source.
messages: Nucleus
messages: Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during S late phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Binds the IMEI regulatory region in vitro, its relevance in vivo is however unclear.

559292:YFL017C
gene id: 559292:YFL017C
uniprot id: P43577
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.
messages: Present with 2550 molecules/cell in log phase SD medium.

559292:YKL008C
gene id: 559292:YKL008C
uniprot id: P28496
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Component of the ceramide synthase complex that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward hexacosanoyl-CoA (C26:0-CoA) (PubMed:15692566, PubMed:11694577). N-acylates sphinganine and phytosphingosine bases to form dihydroceramides and phytoceramides, respectively (PubMed:15692566, PubMed:11694577). Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins.
messages: Composed of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.
messages: Endoplasmic reticulum membrane
messages: Expression is controlled by PDR1 and PDR3 which bind its propmoter PDRE element, and by ROX1 and CBF1.
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YDR201W
gene id: 559292:YDR201W
uniprot id: Q03954
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex SPC19 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: Present with 639 molecules/cell in log phase SD medium.
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle

559292:YNL194C
gene id: 559292:YNL194C
uniprot id: P40169
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUR7 family.
messages: Cell membrane
messages: Involved in sporulation and affects the sphingolipid composition of the plasma membrane.

559292:YMR278W
gene id: 559292:YMR278W
uniprot id: Q03262
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hyperaccumulates ribose 1-phosphate and upstream purines upon glucose-induced purine nucleoside recycling.
messages: Major phosphoribomutase that converts ribose 1-phosphate to ribose 5-phosphate. Involved in ribose salvage via the pentose phosphate pathway.
messages: Nucleus
messages: Present with 4960 molecules/cell in log phase SD medium.

559292:YPL134C
gene id: 559292:YPL134C
uniprot id: Q03028
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Present with 2840 molecules/cell in log phase SD medium.
messages: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.

559292:YDR447C
gene id: 559292:YDR447C
uniprot id: P14127
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 30500 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS17 in yeast.

559292:YJL079C
gene id: 559292:YJL079C
uniprot id: P47032
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: O-glycosylated.
messages: Present with 556 molecules/cell in log phase SD medium.
messages: Secreted
messages: Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.
messages: The SCP domain is necessary and sufficient for lipid export and sterol-binding.

559292:YOR124C
gene id: 559292:YOR124C
uniprot id: Q01476
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Forms a ternary complex with RSP5 and RUP1 (PubMed:15933713). Interacts with RSP5 (PubMed:19920177). Interacts with FZO1 (PubMed:23317502).
messages: Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin (PubMed:15933713). Hydrolyzes polyubiquitinated 'Lys-63' polyubiquitin chains in RPO21, producing mono-ubiquitinated RNA polymerase II (PubMed:19920177). Removes ubiquitin chains that initiate proteolysis of FZO1 and inhibit mitochondrial fusion (PubMed:23317502).
messages: Increases the amount of polyubiquitinated RNA polymerase II subunit RPO21.
messages: Present with 2420 molecules/cell in log phase SD medium.

559292:Q0105
gene id: 559292:Q0105
uniprot id: P00163
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently per subunit.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:8031140, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). Cytochrome b is a catalytic core subunit containing 2 b-type hemes BL and BH topographically segregated in the quinone reduction (Qi) and quinol oxidation (Q0) sites on opposite sides of the membrane (PubMed:18390544).
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Mitochondrion inner membrane

559292:YDR403W
gene id: 559292:YDR403W
uniprot id: P21623
names: Developmental Stage
names: Function
messages: Involved in spore wall maturation. Catalyzes a two step reaction that leads to the LL-dityrosine containing precursor of the spore wall.
messages: Sporulation.

559292:YGL022W
gene id: 559292:YGL022W
uniprot id: P39007
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STT3 family.
messages: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:12359722). This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (PubMed:29301962).
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:10677492, PubMed:16297388, PubMed:16096345, PubMed:15831493, PubMed:15886282, PubMed:9405463, PubMed:9435788, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962). Interacts with SEC61 (PubMed:15831493).
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Endoplasmic reticulum membrane
messages: Present with 3000 molecules/cell in log phase SD medium.

559292:YDL015C
gene id: 559292:YDL015C
uniprot id: Q99190
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the steroid 5-alpha reductase family.
messages: Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. VLCFAs serve for instance as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress.
messages: Endoplasmic reticulum membrane
messages: Interacts with the fatty acid elongation system components ELO2 and ELO3. Interacts with NVJ1.
messages: Present with 23600 molecules/cell in log phase SD medium.

559292:YKL107W
gene id: 559292:YKL107W
uniprot id: P34251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmrA-type oxidoreductase family.
messages: Membrane

559292:YJL047C
gene id: 559292:YJL047C
uniprot id: P47050
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cullin family.
messages: Component of multiple cullin-RING ligases (CRLs) composed of 4 subunits: the RING protein HRT1, the cullin RTT101, a linker protein MMS1, and one of many alternative substrate receptors belonging to a protein family described as DCAF (DDB1- and CUL4-associated factor). Component of a RTT101(MMS1-MMS22) complex with the substrate receptor MMS22. This complex further interacts with RTT107 and CTF4 to form RTT101-MMS1-MMS22-RTT107 and RTT101-MMS1-MMS22-CTF4 complexes respectively. Component of a RTT101(MSS1-CRT10) complex with the substrate receptor CRT10. Component of a RTT101(MSS1-ESC2) complex with the potential substrate receptor ESC2. Component of a RTT101(MSS1-ORC5) complex with the potential substrate receptor ORC5. Interacts (via C-ter) with HRT1; required for ubiquitin-ligase activity. Interacts (via N-ter) with MMS1.
messages: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Ubiquitinates the FACT (facilitates chromatin transcription) complex subunit SPT16 in an MMS1-independent manner. Involved in regulation of Ty1 transposition and protects the genome from Ty1 integration upstream of tRNA genes.
messages: Cytoplasm
messages: Delays anaphase progression.
messages: Neddylated. HRT1-binding is necessary for RUB1/NEDD8 modification of RTT101. The modification enhances ubiquitin-ligase activity.
messages: Nucleus

559292:YNL260C
gene id: 559292:YNL260C
uniprot id: P53846
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTO1 family.
messages: Essential for life in oxygen, but nonessential under anaerobic conditions. Required for biogenesis of the large ribosomal subunit and initiation of translation in oxygen (PubMed:23318452). The complex LTO1:YAE1 functions as a target specific adapter that recruits apo-RLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403).
messages: Forms a complex with YAE1; the complex bridges the interaction between the CIA complex and RLI1 (PubMed:23318452). Associates with the CIA complex (via its C-terminal tryptophan) (PubMed:26182403).
messages: Nucleus
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YGR027C
gene id: 559292:YGR027C
uniprot id: Q3E792
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: It is presumed that the precursor part of S25 is engaged in assembling of the small subunit, thus being essential in ribosome maturation.
messages: Present with 322000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS25 in yeast.

559292:YLL043W
gene id: 559292:YLL043W
uniprot id: P23900
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Leu-Ala/Ser (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions.
messages: Membrane
messages: Present with 907 molecules/cell in log phase SD medium.

559292:YJR097W
gene id: 559292:YJR097W
uniprot id: P47138
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DPH4 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2010 molecules/cell in log phase SD medium.
messages: Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.
messages: Resistance to sordarin and zymocin.
messages: The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

559292:YKR085C
gene id: 559292:YKR085C
uniprot id: P22354
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL58 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 350 molecules/cell in log phase SD medium.

559292:YMR293C
gene id: 559292:YMR293C
uniprot id: Q03557
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling.
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Present with 486 molecules/cell in log phase SD medium.
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A (HER2), B (PET112) and F (YGR102C) subunits.

559292:YFL066C
gene id: 559292:YFL066C
uniprot id: P43538
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YLR288C
gene id: 559292:YLR288C
uniprot id: Q02574
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MEC3 family.
messages: Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17. The interaction with MEC3 is performed in a RAD17-dependent manner. The checkpoint clamp complex loads onto DNA. Interacts with the DNA polymerase zeta subunit REV7. Forms also a heterotrimer with 2 RAD17 subunits. Interacts with SET1.
messages: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA.
messages: Nucleus
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YDR216W
gene id: 559292:YDR216W
uniprot id: P07248
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Nucleus
messages: Phosphorylation at Ser-230 by cAMP-dependent protein kinase A does not affect DNA binding but appears to prevent transcription of ADH2 during glucose repression.
messages: Required for transcriptional activation of glucose-repressible alcohol dehydrogenase (ADH2).

559292:YGR049W
gene id: 559292:YGR049W
uniprot id: P32564
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG33 family.
messages: Membrane
messages: Present with 3210 molecules/cell in log phase SD medium.

559292:YNL297C
gene id: 559292:YNL297C
uniprot id: P48563
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MON2 family.
messages: Golgi apparatus membrane
messages: Homodimer. Interacts with DOP1, ARL1 and NEO1.
messages: Present with 2410 molecules/cell in log phase SD medium.
messages: Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure.

559292:YGR266W
gene id: 559292:YGR266W
uniprot id: P53326
names: Miscellaneous
messages: Present with 3230 molecules/cell in log phase SD medium.

559292:YML093W
gene id: 559292:YML093W
uniprot id: Q04500
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP14 family.
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: Present with 1470 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR291W
gene id: 559292:YDR291W
uniprot id: Q05549
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. HRQ1 subfamily.
messages: By heat shock.
messages: Forms heptamer rings (PubMed:24440721). Interacts with RAD4 (PubMed:24682993).
messages: Helicase with 3'-5' helicase activity involved in genome stability (PubMed:23456718, PubMed:24440721, PubMed:24700328). Functions in the RAD4-dependent nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair (PubMed:24440721, PubMed:24682993). Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA (PubMed:23026052). Activity is significantly stimulated by a preexisting fork structure (PubMed:24682993). Shows both processive helicase and DNA strand annealing activities (PubMed:24682993). Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding (PubMed:24440721).
messages: Leads to increased mitotic recombination and spontaneous mutation, as well as to sensitivity to 4-nitroquinoline 1-oxide and cisplatin (PubMed:23456718). Causes also hypersensitivity to DNA interstrand cross-links (ICLs) and telomere addition to DNA breaks (PubMed:24440721).
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YMR299C
gene id: 559292:YMR299C
uniprot id: Q04949
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light intermediate chain DYN3 family.
messages: Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.
messages: Present with 1170 molecules/cell in log phase SD medium.
messages: The dynein complex consists of at least two heavy chains and a number of intermediate and light chains. Interacts with DYN1.
messages: cytoskeleton

559292:YKL152C
gene id: 559292:YKL152C
uniprot id: P00950
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Cytoplasm
messages: Homotetramer: dimer of dimers.
messages: Inhibited by inositol hexakisphosphate and benzene tri-, tetra- and hexacarboxylates.
messages: Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also Catalyzes the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: Present with 172000 molecules/cell in log phase SD medium.

559292:YHR040W
gene id: 559292:YHR040W
uniprot id: P38772
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCD1 family.
messages: Nucleus
messages: Present with 2800 molecules/cell in log phase SD medium.
messages: Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

559292:YJL051W
gene id: 559292:YJL051W
uniprot id: P47046
names: Subcellular Location Annotation
messages: Membrane

559292:YPL126W
gene id: 559292:YPL126W
uniprot id: Q02931
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
messages: Present with 6560 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YIL101C
gene id: 559292:YIL101C
uniprot id: P40489
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: By heat shock, high osmolarity, oxidative stress, DNA damage and glucose starvation.
messages: Nucleus
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Transcriptional repressor which binds to the consensus sequence 5'-GCCTCGA[G/A]G[C/A]-3'. Represses CLN1 transcription.

559292:YFR011C
gene id: 559292:YFR011C
uniprot id: P43594
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic19 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.
messages: Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.
messages: Mitochondrion inner membrane
messages: Present with 3550 molecules/cell in log phase SD medium.

559292:YML075C
gene id: 559292:YML075C
uniprot id: P12683
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway constitutes by the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:3065625, PubMed:3526336). HMG1 and HMG2 catalyze the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate that is the rate-limiting step within the first mosule (PubMed:3526336). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672).
messages: Nucleus envelope
messages: The sterol-sensing domain (SSD) is required for sterol pathway signals to stimulate hmg2 ER-associated degradation and detects both geranylgeranyl pyrophosphate and a secondary oxysterol signal.
messages: When both HMG1 and HMG2 are deleted, cells are unable to undergo spore germination and vegetative growth.

559292:YER048W-A
gene id: 559292:YER048W-A
uniprot id: Q6Q560
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family.
messages: Interacts with NFS1.
messages: Mitochondrion
messages: Present with 2440 molecules/cell in log phase SD medium.
messages: Required for mitochondrial iron-sulfur proteins biosynthesis.

559292:YLR067C
gene id: 559292:YLR067C
uniprot id: P32522
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Present with 1160 molecules/cell in log phase SD medium.
messages: Required for initiation of translation of the COX1 coding region. Also involved in the stability of the intron containing transcript of COX1.

559292:YNL024C
gene id: 559292:YNL024C
uniprot id: P53970
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.
messages: Cytoplasm
messages: Present with 1760 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-390'.

559292:YLR301W
gene id: 559292:YLR301W
uniprot id: Q05905
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HRI1 family.
messages: Cytoplasm
messages: Interacts with HRR25. May interact with SEC72.
messages: Nucleus
messages: Present with 15400 molecules/cell in log phase SD medium.
messages: Unknown. Non essential.

559292:YBR295W
gene id: 559292:YBR295W
uniprot id: P38360
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although initial characterizations described PCA1 as a copper-transporting ATPase, subsequent experiments have demonstrated that PCA1 is capable of high affinity copper ion binding, but not active copper ion transport.
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cadmium transporting P-type ATPase which plays a critical role in cadmium resistance by extruding intracellular cadmium. Capable of high affinity copper ion binding, but not active copper ion transport. May play a role in copper resistance by chelating and sequestering copper ions.
messages: Cell membrane
messages: In the absence of cadmium, is ubiquitinated and targeted for degradation before reaching the plasma membrane. This allows a rapid and specific cellular response to cadmium.
messages: Strain S288C, as well as other laboratory cadmium-sensitive strains, contain a natural Gly-970-Arg mutation which eliminates cadmium transport function. Loss of cadmium resistance provides a fitness advantage under cadmium-free conditions.

559292:YAL005C
gene id: 559292:YAL005C
uniprot id: P10591
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds human HTN3/histatin-5, a peptide from saliva, and mediates its fungicidal activity. Interacts with polyadenylate-binding protein PAB1 and Hsp70 chaperone SSA1 on translating ribosomes. Interacts with NAP1.
messages: Cytoplasm
messages: May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA1 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.
messages: Present with 269000 molecules/cell in log phase SD medium.
messages: cell wall

559292:YPR034W
gene id: 559292:YPR034W
uniprot id: Q12406
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family.
messages: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in transcriptional regulation. Heterodimer of ARP7 and ARP9 functions with HMG box proteins to facilitate proper chromatin architecture. Heterodimer formation is necessary for assembly into RSC complex. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Forms a heterodimer with ARP9. Interacts with NPL6. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Nucleus
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YMR108W
gene id: 559292:YMR108W
uniprot id: P07342
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalytic subunit of mitochondrial acetolactate synthase, which catalyzes the first of a series of common steps in the biosynthesis of the branched-chain amino acids. Catalyzes the irreversible decarboxylation of pyruvate to a bound hydroxyethyl group that then condenses with either a second pyruvate molecule to form 2-acetolactate (AL) or with 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate (AHB). The first product is the precursor for valine and leucine biosynthesis, while the second leads to isoleucine.
messages: Contains 1 molecule of FAD per monomer. The role of this cofactor is not clear considering that the reaction does not involve redox chemistry.
messages: Homodimer. The acetolactate synthase complex contains the catalytic subunit ILV2 and the regulatory small subunit ILV6.
messages: Mitochondrion
messages: Present with 31900 molecules/cell in log phase SD medium.
messages: The regulatory subunit ILV6 stimulates enzymatic activity seven- to tenfold and confers sensitivity to inhibition by valine and activation by ATP.

559292:YER014W
gene id: 559292:YER014W
uniprot id: P40012
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane
messages: Present with 5350 molecules/cell in log phase SD medium.

559292:YMR152W
gene id: 559292:YMR152W
uniprot id: P28625
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIM1 family.
messages: Displays sensitivity to DNA damaging agents.
messages: Lipid droplet
messages: Mitochondrion
messages: Present with 6540 molecules/cell in log phase SD medium.

559292:YBR182C
gene id: 559292:YBR182C
uniprot id: P38128
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MEF2 family.
messages: Can heterodimerize with RLM1. Interacts with HOG1.
messages: Nucleus
messages: Phosphorylated by HOG1.
messages: Transcription factor that controls part of the HOG1-mediated osmostress responses. Binds to the DNA sequence 5'-ACTACTA[TA](4)TAG-3'. Does not appear to function in the MPK1 pathway.

559292:YEL017W
gene id: 559292:YEL017W
uniprot id: P39996
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus membrane
messages: Present with 1300 molecules/cell in log phase SD medium.

559292:YOR372C
gene id: 559292:YOR372C
uniprot id: Q08887
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: During S phase of the cell cycle. Expression is cell cycle regulated by HCM1.
messages: Forms an activator complex with FKH2.
messages: Nucleus
messages: Phosphorylation of Thr-319 by CDC28 is required for the interaction with FKH2 and recruitment to promoters.
messages: Present with 779 molecules/cell in log phase SD medium.
messages: Transcription activator involved in G2/M transcription through its association with FKH2.

559292:YKR010C
gene id: 559292:YKR010C
uniprot id: Q02208
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with HPR1.
messages: Nucleus
messages: Present with 339 molecules/cell in log phase SD medium.
messages: To yeast YJL076w.

559292:YJL117W
gene id: 559292:YJL117W
uniprot id: P46956
names: Function
names: Subcellular Location Annotation
messages: Involved in the uptake of inorganic phosphate.
messages: Membrane

559292:YEL022W
gene id: 559292:YEL022W
uniprot id: P39993
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in maintaining mitochondrial morphology (PubMed:25190516).
messages: Interacts with GMH1.
messages: Membrane
messages: Present with 7700 molecules/cell in log phase SD medium.
messages: cytosol

559292:YDR014W-A
gene id: 559292:YDR014W-A
uniprot id: Q03937
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Interacts with RAD51.
messages: Involved in regulation of meiotic recombination and repair of DNA damage. Inhibits RAD51-mediated recombination when the meiotic recombination machinery is impaired.
messages: Meiosis-specific.
messages: Nucleus

559292:YPL172C
gene id: 559292:YPL172C
uniprot id: P21592
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Mitochondrion membrane

559292:YMR208W
gene id: 559292:YMR208W
uniprot id: P07277
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Farnesyl pyrophosphate and geranyl pyrophosphate inhibit mevalonate kinase by binding competitively at the ATP-binding site.
messages: Homodimer.
messages: Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:1645230). ERG12 converts mevalonate into 5-phosphomevalonate (PubMed:1645230). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672).
messages: Present with 3300 molecules/cell in log phase SD medium.
messages: cytosol

559292:YGL166W
gene id: 559292:YGL166W
uniprot id: P15315
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 1760 molecules/cell in log phase SD medium.
messages: Trans-acting regulatory protein that activates transcription of the CUP1 gene (metallothionein) in response to copper ions. Binds to the CUP1 UAS sequence 5'-GCTTCTTTTCCGCTGA-3'. Binds DNA only in presence of copper or silver. Copper seems to alter the conformation of the protein.

559292:YIR007W
gene id: 559292:YIR007W
uniprot id: P40566
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
messages: Ergosteryl beta-glucosidase involved in the ergosteryl beta-glucoside (EG) catabolic pathway and vacuole formation via hydrolysis of EG to generate glucose (PubMed:26116408). Is also able to hydrolyze cholesteryl beta-glucoside and sitosteryl beta-glucoside to generate glucose; and C6-7-nitro-2,1,3-benzoxadiazole (NBD)-GlcCer to generate C6-NBD-ceramide (Cer) (PubMed:26116408).
messages: Present with 1070 molecules/cell in log phase SD medium.
messages: Resulted in the accumulation of ergosteryl beta-glucoside (EG) and fragmentation of vacuoles.
messages: Vacuole membrane
messages: cytosol

559292:YBR261C
gene id: 559292:YBR261C
uniprot id: P38340
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of the ribosomal proteins RPL12A, RPL12B, RPS25A and RPS25B.
messages: Belongs to the methyltransferase superfamily. NTM1 family.
messages: Cytoplasm
messages: Defects in both translation efficiency and fidelity.
messages: Present with 3060 molecules/cell in log phase SD medium.

559292:YOR174W
gene id: 559292:YOR174W
uniprot id: Q12343
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. MED4 interacts directly with MED1, MED7 and SRB7/MED21.
messages: Nucleus
messages: Present with 1617 molecules/cell in log phase SD medium.

559292:YNL116W
gene id: 559292:YNL116W
uniprot id: P53924
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMA1 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes. Involved in nutritional control of the cell cycle. Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck.
messages: Present with 1750 molecules/cell in log phase SD medium.
messages: UBC4-dependent autoubiquitination occurs at Lys-211, Lys-258, Lys-288, Lys-310, Lys-333, Lys-343, Lys-346, Lys-366, Lys-406, Lys-412 and Lys-423. UBC4-dependent autoubiquitination is responsible for DMA2 turnover. UBC13/MMS2-dependent autoubiquitination occurs at Lys-258, Lys-310, Lys-346 and Lys-366. Lys-211, Lys-256, Lys-288, Lys-310, Lys-343, Lys-258, Lys-366 and Lys-412 are also ubiquitinated in trans by DMA1 E3 ligase in association with UBC4.

559292:YPL036W
gene id: 559292:YPL036W
uniprot id: P19657
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
messages: There are two plasma membrane ATPases in yeast. This is the minor isoform.

559292:YIL004C
gene id: 559292:YIL004C
uniprot id: P22804
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BET1 family.
messages: Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with SEC24.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.

559292:YDR415C
gene id: 559292:YDR415C
uniprot id: Q04033
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M28 family. M28E subfamily.
messages: Binds 2 Zn(2+) ions per subunit.

559292:YJL100W
gene id: 559292:YJL100W
uniprot id: P42951
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Interacts with LAS17.
messages: May play a role in endocytic and/or exocytic pathways.
messages: Present with 56 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YDR073W
gene id: 559292:YDR073W
uniprot id: P38956
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Nucleus
messages: Present with 1030 molecules/cell in log phase SD medium.

559292:YNL294C
gene id: 559292:YNL294C
uniprot id: P48565
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palH/RIM21 family.
messages: Cell membrane
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity). Required for growth at alkaline pH.

559292:YLR332W
gene id: 559292:YLR332W
uniprot id: P36027
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MID2 like cell wall stress sensor family.
messages: Cell membrane
messages: Cell wall stress sensor. Involved in activation of a response that includes both stress-related increased chitin synthesis and the MPK1 mitogen-activated protein kinase cell integrity pathway. High-copy activator of the SKN7 transcription factor. Required during induction of MPK1 tyrosine phosphorylation under a variety of stress conditions. Required for PKC pathway activation under low pH conditions. Required for cell integrity signaling during pheromone-induced morphogenesis. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1 in cell wall integrity signaling.
messages: Interacts with ZEO1.
messages: O-mannosylated by PMT2.

559292:YPL087W
gene id: 559292:YPL087W
uniprot id: Q02896
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA-independent ceramide synthase that catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response.
messages: Belongs to the alkaline ceramidase family.
messages: Endoplasmic reticulum membrane

559292:YBL001C
gene id: 559292:YBL001C
uniprot id: P35195
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0045 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Nucleus
messages: Present with 1900 molecules/cell in log phase SD medium.

559292:YKL026C
gene id: 559292:YKL026C
uniprot id: P36014
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: By glucose starvation.
messages: Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress (PubMed:10480913, PubMed:11445588). Has peroxidase activity using thioredoxin or glutathione as a reducing power (PubMed:20572871, PubMed:22659048). Involved in peroxisome formation (PubMed:22659048).
messages: Impairs growth and peroxisome formation in oleic acid medium.
messages: Mitochondrion outer membrane
messages: Monomer.
messages: Peroxisome matrix
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide.
messages: Was originally thought to be a glutathione peroxidase (PubMed:10480913) or a phospholipid hydroperoxide glutathione peroxidase (PubMed:11445588), but functions as an atypical 2-Cys peroxiredoxin using both glutathione and thioredoxin almost equally as reducing power instead (PubMed:20572871).

559292:YOR035C
gene id: 559292:YOR035C
uniprot id: P51534
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 3410 molecules/cell in log phase SD medium.
messages: Required for mother cell-specific ho expression. Might be required for the transport of factors (such as ASH1) that promote HO repression from the mother cell into its bud.

559292:YBR286W
gene id: 559292:YBR286W
uniprot id: P37302
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28A subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Present with 4740 molecules/cell in log phase SD medium.
messages: Vacuole

559292:YML004C
gene id: 559292:YML004C
uniprot id: P50107
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:11050082, PubMed:8824231). Can use gamma-glutamylcysteine as a substrate (PubMed:8824231).
messages: Monomer.
messages: Present with 2570 molecules/cell in log phase SD medium.

559292:YMR135C
gene id: 559292:YMR135C
uniprot id: P40208
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GID8 family.
messages: Cytoplasm
messages: Identified in the GID complex. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is induced and becomes part of the complex (PubMed:22645139). Within the GID complex, interacts directly with VID30/GID1, RMD5/GID2 and FYV10/GID9 (PubMed:22645139).
messages: Nucleus
messages: Present with 639 molecules/cell in log phase SD medium.
messages: Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616). Required also for cell cycle progression. Positively controls G1 and the timing of START (PubMed:15590836).

559292:YJR021C
gene id: 559292:YJR021C
uniprot id: P21651
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Essential for meiotic chromosome segregation. MER1 and MER2 proteins must interact directly or indirectly. MER1 might be responsible for regulating the MER2 gene and/or gene product. MER2 is not required for mitosis and mitotic DNA repair mechanisms. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.
messages: Interacts with MEI4, REC114 and XRS2. Component of the MER2-MEI4-REC114 complex.
messages: Nucleus
messages: Phosphorylated during meiotic prophase. Dephosphorylation seems to be dependent on DSB formation.

559292:YDR495C
gene id: 559292:YDR495C
uniprot id: P23643
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS3 family.
messages: Cytoplasm
messages: Present with 2270 molecules/cell in log phase SD medium.
messages: Required for sorting and processing of soluble vacuolar proteins, integrity of vacuolar morphology, efficient segregation of vacuolar material into the bud during the cell cycle, acidification of the vacuolar lumen, and assembly of the vacuolar H(+)-ATPase.

559292:YGR056W
gene id: 559292:YGR056W
uniprot id: P53236
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RSC1 family.
messages: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in meiotic sporulation through regulating IME2 expression.
messages: Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YLR203C
gene id: 559292:YLR203C
uniprot id: P32335
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although no clear MSS51 ortholog is encoded in mammalian genomes, the mammalian MSS51/ZMYND17 protein of unknown function is significantly similar.
messages: Belongs to the MSS51 family.
messages: Has a dual role in the assembly of cytochrome oxidase subunit 1 (COX1). It has a regulative function on COX1 synthesis, acting as a translational activator specific for the COX1 mRNA, and it also binds to newly synthesized COX1 protein. Together with COX14, may act as a chaperone that binds efficiently unassembled COX1 and prevents it from unproductive aggregation. When bound to COX1, MSS51 is unable to interact with the COX1 mRNA and translation is halted. This may be a feedback control that ensures that COX1 is only produced as long as potentially harmful assembly intermediates are not accumulating.
messages: Interacts with COX1 and COX14.
messages: Mitochondrion inner membrane
messages: Present with 4800 molecules/cell in log phase SD medium.

559292:YLR257W
gene id: 559292:YLR257W
uniprot id: Q06146
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 18600 molecules/cell in log phase SD medium.

559292:YMR111C
gene id: 559292:YMR111C
uniprot id: Q04461
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Homodimer (PubMed:31015336). Interacts with SLX5 (PubMed:31015336).
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Prevents ub-hotspot formation and exacerbates heat sensitivity of cells deficient in Rpd3L histone deacetylase complex members (PubMed:31015336). Leads to the up-regulation of the expression of the Rpd3S complex subunit RCO1 of the Rpd3S complex and down-regulation of HSP12 and SIR2 (PubMed:31015336).
messages: Sumoylated at Lys-231 and subsequently ubiquitinated by the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8.
messages: The coiled-coil motif is required for homodimerization.
messages: Transcription factor-like protein that binds to specific DNA motifs called ub-HS-motif associated with several locations where proteins other than histone H2B are ubiquitinated (ub-hotspots) (PubMed:31015336). Ubiquitination at these sites depends on the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 and protein turnover on the CDC48 segregase (PubMed:31015336). UBC9, SIZ1, or SIZ2 sumoylate DNA-bound EUC1 to stabilize its DNA-binding (PubMed:31015336). Sumoylated EUC1 acts a cofactor required for the recruitment of the SLX5/SLX8 STUbL complex via specific contacts between EUC1 and SLX5, as well as an additional SUMO-mediated interaction (PubMed:31015336). SLX5/SLX8 then ubiquitinates EUC1 and presumably other targets at ub-hotspots, and the CDC48/UFD1/NPL4 complex, together with UBX4 and UBX5, removes Lys-48-linked ubiquitinated proteins from chromatin. Ubiquitinated proteins could be either degraded by the proteasome or recycled by deubiquitination (PubMed:31015336). EUC1 itself does not seem to underlie extensive turnover, as it is a very stable protein (PubMed:31015336). EUC1 is able to act as a transcription factor, but its function at ub-hotspots does not seem to depend on this ability (PubMed:31015336). EUC1-mediated ub-hotspots are crucial during stress responses when gene expression control is impaired (PubMed:31015336).

559292:YPR176C
gene id: 559292:YPR176C
uniprot id: P20133
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4.
messages: Heterodimer of an alpha and a beta subunit.
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:YCR047C
gene id: 559292:YCR047C
uniprot id: P25627
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Interacts with TRM112. Interacts with ECM16.
messages: Nucleus
messages: Present with 1620 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of guanine 1575 (m7G1575) in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Required for efficient cleavage of the primary 35S precursor rRNA at site A2. Involved in positioning the proximal bud pole signal.

559292:YOR346W
gene id: 559292:YOR346W
uniprot id: P12689
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.
messages: Interacts with REV7.
messages: Mitochondrion
messages: Nucleus
messages: Present with 521 molecules/cell in log phase SD medium.

559292:YAL055W
gene id: 559292:YAL055W
uniprot id: P39718
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-22 family.
messages: Involved in peroxisome biogenesis.
messages: Peroxisome membrane
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YLR175W
gene id: 559292:YLR175W
uniprot id: P33322
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pseudouridine synthase TruB family.
messages: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909, PubMed:25219674). Catalyzes pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs (PubMed:25219674). It is a centromeric DNA-CBF3-binding factor which is involved in mitotic chromosome segregation (PubMed:8336724). Essential for cell growth (PubMed:8336724).
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) (PubMed:9472021, PubMed:9848653, PubMed:15388873, PubMed:21131909). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10 (PubMed:9472021, PubMed:9848653, PubMed:15388873). The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind (PubMed:9472021, PubMed:9848653, PubMed:15388873). Also interacts with NAF1 and SHQ1, which may be required for assembly of H/ACA snoRNP complexes. May also associate with the CBF3 110 kDa subunit (CBF2). Interacts with the trimethylguanosine synthase (TGS1) and with NOP53.
messages: Present with 33600 molecules/cell in log phase SD medium.
messages: centromere
messages: cytoskeleton
messages: nucleolus

559292:YGR205W
gene id: 559292:YGR205W
uniprot id: P42938
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent kinase whose specificity is not yet known.
messages: Belongs to the GLYK kinase family.
messages: Cytoplasm
messages: Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.
messages: Nucleus
messages: Present with 4280 molecules/cell in log phase SD medium.

559292:YKL175W
gene id: 559292:YKL175W
uniprot id: P34240
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Transports zinc from storage in the vacuole to the cytoplasm.
messages: Vacuole membrane

559292:YPL177C
gene id: 559292:YPL177C
uniprot id: P41817
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/CUP9 homeobox family.
messages: Nucleus
messages: Present with 521 molecules/cell in log phase SD medium.
messages: Probable DNA-binding protein which plays a role in protecting yeast cells against copper toxicity. May regulate the expression of important copper homeostatic genes.

559292:YBR101C
gene id: 559292:YBR101C
uniprot id: P38260
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FES1 family.
messages: Cytoplasm
messages: Interacts with the Hsp70 chaperones SSA1 and SSB1.
messages: Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance. Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1. Required for fully efficient Hsp70-mediated folding of proteins.
messages: Present with 13100 molecules/cell in log phase SD medium.

559292:YDR423C
gene id: 559292:YDR423C
uniprot id: P24813
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. YAP subfamily.
messages: CAD1/YAP2 expression is at least partially regulated at the level of mRNA stability. Two small upstream open reading frames (uORF) in its mRNA cause increased RNA decay. The translation initiation factor eIF2 counteracts this effect by causing reinitiation at the functional initiation site, thus suppressing RNA decay.
messages: Contains a C-terminal cysteine rich domain (c-CRD), but lacks the N-terminal CRD (n-CRD) found in its paralog YAP1. It probably also contains embedded in the c-CRD a nuclear export signal, with which the nuclear export protein CRM1/exportin 1 may interact in the absence of inter- or intramolecular disulfide bonds (or otherwise oxidized/modified cysteines) within the c-CRD.
messages: Cytoplasm
messages: Depending on the oxidative stress inducing agent, CAD1/YAP2 can undergo two distinct conformational changes, both through oxidation of cysteine residues, and both masking the nuclear export signal, thus abolishing nuclear export by CRM1/exportin 1. Peroxide stress induces the formation of possible intramolecular disulfide bonds as well as intermolcular disulfide within a homodimer. Cadmium may bind directly to specific cysteine residues (Cys-391 and either Cys-356 or Cys-387) in the c-CRD.
messages: Homodimer; disulfide-linked, upon oxidation (Probable). Interacts in the nucleus with the nuclear export protein CRM1 (PubMed:17187783). Interacts with RCK1 (PubMed:15341652).
messages: Hypersensitive to the cytotoxic metal cadmium.
messages: Nucleus
messages: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
messages: Present with 623 molecules/cell in log phase SD medium.
messages: Transcription activator involved in oxidative stress response and cadmium resistance. Regulates the transcription of genes overrepresented for the function of stabilizing proteins including the inducible Hsp90-family protein HSP82. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Activation by alkyl hydroperoxides or cadmium induces nuclear accumulation and as a result CAD1/YAP2 transcriptional activity.

559292:YKL088W
gene id: 559292:YKL088W
uniprot id: P36076
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.
messages: Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex, a heterotrimer composed of CAB3, HAL3 and VHS3.
messages: Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis.
messages: Cytoplasm
messages: Present with 2940 molecules/cell in log phase SD medium.

559292:YMR181C
gene id: 559292:YMR181C
uniprot id: Q03231
names: Miscellaneous
names: Similarity
messages: Present with 721 molecules/cell in log phase SD medium.
messages: To yeast YPL229w.

559292:YOR350C
gene id: 559292:YOR350C
uniprot id: P24720
names: Miscellaneous
messages: Present with 861 molecules/cell in log phase SD medium.

559292:YPL084W
gene id: 559292:YPL084W
uniprot id: P48582
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. Acts as an adapter that recruits the DOA4 deubiquitinase to the endosomes, leading to deubiquitination of cargo proteins prior to the lumenal sequestration. Its association to the endosomes depends on SNF7 and its dissociation requires VPS4. Interacts functionally with the Pkc1p-mitogen-activated protein kinase pathway.
messages: Cytoplasm
messages: Endosome
messages: Interacts with DOA4 and SNF7.
messages: Present with 10200 molecules/cell in log phase SD medium.
messages: The BRO1 domain may be involved in the binding to SNF7.
messages: The coiled-coil domain is essential for MVB sorting.

559292:YDR294C
gene id: 559292:YDR294C
uniprot id: Q05567
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
messages: Endoplasmic reticulum membrane
messages: Glycosylated.
messages: Homodimer.
messages: Leads to the accumulation of endogenous phosphorylated sphingoid bases, and exhibits unregulated proliferation upon approach to stationary phase (PubMed:10329480). Causes a reduction in total C15 and C17 phosphatidylcholine levels (PubMed:25345524).
messages: Present with 13100 molecules/cell in log phase SD medium.
messages: Sphingosine-1-phosphate lyase that cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:20696404, PubMed:25345524, PubMed:9334171). Prefers C-16 dihydrosphingosine-l-phosphate (DHS-P) as a substrate. Regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs) (PubMed:11795842). Plays a role in the regulation of global responses to nutrient deprivation in yeast (PubMed:10329480).

559292:YCR024C
gene id: 559292:YCR024C
uniprot id: P25345
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of asparagine to tRNA(Asn) in the mitochondrion.
messages: Mitochondrion matrix
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YFR020W
gene id: 559292:YFR020W
uniprot id: P43600
names: PTM
names: Subcellular Location Annotation
messages: N-glycosylated.
messages: Secreted

559292:YFL049W
gene id: 559292:YFL049W
uniprot id: P43554
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RSC7/SWP82 family. SWP82 subfamily.
messages: Interacts with SWI3 and SNF12. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Nucleus
messages: Present with 3180 molecules/cell in log phase SD medium.

559292:YHL010C
gene id: 559292:YHL010C
uniprot id: P38748
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May act as a cytoplasmic retention protein with a role in regulating nuclear transport. Binds nuclear localization sequences in vitro. Needed to adapt efficiently to ethanol, either as sole carbon source or as cell stressor. Involved in ethanol-dependent transcriptional activation of several genes and ethanol-induced protein turnover of some proteins.

559292:YPL189C-A
gene id: 559292:YPL189C-A
uniprot id: Q3E823
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA2 family.
messages: Mitochondrion inner membrane
messages: Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Seems to be involved in the SHY1-mediated step of cytochrome c oxidase maturation. May aid in stabilizing an early COX1 intermediate containing the nuclear subunits COX5A and COX6.

559292:YML062C
gene id: 559292:YML062C
uniprot id: P33441
names: Caution
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the THO complex, which is composed of HPR1, MFT1, THO2 and THP2. Together with SUB2, TEX1 and YRA1, THO forms the transcription/export (TREX) complex. THO associates with DNA and RNA in vitro.
messages: Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
messages: Nucleus
messages: Present with 5910 molecules/cell in log phase SD medium.
messages: Was originally thought to be involved in mitochondrial protein import.

559292:YNL286W
gene id: 559292:YNL286W
uniprot id: P53830
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HTATSF1 family.
messages: Interacts with PRP11. Associates with the U2 snRNA.
messages: Present with 1360 molecules/cell in log phase SD medium.
messages: U2 snRNP protein which helps to refold U2 into a structure favorable for its binding to SF3b and SF3a prior to spliceosome assembly. Mediates functional interactions between U2 RNA and PRP5. Enforces ATP dependence during formation of the prespliceosome by brokering an interaction between PRP5 and the U2 snRNP that depends on correct U2 RNA structure.

559292:YDL072C
gene id: 559292:YDL072C
uniprot id: Q07451
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in invertase secretion.
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YAL002W
gene id: 559292:YAL002W
uniprot id: P39702
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS8 family.
messages: Golgi stack
messages: Present with 736 molecules/cell in log phase SD medium.
messages: Required for localization and recycling of the CPY sorting receptor (VPS10) to the late-Golgi compartment. Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process.

559292:YGR163W
gene id: 559292:YGR163W
uniprot id: P53290
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal punctate localization of TOR1 (PubMed:32801125). Sensitive to high hydrostatic pressure (PubMed:32801125). Resistance to tunicamycin (endoplasmic reticulum stressor) administered together with FK506 (calcineurin inhibitor) (PubMed:26510498). Sensitive to rapamycin (TORC1 signaling-inhibitor) (PubMed:28993463). Simultaneous disruption of GTR1 results in abnormal localization of TOR1 and PIB2 to vacuoles and abnormal activation of TORC1 in nitrogen-replete conditions (glutamine or leucine nitrogen source) (PubMed:28993463).
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions (PubMed:26510498, PubMed:15989961, PubMed:32801125, PubMed:28993463). Also required for TORC1 inactivation during nitrogen starvation (PubMed:28993463). Required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272). Involved in the regulation of microautophagy (PubMed:15989961).
messages: Heterodimer; with GTR1 (PubMed:21816923). Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1 (PubMed:16732272). Component of the EGO complex, at least composed of GTR2, SLM4 and MEH1 (PubMed:15989961). Interacts with GTR1; the interaction is direct (PubMed:21816923).
messages: Present with 2610 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YPL218W
gene id: 559292:YPL218W
uniprot id: P20606
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Interacts with EMP24.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP by SEC12 binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits.

559292:YBR040W
gene id: 559292:YBR040W
uniprot id: P38224
names: Function
names: Induction
names: Subcellular Location Annotation
messages: By mating pheromones.
messages: Membrane
messages: Required for efficient mating.

559292:YMR109W
gene id: 559292:YMR109W
uniprot id: Q04439
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Interacts (via myosin motor domain) with SHE4; this interaction is important for proper localization and may regulate the interaction of the motor domain with actin. Interacts (via SH3 domain) with VRP1; this interaction is required for localization to sites of polarized growth and may regulate the interaction of the tail domain with actin. Interacts (via SH3 domain) with PAN1; this interaction is important for late stages of endocytopsis. Interacts (via SH3 domain) with BBC1 and LAS17. Interacts (via C-terminal acidic tail) with ARC19 and ARC40; ARC19 and ARC40 are Arp2/3 complex subunits. Interacts with BZZ1, PKH1, PKH2, YPK1 and YPK2.
messages: One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.
messages: Phosphorylation of the TEDS site (Ser-357) is required for the polarization of the actin cytoskeleton and for ligand-induced, but not for constitutive internalization of STE2. Phosphorylation probably activates the myosin-I ATPase activity. Ser-357 is phosphorylated by YPK2 in vitro.
messages: Present with 2280 molecules/cell in log phase SD medium.
messages: The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.
messages: The tail domain participates in molecular interactions that specify the role of the motor domain. It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).
messages: actin patch

559292:YGR241C
gene id: 559292:YGR241C
uniprot id: P53309
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP180 family.
messages: Bud
messages: Bud neck
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with PAN1 and the clathrin heavy and light chains CHC1 and CLC1.
messages: Involved in endocytosis and clathrin cage assembly.
messages: Present with 6800 molecules/cell in log phase SD medium.

559292:YJL016W
gene id: 559292:YJL016W
uniprot id: P47072
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 3360 molecules/cell in log phase SD medium.

559292:YJL023C
gene id: 559292:YJL023C
uniprot id: P47065
names: Disruption Phenotype
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion matrix
messages: Mutants are deficient in mitochondrial protein synthesis.
messages: Present with 721 molecules/cell in log phase SD medium.

559292:YMR268C
gene id: 559292:YMR268C
uniprot id: P49960
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Binds preferentially to the U4/U6 hybrid snRNAs. Can stimulate the annealing of U4 and U6. Could participate in both the formation and disassembly of the U4/U6 hybrid during splicing.
messages: Nucleus
messages: Present with 672 molecules/cell in log phase SD medium.

559292:YHR133C
gene id: 559292:YHR133C
uniprot id: P38837
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Present with 1900 molecules/cell in log phase SD medium.
messages: Stabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation. Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation.

559292:YHR015W
gene id: 559292:YHR015W
uniprot id: P38760
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with MEX67.
messages: Present with 98 molecules/cell in log phase SD medium.

559292:YDL125C
gene id: 559292:YDL125C
uniprot id: Q04344
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HINT family.
messages: Expression is increased in response to DNA replication stress (PubMed:22842922). Expression is regulated by ZAP1 during zinc-deficiency via changes in transcription start sites (PubMed:31692084). Expression is also down-regulated during unfolded protein response (UPR) (PubMed:32475637, PubMed:33184379).
messages: Homodimer (By similarity). Interacts with KIN28 (PubMed:10958787).
messages: Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (PubMed:11805111). Plays a role in the regulation of kinase KIN28 function (PubMed:10958787). Essential for growth on galactose media at elevated temperatures (PubMed:11805111).
messages: It is uncertain whether Met-1 or Met-15 is the initiator.
messages: Present with 5410 molecules/cell in log phase SD medium.

559292:YOL145C
gene id: 559292:YOL145C
uniprot id: P89105
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PAF1 complex which consists of at least CDC73, CTR9, LEO1, PAF1 and RTF1. Interacts with SPT6. Interacts with FACT subunits POB3 and SPT16.
messages: Present with 12900 molecules/cell in log phase SD medium.
messages: The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. In complex with PAF1, required for normal CLN1 and CLN2 G1 cyclin expression in late G1. Also has a role in chromosome segregation where it appears to be involved in microtubule placement.
messages: nucleoplasm

559292:YPL081W
gene id: 559292:YPL081W
uniprot id: O13516
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS4 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). Interacts with snoRNA U3. uS11 interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).
messages: Cytoplasm
messages: Present with 106000 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS4 in yeast.
messages: nucleolus

559292:YGR120C
gene id: 559292:YGR120C
uniprot id: P53271
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG2 is required for ER to Golgi vesicle docking. Not essential for viability.
messages: Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. The COG complex interacts with the Rab GTPase YPT1, the Glogi SNAREs GOS1, SEC22, SED5, VTI1 and YKT6 and the COPI coatomer subunit gamma SEC21.
messages: Golgi apparatus membrane
messages: Present with 3270 molecules/cell in log phase SD medium.

559292:YEL063C
gene id: 559292:YEL063C
uniprot id: P04817
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes canavanine sensitivity (PubMed:3327612). Extends replicative lifespan and leads to distinct changes in transcriptional and translational profiles, including translational activation of the GCN4 transcription factor (PubMed:28228255).
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Endosome membrane
messages: High-affinity permease for arginine (PubMed:8436127, PubMed:9231419, PubMed:10654085, PubMed:11746604).
messages: Interacts with RRT2 (PubMed:21880895).
messages: Phosphorylated probably at multiple sites (PubMed:9544242).

559292:YJR103W
gene id: 559292:YJR103W
uniprot id: P38627
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by GTP. Subject to allosteric product inhibition by CTP. Inhibited by p-chloromercuriphenylsulfonic acid, N-ethylmaleimide and cyclopentenylcytosine (CPEC).
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis.
messages: Cytoplasm
messages: Homodimer. Oligomerizes to a tetramer in the presence of its substrates UTP and ATP.
messages: Present with 5370 molecules/cell in log phase SD medium.

559292:YBR230C
gene id: 559292:YBR230C
uniprot id: P38325
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane
messages: Present with 4750 molecules/cell in log phase SD medium.

559292:YNL236W
gene id: 559292:YNL236W
uniprot id: P32259
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Interacts with HOG1.
messages: Nucleus
messages: Phosphorylated by KIN28.
messages: Present with 1720 molecules/cell in log phase SD medium.

559292:YOL012C
gene id: 559292:YOL012C
uniprot id: Q12692
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1, a component of the NuA4 histone acetyltransferase (HAT) complex, and/or by GCN5, a component of the SAGA complex, to form H2A.ZK3Ac, H2A.ZK8Ac, H2A.ZK10Ac and H2A.ZK14Ac once deposited into chromatin (PubMed:16543223). Acetylation is required for function at telomeres (PubMed:16543222). H2A.ZK14Ac is acetylated at the promoters of active genes (PubMed:16543223).
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: In contrast to H2A1 and H2A2, appears to be weakly or not sumoylated.
messages: Nucleus
messages: Present with 2840 molecules/cell in log phase SD medium.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers (Probable). The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Interacts also with RBP1/DNA-directed RNA polymerase II largest subunit (PubMed:11509669). Interacts with NAP1 (PubMed:14645854, PubMed:14690608, PubMed:15045029, PubMed:16299513, PubMed:18086883). Interacts with MPS3 (PubMed:21518795).
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2A.ZK3ac = acetylated Lys-4; H2A.ZK8ac = acetylated Lys-9; H2A.ZK10ac = acetylated Lys-11; H2A.ZK14ac = acetylated Lys-15.
messages: Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received (PubMed:11000274, PubMed:11081628, PubMed:11090616, PubMed:11509669, PubMed:12628191, PubMed:14645854, PubMed:14690608, PubMed:15045029, PubMed:16239142, PubMed:16344463, PubMed:16543223). Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins (PubMed:16543222). Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes (PubMed:11509669). Involved in chromosome stability (PubMed:15353583). Required to target MPS3 to the inner membrane of the nuclear envelope (PubMed:21518795).

559292:YKL193C
gene id: 559292:YKL193C
uniprot id: P36047
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDS22 family.
messages: Interacts with YPI1.
messages: Nucleus
messages: Present with 3870 molecules/cell in log phase SD medium.
messages: Regulator of the mitotic function of yeast type 1 protein phosphatase.

559292:YMR140W
gene id: 559292:YMR140W
uniprot id: P40210
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIP5 family.
messages: Cytoplasm
messages: Interacts with NPA1, SNF1 and REG1.
messages: May negatively regulate the SNF1 kinase by promoting the interaction of the REG1/GLC7 phosphatase complex with the kinase. Deletion of SIP5 promotes resistance to artimisin, which is probably an indirect effect of an action on the electron transport chain.
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YDR192C
gene id: 559292:YDR192C
uniprot id: P49686
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC) (PubMed:10684247). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP42 interacts with the NUP82 subcomplex. It interacts directly with GLE1, and through its FG repeats with GFD1, the heterodimeric mRNA transport factor MEX67/MTR2, and the karyopherin CRM1.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: SXFG/PXFG repeats are especially abundant in NUPs on the cytoplasmic side.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP42 is specifically important for nuclear protein and mRNA export.
messages: Nucleus membrane
messages: nuclear pore complex

559292:YMR263W
gene id: 559292:YMR263W
uniprot id: P38429
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAP30 family.
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
messages: Nucleus
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YNL270C
gene id: 559292:YNL270C
uniprot id: P38971
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: High-affinity permease for basic amino acids.
messages: Membrane

559292:YIL090W
gene id: 559292:YIL090W
uniprot id: P40499
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 606 molecules/cell in log phase SD medium.

559292:YOL082W
gene id: 559292:YOL082W
uniprot id: P35193
names: Biotechnology
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ATG19 is important for yeast autolysis which is the source of several molecules responsible for the quality of wines aged in contact with yeast cells.
messages: Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Also plays a role in regulation of filamentous growth.
messages: Interacts with the vacuolar aminopeptidase 1 (LAP4) precursor and mature forms. Also interacts with AMS1, APE4, ATG8 ATG11, and UBP3.
messages: Polyubiquitinated at Lys-213 and Lys-216. Deubiquitination by UBP3 is required for full activity of ATG19.
messages: Preautophagosomal structure membrane
messages: Present with 1250 molecules/cell in log phase SD medium.
messages: The C-terminal WXXL motif is crucial for ATG8-binding and Cvt pathway.
messages: The coiled coil domain is required for the interaction with LAP4.

559292:YBL107C
gene id: 559292:YBL107C
uniprot id: P38162
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIX23 family.
messages: Mitochondrion intermembrane space
messages: Present with 768 molecules/cell in log phase SD medium.
messages: Regulator of the mitochondrial protein import machinery that is localized in the mitochondrial intermembrane space (IMS) and facilitates the transport of proteins from the cytosol into the mitochondrial matrix (PubMed:32826315). Not essential for mitochondrial protein import but induced and required when mitochondrial import is compromised (PubMed:32826315). Stimulates or stabilizes the translocation into the mitochondria of proteins such as OXA1, ATP1 and COX12 (PubMed:32826315).
messages: The Cx14C/Cx13C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.
messages: Up-regulated by RPN4 transcription factor upon mitochondrial protein-induced stress conditions such as the accumulation in the cytosol of non-imported mitochondrial precursors.

559292:YAL007C
gene id: 559292:YAL007C
uniprot id: P39704
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with EMP24, ERV25 and ERP1.
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Involved in vesicular protein trafficking.
messages: Present with 26300 molecules/cell in log phase SD medium.

559292:YBL100W-A
gene id: 559292:YBL100W-A
uniprot id: Q12260
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YNR024W
gene id: 559292:YNR024W
uniprot id: P53725
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA) derived from intergenic regions and the ribosomal DNA spacer heterochromatin. Binds RNA.
messages: Lethal in combination with the absence of either RRP6 or its cofactor RRP47. Weak but detectable stabilization of unspliced pre-mRNAs, and stronger stabilization is detected for mRNAs with defects in 3' cleavage and polyadenylation.
messages: Nucleus
messages: Present with 1350 molecules/cell in log phase SD medium.

559292:YGL113W
gene id: 559292:YGL113W
uniprot id: P53135
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CDC45 and SLD7.
messages: Nucleus
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins.

559292:YPL086C
gene id: 559292:YPL086C
uniprot id: Q02908
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster (PubMed:16420352). The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (PubMed:16420352). The cluster is required for structural integrity of the elongator complex, while it is not required for catalytic activity (PubMed:18986986).
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:17018299, PubMed:18755837, PubMed:21912530, PubMed:31309145). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). The complex functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368). Independently, ELP3 may be involved in polarized exocytosis (PubMed:15780940).
messages: Component of the elongator complex which consists of ELP1/IKI3, ELP2, ELP3, ELP4, ELP5/IKI1 and ELP6 (PubMed:10445034, PubMed:11435442, PubMed:11689709, PubMed:18986986, PubMed:27974378, PubMed:27872205). The elongator complex is composed of two copies of the Elp123 subcomplex (composed of ELP1/IKI3, ELP2 and ELP3) and two copies of the Elp456 subcomplex (composed of ELP4, ELP5/IKI1 and ELP6) (PubMed:27974378, PubMed:27872205). The Elp123 subcomplex forms a two-lobed scaffold, which binds the Elp456 subcomplex asymmetrically (PubMed:27974378, PubMed:27872205, PubMed:25960406). In each lobe, ELP2 is tightly sandwiched between ELP1/IKI3 and ELP3 (PubMed:31309145). The Elp123 subcomplex binds tRNA through ELP1/IKI3 and ELP3 and can bind 2 tRNAs simultaneously (PubMed:31309145). tRNA-binding induces conformational rearrangements which precisely position the targeted anticodon base in the active site (PubMed:31309145). ELP3 interacts with KTI11/DPH3 (PubMed:18986986, PubMed:27694803). ELP3 interacts with KTI12 (PubMed:15772087). The Elp456 subcomplex binds tRNA and has ATPase activity (PubMed:22343726).
messages: Cytoplasm
messages: Nucleus
messages: Present with 4760 molecules/cell in log phase SD medium.
messages: Sensitive to caffeine and thermal stress (PubMed:18627462). Resistance to zymocin (PubMed:27694803, PubMed:18627462).
messages: The elongator complex was originally thought to play a role in transcription elongation. Was reported to display histone acetyltransferase activity and to acetylate histone H3 preferentially at 'Lys-14', and H4 preferentially at 'Lys-8' (PubMed:10445034, PubMed:11904415, PubMed:15138274). However, it was later shown that the effect on histone acetylation and chromatin regulation is indirect and that the elongator complex is primarily involved in tRNA modification (PubMed:17018299, PubMed:18986986, PubMed:21912530).

559292:YER059W
gene id: 559292:YER059W
uniprot id: P40038
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. PHO80 subfamily.
messages: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL7, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. The PCL6-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase. PCL6-PHO85 also phosphorylates YJL084C.
messages: Cytoplasm
messages: Forms a cyclin-CDK complex with PHO85. Interacts with the substrate protein YJL084C. Interacts with elongin-C, which stabilizes PCL6. Interacts with the CDK inhibitor (CKI) PHO81.
messages: Nucleus
messages: Present with 1240 molecules/cell in log phase SD medium.

559292:YPL068C
gene id: 559292:YPL068C
uniprot id: Q02749
names: Subcellular Location Annotation
messages: Nucleus

559292:YHR169W
gene id: 559292:YHR169W
uniprot id: P38719
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth.
messages: Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
messages: Interacts with ESF2.
messages: Present with 3500 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YGL112C
gene id: 559292:YGL112C
uniprot id: P53040
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF6 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the regulatory transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
messages: In TFIID, TAF6 heterodimerizes with TAF9, forming ultimately an octamer consisting of a TAF6/TAF9 heterotetramer core flanked by TAF4/TAF12 dimers on either side, similar to the histone H2A/H2B/H3/H4 octamer. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. Component of the 1.8 MDa SAGA complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9.
messages: Nucleus
messages: Present with 6506 (+/-1290) molecules/cell in log phase SD medium.

559292:YDR011W
gene id: 559292:YDR011W
uniprot id: P32568
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Could be an ATP-dependent permease. Confers hyper-resistance to the mutagens 4-nitroquinoline-N-oxide (4-NQO) and triaziquone, as well as to the chemicals sulphomethuron methyl phenanthroline when present in multiple copies. Exhibits nucleoside triphosphatase activity.
messages: Membrane
messages: Present with 1300 molecules/cell in log phase SD medium.

559292:YFL011W
gene id: 559292:YFL011W
uniprot id: P43581
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Probable glucose transporter.

559292:YCL058W-A
gene id: 559292:YCL058W-A
uniprot id: Q2V2Q1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADF1 family.
messages: Encoded by the antisense strand of the FYV5 gene.
messages: Nucleus
messages: Transcriptional repressor which negatively regulates transcription of FYV5 by binding to the promoter on the sense strand.

559292:YNL009W
gene id: 559292:YNL009W
uniprot id: P53982
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: May function in the production of NADPH for fatty acid and sterol synthesis.

559292:YAL039C
gene id: 559292:YAL039C
uniprot id: P06182
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Present with 3870 molecules/cell in log phase SD medium.

559292:YNL221C
gene id: 559292:YNL221C
uniprot id: P41812
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Cytoplasm
messages: Nucleus
messages: Present with 846 molecules/cell in log phase SD medium.
messages: Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA.

559292:YOL159C
gene id: 559292:YOL159C
uniprot id: Q08300
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Leads to elevated levels of Ty1 retrotransposition and Ty1 cDNA.
messages: Secreted

559292:YER183C
gene id: 559292:YER183C
uniprot id: P40099
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Abolishes methenyltetrahydrofolate synthase activity and leads to accumulation of folinic acid. Leads to a striking methionine deficiency when combined with ADE16 and ADE17, 2 isoenzymes involved in the purine synthesis.
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
messages: Mitochondrion
messages: N-glycosylated.
messages: Only enzyme known to utilize 5-formyltetrahydrofolate (folinic acid) as substrate. Contributes to tetrahydrofolate metabolism in an alternative way of folate biosynthesis. May regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YDR190C
gene id: 559292:YDR190C
uniprot id: Q03940
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes. Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates. The INO80 complex is involved in DNA repair by associating to 'Ser-129' phosphorylated H2A histones as a response to DNA damage. RVB1 recruits ARP5 to the INO80 complex. During transcription may recruit SPT15/TBP to the TATA-boxes of involved genes. Required for box C/D and box H/ACA snoRNA accumulation and involved in pre-rRNA processing.
messages: Nucleus
messages: Present with 11600 molecules/cell in log phase SD medium.
messages: Probably forms a homohexamer. Interacts with RVB2 and may form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1. Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Component of the R2TP complex composed of at least RVB1, RVB2, TAH1 and PIH1. Interacts with SPT15/TBP and HSP90.

559292:YMR319C
gene id: 559292:YMR319C
uniprot id: P40988
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FET4 family.
messages: By iron deprivation.
messages: Membrane
messages: Present with 573 molecules/cell in log phase SD medium.
messages: Required for Fe(2+) ion low affinity uptake.

559292:YOL068C
gene id: 559292:YOL068C
uniprot id: P53685
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Identified in the Set3C complex with HOS2, SIF2, SNT1, CPR1, HOS4/YIL112W and SET3. Its presence is however not essential for meiotic repression by the Set3C complex. Interacts with SUM1 and RFM1. The interaction with SUM1 is mediated by RFM1.
messages: NAD-dependent histone deacetylase involved in telomeric silencing. Histone deacetylase proteins act via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Restores silencing at HMR in SIR2 mutants when overexpressed. Required to repress middle sporulation genes during vegetative growth. Acts as a sensor of NAD(+) levels and regulator of NAD(+) biosynthesis. Regulates the gene expression of de novo NAD(+) biosynthesis genes.
messages: Nucleus
messages: Present with 1440 molecules/cell in log phase SD medium.

559292:YCL008C
gene id: 559292:YCL008C
uniprot id: P25604
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of STP22, VPS28, SRN2 and MVB12 in a 1:1:1:1 stoichiometry. Interacts with HSE1 and VPS27. Interacts with MVB12 and SRN2.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.
messages: Cytoplasm
messages: Endosome
messages: Late endosome membrane
messages: Present with 1360 molecules/cell in log phase SD medium.
messages: The UEV domain is required for the interaction of the complex with ubiquitin.

559292:YPL200W
gene id: 559292:YPL200W
uniprot id: Q08955
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with MPS3.
messages: Involved in chromosome segregation during meiosis. Involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements.
messages: Nucleus membrane

559292:YBR105C
gene id: 559292:YBR105C
uniprot id: P38263
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GID4/VID24 family.
messages: Cytoplasmic vesicle membrane
messages: Present with 6650 molecules/cell in log phase SD medium.
messages: Rapidly induced by a shift to glucose-containing medium.
messages: Substrate-recognition component of the GID complex, a multisubunit ubiquitin ligase that targets enzymes involved in gluconeogenesis for proteasomal degradation when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:18508925, PubMed:28126757). Specific for substrates with an N-terminal Pro (Pro/N-degron), including FBP1, ICL1 and MDH2 (PubMed:28126757). Has high affinity for the N-terminal sequence Pro-Thr-Leu-Val, and can bind peptides with an N-terminal sequence of the type Pro-[Gly,Ala,Ser,Thr,Asp,Asn,Tyr,His]-[Ala,Val,Leu,Ile,Lys,Arg]-[Val,Cys,Pro,Leu,Ile,Trp] (PubMed:28126757). Required for vacuolar degradation of FBP1 when cells are shifted to glucose-containing medium, probably by targeting FBP1-containing vesicles to the vacuole, but is not required for FBP1 sequestration in cytoplasmic vesicles (PubMed:9508768).
messages: Substrate-recognition component of the GID ubiquitin ligase complex; interacts with proteins that have an N-terminal Pro/N-degron, including FBP1, ICL1 and MDH2 (PubMed:28126757). Identified in the GID complex, but only when cells are shifted to glucose-containing medium. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is recruited to the complex via interaction with VID28/GID5 (PubMed:22645139).
messages: To yeast YGR066c and S.pombe SpAC3H1.14.
messages: Ubiquitinated by the GID complex, leading to subsequent proteasomal degradation.

559292:YPR075C
gene id: 559292:YPR075C
uniprot id: Q06810
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of the high-osmolarity glycerol (HOG) pathway involved in mating response and osmotolerance. May act as a membrane anchor for the STE50/STE11 complex.
messages: Present with 1160 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YBR269C
gene id: 559292:YBR269C
uniprot id: P38345
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF4 family.
messages: Interacts with SDH1 in its FAD-bound form.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit SDH1 in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDH2 into the SDH catalytic dimer.

559292:YCL031C
gene id: 559292:YCL031C
uniprot id: P25368
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP7 family.
messages: Component of the 90S pre-ribosomal particle.
messages: Plays an important role in the synthesis of 18S rRNA but is not required for the 5.8S and 25S pathway. Is necessary for the cleavage at site A2. Is required for efficient association of RPS27 with the pre-ribosomal particle.
messages: Present with 2610 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YCL048W-A
gene id: 559292:YCL048W-A
uniprot id: Q2V2Q2
names: Subcellular Location Annotation
messages: Cell membrane

559292:YHR045W
gene id: 559292:YHR045W
uniprot id: P38775
names: Subcellular Location Annotation
messages: Membrane

559292:YCL039W
gene id: 559292:YCL039W
uniprot id: P25569
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in the GID complex. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is induced and becomes part of the complex (PubMed:22645139). Within the GID complex, interacts with VID30/GID1; the interaction is direct (PubMed:22645139).
messages: Nucleus
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616).

559292:YJR055W
gene id: 559292:YJR055W
uniprot id: P46973
names: Miscellaneous
messages: Present with 2730 molecules/cell in log phase SD medium.

559292:YFL045C
gene id: 559292:YFL045C
uniprot id: P07283
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions such as folding and glycosylation of secretory proteins in the ER lumen.
messages: Present with 3500 molecules/cell in log phase SD medium.

559292:YHL027W
gene id: 559292:YHL027W
uniprot id: P33400
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by C-terminal proteolytic cleavage. At neutral to alkaline ambient pH, the signaling protease (probably RIM13) cleaves RIM101, removing a C-terminal 8 kDa peptide to yield the active form.
messages: Belongs to the pacC/RIM101 family.
messages: Binds to DNA. Interacts with RIM20, which probably binds to the two YPX[LI] motifs and is required for proteolytic processing.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1822 molecules/cell in log phase SD medium.
messages: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes. Required for meiosis, sporulation and invasive growth.

559292:YLR401C
gene id: 559292:YLR401C
uniprot id: Q06053
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:12003496, PubMed:14970222). Specifically modifies U47 in cytoplasmic tRNAs (PubMed:14970222). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
messages: Cytoplasm
messages: Nucleus

559292:YLR287C-A
gene id: 559292:YLR287C-A
uniprot id: P0CX33
uniprot id: P0CX34
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS30 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 18500 molecules/cell in log phase SD medium.
messages: Present with 37600 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS30 in yeast.

559292:YNR020C
gene id: 559292:YNR020C
uniprot id: P53722
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M76 family.
messages: Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes the N-terminal 10 residues of mitochondrial ATPase CF(0) subunit 6 (ATP6) at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of ATP6 with the subunit 9 ring.
messages: Interacts with ATP6.
messages: Mitochondrion inner membrane

559292:YEL070W
gene id: 559292:YEL070W
uniprot id: P0CX08
uniprot id: P0CX09
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.
messages: Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Rescues temperature-sensitivity of MPT5 deletion.
messages: There are two genes for this mannitol dehydrogenase in yeast, DSF1 and YNR073C.

559292:YGL247W
gene id: 559292:YGL247W
uniprot id: P53062
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRL1/BRR6 family.
messages: Interacts with BRL1.
messages: Nucleus membrane
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Required for mRNA nuclear export. Involved in the nuclear pore complex (NPC) distribution and nuclear envelope morphology.

559292:YOR116C
gene id: 559292:YOR116C
uniprot id: P04051
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
messages: Nucleus
messages: Present with 6020 molecules/cell in log phase SD medium.

559292:YIL053W
gene id: 559292:YIL053W
uniprot id: P41277
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.
messages: Cytoplasm
messages: In response to both anaerobic and osmotic stress. Expression seems to be under the control of YIG1.
messages: Leads to osmosensitivity.
messages: Major isoform of glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis. Plays a role in osmoadaptation and required for adaptation to anaerobic conditions.
messages: Monomer.
messages: Nucleus
messages: Present with 193000 molecules/cell in log phase SD medium.

559292:YGL258W
gene id: 559292:YGL258W
uniprot id: P53058
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VEL1 family.
messages: In zinc-depleted conditions and has increased expression in NAP1 deletion mutants.
messages: N-glycosylated.
messages: cytosol

559292:YGL168W
gene id: 559292:YGL168W
uniprot id: P45820
names: Caution
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Deletion HUR1 has been reported to cause increased sensitivity to hydroxyurea (PubMed:12615994). However, HUR1 partially overlaps with PMR1 and a later analysis revealed that deletion of PMR1 but not HUR1 affected resistance to hydroxyurea (PubMed:18069899).
messages: Membrane
messages: No increased sensitivity to hydroxyurea.

559292:Q0060
gene id: 559292:Q0060
uniprot id: P03877
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: Membrane
messages: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with high specificity and cleaves the sequence 5'-GGTTTTGGTAACTATTTATTAC-3'.
messages: Mitochondrion
messages: Strain Capensis / YB4237 has two stop codons in position 276 and 407, which disrupt the gene coding for this protein. Consequently, the corresponding intron containing its coding sequence is not mobile.
messages: The mature protein may arise from proteolytic cleavage of an in-frame translation of some COX1 exons plus the intron containing the aI3 open reading frame.

559292:YBR166C
gene id: 559292:YBR166C
uniprot id: P20049
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.
messages: Presence of Phe represses the TYR1 gene expression.
messages: Present with 2180 molecules/cell in log phase SD medium.

559292:YMR120C
gene id: 559292:YMR120C
uniprot id: P38009
names: Domain
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PurH family.
messages: Homodimer (Possible).
messages: Present with 60900 molecules/cell in log phase SD medium.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

559292:YDL130W
gene id: 559292:YDL130W
uniprot id: P10622
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A (PubMed:16573688, PubMed:11431471).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 22400 molecules/cell in log phase SD medium.
messages: The 4 small acidic ribosomal P-proteins from yeast can be classified into two couples of similar but not identical sequences. Each couple (P1A/P1B and P2A/P2B) is distinctly related to one of the two acidic ribosomal P-proteins P1/P2 present in multicellular organisms.

559292:YKR052C
gene id: 559292:YKR052C
uniprot id: P23500
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: MRS4 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). Not essential.
messages: Mitochondrion inner membrane
messages: Present with 1340 molecules/cell in log phase SD medium.

559292:YNL166C
gene id: 559292:YNL166C
uniprot id: P53890
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Bud
messages: Component of the GIN4 complex composed of at least BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. Interacts directly with CDC11 and CDC12.
messages: Cytoplasm
messages: Expression peaks during S phase of the cell cycle.
messages: Required for normal septin function and cytokinesis.

559292:YGL156W
gene id: 559292:YGL156W
uniprot id: P22855
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.
messages: Composed of isoforms with three constituent polypeptides described as [(107 kDa)-n (73 kDa)-(6-n) (31 kDa)-(6-n)], where n is 0-6. The 73 kDa and the 31 kDa polypeptides may be proteolytic derivatives of the 107 kDa polypeptide in the vacuole. Oligomerizes in the cytoplasm and retains its oligomeric form during import into the vacuole.
messages: Degrades free oligosaccharides in the vacuole.
messages: It is not specific for the 1,2-alpha-mannosidic linkage.
messages: Present with 319 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.
messages: Vacuole

559292:YNL091W
gene id: 559292:YNL091W
uniprot id: P53935
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NST1 family.
messages: Cytoplasm
messages: Interacts with MSL1.
messages: Present with 217 molecules/cell in log phase SD medium.
messages: With MSL1, acts as a negative regulator of salt tolerance.

559292:YLR452C
gene id: 559292:YLR452C
uniprot id: P11972
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
messages: By exposure to pheromone.
messages: Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone.
messages: Phosphorylated by FUS3 and KSS1.
messages: Present with 5980 molecules/cell in log phase SD medium.
messages: The fungal-differentiation regulator (Fungal-DR) domain is only found in fungal regulator of G-protein signaling (RGS) proteins that regulate differentiation pathways. It is required for function (By similarity).

559292:YBL106C
gene id: 559292:YBL106C
uniprot id: P38163
names: Function
names: Similarity
names: Subunit
messages: Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth.
messages: Belongs to the WD repeat L(2)GL family.
messages: Interacts with SEC9.

559292:YKR024C
gene id: 559292:YKR024C
uniprot id: P36120
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
messages: Present with 1460 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YLR133W
gene id: 559292:YLR133W
uniprot id: P20485
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the choline/ethanolamine kinase family.
messages: Catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway (PubMed:2536698, PubMed:9506987, PubMed:10329685). Also exhibits ethanolamine kinase activity but it is a poor substrate at 14% efficiency compared with choline (PubMed:2536698, PubMed:9506987).
messages: Cytoplasm
messages: Monomer. Interacts with NAP1.
messages: Present with 3930 molecules/cell in log phase SD medium.

559292:YOL076W
gene id: 559292:YOL076W
uniprot id: Q12387
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM20/NAA25 family.
messages: Component of the N-terminal acetyltransferase B (NatB) complex, which is composed of NAT3 and MDM20.
messages: Cytoplasm
messages: Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions. MDM20 is required for mitochondrial inheritance during budding and together with TPM1, is essential for the integrity and assembly of actin cables. Genetically interacts with CIN8.
messages: Present with 5800 molecules/cell in log phase SD medium.

559292:YOR307C
gene id: 559292:YOR307C
uniprot id: P22215
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Able to suppress the functional loss of YPT1. May form a channel. Protein SLY41 is not essential for cell viability. The SLY41 gene is a multicopy suppressor.
messages: Belongs to the TPT transporter family.
messages: Membrane
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YPR148C
gene id: 559292:YPR148C
uniprot id: Q06523
names: Subcellular Location Annotation
messages: Cytoplasm

559292:YDR184C
gene id: 559292:YDR184C
uniprot id: Q04005
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cation homeostasis and in the regulation of the cation stress signaling cascades. Also involved in bipolar budding.
messages: Nucleus
messages: Present with 846 molecules/cell in log phase SD medium.

559292:YNL051W
gene id: 559292:YNL051W
uniprot id: P53951
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
messages: Belongs to the COG5 family.
messages: Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.
messages: Golgi apparatus membrane
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YLR017W
gene id: 559292:YLR017W
uniprot id: Q07938
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Seems to be implicated in the regulation of the expression of the ADH2 gene.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus
messages: Present with 4820 molecules/cell in log phase SD medium.

559292:YPL278C
gene id: 559292:YPL278C
uniprot id: Q08990
names: Caution
messages: Could be the product of a pseudogene. YPL277C and YPL278C correspond to the N- and C-terminal regions of the uncharacterized protein YOR389W, respectively.

559292:YOR070C
gene id: 559292:YOR070C
uniprot id: Q08484
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: GTPase-activating protein (GAP) that stimulates specifically the intrinsic GTPase activity of Ypt/Rab-type GTPases YPT1 and YPT7 (PubMed:11359917, PubMed:19386605). Functions on the Golgi as a negative regulator of YPT1 (PubMed:11359917). Functions on the vacuole as a negative regulator of YPT7 (PubMed:11118206, PubMed:19386605). It is also active on SEC4 and YPT51 (PubMed:10508155). Provides a catalytic arginine (arginine finger) and glutamine (glutamine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable) (PubMed:16855591).
messages: Golgi stack
messages: Present with 206 molecules/cell in log phase SD medium.

559292:YNL065W
gene id: 559292:YNL065W
uniprot id: P53943
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: Membrane
messages: Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine.

559292:YEL025C
gene id: 559292:YEL025C
uniprot id: P39991
names: Subcellular Location Annotation
messages: Membrane

559292:YHR075C
gene id: 559292:YHR075C
uniprot id: P38796
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunits PPH21 and PPH22. Forms inactive complexes (PP2Ai) with phosphatase PP2A-like catalytic subunits. Involved in the regulation of cell cycle progression at START.
messages: Interacts with and inactivates the phosphatase PP2A-like catalytic subunits PPG1, PPH21, PPH22, PPH3 and SIT4.
messages: Was originally thought to be a mitochondrial ribosomal protein (PubMed:9151978), but has not been identified in the structure of the yeast mitoribosome (PubMed:28154081).

559292:YJL174W
gene id: 559292:YJL174W
uniprot id: P39005
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: O-glycosylated.
messages: cell wall

559292:YJR001W
gene id: 559292:YJR001W
uniprot id: P47082
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Present with 1820 molecules/cell in log phase SD medium.
messages: Required for the vacuolar uptake of large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine. Requires ATP for function.
messages: Vacuole membrane

559292:YER065C
gene id: 559292:YER065C
uniprot id: P28240
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
messages: Cytoplasm
messages: Homotetramer.
messages: Impairs growth when acetate or ethanol are the sole carbon source. Leads to reduced chronological lifespan.
messages: Phosphorylated and inactivated after addition of glucose to the cell culture (repressing conditions).
messages: Phosphorylated in response to elevated glucose levels, leading first to reversible inactivation of the enzyme (short-term inactivation), and at a later stage to proteolytic degradation of the protein (long-term inactivation).
messages: Repressed by glucose and induced by ethanol via the transcriptional activator CAT8. The promoter sequence located between -397 and -388 contains an upstream activating sequence (UAS)element whereas the sequence located between -261 and -242 contains an upstream repressing sequence (URS) element.
messages: Vacuole
messages: Yeast isocitrate lyase is the only eukaryotic member of this family that is located in the cytoplasm, instead of being targeted to the peroxisome or the glyoxysome.
messages: extracellular matrix

559292:YPR120C
gene id: 559292:YPR120C
uniprot id: P30283
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Maximally expressed just before cell cycle start.
messages: Present with 521 molecules/cell in log phase SD medium.
messages: Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28.

559292:YBR019C
gene id: 559292:YBR019C
uniprot id: P04397
names: Function
names: Induction
names: Similarity
messages: By galactose.
messages: In the C-terminal section; belongs to the aldose epimerase family.
messages: In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).

559292:YER040W
gene id: 559292:YER040W
uniprot id: P18494
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Positive nitrogen regulatory protein. Required for the activation of transcription of a number of genes (including the allantoin pathway genes) in response to the replacement of glutamine by glutamate as source of nitrogen. Binds the nitrogen upstream activation sequence of GLN1, the gene encoding glutamine synthetase. URE2 may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.
messages: Present with 589 molecules/cell in log phase SD medium.
messages: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

559292:YBR236C
gene id: 559292:YBR236C
uniprot id: P32783
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: Nucleus
messages: Responsible for methylating the 5'-cap structure of mRNAs.

559292:YBR252W
gene id: 559292:YBR252W
uniprot id: P33317
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the dUTPase family.
messages: Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions.
messages: Homotrimer.
messages: Present with 4340 molecules/cell in log phase SD medium.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

559292:YDL185W
gene id: 559292:YDL185W
uniprot id: P17255
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:2139027, PubMed:18055462). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:2139027, PubMed:18055462).
messages: Endomembrane system
messages: PI-SceI is an endonuclease that can cleave at a site present in a VMA1 allele that lacks the derived endonuclease segment of the open reading frame; cleavage at this site only occurs during meiosis and initiates 'homing', a genetic event that converts a VMA1 allele lacking VDE into one that contains it.
messages: Present with 199895 molecules/cell in log phase SD medium.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:25971514, PubMed:18055462, PubMed:27295975). Interacts with RAV1 and RAV2 components of the RAVE complex, which are essential for the stability and assembly of V-ATPase (PubMed:11283612).
messages: Vacuole membrane

559292:YOR093C
gene id: 559292:YOR093C
uniprot id: Q12275
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 41 molecules/cell in log phase SD medium.

559292:YNL188W
gene id: 559292:YNL188W
uniprot id: P11927
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with SPC72.
messages: KAR1 is required for function of both intranuclear and extranuclear microtubules. KAR1 helps localize CDC31 to the spindle pole body (SPB), CDC31 then initiates SPB duplication via interaction with a downstream effector.
messages: spindle pole body

559292:YDR515W
gene id: 559292:YDR515W
uniprot id: Q12034
names: Function
names: Miscellaneous
messages: Present with 861 molecules/cell in log phase SD medium.
messages: Regulates the copper-dependent mineralization of copper sulfide complexes on the cell surface in cells cultured in medium containing copper salts.

559292:YOL004W
gene id: 559292:YOL004W
uniprot id: P22579
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SIN3 has also a RPD3 independent function required for normal longevity.
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Component of the RPD3C(S) complex composed of at least EAF3, RCO1, RPD3, SIN3, and UME1. Interacts with ESS1 and STB1.
messages: Nucleus
messages: Present with 1660 molecules/cell in log phase SD medium.

559292:YGL153W
gene id: 559292:YGL153W
uniprot id: P53112
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 or PEX21 receptors (PubMed:9094717, PubMed:20154681). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (PubMed:20154681). Mechanistically, PEX5 (or PEX21) receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:20154681).
messages: Interacts with PEX13 (via SH3 domain); forming the PEX13-PEX14 docking complex (PubMed:10087260, PubMed:20154681, PubMed:12453410). Interacts with PEX5 (via WxxxF/Y motifs) (PubMed:9094717, PubMed:20154681). Interacts with PEX7 (PubMed:9094717). Interacts with PEX9 (PubMed:27678487).
messages: Peroxisome membrane
messages: Present with 2570 molecules/cell in log phase SD medium.

559292:YLR240W
gene id: 559292:YLR240W
uniprot id: P22543
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal localization of the peripheral membrane protein PIB2 to the vacuolar membrane (PubMed:29698392, PubMed:26510498). Decreases activation of TORC1 in response to glutamine (PubMed:28483912).
messages: Autophosphorylated. Might also be phosphorylated by VPS15.
messages: Belongs to the PI3/PI4-kinase family.
messages: Component of the autophagy-specific VPS34 PI3-kinase complex I composed of VPS15, VPS30, VPS34, ATG14 and ATG38, and of the VPS34 PI3-kinase complex II composed of VPS15, VPS30, VPS34 and VPS38. Interacts directly with ATG38.
messages: Endosome membrane
messages: Phosphatidylinositol 3-kinase activity is directly dependent on VPS15 protein kinase activity.
messages: Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity.
messages: Present with 1080 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YJL056C
gene id: 559292:YJL056C
uniprot id: P47043
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Active in zinc-limited cells and repressed in replete cells. Zinc controls ZAP1 DNA binding activity.
messages: Contains 2 activation domains, embedded within larger zinc-responsive domains (ZRDs), designated AD1 and AD2, which are regulated independently by zinc. AD1 plays the primary role in zinc-responsive gene regulation, whereas AD2 is required for maximal expression of only a few target genes (PubMed:21177862). AD2 recruits coactivators less effectively than AD1 and is therefore only functional on some promoters (PubMed:22950018). AD2 is also important for ZAP1 activity under heat stress conditions (PubMed:21177862).
messages: Contains 2 zinc-responsive domains ZRD(AD1) and ZRD(AD2). Zinc binding to residues in ZRD(AD1) and ZRD(AD2) represses the activation function of AD1 and AD2, respectively.
messages: Induced by zinc. Regulates transcription of its own promoter in response to zinc through a positive autoregulatory mechanism.
messages: Nucleus
messages: Transcription regulator controlling zinc-responsive gene expression. Binds to zinc-responsive elements (ZREs) (consensus sequence 5'-ACCYYNAAGGT-3') in the promoter of target genes (PubMed:9786867). Recruits SWI/SNF, SAGA, and Mediator complexes as coactivators in a zinc-responsive manner (PubMed:22950018). Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation of the zinc uptake system genes ZTR1 and ZTR2 (PubMed:9271382). Positively regulates ETR1 expression, affecting mitochondrial function (PubMed:26711224).
messages: Uses 4 of its 7 zinc finger domains to contact the ZRE. 2 of these (ZF4 and ZF7) dominate the interaction by contacting the essential ACC--GGT ends, while the other 2 (ZF5 and ZF6) contact the 5 basepair central ZRE sequence. 2 zinc finger domains (ZF1 and ZF2) do not contact DNA, and a third ZF3 may be more important for interfinger protein-protein interactions (PubMed:12549926). ZF1 and ZF2 bind zinc in vitro but less stably than zinc fingers involved in DNA binding. ZF1 and ZF2 are critical for zinc regulation of activation domain 2 (AD2) and play a role in zinc sensing and consequent regulation of ZAP1 activity (PubMed:14517251). ZF1-ZF2 interactions stabilize the beta-beta-alpha folded repressed state of the ZF2 activation domain in the presence of cellular zinc excess (PubMed:16720702, PubMed:16483601). DNA binding is inhibited by zinc (PubMed:21799889).

559292:YDR089W
gene id: 559292:YDR089W
uniprot id: P38966
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Present with 172 molecules/cell in log phase SD medium.
messages: Regulatory subunit of the vacuolar transporter chaperone (VTC) complex (PubMed:27587415). The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (Probable). The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (Probable). PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (Probable). VTC5 interacts with the VTC complex to increase the rate of polyP production (PubMed:27587415).
messages: The VTC core complex is an integral membrane heterooligomer composed of the catalytic subunit VTC4 and the accessory subunits VTC1, VTC2 and VTC3. The complex exists in 2 different sub-complexes: VTC1-VTC2-VCT4 and VCT1-VTC3-VTC4. The VCT1-VTC3-VTC4 subcomplex is mostly found on the vacuolar membrane. The VTC1-VTC2-VCT4 subcomplex is observed in the cell periphery, probably ER and nuclear envelope, but localizes to the vacuole under phosphate starvation. Each subunit contains 3 transmembrane helices. VTC1 is a small membrane protein without hydrophilic domain. VTC2, VTC3 and VTC4 are related and have 2 hydrophilic domains that face the cytosol, an N-terminal SPX domain and the central core domain. The central core in VTC4 is the catalytic domain, with the essential catalytic lysine replaced by isoleucine and leucine in VTC2 and VTC3, respectively. The core complex associates with the regulatory subunit VTC5.
messages: Vacuole membrane

559292:YPR085C
gene id: 559292:YPR085C
uniprot id: Q06822
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ASA1 family.
messages: Component of the ASTRA chromatin-remodeling machinery complex composed of at least ASA1, RVB1, RVB2, TRA1, TEL2, TT1 and TTI2.
messages: Component of the ASTRA complex involved in chromatin remodeling.
messages: Nucleus

559292:YGR270W
gene id: 559292:YGR270W
uniprot id: P40340
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Chromosome
messages: Decreases the level of CSE4/CENP-A at centromeres (PubMed:32079723). Decreases internucleosome spacing at protein-coding genes (PubMed:25406467). Decreases localization of RNA polymerase II to the histone HTA1-HTB1 gene locus during the G1/S transition (PubMed:22156209). Decreases HTA1 RNA level (PubMed:19683497). Heterochromatin spreading downstream of the silent mating-type locus HMR (PubMed:16079223). Decreases cell population growth; simultaneous disruption of proteins required for maintaining centromere and kinetochore function, including CLH4 and CBF1, enhances the growth defect (PubMed:32079723).
messages: Functions as an ATP-dependent nucleosome disassembly factor that helps evict canonical histone H3 from the 5'-end of genes upon their induction (PubMed:25406467). Also contributes to kinetochore assembly by cooperating with SCM3 to load the histone H3 variant CSE4/CENP-A at centromeres (PubMed:32079723). Provides a chromatin boundary function at the 5'-end of genes that restricts access by RTT106 and thus prevents ectopic spreading of repressive chromatin into coding regions (PubMed:19683497, PubMed:25406467, PubMed:22156209). Also prevents heterochromatin spreading downstream of the silent mating-type locus HMR, this function is independent of the tRNA boundary element (PubMed:16079223). Contributes to appropriate cell cycle regulation of histone gene expression by recruiting RNA polymerase II to histone genes, and subsequent CDK1- and casein kinase II-dependent eviction from chromatin is required to promote transcriptional elongation (PubMed:22156209).
messages: Interacts with CSE4/CENP-A (PubMed:32079723). Interacts with SCM3 (PubMed:32079723). Interacts with SPT16 (PubMed:22156209). Interacts with POB3 (PubMed:22156209). Interacts with the casein kinase II complex subunits CKA1, CKA2, CKB1 and CKB2 (PubMed:22156209). Interacts with RNA polymerase II (PubMed:22156209). Interacts (via Bromo domain) with histone H3 (PubMed:16079223). Interacts (via Bromo domain) with histone H4 (PubMed:16079223).
messages: Nucleus
messages: Phosphorylated by CDK1 and casein kinase II during S-phase, which leads to its eviction from histone gene promoters and promotes histone gene transcription.
messages: Present with 172 molecules/cell in log phase SD medium.
messages: centromere

559292:YBR102C
gene id: 559292:YBR102C
uniprot id: P38261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO84 family.
messages: Bud
messages: Bud neck
messages: Component of the exocyst complex composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84. Interacts also with SNP1.
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis and to the budding site. Also involved in assembly of the spliceosome.
messages: secretory vesicle

559292:YGR173W
gene id: 559292:YGR173W
uniprot id: P53295
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Involved in ribosomal function.
messages: Present with 6200 molecules/cell in log phase SD medium.

559292:YGR021W
gene id: 559292:YGR021W
uniprot id: P53212
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Mitochondrion
messages: Present with 1780 molecules/cell in log phase SD medium.

559292:YGL147C
gene id: 559292:YGL147C
uniprot id: P05738
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL6 lines the binding pocket for eukaryotic elongation factor 2 (eEF2) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 52400 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL6 in yeast.

559292:YPR188C
gene id: 559292:YPR188C
uniprot id: Q06580
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Interacts with the IQ domain of MYO1.
messages: Present with 1127 molecules/cell in log phase SD medium.
messages: Regulatory light chain for the class II conventional myosin MYO1. May play a role in the disassembly of the MYO1 ring at the bud neck at the end of its contraction during cytokinesis.
messages: This chain binds calcium.

559292:YDL057W
gene id: 559292:YDL057W
uniprot id: Q07379
names: Disruption Phenotype
messages: Cells are viable and do not display any phenotype.

559292:YOL091W
gene id: 559292:YOL091W
uniprot id: Q12411
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MPC70 family.
messages: Interacts directly with MPC54, NUD1 and SPC42. Interacts with ADY3. Interacts with ADY4. Probable component of a SPB complex composed of ADY3, SSP1, DON1, MPC54, SPO21/MPC70, NUD1 and CNM67.
messages: Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May provide a meiosis-specific scaffold for the assembly of other proteins on spindle pole bodies (SPBs), and may be a limiting component for SPB formation.
messages: Meiosis-specific. Expressed during meiosis II, from 3 to 9 hours after induction of sporulation. Not expressed during mitosis.
messages: Prospore membrane
messages: spindle pole

559292:YMR227C
gene id: 559292:YMR227C
uniprot id: Q05021
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF7 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TAF7 is responsible for the recruitment of BDF1 to TATA element containing promoters.
messages: Nucleus
messages: Present with 1100 molecules/cell in log phase SD medium.
messages: TAF7 interacts with BDF1. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.

559292:YOL025W
gene id: 559292:YOL025W
uniprot id: Q92325
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Subunit
messages: Acts as an inhibitor of cullin neddylation and SCF complex assembly in vitro (PubMed:19942853). However in vivo experiments in other organisms strongly suggest that it acts as an essential regulator of SCF complex assembly.
messages: Assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (By similarity). Involved in the aging process. Longevity-assurance protein.
messages: Interacts with unneddylated cullin CDC53.
messages: Neddylated at Lys-16.
messages: Preferentially expressed in young cells.
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YCR028C
gene id: 559292:YCR028C
uniprot id: P25621
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Allantoate permease family.
messages: Cell membrane
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance.

559292:YFL037W
gene id: 559292:YFL037W
uniprot id: P02557
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Rhizoxin, an antibiotic that exhibits potent anti-mitotic activity against most eukaryotic cells except for yeasts, binds to beta tubulin.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

559292:YOR112W
gene id: 559292:YOR112W
uniprot id: Q12453
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the nuclear pore complex (NPC). Interacts with GSP1, LOS1, MSN5, NUP116 and TEF2.
messages: Component of the nuclear tRNA export machinery that my collect tRNA from the nuclear tRNA export receptors of the aminoacylation-dependent export and may deliver aminoacylated tRNAs to the translation machinery pathway at the nuclear pore complex.
messages: Cytoplasm
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YNL251C
gene id: 559292:YNL251C
uniprot id: P53617
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance.
messages: Present with 19600 molecules/cell in log phase SD medium.

559292:YKL140W
gene id: 559292:YKL140W
uniprot id: P34163
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Lipid droplet
messages: Mediates the hydrolysis of steryl esters (SE) (PubMed:10515935, PubMed:14640980, PubMed:15713625). Preferentially hydrolyzes ergosteryl and zymosteryl esters (PubMed:19111628). Required for mobilization of SEs from lipid particles/droplets, thereby playing a central role in lipid metabolism and sterol homeostasis. Sterol intermediates stored in SE and set free by SE hydrolases are recycled to the sterol biosynthetic pathway and converted to the final product, ergosterol, in the endoplasmic reticulum. Has also weak lipase activity toward triglycerides at neutral pH, however, the physiological relevance of this activity is unclear (PubMed:15922657, PubMed:19111628, PubMed:28866104).
messages: Membrane
messages: Not N-glycosylated.
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YDR191W
gene id: 559292:YDR191W
uniprot id: P53688
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.
messages: Nucleus
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YEL051W
gene id: 559292:YEL051W
uniprot id: P32610
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Present with 8500 molecules/cell in log phase SD medium.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:7797485, PubMed:7831318). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:7797485, PubMed:7831318).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:25971514, PubMed:27295975). Interacts with RAV1 and RAV2 components of the RAVE complex, which are essential for the stability and assembly of V-ATPase (PubMed:11283612).
messages: Vacuole membrane

559292:YLR395C
gene id: 559292:YLR395C
uniprot id: P04039
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: Present with 672 molecules/cell in log phase SD medium.

559292:YJL004C
gene id: 559292:YJL004C
uniprot id: P41544
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Necessary for the targeting of ARL3 to the Golgi. Involved in protein trafficking. May serve as a receptor for acetylated ARL3.
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YKL109W
gene id: 559292:YKL109W
uniprot id: P14064
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP4 encodes a regulatory subunit of the DNA-bound complex and seems to provide the principal transcriptional activation domains. Does not bind DNA directly, but augments the binding of HAP2 and HAP3.
messages: Component of the CCAT-binding factor (CBF or HAP complex II), which consists of one copy each of HAP2, HAP3, HAP4 and HAP5. The assembly of the HAP2-HAP3-HAP5 heteromer (HAP complex I) occurs in a one-step pathway and its binding to DNA is a prerequisite for the association of HAP4.
messages: Its expression is glucose-repressible.
messages: Nucleus

559292:YOR210W
gene id: 559292:YOR210W
uniprot id: P22139
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.
messages: Present with 5300 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YBR115C
gene id: 559292:YBR115C
uniprot id: P07702
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Binds 1 phosphopantetheine covalently.
messages: Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.
messages: Present with 7430 molecules/cell in log phase SD medium.

559292:YPR060C
gene id: 559292:YPR060C
uniprot id: P32178
names: Activity Regulation
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate (PubMed:2646272, PubMed:2187528, PubMed:10894726, PubMed:31498992, PubMed:9642265, PubMed:10428795). Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (Probable).
messages: Cytoplasm
messages: Each dimer has two allosteric binding sites that can bind the regulatory effectors tryptophan or tyrosine (PubMed:31498992, PubMed:2187528, PubMed:10428795, PubMed:9642265). Can bind either one tryptophan or one tyrosine, two tryptophan or two tyrosine or one tryptophan and one tyrosine, which differentially affect the catalytic activity (PubMed:31498992). Activated by tryptophan and subject to feedback inhibition by tyrosine (PubMed:10428795, PubMed:31498992, PubMed:2646272, PubMed:2187528). In the presence of both tryptophan and tyrosine, the enzyme is in the activated state (PubMed:2646272, PubMed:31498992).
messages: Homodimer.
messages: Not affected by altering tryptophan or tyrosine levels.

559292:YBR135W
gene id: 559292:YBR135W
uniprot id: P20486
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinase (CDC28) and is essential for its biological function.
messages: Forms a stable but non-covalent complex with the CDC28 protein and with a cyclin.
messages: Present with 8780 molecules/cell in log phase SD medium.

559292:YJL187C
gene id: 559292:YJL187C
uniprot id: P32944
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Bud neck
messages: Expressed periodically during the cell cycle, with a peak in late G1. Transcriptional repression requires ZDS1. Protein accumulation is also periodic, peaking during S/G2 and declining prior to and during nuclear division of the unperturbed cell cycle. Stabilized during a checkpoint response in G2. Induced during meiosis. Induced by ethanol (at protein level).
messages: Interacts with CLB2-CDC28. Partial hyperphosphorylation of SWE1 by CLB2-CDC28 stabilizes the ternary complex of SWE1 and CLB2-CDC28 and stimulates kinase activity of SWE1 in a positive feedback loop, maintaining CLB2-CDC28 in the tyrosine-phosphorylated state. Fully hyperphosphorylated SWE1 dissociates from CLB2-CDC28. Interacts with HSL7, KCC4 and MET30.
messages: Nucleus
messages: Phosphorylated progressively by CLA4, CLB2-CDC28 and CDC5. CLA4-dependent phosphorylation occurs in late S phase, followed by phosphorylation by CLB2-CDC28 in early G2, when the levels of mitotic CLB2 increases. This phosphorylation is critical for triggering subsequent SWE1-CDC5 interaction and CDC5-dependent phosphorylation. The resulting cumulative hyperphosphorylation down-regulates SWE1 by targeting it for ubiquitin-mediated degradation. This stepwise phosphorylation is thought to be a mechanism to integrate the different checkpoint requirements before entry into mitosis.
messages: Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-19'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Inhibits the activity of B-type cyclins in replication initiation strongly for CLB2, moderately for CLB3 and CLB4, and there is no apparent inhibition for CLB5 and CLB6, correlating with the normal expression timing of those cyclins. Hyperphosphorylation and degradation of SWE1 when all checkpoint requirement are met releases CLB2-CDC28 from inhibition and allows for progression through the cell cycle. SWE1-dependent CDC28 phosphorylation is also required for pachytene arrest upon activation of the recombination checkpoint during meiosis. Also involved in the regulation of nitrogen starvation- and short chain alcohol-induced filamentous growth, or filamentous differentiation in response to slowed DNA synthesis. Can act both on serines and on tyrosines.
messages: Ubiquitinated by the SCF(MET30) complex, leading to its degradation by the proteasome.

559292:YNL141W
gene id: 559292:YNL141W
uniprot id: P53909
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. Also exhibits a low activity towards N(6)-substituted adenines that are commonly known as the plant hormones cytokinins.
messages: Cytoplasm
messages: Nucleus
messages: Present with 20700 molecules/cell in log phase SD medium.
messages: Probably ubiquitinated when cells enter quiescence in response to nutrient limitation, since it is specifically degraded via a process requiring the F-box protein SAF1 and components of the SKP1-Cullin-F-box complex.
messages: Reduced when grown in a poor nitrogen source medium and strongly down-regulated when cells enter quiescence under nutrient-limiting conditions.

559292:YKR035W-A
gene id: 559292:YKR035W-A
uniprot id: P69771
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Probably acts as a peripherally associated component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruits late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Regulates the membrane association of VPS4. Can stimulate VPS4 ATPase activity directly or via VTA1.
messages: Endomembrane system
messages: Endosome membrane
messages: Present with 2440 molecules/cell in log phase SD medium.
messages: Self-associates. Interacts with VPS4 and VTA1. Interacts with IST1.

559292:YMR303C
gene id: 559292:YMR303C
uniprot id: P00331
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Present with 1620 molecules/cell in log phase SD medium.
messages: Repressed by glucose.
messages: This isozyme preferentially catalyzes the conversion of ethanol to acetaldehyde. Acts on a variety of primary unbranched aliphatic alcohols.

559292:YJR148W
gene id: 559292:YJR148W
uniprot id: P47176
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as well as lysine and proline as the amino donors. Involved in cell cycle regulation.
messages: Cytoplasm
messages: Down-regulated in the presence of repressive nitrogen sources (glutamine) and derepressed in secondary non-repressive nitrogen sources such as GABA. Highly expressed on cultures with isoleucine, leucine and valine as sole nitrogen source (catabolic conditions).
messages: Highly expressed during stationary phase, down-regulated during logarithmic phase of growth.
messages: Present with 25900 molecules/cell in log phase SD medium.

559292:YLR404W
gene id: 559292:YLR404W
uniprot id: Q06058
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the seipin family.
messages: By calcium shortage.
messages: Endoplasmic reticulum membrane
messages: Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size (PubMed:18093937, PubMed:18250201). Facilitates initiation of LD formation, and ensures that vectorial budding of LDs from the ER is directed towards the cytoplasm (PubMed:25540432).
messages: Present with 846 molecules/cell in log phase SD medium.
messages: Produces supersized LDs that are up to 50 times the volume of those in wild-type cells.

559292:YBR229C
gene id: 559292:YBR229C
uniprot id: P38138
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.
messages: Endoplasmic reticulum
messages: Heterodimer of a catalytic subunit alpha (ROT2) and a subunit beta (GTB1).
messages: Inhibited by glucose, maltose and nigerose, and by the antibiotic deoxynojirimycin.
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YGR129W
gene id: 559292:YGR129W
uniprot id: P53277
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NTC complex (or PRP19-associated complex), composed of at least CEF1, CLF1, ISY1, NTC20, SNT309, SYF1, SYF2, and PRP19. The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex (or CEF1-associated complex) reminiscent of a late-stage spliceosome composed also of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, LEA1, MSL1, PRP8, PRP9, PRP11, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNU114, SPP2, RSE1 and YJU2. Interacts with CEF1, CLF1 and SYF1.
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing and cell cycle control. As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. The cell cycle arrest of SYF2 defective cells may be due to the inefficient splicing of TUB1.
messages: Nucleus
messages: Present with 1670 molecules/cell in log phase SD medium.

559292:YAL018C
gene id: 559292:YAL018C
uniprot id: P31379
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A combined deletion of the LDS proteins RRT8, LDS1 and LDS2 fails to incorporate dityrosine and another yet uncharacterized component in the outer spore wall.
messages: Belongs to the LDS family.
messages: Involved in spore wall assembly.
messages: Lipid droplet
messages: Prospore membrane
messages: Spore wall

559292:YDL170W
gene id: 559292:YDL170W
uniprot id: P26370
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: GABA-dependent positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2).
messages: Nucleus
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: UGA3 proteins associate in oligomers, at least in the presence of inducer.

559292:YER180C-A
gene id: 559292:YER180C-A
uniprot id: Q3E784
names: Similarity
names: Subunit
messages: Belongs to the SLO1 family.
messages: Interacts with ARL3.

559292:YAL058W
gene id: 559292:YAL058W
uniprot id: P27825
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum membrane
messages: In contrast with other calnexin, yeast CNE1 does not seem to bind calcium.
messages: Interacts with MPD1.
messages: Interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
messages: Present with 4760 molecules/cell in log phase SD medium.

559292:YLR157W-E
gene id: 559292:YLR157W-E
uniprot id: P0CF00
names: Miscellaneous
messages: There are 3 tandem-duplicated genes coding for this protein in S.cerevisiae (YLR156W, YLR159W and YLR161W). Additionally, a fourth copy has been disrupted by a Ty1 retrotransposon, which led to the prediction of the 2 dubious ORFs YLR157W-D and YLR157W-E.

559292:YGR193C
gene id: 559292:YGR193C
uniprot id: P16451
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.
messages: Mitochondrion matrix
messages: Present with 414 molecules/cell in log phase SD medium.
messages: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.

559292:YBR002C
gene id: 559292:YBR002C
uniprot id: P35196
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Endoplasmic reticulum membrane
messages: Forms an active dehydrodolichyl diphosphate synthase complex with NUS1.
messages: Mainly expressed in the early logarithmic phase.
messages: Present with 8970 molecules/cell in log phase SD medium.
messages: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).

559292:YJR028W
gene id: 559292:YJR028W
uniprot id: P47099
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-JR2 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YHR184W
gene id: 559292:YHR184W
uniprot id: P38871
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts directly with ADY3. Probable component of a spindle pole body (SPB) complex composed of ADY3, SSP1, DON1, MPC54, SPO21/MPC70, NUD1 and CNM67.
messages: Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May be required for the formation of ADY3 and DON1-containing protein coats at the leading edge of the PSMs during meiosis II.
messages: Meiosis-specific. Expressed from 3 to 9 hours after induction of sporulation. Not expressed during mitosis.
messages: Phosphorylated.
messages: Prospore membrane

559292:YPR070W
gene id: 559292:YPR070W
uniprot id: Q12321
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. MED1 interacts directly with MED4 and MED7.
messages: Nucleus
messages: Present with 4675 molecules/cell in log phase SD medium.

559292:YCR011C
gene id: 559292:YCR011C
uniprot id: P25371
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Endoplasmic reticulum membrane
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YLR467W
gene id: 559292:YLR467W
uniprot id: P0CX20
uniprot id: P0CX21
uniprot id: P0CX22
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YOR229W
gene id: 559292:YOR229W
uniprot id: Q12206
names: Function
names: Miscellaneous
messages: Present with 3750 molecules/cell in log phase SD medium.
messages: Transcriptional modulator with roles in meiotic regulation and silencing.

559292:YNL130C-A
gene id: 559292:YNL130C-A
uniprot id: Q3E808
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Increases cellular tolerance to 2-deoxy-glucose.
messages: Mitochondrion

559292:YBR107C
gene id: 559292:YBR107C
uniprot id: P38265
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-L/IML3 family.
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Forms a heterodimer with IML3 (PubMed:12589047, PubMed:24075991). CHL4-IML3 is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). Interacts with CHL4 and CTF19 (PubMed:12589047).
messages: Nucleus
messages: Present with 125 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YCR051W
gene id: 559292:YCR051W
uniprot id: P25631
names: Miscellaneous
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YMR285C
gene id: 559292:YMR285C
uniprot id: Q03264
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Involved in pre-rRNA processing. Required for the final stage of 3'-end maturation of 5.8S rRNA at site E.
messages: Nucleus
messages: Present with 3570 molecules/cell in log phase SD medium.

559292:YLR430W
gene id: 559292:YLR430W
uniprot id: Q00416
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair.
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Interacts with RAD2, RNT1 and RPB1. Binds to multiple snoRNAs.
messages: Nucleus
messages: Present with 125 molecules/cell in log phase SD medium.

559292:YNL168C
gene id: 559292:YNL168C
uniprot id: P53889
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAH family.
messages: In high salinity conditions.
messages: Mitochondrion
messages: Present with 2550 molecules/cell in log phase SD medium.

559292:YPL118W
gene id: 559292:YPL118W
uniprot id: Q02950
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. bS1m functionally interacts with the 5'-UTR of mitochondrial mRNAs.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YNL227C
gene id: 559292:YNL227C
uniprot id: P53863
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 2310 molecules/cell in log phase SD medium.

559292:YDL225W
gene id: 559292:YDL225W
uniprot id: Q07657
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SHS1 and rearranges to a cortical collar of highly ordered filaments at the mother-bud-neck. A complex formed by CDC3, CDC10, CDC11 and CDC12 is capable of forming long filaments in vitro and the components seem to be present in a 2:2:2:2 arrangement in vivo. The filaments are proposed to be formed by the end-to-end polymerization of CDC3-CDC12-CDC11 complexes with CDC10 serving as a bridge to bundle the polymers into paired filaments. Component of the GIN4 complex composed of at least BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. Self-associates. Interacts with CDC11 and SPA2.
messages: Membrane
messages: Phosphorylated by GIN4 and CLA4. Phosphorylation state is essential for septin ring dynamics during telophase.
messages: Present with 5620 molecules/cell in log phase SD medium.
messages: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 min before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
messages: Sumoylated during mitosis on the mother cell side of the bud neck. Sumoylation probably plays a central role in regulating septin ring disassembly during the cell cycle.

559292:YNL113W
gene id: 559292:YNL113W
uniprot id: P28000
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Directly interacts with the RPC40 subunit.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.
messages: Present with 8680 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR023W
gene id: 559292:YDR023W
uniprot id: P07284
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser) (PubMed:3031581). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (Probable).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer; the tRNA molecule probably binds across the dimer (PubMed:3031581). Interacts with ABP140; interaction is required for the tRNA N(3)-methylcytidine methyltransferase activity of ABP140 (PubMed:28003514).

559292:YGL169W
gene id: 559292:YGL169W
uniprot id: P32579
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Causes increased leaky scanning through AUG codons, +1 frameshifting, and read-through of stop codons. Also causes progressive telomere shortening.
messages: Cytoplasm
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.
messages: telomere

559292:YPR071W
gene id: 559292:YPR071W
uniprot id: Q12346
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

559292:YGL136C
gene id: 559292:YGL136C
uniprot id: P53123
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Loses mitochondrial DNA with high frequency.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 2791 (Um2791) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

559292:YJR014W
gene id: 559292:YJR014W
uniprot id: P47089
names: Domain
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DENR family.
messages: Cytoplasm
messages: Interacts with the 40S ribosomal subunit.
messages: Present with 21600 molecules/cell in log phase SD medium.
messages: The SUI1 domain may be involved in RNA binding.

559292:YJL024C
gene id: 559292:YJL024C
uniprot id: P47064
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.
messages: Present with 1240 molecules/cell in log phase SD medium.

559292:YJL039C
gene id: 559292:YJL039C
uniprot id: P47054
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NUP186/NUP192/NUP205 family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP192 interacts with NIC96.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs.
messages: Present with 2520 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YCR027C
gene id: 559292:YCR027C
uniprot id: P25378
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rheb family.
messages: Cell membrane
messages: Interacts with BTN2.
messages: Involved in the regulation of arginine and lysine uptake. Acts through the CAN1 permease.
messages: Present with 1600 molecules/cell in log phase SD medium.

559292:YOR192C-A
gene id: 559292:YOR192C-A
uniprot id: Q12439
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YOR215C
gene id: 559292:YOR215C
uniprot id: Q12032
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM41 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion
messages: Present with 2870 molecules/cell in log phase SD medium.

559292:YMR182W-A
gene id: 559292:YMR182W-A
uniprot id: Q8TGS7
names: Subcellular Location Annotation
messages: Membrane

559292:YIL135C
gene id: 559292:YIL135C
uniprot id: P40463
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Can suppress the synthetic lethality of the hal3 sit4 double mutation when overexpressed, suggesting that it is involved in the G1-S transition.
messages: Cytoplasm
messages: Present with 2200 molecules/cell in log phase SD medium.
messages: To yeast MFL3.

559292:YML058W-A
gene id: 559292:YML058W-A
uniprot id: Q6Q5K6
names: Function
names: Induction
names: Subcellular Location Annotation
messages: By replication arrest and DNA damage. Repressed by CYC8, RFX1 and TUP1.
messages: Cytoplasm
messages: Involved in the MEC1-mediated checkpoint response to DNA damage and replication arrest.
messages: Nucleus

559292:YER051W
gene id: 559292:YER051W
uniprot id: P40034
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Does not demethylate H3 'Lys-4' nor 'Lys-79'.
messages: Nucleus
messages: Present with 784 molecules/cell in log phase SD medium.
messages: The JmjC domain mediates the demethylation activity.

559292:YEL040W
gene id: 559292:YEL040W
uniprot id: P32623
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 16 family.
messages: Membrane
messages: Probable glycosidase that plays a role in cell wall architecture. Required for the transfer of chitin to 1,6-beta-glucan in the cell wall.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YOL128C
gene id: 559292:YOL128C
uniprot id: Q12222
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Required for heat stress-instigated phosphorylation of BCY1 which is involved in cell wall integrity signaling. Regulates activity of MSN2, a transcription factor that binds to the stress-response element (STRE). Probably promotes formation of a complex between MSN2 and DNA. Regulates the stability of ROG1.

559292:YJL071W
gene id: 559292:YJL071W
uniprot id: P40360
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Feedback inhibition by L-arginine.
messages: Interacts with the acetylglutamate kinase chain of AGR5,6.
messages: Mitochondrion
messages: N-acetylglutamate synthase involved in arginine biosynthesis.
messages: Present with 112 molecules/cell in log phase SD medium.

559292:YNR021W
gene id: 559292:YNR021W
uniprot id: P53723
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0674 family.
messages: Endoplasmic reticulum membrane
messages: Present with 34906 molecules/cell in log phase SD medium.

559292:YGR041W
gene id: 559292:YGR041W
uniprot id: P53226
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be involved in positioning the proximal bud pole signal.
messages: N- and O-glycosylated.
messages: Present with 952 molecules/cell in log phase SD medium.
messages: To yeast BUD8.

559292:YLL063C
gene id: 559292:YLL063C
uniprot id: Q12226
names: Function
names: Similarity
messages: Belongs to the trichothecene 3-O-acetyltransferase family.
messages: Trichothecene 3-O-acetyltransferase involved in self-protection against trichothecenes, mycotoxins acting as eukaryotic protein synthesis inhibitors. Its existence is surprising in a non-trichothecene producer organism which needs no self-protection again endogenic trichothecenes. The persistence of this non-essential gene may be due to a selective advantage that it may confer, like a resistance to exogenic trichothecenes.

559292:YDR285W
gene id: 559292:YDR285W
uniprot id: P31111
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus
messages: Present with 391 molecules/cell in log phase SD medium.
messages: Required for meiotic chromosome synapsis and cell cycle progression. May act as a molecular zipper to bring homologous chromosomes in close apposition. ZIP1 may encode the transverse filaments of the synaptonemal complex.

559292:YIL111W
gene id: 559292:YIL111W
uniprot id: P00425
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: By low oxygen levels (hypoxia) at the level of transcription. Repressed by ROX1 in the presence of oxygen (PubMed:2546055). Not expressed until the oxygen concentration is below 0.5 uM O(2) (PubMed:9169434).
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:2986105). COX5A is the predominant subunit V during aerobic/normoxic growth, it gets replaced by COX5B under anaerobic/hypoxic conditions (PubMed:2546055). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: Present with 2250 molecules/cell in log phase SD medium.

559292:YGL244W
gene id: 559292:YGL244W
uniprot id: P53064
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PAF1 complex which consists of at least CDC73, CTR9, LEO1, PAF1 and RTF1.
messages: Present with 6510 molecules/cell in log phase SD medium.
messages: The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. Important for TATA site selection by TBP. Directly or indirectly regulates the DNA-binding properties of SPT15, the TATA box-binding protein, and the relative activities of different TATA elements.
messages: nucleoplasm

559292:YJR056C
gene id: 559292:YJR056C
uniprot id: P47115
names: Miscellaneous
messages: Present with 1890 molecules/cell in log phase SD medium.

559292:YBR183W
gene id: 559292:YBR183W
uniprot id: P38298
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alkaline ceramidase that hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse activity as acyl-CoA-independent ceramide synthase, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide (PubMed:10702247, PubMed:10900202, PubMed:11694577, PubMed:24866405). Preferentially uses very long chain fatty acids (C-24 and C-26) in vivo compared to C-16 in vitro (PubMed:24866405).
messages: Belongs to the alkaline ceramidase family.
messages: Endoplasmic reticulum membrane

559292:YDL223C
gene id: 559292:YDL223C
uniprot id: Q07653
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Conjugated with HUB1. HUB1 has not the classical C-terminal Gly residue, so it is still unknown how conjugation may occur.
messages: Cytoplasm
messages: Polarity-determining protein which forms a conjugate with the ubiquitin-like modifier HUB1. Involved in bud site selection and cellular morphogenesis during conjugation. Required for survival during stationary phase.

559292:YIL037C
gene id: 559292:YIL037C
uniprot id: P40534
names: Induction
names: Subcellular Location Annotation
messages: By pheromone.
messages: Membrane

559292:YLR227C
gene id: 559292:YLR227C
uniprot id: Q05955
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CNM67, SPO21/MPC70 and NUD1.
messages: Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May be required to stabilize the outer plaque of the spindle pole body (SPB).
messages: Meiosis-specific.
messages: spindle pole body

559292:YOL041C
gene id: 559292:YOL041C
uniprot id: Q08208
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM34 family.
messages: Involved in pre-25S rRNA processing.
messages: Present with 5910 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YCR068W
gene id: 559292:YCR068W
uniprot id: P25641
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Glycosylated.
messages: Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: Prevacuolar compartment membrane
messages: multivesicular body membrane

559292:YMR053C
gene id: 559292:YMR053C
uniprot id: P46679
names: Similarity
names: Subunit
messages: Interacts with SIN3.
messages: To yeast STB6.

559292:YNL036W
gene id: 559292:YNL036W
uniprot id: P53615
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Encodes a substrate for the non-classical protein export pathway for proteins that lack a cleavable signal sequence.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Present with 2330 molecules/cell in log phase SD medium.
messages: Transcription and activity down-regulated at elevated CO(2) concentrations.

559292:YDR122W
gene id: 559292:YDR122W
uniprot id: P13185
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with SEC9 and SRO7.
messages: Present with 279 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.

559292:YKR025W
gene id: 559292:YKR025W
uniprot id: P36121
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC53/RPC4. RPC53/RPC4, RPC37/RPC5 and RPC11/RPC10 probably form a Pol III subcomplex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.
messages: Nucleus
messages: Present with 1590 molecules/cell in log phase SD medium.

559292:YBR264C
gene id: 559292:YBR264C
uniprot id: P38146
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Present with 1360 molecules/cell in log phase SD medium.
messages: Protein transport. Probably involved in vesicular traffic (By similarity). Specifically binds guanine nucleotides.
messages: Via its C-terminal end interacts with the Rab GDP dissociation inhibitor (RabGDI). Interacts with YIF1, YIP3, YIP4 and YIP5.

559292:YKL137W
gene id: 559292:YKL137W
uniprot id: P36064
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CMC family.
messages: Interacts with CMC2.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Present with 259 molecules/cell in log phase SD medium.
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. Binds copper. May be involved in copper trafficking and distribution to mitochondrial COX and SOD1.
messages: The twin Cx9C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.

559292:YJL128C
gene id: 559292:YJL128C
uniprot id: P08018
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation by SSK2 or SSK22. Ser/Thr phosphorylation is also necessary for SHO1-mediated activation.
messages: Alternative way of activation involves binding the proline-rich motif to the SH3 domain of SHO1.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Cytoplasm
messages: Interacts with NBP2, PTC1, SHO1 and STE11.
messages: Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Seems to phosphorylate HOG1 on a tyrosine residue.
messages: Present with 2160 molecules/cell in log phase SD medium.

559292:YJL163C
gene id: 559292:YJL163C
uniprot id: P46996
names: Subcellular Location Annotation
messages: Membrane

559292:YGR194C
gene id: 559292:YGR194C
uniprot id: P42826
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm
messages: Impairs growth in culture media with D-xylulose as the sole carbon source.
messages: Present with 3460 molecules/cell in log phase SD medium.
messages: Xylulose kinase necessary for growth in culture media with D-xylulose as the solecarbon source.

559292:YPL192C
gene id: 559292:YPL192C
uniprot id: Q08931
names: Caution
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: By pheromone. Expression is controlled by the STE12 transcription factor that binds to pheromone-response cis-elements (PREs) in the promoter of target genes.
messages: Interacts with KAR5.
messages: Nucleus outer membrane
messages: Required for the fusion of nuclear envelopes during mating, ensuring proper karyogamy. Plays a role in the initiation of outer nuclear envelope fusion.
messages: Was originally shown to be localized in the inner nuclear membrane by using a truncated protein (PubMed:12514182). Was used as an inner nuclear membrane marker (PubMed:17996101, PubMed:18660802 and PubMed:19369416). However, more recent studies showed that it is localized in the nuclear outer membrane, which is consistent with a function in the initiation of nuclear fusion (PubMed:19297527 and PubMed:19570912).
messages: spindle pole body

559292:YKL209C
gene id: 559292:YKL209C
uniprot id: P12866
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. Alpha-factor sex pheromone exporter (TC 3.A.1.206) family.
messages: Degraded via the ubiquitin system.
messages: Membrane
messages: STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone.

559292:YJL098W
gene id: 559292:YJL098W
uniprot id: P40856
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Associates with the SIT4 phosphatase in a cell cycle dependent manner. May be directly or indirectly involved in SIT4-dependent functions in budding and in normal G1 cyclin expression.
messages: Belongs to the SAPS family.
messages: Hyperphosphorylated in the absence of SIT4.
messages: Present with 11200 molecules/cell in log phase SD medium.

559292:YCL049C
gene id: 559292:YCL049C
uniprot id: P25577
names: Miscellaneous
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YGL027C
gene id: 559292:YGL027C
uniprot id: P53008
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically (PubMed:9363442). Seems to play a role in beta-1,6-glucan synthesis (PubMed:8576053).
messages: Displays phenotypes characteristic of cell wall defects such as hypersensitivity to calcofluor white and resistance to K1 killer toxin, and results in a 50% reduction of cell wall beta-1,6-glucan level (PubMed:9363442). Abolishes glucosidase I activity (PubMed:9363442).
messages: Endoplasmic reticulum membrane
messages: Miglitol is an effective inhibitor at 1 mM.
messages: N-glycosylated.
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YLR407W
gene id: 559292:YLR407W
uniprot id: Q06070
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Deletion results in antifungal drug fluconazole-resistant phenotype.
messages: Present with 3140 molecules/cell in log phase SD medium.
messages: cell cortex

559292:YOR332W
gene id: 559292:YOR332W
uniprot id: P22203
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase E subunit family.
messages: Homodimer (PubMed:8626613). V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:2145285, PubMed:8416931, PubMed:25971514, PubMed:18055462, PubMed:27295975). Interacts with VMA5; the interaction is direct (PubMed:15751969). Interacts with VMA10; the interaction is direct (PubMed:15751969). Interacts with RAV1 and RAV2 components of the RAVE complex, which are essential for the stability and assembly of V-ATPase (PubMed:11283612).
messages: Present with 16134 molecules/cell in log phase SD medium.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8416931). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:8416931, PubMed:2145285).
messages: Vacuole membrane

559292:YGR071C
gene id: 559292:YGR071C
uniprot id: P53246
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VID22 family.
messages: Exhibits cold sensitivity, a significant increase in cells with fragmented vacuoles, internal accumulation of precursor CPY, increased glycogen accumulation, and displays elongated buds.
messages: Involved in vacuolar processing and morphology.
messages: Nucleus
messages: Present with 1050 molecules/cell in log phase SD medium.

559292:YPR152C
gene id: 559292:YPR152C
uniprot id: Q06525
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the precatalytic spliceosomal complex B. Interacts with PRP19.
messages: Component of the spliceosome involved in mRNA processing.
messages: Nucleus
messages: Present with 1310 molecules/cell in log phase SD medium.

559292:YHR088W
gene id: 559292:YHR088W
uniprot id: P38805
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Essential protein. Required for biogenesis of the 60S ribosomal subunit.
messages: Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.
messages: Present with 784 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YKR036C
gene id: 559292:YKR036C
uniprot id: P36130
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat MDV1/CAF4 family.
messages: Interacts with DNM1, FIS1 and MDV1, components of the mitochondrial fission machinery. Interacts via its WD repeats with DNM1. Interacts with CCR4 and NOT1, components of the CCR4-NOT complex. It is however not a component of the 1.0 MDa CCR4-NOT core complex, but appears to be part of a less characterized, 1.9 MDa CCR4-NOT complex. Interacts with DBF2, another likely component of the 1.9 MDa complex. Interacts with SRB9 and SRB10, components of the SRB8-11 complex.
messages: Involved in mitochondrial fission. Has a partially redundant function to MDV1 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Plays a key role in determining the polarized localization of those DNM1 clusters that are not immediately involved in the mitochondrial fission process.
messages: Mitochondrion outer membrane
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YOR180C
gene id: 559292:YOR180C
uniprot id: Q08558
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: By oleate, through the binding of the OAF1-PIP2 transcriptional activator complex to its promoter ORE element. Expression is also induced during ammonia pulses in yeast colonies, at the beginning of detectable ammonia production.
messages: Interacts with ECI1.
messages: Peroxisomal di-isomerase that is involved in fatty acid metabolism enzyme by converting 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs (PubMed:10381339, PubMed:10455114). Required for ECI1 to be locazed to the peroxisome (PubMed:10381339, PubMed:11302517).
messages: Peroxisome

559292:YGL004C
gene id: 559292:YGL004C
uniprot id: P53196
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Is not a genuine component of the 26S proteasome, but an auxiliary factor that interacts with the proteasomal ATPase of 19S regulatory particle (RP). Acts as a chaperone which regulates the highly structured assembly of the 19S regulatory particle. Involved in the substrate specificity of the 26S proteasome and is especially involved in the degradation of ubiquitinated GCN4. May contribute to the stability of the 26S proteasome in some stress conditions.
messages: Associates with the 19S proteasome regulatory particle (RP). Interacts directly with RPT5 and RPT6.
messages: Belongs to the WD repeat PAAF1/RPN14 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2210 molecules/cell in log phase SD medium.

559292:YNL081C
gene id: 559292:YNL081C
uniprot id: P53937
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YNR056C
gene id: 559292:YNR056C
uniprot id: P53744
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Membrane
messages: Transport into the cell of 7-keto 8-aminopelargonic acid.

559292:YLR260W
gene id: 559292:YLR260W
uniprot id: Q06147
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively (PubMed:9677363, PubMed:11102354, PubMed:12493772, PubMed:25345524). Redundant to LCB4, is only responsible for few percent of the total activity (PubMed:9677363). Involved in the biosynthesis of sphingolipids and ceramides (PubMed:9677363, PubMed:25345524). Involved in heat-induced transient cell cycle arrest (PubMed:11056159). Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling (PubMed:11102354, PubMed:11278643). Involved in heat-stress resistance (PubMed:11056159).
messages: Golgi apparatus membrane
messages: Present with 1760 molecules/cell in log phase SD medium.

559292:YLR417W
gene id: 559292:YLR417W
uniprot id: Q06696
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (PubMed:12194858, PubMed:15469844, PubMed:15329733). The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (PubMed:12194858). The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (PubMed:12194858). Involved in the trafficking of the plasma membrane ATPase (PubMed:12194858). Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (PubMed:15029239).
messages: Component of the endosomal sorting required for transport complex II (ESCRT-II), which consists of 2 copies of VPS25, 1 copy of SNF8, and 1 copy of VPS36 (PubMed:15329733, PubMed:15469844). The ESCRT-II complex interacts directly with the VPS20 subunit of the ESCRT-III complex (PubMed:12194858). Binds ubiquitin (PubMed:15029239).
messages: Cytoplasm
messages: Endosome membrane
messages: Present with 2470 molecules/cell in log phase SD medium.
messages: The second RanBP2-type zinc-finger is functional and binds ubiquitin.

559292:YPR081C
gene id: 559292:YPR081C
uniprot id: Q06817
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:23816885). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (By similarity).
messages: Cytoplasm
messages: GRS1, which appears to be a duplication of GRS2, is necessary and sufficient for both mitochondrial and cytoplasmic glycyl-tRNA synthetase activities, suggesting that GRS2 may not be essential.
messages: Homodimer.
messages: Present with 2290 molecules/cell in log phase SD medium.

559292:YMR159C
gene id: 559292:YMR159C
uniprot id: Q03818
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG16 family.
messages: Homodimer. Part of the 350 kDa complex which is at least composed of ATG5, ATG12 and ATG16. Several units of each may be present in this complex. Interacts directly with ATG12.
messages: Preautophagosomal structure membrane
messages: Present with 573 molecules/cell in log phase SD medium.
messages: Stabilizes the ATG5-ATG12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.

559292:YDR384C
gene id: 559292:YDR384C
uniprot id: Q12359
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Cell membrane
messages: Expression is under the control of the ADR1, CAT8, and GCN4 transcription factors. Also induced by external ammonia and in rho(0) cells.
messages: Transporter protein required for ammonia export. Induced in rho(0) cells, probably to eliminate the excess ammonia that arises because of a potential defect in ammonia assimilation in those cells.

559292:YNL078W
gene id: 559292:YNL078W
uniprot id: P53939
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Expression is regulated by the ACE2 and SWI5 transcription factors.
messages: Interacts with CBF2, GIS1, NAP1, PRM8, REI1, SHS1 and SMT3.
messages: May be involved in a mitotic signaling network. Binds sumoylated proteins and may stabilize SUMO chains.
messages: Present with 504 molecules/cell in log phase SD medium.
messages: cell cortex

559292:YOL162W
gene id: 559292:YOL162W
uniprot id: P0CF19
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Allantoate permease family.
messages: Could be the product of a pseudogene. This is the C-terminal part of an allantoate permease subfamily member protein. Strain S288c has a stop codon in position 170, which disrupts the gene coding for this protein and produces two ORFs YOL163W and YOL162W.
messages: Membrane

559292:YOR092W
gene id: 559292:YOR092W
uniprot id: Q99252
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: May be involved in cell wall organization and biogenesis.

559292:YLR083C
gene id: 559292:YLR083C
uniprot id: P32802
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Endosome membrane
messages: Vacuole membrane
messages: With TMN2 and TMN3, plays a critical role in the late stages of a nutrient-controlled pathway notably regulating FLO11 gene expression. Acts downstream of RAS2 and TOR. Essential for cell adhesion and filamentous growth. May play a role as effector of cellular copper homeostasis.

559292:YNL153C
gene id: 559292:YNL153C
uniprot id: P53900
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Present with 7470 molecules/cell in log phase SD medium.

559292:YIL076W
gene id: 559292:YIL076W
uniprot id: P40509
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with the ESCRT-0 subunit VPS27.
messages: Present with 23100 molecules/cell in log phase SD medium.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

559292:YOR359W
gene id: 559292:YOR359W
uniprot id: Q08831
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTS1 family.
messages: Monomer. Binds to RNA.
messages: P-body
messages: Present with 3200 molecules/cell in log phase SD medium.
messages: RNA-binding protein involved in post-transcriptional regulation through transcript degradation of SRE (SMG-recognition elements) bearing mRNAs.
messages: The SAM domain is essential for RNA-binding.
messages: cytosol

559292:YLR242C
gene id: 559292:YLR242C
uniprot id: Q06541
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Regulates also the sphingolipid metabolism. Required for growth during anaerobiosis and sterol uptake.

559292:YLR050C
gene id: 559292:YLR050C
uniprot id: Q12155
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YJL031C
gene id: 559292:YJL031C
uniprot id: Q00618
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4.
messages: Heterodimer of an alpha and a beta subunit.
messages: Was originally thought to be MAD2.

559292:YHR142W
gene id: 559292:YHR142W
uniprot id: P38843
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes CHS3 localization to the bud neck with increased protein localization to the ER membrane.
messages: Belongs to the CHS7 family.
messages: Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: Interacts with CHS3.

559292:YMR104C
gene id: 559292:YMR104C
uniprot id: P18961
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by phytosphingosine (PHS), a sphingoid long chain base. Activated by PKH2 phosphorylation. Kinase activity is regulated by TOR2 via direct phosphorylation of Ser-641 and Thr-659.
messages: Autophosphorylated (By similarity). Phosphorylated by PKH2 and TOR2.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
messages: Cytoplasm
messages: May act as a downstream kinase in the sphingolipid-mediated signaling pathway. Plays an essential role in the proliferation of yeast cells. Involved in a signaling pathway, required for optimal cell wall integrity, that acts in parallel with the PKC1-SLT2-dependent pathway. A substrate of TOR complex 2 (TORC2) and required for TORC2 to regulate spatial aspects of cell growth. Phosphorylation of residue Thr-501 is indispensable for function.
messages: Nucleus
messages: Present with 1310 molecules/cell in log phase SD medium.

559292:YPR133C
gene id: 559292:YPR133C
uniprot id: Q06505
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IWS1 family.
messages: Interacts with ABD1, RBP1, SPT5 and SPT6.
messages: Nucleus
messages: Present with 2830 molecules/cell in log phase SD medium.
messages: Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.

559292:YFL028C
gene id: 559292:YFL028C
uniprot id: P43569
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cytoplasm
messages: Interacts with CCR4 and SSN2.
messages: Nucleus
messages: Present with 1620 molecules/cell in log phase SD medium.

559292:YML029W
gene id: 559292:YML029W
uniprot id: Q03714
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the HRD1 ubiquitin ligase complex which contains the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873066). Within the complex, interacts directly with HRD1 (via N-terminus) and DER1 (via C-terminus) and indirectly with HRD3 (PubMed:20005842, PubMed:19898607, PubMed:21074049, PubMed:32327568). In ERAD-L, HRD3 and YOS9 jointly bind misfolded glycoproteins in the endoplasmic reticulum (ER) lumen (PubMed:32327568). Movement of ERAD-L substrates through the ER membrane is facilitated by HRD1 and DER1 which have lateral gates facing each other and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568). The HRD1 complex interacts with the heterotrimeric CDC48-NPL4-UFD1 ATPase complex which is recruited by UBX2 via its interaction with CDC48 and which moves ubiquitinated substrates to the cytosol for targeting to the proteasome (PubMed:16873066).
messages: Endoplasmic reticulum membrane
messages: Impaired degradation of proteins with misfolded lumenal domains such as CPY*, a mutant, misfolded form of carboxypeptidase Y which is a known ERAD-L substrate. Impaired degradation of proteins with misfolded intramembrane domains. Impaired trans-ubiquitination and degradation of the HRD1 ligase. Degradation of proteins with misfolded cytosolic domains is not affected. Interaction of substrate with HRD1 is reduced; in USA1 and YOS9 double mutants this interaction is completely abolished.
messages: Present with 1890 molecules/cell in log phase SD medium.
messages: Scaffold protein of the endoplasmic reticulum-associated degradation (ERAD) (also known as endoplasmic reticulum quality control, ERQC) pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Has multiple functions in ERAD including recruitment of DER1 to the HRD1 ubiquitin ligase, and regulation of HRD1 activity. Involved in oligomerization of HRD1 and in HRD1 autoubiquitination and degradation.
messages: The ubiquitin-like domain is required for HRD1 trans-ubiquitination and degradation. Reported to be involved in ERAD-M but not ERAD-L function (PubMed:20005842). However, a contradictory report states that it is not required for either ERAD-L or ERAD-M function (PubMed:19940128). Reported to be required for HRD1 oligomer formation (PubMed:19940128). However, a contradictory report does not observe any defects in oligomerization following deletion of the domain (PubMed:21074049).

559292:YPL161C
gene id: 559292:YPL161C
uniprot id: P39011
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell polarity defects; delocalized actin patches and abnormal budding (PubMed:8754840). Cell lysis at high temperature (PubMed:8754840).
messages: Cytoplasm
messages: Interacts with CDC42; the interaction is direct (PubMed:8754839). Interacts with RHO1; the interaction is direct (PubMed:8754839, PubMed:8754840). Interacts with RHO2 (PubMed:8754839). Interacts with RHO4 (PubMed:8754839). Interacts with CDC11 (PubMed:12665577).
messages: Nucleus
messages: Present with 6330 molecules/cell in log phase SD medium.
messages: Probably acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (By similarity). May also chaperone the processing and/or trafficking of small GTPases independently of GEF activity (By similarity). Involved in the control of polarized cell growth via CDC42-mediated signaling (PubMed:8754839). Involved in the control of cell-wall organization via RHO1-mediated signaling (PubMed:8754839, PubMed:8754840). May also function via RHO2 and RHO4 (PubMed:8754839).

559292:YOR217W
gene id: 559292:YOR217W
uniprot id: P38630
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 large subunit family.
messages: Component of the ATP-dependent clamp loader RFC complex for the POL30/PCNA homotrimer DNA clamp. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Replication factor C (RFC or activator 1) complex acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment.
messages: Nucleus
messages: Present with 2360 molecules/cell in log phase SD medium.
messages: Replication factor C (RFC) is a heteropentamer of subunits RFC1, RFC2, RFC3, RFC4 and RFC5 and forms a complex with POL30/PCNA in the presence of ATP. Interacts with ECO1 and POL30/PCNA.

559292:YIR024C
gene id: 559292:YIR024C
uniprot id: P40576
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain.
messages: Component of the inner membrane assembly (INA) complex, composed of INA17 and INA22. Interacts with a subset of F(1)F(0)-ATP synthase subunits of the F(1)-domain and the peripheral stalk.
messages: Mitochondrion inner membrane
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YNR054C
gene id: 559292:YNR054C
uniprot id: P53743
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ESF2/ABP1 family.
messages: Component of the 90S pre-ribosomes. Interacts directly with DBP8.
messages: Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2. Stimulates DBP8 RNA helicase ATPase activity.
messages: Present with 12800 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YBR290W
gene id: 559292:YBR290W
uniprot id: P38356
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BSD2 family.
messages: Endoplasmic reticulum
messages: Increased accumulation of copper, cadmium and cobalt ions and enhanced sensitivity to the toxic effects of copper and cadmium. Exhibits no additional sensitivity to manganese. SMF1 fails to enter the vacuole and is stabilized. Reverses the aerobic defects of yeast strains lacking superoxide dismutase (SOD). Concomitant deletion of SMF1 completely abolishes the ability of BSD2 deletion to suppress SOD deficiency and reverses the increased sensitivity to cadmium and copper. However cobalt ion hyperaccumulation is not suppressed.
messages: Membrane
messages: Present with 3070 molecules/cell in log phase SD medium.
messages: Required for homeostasis of heavy metal ions such as cadmium, cobalt and copper. Controls metal ion transport and prevents metal hyperaccumulation by negatively regulating the SMF1 and SMF2 metal transport systems. Under manganese-replete conditions facilitates trafficking of SMF1 and SMF2 metal transporters to the vacuole where they are degraded.
messages: Vacuole

559292:YPR186C
gene id: 559292:YPR186C
uniprot id: P39933
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's.
messages: Nucleus
messages: Present with 1380 molecules/cell in log phase SD medium.

559292:YEL069C
gene id: 559292:YEL069C
uniprot id: P39924
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Probable glucose transporter.

559292:YGL237C
gene id: 559292:YGL237C
uniprot id: P06774
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP2 has primarily a structural role in the HAP complexes I and II.
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the CCAT-binding factor (CBF or HAP complex II), which consists of one copy each of HAP2, HAP3, HAP4 and HAP5. The assembly of the HAP2-HAP3-HAP5 heteromer (HAP complex I) occurs in a one-step pathway and its binding to DNA is a prerequisite for the association of HAP4.
messages: Nucleus

559292:YKL217W
gene id: 559292:YKL217W
uniprot id: P36035
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Essential to lactate transport.
messages: Membrane

559292:YOR389W
gene id: 559292:YOR389W
uniprot id: Q08912
names: Subcellular Location Annotation
messages: Secreted

559292:YLR419W
gene id: 559292:YLR419W
uniprot id: Q06698
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Probable ATP-binding RNA helicase.

559292:YDL231C
gene id: 559292:YDL231C
uniprot id: Q07660
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE4 family.
messages: Deletion of the gene leads to brefeldin A-sensitivity.
messages: May be involved in intracellular vesicle transport.
messages: Membrane

559292:YBR302C
gene id: 559292:YBR302C
uniprot id: P0CX12
uniprot id: P0CX13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Membrane

559292:YLL013C
gene id: 559292:YLL013C
uniprot id: Q07807
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUF3 family.
messages: Cytoplasm
messages: Mitochondrion outer membrane
messages: Present with 846 molecules/cell in log phase SD medium.
messages: RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology.

559292:YGR154C
gene id: 559292:YGR154C
uniprot id: P48239
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB).
messages: Belongs to the GST superfamily. Omega family.
messages: By diamide and 1-chloro-2,4-dinitrobenzene (CDNB) in a transcriptional factors YAP1 and/or MSN2/4-dependent manner.
messages: Null mutants display increased sensitivity to cadmium in the absence of GTT1 and GTT2. Null mutants also show growth defects on oleic acid-based medium, indicative of abnormal peroxisomal functions and altered expression of genes related to sulfur amino acid metabolism, and have low levels of reduced glutathione.
messages: Peroxisome

559292:YMR126C
gene id: 559292:YMR126C
uniprot id: Q04216
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DLT1 family.
messages: Membrane
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: Required for growth under high-pressure and low-temperature conditions.
messages: Sensitivity to 6-azauracil (6AU) and mycophenolic acid (MPA).

559292:YHR115C
gene id: 559292:YHR115C
uniprot id: P38823
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DMA1 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes (PubMed:18202552). Involved in nutritional control of the cell cycle (PubMed:15319434). Targets the G1 cyclin PCL1 for destruction (PubMed:23264631). Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck (PubMed:15146058).
messages: Interacts with CDC123 (PubMed:15319434). Interacts with PCL1 (PubMed:23264631).
messages: Present with 2790 molecules/cell in log phase SD medium.
messages: Protein levels are regulated by nutrient status, being high under good nutrient conditions.
messages: UBC4-dependent autoubiquitination occurs at Lys-150, Lys-204, Lys-217, Lys-237, Lys-240, Lys-260, Lys-300, Lys-306, Lys-313 and Lys-317. UBC4-dependent autoubiquitination is responsible for DMA2 turnover. UBC13/MMS2-dependent autoubiquitination occurs at Lys-237 and Lys-306. Lys-204 and Lys-306 are also ubiquitinated in trans by DMA2 E3 ligase in association with UBC4.

559292:YJR043C
gene id: 559292:YJR043C
uniprot id: P47110
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.
messages: DNA polymerase delta is a heterotrimer of POL3, POL32 and HYS2. POL32 can form homodimers.
messages: Nucleus
messages: Present with 2410 molecules/cell in log phase SD medium.

559292:YJL185C
gene id: 559292:YJL185C
uniprot id: P46983
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX3, ATG8 and ATG11.
messages: Peroxisome
messages: Required for autophagic breakdown of peroxisomes, called pexophagy, through linking peroxisomes to the autophagy apparatus. Involved in regulation of the glyoxylate cycle.

559292:YPR158W-A
gene id: 559292:YPR158W-A
uniprot id: P0CX59
uniprot id: P0CX60
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-OR is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-PR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YOR360C
gene id: 559292:YOR360C
uniprot id: P06776
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Controls the level of cAMP in yeast cells, together with the low-affinity cAMP phosphodiesterase (PDE1).
messages: Monomer.
messages: Present with 6510 molecules/cell in log phase SD medium.

559292:YDL197C
gene id: 559292:YDL197C
uniprot id: P32448
names: Function
names: Miscellaneous
messages: Derepression of silent mating type loci when overexpressed.
messages: Present with 1910 molecules/cell in log phase SD medium.

559292:YIL112W
gene id: 559292:YIL112W
uniprot id: P40480
names: Function
names: Subunit
messages: Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, CPR1 and SET3.
messages: Unknown. Component of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis.

559292:YAR002W
gene id: 559292:YAR002W
uniprot id: P39705
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. Binds to NUP1 and NUP2 forming the nuclear basket and the distal ring. The interaction with NUP2 is GSP1-GTP-dependent. Interacts through its FG repeats with karyopherins, such as KAP123 and KAP95-SRP1 (KAP60). Also interacts with GSP1-GTP and SRM1 (PRP20), where NUP60 reduces SRM1 activity, thus inhibiting GSP1 guanine nucleotide dissociation.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).
messages: Nucleus membrane
messages: Phosphorylated by CDC28.
messages: Present with 4590 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YMR283C
gene id: 559292:YMR283C
uniprot id: P23796
names: Function
names: Miscellaneous
messages: Present with 259 molecules/cell in log phase SD medium.
messages: tRNA backbone modifying enzyme that mediates initiator/ elongator tRNA discrimination. This enzyme modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. Recognize the stem-loop IV region that is unique in eukaryotic cytoplasmic initiator tRNAs.

559292:YDR179C
gene id: 559292:YDR179C
uniprot id: Q03981
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a COP9 signalosome-like (CSN) complex, composed of at least RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In the complex, it probably interacts directly with CSN12 and CSI1. Interacts also with RPN5.
messages: Component of the COP9 signalosome (CSN) complex that acts as a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.
messages: Cytoplasm
messages: Nucleus
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YCR046C
gene id: 559292:YCR046C
uniprot id: P25626
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:24675956). bL19m is essential for respiration (PubMed:8771712).
messages: Mitochondrion
messages: Present with 4150 molecules/cell in log phase SD medium.

559292:YAR029W
gene id: 559292:YAR029W
uniprot id: P39549
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Cytoplasm
messages: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.
messages: Membrane

559292:YHR161C
gene id: 559292:YHR161C
uniprot id: P38856
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP180 family.
messages: Bud
messages: Bud neck
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with PAN1 and the clathrin heavy and light chains CHC1 and CLC1.
messages: Involved in endocytosis and clathrin cage assembly.
messages: Present with 623 molecules/cell in log phase SD medium.

559292:YOR158W
gene id: 559292:YOR158W
uniprot id: P17558
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 2010 molecules/cell in log phase SD medium.

559292:YDR124W
gene id: 559292:YDR124W
uniprot id: Q04608
names: Miscellaneous
messages: Present with 3510 molecules/cell in log phase SD medium.

559292:YHR213W
gene id: 559292:YHR213W
uniprot id: P0CI66
uniprot id: P0CI67
names: Caution
names: Similarity
messages: Belongs to the flocculin family.
messages: Could be the product of a pseudogene unlikely to encode a functional protein. This is a truncated version of a flocculin protein family member. Because of that it is not part of the S.cerevisiae S288c complete/reference proteome set.

559292:YGR209C
gene id: 559292:YGR209C
uniprot id: P22803
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Monomer. Part of the heterodimeric LMA1 complex together with the proteinase inhibitor PBI2. LMA1 binds to the ATPase SEC18.
messages: Nucleus
messages: Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl-hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress.
messages: Present with 17237 molecules/cell in log phase SD medium.
messages: Reversible disulfide bond formation between Cys-31 and Cys-34, reverted by thioredoxin reductase TRR1 using NADPH as hydrogen donor.
messages: Strongly induced by hydrogen peroxide and diamide stress in a YAP1- and SKN7-dependent manner. Also induced by reducing stress by DTT.
messages: Yeast has two cytoplasmic thioredoxins, TRX1 and TRX2, and one mitochondrial, TRX3.

559292:YHR076W
gene id: 559292:YHR076W
uniprot id: P38797
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Binds 2 magnesium or manganese ions per subunit.
messages: By the presence of non-fermentable carbon sources and oxidative stress.
messages: Decreased growth in non-fermentable sugar mediums (PubMed:23940037, PubMed:28076776). This is caused by a decrease in COQ6 levels, which results in a severe decrease in complex II, NADH-coenzyme Q dehydrogenase to complex III, and complex II to complex III activities in the electron transport chain (PubMed:23940037). Impaired antioxidant defenses (PubMed:23940037). Decreased phosphorylation of CAT5/COQ7 (PubMed:23940037). Increased phosphorylation of CIT1 and decreased citrate synthase activity (PubMed:28076776).
messages: Mitochondrion
messages: Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:12220683, PubMed:23940037, PubMed:28076776, PubMed:30267671). Dephosphorylates and activates the ubiquinone biosynthesis protein CAT5/COQ7 (PubMed:23940037, PubMed:30267671). Also dephosphorylates CIT1 on 'Ser-462', which leads to its activation (PubMed:28076776).
messages: There are conflicting reports on the effect the deletion of PTC7 causes in cells (PubMed:23940037, PubMed:28076776). In one report, deletion of PTC7 causes decreases in COQ6 levels, and mitochondrial defects observed are thought to be caused by disruption of the COQ6 pathway (PubMed:23940037). In another report, deletion of PTC7 causes no change in COQ6 levels and mitochondrial defects observed in mutants are not thought to be caused by changes in the COQ6 pathway (PubMed:28076776).

559292:YDR101C
gene id: 559292:YDR101C
uniprot id: Q03862
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family.
messages: Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles. Interacts directly with REI1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 45100 molecules/cell in log phase SD medium.
messages: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.

559292:YNR034W
gene id: 559292:YNR034W
uniprot id: P50278
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Cytoplasm
messages: Lacks 6-phosphogluconolactonase activity.
messages: May be involved in regulation of tRNA subcellular distribution.
messages: Nucleus
messages: Present with 1970 molecules/cell in log phase SD medium.

559292:YDR349C
gene id: 559292:YDR349C
uniprot id: Q06325
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YLR450W
gene id: 559292:YLR450W
uniprot id: P12684
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway constitutes by the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:3065625, PubMed:3526336). HMG1 and HMG2 catalyze the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate that is the rate-limiting step within the first mosule (PubMed:3526336). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672).
messages: Nucleus envelope
messages: Present with 149 molecules/cell in log phase SD medium.
messages: The sterol-sensing domain (SSD) is required for sterol pathway signals to stimulate hmg2 ER-associated degradation and detects both geranylgeranyl pyrophosphate and a secondary oxysterol signal.
messages: When both HMG1 and HMG2 are deleted, cells are unable to undergo spore germination and vegetative growth.

559292:YEL038W
gene id: 559292:YEL038W
uniprot id: P32626
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Present with 2850 molecules/cell in log phase SD medium.

559292:YOR117W
gene id: 559292:YOR117W
uniprot id: P33297
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: N-acetylated by NAT1.
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

559292:YLR364W
gene id: 559292:YLR364W
uniprot id: Q05926
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutaredoxin family.
messages: Cytoplasm
messages: Glutathione-dependent oxidoreductase with lower activity compared to the other members of the glutaredoxin family. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.
messages: Monomer.
messages: Present with 573 molecules/cell in log phase SD medium.
messages: Strongly induced by the exposure to arsenic which causes glutathione depletion.

559292:YPR137W
gene id: 559292:YPR137W
uniprot id: Q06506
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RRP9 family.
messages: Interacts with UTP25. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for efficient pre-rRNA cleavage at sites A0, A1 and A2, and biosynthesis of 18S rRNA.
messages: Present with 5130 molecules/cell in log phase SD medium.
messages: The WD domains are required for nucleolar localization and U3 small nucleolar RNAs binding.
messages: nucleolus

559292:YDL022W
gene id: 559292:YDL022W
uniprot id: Q00055
names: Caution
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: By osmotic stress and by methylglyoxal in a HOG pathway-dependent manner.
messages: Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells.
messages: Cytoplasm
messages: Peroxisome
messages: Present with 807 molecules/cell in log phase SD medium.
messages: Was originally thought to be GUT2, the FAD-dependent glycerol-3-phosphate dehydrogenase.

559292:YPL120W
gene id: 559292:YPL120W
uniprot id: Q02948
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beclin family.
messages: Component of the autophagy-specific VPS34 PI3-kinase complex I composed of VPS15, VPS30, VPS34, ATG14 and ATG38; and of the VPS34 PI3-kinase complex II composed of VPS15, VPS30, VPS34 and VPS38.
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: Present with 2490 molecules/cell in log phase SD medium.
messages: Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Also plays a role in regulation of filamentous growth.
messages: The C-terminal domain called the BARA domain is dispensable for the construction of both VPS34 PI3-kinase complexes, but is specifically required for autophagy through the targeting of complex I to the pre-autophagosomal structure.
messages: Vacuole membrane

559292:YKL075C
gene id: 559292:YKL075C
uniprot id: P36083
names: Miscellaneous
messages: Present with 98 molecules/cell in log phase SD medium.

559292:YNL339C
gene id: 559292:YNL339C
uniprot id: P53819
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YGL202W
gene id: 559292:YGL202W
uniprot id: P53090
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Responsible for phenylalanine and tyrosine biosynthesis. Active with glutamate, phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate, 2-oxoglutarate and pyruvate as amino acceptors. Also active with methionine, alpha-aminoadipate and leucine as amino donors when phenylpyruvate is the amino acceptor and in the reverse reactions with the corresponding oxo acids and phenylalanine as amino donor. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the formation of alpha-aminoadipate from alpha-ketoadipate in the lysine biosyntheic pathway.
messages: Present with 1770 molecules/cell in log phase SD medium.

559292:YHR006W
gene id: 559292:YHR006W
uniprot id: P38704
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the amino acid-induced proteolytic removal of an N-terminal inhibitory domain by serine protease SSY5, an intrinsic component of the SPS-sensor. Processing requires at least 2 components of the SCF(GRR1) ubiquitin ligase complex, namely the F-box protein GRR1 and the E2 enzyme CDC34, but does not depend on the proteasome. Processing is negatively regulated by the protein phosphatase 2A regulatory subunit RTS1 (By similarity).
messages: Cell membrane
messages: Interacts (via Region II) with SSY5; protease component of the SPS-sensor.
messages: Nucleus
messages: Present with 6490 molecules/cell in log phase SD medium.
messages: The N-terminal inhibitory domain contains conserved sequence elements important for cytoplasmic retention (Region I) and proteolytic processing (Region II) of the protein (By similarity). Region I is also required for ASI1/2/3-mediated negative regulation of transcription.
messages: Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases BAP2 and BAP3. Binding to promoters is facilitated by DAL81 (By similarity). Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes.

559292:YGL167C
gene id: 559292:YGL167C
uniprot id: P13586
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Golgi apparatus membrane
messages: Present with 6900 molecules/cell in log phase SD medium.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway.

559292:YPR094W
gene id: 559292:YPR094W
uniprot id: Q06835
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PHF5 family.
messages: Component of the spliceosome where it interacts with CUS1, HSH49, HSH155, IST3 and RSE1. Also interacts with YRA1.
messages: Nucleus
messages: Required for pre-mRNA splicing. Involved in regulation of drug sensitivity and may play a role in multidrug resistance.

559292:YOL040C
gene id: 559292:YOL040C
uniprot id: Q01855
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS19 is involved in the nuclear export of the small ribosomal subunit precursor. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm (PubMed:15167894).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm

559292:YGL056C
gene id: 559292:YGL056C
uniprot id: P53172
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation during budding.
messages: Nucleus
messages: Present with 21200 molecules/cell in log phase SD medium.

559292:YDL144C
gene id: 559292:YDL144C
uniprot id: Q07589
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 5171 molecules/cell in log phase SD medium.

559292:YGR296W
gene id: 559292:YGR296W
uniprot id: P0CX14
uniprot id: P0CX15
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YJL225C
gene id: 559292:YJL225C
uniprot id: P40889
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YNL007C
gene id: 559292:YNL007C
uniprot id: P25294
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with polyadenylate-binding protein PAB1.
messages: Nucleus
messages: Present with 20300 molecules/cell in log phase SD medium.
messages: Required for nuclear migration during mitosis. It is required for the normal initiation of translation. Might mediate the dissociation of a specific protein complex of the translation machinery. Essential for viability.

559292:YBR067C
gene id: 559292:YBR067C
uniprot id: P27654
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Extensively O-glycosylated.
messages: Induced during anaerobic growth and by cold shock and heat shock.
messages: Membrane
messages: Present with 35600 molecules/cell in log phase SD medium.
messages: Seems to have esterase activity. Prefers ester of fatty acids from 4 to 16 carbon atoms.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YDR462W
gene id: 559292:YDR462W
uniprot id: P36527
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 6300 molecules/cell in log phase SD medium.

559292:YNL196C
gene id: 559292:YNL196C
uniprot id: P40167
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation on some mRNAs during meiosis and is required for sporulation. In the complex, mediates the entry of the MIS complex in nucleolus, where methylation takes place.
messages: Component of the MIS complex, composed of SLZ1, MUM2 and IME4.
messages: Cytoplasm
messages: During sporulation. Expression is activated by IME1 during meiosis.
messages: Impairs sporulation.
messages: nucleolus

559292:YDR527W
gene id: 559292:YDR527W
uniprot id: Q04418
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP1 family.
messages: Cytoplasm
messages: Down-regulated at low calcium levels.
messages: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.
messages: Present with 688 molecules/cell in log phase SD medium.

559292:YGR146C
gene id: 559292:YGR146C
uniprot id: P48235
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the ecl1 family.
messages: Expression is induced by the AFT2 iron homeostasis transcription factor, as well as by 8-methoxypsoralen and UVA radiation.
messages: Involved in chronological cell aging.
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YGL048C
gene id: 559292:YGL048C
uniprot id: Q01939
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: May form a homodimer or a heterodimer with a related family member. Interacts with OLA1, TMA17, and UBR1.
messages: N-acetylated by NAT1.
messages: Nucleus
messages: Present with 4700 molecules/cell in log phase SD medium.
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

559292:YLR143W
gene id: 559292:YLR143W
uniprot id: Q12429
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EFT1 or EFT2) to diphthamide.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the RutC family.
messages: In the N-terminal section; belongs to the Diphthine--ammonia ligase family.
messages: Interacts with elongation factor 2 (eEF-2; EFT1 or EFT2).
messages: Present with 2270 molecules/cell in log phase SD medium.
messages: Resistance to sordarin.

559292:YFL034C-B
gene id: 559292:YFL034C-B
uniprot id: P43563
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOB1/phocein family.
messages: Cytoplasm
messages: Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation.
messages: Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex.
messages: Nucleus
messages: Present with 2250 molecules/cell in log phase SD medium.

559292:YDR333C
gene id: 559292:YDR333C
uniprot id: Q05468
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCF25 family.
messages: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123). RQC1 is essential for the recruitment of CDC48 to ribosomal subunits (PubMed:23479637).
messages: Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase RKR1/LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits (PubMed:23178123, PubMed:23479637).
messages: Cytoplasm
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YNL135C
gene id: 559292:YNL135C
uniprot id: P20081
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Binds to the immunosuppressant drug FK506 and also mediates the sensitivity to rapamycin (PubMed:1996117). Rapamycin disrupts interaction with FAP1.
messages: Cytoplasm
messages: Interacts with HMO1. Interacts with FAP1.
messages: Mitochondrion
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Present with 43300 molecules/cell in log phase SD medium.

559292:YLR108C
gene id: 559292:YLR108C
uniprot id: Q12259
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 189 molecules/cell in log phase SD medium.

559292:YDL010W
gene id: 559292:YDL010W
uniprot id: Q12438
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutaredoxin family. Monothiol subfamily.
messages: Present with 1643 molecules/cell in log phase SD medium.
messages: Vacuole

559292:YDR139C
gene id: 559292:YDR139C
uniprot id: Q03919
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts with CDC53 and DCN1.
messages: Present with 1310 molecules/cell in log phase SD medium.
messages: Ubiquitin-like protein modifier that can be covalently attached to lysine residues of target proteins. Activated by the dimeric UBA3-ULA1 E1 enzyme and conjugated by the E2 UBC12 to substrate proteins. RUB1-conjugated (neddylated) substrate proteins include the cullins CDC53, RTT101 and CUL3, and the modification enhances the ubiquitin-ligase activity of the corresponding cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs).

559292:YKL210W
gene id: 559292:YKL210W
uniprot id: P22515
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:18662542, PubMed:1989885, PubMed:24816100). The RSP5-UBA1-UBC5 ubiquitin ligase complex ubiquitinates RPO21 forming 'Lys-63'-linked polyubiquitin chains (PubMed:19920177).
messages: Cytoplasm
messages: Monomer. Binds simultaneously two ubiquitin chains (PubMed:24816100). Component of the RSP5-UBA1-UBC5 ubiquitin ligase complex composed of E3 RSP5, E1 UBA1 and E2 UBC5 (Probable).
messages: Nucleus
messages: Present with 17700 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.
messages: There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.

559292:YOR327C
gene id: 559292:YOR327C
uniprot id: P33328
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endomembrane system
messages: Palmitoylated by SWF1.
messages: Present with 300 molecules/cell in log phase SD medium.
messages: SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion.

559292:YHR153C
gene id: 559292:YHR153C
uniprot id: P17122
names: Function
messages: Necessary for efficient spore formation.

559292:YLR157W-D
gene id: 559292:YLR157W-D
uniprot id: P0CE99
names: Miscellaneous
messages: There are 3 tandem-duplicated genes coding for this protein in S.cerevisiae (YLR156W, YLR159W and YLR161W). Additionally, a fourth copy has been disrupted by a Ty1 retrotransposon, which led to the prediction of the 2 dubious ORFs YLR157W-D and YLR157W-E.

559292:YPL011C
gene id: 559292:YPL011C
uniprot id: Q12297
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF3 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus
messages: Present with 3300 molecules/cell in log phase SD medium.
messages: TAF3 heterodimerizes with TAF10. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.

559292:YKL016C
gene id: 559292:YKL016C
uniprot id: P30902
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase d subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 6820 molecules/cell in log phase SD medium.

559292:YMR047C
gene id: 559292:YMR047C
uniprot id: Q02630
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin GLFG family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport (PubMed:10891509). NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof (PubMed:10891509). NUP116 interacts with the NUP82 subcomplex and GLE2 (PubMed:10801828, PubMed:9463388, PubMed:10891509). Through its FG repeats it interacts with numerous karyopherins including KAP95, PSE1 (GSP1-GDP dependent), MEX67, and to homomeric RNA (PubMed:9891088, PubMed:10952996, PubMed:11104765, PubMed:12372823). Interacts with CEX1 (PubMed:17203074). Interacts (via N-terminus) with AFG2 (via N-terminus) (PubMed:23185031).
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). Plays an important role in several nuclear export and import pathways including poly(A)+ RNA, tRNA, pre-ribosome, and protein transport. By binding ATPase AFG2, promotes AFG2-mediated release of shuttling protein RLP24 from pre-60S ribosomal particles (PubMed:23185031).
messages: Nucleus membrane
messages: nuclear pore complex

559292:YDR365W-B
gene id: 559292:YDR365W-B
uniprot id: P0C2I3
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YDR365W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YLR046C
gene id: 559292:YLR046C
uniprot id: Q12253
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.
messages: Membrane

559292:YGR262C
gene id: 559292:YGR262C
uniprot id: P53323
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. Important for bud site selection.
messages: Cytoplasm
messages: Nucleus
messages: Present with 3020 molecules/cell in log phase SD medium.
messages: This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (PubMed:12023889). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase (By similarity).
messages: telomere

559292:YPR158C-C
gene id: 559292:YPR158C-C
uniprot id: Q6Q5H1
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-PR3 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YBR043C
gene id: 559292:YBR043C
uniprot id: P38227
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: Cell membrane
messages: Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate).
messages: Present with 279 molecules/cell in log phase SD medium.

559292:YNL094W
gene id: 559292:YNL094W
uniprot id: P53933
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Contains one Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
messages: Inhibited by N-ethylmaleimide.
messages: Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. May play a role in vesicular trafficking through its PAP activity at cortical actin patches (PubMed:23071111, PubMed:23335564). Can also utilize diacylglycerol pyrophosphate and lyso-PA as substrates with specificity constants 4- and 7-fold lower, respectively, when compared with PA (PubMed:23335564).
messages: Monomer (PubMed:23335564). Interacts with ABP1 (PubMed:14737190).
messages: N-glycosylated.
messages: Present with 2289 molecules/cell in log phase SD medium.
messages: actin patch

559292:YGR055W
gene id: 559292:YGR055W
uniprot id: P50276
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: High affinity permease for methionine.
messages: Membrane
messages: To yeast low affinity methionine permease (MUP3).

559292:YMR279C
gene id: 559292:YMR279C
uniprot id: Q03263
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

559292:YMR006C
gene id: 559292:YMR006C
uniprot id: Q03674
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysophospholipase family.
messages: Membrane
messages: Present with 623 molecules/cell in log phase SD medium.
messages: Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. However, it does not display transacylase activity. Substrate preference is phosphatidylserine > phosphatidylinositol > phosphatidylcholine > phosphatidylethanolamine (PubMed:10231538, PubMed:10497163). The substrate specificity is pH- and ion-dependent. In contrast with activities observed at optimum pH 3.5, the order of substrate preference at pH 5.5 is phosphatidylserine = phosphatidylethanolamine > phosphatidylcholine > phosphatidylinositol (PubMed:15588231).
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YGL260W
gene id: 559292:YGL260W
uniprot id: P53056
names: Similarity
messages: Belongs to the UPF0377 family.

559292:YBR281C
gene id: 559292:YBR281C
uniprot id: P38149
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Component of the GSH degradosomal complex composed of at least DUG1, DUG2 and DUG3.
messages: Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1940 molecules/cell in log phase SD medium.

559292:YIL066C
gene id: 559292:YIL066C
uniprot id: P21672
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Cytoplasm
messages: Heterotetramer of two large (R1) and two small (R2) subunits. S.cerevisiae has two different R1 subunits (RNR1 and RNR3) and two different R2 subunits (RNR2 and RNR4). The functional form of the small subunits is a RNR2-RNR4 heterodimer, where RNR2 provides the iron-radical center and RNR4 is required for proper folding of RNR2 and assembly with the large subunits. Under normal growth conditions, the active form of the large subunits is a homodimer of the constitutively expressed RNR1. In damaged cells or cells arrested for DNA synthesis, the reductase consists of multiple species because of the association of the small subunits (RNR2-RNR4) with either the RNR1 homodimer or a heterodimer of RNR1 and the damage-inducible RNR3.
messages: Highly induced by DNA-damage.
messages: Present with 1364 molecules/cell in log phase SD medium.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on R1, is formed only in the presence of the second subunit R2 (By similarity).
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the large subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site (By similarity).

559292:YPL012W
gene id: 559292:YPL012W
uniprot id: Q12754
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP12 family.
messages: Cytoplasm
messages: In association with GSP1, required for nuclear export of both pre-40S and pre-60S ribosomal subunits. Required for the late maturation of the 18S and 5.8S rRNA of the pre-40S ribosomes and for maturation of the 25S and 5.8S rRNA of the pre-60S ribosomes.
messages: Interacts with GSP1.
messages: Present with 8170 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YOL100W
gene id: 559292:YOL100W
uniprot id: Q12236
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
messages: Long-term depletion of PKH2 in a PKH1 null mutant (Pkh depletion) induces programmed cell death. This is mediated by the lack of Pkh-dependent activation of the PKC1 downstream signaling cascade and results in accumulation of reactive oxigen species (ROS) and DNA fragmentation.
messages: Nucleus
messages: Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step.
messages: Sphingoid base activates kinase activity.
messages: The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
messages: cell cortex

559292:YLR435W
gene id: 559292:YLR435W
uniprot id: Q06672
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TSR2 family.
messages: Cytoplasm
messages: Interacts with RPS26A.
messages: Nucleus
messages: Present with 13400 molecules/cell in log phase SD medium.
messages: Required for 20S pre-rRNA processing.

559292:YHR013C
gene id: 559292:YHR013C
uniprot id: P07347
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ARD1 subfamily.
messages: Catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.
messages: Component of the N-terminal acetyltransferase A (NatA) complex, which is composed of ARD1, NAT1 and NAT5. Can self-associate.
messages: Cytoplasm
messages: Present with 3310 molecules/cell in log phase SD medium.

559292:YHR194W
gene id: 559292:YHR194W
uniprot id: P38880
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM31/MDM32 family.
messages: Interacts with MDM32. Participates in a complex of about 600 kDa.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
messages: Mitochondrion inner membrane
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YMR297W
gene id: 559292:YMR297W
uniprot id: P00729
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S10 family.
messages: Enters the endoplasmic reticulum as an inactive zymogen and is modified by four N-linked core oligosaccharides, giving rise to a precursor known as P1 (67 kDa). As P1 transits through the Golgi, extension of its core oligosaccharides leads to the Golgi-modified P2 precursor (69 kDa). P2 is sorted away from secretory proteins at or beyond a late Golgi compartment and is subsequently delivered to the vacuole via a prevacuolar endosome-like compartment. Upon arrival in the vacuole, the N-terminal prosegment of P2 is cleaved by vacuolar proteases to yield the enzymatically active mature vacuolar form of CPY (61 kDa).
messages: Inhibited by ZPCK.
messages: Leads to vacuolar defects as well as defects in the terminal steps of autophagy, when ATG42 is also deleted (PubMed:29514932). The PCR1/ATG42 double deletion abrogates also the production of phytochelatin and the degradation of glutathione-S-conjugates (PubMed:17408619, PubMed:19897216).
messages: Present with 44000 molecules/cell in log phase SD medium.
messages: The four high mannose core N-glycans found in mature CPY are Man(11-15)GlcNAc(2) at Asn-124, Man(8-12)GlcNAc(2) at Asn-198, Man(9-14)GlcNAc(2) at Asn-279 and phosphorylated Man(12-17)GlcNAc(2) as well as Man(11-16)GlcNAc(2) at Asn-479.
messages: Vacuolar serine-type carboxypeptidase involved in degradation of small peptides (PubMed:8679540). Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (PubMed:8679540). Also plays a role in breakdown of the autophagic body and the autophagosome-dependent protein synthesis (PubMed:29514932). Plays a key role in phytochelatin (PC) synthesis from glutathione (GSH) by cleaving the Gly from GSH and form the PC-peptides of the structure (gamma-Glu-Cys)2-Gly (PubMed:17408619). Also involved in resistance to xenobiotics via the degradation of glutathione-S-conjugates (PubMed:19897216).
messages: Vacuole lumen

559292:YPR016C
gene id: 559292:YPR016C
uniprot id: Q12522
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: Present with 18600 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YJR127C
gene id: 559292:YJR127C
uniprot id: P46974
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSF2/TDA9 family.
messages: Nucleus
messages: Transcription factor that regulates expression of both nuclear and mitochondrial genes, and more specifically those required for glycerol-based growth and respiration.

559292:YBL033C
gene id: 559292:YBL033C
uniprot id: P38066
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Present with 9520 molecules/cell in log phase SD medium.

559292:YKL081W
gene id: 559292:YKL081W
uniprot id: P36008
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Present with 102130 molecules/cell in log phase SD medium.
messages: Subunit of the eukaryotic elongation factor 1 complex (eEF1). Probably plays a role in anchoring the complex to other cellular components (By similarity).
messages: The eukaryotic elongation factor 1 complex (eEF1) is probably a heterohexamer. Two trimeric complexes, each composed of eEF1A (TEF1 or TEF2), eEF1Balpha (EFB1) and eEF1Bgamma (CAM1 or TEF4), are probably dimerized via the eF1Bgamma subunits. The eEF1B subcomplex with the GEF activity is formed of eEF1Balpha and eEF1Bgamma. TEF4 interacts with EFB1 (By similarity).

559292:YDR019C
gene id: 559292:YDR019C
uniprot id: P48015
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Component of the glycine decarboxylase complex (GDC), which is composed of four proteins: P, T, L and H.
messages: Mitochondrion
messages: Present with 4090 molecules/cell in log phase SD medium.
messages: The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine.

559292:YOL103W
gene id: 559292:YOL103W
uniprot id: P30606
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Minor transporter for myo-inositol.
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YFL039C
gene id: 559292:YFL039C
uniprot id: P60010
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (Probable). Treatments with Lantrunculin A, the microbial peptide Chondramide or the microbial metabolite Chivazole F inhibit actin polymerization (PubMed:28796488). Each actin can bind to 4 others. Interacts with YIH1 (via C-terminus); this interaction occurs in a GCN1-independent manner (PubMed:15126500, PubMed:21239490). Component of the INO80 complex. Component of the SWR1 complex. Component of the NuA4 complex.
messages: cytoskeleton

559292:YHR106W
gene id: 559292:YHR106W
uniprot id: P38816
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts on mitochondrial thioredoxin 3. Implicated in the defense against oxidative stress.
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YGL100W
gene id: 559292:YGL100W
uniprot id: P53011
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. SEH1 is part of the heptameric 0.5 MDa autoassembling NUP84 NPC subcomplex (NUP84, NUP85, NUP120, NUP133, NUP145C, SEC13 and SEH1). Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Involved in nuclear poly(A)+ RNA export and NPC biogenesis. It is also required for normal nuclear morphology. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.
messages: Nucleus membrane
messages: Present with 952 molecules/cell in log phase SD medium.
messages: Vacuole membrane
messages: nuclear pore complex

559292:YBR280C
gene id: 559292:YBR280C
uniprot id: P38352
names: Function
names: Subunit
messages: Interacts with AAH1, SKP1 and CDC53. Component of the SCF(SAF1) complex containing CDC53, SKP1, HRT1 and SAF1.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Targets AAH1 adenine deaminase for proteasome-dependent degradation upon entry into quiescence. Targets also URA7.

559292:YDR087C
gene id: 559292:YDR087C
uniprot id: P35178
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP1 family.
messages: Present with 6960 molecules/cell in log phase SD medium.
messages: Required for 27S rRNA processing to 25S and 5.8S.
messages: nucleolus

559292:YDR217C
gene id: 559292:YDR217C
uniprot id: P14737
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Essential for cell cycle arrest at the G2 stage following DNA damage by X-irradiation or inactivation of DNA ligase.
messages: Nucleus
messages: Physically associates with RAD53.
messages: Present with 400 molecules/cell in log phase SD medium.

559292:YBL018C
gene id: 559292:YBL018C
uniprot id: P38208
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.
messages: Nucleus
messages: Present with 4870 molecules/cell in log phase SD medium.

559292:YCR069W
gene id: 559292:YCR069W
uniprot id: P25334
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

559292:YPR089W
gene id: 559292:YPR089W
uniprot id: O13585
names: Miscellaneous
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: Present with 3690 molecules/cell in log phase SD medium.

559292:YMR010W
gene id: 559292:YMR010W
uniprot id: Q03687
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Phospholipid scramblase that transports phosphatidylserine (PS) and phosphatidylethalonamine (PE) bidirectionally from one leaflet to the other of the phospholipid bilayer to at least partially collapse the membrane asymmetry established by NEO1 and other flippases (PubMed:27811238, PubMed:28057802). Functions in the trafficking pathway from endosomes to the trans-Golgi network (TGN) (PubMed:28057802).
messages: Present with 937 molecules/cell in log phase SD medium.
messages: Suppresses the growth defects caused by mutations of flippases including NEO1, DRS2, DNF1, DNF2 and DNF3, as well as of the DRS2 regulator CDC50.

559292:YNL041C
gene id: 559292:YNL041C
uniprot id: P53959
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.
messages: Golgi apparatus membrane
messages: Present with 1720 molecules/cell in log phase SD medium.

559292:YDR098C-B
gene id: 559292:YDR098C-B
uniprot id: Q03855
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YDR098C-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YER143W
gene id: 559292:YER143W
uniprot id: P40087
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartic protease (PubMed:21266539). Appears to act as negative regulator of constitutive exocytosis (PubMed:10330187, PubMed:12051757). May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly (PubMed:12925750). Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation (PubMed:17144915, PubMed:16478980). Required for S-phase checkpoint control (PubMed:11238935, PubMed:17144915).
messages: Belongs to the DDI1 family.
messages: By DNA damage via PDR3.
messages: Cell membrane
messages: Cytoplasm
messages: Forms homodimers. Interacts with RAD23. These interactions are mediated by the UBA domain. Is also able to bind ubiquitin and polyubiquitinated proteins. Interacts with the SNAREs SNC1, SNC2, SSO1, TLG1 and TLG2. Binding to SSO1 is promoted by the phosphorylation of 'Ser-49' of SSO1 by TKP1.
messages: Inhibited by the proteinase inhibitors indinavir, lopinavir, nelfinavir, isovaleryl pepstatin, ritonavir, saquinavir and tipranavir.
messages: Present with 6510 molecules/cell in log phase SD medium.

559292:YBR096W
gene id: 559292:YBR096W
uniprot id: P38256
names: Miscellaneous
names: Similarity
messages: Belongs to the lcsJ thioesterase family.
messages: Present with 1950 molecules/cell in log phase SD medium.

559292:YGR141W
gene id: 559292:YGR141W
uniprot id: P53285
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS62 family.
messages: Involved in vacuolar protein sorting.
messages: Membrane
messages: Present with 623 molecules/cell in log phase SD medium.

559292:YDR168W
gene id: 559292:YDR168W
uniprot id: P06101
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC37 family.
messages: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Involved in both the HOG and the PKC MAP kinase signaling cascade necessary for adaptation to stress conditions due to high osmolarity or cell wall perturbation.
messages: Cytoplasm
messages: Forms a complex with Hsp90. Interacts with CDC28, CAK1 HOG1, SLT2 and STE11.
messages: Phosphorylation at Ser-14 is required for the interactions with HOG1 and SLT2 MAP kinases and is crucial for adaptation to stress conditions due to high osmolarity or cell wall perturbation.
messages: Present with 10200 molecules/cell in log phase SD medium.

559292:YJR151C
gene id: 559292:YJR151C
uniprot id: P47179
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Cell membrane
messages: Component of the cell wall.
messages: Extensively O-glycosylated.
messages: Induced during anaerobic growth and completely repressed during aerobic growth.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
messages: cell wall

559292:YDR130C
gene id: 559292:YDR130C
uniprot id: Q03898
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms cell-cycle specific filaments between the spindle pole bodies of dividing yeast cells.
messages: Homooligomer; in vitro, FIN1 self-assembles into 10 nm diameter filaments. Interacts with the 14-3-3 proteins BMH1 and BMH2, and the protein phosphatase 1 complex catalytic subunit GLC7.
messages: Induced during G2-M transition.
messages: Nucleus
messages: Overexpression is lethal in haploids and causes very poor growth in diploids.
messages: Phosphorylated by CDC28. Phosphorylation is required for BMH1 and BMH2 interaction. Dephosphorylation by GLC7 depends on the presence of BMH1 and BMH2.
messages: Strong overexpression results in the accumulation of filamentous structures resembling the neurofibrillary tangles found in cells of patients with Alzheimer disease.
messages: The coiled coil domain is essential for dimerization.
messages: cytoskeleton
messages: spindle pole

559292:YGL094C
gene id: 559292:YGL094C
uniprot id: P53010
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Cytoplasm
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Positively regulated by the regulatory subunit PAN3. Negatively regulated by PAB1-binding protein PBP1. Inhibited under stress conditions. Inhibition of deadenylation under stress increases mRNA stability, which may be a mechanism to retain the majority of the cytoplasmic pool of mRNAs for later reuse and recovery from stress.
messages: Present with 1510 molecules/cell in log phase SD medium.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

559292:YKR022C
gene id: 559292:YKR022C
uniprot id: P36118
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NTR complex (NTC-related complex), composed of NTR1, NTR2 and PRP43. Interacts with CLF1, NTR1 and PRP43.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.
messages: Nucleus
messages: Present with 892 molecules/cell in log phase SD medium.

559292:YKL002W
gene id: 559292:YKL002W
uniprot id: P36108
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Core component of the ESCRT-III complex (endosomal sorting required for transport complex III). ESCRT-III appears to be sequentially assembled as a flat lattice on the endosome membrane and forms a transient 450 kDa complex that contains DID4, oligomerized SNF7, VPS20 and VPS24. SNF7 oligomerization into a membrane-associated filament is nucleated by association of SNF7 with VPS20; the process is terminated through association of VPS24, possibly by capping the SNF7 filament. VPS24 subsequently associates with DID4/VPS2.
messages: Cytoplasm
messages: Endosome membrane
messages: Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Can directly stimulate VPS4 ATPase activity. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III.

559292:YNL239W
gene id: 559292:YNL239W
uniprot id: Q01532
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.
messages: Inhibited by E64, a specific inhibitor of cysteine proteases, N-ethylmaleimide, iodacetamide, and mercury and zinc ions.
messages: Mitochondrion
messages: Present with 521 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-30 of isoform Mitochondrial.
messages: The N-terminus of isoform Cytoplasmic is blocked.
messages: The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.

559292:YOR301W
gene id: 559292:YOR301W
uniprot id: Q08760
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Bud tip
messages: Cell membrane
messages: Interacts with BUD8, BUD9 and RAX2.
messages: Required for the establishment of the bipolar budding pattern. Involved in selecting bud sites at both the distal and proximal poles of daughter cells as well as near previously used division sites on mother cells. Has a role in the localization of BUD8, the distal bipolar budding landmark, and of BUD9, the proximal pole landmark.

559292:YDR174W
gene id: 559292:YDR174W
uniprot id: Q03973
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.
messages: Interacts with FPR1. Interacts with an unidentified DNA helicase. Associates with rDNA.
messages: Present with 19000 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YNR032W
gene id: 559292:YNR032W
uniprot id: P32838
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2A subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Inactivated in a complex with phosphatase methylesterase PPE1 (PP2Ai). Interacts with phosphatase 2A activator RRD1, which can reactivate PP2Ai by dissociating the catalytic subunit from the complex. Interacts with TAP42.
messages: Involved in glycogen accumulation.
messages: Present with 1960 molecules/cell in log phase SD medium.
messages: Reversibly methyl esterified on Leu-368 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.

559292:YJR122W
gene id: 559292:YJR122W
uniprot id: P47158
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family. CAF17 subfamily.
messages: Interacts with CCR4, ISA1 and ISA2.
messages: Mitochondrion matrix
messages: Present with 2960 molecules/cell in log phase SD medium.
messages: Required for lysine and glutamate prototrophy and mitochondrial genome maintenance. Has a role in the maturation of mitochondrial aconitase-type and radical-SAM Fe/S proteins biotin synthase and lipoic acid synthase.
messages: Up-regulated during calcium shortage.

559292:YHL043W
gene id: 559292:YHL043W
uniprot id: P38728
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: May be involved in cell wall organization and biogenesis.
messages: Membrane

559292:YHR089C
gene id: 559292:YHR089C
uniprot id: P28007
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) (PubMed:9556561, PubMed:9843512, PubMed:21131909). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10 (PubMed:9556561, PubMed:9843512, PubMed:21131909). The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind. Interacts with snoRNAs (PubMed:9556561, PubMed:9843512).
messages: Methylated by HMT1, forming asymmetric dimethylarginines (DMA) within a domain referred to as an RGG box, made up of repeated Gly-Gly dipeptides interspersed with Arg and aromatic residues.
messages: Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9303321, PubMed:9843512). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9303321, PubMed:9843512). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9303321).
messages: Present with 5730 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YGR015C
gene id: 559292:YGR015C
uniprot id: P53208
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alcohol acetyltransferase that catalyzes the synthesis of ethyl acetate from ethanol and acetyl-CoA (PubMed:28356220). Can also function as a thioesterase by hydrolyzing acetyl-CoA in the absence of ethanol, as well as esterase hydrolyzing ethyl acetate (By similarity).
messages: Belongs to the AB hydrolase superfamily.
messages: Mitochondrion
messages: Reduces ethyl acetate production by at least 50%.
messages: S.cerevisiae produces only trace amounts of ethyl acetate. These traces help S.cerevisiae disseminate in the environment by attracting fruit flies. However, as ethyl acetate is a key flavor compound and the most abundant ester in wine and beer, ethyl acetate-producting genes such as ethanol acetyltransferase are relevant for the fermented foods and beverages industry.

559292:YPL008W
gene id: 559292:YPL008W
uniprot id: P22516
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (PubMed:10931920). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (PubMed:15020404, PubMed:14742714). Has a specific role in chromosome segregation during meiosis II (PubMed:15226378).
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Interacts with ECO1.
messages: Nucleus
messages: Present with 98 molecules/cell in log phase SD medium.

559292:YKR066C
gene id: 559292:YKR066C
uniprot id: P00431
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Forms a one-to-one complex with cytochrome c.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Present with 6730 molecules/cell in log phase SD medium.

559292:YPL022W
gene id: 559292:YPL022W
uniprot id: P06777
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Component of the nucleotide excision repair factor 1 (NEF1) complex consisting of RAD1, RAD10 and RAD14. Interacts with SAW1.
messages: Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD10 forms an endonuclease that specifically degrades single-stranded DNA.
messages: Nucleus
messages: Present with 1400 molecules/cell in log phase SD medium.

559292:YJL114W
gene id: 559292:YJL114W
uniprot id: P47023
names: Function
names: Miscellaneous
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty4 retrotransposons belong to the copia elements (pseudoviridae).

559292:YKL108W
gene id: 559292:YKL108W
uniprot id: P34252
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLD2 family.
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint. Also required for the proper activation of RAD53 in response to DNA damage and replication blocks.
messages: Interacts with DPB11.
messages: Nucleus
messages: Phosphorylated by CDC28 at the onset of S-phase. This phosphorylation, specifically phosphorylation of Thr-84 promotes interaction with DPB11 leading to DNA replication. Dephosphorylated by CDC14.
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YNL149C
gene id: 559292:YNL149C
uniprot id: P53903
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA2 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the processing and trafficking of GAS1 and PHO8 glycosylated proteins.
messages: Nucleus membrane

559292:YKL054C
gene id: 559292:YKL054C
uniprot id: P35732
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEF1 family.
messages: Cytoplasm
messages: Homodimer; may form higher order oligomers (PubMed:23993092). Interacts with the large RNA polymerase II subunit RPO21; the interaction is direct and serves to bridge RPO21 to the Elongin complex in a manner dependent on transcription stress (PubMed:15166235, PubMed:23993092). Interacts with RAD26 (PubMed:11859374). Interacts (via CUE domain) with the Elongin complex subunit ELA1 (via C-terminus); the interaction is direct (PubMed:23993092).
messages: Nucleus
messages: Present with 3380 molecules/cell in log phase SD medium.
messages: Proteolytically cleaved by the proteasome in response to transcription stress; the resulting N-terminal form constitutes the activated nuclear form and the C-terminal portion is degraded.
messages: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II (PubMed:11859374, PubMed:15166235, PubMed:15960978). Also involved in telomere length regulation (PubMed:15863512). Binds DNA (PubMed:15863512).
messages: The C-terminal part appears to promote nuclear export.
messages: Ubiquitinated at Lys-281 or Lys-288, and at Lys-328 or Lys-329. in a manner dependent on RSP5; ubiquitination accelerates its proteolytic processing by the proteasome.
messages: telomere

559292:YOR196C
gene id: 559292:YOR196C
uniprot id: P32875
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YER042W
gene id: 559292:YER042W
uniprot id: P40029
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product.
messages: Present with 3070 molecules/cell in log phase SD medium.

559292:YDR322C-A
gene id: 559292:YDR322C-A
uniprot id: P81449
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 4590 molecules/cell in log phase SD medium.

559292:YBR273C
gene id: 559292:YBR273C
uniprot id: P38349
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Interacts with CDC48.
messages: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
messages: Present with 2190 molecules/cell in log phase SD medium.

559292:YER005W
gene id: 559292:YER005W
uniprot id: P40009
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A divalent cation Ca(2+), Mg(2+) or Mn(2+).
messages: Activity is inhibited both by interaction with VMA13 and by V-ATPase acidification of the lumen. The activity of VMA13 is not required for YND1 inhibition.
messages: Belongs to the GDA1/CD39 NTPase family.
messages: Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis.
messages: Cells are partially resistant to E4orf4 and can partially suppress the spindle checkpoint defect in CDC55 deletion mutant. Does not suppress the rapamycin-resistance of CDC55 deletion mutant. YND1 and CDC55 double mutant is fully resistant to E4orf4. Deletion mutant suppresses the synthetic lethality of triple mutants, where UPC2 and ECM22 are knocked out along with either HAP1, ERG6 or ERG28.
messages: Golgi apparatus
messages: Interacts with activator subunit VMA13 of vacuolar H(+)-ATPase. Interacts with CDC55; this interaction is disrupted by adenovirus E4orf4, which remains associated with both YND1 and CDC55.
messages: Membrane
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YBR243C
gene id: 559292:YBR243C
uniprot id: P07286
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.
messages: Endoplasmic reticulum membrane
messages: Inhibited by tunicamycin.

559292:YOR344C
gene id: 559292:YOR344C
uniprot id: P33122
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus
messages: Present with 486 molecules/cell in log phase SD medium.
messages: Transcriptional activator of glycolytic gene expression, such as enolase genes (ENO1 and ENO2), glyceraldehyde-3-phosphate dehydrogenase gene (TDH), phosphoglycerate kinase (PGK1), phosphoglycerate mutase (PGM1), pyruvate kinase (PYK1) and triosephosphate isomerase (TPI1) genes. Binds DNA on E-box motifs: 5'-CANNTG-3'.

559292:YIL034C
gene id: 559292:YIL034C
uniprot id: P13517
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: Bud
messages: Bud tip
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: Present with 6770 molecules/cell in log phase SD medium.
messages: actin patch

559292:YCL054W-A
gene id: 559292:YCL054W-A
uniprot id: A0A0B7P221
names: Miscellaneous
messages: Shows evidence of translation. May be a new protein-coding gene that originated de novo from non-coding sequences, e.g. transcripts of unknown function that escape exonucleolytic degradation (stable unannotated transcripts or SUTs) and associate with ribosomes.

559292:YPL051W
gene id: 559292:YPL051W
uniprot id: Q02804
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Golgi apparatus
messages: Interacts with SYS1 and SLO1.
messages: Involved in the targeting of ARL1 to the Golgi. Can bind and hydrolyze GTP.
messages: Present with 1920 molecules/cell in log phase SD medium.

559292:YGL076C
gene id: 559292:YGL076C
uniprot id: P05737
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 101000 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL30 in yeast.

559292:YOR067C
gene id: 559292:YOR067C
uniprot id: P40351
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

559292:YMR001C
gene id: 559292:YMR001C
uniprot id: P32562
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Interacts with CDC48; the interaction is likely to result in CDC5 degradation.
messages: Present with 1480 molecules/cell in log phase SD medium.
messages: Protein kinase required for the cell cycle where it is involved in mitotic exit. A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Phosphorylates SCC1/MCD1 and NET1.

559292:YMR313C
gene id: 559292:YMR313C
uniprot id: P40308
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: A double deletion of TGL3 and TGL4, the 2 major TGA lipases, leads to fat yeast, rendering growing cells unable to degrade triglycerides.
messages: Lipid droplet
messages: Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate metabolic pathways (PubMed:10515935, PubMed:12682047, PubMed:16267052). Also catalyzes the acylation of lysophosphatidic acid (LPA). Important for efficient sporulation, but rather through its acyltransferase than lipase activity (PubMed:20016004).
messages: Loses its lipolytic activity in cells lacking nonpolar lipids.
messages: Present with 3210 molecules/cell in log phase SD medium.

559292:YDR082W
gene id: 559292:YDR082W
uniprot id: P38960
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.
messages: Interacts with CDC13 and TEN1.
messages: The C-terminal wHLH region seems to mediate telomere-specific function.
messages: telomere

559292:YOR104W
gene id: 559292:YOR104W
uniprot id: Q12057
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Not known. Seems to be able to provoque the non-Mendelian trait [PIN(+)] which is required for the de novo appearance of the [PSI(+)] prion.
messages: Present with 996 molecules/cell in log phase SD medium.

559292:YBR278W
gene id: 559292:YBR278W
uniprot id: P27344
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.
messages: DNA polymerase epsilon is a heterotetramer consisting of POL2, DPB2, DPB3 and DPB4.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YOR107W
gene id: 559292:YOR107W
uniprot id: Q99188
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: GTPase activating protein for GPA2. Negatively down-regulates glucose-induced cAMP signaling via GPA2.
messages: Interacts with GPA2.
messages: Nucleus

559292:YDR081C
gene id: 559292:YDR081C
uniprot id: P32896
names: Function
names: Miscellaneous
messages: Essential for the synthesis of pyruvate decarboxylase. May be important for a high basal level of PDC gene expression or play a positive role in the autoregulation control of PDC1 and PDC5.
messages: Present with 572 molecules/cell in log phase SD medium.

559292:YHL026C
gene id: 559292:YHL026C
uniprot id: P38740
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 830 molecules/cell in log phase SD medium.

559292:YLR318W
gene id: 559292:YLR318W
uniprot id: Q06163
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Catalytic subunit of the telomerase holoenzyme complex composed minimally of EST2 and the telomerase RNA template component.
messages: Deletion causes telomere shortening and senescence.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

559292:YIL164C
gene id: 559292:YIL164C
uniprot id: P40447
names: Caution
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
messages: Could be the product of a pseudogene. NIT1/YIL164C seems to be the N-terminal part of a putative nitrilase-like protein formed of NIT1/YIL164C and YIL165C.

559292:YJL103C
gene id: 559292:YJL103C
uniprot id: P42950
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERT1/acuK family.
messages: Nucleus
messages: Transcription factor which regulates nonfermentable carbon utilization (By similarity). Binds specifically to 5'-CGGN(8)CGG-3' and 5'-CGGN(9)CGG-3' sequences in the promoter region.

559292:YHL033C
gene id: 559292:YHL033C
uniprot id: P17076
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 238000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL8 in yeast.

559292:YKL205W
gene id: 559292:YKL205W
uniprot id: P33418
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Has been originally identified as involved in pre-tRNA splicing since its deletion accumulates pre-tRNAs (PubMed:7363329, PubMed:3031485). However, further studies have shown that it is actually a nuclear pore protein involved in transport of pre-tRNAs and mature tRNAs (PubMed:9774653).
messages: Interacts with CEX1, GSP1, GSP2, NSP1, NUP2 and UTP8.
messages: Leads to the accumulation of pre-tRNAs.
messages: Nucleus
messages: Present with 3490 molecules/cell in log phase SD medium.
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Preferentially interacts with tRNAs with mature 5'- and 3'-termini and does not distinguish between intron-containing and spliced tRNAs. In the nucleus binds to tRNA and to the Ran-GTPases GSP1 or GSP2 in their active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the tRNA from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

559292:YOR247W
gene id: 559292:YOR247W
uniprot id: Q08673
names: Function
names: Subcellular Location Annotation
messages: Cell surface
messages: Required to stabilize the cell wall in the absence of multiple GPI-anchored mannoproteins.
messages: cell wall

559292:YPR198W
gene id: 559292:YPR198W
uniprot id: P33335
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Drug export permease. Multi-copy suppressor of loss-of-function mutation of GAL11. Involved specifically in transcription of GAL4-dependent genes. Can link GAL4 with the basal transcription machinery if GAL11 is missing. Confers resistance to 10-N-nonyl acridine orange (NAO) and in general to cationic dyes.
messages: Membrane

559292:YML037C
gene id: 559292:YML037C
uniprot id: Q03703
names: Miscellaneous
messages: Present with 815 molecules/cell in log phase SD medium.

559292:YDL069C
gene id: 559292:YDL069C
uniprot id: P14066
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: CBS1 protein devoid of mitochondrial targeting sequences can enter mitochondria in vivo, possibly due to a bypass of the mitochondrial import system.
messages: Mitochondrion inner membrane
messages: Present with 556 molecules/cell in log phase SD medium.
messages: The in vitro imported CBS1 protein is functional and soluble indicating that the N-terminal part of CBS1 confers some binding to mitochondrial membranes.
messages: mRNA-specific translational activator of cytochrome b. The cytochrome b (COB) leader RNA may represent the target sequence for CBS1 and CBS2, tethering the COB mRNA to the inner mitochondrial membrane, where cotranslational insertion of cytochrome b into the membrane can occur.

559292:YER028C
gene id: 559292:YER028C
uniprot id: P39943
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the creA/MIG C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: DNA-binding transcriptional repressor involved in response to toxic agents such as ribonucleotide reductase inhibitor, hydroxyurea (HU).
messages: Down-regulated at low calcium levels.
messages: Nucleus
messages: Phosphorylated during genotoxic stress. DNA damage induces phosphorylation by SNF1 or the MEC1 pathway and leads to its inactivation, which allows induction of damage response genes.

559292:YMR051C
gene id: 559292:YMR051C
uniprot id: P0CX65
uniprot id: P0CX66
uniprot id: P0CX67
uniprot id: P0CX68
uniprot id: P0CX69
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR5 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ER2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-GR3 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-MR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YNL181W
gene id: 559292:YNL181W
uniprot id: P53878
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Present with 13900 molecules/cell in log phase SD medium.

559292:YPR183W
gene id: 559292:YPR183W
uniprot id: P14020
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Binds 1 divalent metal cation.
messages: Endoplasmic reticulum membrane
messages: Inhibited by acetylsalicylic acid (aspirin).
messages: Interacts with the C-terminus of SAC1, thereby sequestering it to the endoplasmic reticulum in exponentially growing cells. Under nutrient limitation conditions, this interaction is rapidly abolished.
messages: Present with 1885 molecules/cell in log phase SD medium.
messages: Repressed by aspirin.
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

559292:YDL235C
gene id: 559292:YDL235C
uniprot id: Q07688
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YPD1 family.
messages: Cytoplasm
messages: Interacts with the response regulatory domains of SLN1 and SSK1.
messages: Nucleus
messages: Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus.
messages: Present with 6330 molecules/cell in log phase SD medium.
messages: The phosphorelay mechanism involves the sequential transfer of a phosphate group from 'His-576' (H1) to 'Asp-1144' (D1) of SLN1, then to His-64 (H2) of YPD1 and finally to 'Asp-554' (D2) of SSK1 or 'Asp-427' (D2) of SKN7.

559292:YER172C
gene id: 559292:YER172C
uniprot id: P32639
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Interaction with PRP8 is important for recruitment to the U4/U6-U5 tri-snRNP complex. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Contains two helicase domains. The N-terminal helicase domain has catalytic activity by itself, contrary to the C-terminal helicase domain that may have a regulatory role and enhance the activity of the first helicase domain.
messages: Nucleus
messages: Present with 1440 molecules/cell in log phase SD medium.
messages: RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.

559292:YPR155C
gene id: 559292:YPR155C
uniprot id: Q12374
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCA2 family.
messages: Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase.
messages: Mitochondrion membrane
messages: Present with 2940 molecules/cell in log phase SD medium.

559292:YNL241C
gene id: 559292:YNL241C
uniprot id: P11412
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
messages: Present with 15000 molecules/cell in log phase SD medium.
messages: Shows growth defects in acetate-supplemented medium; the phenotype is enhanced by addition of hydrogen peroxide (increased oxidative stress) and/or double knockout of ZWF1 and YHM2 (PubMed:20371607). Decreases the cytosolic NADPH/NADP(+) ratio; this effect is enhanced in the presence of hydrogen peroxide (PubMed:20371607). Ribitol-5P absent from cell (PubMed:30240188). Decreases cellular levels of ribose-5P and ribulose-5P (PubMed:30240188). Decreases cytosolic levels of citrate and oxoglutarate in the presence of hydrogen peroxide (PubMed:20371607). Double knockouts of ZWF1 and YHM2 show an increased mitochondrial NADPH/NADP(+) ratio in the presence of hydrogen peroxide (PubMed:20371607). Reactive oxygen species (ROS) levels are moderately increased following hydrogen peroxide treatment; in double knockouts of YHM2 and ZWF1 there is a larger increase (PubMed:20371607).

559292:YGR277C
gene id: 559292:YGR277C
uniprot id: P53332
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 3610 molecules/cell in log phase SD medium.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity). Plays a role in the physiological regulation of the intracellular CoA concentration.

559292:YLR173W
gene id: 559292:YLR173W
uniprot id: Q06247
names: Subcellular Location Annotation
messages: Membrane

559292:YPR187W
gene id: 559292:YPR187W
uniprot id: P20435
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: Cytoplasm
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds.
messages: Nucleus
messages: Present with 6090 molecules/cell in log phase SD medium.

559292:YGL254W
gene id: 559292:YGL254W
uniprot id: P32805
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus
messages: Present with 2120 molecules/cell in log phase SD medium.

559292:YKL099C
gene id: 559292:YKL099C
uniprot id: P34247
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with EBP2, FAF1, MPP10, RPS16A and RRP14.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

559292:YJR090C
gene id: 559292:YJR090C
uniprot id: P24814
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Expressed constitutively at low levels.
messages: Interacts with SKP1. Component of the probable SCF(GRR1) complex containing CDC53, SKP1, RBX1 and GRR1.
messages: Membrane
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. Probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression.

559292:YPL189W
gene id: 559292:YPL189W
uniprot id: Q08929
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Expressed constitutively.
messages: Probable membrane-bound O-acyltransferase (By similarity). Together with GUP1, has an influence on the chemical composition of the yeast extracellular matrix (yECM) in yeast multicellular aggregates, such as biofilms and colonies (PubMed:25589358).
messages: Was originaly thought to be involved in active uptake of glycerol driven by electrogenic proton symport (PubMed:10931309), but has later been shown to be an acyltransferase and that effects on glycerol transport may be indirect (PubMed:15381122).

559292:YKL098W
gene id: 559292:YKL098W
uniprot id: P34246
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the MTC2 family.
messages: Decreases resistance to doxorubicin.
messages: May be involved in telomere capping.

559292:YJL167W
gene id: 559292:YJL167W
uniprot id: P08524
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:8096487). ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:8096487). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672).

559292:YGL065C
gene id: 559292:YGL065C
uniprot id: P43636
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with ALG1.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Present with 1840 molecules/cell in log phase SD medium.

559292:YOR113W
gene id: 559292:YOR113W
uniprot id: P41696
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Potential transcription factor; suppressor for a mitochondrial RNA polymerase mutant.
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YEL033W
gene id: 559292:YEL033W
uniprot id: P32633
names: Function
names: Subcellular Location Annotation
messages: May be involved in telomere capping.
messages: Membrane

559292:YBL063W
gene id: 559292:YBL063W
uniprot id: P28742
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
messages: Might be dimeric.
messages: Present with 56 molecules/cell in log phase SD medium.
messages: Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediate by KAR3.
messages: spindle

559292:YBR299W
gene id: 559292:YBR299W
uniprot id: P38158
names: Miscellaneous
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Present with 4030 molecules/cell in log phase SD medium.

559292:YER184C
gene id: 559292:YER184C
uniprot id: P39961
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Confers sensitivity to calcofluor white, and prevents growth on non-fermentable carbon sources such as glycerol or lactate (PubMed:11353088, PubMed:24998441). Sensitizes cells to oxidative stress (PubMed:24998441). Leads to a decrease in peroxisome abundance when oleate was used as a sole carbon source (PubMed:24998441).
messages: Nucleus
messages: Transcriptional activator required for growth on non-fermentable carbon sources and that regulates genes involved in fatty acid utilization (PubMed:11353088, PubMed:24998441). Acts as a direct activator that binds the promoters of oleate utilizing genes, encoded key enzymes in beta-oxidation and NADPH regeneration (POX1, FOX2,POT1 and IDP2), the glyoxylate shunt (MLS1 and ICL1), and gluconeogenesis (PCK1 and FBP1) (PubMed:24998441). Regulates also the abundance of peroxisomes that are vital for fatty acid oxidation (PubMed:24998441).

559292:YCR106W
gene id: 559292:YCR106W
uniprot id: P25611
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Zinc cluster transcription factor involved in resistance to cycloheximide.

559292:YBR212W
gene id: 559292:YBR212W
uniprot id: P32831
names: Function
names: Miscellaneous
messages: May be an RNA-binding protein involved in control of an RNA processing pathway that influences the regulation of cell growth in early log phase. Can bind to RNA and single-stranded DNA but not double-stranded DNA.
messages: Present with 1540 molecules/cell in log phase SD medium.

559292:YKL189W
gene id: 559292:YKL189W
uniprot id: P32464
names: Miscellaneous
names: Similarity
messages: Belongs to the Mo25 family.
messages: Present with 1280 molecules/cell in log phase SD medium.

559292:YAR064W
gene id: 559292:YAR064W
uniprot id: P39563
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:YEL050C
gene id: 559292:YEL050C
uniprot id: P32611
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uL2m has a Na/K ligand binding site.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 1600 molecules/cell in log phase SD medium.

559292:YBR200W-A
gene id: 559292:YBR200W-A
uniprot id: Q3E755
names: Subcellular Location Annotation
messages: Secreted

559292:YNL059C
gene id: 559292:YNL059C
uniprot id: P53946
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family.
messages: Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.
messages: Nucleus
messages: Present with 2170 molecules/cell in log phase SD medium.
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

559292:YFL048C
gene id: 559292:YFL048C
uniprot id: P43555
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP46/EMP47 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomers. Interacts with EMP46 in the endoplasmic reticulum membrane. Interacts with the coatomer proteins COP1, SEC21 and SEC23.
messages: Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing. Required for the endoplasmic reticulum exit of EMP46.
messages: Present with 2900 molecules/cell in log phase SD medium.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

559292:YFR014C
gene id: 559292:YFR014C
uniprot id: P27466
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Important in cellular regulation.
messages: Multimeric.
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:YJR064W
gene id: 559292:YJR064W
uniprot id: P40413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

559292:YKR083C
gene id: 559292:YKR083C
uniprot id: P36162
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD2 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: Present with 279 molecules/cell in log phase SD medium.
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle

559292:YNL312W
gene id: 559292:YNL312W
uniprot id: P26754
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the replication factor A protein 2 family.
messages: Binds to single-stranded sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation (CAR1). Stimulates the activity of a cognate strand exchange protein (SEP1). It cooperates with T-AG and DNA topoisomerase I to unwind template DNA containing the simian virus 40 origin of DNA replication.
messages: Heterotrimer of 69, 36, and 13 kDa chains. The DNA-binding activity may reside exclusively on the 69 kDa subunit. Interacts with MCM10.
messages: Nucleus
messages: Phosphorylated in a cell cycle-dependent manner with phosphorylation increasing at the entry in S phase and dephosphorylation occurring at mitosis.
messages: Present with 6080 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YDR468C
gene id: 559292:YDR468C
uniprot id: Q03322
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Early endosome membrane
messages: Interacts in a SNARE-pin with the SNAREs TLG2 (Qa), VTI1 (Qb), and SNC1 or SNC2 (R). Interacts with VPS51 of the VFT (or GARP) complex.
messages: Late endosome membrane
messages: Palmitoylated by SWF1, which prevents its recognition and ubiquitination by TUL1 and its subsequent degradation.
messages: Phosphorylated at Thr-31 by TPK1 and dephosphorylated by SIT4.
messages: SNARE protein (of Qc type) involved in membrane fusion probably in retrograde traffic of cytosolic double-membrane vesicles derived from both, early and possibly late endosomes/PVC (prevacuolar compartment) back to the trans-Golgi network (TGN or late Golgi). It has been reported to function both as a (target membrane) t-SNARE and as a (vesicle) v-SNARE. Upon vesicle tethering to the target membrane, which requires additional proteins, a SNARE-pin is formed. This is a very stable 4 parallel alpha-helical coil bundle consisting of 4 SNARE domains (usually one of each type: Qa, Qb, Qc, and R), of which at least one is anchored in the opposite membrane. The formation of the SNARE-pin is believed to bring the two membranes in close proximity and to provide the energy to drive membrane fusion. Through its interaction with the VFT (or GARP) complex, it may also contribute to vesicle recognition specificity and tethering. Regulation of SNARE-pin formation also seems to depend on the phosphorylation state of the protein, phosphorylation by TPK1 causing inhibition and dephosphorylation by SIT4 activation.
messages: trans-Golgi network membrane

559292:YDR471W
gene id: 559292:YDR471W
uniprot id: P0C2H7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 22900 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL27 in yeast.

559292:YKL157W
gene id: 559292:YKL157W
uniprot id: P32454
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the cellular supply of leucine from externally offered leucine-containing dipeptide substrates.
messages: Mitochondrion
messages: Periplasm
messages: Present with 2910 molecules/cell in log phase SD medium.

559292:YKL130C
gene id: 559292:YKL130C
uniprot id: P36068
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE2 family.
messages: Cytoplasm
messages: Homodimer and homotetramer. Interacts with LOC1, MYO4, PUF6, SHE3 and with RNA pol II subunits RPO21, SPT4 and SPT5.
messages: Nucleus
messages: Present with 4070 molecules/cell in log phase SD medium.
messages: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruits the MYO4-SHE3 complex to the ASH1 mRNA. Recruits also LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA.

559292:YDR210W
gene id: 559292:YDR210W
uniprot id: Q03482
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Cell membrane
messages: Present with 13100 molecules/cell in log phase SD medium.

559292:YJR144W
gene id: 559292:YJR144W
uniprot id: P32787
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGM101 family.
messages: Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA.
messages: mitochondrion nucleoid

559292:YKL021C
gene id: 559292:YKL021C
uniprot id: P20484
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 60S pre-ribosomal particles.
messages: Essential for cell growth. Plays a role in assembly of 60S pre-ribosomal particles in the nucleolus. Also required for replication of the M1 double-stranded RNA of the L-A virus. This latter function may reflect an enhanced requirement for free 60S ribosomal particles for the translation of viral mRNAs which lack poly-A tails.
messages: Nucleus membrane
messages: Present with 3730 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YOR039W
gene id: 559292:YOR039W
uniprot id: P38930
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Phosphorylated by alpha subunit.
messages: Present with 7160 molecules/cell in log phase SD medium.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).
messages: Tetramer composed of an alpha subunit, an alpha' subunit, one beta subunit and one beta' subunit (PubMed:12242279). Interacts with FACT subunits POB3 and SPT16 (PubMed:12242279). Interaction with YTA7 (PubMed:22156209).
messages: The N-terminus is blocked.

559292:YNL287W
gene id: 559292:YNL287W
uniprot id: P32074
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endosome
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts (via C-terminus) with GEA1 (via N-terminal region) and KEI1 (via C-terminal region).
messages: Present with 77900 molecules/cell in log phase SD medium.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

559292:YDR106W
gene id: 559292:YDR106W
uniprot id: Q04549
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP10 subfamily.
messages: Pointed-end-associated component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. May regulate the association of the dynactin complex with the plasma membrane.
messages: Self-associates. Component of the dynactin complex composed of at least ARP1, JNM1, NIP100 and ARP10. Dynactin comprises a short rod of the ARP1 filament attached to ARP10 at its pointed-end and probably associated with the capping protein at its barbed-end. The rod is implicated in dynein cargo binding. A sidearm formed by NIP100 projects from the ARP1 filament and is implicated in motor binding (By similarity). Interacts with ARP1 and JNM1.
messages: cytoskeleton

559292:YOL139C
gene id: 559292:YOL139C
uniprot id: P07260
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A (TIF1/TIF2), eIF4E (TIF45) and eIF4G (TIF4631 or TIF4632) (By similarity). Interacts with PAT1 in a RNA-dependent manner. eIF4E is also known to interact with other partners.
messages: Present with 14200 molecules/cell in log phase SD medium.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

559292:YPL037C
gene id: 559292:YPL037C
uniprot id: Q02642
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II. Can enhance DNA binding of the GAL4 protein activator.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and either EGD1 or BTT1. NAC associates with ribosomes via EGD1 or BTT1, and with the CCR4-NOT complex.
messages: Present with 18000 molecules/cell in log phase SD medium.
messages: Ubiquitinated by the NOT4 E3 ligase and the UBC4 E2 ubiquitin conjugation enzyme.

559292:YBR068C
gene id: 559292:YBR068C
uniprot id: P38084
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan.
messages: Present with 8660 molecules/cell in log phase SD medium.

559292:YDL244W
gene id: 559292:YDL244W
uniprot id: Q07748
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

559292:YOR054C
gene id: 559292:YOR054C
uniprot id: Q08438
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.
messages: Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis. Acts as an inhibitory subunit of protein phosphatase PPZ1, which is involved in many cellular processes such as G1-S transition or salt tolerance.
messages: Interacts with the C-terminal domain of PPZ1. Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex, a heterotrimer composed of CAB3, SIS2 and VHS3.

559292:YDR305C
gene id: 559292:YDR305C
uniprot id: P49775
names: Cofactor
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock.
messages: Cytoplasm
messages: Divalent metal cations. Mn(2+) is the preferred ion.
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus
messages: Present with 1920 molecules/cell in log phase SD medium.

559292:YOR296W
gene id: 559292:YOR296W
uniprot id: Q08748
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YKL183W
gene id: 559292:YKL183W
uniprot id: P34234
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LOT5 family.
messages: By cold.
messages: Cytoplasm
messages: Nucleus
messages: Present with 5930 molecules/cell in log phase SD medium.

559292:YJL109C
gene id: 559292:YJL109C
uniprot id: P42945
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEATR1/UTP10 family.
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). Involved in ribosome biosynthesis.
messages: Mitochondrion
messages: Present with 18200 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YGL061C
gene id: 559292:YGL061C
uniprot id: P53168
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DUO1 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: Present with 996 molecules/cell in log phase SD medium.
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle pole

559292:YLR254C
gene id: 559292:YLR254C
uniprot id: Q06568
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nudE family.
messages: Nucleus
messages: Required for nuclear migration to the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
messages: Self-associates. Interacts with PAC1.
messages: cytoskeleton

559292:YOR153W
gene id: 559292:YOR153W
uniprot id: P33302
names: Activity Regulation
names: Biotechnology
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Active efflux of weakly charged organic compounds of 90 cubic Angstroms to 300 cubic Angstroms surface volume. Confers resistance to numerous chemicals including cycloheximide, sulfomethuron methyl, steroids, antiseptics, antibiotics, anticancer, herbicides, mycotoxins, insecticides, ionophores, alkaloids, flavonoids, phenothiazines, organotin compounds, carbazoles, lysosomotropic aminoesters, detergents, rhodamines and other fluorophores, azoles and other antifungals. Exhibits nucleoside triphosphatase activity.
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Cell membrane
messages: Expressed during exponential growth. Transcription is transiently activated within 40 min after induction by benomyl and other toxic chemicals. Multidrug resistance and PDR5 mRNA level are activated by the transcription regulators PDR1, PDR3, YAP1, YAP2, STB5 and by the mitochondrial rho zero mutation. Mutations or deletion in the PDR1 or PDR3 transcription factors strongly activate PDR5 mRNA and PDR5 translation. The transcription regulator RDR1 represses PDR5 expression.
messages: FK506, isonitrile, enniatin, RU49953, kitasatospora E420, staurosporine CGP42700, prenyl-flavonoids, D-octapeptides were found to be inhibitors in vivo. Vanadate and oligomycin were found to be inhibitors in vitro.
messages: Full-sized PDR5 orthologs are found only in fungi and plants. Their topology and substrate specificity are distinct from mammalian MDR transporters.
messages: Present with 42000 molecules/cell in log phase SD medium in log phase SD medium.
messages: Strains lacking PDR5 are used for toxicity tests. Strains overexpressing PDR5 are used for screening antifungal sensitizers.
messages: The N-terminal ABC transporter domain (positions 161 to 410) contains degenerated Walker A and B ATP-binding motifs, suggesting that it may be less efficient in ATP binding or not functional at all. This is a distinctive feature of the PDR subfamily.
messages: The unusual length of the two extracellular loops at positions 686 to 774 and 1408 to 1476 is another specific feature of the PDR subfamily which may have an important role for function.
messages: This protein has been 'adopted' by Andre Goffeau from the Catholic University of Louvain (Belgium). The above-mentioned scientist has agreed to help us to curate information available on this protein. We are grateful to that person for committing precious time to help producing annotation useful to the whole community. However, that person is not responsible for any errors or omissions in this UniProtKB/Swiss-Prot entry. If you have found something wrong or missing in this entry you should submit an update report to: help@uniprot.org.
messages: Ubiquitinylation mediates endocytosis and vacuolar degradation. Phosphorylation by casein kinase I stabilizes the protein half-life.

559292:YOR101W
gene id: 559292:YOR101W
uniprot id: P01119
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by guanine nucleotide-exchange factor (GEF) CDC25 and inactivated by GTPase-activating proteins (GAPs) IRA1 and IRA2.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Farnesylated by RAM1-RAM2, which is required for targeting RAS1 to the cytoplasmic site of the endoplasmic reticulum, where proteolytic processing of the C-terminus by RCE1 and methylation of the resulting carboxyl group by STE14 occurs.
messages: Palmitoylated by the ERF2-SHR5 complex, which is required for proper plasma membrane localization of RAS1.
messages: Present with 2050 molecules/cell in log phase SD medium.
messages: The S.cerevisiae Ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-AMP.

559292:YIL015W
gene id: 559292:YIL015W
uniprot id: P12630
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: By alpha factor.
messages: It is found only in a mating type cells.
messages: Present with 672 molecules/cell in log phase SD medium.
messages: Secreted
messages: This protein called 'barrier activity' is excreted by yeast cells mating type a. It is probably a protease that cleaves alpha-factor and thus acts as an antagonist of this mating pheromone and establishes optimal pheromone concentration for conjugation.

559292:YDR045C
gene id: 559292:YDR045C
uniprot id: Q04307
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination.
messages: nucleolus

559292:YBR081C
gene id: 559292:YBR081C
uniprot id: P35177
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 1.8 MDa SAGA complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. SPT7 is transcriptional activator of TY elements and other genes.
messages: Nucleus
messages: Present with 2360 molecules/cell in log phase SD medium.

559292:YNL259C
gene id: 559292:YNL259C
uniprot id: P38636
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATX1 family.
messages: Cytoplasm
messages: Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.

559292:YCL021W-A
gene id: 559292:YCL021W-A
uniprot id: Q96VH3
names: Subcellular Location Annotation
messages: Membrane

559292:YNR027W
gene id: 559292:YNR027W
uniprot id: P53727
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyridoxine kinase family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 6580 molecules/cell in log phase SD medium.
messages: Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity). Important for bud site selection.

559292:YJR051W
gene id: 559292:YJR051W
uniprot id: P21375
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per monomer.
messages: Causes increased sensitivity to hypertonic growth medium.
messages: Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (FRD1), essential for anaerobic growth. Involved in maintaining redox balance during oxygen deficiency conditions. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2).
messages: Mitochondrion
messages: Present with 432 molecules/cell in log phase SD medium.

559292:YOR109W
gene id: 559292:YOR109W
uniprot id: Q12271
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptojanin family.
messages: Cytoplasm
messages: Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Interacts with BSP1 and CHC1.
messages: Present with 1520 molecules/cell in log phase SD medium.
messages: The 5-phosphatase domain (residues 568 to 856) selectively removes the phosphate group at the 5' position of inositol of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
messages: The C-terminal proline-rich domain is required for the function and associates with clathrin heavy chain CHC1.
messages: The SAC1 domain is capable of hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).

559292:YLL038C
gene id: 559292:YLL038C
uniprot id: Q07872
names: Miscellaneous
messages: Present with 1960 molecules/cell in log phase SD medium.

559292:YML121W
gene id: 559292:YML121W
uniprot id: Q00582
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions (PubMed:26510498, PubMed:32801125, PubMed:28993463). Also required for TORC1 inactivation during nitrogen starvation (PubMed:28993463). Required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272). Functionally associated with the inorganic phosphate transporter PHO84, and may be involved in regulating its function or localization (PubMed:1620108).
messages: Heterodimer; with GTR2 (PubMed:21816923). Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1 (PubMed:16732272). Interacts with GTR2; the interaction is direct (PubMed:21816923). Interacts with TOR1 (PubMed:29698392).
messages: Present with 907 molecules/cell in log phase SD medium.
messages: Sensitive to rapamycin (TORC1 signaling-inhibitor) (PubMed:28993463). Decreases and delays activation of TORC1 signaling in nitrogen-replete conditions (glutamine nitrogen source) (PubMed:29698392). Abnormal punctate localization of PIB2 and TOR1 in nitrogen-replete conditions (glutamine nitrogen source) (PubMed:29698392, PubMed:32801125, PubMed:28993463). Increases cellular levels of glutamine and alanine during high hydrostatic pressure (mechanical stress) (PubMed:32801125). Sensitive to high hydrostatic pressure (PubMed:32801125). Resistance to tunicamycin (endoplasmic reticulum stressor) administered together with FK506 (calcineurin inhibitor) (PubMed:26510498). Normal localization of KOG1 and TOR1 to the vacuolar membrane (PubMed:28483912). Simultaneous disruption of PIB2 results in TOR1 mislocalization and loss of TORC1 activity and viability (PubMed:29698392).
messages: Vacuole membrane

559292:YOR338W
gene id: 559292:YOR338W
uniprot id: Q99326
names: Induction
messages: By heat stress.

559292:YJR152W
gene id: 559292:YJR152W
uniprot id: P15365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Allantoate permease family.
messages: Component of the allantoate transport system.
messages: Membrane

559292:YKL203C
gene id: 559292:YKL203C
uniprot id: P32600
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Phosphatidylinositol 3-kinase homolog, component of both TORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4 (PubMed:10198052, PubMed:10329624, PubMed:10604478, PubMed:11741537, PubMed:15620355, PubMed:7606777, PubMed:8741837, PubMed:9539725, PubMed:9843498). In nutrient-rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) YPK3, activating YPK3 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:25767889). Phosphorylates kinase SCH9 at 6 amino acids in the C-terminus, activating SCH9 kinase activity to properly regulate ribosome biogenesis, translation initiation, and entry into stationary phase (PubMed:17560372). TORC2 regulates cell cycle-dependent polarization of the actin-cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway by activating the RHO1 guanine nucleotide exchange factor ROM2. TORC2 phosphorylates the AGC kinase YPK2, an upstream…
messages: The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B) (PubMed:12408816, PubMed:12631735). TORC1 binds to and is inhibited by FKBP-rapamycin (PubMed:12408816). Interacts with PIB2; following activation of PIB2 by glutamine (PubMed:29698392). The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11 (PubMed:12408816, PubMed:12631735, PubMed:16002396, PubMed:16959779). TORC2 likely forms a homodimer (PubMed:16002396). Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin (PubMed:12408816). Interacts with SLM1 and SLM2 (PubMed:15689497, PubMed:16959779).
messages: Vacuole membrane

559292:YDR260C
gene id: 559292:YDR260C
uniprot id: Q12379
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. SWM1 is required for APC/C activity in meiosis.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1. SWM1 interacts directly with CDC23 and APC5, and is required to tether APC9, CDC16, CDC26 and CDC27 to the complex.

559292:YGL261C
gene id: 559292:YGL261C
uniprot id: P0CE92
uniprot id: P0CE93
uniprot id: Q3E770
names: Similarity
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.

559292:YGR203W
gene id: 559292:YGR203W
uniprot id: P42937
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPI phosphatase family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 2310 molecules/cell in log phase SD medium.
messages: Protein phosphatase.

559292:YJR013W
gene id: 559292:YJR013W
uniprot id: P47088
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.

559292:YMR125W
gene id: 559292:YMR125W
uniprot id: P34160
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NCBP1 family.
messages: Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of STO1/CBC1 and CBC2 that interacts with capped RNAs. The complex interacts strongly with the importin subunit alpha SRP1. The SRP1-CBC trimer also binds to capped RNAs, but formation of the importin alpha/beta heterodimer upon binding of KAP95 to SRP1 in the cytoplasm causes dissociation of CBC from the RNA. The CBC complex is part of the commitment complex 1 (CC1), binding to the cap of pre-mRNA and interacting with U1 snRNP subunits MUD2 and SNU56. The CBC complex is part of the NRD1 complex, composed of CBC2, NAB1, NRD1, SEN1 and STO1/CBC2. The CBC complex also interacts with NPL3 and eIF4G (TIF4631 and TIF4632).
messages: In contrast to metazoans, where the CBC complex is involved in the nuclear export of capped U snRNAs, it is believed that in yeast, U snRNAs are not exported from the nucleus and U snRNPs are assembled in the nucleus from RNAs and imported proteins.
messages: Nucleus
messages: Present with 11300 molecules/cell in log phase SD medium.
messages: perinuclear region

559292:YBR109C
gene id: 559292:YBR109C
uniprot id: P06787
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calmodulin family.
messages: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.
messages: Component of the SPC110 complex containing at least CMD1, SPC29, SPC42 and SCP110. Interacts with SPC110.
messages: The N-terminus is blocked.
messages: This protein has three functional calcium-binding sites.
messages: spindle pole body

559292:YPR135W
gene id: 559292:YPR135W
uniprot id: Q01454
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Accessory factor for DNA replication. It plays a role in accurately duplicating the genome in vivo.
messages: Nucleus
messages: Present with 3280 molecules/cell in log phase SD medium.

559292:YKL090W
gene id: 559292:YKL090W
uniprot id: P36075
names: Subunit
messages: Binds to ubiquitin.

559292:YDL180W
gene id: 559292:YDL180W
uniprot id: Q12301
names: Subcellular Location Annotation
messages: Vacuole membrane

559292:YPR021C
gene id: 559292:YPR021C
uniprot id: Q12482
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.
messages: Mitochondrion inner membrane

559292:YKR088C
gene id: 559292:YKR088C
uniprot id: P36164
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TVP38/TMEM64 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking and spindle migration.
messages: Interacts with YIP5.
messages: Present with 11300 molecules/cell in log phase SD medium.
messages: The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.

559292:YLR028C
gene id: 559292:YLR028C
uniprot id: P54113
names: Domain
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PurH family.
messages: Homodimer (Possible).
messages: Present with 7700 molecules/cell in log phase SD medium.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

559292:YPL150W
gene id: 559292:YPL150W
uniprot id: Q12152
names: Function
names: Induction
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: By methyl methanesulfonate (MMS).
messages: Putative serine/threonine-protein kinase.

559292:YDR389W
gene id: 559292:YDR389W
uniprot id: P17121
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: GTPase-activating protein for RHO1. Must be involved in the normal assembly or function or both of actin. Plays an essential role only at low temperatures.
messages: Present with 1420 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YMR234W
gene id: 559292:YMR234W
uniprot id: Q04740
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Present with 149 molecules/cell in log phase SD medium.

559292:Q0110
gene id: 559292:Q0110
uniprot id: P03873
names: Function
names: Miscellaneous
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
messages: Encoded from partially processed COB mRNA that terminates with the in-frame coding sequence of the second intron.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: In the N-terminal section; belongs to the cytochrome b family.
messages: Mitochondrion inner membrane
messages: The variant in strain Capensis / YB4237 has additional DNA endonuclease (I-ScaI) activity promoting intron homing, which makes intron 2 of the COB gene highly mobile (PubMed:8670880). Introduction of 2 (Ala-355 and His-382) of its 4 variant residues into other strains is sufficient for acquisition of endonuclease activity of the corresponding mRNA maturases and for induction of intron mobility (PubMed:8670880).
messages: This protein is responsible for splicing and maturation of cytochrome b mRNA. Specifically, it may be responsible for the splicing specificity of the second intron.

559292:YDR388W
gene id: 559292:YDR388W
uniprot id: P39743
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds to actin. Interacts with ABP1, GYL1, GYP5, PCL2 and YBR108W.
messages: Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Could be implicated in cytoskeletal reorganization in response to environmental stresses and could act in the budding site selection mechanism.
messages: Phosphorylated redundantly by cyclin-dependent kinase PHO85 in association with PCL1,2-type cyclins or by MAP kinase FUS3. Phosphorylation inhibits interaction with complexes involved in actin cytoskeleton function.
messages: Present with 14600 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YBL098W
gene id: 559292:YBL098W
uniprot id: P38169
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Deletion of BNA4 suppresses the toxicity of a mutant HD/HTT fragment.
messages: Mitochondrion outer membrane
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YCR028C-A
gene id: 559292:YCR028C-A
uniprot id: P32445
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer. Interacts with PIF1.
messages: Mitochondrion
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: This protein binds preferentially and cooperatively to single-stranded DNA (ssDNS). Involved in mitochondrial DNA replication. Stimulates PIF1 helicase activity.

559292:YPR055W
gene id: 559292:YPR055W
uniprot id: P32855
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC8 family.
messages: Cell membrane
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Cytoplasm
messages: The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

559292:YPL166W
gene id: 559292:YPL166W
uniprot id: Q12092
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG29 family.
messages: Forms a stable complex with ATG17 and ATG31. Interacts directly with ATG31. The ATG17-ATG29-ATG31 complex interacts with the ATG1-ATG13 complex. Note=The interaction with the ATG1-ATG13 complex is induced by starvation.
messages: Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.
messages: Preautophagosomal structure
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YFR045W
gene id: 559292:YFR045W
uniprot id: P43617
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane

559292:YLL054C
gene id: 559292:YLL054C
uniprot id: Q12244
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 339 molecules/cell in log phase SD medium.
messages: Required for growth on non-fermentable carbon sources.

559292:YLR069C
gene id: 559292:YLR069C
uniprot id: P25039
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion
messages: Present with 6348 molecules/cell in log phase SD medium.
messages: The precursor is processed in two steps involving mitochondrial intermediate peptidase (MIP) and mitochondrial processing peptidase (MPP).

559292:YOR136W
gene id: 559292:YOR136W
uniprot id: P28241
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically regulated by several compounds including AMP, NAD(+), and citrate.
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Mitochondrion matrix
messages: Octamer of two non-identical subunits IDH1 and IDH2.
messages: Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
messages: Present with 43100 molecules/cell in log phase SD medium.

559292:YCL001W
gene id: 559292:YCL001W
uniprot id: P25560
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Golgi apparatus membrane
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Required for correct localization of SEC12, SEC71 and SEC63 in the endoplasmic reticulum.
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YAL003W
gene id: 559292:YAL003W
uniprot id: P32471
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A. The 30-fold higher concentration of GTP compared to GDP in cells favors the formation of eEF1A-GTP, which rapidly forms a ternary complex with aminoacyl-tRNA that in turn displaces eEF1B from the complex.
messages: S-thiolated in response to oxidative stress, probably inhibiting the protein and causing a reduction in protein synthesis.
messages: The C-terminus (pos. 119-205) exhibits guanine nucleotide exchange activity.
messages: The eukaryotic elongation factor 1 complex (eEF1) is probably a heterohexamer. Two trimeric complexes, each composed of eEF1A (TEF1 or TEF2), eEF1Balpha (EFB1) and eEF1Bgamma (CAM1 or TEF4), are probably dimerized via the eF1Bgamma subunits. eEF1Balpha interacts directly with eEF1A. eEF1Balpha and eEF1Bgamma form the eEF1B subcomplex with the GEF activity.

559292:YGL191W
gene id: 559292:YGL191W
uniprot id: P32799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). COX13 interacts with COX1 and COX3 on the intermembrane space (IMS) and COX4 on the matrix side (PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

559292:YJL006C
gene id: 559292:YJL006C
uniprot id: P46962
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family.
messages: CTDK-I consists of three subunits, CTK1, CTK2 and CTK3 (also called alpha, beta and gamma). Interacts with CTK1. Heterodimerization with CTK3 is required to protect this subunit from degradation.
messages: Cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase II transcriptional elongation, and as part of the CTDK-I complex, pre-mRNA 3'-end processing and SET2 mediated H3K36 methylation. Together with CTK3, required for CTK1 CTD kinase activation. Required for DNA damage induced transcription. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus.
messages: Null mutants are viable, but grow more slowly than wild-type cells at 30 degrees Celsius. They are cold-sensitive, failing to grow at 12 degrees Celsius. They display flocculent growth in liquid media and they show abnormal cell morphologies, for example, a significant fraction of the cells are greatly enlarged. Deletion mutant is sensitive to the DNA synthesis inhibitor hydroxyurea (HU) and UV irradiation.
messages: Phosphorylated. Ubiquitinated. Phosphorylation and ubiquitination lead to degradation in growth-related way by the ubiquitin-proteasome pathway. Neither phosphorylation nor degradation requires association with CTK1.
messages: Present with 1590 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR136C
gene id: 559292:YLR136C
uniprot id: P47977
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay. Also destabilizes target mRNA by modulating 3'-end processing, creating extended transcripts that are prone for degradation.
messages: By transcription factors AFT1 and AFT2 in response to iron deficiency.
messages: Interacts with DHH1.
messages: Nucleus
messages: P-body

559292:YJL046W
gene id: 559292:YJL046W
uniprot id: P47051
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
messages: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
messages: Monomer.

559292:YER068W
gene id: 559292:YER068W
uniprot id: P34909
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Cytoplasm
messages: Forms a NOT protein complex that comprises NOT1, NOT2, NOT3, NOT4 and NOT5. Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.
messages: Nucleus
messages: Present with 4280 molecules/cell in log phase SD medium.

559292:YML113W
gene id: 559292:YML113W
uniprot id: P13483
names: Function
names: Miscellaneous
names: Subunit
messages: Binds as a dimer or higher oligomer.
messages: DNA-binding protein that recognizes oligo(A).oligo(T) tracts (A.T DNA). Can bind to any 11 bp sequence in which 10 bases conform to an uninterrupted oligo(A).oligo(T) tract.
messages: Present with 4700 molecules/cell in log phase SD medium.

559292:YBR221C
gene id: 559292:YBR221C
uniprot id: P32473
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Mitochondrion matrix
messages: Present with 9970 molecules/cell in log phase SD medium.
messages: Pyruvate dehydrogenase (E1) is a tetramer of 2 alpha and 2 beta subunits. Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

559292:YCR067C
gene id: 559292:YCR067C
uniprot id: P25365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Putative guanine nucleotide-exchange factor (GEF) involved in the formation or budding of transport vesicles from the ER. Positive regulator of SAR1 probably through inhibition of the GTPase activation by SEC23.

559292:YLR341W
gene id: 559292:YLR341W
uniprot id: Q06134
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for spore wall assembly and ascus formation.

559292:YPR045C
gene id: 559292:YPR045C
uniprot id: Q12049
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THP3 family.
messages: Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation. May also be involved in pre-mRNA splicing.
messages: Interacts with CSN12 and SEM1.
messages: Nucleus
messages: Present with 3360 molecules/cell in log phase SD medium.

559292:YIL064W
gene id: 559292:YIL064W
uniprot id: P40516
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Defects at both very early and later stages of endocytic transport in cells.
messages: Present with 1620 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-316'. May play a role in intracellular transport.

559292:YPR158W-B
gene id: 559292:YPR158W-B
uniprot id: P0C2J0
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YPR158W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YGR240C
gene id: 559292:YGR240C
uniprot id: P16861
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.
messages: Mitochondrion outer membrane
messages: Present with 89800 molecules/cell in log phase SD medium.

559292:YOL131W
gene id: 559292:YOL131W
uniprot id: Q08270
names: Induction
messages: By the zinc-responsive transcription factor ZAP1.

559292:YLR146C
gene id: 559292:YLR146C
uniprot id: Q12455
names: Miscellaneous
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.
messages: Present with 3870 molecules/cell in log phase SD medium.

559292:YER148W
gene id: 559292:YER148W
uniprot id: P13393
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Binds DNA as monomer. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. Interacts with TFC8.
messages: General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus

559292:YNL302C
gene id: 559292:YNL302C
uniprot id: P07281
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS19 is required for proper maturation of the small (40S) ribosomal subunit. Binds to 40S pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA (PubMed:16159874).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Disruption of a single RPS19 gene reduces cell growth; a double disruption is lethal. Depletion experiments show the proteins are required for correct maturation of precursor rRNA to generate the 18S small rRNA. A specific site between the 18S and 5.8S precursors (site A2 in ETS1) is not cleaved in disruption mutants. Partially assembled ribosomes are retained in the nucleolus rather than being exported to the cytoplasm. All effects are exacerbated in the double disruption. Increases association of NOC4 with 20/21S pre-rRNA, decreases association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.
messages: Present with 3440 molecules/cell in log phase SD medium.
messages: Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.
messages: There are 2 genes for eS19 in yeast.

559292:YLL034C
gene id: 559292:YLL034C
uniprot id: Q07844
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Involved in ribosome biogenesis. Seems to be required for restructuring nucleoplasmic 60S pre-ribosomal particles to make them competent for nuclear export.
messages: Present with 4490 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR170C
gene id: 559292:YLR170C
uniprot id: P35181
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1) (PubMed:10564262). AP-1 interacts with clathrin (PubMed:10564262). Also a component of the AP-1R complex composed of at least APM2, APL4 and APS1 (PubMed:26658609).
messages: Belongs to the adaptor complexes small subunit family.
messages: Component of the adapter complexes which link clathrin to receptors in coated vesicles (PubMed:10564262). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (PubMed:10564262). AP19 is probably a subunit of the Golgi membrane adapter (PubMed:10564262). Component of the AP-1-related (AP-1R) complex, an adapter protein complex that mediates sorting of cargo SNARE SNC1 (PubMed:26658609). In contrast to the APM1-containing AP-1 complex, AP-1R is incapable of sorting CHS3 (PubMed:26658609).
messages: Cytoplasm
messages: Endosome
messages: Golgi apparatus
messages: Nucleus
messages: Present with 6370 molecules/cell in log phase SD medium.
messages: clathrin-coated vesicle membrane

559292:YDR210C-C
gene id: 559292:YDR210C-C
uniprot id: Q12441
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR3 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YEL029C
gene id: 559292:YEL029C
uniprot id: P39988
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyridoxine kinase family.
messages: Cytoplasm
messages: Nucleus
messages: Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity). Important for bud site selection.

559292:YGR044C
gene id: 559292:YGR044C
uniprot id: P32338
names: Function
names: Subcellular Location Annotation
messages: Involved in the control of meiosis. Represses the transcription of the IME1 gene thereby inhibiting cells from entering meiosis. But also activates the CLN2 gene thus promoting mitosis.
messages: Nucleus

559292:YLL032C
gene id: 559292:YLL032C
uniprot id: Q07834
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 922 molecules/cell in log phase SD medium.

559292:YAL014C
gene id: 559292:YAL014C
uniprot id: P31377
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syntaxin family.
messages: Endosome membrane
messages: Interacts with PEP12, VTI1 and the SNC SNARE complex proteins.
messages: Palmitoylated by SWF1.
messages: t-SNARE which may play a role in determining the specificity of membrane fusion, protein transport and vesicle trafficking within the Golgi/endosomal and plasma membrane/endosomal systems.

559292:YGR162W
gene id: 559292:YGR162W
uniprot id: P39935
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4G family.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A (TIF1/TIF2), eIF4E (TIF45) and eIF4G (TIF4631 or TIF4632) (By similarity). Interacts with PAT1 in a RNA-dependent manner.
messages: Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus. Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. TIF4631 is probably essential when TIF4632 is missing.
messages: Cytoplasm
messages: P-body
messages: Present with 9760 molecules/cell in log phase SD medium.
messages: Stress granule

559292:YCL030C
gene id: 559292:YCL030C
uniprot id: P00815
names: Cofactor
names: Induction
names: Miscellaneous
names: Similarity
messages: Binds 1 zinc ion.
messages: In the C-terminal section; belongs to the histidinol dehydrogenase family.
messages: Induced by amino acid and purine starvation in a GCN4 dependent manner.
messages: Present with 521 molecules/cell in log phase SD medium.

559292:YOR361C
gene id: 559292:YOR361C
uniprot id: P06103
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Cytoplasm
messages: Present with 47500 molecules/cell in log phase SD medium.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. A subcomplex of TIF32, NIP1 and PRT1 mediates the interaction with eIF-1, TIF5/eIF-5 and HCR1. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.

559292:YGL262W
gene id: 559292:YGL262W
uniprot id: P53054
names: Similarity
messages: To yeast YER187w.

559292:YMR232W
gene id: 559292:YMR232W
uniprot id: Q05670
names: Function
names: Subcellular Location Annotation
messages: Cell tip
messages: Promotes cell fusion during zygote formation.

559292:YER030W
gene id: 559292:YER030W
uniprot id: P40019
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHZ1 family.
messages: Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
messages: Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.
messages: Nucleus
messages: Present with 623 molecules/cell in log phase SD medium.

559292:YER047C
gene id: 559292:YER047C
uniprot id: P39955
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Interacts with SPT2/SIN1.
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YNL269W
gene id: 559292:YNL269W
uniprot id: P53841
names: Miscellaneous
messages: Open reading frame that exhibits genomic organization compatible with a translational readthrough-dependent mode of expression. The sequence can give a readthrough frequency of 9% when cloned in a plasmid with reporter genes. When the initial stop codon is bypassed, translation will go on to the second stop codon 321 bp downstream.
messages: This protein has no orthologs in any species other than the S.cerevisiae lineage. It may be the result of de novo origination of a protein-coding gene.

559292:YDR318W
gene id: 559292:YDR318W
uniprot id: Q06675
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-O/MCM21 family.
messages: Component of the heterotetrameric kinetochore subcomplex COMA, which consists of AME1, CTF19, MCM21 and OKP1 (PubMed:10323865, PubMed:14633972). The COMA subcomplex is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). COMA binds the centromeric nucleosome-binding protein MIF2, and to the outer kinetochore MIND subcomplex (By similarity).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Nucleus
messages: Present with 952 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YCL028W
gene id: 559292:YCL028W
uniprot id: P25367
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 1140 molecules/cell in log phase SD medium.
messages: The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
messages: Transferable epigenetic modifier which forms a prion responsible for the non-Mendelian trait [PIN+]. The native function of the soluble protein is unknown.
messages: [PIN+], also known as [RNQ+], is the prion form of RNQ1 (PubMed:10678178). [PIN+] is the result of a conformational change of the cellular RNQ1 protein that becomes self-propagating and infectious. This conformational change generates a form of RNQ1 that assembles into amyloid fibrils (PubMed:17097676). [PIN+] promotes de novo [PSI+] formation upon SUP35 overproduction (cross-seeding) (PubMed:11511345). [PIN+] can be cured by GdnHCl and by deletion of the molecular chaperone HSP104, which is required for [PIN+] propagation (PubMed:10678178).

559292:YDR470C
gene id: 559292:YDR470C
uniprot id: Q03327
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with FZO1 through its cytoplasmic domain and with MGM1 through its mitochondrial intermembrane space domain.
messages: Mitochondrion outer membrane
messages: Required for mitochondrial fusion as well as normal mitochondrial morphology by bridging the essential interaction between FZO1 and MGM1. May coordinate fusion of inner and outer membranes during mitochondrial fusion.

559292:YMR216C
gene id: 559292:YMR216C
uniprot id: Q03656
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Constitutively active kinase, specifically and sequentially phosphorylates serine/arginine (SR)-type shuttling mRNA binding proteins in their RS dipeptide repeats.
messages: Present with 2420 molecules/cell in log phase SD medium.

559292:YHR018C
gene id: 559292:YHR018C
uniprot id: P04076
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Homotetramer.
messages: Present with 10200 molecules/cell in log phase SD medium.

559292:YDR532C
gene id: 559292:YDR532C
uniprot id: Q04431
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRE28 family.
messages: Component of the SPC105 complex composed of at least SPC105 and KRE28. The SPC105 complex interacts with the MIND and NDC80 complexes at the centromere.
messages: Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.
messages: Nucleus membrane
messages: Present with 377 molecules/cell in log phase SD medium.
messages: kinetochore
messages: spindle pole body

559292:YDL082W
gene id: 559292:YDL082W
uniprot id: Q12690
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL13 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 133000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL13 in yeast.

559292:YDL085C-A
gene id: 559292:YDL085C-A
uniprot id: Q3E7B7
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SERF family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 876 molecules/cell in log phase SD medium.

559292:YCL066W
gene id: 559292:YCL066W
uniprot id: P0CY06
uniprot id: P0CY07
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MATALPHA1 family.
messages: Binds DNA with a high specificity in complex with an MCM1 dimer. Interacts with STE12.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of ALPHA1 at HML.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional coactivator that, in alpha-cells, binds cooperatively with MCM1 and STE12 to a DNA sequence termed the QP' element, to activate the transcription of alpha-specific genes.
messages: Nucleus
messages: Only present in alpha-cells.
messages: Repressed in a/alpha diploid cells by A1/ALPHA2.
messages: There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.

559292:YOR027W
gene id: 559292:YOR027W
uniprot id: P15705
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: By heat shock and canavanine.
messages: Cytoplasm
messages: May play a role in mediating the heat shock response of some HSP70 genes. It is required for optimal growth of yeast cells at both low and high temperature.
messages: N-glycosylated.
messages: Part of a larger complex that includes HSP70, HSP90, and immunophilins.
messages: Present with 67600 molecules/cell in log phase SD medium.

559292:YLR330W
gene id: 559292:YLR330W
uniprot id: Q12114
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes CHS3 localization to the bud neck and plasma membrane, with increased protein localization to intracellular vesicles.
messages: Belongs to the CHS5 family.
messages: Component of the CHS5/6 complex composed of the 4 CHAPS proteins BCH1, BCH2, BUD7, and CHS6 as well as at least CHS5 and GTP-bound ARF1. The complex interacts with the cargo protein CHS3.
messages: Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. Also involved in targeting FUS1 to sites of polarized growth.
messages: Present with 172 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YDL193W
gene id: 559292:YDL193W
uniprot id: Q12063
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Endoplasmic reticulum membrane
messages: Forms an active dehydrodolichyl diphosphate synthase complex with either SRT1 or RER2.
messages: Lipid droplet
messages: Nucleus membrane
messages: With SRT1 or RER2, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).

559292:YBL005W-B
gene id: 559292:YBL005W-B
uniprot id: Q12490
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YBL005W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YPL064C
gene id: 559292:YPL064C
uniprot id: Q02770
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome subcomplex composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (PubMed:11884590).
messages: Present with 2360 molecules/cell in log phase SD medium.

559292:YMR292W
gene id: 559292:YMR292W
uniprot id: Q03554
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: Lack of GOT1 is lethal in a strain lacking SFT2.
messages: Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2.

559292:YML046W
gene id: 559292:YML046W
uniprot id: P39682
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP39 family.
messages: Function prior to stable branch point recognition by the U1 snRNP particle to facilitate or stabilize the U1 snRNP/5'-splice site interaction. Has a direct role in the assembly or function of a catalytically active spliceosome.
messages: Nucleus
messages: Present with 4460 molecules/cell in log phase SD medium.

559292:YHR132C
gene id: 559292:YHR132C
uniprot id: P38836
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Growth rate is increased in lithium chloride (PubMed:33256608). Calcofluor White sensitivity is background dependent (PubMed:9335584, PubMed:33256608).
messages: Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.
messages: Lacks the conserved Glu residue in position 391 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates.
messages: N-glycosylated.
messages: Present with 468 molecules/cell in log phase SD medium.
messages: Secreted
messages: Vacuole

559292:YNR012W
gene id: 559292:YNR012W
uniprot id: P27515
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway.
messages: Cytoplasm
messages: Nucleus

559292:YJL183W
gene id: 559292:YJL183W
uniprot id: P46985
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 34 family.
messages: Component of the M-Pol II complex composed of ANP1, MNN9, MNN10, MNN11 and HOC1.
messages: Present with 3480 molecules/cell in log phase SD medium.
messages: Required for synthesis of full-length mannan chains.
messages: The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.
messages: cis-Golgi network membrane

559292:YPL257W
gene id: 559292:YPL257W
uniprot id: Q08974
names: Function
names: Subcellular Location Annotation
messages: May be required for cell cycle progression.
messages: Membrane

559292:YOL051W
gene id: 559292:YOL051W
uniprot id: P19659
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. It has an important role in the negative regulation of Ty transcription.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules (PubMed:17192271). The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16 (PubMed:17192271). The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins (PubMed:17192271). GAL11/MED15 interacts with the activator GAL4; the interaction is direct (PubMed:11478912). GAL11/MED15 interacts (via multiple regions) with the activator GCN4; the interaction is direct (PubMed:19940160).
messages: Nucleus
messages: Present with 606 molecules/cell in log phase SD medium.
messages: Sensitive to amino acid starvation (PubMed:19940160). Normal GCN4 protein level during amino acid starvation (PubMed:19940160).

559292:YKR043C
gene id: 559292:YKR043C
uniprot id: P36136
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. SHB17 subfamily.
messages: Cytoplasm
messages: Expression is correlated with levels of ribosomal proteins, thus periodic SHB17 expression coincides with the peak demand for ribose phosphate that occurs during ribosome synthesis.
messages: Homodimer.
messages: Nucleus
messages: Present with 11500 molecules/cell in log phase SD medium.
messages: Sedoheptulose 1,7-bisphosphatase involved in riboneogenesis. Dephosphorylates sedoheptulose 1,7-bisphosphate (SBP), which is converted via the non-oxidative pentose phosphate pathway to ribose-5-phosphate. Has a fructose 1,6-bisphosphatase activity in vitro, but this is probably not biologically relevant, since deletion does not affect fructose 1,6-biphosphate (FBP) levels.

559292:YPR013C
gene id: 559292:YPR013C
uniprot id: Q12145
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Leads to altered expression of 79 genes, including genes related to transcription, genes involving cell rescue and defense, and genes involved in cell cycle and DNA processing.
messages: Nucleus
messages: Probable transcription factor involved in the regulation of the transcription of genes involved in cell rescue and defense, as well as cell cycle and DNA processing.

559292:YBL002W
gene id: 559292:YBL002W
uniprot id: P02294
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by GCN5, a component of the SAGA complex, to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1, a component of the NuA4 histone acetyltransferase (HAT) complex. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription.
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitinated by the RAD6/UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation. Deubiquitination is performed by UBP8 in presence of SGF11.
messages: Nucleus
messages: Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation. H2BS10ph is also formed after H(2)O(2) treatment, and is a step leading to apoptosis.
messages: Present with 443000 molecules/cell in log phase SD medium.
messages: Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with NAP1.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BK7ac = acetylated Lys-8; H2BK7su = sumoylated Lys-8; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK16ac = acetylated Lys-17; H2BK16su = sumoylated Lys-17; H2BK17su = sumoylated Lys-18; H2BK123ub1 = monoubiquitinated Lys-124.

559292:YDR140W
gene id: 559292:YDR140W
uniprot id: Q03920
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal PrmC-related family.
messages: Cytoplasm
messages: Heterodimer of MTQ2-TRM112. MTQ2 is the catalytic subunit carrying the catalytic and the S-adenosyl L-methionine binding sites.
messages: Methylates eRF1 on 'Gln-182' using S-adenosyl L-methionine as methyl donor. eRF1 needs to be complexed to eRF3 in its GTP-bound form to be efficiently methylated.
messages: Nucleus
messages: Present with 3390 molecules/cell in log phase SD medium.

559292:YJL181W
gene id: 559292:YJL181W
uniprot id: P46987
names: Similarity
messages: Belongs to the UPF0508 family.

559292:YER114C
gene id: 559292:YER114C
uniprot id: P39969
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Binds to the BEM1 protein. Involved in bud formation.
messages: Present with 688 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YPR042C
gene id: 559292:YPR042C
uniprot id: Q12221
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 377 molecules/cell in log phase SD medium.
messages: RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding membrane-associated proteins with roles in transmembrane transport and vesicular trafficking.

559292:YGR138C
gene id: 559292:YGR138C
uniprot id: P53283
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
messages: By transcription factor HAA1 in response to acetaldehyde accumulation.
messages: Cell membrane
messages: Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermine, but not spermidine.

559292:YLR110C
gene id: 559292:YLR110C
uniprot id: Q12127
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Component of the cell wall. May play a role in the formation of a tightly packed outer mannan layer, which protects the inner glucan.
messages: Extensively O-glycosylated; glycans consist probably of single mannose residues. N-glycosylated.
messages: Membrane
messages: Present with 158000 molecules/cell in log phase SD medium.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: To yeast protein YDR134C.
messages: cell wall

559292:YDR171W
gene id: 559292:YDR171W
uniprot id: Q12329
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: By stress such as heat shock or increased salt concentration. Up-regulated by all stress conditions tested. Also expressed in unstressed cells.
messages: Forms oligomeric complexes. Interacts with itself.
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YOL022C
gene id: 559292:YOL022C
uniprot id: P25040
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSR4 family.
messages: Cytoplasm
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA.

559292:YGL035C
gene id: 559292:YGL035C
uniprot id: P27705
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the creA/MIG C2H2-type zinc-finger protein family.
messages: Involved in glucose repression of the SUC, GAL and MAL genes as well as of the CAT8 gene. Binds to two sites in the upstream region of SUC2.
messages: Nucleus
messages: Present with 830 molecules/cell in log phase SD medium.

559292:YHR047C
gene id: 559292:YHR047C
uniprot id: P37898
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Positive effector of glycogen accumulation. May be involved in nutrient-sensing.
messages: Present with 77000 molecules/cell in log phase SD medium.

559292:YLR074C
gene id: 559292:YLR074C
uniprot id: Q08004
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with pre-60S ribosomal particles; released from the pre-60S particle very early in the cytoplasm.
messages: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:23045392). Involved in positioning the proximal bud pole signal (PubMed:11452010).
messages: Nucleus
messages: Present with 5630 molecules/cell in log phase SD medium.

559292:YDR276C
gene id: 559292:YDR276C
uniprot id: P87284
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Cell membrane
messages: Plays a role in the regulation of membrane potential. Could mediate a proton leak.

559292:YIL091C
gene id: 559292:YIL091C
uniprot id: P40498
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP25 family.
messages: DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
messages: Interacts with snoRNA U3. Interacts with MPP10, NOP19, RRP9, UTP8 and UTP18. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Present with 172 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR196C
gene id: 559292:YDR196C
uniprot id: Q03941
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Endoplasmic reticulum
messages: Lethal.
messages: Mitochondrion
messages: Nucleus
messages: Present with 1660 molecules/cell in log phase SD medium.

559292:YNL309W
gene id: 559292:YNL309W
uniprot id: P42845
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the ANK repeats of SWI6. The interaction with SWI6 is required for function. Interacts with SIN3.
messages: Involved in the regulation and timing of MBF-dependent transcription in late G1 of the cell cycle.
messages: Nucleus
messages: Phosphorylated by CDC28 in a cell cycle-dependent manner, inhibiting the interaction with SWI6.
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YCR020W-B
gene id: 559292:YCR020W-B
uniprot id: Q9URQ5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts directly with RSC8. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Component of a fungal-specific module (HTL1-LDB7-NPL6-RSC3-RSC30) within the RSC complex.
messages: Nucleus
messages: Present with 3550 molecules/cell in log phase SD medium.
messages: Required for cell cycle progression through G2/M transition at temperatures higher than 33 degrees Celsius. Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. When associated with the RSC complex, may act coordinately with PKC1 to regulate G2/M transition. Together with LDB7, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity.

559292:YGL232W
gene id: 559292:YGL232W
uniprot id: P53072
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 2630 molecules/cell in log phase SD medium.
messages: Probable tRNA acetyltransferase required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs. Binds RNA.

559292:YHL002W
gene id: 559292:YHL002W
uniprot id: P38753
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STAM family.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27 (PubMed:12055639). Interacts with the ESCRT-I subunit VPS23, the UBP7 deubiquitinase and the E3 ligase RSP5 (PubMed:17079730, PubMed:15086794). May form a complex composed of VPS27, HSE1 and DOA1 (PubMed:18508771). Interacts (via SH3 domain) with DOA1 (PubMed:18508771).
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
messages: Endosome membrane
messages: Present with 358 molecules/cell in log phase SD medium.

559292:YPL140C
gene id: 559292:YPL140C
uniprot id: P32491
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Present with 1950 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involves the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.

559292:YCR090C
gene id: 559292:YCR090C
uniprot id: P25654
names: Domain
names: Miscellaneous
names: Similarity
messages: Belongs to the UPF0587 family.
messages: Present with 3970 molecules/cell in log phase SD medium.
messages: Requires a bound zinc ion for normal folding and solubility.

559292:YCL050C
gene id: 559292:YCL050C
uniprot id: P16550
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP. Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates with equal efficiency. Cannot catalyze the reverse reaction. Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange reaction between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.
messages: Belongs to the ATP adenylyltransferase family.
messages: Cytoplasm
messages: Inactivation of both APA1 and APA2 promotes a great increase in the cellular concentration of bis(5'-nuceleosidyl) tetraphosphate nucleotides.
messages: Monomer.
messages: Nucleus
messages: Present with 19600 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.

559292:YER165W
gene id: 559292:YER165W
uniprot id: P04147
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, interacts with the nuclear cleavage factor IA (CFIA), which is required for both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. Regulates PAN activity via interaction with the stimulator PAN3 or the inhibitor PBP1. In the cytoplasm, affects both translation and mRNA decay. Stimulates translation by interaction with translation initiation factor eIF4G, a subunit of the cap-binding complex eIF4F, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. Also regulates translation termination by recruiting eukaryotic release factor 3 (eRF3). Interaction with eRF3 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN. Loss of PAB1 from the mRNP after deadenylation triggers mRNA degradation. Inhibits the major cytoplasmic mRNA deadenylase CCR4-NOT complex. Is also associated peripherally with COPI vesicles through its interaction with ARF1, and this is required for correct localization of the asymmetrically distributed ASH1 mRNA.
messages: Binds to poly(A) mRNA to form a periodic structure with a packing density of one molecule per 25 adenylate residues. Interacts with the nuclear export factor CRM1 and with the importin SXM1. Interacts with RNA15, a component of the cleavage factor IA (CFIA) complex. Interacts with translation initiation factor eIF4G (TIF4631 or TIF4632) and release factor eRF3 (SUP35). Interacts with the PAB-dependent poly(A)-nuclease (PAN) complex regulatory subunit PAN3. Interacts with ARF1, DCP1, PBP1, the Hsp70 chaperone SSA1, and TPA1. Interacts with PAT1 in an RNA-dependent manner.
messages: Cytoplasm
messages: Nucleus
messages: Present with 198000 molecules/cell in log phase SD medium.
messages: RNA recognition motifs (RRMs) 1 and 2 bind specifically to the poly(A) tail, whereas RRMs 3 and 4 bind non-specifically to polypyrimidine RNAs and may serve to bind to a different part of the messenger or to other RNAs. RRM 2 also mediates interaction with eIF-4G.

559292:YFR042W
gene id: 559292:YFR042W
uniprot id: P43614
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with KRE6.
messages: Involved in the biosynthesis of (1->6)-beta-D-glucan polymers of the cell wall. Required for viability. Involved in maintaining chromosome stability.

559292:YDR035W
gene id: 559292:YDR035W
uniprot id: P14843
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: By amino acid starvation.
messages: Inhibited by phenyalanine.
messages: Present with 8970 molecules/cell in log phase SD medium.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

559292:YNR049C
gene id: 559292:YNR049C
uniprot id: P53604
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts physically with SEC1.
messages: Involved in secretion. Component of the secretory vesicle docking complex.
messages: Present with 1380 molecules/cell in log phase SD medium.

559292:YER016W
gene id: 559292:YER016W
uniprot id: P40013
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: Binds microtubules.
messages: Present with 3630 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YIL082W-A
gene id: 559292:YIL082W-A
uniprot id: Q7LHG5
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the genomic RNA-nucleocapsid complex.
messages: Cytoplasm
messages: In contrast to Ty3-1 (Ty3-G), Ty3-2 (Ty3-I) is a transpositionally inactive element. The Ty3-2 ORF is truncated by the deletion of a single nucleotide, which causes a frameshift mutation when compared with Ty3-1.
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleocapsid protein p11 (NC) forms the nucleocore that coats the retro-elements dimeric RNA. Binds these RNAs through its zinc fingers (By similarity). Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Ala-285 and Val-286 of the YIL082W ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty3 retrotransposons belong to the gypsy-like elements (metaviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The protease is a homodimer, whose active site consists of two apposed aspartic acid residues.

559292:YLR278C
gene id: 559292:YLR278C
uniprot id: Q05854
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 1080 molecules/cell in log phase SD medium.

559292:YER082C
gene id: 559292:YER082C
uniprot id: P40055
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: Present with 5800 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YOL075C
gene id: 559292:YOL075C
uniprot id: Q08234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

559292:YFL021W
gene id: 559292:YFL021W
uniprot id: P43574
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Positive regulator of multiple nitrogen catabolic genes.
messages: Present with 1180 molecules/cell in log phase SD medium.

559292:YLR265C
gene id: 559292:YLR265C
uniprot id: Q06148
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Cytoplasm
messages: Involved in non-homologous end joining (NHEJ). Facilitates the transport of LIF1 into the nucleus, where it can interact with DNA ligase DNL4 to repair double-strand breaks (DSB). Mediates mating-type regulation of NHEJ. Prevents chromosome circularisation by NHEJ in absence of telomerase.
messages: Nucleus membrane
messages: Present with 377 molecules/cell in log phase SD medium.
messages: Repressed in diploid cells.

559292:YOL061W
gene id: 559292:YOL061W
uniprot id: Q12265
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Cytoplasm
messages: Present with 3310 molecules/cell in log phase SD medium.

559292:YOR352W
gene id: 559292:YOR352W
uniprot id: Q08816
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 3510 molecules/cell in log phase SD medium.

559292:YKL084W
gene id: 559292:YKL084W
uniprot id: P36078
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the small Tim proteins TIM8, TIM9, TIM10, TIM12, and TIM13.
messages: Mitochondrion intermembrane space
messages: Mitochondrion membrane
messages: Required for the assembly or recycling of the small Tim proteins in the mitochondrial intermembrane, thereby participating in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Probably acts by facilitating the formation of disulfide bonds in small Tim proteins.

559292:YGR275W
gene id: 559292:YGR275W
uniprot id: P53330
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with STH1 and SWI3. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Probable additional component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Nucleus
messages: Present with 1550 molecules/cell in log phase SD medium.
messages: Probable component of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Probable component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

559292:YOL021C
gene id: 559292:YOL021C
uniprot id: Q08162
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. DIS3 has both 3'-5' exonuclease and endonuclease activities. The exonuclease activity of DIS3 is down-regulated upon association with Exo-9 possibly involving a conformational change in the catalytic domain and threading of the RNA substrate through the complex central channel. Structured substrates can be degraded if they have a 3' single-stranded extension sufficiently long (such as 35 nt poly(A)) to span the proposed complex inner RNA-binding path and to reach the exonuclease site provided by DIS3. Plays a role in mitotic control.
messages: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure. DIS3 associates at the respective bottom side with Exo-9. Interacts with GSP1.
messages: Cytoplasm
messages: It was originally thought that there are multiple subunits in the exosome that have exonuclease activity but it was later shown (PubMed:17173052 and PubMed:17174896) that only this DIS3/RRP44 subunit of the exosome core has this activity.
messages: Mitochondrion
messages: Mn(2+) doesn't support the hydrolytic activity. Activity is KCl or NaCl dependent and activity is slightly increased in the presence of reducing agents such as DTT or beta-mercaptoethanol and doesn't vary notably between pH 6.8 and 8.8.
messages: Present with 606 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR139C
gene id: 559292:YLR139C
uniprot id: P42900
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLS1 family.
messages: Involved in aerobic respiration where it is required for assembly of respiratory chain enzyme complexes III and IV. Also has a role in mitochondrial gene expression. May be part of a mitochondrial membrane-associated RNA-shuttling system, delivering NAM1-associated transcripts to the translation machinery.
messages: Mitochondrion inner membrane
messages: Present with 3430 molecules/cell in log phase SD medium.

559292:YOR319W
gene id: 559292:YOR319W
uniprot id: Q99181
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with RDS3.
messages: Nucleus
messages: Possible SF3b-like factor.
messages: Present with 1240 molecules/cell in log phase SD medium.

559292:YER062C
gene id: 559292:YER062C
uniprot id: P40106
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.
messages: By osmotic stress (at protein level).
messages: Cytoplasm
messages: Glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis. Plays a role in osmoadaptation.
messages: Monomer.
messages: Nucleus
messages: Present with 5000 molecules/cell in log phase SD medium.

559292:YNL006W
gene id: 559292:YNL006W
uniprot id: P41318
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cell membrane
messages: Essential component of both TORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. LST8 is involved in the negative regulation of transcription factors GLN3 and RTG1-RTG3, limiting the synthesis of alpha-ketoglutarate, glutamate and glutamine. LST8 is required for targeting of amino acid permeases (AAPs) to the plasma membrane. TORC2 regulates cell cycle-dependent polarization of the actin-cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. LST8 is involved in maintenance of cell wall integrity. LST8 modulates TOR2 kinase activity.
messages: Present with 589 molecules/cell in log phase SD medium.
messages: The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B) (PubMed:12408816, PubMed:12631735, PubMed:12719473). TORC1 binds to and is inhibited by FKBP-rapamycin (PubMed:12408816). Interacts with PIB2; following activation of PIB2 by glutamine or cysteine and as part of the TORC1 complex (PubMed:29698392). The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11 (PubMed:12408816, PubMed:12631735, PubMed:12719473). TORC2 likely forms a homodimer (PubMed:16002396). Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin (PubMed:12408816). LST8 binds to the C-terminal kinase domain in TOR2 (PubMed:16002396).
messages: Vacuole membrane

559292:YDR185C
gene id: 559292:YDR185C
uniprot id: Q04006
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the slowmo family.
messages: Interacts with MDM35.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Present with 672 molecules/cell in log phase SD medium.
messages: Required for mitochondrial morphology. With UPS1 and UPS2, controls phospholipid metabolism in the mitochondrial intermembrane space.

559292:YBL035C
gene id: 559292:YBL035C
uniprot id: P38121
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A POL1 and B POL12, and the DNA primase large PRI2 and small PRI1 subunits (PubMed:3061469). Subunit B POL12 binds to subunit A POL1 (PubMed:19494830).
messages: Non-catalytic component of DNA polymerase alpha, which in a complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase. POL12 may play an essential role at the early stage of chromosomal DNA replication by coupling DNA polymerase alpha to the cellular replication machinery (By similarity). Interacts with MCM10.
messages: Nucleus
messages: Phosphorylated in a cell cycle-dependent manner.
messages: Present with 11200 molecules/cell in log phase SD medium.

559292:YHL008C
gene id: 559292:YHL008C
uniprot id: P38750
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

559292:YDR512C
gene id: 559292:YDR512C
uniprot id: Q04406
names: Function
names: Similarity
messages: Belongs to the EMI1 family.
messages: Involved in sporulation. Required for the full activation of the early meiotic inducer IME1.

559292:YMR301C
gene id: 559292:YMR301C
uniprot id: P40416
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Homodimer.
messages: Impairs cytosolic iron-sulfur (Fe-S) cluster assembly and decreases cytosolic tRNA thiolation.
messages: Mitochondrion inner membrane
messages: Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (PubMed:10406803, PubMed:31040179, PubMed:25006243). Hydrolyzes ATP (PubMed:25006243, PubMed:24604199). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (PubMed:24604199, PubMed:25006243, PubMed:31040179).
messages: Present with 3250 molecules/cell in log phase SD medium.

559292:YOR110W
gene id: 559292:YOR110W
uniprot id: Q12415
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker.
messages: Nucleus
messages: Present with 2660 molecules/cell in log phase SD medium.
messages: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes.

559292:YDL014W
gene id: 559292:YDL014W
uniprot id: P15646
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain SNU13, NOP1, SIK1/NOP56 and NOP58, plus a guide RNA. Interacts with snoRNA U3. Interacts with MPP10, NOP58, SIK1 and SOF1. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Methylated by HMT1, forming asymmetric dimethylarginines (DMA) within a domain referred to as an RGG box, made up of repeated Gly-Gly dipeptides interspersed with Arg and aromatic residues.
messages: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:2686980, PubMed:1825809, PubMed:12215523). Site specificity is provided by a guide RNA that base pairs with the substrate (PubMed:2686980, PubMed:1825809). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (PubMed:2686980, PubMed:1825809). Involved in the biogenesis of the 18S rRNA (PubMed:2686980, PubMed:1825809). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).
messages: nucleolus

559292:YOR241W
gene id: 559292:YOR241W
uniprot id: Q08645
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Required for methionine synthesis and maintenance of intact mitochondrial DNA. Involved in telomere maintenance.
messages: Cytoplasm
messages: Methionine auxotroph. Undetectable levels of folylpolyglutamate synthase activity. Increased rate of loss of mitochondrial DNA. Respiration-deficient. MET7 and FOL3 double mutant cells are not viable even in the presence of methionine and folinic acid. MET7, FOL3 and TUP1 triple disruption mutant is able to germinate on YPGA medium containing thymidylate and to grow although poorly on synthetic medium containing methionine, adenine and thymidylate. Adenine and thymidine auxotroph when grown in the presence of sulfanilamide. Becomes petite under normal growth conditions but can be maintained with a grande phenotype if the strain is TUP1 and all media are supplemented with dTMP. MET7 and GLY1 double mutant is auxotrophic for glycine when grown on glucose but prototrophic when grown on glycerol. MET7 and SER1 double mutant cannot use glycine to suppress serine auxotrophy. MET7 and SHM2 double mutant is nonviable.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Present with 7080 molecules/cell in log phase SD medium.

559292:YDR119W-A
gene id: 559292:YDR119W-A
uniprot id: Q2V2P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal cytochrome c oxidase subunit 26 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

559292:YDR057W
gene id: 559292:YDR057W
uniprot id: Q99220
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum membrane
messages: Homodimer (PubMed:22262864). Component of the HRD1 ubiquitin ligase complex which contains the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and CDC48-binding protein UBX2 (PubMed:16873065, PubMed:16873066). Within the complex, interacts (via N-terminus) with HRD3 (PubMed:22262864). In ERAD-L, HRD3 and YOS9 jointly bind misfolded glycoproteins in the endoplasmic reticulum (ER) lumen (PubMed:32327568). Movement of ERAD-L substrates through the ER membrane is facilitated by HRD1 and DER1 which have lateral gates facing each other and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568). The HRD1 complex interacts with the heterotrimeric CDC48-NPL4-UFD1 ATPase complex which is recruited by UBX2 via its interaction with CDC48 and which moves ubiquitinated substrates to the cytosol for targeting to the proteasome (PubMed:16873065, PubMed:16873066). Interacts with KAR2 and EMP47 (PubMed:16873065). Interacts with misfolded ER lumenal proteins like PCR1 (PubMed:16168370, PubMed:16168371, PubMed:16168372). Interacts with the GPI-anchored proteins GAS1 and MKC7 (PubMed:12077121).
messages: Interaction of substrate with HRD1 is reduced; in YOS9 and USA1 double mutants this interaction is completely abolished. Interaction of substrate (either glycosylated or non-glycosylated) with HRD3 is not affected.
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. The recognition of targets is N-glycan specific. Functions in recruiting misfolded protein substrates in conjunction with HRD3 (PubMed:32327568).
messages: The MRH (mannose 6-phosphate receptor homology) domain is required for the ERAD-L activity.

559292:YJL113W
gene id: 559292:YJL113W
uniprot id: P47024
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-363 and Gly-364 of the YJL114W ORF.
messages: Proteolytically processed into capsid protein (CA), Ty4 protease (PR), integrase (IN) and reverse transcriptase/ribonuclease H (RT) proteins (Probable). Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty4 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The protease is a homodimer, whose active site consists of two apposed aspartic acid residues.

559292:YPR133W-A
gene id: 559292:YPR133W-A
uniprot id: P80967
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom5 family.
messages: Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.
messages: Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70).
messages: Mitochondrion outer membrane

559292:YHL013C
gene id: 559292:YHL013C
uniprot id: P38747
names: Miscellaneous
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YDR164C
gene id: 559292:YDR164C
uniprot id: P30619
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Interacts with MSO1.
messages: Involved in the final stage of protein secretion.
messages: Present with 639 molecules/cell in log phase SD medium.

559292:YCL067C
gene id: 559292:YCL067C
uniprot id: P0CY08
uniprot id: P0CY09
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TALE/M-ATYP homeobox family.
messages: Binds DNA with a high specificity as a heterotetramer consisting of an ALPHA2 dimer and an MCM1 dimer. Also binds DNA with a high specificity as a heterodimer of A1 and ALPHA2 in a/alpha diploid cells. Interacts with the general transcription repressor complex SSN6/TUP1.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of ALPHA2 at HML.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that binds cooperatively with MCM1 to a 31-basepair DNA sequence termed the a-specific gene (asg) operator, to repress the transcription of a-cell-specific genes. Additionally, in a/alpha diploid cells, binds cooperatively with the A1 protein to a 21-basepair DNA sequence termed the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1.
messages: Nucleus
messages: Only present in alpha-cells and in a/alpha diploid cells.
messages: The C-terminal tail domain is disordered in the monomer, even when bound to DNA. In the ternary complex with A1 and DNA, 16 residues (Ile-190 to Leu-205) of the C-terminal tail undergo a conformational change, becoming ordered and contacting the A1 homeodomain.
messages: The N-terminal domain is required for the interaction with the WD repeats of TUP1 and for dimerization.
messages: The homeobox domain binds to DNA and interacts with the TPR repeats of SSN6.
messages: The unstructured, flexible linker domain contains eight residues (Leu-114 to Gln-121), which, in the presence of MCM1, adopt a beta-fold and mediate the cooperative interaction to MCM1.
messages: There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.

559292:YDR034C-C
gene id: 559292:YDR034C-C
uniprot id: Q12392
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YLR261C
gene id: 559292:YLR261C
uniprot id: O13549
names: Disruption Phenotype
messages: Deletion causes a vacuolar protein sorting defect.

559292:YBL059C-A
gene id: 559292:YBL059C-A
uniprot id: Q3E7A4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CMC family.
messages: Interacts with CMC1.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Present with 279 molecules/cell in log phase SD medium.
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. May be involved in copper trafficking and distribution to mitochondrial COX and SOD1.
messages: The twin Cx9C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.

559292:YJL201W
gene id: 559292:YJL201W
uniprot id: P32525
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in cell wall organization and biogenesis.
messages: Present with 1750 molecules/cell in log phase SD medium.

559292:YMR194W
gene id: 559292:YMR194W
uniprot id: P05745
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 31600 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL36 in yeast.

559292:YLR095C
gene id: 559292:YLR095C
uniprot id: Q12072
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ISW1B complex, which at least consists of ISW1, IOC2 and IOC4.
messages: Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.
messages: Nucleus
messages: Present with 7520 molecules/cell in log phase SD medium.

559292:YJR088C
gene id: 559292:YJR088C
uniprot id: P47133
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
messages: Present with 5740 molecules/cell in log phase SD medium.

559292:YHR200W
gene id: 559292:YHR200W
uniprot id: P38886
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S5A family.
messages: Cells are viable.
messages: Multiubiquitin binding protein.
messages: Present with 17200 molecules/cell in log phase SD medium.
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC) (PubMed:12504901, PubMed:8887631, PubMed:22927375). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (PubMed:22927375).
messages: Ubiquitinated, leading to its degradation (PubMed:17190603). Ubiquitination is promoted by HUL5 (PubMed:17190603).

559292:YOR194C
gene id: 559292:YOR194C
uniprot id: P32773
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 1 family.
messages: Cytoplasm
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein).
messages: TFIIA is a heterodimer composed of the large TOA1 and a small TOA2 subunits. Interacts with KAP122.

559292:YAL056W
gene id: 559292:YAL056W
uniprot id: P39717
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Beta subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth.
messages: Cytoplasm
messages: G proteins are composed of 3 units, alpha, beta and gamma. GPB1 interacts with the alpha subunit GPA2.
messages: Mitochondrion

559292:YBR149W
gene id: 559292:YBR149W
uniprot id: P38115
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the oxidation of D-arabinose, L-xylose, L-fucose and L-galactose in the presence of NADP(+).
messages: Cytoplasm
messages: Heterodimer of a heavy chain and a light chain.
messages: Present with 30200 molecules/cell in log phase SD medium.

559292:YBL029C-A
gene id: 559292:YBL029C-A
uniprot id: Q3E756
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0768 family.
messages: Cell membrane
messages: Present with 996 molecules/cell in log phase SD medium.

559292:YNL300W
gene id: 559292:YNL300W
uniprot id: P48560
names: Disruption Phenotype
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOS6 family.
messages: Expression decreases in response to ergosterol perturbation or upon entry into stationary phase.
messages: Increases resistance to lactic acid.
messages: Membrane
messages: Present with 1480 molecules/cell in log phase SD medium.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

559292:YKL132C
gene id: 559292:YKL132C
uniprot id: P36001
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folylpolyglutamate synthase family.
messages: Conversion of folates to polyglutamate derivatives.
messages: Mitochondrion

559292:YLR353W
gene id: 559292:YLR353W
uniprot id: P41698
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be involved in positioning the distal bud pole signal.
messages: N- and O-glycosylated.
messages: To yeast BUD9.

559292:YNR069C
gene id: 559292:YNR069C
uniprot id: P53755
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the BUL1 family.
messages: May be a component of the ubiquitination pathway.
messages: Open reading frame exhibits genomic organization compatible with a translational readthrough-dependent mode of expression.

559292:YIL041W
gene id: 559292:YIL041W
uniprot id: P40531
names: Miscellaneous
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Present with 7721 molecules/cell in log phase SD medium.

559292:YJL095W
gene id: 559292:YJL095W
uniprot id: Q01389
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Present with 112 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act on this kinase. BCK1 probably phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.

559292:YGR224W
gene id: 559292:YGR224W
uniprot id: P50080
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Transcriptionally regulated by PDR8.
messages: Transporter protein required for adaptation to high stress imposed by low-chain organic acids, in particular by acetic acid, and for resistance to azoles, especially to ketoconazole and fluconazole.

559292:YJR009C
gene id: 559292:YJR009C
uniprot id: P00358
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Present with 121000 molecules/cell in log phase SD medium.
messages: There are three genes for G3PDH in yeast.

559292:YOR226C
gene id: 559292:YOR226C
uniprot id: Q12056
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NifU family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Cells deleted for both ISU1 and ISU2 have decreased activity of several respiratory enzymes that contain Fe-S clusters. As a result, cells grow poorly on carbon sources requiring respiration and also accumulate abnormally high levels of iron in their mitochondria. Knockdown of ISU1 in ISU2 knockout cells decreases cytosolic tRNA thiolation, and increases association between SSQ1 and GRX5 (PubMed:31040179, PubMed:23615440).
messages: Component of the core Fe-S cluster (ISC) assembly machinery. Interacts with frataxin (By similarity). Interacts with the mitochondrial co-chaperones JAC1 and SSQ1 (By similarity). Interacts with NFS1 (By similarity). Interacts with ferredoxin YAH1; interacts with the reduced form (By similarity).
messages: Mitochondrion matrix
messages: Present with 3420 molecules/cell in log phase SD medium.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2. In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH. Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1 (PubMed:23615440). ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (By similarity). ISU2 is the minor isoform in yeast and is not detectable in cells grown to stationary phase (PubMed:10588895). Also involved in production of a sulfur precursor required for thiolation of cytoplasmic tRNAs (PubMed:31040179).

559292:YBL046W
gene id: 559292:YBL046W
uniprot id: P38193
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Nucleus
messages: Present with 1010 molecules/cell in log phase SD medium.
messages: Regulatory subunit (R2) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4. Interacts with SPT4 and SPT5.
messages: Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.

559292:YBL041W
gene id: 559292:YBL041W
uniprot id: P23724
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

559292:YPL168W
gene id: 559292:YPL168W
uniprot id: Q12467
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: During M phase of cell cycle.
messages: Mitochondrion
messages: Mitochondrion membrane

559292:YMR282C
gene id: 559292:YMR282C
uniprot id: P22136
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AEP2 family.
messages: Binds to the 5'UTR of the OLI1 mRNA.
messages: Mitochondrion
messages: Present with 2680 molecules/cell in log phase SD medium.
messages: Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.

559292:YOR069W
gene id: 559292:YOR069W
uniprot id: Q92331
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPSD5 and VPS17.
messages: Cytoplasm
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Phosphorylated on serine residue(s).
messages: Plays a role in vesicular protein sorting. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.
messages: Present with 6120 molecules/cell in log phase SD medium.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

559292:YDL247W
gene id: 559292:YDL247W
uniprot id: P0CD99
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: By maltose and maltotriose. Repressed by glucose.
messages: Cell membrane
messages: High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose.

559292:YIR012W
gene id: 559292:YIR012W
uniprot id: P35184
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts strongly with QSR1. Part of an oligomeric protein complex that is loosely associated with ribosomes.
messages: May be involved in the late step of 60S ribosomal subunit assembly or modification in the cytoplasm.
messages: Present with 19700 molecules/cell in log phase SD medium.

559292:YLR306W
gene id: 559292:YLR306W
uniprot id: P52491
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins. The major substrate is CDC53/Cullin.
messages: Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
messages: Interacts with DCN1.
messages: The acetylation of Met-1 is cotranslational, and not regulatory. The N-acetylmethionine increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.

559292:YGL070C
gene id: 559292:YGL070C
uniprot id: P27999
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation. Involved in DNA repair of damage in the transcribed strand. Mediates a transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER).
messages: Present with 2440 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YPL069C
gene id: 559292:YPL069C
uniprot id: Q12051
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.
messages: Cytoplasm
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YCR037C
gene id: 559292:YCR037C
uniprot id: P25360
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Involved in the uptake of inorganic phosphate.
messages: Membrane
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YJL002C
gene id: 559292:YJL002C
uniprot id: P41543
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:8175708, PubMed:16297388, PubMed:16096345, PubMed:15831493, PubMed:15886282, PubMed:9405463, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962). Interacts with SEC61, SBH1 and SSS1 (PubMed:15831493).
messages: Endoplasmic reticulum membrane
messages: Present with 11900 molecules/cell in log phase SD medium.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

559292:YEL002C
gene id: 559292:YEL002C
uniprot id: P33767
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:8175708, PubMed:16297388, PubMed:16096345, PubMed:15831493, PubMed:15886282, PubMed:9405463, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962). Interacts with SEC61, SBH1 and SSS1 (PubMed:15831493).
messages: Endoplasmic reticulum membrane
messages: Present with 14900 molecules/cell in log phase SD medium.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

559292:YIR021W
gene id: 559292:YIR021W
uniprot id: P07266
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Function in mitochondrial RNA splicing in the excision of mitochondrial group I introns aI5 beta from COX1 and bI3 from COB transcripts and thus would be involved in obtaining the correct structure of the intron, to allow the RNA catalyzed reactions to occur.
messages: Homodimer. Forms a ribonucleoprotein complex composed of maturase bI3 and 2 dimers of MRS1 that assemble around the bI3 RNA.
messages: Mitochondrion matrix
messages: Present with 5240 molecules/cell in log phase SD medium.

559292:YOL124C
gene id: 559292:YOL124C
uniprot id: Q12463
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Cytoplasm
messages: Interacts with TRM112.
messages: Present with 2020 molecules/cell in log phase SD medium.

559292:YHL007C
gene id: 559292:YHL007C
uniprot id: Q03497
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated and phosphorylated by the CLN2-CDC28 complex in a cell cycle dependent manner.
messages: Autophosphorylated on serine residues.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Interacts with BEM1, CDC42, CLN2, STE4 and the 14-3-3 proteins BMH1 and BMH2.
messages: MAP4K component of the MAPK pathway required for the mating pheromone response, haploid invasive growth and diploid pseudohyphal development. Links the pheromone response G-protein beta gamma subunits to downstream signaling components. Needed for mating in haploid cells, induction of a mating-specific gene FUS1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest. Required for the regulation of the actin polarization and bud emergence during cell cycle in G1. Involved in the high osmolarity glycerol (HOG) response. Phosphorylates 'Thr-307' and 'Ser-302' or 'Ser-306' of STE11 and 'Ser-357' of MYO3. Phosphorylates histone H2B to form H2BS10ph during meiosis and H(2)O(2)-induced apoptosis. Its interaction with CDC42 is required for both invasive growth and the formation of pseudohyphae. Its interaction with STE4 is required for the pheromone signaling.
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.
messages: The CRIB domain is required for the association with CDC42.

559292:YKL176C
gene id: 559292:YKL176C
uniprot id: P34239
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the LST4 family.
messages: Involved in extracellular amino acid uptake. Required for the trafficking of the GAP1 nitrogen-regulated general amino acid permease from the Golgi to the plasma membrane.
messages: Sensitive to high hydrostatic pressure (mechanical stress).

559292:YLR241W
gene id: 559292:YLR241W
uniprot id: Q06538
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by hyperosmotic shock after mannitol treatment.
messages: Acts as an osmosensitive calcium-permeable cation channel.
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

559292:YPL256C
gene id: 559292:YPL256C
uniprot id: P20438
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
messages: A dominant mutation in CLN2 gene (CLN2-1), advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals.
messages: Belongs to the cyclin family.
messages: CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.
messages: Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YOL084W
gene id: 559292:YOL084W
uniprot id: Q12252
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an osmosensitive calcium-permeable cation channel.
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Cell membrane
messages: Regulated by phosphate levels.

559292:YNL090W
gene id: 559292:YNL090W
uniprot id: P06781
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Interacts with BEM4.
messages: Present with 3870 molecules/cell in log phase SD medium.

559292:YPR134W
gene id: 559292:YPR134W
uniprot id: P08593
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Involved in splicing of intron aI5-beta of the mitochondrial COX1 transcript.
messages: Mitochondrion
messages: Present with 861 molecules/cell in log phase SD medium.
messages: To baculovirus occlusion-derived virus envelope protein E27 (ODV-E27).

559292:YJL019W
gene id: 559292:YJL019W
uniprot id: P47069
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the linker nucleocytoskeleton and cytoskeleton (LINC) complex composed of at least MPS2, MPS3 and CSM4 (PubMed:32967926). Interacts with HTZ1 (PubMed:21518795). Interacts with REC8 (PubMed:30417519). Interacts with CSM4; ECO1, EST1, JEM1, CDC31, NDJ1, MPS2 and SIR4 (PubMed:12486115, PubMed:12493774, PubMed:15355977, PubMed:16923827, PubMed:17245108, PubMed:17495028, PubMed:18039933, PubMed:18585352).
messages: Component of the linker nucleocytoskeleton and cytoskeleton (LINC) complex that regulates telomere movement and meiotic recombination during meiosis (PubMed:17245108, PubMed:18585352, PubMed:32967926). Connects the spindle pole body with the nuclear envelope through its interaction with MPS2 and mediates meiotic bouquet formation and rapid chromosome movements in meiotic prophase (PubMed:16923827, PubMed:17495028, PubMed:22017544). Functions as an integral membrane anchor for telomeres and is a nuclear receptor for the SIR4 pathway of telomere tethering and gene inactivation (PubMed:18039933, PubMed:19390087). Essential for nuclear division and fusion and required for the first step of spindle pole body duplication in G1 (PubMed:12486115, PubMed:12493774). Functions in sister chromatid cohesion establishment (PubMed:15355977, PubMed:16682351). Recruits double-strand breaks (DSBs) to the nuclear periphery for chromosome healing (PubMed:19390086, PubMed:19217407, PubMed:20016273).
messages: Nucleus inner membrane
messages: Phosphorylation at Ser-189 and Ser-190 by CDC7 and CDC28 during meiosis regulates of the localization on nuclear envelope for meiotic chromosome motion and nuclear envelope remodeling.
messages: The SUN domain is involved in the binding to MPS2 and is important for modulating chromosome motion events that act in meiotic chromosome juxtaposition and by extension, promoting proper morphogenesis of the synaptonemal complex.
messages: spindle pole body
messages: telomere

559292:YNL025C
gene id: 559292:YNL025C
uniprot id: P47821
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the SRB8-11 complex which consists of SRB8, SSN2/SRB9, SSN3/SRB10 and SSN8/SRB11. The SRB8-11 complex associates with the Mediator complex. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair also associate with the RNA polymerase II holoenzyme. Interacts with ASK10.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions.
messages: Nucleus

559292:YCR063W
gene id: 559292:YCR063W
uniprot id: P25337
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUD31 (G10) family.
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Involved in pre-mRNA splicing. Important for bud site selection.
messages: Nucleus
messages: Present with 1900 molecules/cell in log phase SD medium.

559292:YGR046W
gene id: 559292:YGR046W
uniprot id: P53230
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
messages: Deficient in cardiolipin. Blocked in the import of presequence-containing proteins as well as of non-cleavable carrier proteins into mitochondria.
messages: Magnesium. Also active with cobalt or copper.
messages: Mitochondrion inner membrane
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Was initially identified as protein involved in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane by its role in maintaining the integrity and stability of the inner membrane translocase TIM23 complex (PubMed:16943180, PubMed:16790493). It has later been shown that this phenotype can be attributed to the pleiotropic effects of mitochondria lacking cardiolipin (PubMed:19114592).

559292:YPL151C
gene id: 559292:YPL151C
uniprot id: Q12417
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome subcomplex composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with CEF1, CLF1, NTC20, PRP45 and SYF1.
messages: Belongs to the WD repeat PRL1/PRL2 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. May also be required for cell cycle progression at G2/M (By similarity).
messages: Nucleus
messages: Present with 1770 molecules/cell in log phase SD medium.

559292:YPR147C
gene id: 559292:YPR147C
uniprot id: Q06522
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Accumulates lipid droplets.
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet
messages: Membrane
messages: Present with 2190 molecules/cell in log phase SD medium.
messages: Shows both triacylglycerol (TAG) lipase and ester hydrolase activities. May play a role in TAG homeostasis.

559292:YFR022W
gene id: 559292:YFR022W
uniprot id: P43602
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the arrestin family.
messages: Interacts with RSP5 via its 2 PY-motifs.
messages: Involved in resistance to GST substrate o-dinitrobenzene (o-DNB).
messages: The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase.

559292:YBR091C
gene id: 559292:YBR091C
uniprot id: P32830
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54, associated with the peripheral proteins MRS5/TIM12 and the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13). Interacts directly with both the TIM22 protein and the TIM9-TIM10 heterohexamer. Interacts with multi-pass transmembrane proteins in transit.
messages: Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. In the TIM22 complex, it acts as a docking point for the soluble TIM9-TIM10 heterohexamer that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM12 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

559292:YMR099C
gene id: 559292:YMR099C
uniprot id: Q03161
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.
messages: Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).
messages: Present with 8580 molecules/cell in log phase SD medium.

559292:YMR156C
gene id: 559292:YMR156C
uniprot id: Q03796
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA 3' phosphatase family.
messages: Dephosphorylate DNA's 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA.
messages: Nucleus

559292:YBR063C
gene id: 559292:YBR063C
uniprot id: P38083
names: Subcellular Location Annotation
messages: Membrane

559292:YJL043W
gene id: 559292:YJL043W
uniprot id: P47053
names: Similarity
messages: To yeast YKR015c.

559292:YIL117C
gene id: 559292:YIL117C
uniprot id: P40476
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM5 family.
messages: Expression is regulated by the cell integrity signaling pathway and by pheromone.
messages: Membrane

559292:YHR164C
gene id: 559292:YHR164C
uniprot id: P38859
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Chromosome
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is atypical: it cannot load onto its tracking strand internally and has an absolute free 5'-end requirement. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
messages: Nucleus
messages: Phosphorylated at Ser-17 and Ser-237 by CDK1 in response to DNA damage, leading to promote recruitment to double-strand break (DSB) sites and DNA resection.

559292:YNR064C
gene id: 559292:YNR064C
uniprot id: P53750
names: Similarity
messages: Belongs to the DmpD/TodF/XylF esterase family.

559292:YNL139C
gene id: 559292:YNL139C
uniprot id: P53552
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of HPR1, MFT1, THO2 and THP2. Together with SUB2, TEX1 and YRA1, THO forms the transcription/export (TREX) complex. THO associates with DNA and RNA in vitro.
messages: Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
messages: Nucleus
messages: Present with 521 molecules/cell in log phase SD medium.

559292:YDR386W
gene id: 559292:YDR386W
uniprot id: Q04149
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with MMS4 and RAD54.
messages: Interacts with MMS4 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions. Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures. May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover. In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved. Spore formation and viability are severely impaired in deletion strains.
messages: Nucleus
messages: Present with 300 molecules/cell in log phase SD medium.
messages: Two distinct classes of meiotic crossovers have been demonstrated in budding yeast. Class I crossovers exhibit crossover interference and require MSH4 and MSH5 for their resolution, while class II crossovers exhibit no crossover interference and require MUS81 and MMS4. While class I crossovers represent the majority of crossovers in S.cerevisiae, they are virtually absent in S.pombe, which lacks orthologs of MSH4 and MSH5.

559292:YOR232W
gene id: 559292:YOR232W
uniprot id: P38523
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Component of the PAM complex, at least composed of SSC1 (mtHsp70), MGE1, TIM44, PAM16/TIM16, PAM17 and PAM18/TIM14. Interacts with SSQ1.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins and the association of SSC1 with TIM44.
messages: Mitochondrion matrix
messages: The N-terminus is blocked.

559292:YDR210W-A
gene id: 559292:YDR210W-A
uniprot id: Q03483
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YDR317W
gene id: 559292:YDR317W
uniprot id: Q06674
names: Function
messages: May participate in the control of processing of mutational intermediates appearing during error-prone bypass of DNA damage.

559292:YJL052W
gene id: 559292:YJL052W
uniprot id: P00360
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Present with 120000 molecules/cell in log phase SD medium.
messages: There are three genes for G3PDH in yeast.

559292:YBR130C
gene id: 559292:YBR130C
uniprot id: P38272
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE3 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SHE2 and MYO4.
messages: Present with 1010 molecules/cell in log phase SD medium.
messages: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud.

559292:YFR030W
gene id: 559292:YFR030W
uniprot id: P39692
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.
messages: By methionine deprivation.
messages: Present with 1580 molecules/cell in log phase SD medium.
messages: This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

559292:YLR185W
gene id: 559292:YLR185W
uniprot id: P49166
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 21800 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL37 in yeast.

559292:YNR015W
gene id: 559292:YNR015W
uniprot id: P53720
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dus family. Dus2 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:12003496, PubMed:14970222). Specifically modifies U20 in cytoplasmic tRNAs (PubMed:12003496, PubMed:14970222). Also able to mediate dihydrouridylation of some mRNAs, thereby affecting their translation (By similarity).
messages: Cytoplasm
messages: Monomer.
messages: N-glycosylated.
messages: Nucleus
messages: Present with 2650 molecules/cell in log phase SD medium.

559292:YDR412W
gene id: 559292:YDR412W
uniprot id: Q04031
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: Essential protein involved in ribosomal RNA processing.
messages: Present with 2950 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDL182W
gene id: 559292:YDL182W
uniprot id: P48570
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
messages: Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.
messages: Cytoplasm
messages: Present with 28100 molecules/cell in log phase SD medium.

559292:YJL177W
gene id: 559292:YJL177W
uniprot id: P46990
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL22 is associated with the polypeptide exit tunnel (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 21100 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL22 in yeast.

559292:YML025C
gene id: 559292:YML025C
uniprot id: P51998
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YBR255W
gene id: 559292:YBR255W
uniprot id: P38335
names: Disruption Phenotype
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane
messages: Present with 396 molecules/cell in log phase SD medium.
messages: Shows a slower growth rate on YPD and minimal medium at 15 degrees Celsius. Synthetically sick with temperature-sensitive CDC13-1 mutant.

559292:YKL014C
gene id: 559292:YKL014C
uniprot id: P34241
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Associates with pre-60S ribosomal particles. Predominantly associated with the 27SA2 pre-rRNA. Can associate with a subset of box H/ACA and box C/D small nucleolar RNPs (snoRNPs) required for peptidyl transferase center modification and with small RNAs snR37 and snR42. Interacts with URB2. Together with DBP6, NOP8, URB2 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.
messages: Present with 5890 molecules/cell in log phase SD medium.
messages: Required for 60S ribosomal subunit formation and pre-rRNA processing. Required for normal accumulation of 25S and 5.8S rRNAs.
messages: nucleolus

559292:YDL100C
gene id: 559292:YDL100C
uniprot id: Q12154
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895). Interacts with the chloride channel protein GEF1.
messages: Present with 17300 molecules/cell in log phase SD medium.

559292:YOR008C
gene id: 559292:YOR008C
uniprot id: P54867
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Glycosylated. Phosphorylated. Phosphorylation serves a negative regulatory role.
messages: Lack of SLG1 leads to a significant defect of 1,3-beta-glucan synthesis and confers sensitivity to caffeine, SDS, Calcofluor and alkaline pH stress. Deletion of residues 21-256 results in non-functional protein, removal of residues 21-110 yields a protein still able to confer some tolerance to alkaline stress, and deletion of residues 116-256 has no effect on the function.
messages: Plays a role during G1 to regulate entering or exiting the cell cycle. Involved in stress responses. Has a role in cell wall integrity signaling. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1. Important regulator of the actin cytoskeleton rearrangements in conditions of cell wall expansion and membrane stretching. Specifically required for the actin reorganization induced by hypo-osmotic shock. Multicopy suppressor of 1,3-beta-glucan synthase (GS). Activates GS upstream of RHO1. Acts positively on the PKC1-MAPK pathway. Activates transiently SLT2 during alkaline stress, which leads to an increase in the expression of several specific genes.
messages: Present with 664 molecules/cell in log phase SD medium.

559292:YPR093C
gene id: 559292:YPR093C
uniprot id: Q06834
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Required for tolerance to alcohol.

559292:YNL245C
gene id: 559292:YNL245C
uniprot id: P53854
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Belongs to the CWC25 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus
messages: Present with 861 molecules/cell in log phase SD medium.

559292:YKR078W
gene id: 559292:YKR078W
uniprot id: P36158
names: Miscellaneous
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YLR064W
gene id: 559292:YLR064W
uniprot id: Q12144
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Endoplasmic reticulum membrane
messages: Present with 2240 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YBR279W
gene id: 559292:YBR279W
uniprot id: P38351
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAF1 family.
messages: Component of the PAF1 complex which consists of at least CDC73, CTR9, LEO1, PAF1 and RTF1. Interacts with FACT subunits POB3 and SPT16.
messages: Present with 1040 molecules/cell in log phase SD medium.
messages: The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of the RAD6/UBC2-BRE1 ubiquitin ligase complex, which ubiquitinates histone H2B to form H2BK123ub1. Also required for the methylation of histone H3 by the COMPASS complex to form H3K4me, by SET2 to form H3K36me, and by DOT1 to form H3K79me. RNA polymerase II associated protein important for transcription of a subset of genes. Required for both positive and negative regulation. Negatively regulates MAK16 expression. Also required for efficient CLN2 transcription in late G1 and may be involved in transcription of galactose-inducible genes.
messages: nucleoplasm

559292:YCL017C
gene id: 559292:YCL017C
uniprot id: P25374
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Catalyzes the removal of elemental sulfur from cysteine to produce alanine (PubMed:15220327). It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters (PubMed:10406803, PubMed:10551871, PubMed:15220327, PubMed:31040179). Plays a role in both tRNA-processing and mitochondrial metabolism (PubMed:15220327). Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs (PubMed:14722066, PubMed:15220327, PubMed:8444805).
messages: Impairs cysteine desulfurase activity of mitochondria. Leads to strong accumulation of free iron, not bound to heme or Fe/S clusters, in mitochondria, as well as to decreased amounts of the mitochondrial Fe/S proteins including aconitase and succinate dehydrogenase. Leads also to accumulation of 5-methoxycarbonylmethyluridine (mcm5U) and a concomitant decrease in 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs. Increases association between GRX5 and SSQ1 (PubMed:23615440).
messages: Mitochondrion
messages: Present with 504 molecules/cell in log phase SD medium.
messages: the N-terminal beta-strand formed by residues 99-104 is essential for the function.

559292:YGR008C
gene id: 559292:YGR008C
uniprot id: P16965
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STF2 family.
messages: Mitochondrion
messages: Present with 5330 molecules/cell in log phase SD medium.
messages: This is one of two stabilizing factors of the inactive mitochondrial F0F1-ATPase. It binds to the F0 part and facilitates the binding of both the inhibitor and the 9 kDa protein to F1.

559292:YML043C
gene id: 559292:YML043C
uniprot id: Q04712
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex.
messages: Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN11 interacts with RRN6, RRN7 and SPT15.
messages: Present with 476 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YNR014W
gene id: 559292:YNR014W
uniprot id: P53719
names: Miscellaneous
messages: Present with 2360 molecules/cell in log phase SD medium.

559292:YDL036C
gene id: 559292:YDL036C
uniprot id: Q12069
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase RluA family.
messages: Mitochondrion
messages: Present with 639 molecules/cell in log phase SD medium.
messages: Responsible for synthesis of pseudouridine from uracil-32 in mitochondrial transfer RNAs.

559292:YGL089C
gene id: 559292:YGL089C
uniprot id: P32435
names: Function
messages: The active factor is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type a cells and synchronizing them with type alpha.

559292:YPR058W
gene id: 559292:YPR058W
uniprot id: P32331
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Secondary mitochondrial glycine transporter required for the biosynthesis of heme at high glycine concentrations. Imports the precursor glycine into the mitochondrial matrix, where it is condensed with succinyl-CoA to produce 5-aminolevulinate (ALA), the first step of heme biosynthesis.

559292:YPR067W
gene id: 559292:YPR067W
uniprot id: Q12425
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
messages: Mitochondrion matrix
messages: Present with 1560 molecules/cell in log phase SD medium.

559292:YBR238C
gene id: 559292:YBR238C
uniprot id: P38330
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMD9 family.
messages: May be involved in the processing or stability of mitochondrial mRNAs.
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Phosphorylated. Phosphorylation promotes binding to RNA.
messages: Present with 2080 molecules/cell in log phase SD medium.

559292:YMR173W
gene id: 559292:YMR173W
uniprot id: P18899
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
messages: Belongs to the DDR48 family.
messages: DNA damage-responsive protein that may be required for maintaining the rate of spontaneous mutagenesis. Shows low ATP and GTP hydrolysis activity. Dispensable for acquisition of thermotolerance and does not play a significant role in recovery or protection of cells from acute heat shock.
messages: Expression is induced by DNA damage, as well as by salt, oxidative, and heat-shock stress.
messages: Probably highly glycosylated.
messages: Shows a slightly altered sensitivity to killing by 4-nitroquinoline-1-oxide and to heat shock; and a 6- to 14-fold reduction of the spontaneous mutation rate of reversion of a HIS4 mutation.
messages: sequence is a contaminating peptide from a S.cerevisiae glycogen synthase purification.

559292:YDR363W-A
gene id: 559292:YDR363W-A
uniprot id: O94742
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the DSS1/SEM1 family.
messages: Impairs mRNA export and transcription elongation, and induces strong transcription-associated hyperrecombination phenotypes.
messages: Part of the 26S proteasome. Associates with the nuclear pore complex (NPC)-associated TREX-2 complex and the COP9 signalosome. Interacts with CSN12 and THP3.
messages: Present with 5590 molecules/cell in log phase SD medium.
messages: Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Associates also with the TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation.

559292:YDR368W
gene id: 559292:YDR368W
uniprot id: Q12458
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldo/keto reductase family.
messages: Cytoplasm
messages: Present with 14100 molecules/cell in log phase SD medium.

559292:YJR050W
gene id: 559292:YJR050W
uniprot id: P21374
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ISY1 family.
messages: Belongs to the NTC complex (or PRP19-associated complex), composed of at least CEF1, CLF1, ISY1, NTC20, SNT309, SYF1, SYF2, and PRP19. The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex (or CEF1-associated complex) reminiscent of a late-stage spliceosome composed also of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, LEA1, MSL1, PRP8, PRP9, PRP11, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNU114, SPP2, RSE1 and YJU2. Interacts with CEF1, CWC2, CLF1, and SYF1.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing and cell cycle control. As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. The cell cycle arrest of SYF2 defective cells may be due to the inefficient splicing of TUB1. Also involved in DNA repair.
messages: Nucleus
messages: Present with 1990 molecules/cell in log phase SD medium.

559292:YGR085C
gene id: 559292:YGR085C
uniprot id: Q3E757
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). uL5 forms a heterotrimeric complex with uL18/RPL5 and SYO1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer (PubMed:23118189).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Nucleus
messages: Present with 21200 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL5 in yeast.

559292:YHR053C
gene id: 559292:YHR053C
uniprot id: P0CX80
uniprot id: P0CX81
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 12 family.
messages: Contains 1 metal-binding domain: 6 to 8 copper ions are chelated within a single copper-thiolate cluster and are coordinated via cysteinyl thiolate bridges to 10 cysteine ligands. 6 copper ions are trigonally coordinated, whereas the other 2 are only digonally coordinated.
messages: Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins.
messages: There are 2 copies for copper thionein in yeast. The 2 identical copies CUP1-1 and CUP1-2 are arranged in tandem.

559292:YGR165W
gene id: 559292:YGR165W
uniprot id: P53292
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS45 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Present with 3460 molecules/cell in log phase SD medium.

559292:YCR107W
gene id: 559292:YCR107W
uniprot id: P25612
names: Similarity
messages: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

559292:YBR255C-A
gene id: 559292:YBR255C-A
uniprot id: Q3E776
names: Subcellular Location Annotation
messages: Membrane

559292:YGR187C
gene id: 559292:YGR187C
uniprot id: P48362
names: Miscellaneous
names: Similarity
messages: Belongs to the HGH1 family.
messages: Present with 20800 molecules/cell in log phase SD medium.

559292:YAL022C
gene id: 559292:YAL022C
uniprot id: P31381
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.
messages: Membrane
messages: Present with 217 molecules/cell in log phase SD medium.

559292:YIL005W
gene id: 559292:YIL005W
uniprot id: P40557
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a membrane-bound chaperone in endoplasmic reticulum quality control. Probably facilitates presentation of substrate to membrane-bound components of the degradation machinery.
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum membrane
messages: Interacts with mutated PMA1-D378N but not wild type PMA1. Interacts with EUG1, KAR2, MPD1 and PDI1.
messages: Present with 6020 molecules/cell in log phase SD medium.

559292:YIL166C
gene id: 559292:YIL166C
uniprot id: P40445
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Allantoate permease family.
messages: Membrane

559292:YGR094W
gene id: 559292:YGR094W
uniprot id: P07806
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Mitochondrion
messages: Present with 358 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-47 of isoform Mitochondrial.

559292:YKL024C
gene id: 559292:YKL024C
uniprot id: P15700
names: Caution
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Present with 1500 molecules/cell in log phase SD medium.
messages: There is controversy about the substrate specificity of the enzyme. Next to the primary substrate UMP, PubMed:1333436 and Ref.8 report that the enzyme accepts also CMP and AMP as nucleoside monophosphates, but not GMP, whereas PubMed:2172245 and PubMed:8391780 report activity with GMP and dTMP, but not AMP or CMP.

559292:YNL072W
gene id: 559292:YNL072W
uniprot id: P53942
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Cytoplasm
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
messages: Nucleus
messages: Present with 623 molecules/cell in log phase SD medium.
messages: The RNase 2 complex is a heterotrimer composed of the catalytic subunit RNH201 and of the non-catalytic subunits RNH202 and RNH203.

559292:YMR084W
gene id: 559292:YMR084W
uniprot id: A2P2R3
names: Caution
names: Function
messages: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).
messages: This is a truncated version of a putative glutamine--fructose-6-phosphate aminotransferase. Strain S288c has a frameshift in position 258, which disrupts the gene coding for this protein and produces two ORFs YMR084W and YMR085W. A contiguous sequence for this protein can be found in strain YJM789 (AC A6ZME2).

559292:YJL160C
gene id: 559292:YJL160C
uniprot id: P46999
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIR protein family.
messages: Cell cycle-regulated. Expression peaks during mitosis.
messages: Component of the outer cell wall layer (By similarity). May be involved in meiosis and sporulation.
messages: Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from specific glutamines within the PIR1/2/3 repeats, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
messages: The PIR1/2/3 repeats are required for the covalent linkage to the cell wall (By similarity). Their number varies among different strains of S.cerevisiae.
messages: cell wall

559292:YLR284C
gene id: 559292:YLR284C
uniprot id: Q05871
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: By oleate.
messages: Essential for the beta oxidation of unsaturated fatty acids.
messages: Homohexamer, dimer of trimers. Interacts with DCI1.
messages: Peroxisome

559292:YLR314C
gene id: 559292:YLR314C
uniprot id: P32457
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SHS1 and rearranges to a cortical collar of highly ordered filaments at the mother-bud-neck. A complex formed by CDC3, CDC10, CDC11 and CDC12 is capable of forming long filaments in vitro and the components seem to be present in a 2:2:2:2 arrangement in vivo. The filaments are proposed to be formed by the end-to-end polymerization of CDC3-CDC12-CDC11 complexes with CDC10 serving as a bridge to bundle the polymers into paired filaments. Component of the GIN4 complex composed of at least BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. Self-associates. Interacts with SIZ1 and SYP1.
messages: Membrane
messages: Phosphorylated by CDC28. Phosphorylation at the end of G1 may facilitate initiation of a new cell cycle by promoting disassembly of the obsolete septin ring from the previous cell cycle.
messages: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
messages: Sumoylated during mitosis on the mother cell side of the bud neck by UBC9/SIZ1. Sumoylation probably plays a central role in regulating septin ring disassembly during the cell cycle.

559292:YJR045C
gene id: 559292:YJR045C
uniprot id: P0CS90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of the PAM complex, at least composed of SSC1 (mtHsp70), MGE1, TIM44, PAM16/TIM16, PAM17 and PAM18/TIM14. In the complex, SSC1 interacts directly with PAM18 and TIM44. Interacts with NAP1.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein. Required for the import of the processed frataxin homolog YFH1 into the mitochondrion.
messages: Mitochondrion matrix
messages: S.cerevisiae displays strain polymorphism with regard to Endo.SceI endouclease activity. This is due to the mitochondrion-encoded, catalytic subunit ENS2, which exhibits strain polymorphism. It can be either present as continuous ORF in the mitochondrial genome (e.g. strain IAM 4274), present but disrupted by the insertion of GC clusters (e.g. strain D273-10B/A), or completely absent in the mitochondrial genome (e.g. strain S288c). Sequences for the 2 subunits ENS2 (AC P12294) and SSC1 (AC P0CS91) for an active Endo.SceI endonuclease can be found in strain IAM 4274.

559292:YMR157C
gene id: 559292:YMR157C
uniprot id: Q03798
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM36 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion membrane
messages: Present with 1710 molecules/cell in log phase SD medium.

559292:YDL240W
gene id: 559292:YDL240W
uniprot id: P35688
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts in signal transduction. Activates CDC42, RHO1 and RHO2. Negatively regulates 1,3-beta-glucan synthesis. May be responsible for the down-regulation of CDC42 during mating.
messages: Bud
messages: Bud neck
messages: Cytoplasm
messages: Highly expressed during sporulation.
messages: Interacts with CDC42, RHO1 and RHO2.
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YPR202W
gene id: 559292:YPR202W
uniprot id: Q08993
names: Caution
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Could be the product of a pseudogene. Although strongly related to DNA helicases, it lacks the helicase domains, suggesting that it has no helicase activity.
messages: Down-regulated at low calcium levels.

559292:YOR043W
gene id: 559292:YOR043W
uniprot id: P12611
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the WHI2 family.
messages: Interacts with MSN2 and PSR1.
messages: Negative mutants fail to enter the G0 phase under conditions of carbon limitation.
messages: Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.
messages: Present with 1800 molecules/cell in log phase SD medium.

559292:YDL156W
gene id: 559292:YDL156W
uniprot id: Q12510
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Closely coexpressed with replication factor A (RF-A), the cohesion complex and the DNA polymerases alpha, delta and epsilon.
messages: Cytoplasm
messages: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA in vitro (PubMed:22367945). May be involved in DNA-metabolic processes (PubMed:23349438).
messages: Nucleus
messages: Present with 3810 molecules/cell in log phase SD medium.

559292:YKR093W
gene id: 559292:YKR093W
uniprot id: P32901
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane
messages: Uptake of small peptides.

559292:YBL092W
gene id: 559292:YBL092W
uniprot id: P38061
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

559292:YPL112C
gene id: 559292:YPL112C
uniprot id: Q02969
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homooligomer. Interacts with PEX27 and PEX34.
messages: Peroxisome membrane
messages: Present with 2420 molecules/cell in log phase SD medium.
messages: Required for regulation of peroxisome size and maintenance. Has a role in the import of peroxisomal matrix proteins. Imports RHO1 into the peroxisome. Also promotes peroxisome division and biogenesis.

559292:YKL015W
gene id: 559292:YKL015W
uniprot id: P25502
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Positive activator of the proline utilization pathway. Binds to the promoters of PUT1 and PUT2 genes. Recognizes and binds to the DNA sequence 5'-CGG-N(10)-CCG-3'.
messages: Present with 736 molecules/cell in log phase SD medium.

559292:YKL060C
gene id: 559292:YKL060C
uniprot id: P14540
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: Homodimer.
messages: Present with 1020000 molecules/cell in log phase SD medium.

559292:YLR438W
gene id: 559292:YLR438W
uniprot id: P07991
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: By arginine and urea.
messages: Catalyzes the transamination of ornithine into L-glutamate gamma-semialdehyde, the second step of arginine degradation.
messages: Cytoplasm
messages: Present with 72000 molecules/cell in log phase SD medium.

559292:YPR201W
gene id: 559292:YPR201W
uniprot id: Q06598
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Expression is highly induced by arsenite and antimonite.
messages: Heterologous expression endows plants with greater arsenic resistance by enhancing arsenite efflux. Reduces arsenic accumulation in rice grains (PubMed:22107880). Does not lower significantly arsenic tissue levels in Arabidopsis (PubMed:22380876).
messages: Leads to sensitivity to antimony, tellurite, cadmium, and phenylarsine oxide.
messages: Plasma membrane transporter that confers resistance to toxic metalloids by mediating extrusion of arsenite (As(III)) and antimonite (Sb(III)) out of cells. Displays low-affinity As(III)/H(+) and Sb(III)/H(+) exchange activity.

559292:YOL157C
gene id: 559292:YOL157C
uniprot id: Q08295
names: Function
names: Induction
names: Similarity
messages: Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose.
messages: Belongs to the glycosyl hydrolase 13 family.
messages: By ethanol.

559292:YBR147W
gene id: 559292:YBR147W
uniprot id: P38279
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the laat-1 family.
messages: May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole. Required for optimal growth in synthetic medium.
messages: Mitochondrion membrane
messages: Resistant to fluconazole. Increased resistance to caspofungin. Suppresses CDC13-1 temperature sensitivity.
messages: Up-regulated by addition of ammonia or amino acids to a nitrogen-depleted medium. Down-regulated by excess lysine.
messages: Vacuole membrane

559292:YOR086C
gene id: 559292:YOR086C
uniprot id: Q12466
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tricalbin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with TCB2 via its C-terminal domain.
messages: May play a role in membrane trafficking.
messages: Present with 6140 molecules/cell in log phase SD medium.
messages: The C-terminal C2 domain shows Ca(2+)-dependent phospholipid binding. It binds to phosphatidylserine, phosphatidylinositol and various phosphoinositides. The other C2 domains do not retain all 5 conserved Asp residues found in calcium-binding C2 domains.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

559292:YPR095C
gene id: 559292:YPR095C
uniprot id: Q06836
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Catalyzes both the GDP release by and the GTP binding to ARF2. Has no exchange activity on Rab GTPases. Involved in vesicular transport.
messages: Inhibited by brefeldin A.
messages: Present with 279 molecules/cell in log phase SD medium.
messages: The SEC7 domain is sufficient for nucleotide exchange activity.

559292:YOR317W
gene id: 559292:YOR317W
uniprot id: P30624
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. Also facilitates the transport of LCFAs into the cell, either by active transport or by decreasing the intracellular LCFA concentration (PubMed:8206942, PubMed:11477098, PubMed:12601005, PubMed:27136724). It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities (PubMed:8206942). Also involved in long-chain base (LCB) uptake of sphingolipids. In contrast ot LCFA uptake, LCB uptake does not require ATP, suggesting that the enzyme is directly involved in active LCB uptake (PubMed:27136724). Involved in the sphingolipid-to-glycerolipid metabolic pathway, converting the shingolipid metabolite hexadecenoic acid to hexadecenoyl-CoA, which is then further converted to glycerolipids (PubMed:22633490).
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Cell membrane
messages: Interacts with FAT1.
messages: Lipid droplet
messages: Present with 7470 molecules/cell in log phase SD medium.
messages: The FACS motif is required for catalytic activity and substrate specificity.

559292:YGL108C
gene id: 559292:YGL108C
uniprot id: P53139
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Myristoylated.
messages: Present with 2430 molecules/cell in log phase SD medium.
messages: The N-myristoylated protein is further palmitoylated by ERF2, PFA4 and slightly by PFA5, but not by PFA3.
messages: To S.pombe new13.

559292:YAL025C
gene id: 559292:YAL025C
uniprot id: P10962
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK16 family.
messages: Its role might be as part of the apparatus concerned with the nuclear events of the cell cycle.
messages: Nucleus

559292:YER169W
gene id: 559292:YER169W
uniprot id: P39956
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 2229 molecules/cell in log phase SD medium.
messages: RAD53-dependent phosphorylated in response to DNA damage.
messages: Transcriptional repressor of photolyase PHR1. Recognizes and binds the sequence AG(4) in the upstream repressing sequence of PHR1. Derepresses PHR1 transcription when phosphorylated.

559292:YOR099W
gene id: 559292:YOR099W
uniprot id: P27810
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Golgi apparatus membrane
messages: Mannosyltransferase that transfers a mannose residue from GDP-mannose to a range of acceptors in vitro, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
messages: N-glycosylated.
messages: Present with 5480 molecules/cell in log phase SD medium.

559292:YGL087C
gene id: 559292:YGL087C
uniprot id: P53152
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The UBC13/MMS2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.
messages: Heterodimer with UBC13.
messages: Present with 2760 molecules/cell in log phase SD medium.

559292:YMR067C
gene id: 559292:YMR067C
uniprot id: P54730
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
messages: Nucleus
messages: Present with 3570 molecules/cell in log phase SD medium.

559292:YEL053C
gene id: 559292:YEL053C
uniprot id: Q02197
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of MAK3, MAK10 and MAK31.
messages: Component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein. MAK10 has a role in the propagation of L-A and M viruses, perhaps in the viral assembly. It is apparently directly needed for optimum respiration.
messages: Cytoplasm
messages: Glucose-repressed.
messages: Present with 1970 molecules/cell in log phase SD medium.

559292:YER001W
gene id: 559292:YER001W
uniprot id: P39106
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Present with 1780 molecules/cell in log phase SD medium.
messages: Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications.

559292:YLL028W
gene id: 559292:YLL028W
uniprot id: Q07824
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
messages: By transcription factor PDR1, by transcription factor HAA1 in response to acetaldehyde accumulation and by the non-steroidal anti-inflammatory drug indomethacin.
messages: Cell membrane
messages: Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Catalyzes polyamine uptake at alkaline pH and excretion at acidic pH. Recognizes spermidine, spermine and putrescine, the polyamine analogs methylglyoxal bis(guanylhydrazone) (MGBG) and paraquat, the antimalarial drug quinidine, and cycloheximide. Confers resistance to the non-steroidal anti-inflammatory drug indomethacin.
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YLR085C
gene id: 559292:YLR085C
uniprot id: Q12509
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP6 subfamily.
messages: Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.
messages: Cytoplasm
messages: Nucleus
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YOL137W
gene id: 559292:YOL137W
uniprot id: Q08280
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Present with 414 molecules/cell in log phase SD medium.
messages: Probable transporter.
messages: cis-Golgi network membrane

559292:YBL005W
gene id: 559292:YBL005W
uniprot id: P33200
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5.
messages: Present with 166 molecules/cell in log phase SD medium.

559292:YKL191W
gene id: 559292:YKL191W
uniprot id: P32461
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abolishes diphthamide modification of elongation factor 2 (PubMed:32576952). Abolishes the interaction between DPH1 and DPH3 (PubMed:18627462). Resistance to diphtheria toxin, sordarin, and zymocin (PubMed:18627462, PubMed:27694803, PubMed:32576952). Sensitive to hygromycin B (PubMed:32576952).
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:31463593, PubMed:24422557, PubMed:18627462). Interacts with DPH1; the interaction is direct (PubMed:15485916, PubMed:23645155, PubMed:31463593). Interacts with KTI11/DPH3 (PubMed:12940988, PubMed:27694803, PubMed:18627462).
messages: Cytoplasm
messages: Present with 3486 molecules/cell in log phase SD medium.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:8406038, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:32576952, PubMed:34154323). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:8406038, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (PubMed:31463593).

559292:YIL013C
gene id: 559292:YIL013C
uniprot id: P40550
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane
messages: Transporter involved in the uptake of sterol.

559292:YJL190C
gene id: 559292:YJL190C
uniprot id: P0C0W1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 40400 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS8 in yeast.

559292:YFR004W
gene id: 559292:YFR004W
uniprot id: P43588
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase M67A family.
messages: Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Interacts directly with RPN8 and STS1.
messages: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. RPN11 is the only catalytically active member of the lid and serves as the essential deubiquitinase of the proteasome.
messages: N-acetylated by NAT3.
messages: Present with 16400 molecules/cell in log phase SD medium.
messages: The JAMM motif is required for the deubiquitination and degradation of ubiquitinated substrates.

559292:YKL171W
gene id: 559292:YKL171W
uniprot id: P36003
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Interacts with URE2 and GDH2. Interacts also with the TORC1 kinase complex.
messages: Serine/threonine-protein kinase involved in the phosphorylation of the NAD(+)-dependent glutamate dehydrogenase GDH2. When overexpressed, confers hypersensitivity to rapamycin and induces rapid nuclear accumulation of GLN3 to activate the transcription of nitrogen-regulated genes.

559292:YPR108W
gene id: 559292:YPR108W
uniprot id: Q06103
names: Function
names: Miscellaneous
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Present with 51900 molecules/cell in log phase SD medium.

559292:YPL059W
gene id: 559292:YPL059W
uniprot id: Q02784
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutaredoxin family. Monothiol subfamily.
messages: Homodimer (By similarity). Interacts with SSQ1 (PubMed:23615440). Interacts with BOL1 (PubMed:27532773).
messages: Mitochondrion matrix
messages: Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:11950925, PubMed:12730244, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISU1 and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:27532773, PubMed:23615440).
messages: Present with 6260 molecules/cell in log phase SD medium.

559292:YEL032W
gene id: 559292:YEL032W
uniprot id: P24279
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Necessary for cell growth.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer. Interacts with CSM1.
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus
messages: Present with 35100 molecules/cell in log phase SD medium.

559292:YOR195W
gene id: 559292:YOR195W
uniprot id: Q08581
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cleaved by ESP1 at the onset of anaphase.
messages: Has a role in spindle assembly and stability. Required to ensure a timely exit form mitosis. Essential to maintain pre-anaphase spindle polarity. Associates to the plus ends of the microtubules at the kinetochore and spindle midzone. A component of the FEAR (CDC14 Early Anaphase Release) network which promotes CDC14 release from the nucleolus during early anaphase. Required for proper chromosome segregation during meiosis I where it prevents premature sister chromatid separation.
messages: Phosphorylated by CDC5/Polo-like kinase at the onset of anaphase. Phosphorylation takes places at proximity to cleavage sites and is required for an efficient cleavage by ESP1. Phosphorylated also by CDC28.
messages: Present with 314 molecules/cell in log phase SD medium.
messages: centromere
messages: kinetochore
messages: spindle pole body

559292:YIR018W
gene id: 559292:YIR018W
uniprot id: P40574
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. YAP subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it is a coregulator for the expression of ribosomal genes, while its own expression is induced by the cell cycle specific activator SBF (SWI4-SWI6).

559292:YBL111C
gene id: 559292:YBL111C
uniprot id: Q3E7Y5
names: Caution
names: Miscellaneous
names: Similarity
messages: Although strongly related to DNA helicases, it lacks the helicase C-terminal domain, suggesting that it has no helicase activity.
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Present with 279 molecules/cell in log phase SD medium.

559292:YNL064C
gene id: 559292:YNL064C
uniprot id: P25491
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Interacts with HAP1. Component of the HMC including HAP1, SRO9 and YDJ1.
messages: Present with 119000 molecules/cell in log phase SD medium.
messages: Probably involved in mitochondrial protein import. Is also required for efficient translocation of pre-pro-alpha-factor. Involved in heme regulation of HAP1, as a component of the high-molecular-weight (HMC) complex.
messages: YDJ1 is a heat shock gene whose expression increases moderately at elevated temperatures.
messages: perinuclear region

559292:YPR074C
gene id: 559292:YPR074C
uniprot id: P23254
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.
messages: Present with 40300 molecules/cell in log phase SD medium.

559292:YPR204W
gene id: 559292:YPR204W
uniprot id: Q08995
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
messages: Induced in absence of telomerase TLC1.

559292:YER136W
gene id: 559292:YER136W
uniprot id: P39958
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Interacts with the GDP-bound form of Rab GTPase YPT1. Interacts with YPT10.
messages: Present with 7280 molecules/cell in log phase SD medium.
messages: Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway (PubMed:8157010). Extracts GDP-bound YPT7 from vacuolar membranes, antagonizing vacuolar membrane fusion (PubMed:11118206).

559292:YDL064W
gene id: 559292:YDL064W
uniprot id: P50623
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: E2 ubiquitin-like--protein ligase mediating SUMO/Smt3 attachment to septins and PCNA. Seems to be involved in degradation of S- (CLB5) and M-phase cyclins (CLB2).
messages: Interacts with SIZ1.
messages: Nucleus
messages: Present with 2600 molecules/cell in log phase SD medium.

559292:YCR048W
gene id: 559292:YCR048W
uniprot id: P25628
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

559292:YDR156W
gene id: 559292:YDR156W
uniprot id: P50106
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. RPA14 seems to play a role in the stability of subunits RPO26 and RPA43. In vitro, the RPA14-RPA43 subcomplex binds single-stranded RNA.
messages: Present with 3100 molecules/cell in log phase SD medium.
messages: The N-terminus is blocked.
messages: nucleolus

559292:YOR190W
gene id: 559292:YOR190W
uniprot id: P32603
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
messages: Late stages of sporulation, during ascospore wall formation. Probably functions before partitioning of nuclei or is distributed to developing ascospores prior to the completion of pro-spore walls.
messages: Probably involved in the processes of spore formation and contributes to ascospore thermoresistance by participating in the morphogenesis of ascospore walls. The enzyme may do this by modifying glucan linkages in the developing ascospore wall, thus strengthening it or lending it plasticity.
messages: Secreted

559292:YMR291W
gene id: 559292:YMR291W
uniprot id: Q03533
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Interacts with RIM11.
messages: Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.
messages: Nucleus
messages: Present with 10200 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase shown to have protein phosphorylation activity in vitro.

559292:YML050W
gene id: 559292:YML050W
uniprot id: Q04689
names: Disruption Phenotype
names: Similarity
messages: Belongs to the AIM32 family.
messages: Increases frequency of mitochondrial genome loss.

559292:YOL003C
gene id: 559292:YOL003C
uniprot id: Q12006
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Leads to the retention of non-palmitoylated CHS3 in the endoplasmic reticulum and reduced levels of chitin on the cell wall.
messages: Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. Palmitoylates several amino acid permeases (PubMed:16751107). Palmitoylates chitin synthase CHS3, which is required for its proper export from the ER (PubMed:16818716, PubMed:28346351). Can palmitoylate RAS2 in vitro (PubMed:12379641).
messages: The DHHC domain is required for palmitoyltransferase activity.

559292:YCR104W
gene id: 559292:YCR104W
uniprot id: P25610
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Membrane

559292:YNL284C-A
gene id: 559292:YNL284C-A
uniprot id: Q12391
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-NL1 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YKL105C
gene id: 559292:YKL105C
uniprot id: P34250
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEG1 family.
messages: Cell membrane
messages: Component of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains termed MCCs on the plasma membrane.
messages: Likely plays only a minor role in eisosome assembly.
messages: Present with 538 molecules/cell in log phase SD medium.

559292:YPR127W
gene id: 559292:YPR127W
uniprot id: Q06494
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
messages: Cytoplasm
messages: Nucleus
messages: Present with 2190 molecules/cell in log phase SD medium.

559292:YNR017W
gene id: 559292:YNR017W
uniprot id: P32897
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. The complex interacts with the TIM44 component of the PAM complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane
messages: Present with 1440 molecules/cell in log phase SD medium.

559292:YOR393W
gene id: 559292:YOR393W
uniprot id: P0CX10
uniprot id: P0CX11
names: Similarity
messages: Belongs to the enolase family.

559292:YEL017C-A
gene id: 559292:YEL017C-A
uniprot id: P40975
names: Caution
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: Monomer and homodimer. Associated with the 100 kDa subunit of the plasma membrane H(+)-ATPase.
messages: Present with 74700 molecules/cell in log phase SD medium.

559292:YHR024C
gene id: 559292:YHR024C
uniprot id: P11914
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of MAS2 (alpha) and MAS1 (beta) subunits, forming the mitochondrial processing protease (MPP) in which MAS2 is involved in substrate recognition and binding and MAS1 is the catalytic subunit.
messages: Mitochondrion matrix
messages: Present with 31400 molecules/cell in log phase SD medium.
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
messages: Was originally thought to be the catalytic subunit (PubMed:3061797). The low processing activity which was previously observed with alpha-MPP which has been purified from a mitochondrial extract is most likely due to contamination by the beta-subunit. Does not seem to have protease activity as it lacks the zinc-binding site (PubMed:9299349).

559292:YLR073C
gene id: 559292:YLR073C
uniprot id: Q08003
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RFU1 family.
messages: Endosome
messages: Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.
messages: Interacts with BRO1 and DOA4.
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YOR142W
gene id: 559292:YOR142W
uniprot id: P53598
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Induced during growth on nonfermentable carbon sources and repressed during growth on glucose.
messages: Mitochondrion
messages: Present with 18400 molecules/cell in log phase SD medium.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:9874242). The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit (By similarity).

559292:YDR142C
gene id: 559292:YDR142C
uniprot id: P39108
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat peroxin-7 family.
messages: Interacts with PEX21.
messages: Peroxisome matrix
messages: Present with 589 molecules/cell in log phase SD medium.
messages: Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal, such as 3-oxoacyl-CoA thiolase (PubMed:7957058, PubMed:7535304, PubMed:23812376). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (PubMed:23812376). Cargo protein-binding triggers interaction with PEX21 and formation of a ternary complex composed of PEX21 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (PubMed:9094717, PubMed:23812376).
messages: cytosol

559292:YBR123C
gene id: 559292:YBR123C
uniprot id: P32367
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIIC subunit 5 family.
messages: Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with TFC3, TFC4 and TFC6.
messages: Nucleus
messages: Present with 15800 molecules/cell in log phase SD medium.
messages: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with TFC3 and TFC6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability.

559292:YNL046W
gene id: 559292:YNL046W
uniprot id: P53956
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YGR161W-A
gene id: 559292:YGR161W-A
uniprot id: P0CX61
uniprot id: P0CX62
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.

559292:YOL088C
gene id: 559292:YOL088C
uniprot id: Q99316
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum
messages: Non essential disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. Able to fold proteins by being directly oxidized by ERO1.
messages: Present with 1520 molecules/cell in log phase SD medium.

559292:YPL244C
gene id: 559292:YPL244C
uniprot id: Q12520
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane
messages: May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum. Overexpression confers resistance to the immunosuppressive drug, leflunomide.

559292:YOL092W
gene id: 559292:YOL092W
uniprot id: Q12010
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the laat-1 family.
messages: May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole.
messages: Present with 1800 molecules/cell in log phase SD medium.
messages: Resistant to canavanine.
messages: Vacuole membrane

559292:YHL021C
gene id: 559292:YHL021C
uniprot id: P23180
names: Cofactor
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Accumulates as a carbonylated protein in absence of PIM1, suggesting that the PIM1 protease is responsible for the degradation of its oxidized form in mitochondria.
messages: Belongs to the gamma-BBH/TMLD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion
messages: Present with 5800 molecules/cell in log phase SD medium.

559292:YNL313C
gene id: 559292:YNL313C
uniprot id: P42842
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC27 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 8070 molecules/cell in log phase SD medium.
messages: Required for the maintenance of the cell wall integrity.
messages: Target of SBF and MBF transcription factor complexes that activate gene expression during the G1/S transition of the cell cycle.

559292:YMR201C
gene id: 559292:YMR201C
uniprot id: P28519
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPA family.
messages: Component of the nucleotide excision repair factor 1 (NEF1) complex consisting of RAD1, RAD10 and RAD14.
messages: Involved in nucleotide excision repair. Binds specifically to damaged DNA. Required for the incision step.
messages: Nucleus
messages: Present with 1030 molecules/cell in log phase SD medium.

559292:YPL143W
gene id: 559292:YPL143W
uniprot id: P05744
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL33 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: There are 2 genes for eL33 in yeast.

559292:YDR002W
gene id: 559292:YDR002W
uniprot id: P41920
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RANBP1 family.
messages: Cytoplasm
messages: Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.
messages: Interacts with GSP1 and PRP20.
messages: Nucleus

559292:YJL132W
gene id: 559292:YJL132W
uniprot id: P47014
names: Subcellular Location Annotation
messages: Membrane

559292:YKL119C
gene id: 559292:YKL119C
uniprot id: P32341
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Present with 2030 molecules/cell in log phase SD medium.
messages: Required for vacuolar ATPase assembly.

559292:YBL010C
gene id: 559292:YBL010C
uniprot id: P32788
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus
messages: Present with 1320 molecules/cell in log phase SD medium.

559292:YLR006C
gene id: 559292:YLR006C
uniprot id: Q07084
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, maintained in a phosphorylated and inactive state by the phosphorelay intermediate protein YPD1. Under conditions of high osmolarity, the histidine kinase SLN1 is no longer active and the unphosphorylated form of SSK1 interacts with and activates SSK2 and SSK22, two MAPKKKs that further stimulate the PBS2-HOG1 MAPKK-MAPK cascade. Unphosphorylated SSK1 is subsequently degraded by the UBC7-dependent ubiquitin-proteasome system to down-regulate the HOG1 pathway after completion of the osmotic adaptation.
messages: Interacts with SSK2, SSK22 and YPD1.
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: The phosphorelay mechanism involves the sequential transfer of a phosphate group from 'His-576' (H1) to 'Asp-1144' (D1) of SLN1, then to 'His-64' (H2) of YPD1 and finally to Asp-554 (D2) of SSK1.

559292:YPR184W
gene id: 559292:YPR184W
uniprot id: Q06625
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is inhibited by IGD1.
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Interacts with IGD1.
messages: Mitochondrion
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
messages: Present with 125 molecules/cell in log phase SD medium.

559292:YMR193W
gene id: 559292:YMR193W
uniprot id: P36525
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL28 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 4000 molecules/cell in log phase SD medium.

559292:YDL093W
gene id: 559292:YDL093W
uniprot id: P52867
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: PMT3 and PMT5 form a functional heterodimer. Forms also a minor complex with PMT2.
messages: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT3 and more rarely with PMT2 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins.

559292:YKL206C
gene id: 559292:YKL206C
uniprot id: P36040
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Component of the 20S proteasome chaperone. Forms a heterodimer with PBA1 that binds to proteasome precursors.
messages: Cytoplasm
messages: Deletion induces the unfolded protein response (UPR).
messages: Involved in 20S proteasome assembly. Required for maximal proteasome activity. Affects the chymotrypsin-like activity of the proteasome. Can be degraded by the proteasome. Involved in the endoplasmic reticulum-associated degradation (ERAD).
messages: Present with 2940 molecules/cell in log phase SD medium.

559292:YCL012C
gene id: 559292:YCL012C
uniprot id: Q8J0M4
names: Similarity
messages: Belongs to the UPF0357 family.

559292:YDL083C
gene id: 559292:YDL083C
uniprot id: P0CX51
uniprot id: P0CX52
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 33800 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS9 in yeast.

559292:YFL038C
gene id: 559292:YFL038C
uniprot id: P01123
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Forms a complex with the Rab escort protein (REP) MRS6, which is recognized by Rab geranylgeranyltransferase BET2-BET4. Interacts with the Rab GDP dissociation inhibitor GDI1, which can retrieve from and deliver to membranes the GDP-bound and prenylated form of YPT1. Interacts with YIP1, which is required for proper membrane targeting of prenylated YPT1. Interacts with YIF1, YIP3, YIP4 and YIP5.
messages: Golgi apparatus membrane
messages: In PubMed:3042385 the location of any palmitoylation was not determined. Mutagenesis of either Cys-205 or Cys-206 would disrupt normal geranylgeranylation, and there would be no primary membrane association for secondary S-palmitoylation to occur at some other position, for example Cys-23. Mutagenesis of both Cys-205 and Cys-206 is lethal, so protein production could not have been observed.
messages: Preautophagosomal structure membrane
messages: Prenylation is required for interaction with GDI1 and YIP1.
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). YPT1 is activated by the GEFs DSS4 and TRAPP complex, and inactivated by GAPs GYP1, GYP5 and GYP8.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. YPT1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Vesicular transport depends on shuttling of YPT1 between membrane and cytosol by GDI1, probably by recycling it to its membrane of origin after a vesicle fusion event. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins.

559292:YER159C
gene id: 559292:YER159C
uniprot id: P40096
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NC2 alpha/DRAP1 family.
messages: Component of the NC2 (negative cofactor 2) complex composed of BUR6 and NCB2. The NC2 complex associates with SPT15/TBP. Interacts with SPT15/TBP.
messages: Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP.
messages: Nucleus
messages: Present with 5130 molecules/cell in log phase SD medium.

559292:YDR206W
gene id: 559292:YDR206W
uniprot id: Q03466
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EST1 family.
messages: Interacts with NMD helicase UPF1 (PubMed:17984081). Interacts with CDC33 (PubMed:16467471).
messages: Nucleus
messages: P-body
messages: Plays a role in nonsense-mediated mRNA decay (NMD) (PubMed:16467471, PubMed:17984081). Recruits UPF1 to cytoplasmic mRNA decay bodies (P-bodies) (PubMed:17984081). Negative regulator of gene expression. Inhibits translation most likely through effects on eIF-4E (CDC33) (PubMed:16467471). Involved in telomere maintenance (PubMed:10688642).
messages: Results in stabilization of NMD targets.
messages: telomere

559292:YLR231C
gene id: 559292:YLR231C
uniprot id: Q05979
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 3060 molecules/cell in log phase SD medium.

559292:YBR176W
gene id: 559292:YBR176W
uniprot id: P38122
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PanB family.
messages: Impairs growth on beta-alanine but can still utilize pantothenic acid.
messages: Present with 1420 molecules/cell in log phase SD medium.
messages: Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase required for pantothenic acid biosynthesis (PubMed:11154694). Acts downstream in the pantothenic acid pathway (PubMed:11154694).

559292:YKL135C
gene id: 559292:YKL135C
uniprot id: P36000
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin.
messages: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). Interacts with CHC1. Interacts with APM2, probably forming an alternative AP-1-like complex.
messages: Belongs to the adaptor complexes large subunit family.
messages: Cell membrane
messages: Present with 2690 molecules/cell in log phase SD medium.
messages: coated pit

559292:YNL190W
gene id: 559292:YNL190W
uniprot id: P53872
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA14 family.
messages: Has statistically significant lower desiccation tolerance capacity.
messages: Hydrophilin which is essential to overcome the simple stress of the desiccation-rehydration process.
messages: Membrane
messages: Present with 1380 molecules/cell in log phase SD medium.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: Up-regulated in response to osmotic stress.
messages: cell wall

559292:YDL220C
gene id: 559292:YDL220C
uniprot id: P32797
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POL1, EST1, FUN12, STM1, STN1 and TEN1.
messages: Present with 319 molecules/cell in log phase SD medium.
messages: Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.
messages: telomere

559292:YAL013W
gene id: 559292:YAL013W
uniprot id: P31385
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
messages: Cytoplasm
messages: Nucleus

559292:Q0070
gene id: 559292:Q0070
uniprot id: Q9ZZX1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a 32 kDa catalytic subunit and a larger 60 kDa polypeptide subunit.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: In the N-terminal section; belongs to the heme-copper respiratory oxidase family.
messages: Membrane
messages: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-ATCTTCTCTTGATTAGCCCTGATCTACGG-3' after the nucleotide sequence ATTA leaving a four-base overhang and a 3'-OH.
messages: Mitochondrion
messages: The mature protein may arise from proteolytic cleavage of an in-frame translation of some COX1 exons plus the intron containing the aI5_alpha open reading frame.

559292:YIL173W
gene id: 559292:YIL173W
uniprot id: P40438
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family.
messages: Endosome membrane
messages: Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.
messages: Present with 319 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YPL167C
gene id: 559292:YPL167C
uniprot id: P14284
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Forms DNA polymerase zeta with REV7.
messages: Mitochondrion
messages: Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Translesion synthesis in S.cerevisiae may use a specialized DNA polymerase that is not required for other DNA replicative processes. Has a role in the bypass of abasic (AP) sites. Highly inefficient in incorporating nucleotides opposite the AP site, but efficiently extends from nucleotides, particularly an A, inserted opposite the lesion.
messages: Nucleus
messages: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.

559292:YML066C
gene id: 559292:YML066C
uniprot id: Q04658
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMA2 family.
messages: Endoplasmic reticulum
messages: Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane.
messages: Prospore membrane

559292:YOR131C
gene id: 559292:YOR131C
uniprot id: Q12486
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Cytoplasm
messages: Nucleus
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YKR028W
gene id: 559292:YKR028W
uniprot id: P36123
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the SIT4 protein phosphatase catalytic subunit in a cell-cycle-dependent manner.
messages: Belongs to the SAPS family.
messages: Cytoplasm
messages: Hyperphosphorylated in the absence of SIT4.
messages: Positive regulator of protein phosphatase SIT4. Involved in the general amino acid control (GAAC) response regulated by TOR. Involved in the dephosphorylation of the elongator complex subunit IKI3.

559292:YDR146C
gene id: 559292:YDR146C
uniprot id: P08153
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cell cycle-dependent phosphorylation of three serine residues prevents SWI5 from entering the nucleus, and it accumulates in the cytoplasm. As a consequence of CDC28 kinase inactivation at the end of anaphase, the three serine residues are dephosphorylated and SWI5 enters the nucleus to activate transcription. It is then rapidly degraded. Threonine phosphorylation also seems to occur.
messages: Cytoplasm
messages: Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis.
messages: Nucleus
messages: Phosphorylated by PHO85.
messages: Present with 688 molecules/cell in log phase SD medium.

559292:YBR186W
gene id: 559292:YBR186W
uniprot id: P38126
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Chromosome
messages: Induced at the onset of meiosis I and reaches a maximum level during pachytene (at protein level).
messages: Required for the pachytene checkpoint, the meiotic checkpoint that prevents chromosome segregation when defects in recombination and synaptonemal complex formation occurred. Represses meiotic recombination in the rDNA, probably by excluding the meiosis-specific protein HOP1 from the nucleolar region.
messages: nucleolus

559292:YNL176C
gene id: 559292:YNL176C
uniprot id: P53882
names: Disruption Phenotype
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA7 family.
messages: During G2 phase of cell cycle. Promoter is bound by the FKH2 transcription factor.
messages: Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.
messages: Vacuole membrane

559292:YHR035W
gene id: 559292:YHR035W
uniprot id: P38769
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for SAR1 (PubMed:24947508). Contrary to its SEC23 homolog, NEL1 does not associate with SEC24 and its homologs, nor does it associate with the COPII components, suggesting that it is unlikely that NEL1 functions as a structural component of the vesicle coat machinery (PubMed:24947508). May function as a signaling molecule (PubMed:24947508).
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: Cytoplasm
messages: Leads to a significant growth defect in the temperature-sensitive SAR1-D32G mutant background.
messages: Nucleus
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YGL091C
gene id: 559292:YGL091C
uniprot id: P52920
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.
messages: Nucleus

559292:YAR042W
gene id: 559292:YAR042W
uniprot id: P35845
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSBP family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with NVJ1 (PubMed:15367582, PubMed:28319008). Interacts with the AAA ATPase AFG2; regulates OSH1 membrane association. AFG2 is required for membrane dissociation of OSH1 (Probable). Interacts with SCS2 (PubMed:12727870).
messages: Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:8017104, PubMed:11238399, PubMed:15173322). Involved in non-vesicular transport of ergosterol and PI(4)P at the NVJ. Binds sterol and PI4P in a mutually exclusive manner (PubMed:28319008). May be involved in formation of PMN vesicles by altering the membrane lipid composition (PubMed:15173322).
messages: Nucleus outer membrane
messages: The FFAT (two phenylalanines in an acidic tract) motif is required for interaction with SCS2 and is required for targeting the protein to the ER.
messages: The OSBP-related domain (ORD) mediates binding of sterols and phospholipids. It displays an incomplete beta-barrel containing a central hydrophobic tunnel that can accommodate a single lipid molecule with a flexible lid covering the tunnel entrance. The ORD can bind two membranes simultaneously. It has at least two membrane-binding surfaces; one near the mouth of the lipid-binding pocket and a distal site that can bind a second membrane. These structural features correlate with the phosphatidylinositol 4-phosphate (PI(4)P)-coupled lipid transport optimized in closely apposed membranes, such as organelle contact sites. The lipid transfer cycle starts from the association of the LTP with a donor membrane, which accompanies conformational changes that uncover the ligand-binding pocket. The tunnel opening is generally mediated by displacement of the lid covering the binding pocket allowing uptake or release of a lipid molecule. The LTPs extract the lipid from the membrane by providing a hydrophobic environment as well as specific interaction. Dissociation from the donor membrane shifts the conformation to a closed form. Then, the LTPs loaded with a cargo lipid diffuse through the aqueous phase. Lid opening may be induced by the interaction of a hydrophobic side of the lid with the target membranes.
messages: The PH domain strongly binds to phosphoinositides and is required for targeting the protein to the late Golgi membranes.
messages: The ankyrin repeats are required for targeting the protein to the NV junction by interacting with NVJ1.
messages: Vacuole membrane

559292:YOR119C
gene id: 559292:YOR119C
uniprot id: Q12196
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Phosphorylated by casein kinase II (CK2). Phosphorylation by CK2 stimulates RIO1 kinase activity and targets it for degradation at the G1/S transition of the cell cycle.
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Can use both Mg(2+) and Mn(2+) in vitro and shows higher activity with Mn(2+) but Mg(2+) is likely to be the in vivo cofactor.
messages: Cytoplasm
messages: Interacts with CKA2.
messages: Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA. Required for the final steps of cytoplasmic maturation of the 40S ribosomal subunit. The association with the very late 40S subunit intermediate seems to follow RIO2 association with precursors of the 40S subunit and may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. Has a role in the cell cycle where it is required for entrance into S-phase and in the control of the onset of anaphase. Appears to also be involved in the maintenance of chromosome stability and correct mitotic segregation.

559292:YGR106C
gene id: 559292:YGR106C
uniprot id: P53262
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:29526695). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:29526695). Functions with VMA21 in assembly of the V0 complex (PubMed:18799613).
messages: Belongs to the VOA1 family.
messages: Endoplasmic reticulum membrane
messages: Present with 12764 molecules/cell in log phase SD medium.
messages: Reduces association of VMA6 with the V-type proton ATPase (PubMed:29526695). Decreases VPH1 protein level (PubMed:29526695).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:29526695). Interacts with VMA21 (PubMed:18799613). Associates with the assembling V0 complex (PubMed:18799613).
messages: Vacuole membrane

559292:YER096W
gene id: 559292:YER096W
uniprot id: P39000
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKT5 family.
messages: Cytoplasm
messages: Cytoplasmic granule membrane
messages: During sporulation and at high pH.
messages: Required for the activation of chitin synthase III (CHS3) activity during the sporulation process.

559292:YAR066W
gene id: 559292:YAR066W
uniprot id: P0CX18
uniprot id: P0CX19
names: Subcellular Location Annotation
messages: Cell membrane

559292:YGR092W
gene id: 559292:YGR092W
uniprot id: P22204
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Bud neck
messages: Interacts with MOB1. MOB1-binding is required for a late mitotic event.
messages: Kinase activity is regulated by BUB2, CDC15 and CDC5, and is maximal during nuclear division. CDK1 kinase inhibits cellular DBF2-MOB1 kinase activity via phosphorylation of both CDC15 and MOB1.
messages: Nucleus
messages: Periodically expressed in the cell cycle, with a peak before the onset of budding.
messages: Phosphorylation of Ser-374 and Thr-544 by CDC15 is essential for activation of DBF2 kinase activity.
messages: Present with 3500 molecules/cell in log phase SD medium.
messages: Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Phosphorylates CHS2 to regulate its dynamics and chitin synthesis at the division site during cytokinesis. Coordinates septin and actomyosin ring (AMR) functions during cytokinesis through the phosphorylation of HOF1. In complex with MOB1, phosphorylates CDC14 at sites adjacent to its nuclear localization sequence, thereby retaining CDC14 in the cytoplasm. Binds also to SWI5 and CLB2 mRNAs cotranscriptionally to regulate their decay. In the nucleus, the DBF2-MOB1 complex regulates passenger protein localization during anaphase. Mediates sorbic acid stress tolerance through promoting vacuolar H(+)-ATPase function, probably through phosphorylation of VMA1 and VMA2 subunits.
messages: spindle pole body

559292:YJR029W
gene id: 559292:YJR029W
uniprot id: P47100
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YJR028W ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YKR031C
gene id: 559292:YKR031C
uniprot id: P36126
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Activity is dependent of phosphatidylinositol 4,5-bisphosphate and the regulator SRF1. Inhibited by magnesium.
messages: Belongs to the phospholipase D family.
messages: Interacts with SRF1.
messages: Present with 49 molecules/cell in log phase SD medium.
messages: Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. PLD activity is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth.

559292:YJR129C
gene id: 559292:YJR129C
uniprot id: P47163
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
messages: Cytoplasm
messages: Increases sensitivity to antibiotics that target translation and decreases translational fidelity.
messages: Present with 1550 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono-, di- and trimethylates elongation factor 2 (EFT1/EFT2) at 'Lys-509'.

559292:YKL144C
gene id: 559292:YKL144C
uniprot id: P35718
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC25/RPC8 and RPC17/RPC9 form a Pol III subcomplex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation.
messages: Nucleus
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YKL187C
gene id: 559292:YKL187C
uniprot id: P34231
names: PTM
names: Subcellular Location Annotation
messages: Mitochondrion
messages: N-glycosylated.

559292:YBR298C
gene id: 559292:YBR298C
uniprot id: P38156
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: By maltose and maltotriose. Repressed by glucose.
messages: High-affinity uptake of maltose and maltotriose. Also transports turanose but not alpha-methylglucoside, melezitose or trehalose.
messages: Membrane

559292:YCL051W
gene id: 559292:YCL051W
uniprot id: P25579
names: Function
names: PTM
messages: Overexpression affects chitinase expression, cell separation and budding pattern, and increases trehalose accumulation and heat resistance by inhibiting protein kinase CBK1. Overexpression also suppresses temperature-induced hyperosmosensitivity and sensitivity to cell wall degrading enzymes. Overexpression of both LRE1 and PBN1 confers resistance to laminarinase.
messages: Phosphorylated by CDC28/CDK1.

559292:YGL096W
gene id: 559292:YGL096W
uniprot id: P53147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/CUP9 homeobox family.
messages: Nucleus

559292:YNL185C
gene id: 559292:YNL185C
uniprot id: P53875
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:9151978). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins (PubMed:24675956).
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 3200 molecules/cell in log phase SD medium.

559292:YMR017W
gene id: 559292:YMR017W
uniprot id: Q04359
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Interacts with the t-SNARE SSO1 and the v-SNARE SNC2.
messages: Prospore membrane
messages: Required to maintain the prospore membrane to the nucleus during sporulation in order to capture the daughter nuclei and form the spores. Mediates the fusion of exocytic vesicles with the plasma membrane during sporulation through its interactions with the t-SNARE SSO1 and v-SNARE SNC2.
messages: The inhibitory region sequesters the protein in the nucleus.
messages: The positive regulatory region is essential and contains an amphipathic helix with hydrophobic and positive charged faces involved in the localization of the protein to the membranes through its binding to phospholipids.

559292:YBL069W
gene id: 559292:YBL069W
uniprot id: P35183
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts with PMA1.
messages: Late endosome membrane
messages: Lipid raft-associated protein involved in the targeting of PMA1 from Golgi to the plasma membrane (PubMed:7822420, PubMed:11739806). May induce clustering of PMA1, which facilitates partition of PMA1 into lipid rafts after leaving the ER and its transport to the cell surface (PubMed:11739806).
messages: Membrane raft

559292:YFR032C-A
gene id: 559292:YFR032C-A
uniprot id: P05747
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL29 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 51100 molecules/cell in log phase SD medium.

559292:YOR065W
gene id: 559292:YOR065W
uniprot id: P07143
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). CYT1 interacts with COX5A at the CIII-CIV interface (PubMed:30598554).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c (PubMed:18390544).
messages: Mitochondrion inner membrane
messages: Present with 39900 molecules/cell in log phase SD medium.

559292:YIL010W
gene id: 559292:YIL010W
uniprot id: P40553
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.
messages: During the diauxic shift. In response to oxidative stress.
messages: Monomer.
messages: Nucleus
messages: Present with 1840 molecules/cell in log phase SD medium.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen peroxide. Acts as an antioxidant necessary for stationary phase survival.
messages: telomere

559292:YOR298W
gene id: 559292:YOR298W
uniprot id: Q08750
names: Function
names: Subcellular Location Annotation
messages: Involved in the organization of the outer spore wall layers and especially in the assembly of the chitosan layer.
messages: Membrane

559292:YGR096W
gene id: 559292:YGR096W
uniprot id: P53257
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Expression is regulated by carbon source, with very low expression with succinate, acetate, ethanol or pyruvate as carbon source.
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

559292:YBR251W
gene id: 559292:YBR251W
uniprot id: P33759
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uS3m, uS4m and uS5m form the narrow entry site of the mRNA channel.
messages: Mitochondrion
messages: Present with 6680 molecules/cell in log phase SD medium.

559292:YGR237C
gene id: 559292:YGR237C
uniprot id: P50089
names: Miscellaneous
messages: Present with 1050 molecules/cell in log phase SD medium.

559292:YFL002W-A
gene id: 559292:YFL002W-A
uniprot id: P0CX63
uniprot id: P0CX64
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YFL002W-B ORF.
messages: Produced by +1 ribosomal frameshifting between codon Leu-431 and Gly-432 of the YGR161W-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty2 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YKR057W
gene id: 559292:YKR057W
uniprot id: P0C0V8
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (PubMed:14627813).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatB.
messages: Present with 27400 molecules/cell in log phase SD medium.
messages: Reduction in growth rate, a decrease in free 40S subunits, an increase in the amount of free 60S subunits and a decrease in polysome size.
messages: There are 2 genes for eS21 in yeast.

559292:YNL140C
gene id: 559292:YNL140C
uniprot id: P53910
names: Miscellaneous
messages: Present with 1590 molecules/cell in log phase SD medium.

559292:YCL010C
gene id: 559292:YCL010C
uniprot id: P25554
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF29 family.
messages: Chromatin reader component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK (PubMed:10026213, PubMed:15647753, PubMed:21685874, PubMed:24307402). In the SAGA complex, SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:21685874). SGF29 is also required for heterochromatin boundary formation function (PubMed:24307402). SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes At the promoters, SAGA is required for recruitment of the basal transcription machinery (PubMed:10026213). It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8) (PubMed:10026213). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:10026213). SLIK is proposed to have partly overlapping functions with SAGA (PubMed:15647753). It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus (PubMed:15647753).
messages: Component of the 1.8 MDa SAGA complex, which consists of at least of TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Interacts with dimethylated and trimethylated 'Lys-4' of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3). Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9.
messages: Nucleus
messages: Present with 1750 molecules/cell in log phase SD medium.
messages: The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me).

559292:YPL271W
gene id: 559292:YPL271W
uniprot id: P21306
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 4280 molecules/cell in log phase SD medium.

559292:YOR003W
gene id: 559292:YOR003W
uniprot id: P25036
names: Function
names: Induction
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Serine protease with unknown substrate.
messages: Undergoes rapid but transient induction upon transfer to sporulation medium.

559292:YOL103W-A
gene id: 559292:YOL103W-A
uniprot id: Q92392
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-OL is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YJR110W
gene id: 559292:YJR110W
uniprot id: P47147
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Exhibits increased phosphatidylinositol 3-monophosphate (PI3P) level.
messages: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P). Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity.
messages: Present with 1080 molecules/cell in log phase SD medium.

559292:YML027W
gene id: 559292:YML027W
uniprot id: P34161
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Expressed from late G1 phase.
messages: Interacts with MCM1.
messages: Nucleus
messages: Present with 861 molecules/cell in log phase SD medium.
messages: Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during the interval from late G1 to M phases. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. In vitro, is capable of binding to the DNA of the leucine tRNA gene.
messages: Transcriptionally activated by SWI4-SWI6 heterodimer.

559292:YIR001C
gene id: 559292:YIR001C
uniprot id: P40561
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 6490 molecules/cell in log phase SD medium.
messages: mRNA-binding protein that may play a role in modulating the expression of cytoplasmic mRNA.

559292:YDL054C
gene id: 559292:YDL054C
uniprot id: Q07376
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane.
messages: Vacuole membrane

559292:YMR178W
gene id: 559292:YMR178W
uniprot id: Q03219
names: Miscellaneous
messages: Present with 3890 molecules/cell in log phase SD medium.

559292:YKL220C
gene id: 559292:YKL220C
uniprot id: P36033
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: By transcription factors AFT1 and AFT2 upon iron deprivation.
messages: Cell membrane
messages: Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake.

559292:YKL028W
gene id: 559292:YKL028W
uniprot id: P36100
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE alpha subunit family.
messages: Nucleus
messages: Present with 35900 molecules/cell in log phase SD medium.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
messages: TFIIE is a tetramer of two alpha (TFA1) and two beta (TFA2) subunits.

559292:YPR175W
gene id: 559292:YPR175W
uniprot id: P24482
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As accessory component of the DNA polymerase epsilon complex participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Cytoplasm
messages: DNA polymerase epsilon is a heterotetramer consisting of POL2, DPB2, DPB3 and DPB4.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus
messages: Phosphorylated in a cell cycle dependent manner during late G1 phase. Phosphorylation may facilitate the interaction with POL2 or the activity of DNA polymerase II. Phosphorylation is independent of DNA replication but dependent upon CDC28 in vivo. Both Ser-141 and Ser-613 are phosphorylated in vivo, but in vitro only Ser-141 is phosphorylated by CDC28.
messages: Present with 3110 +/- 251 molecules/cell in log phase SD medium.

559292:YDR539W
gene id: 559292:YDR539W
uniprot id: Q03034
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family. UbiD-like/FDC subfamily.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites (PubMed:20471595, PubMed:25647642). Not essential for ubiquinone synthesis (PubMed:20471595).
messages: Cytoplasm
messages: Homodimer (PubMed:25862228). May form higher order oligomers (PubMed:25647642).
messages: Present with 861 molecules/cell in log phase SD medium.

559292:YEL036C
gene id: 559292:YEL036C
uniprot id: P32629
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANP1/MMN9/VAN1 family.
messages: Component of the M-Pol II complex composed of ANP1, MNN9, MNN10, MNN11 and HOC1.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in the organization of the secretory pathway. Required to maintain a functional Golgi apparatus.
messages: The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.

559292:YPL236C
gene id: 559292:YPL236C
uniprot id: Q12003
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Leads to internal accumulation of precursor CPY.
messages: Serine/threonine-protein kinase involved in vacuolar processing and morphology.
messages: Vacuole membrane

559292:YMR081C
gene id: 559292:YMR081C
uniprot id: P32488
names: Function
names: Induction
names: Similarity
messages: Belongs to the ISF1/MBR1 family.
messages: Could influence the NAM7/UPF1 function, possibly at the level of mRNA turnover. Participates in mitochondrial biogenesis.
messages: Repressed by glucose. Cotranscribed with NAM7 in the absence of CYP1.

559292:YOR017W
gene id: 559292:YOR017W
uniprot id: P32606
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET127 family.
messages: Could be a component of the mitochondrial translation system with a role in promoting accuracy of translational initiation.
messages: Mitochondrion
messages: Present with 1730 molecules/cell in log phase SD medium.

559292:YMR211W
gene id: 559292:YMR211W
uniprot id: Q03652
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Cytoplasm
messages: Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
messages: Mitochondrion

559292:YOR151C
gene id: 559292:YOR151C
uniprot id: P08518
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerases II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw. The jaws are thought to grab the incoming DNA template. The fork loop 1 (RPB2) interacts with the RNA-DNA hybrid, possibly stabilizing it.
messages: Nucleus
messages: Present with 18700 molecules/cell in log phase SD medium.
messages: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits.

559292:YPL208W
gene id: 559292:YPL208W
uniprot id: Q08961
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 4800 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates ribosomal protein S18 (RPS18A and RPS18B) at 'Lys-48' and dimethylates ribosomal protein L23 (RPL23A and RPL23B) at 'Lys-106' and 'Lys-110'.

559292:YDL113C
gene id: 559292:YDL113C
uniprot id: Q07528
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Endosome membrane
messages: Forms a complex with SNX4 and ATG17.
messages: Preautophagosomal structure membrane
messages: Present with 358 molecules/cell in log phase SD medium.
messages: Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway. Required for proper sorting of the v-SNARE protein SNC1.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization of ATG20 to the perivacuolar punctate structures.

559292:YFL023W
gene id: 559292:YFL023W
uniprot id: P43573
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Deletion leads to a K1 killer toxin hypersensitivity.
messages: Involved in gene expression controlled by TOR kinase and nutrient signaling. May also be involved in positioning the proximal bud pole signal.
messages: Present with 1300 molecules/cell in log phase SD medium.

559292:YGR070W
gene id: 559292:YGR070W
uniprot id: P53046
names: Function
messages: Stimulates the exchange of RHO1 GDP-bound form into GTP-bound form.

559292:YHR114W
gene id: 559292:YHR114W
uniprot id: P38822
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BZZ1 family.
messages: Interacts with LAS17 and MYO5.
messages: Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.
messages: Present with 5440 molecules/cell in log phase SD medium.
messages: actin patch

559292:YER003C
gene id: 559292:YER003C
uniprot id: P29952
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: By D-mannose.
messages: Can be inhibited by an excess of zinc.
messages: Cytoplasm
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
messages: Monomer.
messages: Present with 5220 molecules/cell in log phase SD medium.

559292:YAR023C
gene id: 559292:YAR023C
uniprot id: D6VPM8
names: Caution
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Could be the product of a pseudogene. This is the C-terminal part of a DUP240 protein in strain S288c due to a naturally occurring frameshift at position 8 compared to other strains. A complete sequence for YAR023C can be found in other strain backgrounds (AC P0CI38).
messages: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.
messages: Membrane

559292:YNR073C
gene id: 559292:YNR073C
uniprot id: P0CX08
uniprot id: P0CX09
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.
messages: Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Rescues temperature-sensitivity of MPT5 deletion.
messages: There are two genes for this mannitol dehydrogenase in yeast, DSF1 and YNR073C.

559292:YGL120C
gene id: 559292:YGL120C
uniprot id: P53131
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
messages: Component of the NTR complex (NTC-related complex), composed of NTR1, NTR2 and PRP43. Interacts with NTR1 and NTR2. Interacts with SPP382.
messages: Nucleus
messages: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.
messages: Present with 16900 molecules/cell in log phase SD medium.

559292:YOR356W
gene id: 559292:YOR356W
uniprot id: Q08822
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Belongs to the ETF-QO/FixC family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Displays higher growth rate and higher sensitivity to superoxide and heat stress, on nonfermentable carbon sources. Leads to decreased intracellular oxidation upon heat shock.
messages: Mitochondrion inner membrane
messages: Present with 3320 molecules/cell in log phase SD medium.

559292:YBR125C
gene id: 559292:YBR125C
uniprot id: P38089
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YBR023C
gene id: 559292:YBR023C
uniprot id: P29465
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chitin synthase family. Class IV subfamily.
messages: Bud neck
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Decreases cell wall chitin level (PubMed:28346351). Resistance to Calcofluor White (cell wall stressor) (PubMed:28346351). Decreases conjugation frequency (PubMed:9234668).
messages: Glycosylated.
messages: Homodimer (PubMed:28346351). May form higher order oligomers (PubMed:28346351). Seems to interact with BNI4 and SKT5 which link CHS3 to septins (PubMed:9314530, PubMed:28346351).
messages: Palmitoylated by PFA4; required for proper export from the ER.
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (Probable) (PubMed:9760183). Appears to be responsible for synthesis of the majority of the chitin found in the cell wall periphery (PubMed:2050738). It is involved in the synthesis of the chitin ring that forms in the cell wall just before bud emergence (PubMed:2050738). This ring remains at the base of the bud as the bud grows and ultimately forms part of the bud scar marking the division site on the mother cell (PubMed:2050738). Also catalyzes the synthesis of chitin laid down during mating and spore cell-wall synthesis (PubMed:2050737, PubMed:2050738, PubMed:1293886).
messages: Present with 1510 molecules/cell in log phase SD medium.
messages: Was originally thought that the N- and C-termini were extracellular (PubMed:16847258). However, more recent data suggests that the N- and C-termini are cytoplasmic (PubMed:28346351).

559292:YKL043W
gene id: 559292:YKL043W
uniprot id: P36093
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EFG1/PHD1/stuA family.
messages: Nucleus
messages: Present with 1420 molecules/cell in log phase SD medium.
messages: Putative transcription factor that functions in pseudohyphal growth.

559292:YMR132C
gene id: 559292:YMR132C
uniprot id: P40206
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC25 family.
messages: Cytoplasm
messages: Present with 3060 molecules/cell in log phase SD medium.

559292:YFR053C
gene id: 559292:YFR053C
uniprot id: P04806
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:332086). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:332086).
messages: Homodimer.
messages: In yeast there are three glucose-phosphorylating isoenzymes, designated hexokinase I, II and glucokinase.
messages: Present with 40800 molecules/cell in log phase SD medium.
messages: Subject to allosteric control. Substrate inhibition by ATP.

559292:YOL089C
gene id: 559292:YOL089C
uniprot id: Q12180
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 238 molecules/cell in log phase SD medium.
messages: Putative transcription factor involved in halotolerance.

559292:YGL084C
gene id: 559292:YGL084C
uniprot id: P53154
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed constitutively.
messages: Interacts with mitochondrial outer membrane voltage-dependent anion channel (VDAC) POR1.
messages: Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Acts only on GPI-anchored proteins, but not on free GPI lipids. Acts as an acyltransferase for GPI anchors that adds C26 fatty acids to the sn2 position of lyso-PI-containing GPI anchors. PER1 first deacylates, GUP1 subsequently reacylates the anchor lipid, thus replacing a shorter fatty acid (C16:0 or C18:0) by C26:0 (PubMed:16597698, PubMed:18036137). Also involved in lipid metabolism, having profound effects on sphingolipid-sterol-ordered domains integrity and assembly (PubMed:18786505). Together with GUP2, has an influence on the chemical composition of the yeast extracellular matrix (yECM) in yeast multicellular aggregates, such as biofilms and colonies (PubMed:25589358). Involved in cell integrity and apoptosis (PubMed:22617017, PubMed:30184078).
messages: Mitochondrion membrane
messages: Present with 672 molecules/cell in log phase SD medium.
messages: Results in an increase in triglyceride (TG) synthesis with a concomitant decrease in phospholipid (PL) synthesis and exhibits an altered plasma membrane lipid composition (PubMed:10747858). Shows defects in cell wall assembly and stability and abnormal cell wall morphology (PubMed:17042752). Deficient in GPI anchor remodeling, mutant cells only contain the primary, unremodeled phosphatidylinositol (PI) and are unable to attach remodeled PI or ceramides to the anchor (PubMed:16597698). Defective in sterol lipid distribution (PubMed:18786505).
messages: Was originaly thought to be involved in active uptake of glycerol driven by electrogenic proton symport (PubMed:10931309), but has later been shown to be an acyltransferase and that effects on glycerol transport may be indirect (PubMed:10694878, PubMed:15381122).

559292:YPR104C
gene id: 559292:YPR104C
uniprot id: P39521
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Controls the pre-rRNA processing machinery in conjunction with IFH1. Presumably acts as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator.
messages: Nucleus
messages: Present with 639 molecules/cell in log phase SD medium.

559292:YOR370C
gene id: 559292:YOR370C
uniprot id: P32864
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Rab GDI family.
messages: Present with 23800 molecules/cell in log phase SD medium.
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

559292:YBR198C
gene id: 559292:YBR198C
uniprot id: P38129
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TAF5 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.
messages: Nucleus
messages: Present with 14834 (+/-203) molecules/cell in log phase SD medium.
messages: The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. Component of the 1.8 MDa SAGA complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1. TAF5, TAF6, TAF9, TAF19, TAF12 and ADA1 seem to be present in 2 copies. SAGA is built of 5 distinct domains with specialized functions. Domain I (containing TRA1) probably represents the activator interaction surface. Domain II (containing TAF5 and TAF6, and probably TAF9 and TAF10), domain III (containing GCN5, TAF10, SPT7, TAF5 and ADA1, and probably ADA2, ADA3 and TAF12), and domain IV (containing HFI1/ADA1 and TAF6, and probably TAF9) are believed to play primarily an architectural role. Domain III also harbors the HAT activity. Domain V (containing SPT3 and SPT20, and probably SPT8) represents the TBP-interacting module, which may be associated transiently with SAGA. Component of the SALSA complex, which consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3. Component of the SLIK complex, which consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9.

559292:YOL043C
gene id: 559292:YOL043C
uniprot id: Q08214
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage as well as abasic sites. Can also repair the oxidation products of 8-oxoguanine.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Constitutively expressed.
messages: Greatly increases spontaneous and hydrogen peroxide-induced mutation frequency.
messages: Interacts with MLH1.
messages: Monosumoylated.
messages: Nucleus
messages: Present with 125 molecules/cell in log phase SD medium.

559292:YIL014W
gene id: 559292:YIL014W
uniprot id: P40549
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans.
messages: Present with 2310 molecules/cell in log phase SD medium.

559292:YLR285W
gene id: 559292:YLR285W
uniprot id: Q05874
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
messages: Cytoplasm
messages: Present with 7280 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha (TEF1 and TEF2), before also catalyzing the mono- and dimethylation of 'Lys-3' (PubMed:21858014, PubMed:26545399). May be involved in rDNA silencing and in lifespan determination (PubMed:12736687).
messages: Was originally thought to be a nicotinamide N-methyltransferase.

559292:YCR007C
gene id: 559292:YCR007C
uniprot id: P25354
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DUP/COS family.
messages: Interacts according to large scale protein interaction studies with MEC3 and ULP1.
messages: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.
messages: Membrane

559292:YGR157W
gene id: 559292:YGR157W
uniprot id: P05374
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
messages: Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME). Preferentially converts di-C16:1 substrates.
messages: Endoplasmic reticulum membrane
messages: Present with 1810 molecules/cell in log phase SD medium.
messages: Repressed by myo-inositol and choline.

559292:YDR362C
gene id: 559292:YDR362C
uniprot id: Q06339
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with TFC8. Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with TFC1, TFC3, TFC4 and directly with TFC8.
messages: Nucleus
messages: Present with 1130 molecules/cell in log phase SD medium.
messages: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with TFC3 in DNA binding.

559292:YLR336C
gene id: 559292:YLR336C
uniprot id: Q06132
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC22 family.
messages: Interacts with PLC1.
messages: Involved in osmoregulatory glycerol response, probably through its interaction with PLC1 which regulates the expression of GDP1.
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YPR137C-B
gene id: 559292:YPR137C-B
uniprot id: P0C2I9
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YPR137C-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YOR042W
gene id: 559292:YOR042W
uniprot id: Q08412
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 adapter and thus mediating autophagic clearance of ubiquitin conjugates under starvation conditions. The CUE5-dependent selective autophagy pathway plays an important role in clearance of cytotoxic protein aggregates. Not required for cytoplasmic to vacuole pathway (cvt), mitophagy, pexophagy, or ribophagy.
messages: Cytoplasm
messages: Interacts with ATG8 (via AIM motif), CLB2, and ubiquitin (via CUE domain).
messages: Present with 623 molecules/cell in log phase SD medium.
messages: The ATG8-interaction motif (AIM) is required for the association with ATG8.

559292:YMR202W
gene id: 559292:YMR202W
uniprot id: P32352
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG2 family.
messages: C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (Ref.5). ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (Ref.5). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto gr…
messages: Catalytic activity is inhibited by the morphilines tridemorph, fenpropimorph, and fenpropidin.
messages: Endoplasmic reticulum membrane
messages: Expression is increased during ergosterol starvation, during anaerobic growth or in the presence of SR31747A, a sterol isomerase inhibitor (PubMed:10734216). Exogenously-supplied zymosterol is entirely transformed into ergosterol, which represses ERG2 expression (PubMed:10734216). However, exogenously-supplied ergosterol does not affect ERG2 expression (PubMed:10734216).
messages: Present with 2640 molecules/cell in log phase SD medium.

559292:YNL068C
gene id: 559292:YNL068C
uniprot id: P41813
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Causes only a modest decline in CLB2 cluster genes expression, but this expression is abolished when both FKH1 and FKH2 are deleted (PubMed:10959837). Leads to a defect in silencing HMRa (PubMed:10747051). Causes a form of yeast pseudohyphal growth, when FKH2 is also deleted (PubMed:10747051). Affects cell-cycle progression and CLB2 mRNA expression (PubMed:10747051).
messages: Interacts with MCM1 (PubMed:10959837). Interacts with NDD1 (PubMed:12865300). Interacts with the origin recognition complex (ORC) composed of ORC1 to ORC6 (PubMed:22265405).
messages: Nucleus
messages: Present with 656 molecules/cell in log phase SD medium.
messages: The FHA domain is necessary for the interaction with NDD1.
messages: Transcription factor that regulates the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle (PubMed:10959837, PubMed:10894548, PubMed:10894549, PubMed:11562353, PubMed:12702877, PubMed:17283050, PubMed:24504085). The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20 as well as SWI5 and ACE2, transcription factors required for the subsequent temporal wave of cell cycle regulated gene expression in the M/G1 phase interval (PubMed:10959837, PubMed:10894548, PubMed:11562353). Involved in HMRa silencing (PubMed:10747051). FKH1 and FKH2 associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing (PubMed:12702877). Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation (PubMed:22438832). FKH1 and FKH2 function also in controlling yeast cell morphology by preventing preudohyphal growth (PubMed:10747051, PubMed:10894548). Acts as a rate-limiting replication origin activator via its interactin with the origin recognition complex (ORC) (PubMed:22265405, PubMed:26728715).
messages: cytosol

559292:YNL293W
gene id: 559292:YNL293W
uniprot id: P48566
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Bud
messages: Bud neck
messages: Cytoplasm
messages: Present with 178 molecules/cell in log phase SD medium.
messages: Regulates exocytosis by functioning as a GAP for SEC4. Stimulates specifically the GTPase activity of YPT6. Also required for efficient polarization of the actin patches.

559292:YCR024C-A
gene id: 559292:YCR024C-A
uniprot id: P32903
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Monomer and homodimer. Associated with the 100 kDa subunit of the plasma membrane H(+)-ATPase.
messages: Present with 124000 molecules/cell in log phase SD medium.

559292:YKR068C
gene id: 559292:YKR068C
uniprot id: P36149
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.
messages: Preautophagosomal structure
messages: Present with 2370 molecules/cell in log phase SD medium.
messages: cis-Golgi network

559292:YMR030W-A
gene id: 559292:YMR030W-A
uniprot id: Q3E760
names: Subcellular Location Annotation
messages: Membrane

559292:YPL095C
gene id: 559292:YPL095C
uniprot id: Q02891
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
messages: Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.
messages: Present with 573 molecules/cell in log phase SD medium.

559292:YDR457W
gene id: 559292:YDR457W
uniprot id: Q03280
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.
messages: Interacts with the ADA3/NGG1 subunit of the SAGA complex. Interacts with KRR1.
messages: Present with 350 molecules/cell in log phase SD medium.
messages: Probable ubiquitin ligase protein involved in many cellular processes, such as transcription regulation, maintenance of nuclear structure, cell cycle, mRNA export and rRNA maturation. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Involved in transcription regulation by interacting, and probably mediating, ubiquitination of some subunit of the SAGA complex. Required for SPT7 ubiquitination. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins. Required for the shuttling of hnRNP protein NAB2, probably by mediating ubiquitination of a protein associated with NAB2. Also required for full induction of the general stress and heat-shock responses. Involved in 18S rRNA maturation by affecting several early steps in the rRNA processing pathway.
messages: nucleolus

559292:YCL057W
gene id: 559292:YCL057W
uniprot id: P25375
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Could be involved in late stage of protein degradation.
messages: Cytoplasm
messages: Present with 8910 molecules/cell in log phase SD medium.

559292:YLR194C
gene id: 559292:YLR194C
uniprot id: Q05777
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall biogenesis protein that participates in the organization of the beta-glucan assembly (PubMed:27246500). Involved in the mechanism responsible for cell tolerance to polyhexamethylene biguanide (PHMB), an antifungal agent (PubMed:27246500).
messages: Positively regulated by cell integrity signaling through MPK1 in response to cell wall perturbation (PubMed:10594829, PubMed:11016834). Induction is dependent on transcription factor RLM1 (PubMed:10594829, PubMed:11016834). Expression is also up-regulated 7-fold upon exposure to polyhexamethylene biguanide (PHMB) (PubMed:27246500).
messages: Present with 688 molecules/cell in log phase SD medium.
messages: Reduces significantly the growth rate of cells exposed to polyhexamethylene biguanide (PHMB) (PubMed:27246500). Leads to increased resistance to zymolyase treatment, indicating alterations in the beta-glucan network (PubMed:27246500).

559292:YDR296W
gene id: 559292:YDR296W
uniprot id: Q06630
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL67 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:24675956). mL67/MHR1 also has extraribosomal functions, being involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (PubMed:11121487, PubMed:12198175, PubMed:14565971, PubMed:16337661, PubMed:7664749, PubMed:9736700). mL67/MHR1 also acts as transcription factor involved in regulation of RNA polymerase II-dependent transcription (PubMed:12034822).
messages: Mitochondrion
messages: Nucleus
messages: Present with 2610 molecules/cell in log phase SD medium.

559292:YIR033W
gene id: 559292:YIR033W
uniprot id: P40578
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YDR422C
gene id: 559292:YDR422C
uniprot id: P32578
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Promotes the PKA-regulated relocalization of the SNF1 kinase complex to the vacuolar membrane in response to various types of carbon stress.
messages: Component of the SNF1 kinase complex, a heterotrimeric complex composed of the catalytic alpha subunit SNF1, one of the three related beta subunits SIP1, SIP2 or GAL83, and the regulatory gamma subunit SNF4. The beta subunit serves as a bridge between the catalytic and the regulatory subunit. Interacts (via KIS domain) with SNF1. Interacts (via ASC domain) with SNF4.
messages: Cytoplasm
messages: Phosphorylated by SNF1 in vitro.
messages: Present with 623 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YMR271C
gene id: 559292:YMR271C
uniprot id: P30402
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Present with 815 molecules/cell in log phase SD medium.
messages: There are two genes coding for OPRT in yeast.

559292:YNL129W
gene id: 559292:YNL129W
uniprot id: P53915
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the uridine kinase family. NRK subfamily.
messages: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
messages: Present with 1460 molecules/cell in log phase SD medium.

559292:YER173W
gene id: 559292:YER173W
uniprot id: P32641
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rad17/RAD24 family.
messages: Component of the RAD24-RFC complex which consists of RAD14, RFC2, RFC3, RFC4 and RFC5 and associates with the checkpoint clamp DDC1:MEC3:RAD17 complex. RAD24 interacts with ECO1.
messages: Nucleus
messages: Participates in checkpoint pathways arrest of the cell cycle, a mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Regulates the DNA damage checkpoint pathway throughout the cell cycle, when associated with RCF5. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YNR019W
gene id: 559292:YNR019W
uniprot id: P53629
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Present with 279 molecules/cell in log phase SD medium.
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

559292:YER116C
gene id: 559292:YER116C
uniprot id: P40072
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:18032921, PubMed:17669696, PubMed:17848550, PubMed:18499666, PubMed:18948542, PubMed:31015336). The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921). The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795). The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440). The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737). During replication, the complex helps to prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698). The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332). It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921). Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336).
messages: Component of the heterodimeric SUMO-targeted ubiquitin ligase (STUbL) complex composed of SLX5 and SLX8.
messages: Leads to the persistence of YEN1 foci.
messages: Nucleus
messages: kinetochore

559292:YNR039C
gene id: 559292:YNR039C
uniprot id: P53735
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

559292:YDL143W
gene id: 559292:YDL143W
uniprot id: P39078
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.
messages: Present with 5530 molecules/cell in log phase SD medium.

559292:YCL029C
gene id: 559292:YCL029C
uniprot id: P11709
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 300 molecules/cell in log phase SD medium.
messages: Required for nuclear fusion, chromosome disjunction, and nuclear segregation during mitosis. Probably required for the formation or stabilization of microtubules during mitosis and for spindle pole body fusion during conjugation.
messages: spindle
messages: spindle pole body

559292:YLR303W
gene id: 559292:YLR303W
uniprot id: P06106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Also catalyzes the conversion of O-acetylserine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway (PubMed:7765825, PubMed:4609980, PubMed:795806). However, it seems that in S.cerevisiae cysteine biosynthesis occurs exclusively through the cystathionine pathway and not via direct incorporation of sulfur into OAS (PubMed:1732168). It therefore has no metabolic role in cysteine biosynthesis and may only have a regulatory role controlling OAS levels (PubMed:12586406).
messages: Cytoplasm
messages: Homotetramer.

559292:YER057C
gene id: 559292:YER057C
uniprot id: P40037
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Present with 672 molecules/cell in log phase SD medium.

559292:YDL101C
gene id: 559292:YDL101C
uniprot id: P39009
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylation increases in response to DNA damage.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
messages: Interacts with the PAB-dependent poly(A)-nuclease (PAN) complex regulatory subunit PAN3 via its forkhead-associated (FHA) domain.
messages: Nucleus
messages: Present with 3480 molecules/cell in log phase SD medium.
messages: Transducer of the DNA damage signal. Phosphorylates SML1 on serine residues. Cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.

559292:YIL159W
gene id: 559292:YIL159W
uniprot id: P40450
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the formin homology family. BNI1 subfamily.
messages: Interacts with profilin at the FH1 domain.
messages: May organize microtubules by mediating spindle positioning and movement in the budding process. Potential target of the RHO family members (By similarity).
messages: Present with 259 molecules/cell in log phase SD medium.
messages: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).

559292:YOR268C
gene id: 559292:YOR268C
uniprot id: Q08734
names: Subcellular Location Annotation
messages: Membrane

559292:YAL060W
gene id: 559292:YAL060W
uniprot id: P39714
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: NAD-dependent (R,R)-butanediol dehydrogenase which catalyzes oxidation of (R,R)-butane-2,3-diol to (3R)-acetoin, of meso-butanediol to (3S)-acetoin, and reduction of acetoin. Allows the use of 2,3-butanediol as an aerobic carbon source.
messages: Present with 8730 molecules/cell in log phase SD medium.

559292:YMR164C
gene id: 559292:YMR164C
uniprot id: Q03825
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MSS11 family.
messages: Cytoplasm
messages: Interacts with FLO8, STE12 and TEC1.
messages: Nucleus
messages: Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.

559292:YDR123C
gene id: 559292:YDR123C
uniprot id: P26798
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus
messages: Positive regulatory factor required for depression of the coregulated phospholipid biosynthetic enzymes. Also involved in the expression of ITR1.
messages: Present with 784 molecules/cell in log phase SD medium.

559292:YGL157W
gene id: 559292:YGL157W
uniprot id: P53111
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
messages: By furfural and 5-hydroxymethylfurfural (HMF).
messages: Cytoplasm
messages: NADPH-dependent aldehyde reductase involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Reduces commonly detected inhibitors in biomass conversion hydrolysates such as furfural, 5-hydroxymethylfurfural (HMF), cinnamic aldehyde, benzaldehyde, phenylacetaldehyde, and anisaldehyde.
messages: Nucleus

559292:YER098W
gene id: 559292:YER098W
uniprot id: P39967
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Present with 98 molecules/cell in log phase SD medium.

559292:YKL172W
gene id: 559292:YKL172W
uniprot id: P36049
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EBP2 family.
messages: Interacts with LOC1, NOP12, SIZ2, ULS1 and WSS1.
messages: Required for the processing of the 27S pre-rRNA. Probably involved in the step of the processing of the 27 SA precursor into the 27 SB intermediate.
messages: Sumoylated.
messages: nucleolus

559292:YKL092C
gene id: 559292:YKL092C
uniprot id: P33314
names: Function
names: Miscellaneous
messages: Present with 1230 molecules/cell in log phase SD medium.
messages: Stimulates the GTPase activity of BUD1/RSR1. Participates in the regulation of bud-site selection.

559292:YLR221C
gene id: 559292:YLR221C
uniprot id: Q05942
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with nucleolar pre-ribosomal particles. Interacts with DBP6. Together with DBP6, NOP8, URB1 and URB2, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.
messages: Belongs to the RSA3 family.
messages: Present with 2940 molecules/cell in log phase SD medium.
messages: Required for efficient biogenesis of the 60S ribosomal subunit.
messages: nucleolus

559292:YNL104C
gene id: 559292:YNL104C
uniprot id: P06208
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Present with 6630 molecules/cell in log phase SD medium.

559292:YGL251C
gene id: 559292:YGL251C
uniprot id: P51979
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: DNA-dependent ATPase. Required in the control of double strand breaks transition and crossover during meiosis. Unwinds DNA in the 3' TO 5' direction. Prefers single-stranded DNA.
messages: Nucleus

559292:YDR380W
gene id: 559292:YDR380W
uniprot id: Q06408
names: Biotechnology
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cytoplasm
messages: Expression is induced by the presence of aromatic amino acids and the lack of preferred nitrogen sources (e.g. ammonia, glutamine) and requires the transcription activator ARO80.
messages: Fusel oils are important flavor and aroma compounds in yeast-fermented products contributing to the quality of beverages and food. In low concentration they are generally desirable, whereas high concentrations may spoil the product. By adjusting growth conditions and substrate their production is sought to be influenced. Phenylethanol, having a rose-like aroma, is an important fragrance in the cosmetic industry and can be produced by fermentation.
messages: One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) involved in amino acid catabolism. The enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids (alpha-keto-acids). In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids derived from phenylalanine (phenylpyruvate), tryptophan (3-(indol-3-yl)pyruvate), and probably tyrosine (4-hydroxyphenylpyruvate), but also isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate) and methionine (4-methylthio-2-oxobutanoate), whereas transaminated leucine (4-methyl-2-oxopentanoate, also alpha-keto-isocaproate) is a low efficiency substrate and transaminated valine and pyruvate are no substrates. In analogy to the pyruvate decarboxylases the enzyme may in a side-reaction catalyze condensation (or carboligation) reactions leading to the formation of 2-hydroxy ketone, collectively called acyloins.
messages: Present with 6560 molecules/cell in log phase SD medium.

559292:YBR283C
gene id: 559292:YBR283C
uniprot id: P38353
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.
messages: Endoplasmic reticulum membrane
messages: Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YBR127C
gene id: 559292:YBR127C
uniprot id: P16140
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:2141385). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:2141385).
messages: Present with 131000 molecules/cell in log phase SD medium.
messages: PubMed:1371275 sequence was incorrectly thought to originate from bovine.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:25971514, PubMed:18055462, PubMed:27295975). Interacts with RAV1 and RAV2 components of the RAVE complex, which are essential for the stability and assembly of V-ATPase (PubMed:11283612).
messages: Vacuole membrane

559292:YDR484W
gene id: 559292:YDR484W
uniprot id: P39904
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS52 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts also with TLG1 and YPT6.
messages: Endosome membrane
messages: Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. May also be involved in the actin cytoskeleton organization.
messages: Present with 3130 molecules/cell in log phase SD medium.
messages: cytoskeleton
messages: trans-Golgi network membrane

559292:YCR089W
gene id: 559292:YCR089W
uniprot id: P25653
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: By mating pheromones. By cells of the opposite mating type.
messages: Membrane
messages: N-glycosylated.
messages: Required for efficient mating. Plays a role in maintenance of cell wall integrity during mating. Important for mating cell projection shape and conjugation bridge diameter. Plays a role in cell fusion and nuclear migration.
messages: cell wall

559292:YPR022C
gene id: 559292:YPR022C
uniprot id: Q12139
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YAL044W-A
gene id: 559292:YAL044W-A
uniprot id: Q3E793
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH) (PubMed:27532772). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532772). Probably acts together with the monothiol glutaredoxin GRX5, earlier than BOL3 and NFU1 in the [4Fe-4S] cluster insertion process (PubMed:27532773). Not required for [2Fe-2S] cluster insertion into mitochondrial proteins (PubMed:27532772).
messages: Belongs to the BolA/IbaG family.
messages: Interacts with GRX5.
messages: Mitochondrion matrix
messages: No visible phenotype (PubMed:27532773, PubMed:27532772). Cells lacking BOL1 and BOL3 display defects in a subset of mitochondrial [4Fe-4S] enzymes (PubMed:27532772).
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YGR102C
gene id: 559292:YGR102C
uniprot id: P53260
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.
messages: Belongs to the GatF family.
messages: Mitochondrion inner membrane
messages: Present with 172 molecules/cell in log phase SD medium.
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A (HER2), B (PET112) and F (YGR102C) subunits.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

559292:YJL106W
gene id: 559292:YJL106W
uniprot id: P32581
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Protein kinase which is essential for the initiation of meiosis and sporulation.

559292:YGL134W
gene id: 559292:YGL134W
uniprot id: P53124
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. PHO80 subfamily.
messages: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL8, negatively controls glycogen accumulation under favorable growth conditions. The PCL10-PHO85 cyclin-CDK holoenzyme has glycogen synthase kinase activity and phosphorylates and negatively regulates glycogen synthase GSY2. Also has minor GLC8 kinase activity.
messages: Cytoplasm
messages: Forms a cyclin-CDK complex with PHO85. Interacts with GSY2, independent of the presence of PHO85.
messages: Present with 217 molecules/cell in log phase SD medium.

559292:YGL248W
gene id: 559292:YGL248W
uniprot id: P22434
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-II family.
messages: Controls the level of cAMP in yeast cells, together with the high-affinity cAMP phosphodiesterase (PDE2).
messages: Present with 1400 molecules/cell in log phase SD medium.

559292:YBR158W
gene id: 559292:YBR158W
uniprot id: P38285
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AMN1 family.
messages: Cytoplasm
messages: Expressed in daughter cells after execution of mitotic exit. Expression is controlled by the ACE2 and SWI5 transcription factors.
messages: Interacts with TEM1.
messages: Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints. Acts in the daughter cell to inhibit the mitotic exit pathway once MEN has executed its function. Through its binding ability to TEM1, interferes with the TEM1-CDC5 association, required for CDC5 kinase activation and MEN activation. Required for daughter cell separation and chromosome stability. Involved in copper sensitivity.
messages: Nucleus
messages: Present with 2020 molecules/cell in log phase SD medium.

559292:YER178W
gene id: 559292:YER178W
uniprot id: P16387
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit.
messages: Mitochondrion matrix
messages: Phosphorylated at Ser-313 by pyruvate dehydrogenase kinases PKP1 (PDK1) and PKP2 (PDK2), and dephosphorylated by pyruvate dehydrogenase phosphatases PTC5 and PTC6.
messages: Present with 100000 molecules/cell in log phase SD medium.
messages: Pyruvate dehydrogenase (E1) is a tetramer of 2 alpha and 2 beta subunits. Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

559292:YML118W
gene id: 559292:YML118W
uniprot id: Q03210
names: Miscellaneous
names: Similarity
messages: Belongs to the CCR4/nocturin family.
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YOR291W
gene id: 559292:YOR291W
uniprot id: Q12697
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Confers sensitivity for growth for cadmium, manganese, nickel, selenium and iron.
messages: Vacuolar transporter which plays a role in sequestration of divalent heavy metal ions.
messages: Vacuole membrane

559292:YBR028C
gene id: 559292:YBR028C
uniprot id: P38070
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients (PubMed:11062466). Required for phosphorylation of ribosomal protein S6 (RPS6A/RPS6B) at 'Ser-232' and 'Ser-233' (PubMed:25767889).
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Cytoplasm
messages: Phosphorylated by PKA in a TORC1-dependent manner. Phosphorylation at PKA consensus sites RRxS/T decreases upon rapamycin treatment.
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YLL031C
gene id: 559292:YLL031C
uniprot id: Q07830
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Glycosylated.
messages: Involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Involved in cell wall biosynthesis.
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YPR161C
gene id: 559292:YPR161C
uniprot id: P23293
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUR kinase complex composed of SGV1/BUR1 and BUR2. Interacts with BUR2 and RBP1.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Nucleus
messages: Present with 2070 molecules/cell in log phase SD medium.
messages: Serine/threonine-protein kinase component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates 'Ser-120' of the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B, the localization of the PAF1 complex to the chromatin, and the silencing of telomeric-associated genes. Also required for histone H3 'Lys-4' trimethylation. May phosphorylate the 'Ser-5' of the RBP1 carboxy-terminal domain (CTD) repeats. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2.

559292:YJL207C
gene id: 559292:YJL207C
uniprot id: P39526
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Deletion, when combined with a conditional mutation in clathrin heavy chain or deletion of GGA genes, accentuates growth defects and increases disruption of clathrin-dependent alpha-factor maturation and transport of carboxypeptidase Y to the vacuole. Causes mislocalization of AP-1, especially in cells at high density (postdiauxic shift), but doesn't affect GGA protein distribution. Sensitive to diltiazem-HCl and hypersensitive to chlorpromazine.
messages: Golgi apparatus
messages: Interacts with the clathrin-associated adapter complex AP-1.
messages: Involved in the trans-Golgi network (TGN)-endosome transport. Important for the correct localization of the adapter protein complex AP-1.
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YBR258C
gene id: 559292:YBR258C
uniprot id: P38337
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHG1 family.
messages: Component of the COMPASS (Set1C) complex which consists of SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and SWD3(1).
messages: Nucleus
messages: Present with 1520 molecules/cell in log phase SD medium.
messages: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.

559292:YFR025C
gene id: 559292:YFR025C
uniprot id: P38635
names: Miscellaneous
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.
messages: Present with 4280 molecules/cell in log phase SD medium.

559292:YDR034C
gene id: 559292:YDR034C
uniprot id: P40971
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Activates the transcription of lysine biosynthesis genes. This activation is dependent on the inducer alpha-aminoadipate semialdehyde and repressed by lysine.
messages: Nucleus
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YDR297W
gene id: 559292:YDR297W
uniprot id: P38992
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Endoplasmic reticulum membrane
messages: Present with 54300 molecules/cell in log phase SD medium.
messages: Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Catalyzes the conversion of sphinganine to phytosphingosine in sphingolipid biosynthesis. Involved in the response to syringomycin.

559292:YLR380W
gene id: 559292:YLR380W
uniprot id: Q06705
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PITP family.
messages: Cytoplasm
messages: Endosome
messages: Forms a complex with 2 TSA2 subunits. Binds phosphatidylinositol (PtdIns).
messages: Microsome
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. Inhibits fatty acid synthase activity in response to heme depletion and oleic acid starvation, preventing saturated fatty acid (SFA) accumulation (PubMed:17803462).
messages: Present with 9600 molecules/cell in log phase SD medium.

559292:YDR261C
gene id: 559292:YDR261C
uniprot id: P52911
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
messages: Cell membrane
messages: Present with 2410 molecules/cell in log phase SD medium.

559292:YJR131W
gene id: 559292:YJR131W
uniprot id: P32906
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 47 family.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations it further trims the carbohydrates to Man(5)GlcNAc(2).
messages: No visible phenotype.
messages: Present with 8260 molecules/cell in log phase SD medium.

559292:YOR245C
gene id: 559292:YOR245C
uniprot id: Q08650
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Catalyzes the terminal and only committed step in triacylglycerol (TAG) synthesis by using diacylglycerol (DAG) and fatty acyl-CoA as substrates. Required for storage lipid synthesis. Major DAG esterifying enzyme in stationary phase when TAG production is particularly active. Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains, and in ergosterol biosynthesis (PubMed:11741946, PubMed:11751830, PubMed:11751875, PubMed:14640980, PubMed:15155725, PubMed:21321129, PubMed:32349126). Also has monoacylglycerol acyltransferase (MGAT) activity, catalyzing the acyl-CoA-dependent esterification of monoacylglycerol to diacylglycerol (PubMed:20554061). Can also utilize ceramide instead of DAG, acylating the ceramides by attaching a fatty acid to the hydroxy group on the first carbon atom of the long-chain base to produce 1-O-acylceramides (PubMed:22738231).
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Present with 907 molecules/cell in log phase SD medium.

559292:YHR012W
gene id: 559292:YHR012W
uniprot id: P38759
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the VPS29 family.
messages: Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPS29, VPS26 and VPS35.
messages: Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection.
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YPR180W
gene id: 559292:YPR180W
uniprot id: Q06624
names: Function
names: Miscellaneous
messages: Could be involved in a ubiquitin-related process important for DNA damage tolerance.
messages: Present with 7430 molecules/cell in log phase SD medium.

559292:YER161C
gene id: 559292:YER161C
uniprot id: P06843
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT2 family.
messages: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Global regulatory protein that plays positive as well as negative regulatory roles in transcription (PubMed:2072912).
messages: Interacts with tetramers formed by histone H3 and H4 (PubMed:26109053). Interacts with SAP1 and CDC23 (PubMed:8654588, PubMed:8710860). Component of the SAGA complex, a large multiprotein complex that modifies the chromatin, at least composed of SPT2, SPT7, SPT8, SPT20/ADA5, HFI1/ADA1, ADA2, ADA3/NGG1, TRA1 and GCN5 (PubMed:9885573).
messages: Nucleus
messages: Present with 1240 molecules/cell in log phase SD medium.
messages: The acidic C-terminal domain mediates interaction with histone H3/H4 complexes.

559292:YOR010C
gene id: 559292:YOR010C
uniprot id: P33890
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall.
messages: Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from a specific glutamine within the PIR1/2/3 repeat, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
messages: Induced during anaerobic growth and strongly by cold shock.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

559292:YIL094C
gene id: 559292:YIL094C
uniprot id: P40495
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Activity is repressed 4-fold by lysine.
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate.
messages: Inhibited by the reaction product NADH. Inhibited by oxalate; this is a non-competitive inhibitor.
messages: Mitochondrion
messages: Present with 19079 molecules/cell in log phase SD medium.

559292:YOR141C
gene id: 559292:YOR141C
uniprot id: Q12386
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family.
messages: Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core (By similarity).
messages: Nucleus
messages: Present with 1010 molecules/cell in log phase SD medium.
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Exhibits low basal ATPase activity, and unable to polymerize. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
messages: cytoskeleton

559292:YDR429C
gene id: 559292:YDR429C
uniprot id: Q04067
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Binds to the 18S rRNA but non-specifically (PubMed:10085088).
messages: The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.

559292:YFR037C
gene id: 559292:YFR037C
uniprot id: P43609
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and for repression of CHA1 expression.
messages: Dimerizes via the C-terminal coiled coil. Interacts directly with HTL1, NPL6, RSC6 and the N-terminus of STH1. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
messages: Nucleus
messages: Present with 3380 molecules/cell in log phase SD medium.

559292:YLR165C
gene id: 559292:YLR165C
uniprot id: Q06244
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase RluA family.
messages: Mitochondrion
messages: Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.

559292:YPR088C
gene id: 559292:YPR088C
uniprot id: P20424
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm
messages: Fungal signal recognition particle (SRP) complex consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14. SRP54 interacts with SRP101.
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA and also binds the signal sequence.
messages: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPAse-activating proteins (GAPs), thereby resolving their association.

559292:YBR177C
gene id: 559292:YBR177C
uniprot id: P38295
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
messages: Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.
messages: Present with 2550 molecules/cell in log phase SD medium.

559292:YDR505C
gene id: 559292:YDR505C
uniprot id: P50896
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSP1 family.
messages: Cytoplasm
messages: DNA polymerase alpha mutation suppressor.
messages: Mitochondrion
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YPR178W
gene id: 559292:YPR178W
uniprot id: P20053
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Involved in RNA splicing. Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly.
messages: Nucleus
messages: Present with 1770 molecules/cell in log phase SD medium.

559292:YHR174W
gene id: 559292:YHR174W
uniprot id: P00925
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.
messages: Present with 2610 molecules/cell in log phase SD medium.

559292:YOL093W
gene id: 559292:YOL093W
uniprot id: Q12400
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Present with 4090 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs.

559292:YJL193W
gene id: 559292:YJL193W
uniprot id: P39542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family.
messages: Membrane

559292:YIL075C
gene id: 559292:YIL075C
uniprot id: P32565
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S1 family.
messages: Interacts with UBR1.
messages: N-acetylated by NAT1.
messages: Present with 4750 molecules/cell in log phase SD medium.

559292:YLR361C
gene id: 559292:YLR361C
uniprot id: Q05924
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 1940 molecules/cell in log phase SD medium.
messages: Required for cell cycle progression. Has a role in the completion of START.

559292:YLR447C
gene id: 559292:YLR447C
uniprot id: P32366
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Present with 1630 molecules/cell in log phase SD medium.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8509410). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:8509410). This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector (PubMed:8509410). Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores (PubMed:8509410).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

559292:YLL057C
gene id: 559292:YLL057C
uniprot id: Q12358
names: Cofactor
names: Function
names: Similarity
messages: Acts as an alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate.
messages: Belongs to the TfdA dioxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

559292:YKR087C
gene id: 559292:YKR087C
uniprot id: P36163
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.
messages: Forms a redox-dependent disulfide bond, which plays a structural role and regulates its conformational stability and activity.
messages: Homooligomer.
messages: Mitochondrion inner membrane
messages: Protease activity is induced in response to various mitochondrial stress, such as changes in membrane potential, oxidative stress or chronic hyperpolarization, and depends on its C-terminal region.
messages: Protease that is part of the quality control system in the inner membrane of mitochondria (PubMed:12963738, PubMed:22219186, PubMed:24648523, PubMed:27325672). Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OXA1 and COX1 (PubMed:12963738, PubMed:22219186, PubMed:24648523). Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins (PubMed:12963738, PubMed:27325672). Cleaves the misfolded multi-pass membrane protein OXA1 (PubMed:12963738). Involved in quality control of cytochrome oxidase assembly: mediates the cleavage of COX1 in cells lacking COA2 (PubMed:22219186). Required for the stability of the respiratory supercomplexes (PubMed:26365306). Required for TOR signaling (PubMed:27325672).
messages: Reduced ability to form viable colonies on glucose medium after acute treatment with hydrogen peroxide or chronic exposure to carbonyl cyanide m-chlorophenylhydrazone (CCCP) (PubMed:24648523). Cells are resistant to rapamycin and display reduced TOR signaling (PubMed:27325672). Oxidative-stress response is impaired (PubMed:27325672).

559292:YDR359C
gene id: 559292:YDR359C
uniprot id: Q06337
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF1 family.
messages: Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Interacts with SWC4.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus

559292:YKR011C
gene id: 559292:YKR011C
uniprot id: Q02209
names: Miscellaneous
messages: Present with 3150 molecules/cell in log phase SD medium.

559292:YKL006W
gene id: 559292:YKL006W
uniprot id: P36105
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL14 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 45300 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL14 in yeast.

559292:YGL127C
gene id: 559292:YGL127C
uniprot id: P38633
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins.
messages: Nucleus
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YIL132C
gene id: 559292:YIL132C
uniprot id: P40465
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM2 family.
messages: Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2.
messages: Cytoplasm
messages: Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs).
messages: Nucleus
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YCR081W
gene id: 559292:YCR081W
uniprot id: P25648
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 12 family.
messages: Component of the SRB8-11 complex which consists of SRB8, SSN2/SRB9, SSN3/SRB10 and SSN8/SRB11. The SRB8-11 complex associates with the Mediator complex. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair also associate with the RNA polymerase II holoenzyme.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5.
messages: Nucleus
messages: Present with 1730 molecules/cell in log phase SD medium.

559292:YGR204W
gene id: 559292:YGR204W
uniprot id: P07245
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic isozyme of C-1-tetrahydrofolate synthase. The trifunctional enzyme catalyzes the interconversion of the one-carbon derivatives of tetrahydrofolate (THF) between different oxidation states by the enzymatic activities 10-formyltetrahydrofolate synthetase, 5,lO-methenyltetrahydrofolate cyclohydrolase, and 5,lO-methylenetetrahydrofolate dehydrogenase. Involved in the generation of one-carbon intermediates in the biosynthesis of the purine bases.
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Nucleus
messages: Present with 35600 molecules/cell in log phase SD medium.
messages: This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity.

559292:YPL270W
gene id: 559292:YPL270W
uniprot id: P33311
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.
messages: Mitochondrion inner membrane
messages: Present with 3390 molecules/cell in log phase SD medium.

559292:YOL095C
gene id: 559292:YOL095C
uniprot id: Q12039
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. UvrD subfamily.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial genome maintenance and mitochondrial DNA inheritance.

559292:YDL141W
gene id: 559292:YDL141W
uniprot id: P48445
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the biotin--protein ligase family.
messages: Cytoplasm
messages: Monomer.
messages: Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.
messages: Present with 1970 molecules/cell in log phase SD medium.

559292:YDL097C
gene id: 559292:YDL097C
uniprot id: Q12377
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S9 family.
messages: Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
messages: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly.
messages: N-acetylated by NAT1.
messages: Present with 16800 molecules/cell in log phase SD medium.

559292:YJR082C
gene id: 559292:YJR082C
uniprot id: P47128
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.
messages: Nucleus
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YPR010C
gene id: 559292:YPR010C
uniprot id: P22138
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
messages: Present with 14100 molecules/cell in log phase SD medium.
messages: Three distinct zinc-containing RNA polymerases are found in eukaryotic nuclei: polymerase I for the ribosomal RNA precursor, polymerase II for the mRNA precursor, and polymerase III for 5S and tRNA genes.
messages: nucleolus

559292:YNL291C
gene id: 559292:YNL291C
uniprot id: P41821
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-permeable, cation-selective stretch-activated channel (SAC). Required for calcium influx and for vitality of MATa cells in a late, pheromone-induced event of the mating process requiring calcium induced signaling. Functions together with CCH1 to ensure that adequate levels of Ca(2+) are supplied to PMR1 to sustain secretion and growth. Required for growth in low-calcium environments. Together with CCH1, essential for tolerance to iron stress, which leads to an increased oxidative poise, and to cold stress.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Interacts with CCH1 to form a Ca(2+) influx channel. Forms an oligomer with a molecular mass of 200 kDa by disulfide bonds.
messages: Membrane
messages: N-glycosylated.
messages: Present with 3210 molecules/cell in log phase SD medium.
messages: Truncation mutant consisting of amino acids 1-360 is fully functional. Truncation mutants consisting of amino acids 1-400 and 1-22 are partially functional. Truncation mutants consisting of amino acids 1-455, 1-133, and a mutant in which amino acids 3-22 are deleted, are not functional in Ca(2+) uptake.

559292:YDR219C
gene id: 559292:YDR219C
uniprot id: Q04922
names: Miscellaneous
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YAR028W
gene id: 559292:YAR028W
uniprot id: P39548
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.
messages: Membrane
messages: Present with 1835 molecules/cell in log phase SD medium.

559292:YOR302W
gene id: 559292:YOR302W
uniprot id: P08521
names: Function
names: Similarity
messages: Arginine attenuator peptide (AAP) that has a regulatory role in the production of arginine-specific carbamoyl phosphate synthetase. Encoded by an upstream open reading frame (uORF) within the 5'-leader region of arginine-specific carbamoyl phosphate synthetase small chain (CPA1) mRNA, it attenuates the translation of the downstream CPA1 ORF. In the presence of high concentrations of arginine, ribosomes translating the uORF encoding AAP stall at the termination codon, resulting in reduced translation from the downstream CPA1 initiation codon.
messages: Belongs to the arginine attenuator peptide family.

559292:YHR158C
gene id: 559292:YHR158C
uniprot id: P38853
names: Function
names: Miscellaneous
names: Subunit
messages: Has a role in cell morphogenesis and cell fusion and may antagonize the PKC1 pathway.
messages: Interacts with KEL2.
messages: Present with 1350 molecules/cell in log phase SD medium.

559292:YDR427W
gene id: 559292:YDR427W
uniprot id: Q04062
names: Function
names: Miscellaneous
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S11 family.
messages: Present with 12400 molecules/cell in log phase SD medium.

559292:YDR443C
gene id: 559292:YDR443C
uniprot id: P38931
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the SRB8-11 complex which consists of SRB8, SSN2/SRB9, SSN3/SRB10 and SSN8/SRB11. The SRB8-11 complex associates with the Mediator complex. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair also associate with the RNA polymerase II holoenzyme.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5.
messages: Nucleus
messages: Phosphorylated. PKA-dependent phosphorylation at 'Ser-608' is enhanced by activation of the RAS signaling pathway.

559292:YMR231W
gene id: 559292:YMR231W
uniprot id: P12868
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS11 family.
messages: Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex, which is composed of a core of the 4 class C Vps proteins PEP5/VPS11, PEP3/VPS18, VPS16, VPS33 associated to VAM6/VPS39 and VPS41/VAM2. HOPS associates with phosphoinositides and the PX domain of VAM7. Component of the class C core vacuole/endosome tethering (CORVET) complex, which is composed of a core of the 4 class C Vps proteins PEP5/VPS11, PEP3/VPS18, VPS16, VPS33 associated to VPS3/PEP6 and VPS8. Interacts with PEP3, PEP7 and VAM7. Interacts with the E2 ubiquitin-conjugating enzyme UBC4 and histones H3 and H4.
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. It is required for gluconeogenic growth of yeast. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (PubMed:3062374, PubMed:10978279, PubMed:10944212, PubMed:16601699). Acts as component of the CORVET complex that is required for transport between endosome and vacuole. CORVET is an effector for the endosomal Rab GTPase VPS21 (PubMed:17488625). Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation (PubMed:22570702).
messages: Vacuole membrane

559292:YKR084C
gene id: 559292:YKR084C
uniprot id: P32769
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.
messages: Cytoplasm
messages: Interacts with DOM34.
messages: Involved in protein translation. Together with DOM34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Present with 2750 molecules/cell in log phase SD medium.

559292:YOR149C
gene id: 559292:YOR149C
uniprot id: Q04174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi. Involved in plasmid maintenance with SMP2.
messages: Belongs to the glycosyltransferase 22 family. PIGZ subfamily.
messages: Endoplasmic reticulum membrane

559292:YER163C
gene id: 559292:YER163C
uniprot id: P32656
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase DUG1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1300 molecules/cell in log phase SD medium.

559292:YKL212W
gene id: 559292:YKL212W
uniprot id: P32368
names: Caution
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: It is uncertain whether Met-1 or Met-59 is the initiator.
messages: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:10625610, PubMed:11792713). Has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10625610). May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton (PubMed:11514624).
messages: Present with 48000 molecules/cell in log phase SD medium.

559292:YLR323C
gene id: 559292:YLR323C
uniprot id: P53769
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
messages: Belongs to the CWC24 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus
messages: Present with 996 molecules/cell in log phase SD medium.

559292:YDR307W
gene id: 559292:YDR307W
uniprot id: Q06644
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Probable protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

559292:YDL111C
gene id: 559292:YDL111C
uniprot id: Q12277
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family.
messages: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits DIS3 and RRP6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components CSL4, RRP4 and RRP40 located on the top of the ring structure.
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP42 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.
messages: Present with 7110 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR368W
gene id: 559292:YLR368W
uniprot id: Q05930
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with SKP1. Component of the probable SCF(MDM30) complex containing CDC53, SKP1, RBX1 and MDM30. Interacts with SKP1 and FZO1.
messages: Mitochondrion
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Recognizes FZO1 and regulates the amount of FZO1. Regulatory factor for the mitochondrial fusion machinery. Required for mitochondrial DNA maintenance.

559292:YDR464W
gene id: 559292:YDR464W
uniprot id: P38904
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PRP8 and RAP1.
messages: Negative regulator of PRP3 and PRP4 genes.
messages: Nucleus

559292:YAL030W
gene id: 559292:YAL030W
uniprot id: P31109
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endomembrane system
messages: Palmitoylated by SWF1.
messages: SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion.

559292:YGR097W
gene id: 559292:YGR097W
uniprot id: P48361
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RGC1 family.
messages: Component of the RNA polymerase II holoenzyme. Interacts with RPO21 and SSN8.
messages: Cytoplasm
messages: Phosphorylated in response to various stresses. stress-induced phosphorylation is partially dependent on HOG1.
messages: Positive regulator of FPS1 glycerol channel required for the glycerol efflux. As a component of the RNA polymerase II holoenzyme, is required for SSN8 destruction in response to oxidative stress but not heat shock. Required for cell survival in response to heat shock independent of SSN8.

559292:YMR253C
gene id: 559292:YMR253C
uniprot id: Q04835
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: To yeast YPL264c.

559292:YDR529C
gene id: 559292:YDR529C
uniprot id: P00128
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane
messages: Present with 10100 molecules/cell in log phase SD medium.
messages: Was originally thought to be the ubiquinone-binding protein (QP-C).

559292:YIL072W
gene id: 559292:YIL072W
uniprot id: P20050
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: Meiosis-specific.
messages: Nucleus
messages: Probable constituent of the synaptonemal complex during meiosis. May interact with RED1.

559292:YDL124W
gene id: 559292:YDL124W
uniprot id: Q07551
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Present with 4030 molecules/cell in log phase SD medium.
messages: Reduces aromatic alpha-keto amides, aliphatic and aromatic alpha-keto esters, but not beta-keto esters.
messages: The N-terminus is blocked.
messages: Transiently induced shortly after the switch from aerobic to anaerobic growth (at protein level).

559292:YGR294W
gene id: 559292:YGR294W
uniprot id: P53343
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
messages: Membrane

559292:YGR184C
gene id: 559292:YGR184C
uniprot id: P19812
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UBR1 family.
messages: Interacts with UBC2. Interacts with RPN2, RPT1 and RPT6 from the 26S proteasome.
messages: The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

559292:YER087W
gene id: 559292:YER087W
uniprot id: P39965
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion
messages: Present with 477 molecules/cell in log phase SD medium.

559292:YLR025W
gene id: 559292:YLR025W
uniprot id: P39929
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts a component of the ESCRT-III complex required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB) (PubMed:11559748, PubMed:12194857). The sequential action of ESCRT-0, -I, and -II together with the ordered assembly of ESCRT-III links membrane invagination to cargo sorting (PubMed:12194857). Membrane scission in the neck of the growing vesicle releases mature, cargo-laden ILVs into the lumen (PubMed:24139821, PubMed:24711499). ESCRT-III is critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery (PubMed:24139821, PubMed:24711499). SNF7 is the most abundant ESCRT-III subunit which forms membrane-sculpting filaments with 30 Angstrom periodicity and a exposed cationic membrane-binding surface (PubMed:26670543). Its activation requires a prominent conformational rearrangement to expose protein-membrane and protein-protein interfaces (PubMed:26670543). SNF7 filaments then form spirals that could function as spiral springs (PubMed:26522593). The elastic expansion of compressed SNF7 spirals generates an area difference between the two sides of the membrane and thus curvature which could be the origin of membrane deformation leading eventually to fission (PubMed:26522593). SNF7 recruits BRO1, which in turn recruits DOA4, which deubiquitinates cargos before their enclosure within MVB vesicles (PubMed:11029042, PubMed:15935782). ESCRT-III is also recruited to the nuclear envelope (NE) by integral INM proteins to surveil and clear defective nuclear pore complex (NPC) assembly intermediates to ensure the fidelity of NPC assembly (PubMed:25303532).
messages: Belongs to the SNF7 family.
messages: Core component of the ESCRT-III complex (endosomal sorting required for transport complex III) (PubMed:12194857, PubMed:18854142). ESCRT-III appears to be sequentially assembled as a flat lattice on the endosome membrane and forms a transient 450 kDa complex that contains DID4, oligomerized SNF7, VPS20 and VPS24 (PubMed:18854142). SNF7 polymerizes into spirals at the surface of lipid bilayers (PubMed:26522593). SNF7 polymerization is nucleated by association of SNF7 with VPS20; the process is terminated through association of VPS24, possibly by capping the SNF7 filament (PubMed:24058170, PubMed:24711499). Interacts with VTA1; the interaction requires DID2 (PubMed:16601096, PubMed:24058170). Interacts with BRO1 (PubMed:15086794, PubMed:15935782, PubMed:24058170). Interacts with DOA4 (PubMed:26427873). Interacts with HEH1 and HEH2 (PubMed:25303532). Interacts with RIM20 and YGR122W (PubMed:24058170).
messages: Cytoplasm
messages: Endosome membrane
messages: Exhibits defects in the sorting and processing of native vacuolar proteins (PubMed:3062374).
messages: Nucleus envelope
messages: Present with 3270 molecules/cell in log phase SD medium.
messages: The N-terminus (residues 1 to 11) forms an amphipathic helix which is required for the association to membrane.
messages: Was originally thought to be a nuclear protein and mutations were shown to prevent full derepression of the SUC2 (invertase) gene.

559292:YBL057C
gene id: 559292:YBL057C
uniprot id: P34222
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: Present with 2190 molecules/cell in log phase SD medium.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

559292:YGR119C
gene id: 559292:YGR119C
uniprot id: P48837
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin GLFG family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP57 is part of the NUP57 subcomplex (NIC96, NSP1, NUP49, NUP57) interacting with NUP49 and NSP1. Interacts through its FG repeats with karyopherins.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP57 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.
messages: Nucleus membrane
messages: Present with 9310 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YGL005C
gene id: 559292:YGL005C
uniprot id: P53195
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
messages: Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.
messages: Golgi apparatus membrane
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YJR007W
gene id: 559292:YJR007W
uniprot id: P20459
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Eukaryotic translation initiation factor 2 (eIF-2) is a heterotrimer composed of an alpha, a beta and a gamma subunit. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.
messages: Phosphorylated; phosphorylation on Ser-52 by the GCN2 protein kinase occurs in response to low amino acid, carbon, or purine availability.
messages: Present with 17100 molecules/cell in log phase SD medium.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

559292:YKL192C
gene id: 559292:YKL192C
uniprot id: P32463
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).
messages: Complex I is composed of about 30 different subunits.
messages: Mitochondrion
messages: Present with 60500 molecules/cell in log phase SD medium.

559292:YOL152W
gene id: 559292:YOL152W
uniprot id: Q12333
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: By transcription factor MAC1 upon copper deprivation.
messages: Cell membrane
messages: Cell surface metalloreductase. May be involved in copper homeostasis.

559292:YIL071C
gene id: 559292:YIL071C
uniprot id: P40512
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of a COP9 signalosome-like (CSN) complex, composed of RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. Interacts with PRT1 and RPG1, 2 subunits of the core complex of translation initiation factor 3 (eIF3).
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response. PCI8 may also be involved in transcriptional and translational control.
messages: Cytoplasm
messages: Nucleus
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YDL079C
gene id: 559292:YDL079C
uniprot id: P50873
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

559292:YLR086W
gene id: 559292:YLR086W
uniprot id: Q12267
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
messages: Chromosome
messages: Cytoplasm
messages: Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.
messages: Nucleus
messages: Present with 573 molecules/cell in log phase SD medium.
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer.

559292:YIL161W
gene id: 559292:YIL161W
uniprot id: P40449
names: Miscellaneous
messages: Present with 1230 molecules/cell in log phase SD medium.

559292:YNR022C
gene id: 559292:YNR022C
uniprot id: P53724
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

559292:YPL016W
gene id: 559292:YPL016W
uniprot id: P09547
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWI1 family.
messages: Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.
messages: Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
messages: Nucleus
messages: Present with 92 molecules/cell in log phase SD medium.
messages: The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form (By similarity). The first 37 residues of this domain are sufficient for aggregation, propagation, and transmission of the [SWI+] prion.
messages: [SWI+] is the prion form of SWI1 (PubMed:18362884). [SWI+] is the result of a conformational change of the cellular SWI1 protein that becomes self-propagating and infectious. This conformational change generates a form of SWI1 that assembles into amyloid fibrils (PubMed:20679490). [SWI+]-aggregates sequester soluble SWI1, resulting in reduced growth on carbon sources other than glucose, reminiscent of a partial loss of function of the SWI/SNF chromatin-remodeling complex. [SWI+] can be cured by GdnHCl and by deletion of the molecular chaperone HSP104, which is required for [SWI+] propagation (PubMed:18362884). [SWI+] propagation is highly dependent upon the action of members of the Hsp70 molecular chaperone system, specifically the Hsp70 SSA, two of its J-protein co-chaperones, SIS1 and YDJ1, and the nucleotide exchange factors of the Hsp110 family (SSE1/2). Both under- and overexpression of components of this system initiate rapid loss of the prion from the cell population. It is speculated that prion properties of transcription factors may generate an optimized phenotypic heterogeneity that buffers yeast populations against diverse environmental insults (PubMed:21379326).

559292:YPL198W
gene id: 559292:YPL198W
uniprot id: Q12213
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 7080 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL30 in yeast.

559292:YFR031C-A
gene id: 559292:YFR031C-A
uniprot id: P0CX45
uniprot id: P0CX46
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 4050 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL2 in yeast.

559292:YML124C
gene id: 559292:YML124C
uniprot id: P09734
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with NUM1.
messages: Present with 12300 molecules/cell in log phase SD medium.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

559292:YDL205C
gene id: 559292:YDL205C
uniprot id: P28789
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Catalyzes the tetrapolymerization of the monopyrrole porphobilinogen (PBG) into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: Present with 8480 molecules/cell in log phase SD medium.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

559292:YNL191W
gene id: 559292:YNL191W
uniprot id: P53871
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DUG3 family.
messages: Component of the GSH degradosomal complex composed of at least DUG1, DUG2 and DUG3.
messages: Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond.
messages: Cytoplasm
messages: Present with 7300 molecules/cell in log phase SD medium.

559292:YLR092W
gene id: 559292:YLR092W
uniprot id: Q12325
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: High affinity uptake of sulfate into the cell.
messages: Membrane

559292:YLR190W
gene id: 559292:YLR190W
uniprot id: Q06324
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Bud tip
messages: Interacts with MYO2 and PCL7.
messages: Involved in the guiding of mitochondrial tubules to the bud tip during cell division.
messages: Mitochondrion outer membrane
messages: Phosphorylated by the cyclin-CDK PCL7-PHO85.
messages: Present with 1070 molecules/cell in log phase SD medium.

559292:YHR058C
gene id: 559292:YHR058C
uniprot id: P38782
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. MED6 interacts directly with SRB4/MED17 and SRB7/MED21.
messages: Nucleus
messages: Present with 4824 molecules/cell in log phase SD medium.

559292:YKR104W
gene id: 559292:YKR104W
uniprot id: P0CE69
names: Caution
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Could be the product of a pseudogene. This is the C-terminal part of the ABC transporter NFT1. S288c has a stop codon in position 1219, which disrupts the gene coding for this protein and produces two ORFs YKR103W and YKR104W. A contiguous sequence for ABC transporter NFT1 can be found in strains Sigma 1278B, EG123 and SK1 (AC P0CE70).

559292:YDR352W
gene id: 559292:YDR352W
uniprot id: Q06328
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the laat-1 family.
messages: May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole.
messages: Present with 6350 molecules/cell in log phase SD medium.
messages: Resistant to canavanine.
messages: Vacuole membrane

559292:YGL187C
gene id: 559292:YGL187C
uniprot id: P04037
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5B family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:7851399, PubMed:30598556, PubMed:30598554). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: Present with 9410 molecules/cell in log phase SD medium.

559292:YKR007W
gene id: 559292:YKR007W
uniprot id: Q02205
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal activation of TORC1 signaling during high hydrostatic pressure (mechanical stress) (PubMed:32801125). Abnormal punctate localization of TOR1 (PubMed:32801125). Increases cellular levels of glutamine and alanine during high hydrostatic pressure (mechanical stress) (PubMed:32801125). Sensitive to rapamycin and high hydrostatic pressure (mechanical stress) (PubMed:29698392, PubMed:32801125). Simultaneous disruption of PIB2 results in loss of viability (PubMed:29698392).
messages: Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Component of the EGO complex, at least composed of GTR2, SLM4 and MEH1.
messages: Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272). Component of the EGO complex, a complex involved in the regulation of microautophagy (PubMed:15989961).
messages: Present with 2740 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YGR208W
gene id: 559292:YGR208W
uniprot id: P42941
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Present with 13800 molecules/cell in log phase SD medium.

559292:YKR021W
gene id: 559292:YKR021W
uniprot id: P36117
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALY1 family.
messages: Cytoplasm
messages: Interacts with RSP5.
messages: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
messages: Present with 414 molecules/cell in log phase SD medium.
messages: Ubiquitinated by RSP5.

559292:YLR425W
gene id: 559292:YLR425W
uniprot id: Q06412
names: Domain
names: Function
names: Subunit
messages: Guanine nucleotide-exchange factor (GEF) for RHO1 that stimulates the exchange of RHO1 GDP-bound form into GTP-bound form. Required for signaling of cell wall defects to RHO1.
messages: Interacts with RHO1.
messages: The DH domain mediates interaction with RHO1.

559292:YHR128W
gene id: 559292:YHR128W
uniprot id: P18562
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate in the pyrimidine salvage pathway.
messages: Induced by uracil.

559292:YMR184W
gene id: 559292:YMR184W
uniprot id: Q03233
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In response to the DNA-damaging agent MMS.
messages: Involved in ER-associated protein degradation (ERAD).
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YHR213W-A
gene id: 559292:YHR213W-A
uniprot id: Q8TGT4
names: Subcellular Location Annotation
messages: Membrane

559292:YGL150C
gene id: 559292:YGL150C
uniprot id: P53115
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (PubMed:10952318, PubMed:12887900). Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates (PubMed:10952318, PubMed:10361278). The INO80 complex is involved in DNA repair by associating with 'Ser-129' phosphorylated H2A histones as a response to DNA damage (PubMed:15607974, PubMed:15607975).
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.
messages: Nucleus
messages: Present with 1110 molecules/cell in log phase SD medium.
messages: The DBINO region is involved in binding to DNA.

559292:YER112W
gene id: 559292:YER112W
uniprot id: P40070
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple spliceosome snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM4 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. LSM4, probably in a complex that contains LSM2-LSM7 but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA. LSM4 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a doughnut shape. The LSm subunits are arranged in the order LSM1, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. Except for LSM1, where a C-terminal helix crosses the ring structure to form additional interactions with LSM3 and LSM6, each subunit interacts only with its two neighboring subunits. The LSM1-LSM7 complex interacts with PAT1; within the complex PAT1 has direct interactions with LSM2 and LSM3. Component of the heptameric LSM2-LSM8 complex that forms a seven-membered ring structure with a doughnut shape; an RNA strand can pass through the hole in the center of the ring structure. The LSm subunits are arranged in the order LSM8, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. LSM2-LSM8 associates with PAT1 and XRN1. A complex comprising LSM2-LSM7 without LSM1 or LSM8 may exist. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 3440 molecules/cell in log phase SD medium.

559292:YMR133W
gene id: 559292:YMR133W
uniprot id: P32841
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the REC114 family.
messages: Chromosome
messages: Interacts with MEI4, MER2 and REC104. Component of the MER2-MEI4-REC114 complex.
messages: Meiosis-specific.
messages: Nucleus
messages: Required for the production of double-strand breaks (DSBs) in meiotic recombination initiation; not required for mitosis. Plays a role in activation of the DSB nuclease SPO11 at recombination hotspots. Prevents accumulation of meiotic double strand break intermediates and is needed for the proper timing of the first meiotic division. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.

559292:YDR517W
gene id: 559292:YDR517W
uniprot id: Q04410
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Interacts with BUG1 (via C-terminus), probably forming a heterooligomer consisting of a GRH1 dimer and a BUG1 dimer. Interacts with COPII coat components SEC23, SEC24, SFB2 and SFB3.
messages: Involved in the spindle assembly checkpoint. Involved in ER to Golgi vesicle-mediated transport by either facilitating USO1-dependent and -independent tethering or increasing target accuracy of fusion events of COPII-coated vesicles.
messages: N-terminal acetylation; by N-terminal acetyltransferase NatC.
messages: Present with 2730 molecules/cell in log phase SD medium.
messages: cis-Golgi network membrane

559292:YPR190C
gene id: 559292:YPR190C
uniprot id: P32349
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus
messages: Present with 2520 molecules/cell in log phase SD medium.

559292:YBR276C
gene id: 559292:YBR276C
uniprot id: P38148
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle.

559292:YGL249W
gene id: 559292:YGL249W
uniprot id: P53061
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZIP2 family.
messages: Chromosome
messages: During meiosis.
messages: Interacts with ZIP3.
messages: Nucleus
messages: Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis. Required for the normal localization of MSH4 to chromosomes.

559292:YPL250C
gene id: 559292:YPL250C
uniprot id: Q12048
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Expression is dramatically increased under nitrogen starvation conditions and is regulated by the transcription factor GCN4 (PubMed:26565778).
messages: Interacts with ATG9 (PubMed:26565778).
messages: Involved in both selective and non-selective autophagy (PubMed:26565778). Does not appear to play a role in determining the size of autophagosomes, but rather influences their formation rate (PubMed:26565778). With ATG9, plays a role in the delivery of donor membrane to expanding phagophore (PubMed:26565778).
messages: Preautophagosomal structure membrane
messages: Present with 450 molecules/cell in log phase SD medium.
messages: Reduces the autophagy flux induced by nitrogen starvation as well as the flux of the cytoplasm-to-vacuole targeting (cvt) pathway (PubMed:26565778).
messages: The C-terminal 10 residues are required for the association with ATG9 (PubMed:26565778).

559292:YDR079C-A
gene id: 559292:YDR079C-A
uniprot id: Q3E7C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription (PubMed:15220919). Interacts with TFB2 (PubMed:19172752).
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits.
messages: Nucleus

559292:YLL007C
gene id: 559292:YLL007C
uniprot id: Q07799
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a transiant heterodimeric complex with DCK1, that acts as a guanine nucleotide exchange factor (GEF) for the small GTPase RHO5 (PubMed:25598154). DCK1, LMO1 and RHO5 relocate to mitochondria upon oxidative stress and trigger cell death (PubMed:25598154). The DCK1/LMO1/RHO5 signaling module mediates mitochondrial turnover under nitrogen starvation conditions via mitophagy (PubMed:25598154). The DCK1/LMO1/RHO5 signaling module also plays a role in cell wall integrity signaling (PubMed:25598154).
messages: Forms an active heterodimer with DCK1.
messages: Leads to hyper-resistance to cell wall stress agents such as calcofluor white and Congo red.
messages: Mitochondrion
messages: Present with 486 molecules/cell in log phase SD medium.

559292:YIL078W
gene id: 559292:YIL078W
uniprot id: P04801
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Present with 42600 molecules/cell in log phase SD medium.

559292:YGL155W
gene id: 559292:YGL155W
uniprot id: P18898
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl diphosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity (PubMed:2034682, PubMed:1400380). The beta subunit is responsible for isoprenoid and peptide-binding (PubMed:9109664, PubMed:10491163).
messages: Cytoplasm
messages: Heterodimer of an alpha (RAM2) and a beta (CDC43) subunit.
messages: Present with 3940 molecules/cell in log phase SD medium.

559292:YER093C
gene id: 559292:YER093C
uniprot id: P40061
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RICTOR family.
messages: Cell membrane
messages: Essential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AVO2 and SLM1.
messages: Phosphorylated by TOR2; when part of TORC2.
messages: Present with 1840 molecules/cell in log phase SD medium.
messages: The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin. TSC11 binds to the N-terminal HEAT repeat region in TOR2 and is required for TORC2 integrity by tethering AVO1 and AVO2 to the complex.
messages: Vacuole membrane

559292:YPR119W
gene id: 559292:YPR119W
uniprot id: P24869
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
messages: Interacts with NAP1.
messages: Maximally expressed before mitosis. The levels peak late in the G2 phase of the cell cycle and are at a minimum in G1 phase.
messages: Present with 339 molecules/cell in log phase SD medium.

559292:YJL130C
gene id: 559292:YJL130C
uniprot id: P07259
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GATase (glutamine amidotransferase) and CPSase (carbamoyl phosphate synthase) form together the glutamine-dependent CPSase (GD-CPSase) (EC 6.3.5.5).
messages: In eukaryotes EC 6.3.5.5 is synthesized by two pathway-specific (arginine and pyrimidine) genes under separate control.
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
messages: Present with 11000 molecules/cell in log phase SD medium.
messages: The DHOase domain is defective.
messages: This protein is a 'fusion' protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase).

559292:YGL017W
gene id: 559292:YGL017W
uniprot id: P16639
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family.
messages: Cytoplasm
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed:2185248). Does not arginylate cysteine residues (By similarity).
messages: Present with 2030 molecules/cell in log phase SD medium.

559292:YDL232W
gene id: 559292:YDL232W
uniprot id: Q99380
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST4 family.
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:8175708, PubMed:10677492, PubMed:16297388, PubMed:16096345, PubMed:15831493, PubMed:15886282, PubMed:9405463, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962). Interacts with SEC61, SBH1 and SSS1 (PubMed:15831493).
messages: Endoplasmic reticulum membrane
messages: Present with 2430 molecules/cell in log phase SD medium.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

559292:YCR041W
gene id: 559292:YCR041W
uniprot id: P37265
names: Function
names: Subcellular Location Annotation
messages: May play a role in proper chromosome segregation. Suppresses the high-frequency loss of mini-chromosomes when overexpressed, and this suppression is completely dependent on silencing protein SIR4.
messages: Membrane

559292:YHR111W
gene id: 559292:YHR111W
uniprot id: P38820
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
messages: Present with 2620 molecules/cell in log phase SD medium.

559292:YKL214C
gene id: 559292:YKL214C
uniprot id: P36036
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with mRNPs. Interacts with YRA1.
messages: Belongs to the YRA1 family.
messages: Involved in export of poly(A) mRNAs from the nucleus. Recruited to the coding sequences as well as poly-A sites of active genes.
messages: Nucleus
messages: Present with 1310 molecules/cell in log phase SD medium.

559292:YLR360W
gene id: 559292:YLR360W
uniprot id: Q05919
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal reticulophagy.
messages: Component of the VPS34 PI3-kinase complex II composed of VPS15, VPS30, VPS34 and VPS38.
messages: Endosome membrane
messages: Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane.
messages: Present with 1070 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YER138C
gene id: 559292:YER138C
uniprot id: Q03612
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YER137C-A ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YGL252C
gene id: 559292:YGL252C
uniprot id: P32608
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the GppA/Ppx family.
messages: Present with 3260 molecules/cell in log phase SD medium.
messages: Required for a novel path of interorganelle communication between mitochondria, peroxisomes and the nucleus, thereby maintaining a functional metabolic interaction between the tricarboxylic acid and glyoxylate cycles. In particular, required for the retrograde expression of the peroxisomal isoform of citrate synthase, CIT2.

559292:YPL269W
gene id: 559292:YPL269W
uniprot id: P32526
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Involved in karyogamy. Component of a cortical adaptor complex that orients cytoplasmic microtubules. It may be involved in anchoring cytoplasmic microtubules to the cell cortex.
messages: Nucleus
messages: Present with 656 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YOL031C
gene id: 559292:YOL031C
uniprot id: Q08199
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIL1 family.
messages: By the unfolded protein response (UPR).
messages: Endoplasmic reticulum lumen
messages: Interacts with KAR2.
messages: N-glycosylated.
messages: Present with 2420 molecules/cell in log phase SD medium.
messages: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2.

559292:YHR081W
gene id: 559292:YHR081W
uniprot id: P38801
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with nuclear form of the RNA exosome complex. Interacts with RRP4, RRP6, RRP45 and RRP46.
messages: Belongs to the C1D family.
messages: Nucleus
messages: Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites. Required for activity of RRP6 in 7S pre-rRNA processing. Also has a role in 3'-processing of U4 and U5 small nuclear RNAs (snRNAs). Acts as a mRNA export factor. Mediates mRNA degradation upon UV irradiation. Maintains genome integrity where it is involved in both non-homologous end joining (NHEJ) and homologous recombination pathway repair of double strand DNA breaks. During NHEJ, required for joining 3'-overhanging ends. Also involved in telomere length regulation and maintenance.

559292:YGL213C
gene id: 559292:YGL213C
uniprot id: Q02793
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the SKI complex composed of at least SKI2, SKI3 and SKI8. The SKI complex interacts with SKI7, which makes the link between the SKI complex and the exosome in order to perform mRNA degradation.
messages: Cytoplasm
messages: Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also a component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology.
messages: Nucleus
messages: Present with 1710 molecules/cell in log phase SD medium.

559292:YJR041C
gene id: 559292:YJR041C
uniprot id: P47108
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of very early pre-60S ribosomal particles containing 27SA2 pre-rRNA. Interacts with URB1. Together with DBP6, NOP8, URB1 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.
messages: Present with 1660 molecules/cell in log phase SD medium.
messages: Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly.
messages: nucleolus

559292:YHR214C-D
gene id: 559292:YHR214C-D
uniprot id: P0CX92
uniprot id: P0CX93
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: Product of a dubious gene prediction unlikely to encode a functional protein. Because of that it is not part of the S.cerevisiae S288c complete/reference proteome set.

559292:YDL248W
gene id: 559292:YDL248W
uniprot id: Q07788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUP/COS family.
messages: Membrane

559292:YOR384W
gene id: 559292:YOR384W
uniprot id: Q08908
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: By iron deprivation.
messages: Cell membrane
messages: Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity).

559292:YNL183C
gene id: 559292:YNL183C
uniprot id: P22211
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Dephosphorylation by SIT4 activates NPR1 kinase activity.
messages: Hyperphosphorylated in nitrogen-rich growth medium. Nitrogen limitation (or rapamycin treatment) leads to substantial, though not complete dephosphorylation. Autophosphorylation plays only a minor role and seems not to be regulated by the quality of the nitrogen source.
messages: Interacts with TIP41.
messages: Nutrient-regulated protein kinase that promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression. Under poor nitrogen growth conditions, required for post-Golgi sorting of the general amino acid permease GAP1 and the three known ammonia permeases, MEP1/2/3, to the plasma membrane. Contributes also to the stability and the retention of GAP1 at the plasma membrane. Inversely, promotes the degradation of tryptophan permease TAT2 under the same conditions. Activity is regulated by the TOR signaling pathway via phosphatase SIT4. Although thought to be involved in regulation of GLN3-dependent transcription by nitrogen catabolite repression, this seems to be an indirect effect from the reduced uptake of the nitrogen-repressing compound.
messages: Present with 284 molecules/cell in log phase SD medium.

559292:YOR216C
gene id: 559292:YOR216C
uniprot id: Q12234
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Golgi apparatus lumen
messages: Involved in the structural organization of the cis-Golgi and in vesicle targeting/fusion stages of ER to Golgi transport.
messages: Present with 7620 molecules/cell in log phase SD medium.
messages: The GRIP domain binds to ARF1, which leads to the Golgi localization of RUD3.

559292:YPL257W-A
gene id: 559292:YPL257W-A
uniprot id: P0CX70
uniprot id: P0CX71
uniprot id: P0CX72
uniprot id: P0CX73
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR6 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ER1 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-PL is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YLR107W
gene id: 559292:YLR107W
uniprot id: Q12090
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
messages: Belongs to the REXO1/REXO3 family.
messages: Cytoplasm
messages: Nucleus

559292:YOR310C
gene id: 559292:YOR310C
uniprot id: Q12499
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP5/NOP56 family.
messages: Interacts with SIK1/NOP56 and NOP1. Interacts with the trimethylguanosine synthase TGS1. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Present with 34700 molecules/cell in log phase SD medium.
messages: Required for pre-18S rRNA processing. May bind microtubules.
messages: nucleolus

559292:YDR153C
gene id: 559292:YDR153C
uniprot id: Q03769
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Endosome membrane
messages: Interacts with the clathrin adapter GGA2 and the clathrin adapter complex AP-1.
messages: Involved in the recruitment of clathrin to the Golgi network and endosomes to form clathrin coated vesicles. Plays a role in the trafficking of clathrin between the Golgi network and endosomes. Binds to membranes enriched in phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) and, in association with VPS27, is involved in protein sorting at the multivesicular body (MVB).
messages: Present with 8100 molecules/cell in log phase SD medium.

559292:YPL237W
gene id: 559292:YPL237W
uniprot id: P09064
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Eukaryotic translation initiation factor 2 (eIF-2) is a heterotrimer composed of an alpha, a beta and a gamma subunit. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. SUI3 interacts with GCD6 and TIF5/eIF-5.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

559292:Q0120
gene id: 559292:Q0120
uniprot id: P03879
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Forms a ternary complex with intron derived RNA and the imported mitochondrial leucyl-tRNA synthetase NAM2. The proteins do not interact directly with each other.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: Mitochondrial mRNA maturase required for splicing of intron 4 of the cytochrome b (COB) gene, containing its own coding sequence, and intron 4 in COX1, coding for the related homing endonuclease aI4. In vivo splicing requires in addition the imported mitochondrial leucyl-tRNA synthetase NAM2. Both proteins seem to stimulate the intrinsic ribozyme activity of intron bI4 through binding to and stabilizing specific secondary and tertiary structure elements in the RNA.
messages: Mitochondrion
messages: Residues 385 to 638 are sufficient for maturase activity.
messages: The mature protein may arise from proteolytic cleavage of an in-frame translation of COB exons 1 to 4 plus intron 4, containing the bI4 open reading frame. Cleavage would take place close to the Met-385 resulting in an active maturase of about 30 kDa.

559292:YHR092C
gene id: 559292:YHR092C
uniprot id: P32467
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.
messages: Low-affinity glucose transporter. Can also transport xylose.
messages: Xylose uptake is strongly inhibited by glucose.

559292:YPR057W
gene id: 559292:YPR057W
uniprot id: Q99177
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRR1 family.
messages: Interacts with HTA1 and associates with the spliceosome.
messages: Involved in mRNA splicing. Required for snRNA accumulation and manufacture of snRNPs.
messages: Nucleus
messages: Present with 1870 molecules/cell in log phase SD medium.

559292:YNL130C
gene id: 559292:YNL130C
uniprot id: P17898
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the final step in the CDP-choline route leading to phosphatidylcholin (PC). Preferentially uses CDP-monomethylethanolamine as aminoalcohol substrate. Shows highest activity toward di- and mono-unsaturated diacylglycerol species as lipid substrates. The CDP-choline pathway only contributes to net PC synthesis if exogenous choline is present. In its absence, this pathway recycles choline from PC turnover and may contribute to maintaining the proper PC species composition.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Mitochondrion outer membrane
messages: Present with 981 molecules/cell in log phase SD medium.
messages: Repressed by inositol.
messages: Requires a divalent cation activator, and is inhibited by CMP. Activated by phospholipids, especially phosphatidylcholine.

559292:YPL219W
gene id: 559292:YPL219W
uniprot id: Q08966
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. PHO80 subfamily.
messages: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL10, negatively controls glycogen accumulation under favorable growth conditions. Involved in phosphorylation and negative regulation of glycogen synthase GSY2. Also has minor GLC8 kinase activity.
messages: Cytoplasm
messages: Forms a cyclin-CDK complex with PHO85.
messages: Nucleus
messages: Present with 396 molecules/cell in log phase SD medium.

559292:YCR053W
gene id: 559292:YCR053W
uniprot id: P16120
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
messages: Present with 26000 molecules/cell in log phase SD medium.

559292:YPL104W
gene id: 559292:YPL104W
uniprot id: P15179
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of aspartate to tRNA(Asp) in the mitochondrion.
messages: Mitochondrion matrix
messages: Present with 1550 molecules/cell in log phase SD medium.

559292:YOR323C
gene id: 559292:YOR323C
uniprot id: P54885
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Present with 6920 molecules/cell in log phase SD medium.

559292:YOR090C
gene id: 559292:YOR090C
uniprot id: Q12511
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex.
messages: Mitochondrion intermembrane space
messages: Present with 7550 molecules/cell in log phase SD medium.
messages: Processed by mitochondrial inner membrane protease (IMP) complex and released to the intermembrane space.

559292:YER124C
gene id: 559292:YER124C
uniprot id: P40077
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DSE1 family.
messages: Bud neck
messages: Expressed in daughter cells.
messages: Expressed periodically during cell division. Requires ACE2, CBK1, MOB2 and SWI5. Expression is also increased under microgravity conditions.
messages: Involved in cell wall metabolism and required for the separation of the mother and daughter cells.
messages: Present with 3080 molecules/cell in log phase SD medium.

559292:YER131W
gene id: 559292:YER131W
uniprot id: P39939
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS26 interacts with eS1 forming part of the mRNA exit tunnel (PubMed:9559554, PubMed:22096102). eS26 interacts with TSR2 (PubMed:10688190, PubMed:12837249).
messages: Cytoplasm
messages: Present with 503000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS26 in yeast.

559292:YOL047C
gene id: 559292:YOL047C
uniprot id: Q08218
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: A combined deletion of the LDS proteins RRT8, LDS1 and LDS2 fails to incorporate dityrosine and another yet uncharacterized component in the outer spore wall.
messages: Belongs to the LDS family.
messages: Involved in spore wall assembly.
messages: Lipid droplet
messages: Present with 155 molecules/cell in log phase SD medium.
messages: Prospore membrane
messages: Spore wall

559292:YMR058W
gene id: 559292:YMR058W
uniprot id: P38993
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multicopper oxidase family.
messages: Binds 4 Cu cations per monomer.
messages: By iron deprivation. Repressed by iron excess.
messages: Cell membrane
messages: Iron transport multicopper ferroxidase required for Fe(2+) ion high affinity uptake. Required to oxidize Fe(2+) to Fe(3+), which is then transported into the cell via the ferric iron permease FTR1. Essential component of copper-dependent iron transport.
messages: Present with 1050 molecules/cell in log phase SD medium.

559292:YHR078W
gene id: 559292:YHR078W
uniprot id: P38799
names: Subcellular Location Annotation
messages: Membrane

559292:YLR020C
gene id: 559292:YLR020C
uniprot id: Q07950
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Cell membrane
messages: Mediates the hydrolysis of steryl esters. Required for mobilization of steryl ester, thereby playing a central role in lipid metabolism.
messages: Not glycosylated.
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YCR040W
gene id: 559292:YCR040W
uniprot id: P0CY06
uniprot id: P0CY07
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MATALPHA1 family.
messages: Binds DNA with a high specificity in complex with an MCM1 dimer. Interacts with STE12.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of ALPHA1 at HML.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional coactivator that, in alpha-cells, binds cooperatively with MCM1 and STE12 to a DNA sequence termed the QP' element, to activate the transcription of alpha-specific genes.
messages: Nucleus
messages: Only present in alpha-cells.
messages: Repressed in a/alpha diploid cells by A1/ALPHA2.
messages: There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.

559292:YLR215C
gene id: 559292:YLR215C
uniprot id: Q05791
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Interacts with DMA1, DMA2 and GCD11.
messages: Present with 4850 molecules/cell in log phase SD medium.
messages: Regulates the cell cycle in a nutrient dependent manner. Accumulates in presence of nutrients and directs the destabilization of DMA1 and DMA2, whose accumulation results in a G1 block. Regulates also the abundance of GCD11 an essential component of the translational initiation factor 2.

559292:YLR142W
gene id: 559292:YLR142W
uniprot id: P09368
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.
messages: Mitochondrion matrix
messages: Present with 184 molecules/cell in log phase SD medium.
messages: Proline oxidase requires a functional electron transport chain aerobiosis for its activity.
messages: The expression of proline oxidase is controlled by proline and oxygen.

559292:YOR340C
gene id: 559292:YOR340C
uniprot id: P46669
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Interacts with RPO26/ABC23 and with the initiation factor RRN3.
messages: Contains an average of four phosphates per molecule.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Through its association with RRN3 is involved in recruitment of Pol I to rDNA promoters. In vitro, the A13-A43 subcomplex binds single-stranded RNA.
messages: Present with 4070 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR098C
gene id: 559292:YDR098C
uniprot id: Q03835
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutaredoxin family. Monothiol subfamily.
messages: Homodimer. Heterodimer with FRA2.
messages: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable).
messages: Present with 11000 molecules/cell in log phase SD medium.

559292:YMR137C
gene id: 559292:YMR137C
uniprot id: P30620
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Expression is increased by ultraviolet light and agents which induce DNA cross-links such as nitrogen mustard and psoralen.
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.
messages: Required for DNA interstrand cross-link repair. This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs). This protein has 5' exonuclease activity on single-stranded and double-stranded DNA, which appears to be necessary for the processing of DNA double strand breaks prior to ligation.

559292:YHR071W
gene id: 559292:YHR071W
uniprot id: P38794
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the cyclin family. PCL1,2 subfamily.
messages: By transcription factor GCN4. Rapidly degraded under starvation conditions.
messages: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Positively controls degradation of transcription factor GCN4 under favorable growth conditions. The PCL5-PHO85 cyclin-CDK holoenzyme phosphorylates GCN4, which is required for its degradation by the E3 ubiquitin ligase complex SCF(Cdc4). Amino acid starvation reduces PCL5-PHO85-associated GCN4 kinase activity and leads to stabilization of GCN4.
messages: Forms a cyclin-CDK complex with PHO85.

559292:YDL031W
gene id: 559292:YDL031W
uniprot id: Q12389
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: Interacts with RRP1 and associates with pre-ribosomal particles.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

559292:YHL012W
gene id: 559292:YHL012W
uniprot id: P38709
names: Function
names: Similarity
messages: Belongs to the UDPGP type 1 family.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.

559292:YPL060C-A
gene id: 559292:YPL060C-A
uniprot id: A0A0B7P3V8
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.
messages: Could be the product of a pseudogene. Transposon Ty4-P (YPLCTy4-1) contains a frameshift at position 1105, which disrupts the ORF coding for protein TY4B. It is probably not functional.
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein.
messages: Nucleus
messages: Proteolytically processed into capsid protein (CA), Ty4 protease (PR), integrase (IN) and reverse transcriptase/ribonuclease H (RT) proteins (By similarity). Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein, and this cleavage is a prerequisite for subsequent processing at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty4 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The protease is a homodimer, whose active site consists of two apposed aspartic acid residues.

559292:YDR126W
gene id: 559292:YDR126W
uniprot id: Q04629
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs SNC1, SNC2, SYN8 and TLG1, at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins.
messages: The DHHC domain is required for palmitoyltransferase activity.

559292:YKR064W
gene id: 559292:YKR064W
uniprot id: P36023
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OAF3 family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus
messages: Present with 149 molecules/cell in log phase SD medium.
messages: Transcriptional inhibitor with a significantly increased number of target genes in response to oleate.

559292:YDR479C
gene id: 559292:YDR479C
uniprot id: Q03370
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEX28-32 family. PEX29 subfamily.
messages: Involved in the regulation of peroxisome number, size and distribution.
messages: Peroxisome membrane
messages: Present with 5040 molecules/cell.

559292:YGR225W
gene id: 559292:YGR225W
uniprot id: P50082
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). Required for the ubiquitination and subsequent degradation of the B-type cyclin CLB1 by the APC/C complex during meiosis. Required for meiosis I, late meiotic gene expression and spore wall assembly.
messages: Belongs to the WD repeat CDC20/Fizzy family.
messages: Expressed and spliced only during meiosis dependent on the splicing factor MER1.
messages: Interacts with CDC16.
messages: The C-box is required for the association with the APC/C complex.

559292:YGL086W
gene id: 559292:YGL086W
uniprot id: P40957
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Becomes hyperphosphorylated when wild-type cells are arrested in mitosis. Phosphorylated by MPS1.
messages: Belongs to the MAD1 family.
messages: Central component of the spindle assembly checkpoint. Thought to recruit MAD2 to unattached kinetochores. During checkpoint activity, MAD2 is relayed from the MAD1-MAD2 complex to the mitotic checkpoint complex (MCC). The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.
messages: Forms a stable heteromer with MAD2 throughout the cell cycle. Part of complex consisting of MAD1, BUB1 and BUB3 after activation of spindle checkpoint.
messages: Nucleus
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YDL174C
gene id: 559292:YDL174C
uniprot id: P32891
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Binds 2 FAD.
messages: By D-lactate. Induced during respiratory adaptation.
messages: Catalyzes the stereospecific oxidation of D-lactate to pyruvate.
messages: Mitochondrion inner membrane
messages: Present with 10800 molecules/cell in log phase SD medium.

559292:YPL239W
gene id: 559292:YPL239W
uniprot id: P46683
names: Function
names: Miscellaneous
messages: Present with 13100 molecules/cell in log phase SD medium.
messages: Required for normal rate of cell proliferation.

559292:YPL203W
gene id: 559292:YPL203W
uniprot id: P06245
names: Activity Regulation
names: Miscellaneous
names: Similarity
messages: Activated by cAMP.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Present with 2220 molecules/cell in log phase SD medium.

559292:YML107C
gene id: 559292:YML107C
uniprot id: Q03760
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLP1 and MLP2.
messages: Involved in the nuclear retention of improperly spliced pre-mRNAs.
messages: Nucleus membrane
messages: Present with 2205 molecules/cell in log phase SD medium.

559292:YOL164W
gene id: 559292:YOL164W
uniprot id: Q08347
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Alkyl/aryl-sulfatase. Enables the use of SDS and 4-nitrocatechol as sulfur source.
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Expression is increased in sulfur-limited chemostat cultures.
messages: The presence of this bacterial-like protein in S.cerevisiae results probably from a recent horizontal gene transfer event.

559292:YMR243C
gene id: 559292:YMR243C
uniprot id: P20107
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Contains 3 histidine repeat motifs between the 4th and 5th transmembrane, exposed to the cytoplasm, that may be involved in the binding site of zinc.
messages: Expression is induced in zinc-limited conditions by the zinc-responsive transcription factor ZAP1.
messages: Present with 8200 molecules/cell in log phase SD medium.
messages: Reduces zinc transport into the vacuole and hence limits the over-accumulation of zinc caused by the deletion of ZRT3.
messages: Vacuolar transporter that regulates zinc homeostasis by mediating zinc transport and storage into the vacuole (PubMed:2693940, PubMed:10856230, PubMed:11263974, PubMed:12161436, PubMed:12556516, PubMed:18930916). ZRC1 senses zinc availability in the cytosol, which might be performed through the histidine repeat motifs, and transports zinc from the cytosol to the vacuole if zinc in cytosol is abundant, confering resistance to zinc toxicity (PubMed:11263974). Plays a role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm when ZRT1 and ZRT2 are induced in response to zinc depletion (PubMed:11263974, PubMed:12556516).
messages: Vacuole membrane
messages: ZRC1 has a paralog, COT1, that arose from the whole genome duplication.

559292:YOR115C
gene id: 559292:YOR115C
uniprot id: Q99394
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.
messages: Preautophagosomal structure
messages: cis-Golgi network

559292:YLR436C
gene id: 559292:YLR436C
uniprot id: Q06673
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 1080 molecules/cell in log phase SD medium.
messages: Seems to be involved in cell wall organization and biogenesis.

559292:YBL025W
gene id: 559292:YBL025W
uniprot id: P38204
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the UAF (upstream activation factor) complex which consists of UAF30, RRN5, RRN9, RRN10, and histones H3 and H4.
messages: Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
messages: nucleolus

559292:YDR135C
gene id: 559292:YDR135C
uniprot id: P39109
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates.
messages: Present with 396 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YBR086C
gene id: 559292:YBR086C
uniprot id: P38250
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with BTN2.
messages: May be involved in ion homeostasis together with BTN1 or BTN2.

559292:YDR070C
gene id: 559292:YDR070C
uniprot id: Q12497
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Induced under aerobic conditions and by mild heat stress.
messages: Mitochondrion
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YDR172W
gene id: 559292:YDR172W
uniprot id: P05453
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
messages: Cytoplasm
messages: Heterodimer of two subunits, one of which binds GTP. Interacts with polyadenylate-binding protein PAB1, and TPA1.
messages: Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides. Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs. Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.
messages: Present with 78900 molecules/cell in log phase SD medium.
messages: The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.
messages: [PSI+] is the prion form of SUP35 (PubMed:8978027). [PSI+] is the result of a conformational change of the cellular SUP35 protein that becomes self-propagating and infectious. This conformational change generates a form of SUP35 that assembles into amyloid fibrils. [PSI+]-aggregates sequester soluble SUP35, resulting in defects in faithful translation termination by read-through of translation termination codons (PubMed:8670813). [PSI+] can be cured by GdnHCl and by deletion of the molecular chaperone HSP104, which is required for [PSI+] propagation (PubMed:9335589). It is speculated that the prion form would be at least mildly deleterious in most environments, but it might sometimes increase evolvability in certain harsh environments (PubMed:19917766).

559292:YJL165C
gene id: 559292:YJL165C
uniprot id: P38970
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NPR/HAL subfamily. HAL5 sub-subfamily.
messages: Protein kinase involved in salt tolerance and pH sensitivity, probably by regulating plasma membrane potential and cation influx. Positively controls the TRK1-TRK2 potassium transport system in response to potassium starvation. Stabilizes TRK1 in the plasma membrane by preventing its vacuolar sorting and degradation. Also stabilizes other plasma membrane nutrient transporters like CAN1, FUR4 and HXT1. May itself be subject to regulation by ARL1.

559292:YJL091C
gene id: 559292:YJL091C
uniprot id: P47026
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins.
messages: Target of the antifungal compound 1-[4-butylbenzyl]isoquinoline that inhibits cell wall localization of GPI-anchored mannoproteins.

559292:YHR121W
gene id: 559292:YHR121W
uniprot id: P38828
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LSM12 family.
messages: Cytoplasm
messages: Interacts with IGO1, PBP1 and PBP4.
messages: Nucleus
messages: Present with 8320 molecules/cell in log phase SD medium.

559292:YGL103W
gene id: 559292:YGL103W
uniprot id: P02406
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

559292:YLR081W
gene id: 559292:YLR081W
uniprot id: P13181
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: GAL2 is a facilitated diffusion transporter required for both the high-affinity galactokinase-dependent and low-affinity galactokinase-independent galactose transport processes.
messages: Membrane

559292:YJL112W
gene id: 559292:YJL112W
uniprot id: P47025
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat MDV1/CAF4 family.
messages: Interacts with CAF4, DNM1 and FIS1, components of the mitochondrial fission machinery. Interacts via its N-terminal, coiled-coil extension (NTE) with FIS1, and via its WD repeats with DNM1.
messages: Involved in mitochondrial fission. Has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.
messages: Mitochondrion outer membrane
messages: Present with 3730 molecules/cell in log phase SD medium.

559292:YHR127W
gene id: 559292:YHR127W
uniprot id: P38833
names: Miscellaneous
messages: Present with 2140 molecules/cell in log phase SD medium.

559292:YOL122C
gene id: 559292:YOL122C
uniprot id: P38925
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: High-affinity manganese transporter involved in manganese uptake from the extracellular environment. Contributes also to cellular accumulation of other divalent metal ions such as cadmium, cobalt, copper, iron and nickel.

559292:YNL316C
gene id: 559292:YNL316C
uniprot id: P32452
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: By L-phenylalanine.
messages: Catayzes the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm
messages: Present with 2020 molecules/cell in log phase SD medium.

559292:YLR264W
gene id: 559292:YLR264W
uniprot id: P0C0X0
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatB.
messages: Present with 8600 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS28 in yeast.

559292:YGR028W
gene id: 559292:YGR028W
uniprot id: P28737
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. MSP1 subfamily.
messages: Homohexamer; in presence of ATP (PubMed:30858337, PubMed:32541053, PubMed:28712723). Interacts with PEX3; leading to inhibit the translocase activity (PubMed:28906250, PubMed:32541053).
messages: Impaired transmembrane tail-anchored protein localization, characterized by mislocalization of PEX15 to the mitochondrion outer membrane.
messages: Interaction with PEX3 inhibits the translocase activity by preventing unfolding of target proteins.
messages: Mitochondrion outer membrane
messages: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043, PubMed:24821790, PubMed:28906250, PubMed:30858337, PubMed:31445887, PubMed:28712723). Specifically recognizes and binds exposed hydrophobic surfaces of mistargeted tail-anchored transmembrane proteins (PubMed:30858337). Acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (PubMed:24843043, PubMed:24821790, PubMed:28906250, PubMed:30858337, PubMed:32541053, PubMed:28712723). Able to unfold protein substrates by processive threading through its central pore (PubMed:32541053). Once extracted from the mitochondrion outer membrane, substrate proteins are then transferred to the endoplasmic reticulum, where they are ubiquitinated and degraded by the proteasome (PubMed:31445887). Also mediates extraction of excess tail-anchored proteins from the peroxisomal membrane (PubMed:28906250). In normal conditions, MSP1 translocase activity is inhibited by PEX3 at peroxisomes; only catalyzes removal of excess tail-anchored proteins (PubMed:28906250).
messages: Peroxisome membrane
messages: Present with 3530 molecules/cell in log phase SD medium.

559292:YLR056W
gene id: 559292:YLR056W
uniprot id: P32353
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sterol desaturase family.
messages: C-5 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1864507). ERG3 catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol (PubMed:1864507). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. …
messages: Endoplasmic reticulum membrane
messages: Interacts with ERG28.
messages: Present with 36200 molecules/cell in log phase SD medium.
messages: The ERG3 promoter contains 2 upstream activation sequences, UAS1 and UAS2 (PubMed:8772195). UAS1 regulates gene expression but does not affect sterol regulation (PubMed:8772195). UAS2 is required for sterol regulation (PubMed:8772195). The absence of sterol esterification leads to a decrease of ERG3 expression (PubMed:8772195).
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

559292:YGL234W
gene id: 559292:YGL234W
uniprot id: P07244
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Binds two magnesium or manganese ions per subunit.
messages: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the AIR synthase family.
messages: In the N-terminal section; belongs to the GARS family.
messages: Present with 35800 molecules/cell in log phase SD medium.

559292:YPL135W
gene id: 559292:YPL135W
uniprot id: Q03020
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NifU family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Cells deleted for both ISU1 and ISU2 have decreased activity of several respiratory enzymes that contain Fe-S clusters. As a result, cells grow poorly on carbon sources requiring respiration and also accumulate abnormally high levels of iron in their mitochondria. Knockdown of ISU1 in ISU2 knockout cells decreases cytosolic tRNA thiolation, and increases association between SSQ1 and GRX5 (PubMed:31040179, PubMed:23615440).
messages: Component of the core Fe-S cluster (ISC) assembly machinery. Interacts with frataxin (PubMed:14741370, PubMed:12947415, PubMed:20815377, PubMed:25228696). Interacts with the mitochondrial co-chaperones JAC1 and SSQ1 (PubMed:12756240, PubMed:15123690, PubMed:22306468, PubMed:23946486, PubMed:23615440). Interacts with NFS1 (PubMed:23946486, PubMed:25228696). Interacts with ferredoxin YAH1; interacts with the reduced form (PubMed:25358379).
messages: Mitochondrion matrix
messages: Present with 10800 molecules/cell in log phase SD medium.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2. In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH. Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1. ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (PubMed:10588895, PubMed:12970193, PubMed:14741370, PubMed:15123690, PubMed:16341089, PubMed:16431909, PubMed:23615440, PubMed:25358379). Also involved in production of a sulfur precursor required for thiolation of cytoplasmic tRNAs (PubMed:31040179).

559292:YHR195W
gene id: 559292:YHR195W
uniprot id: P38881
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with OSH1, TSC13 and VAC8.
messages: Involved in the formation of nucleus-vacuole (NV) junctions during piecemeal microautophagy of the nucleus (PMN). NV junctions are interorganelle interfaces mediated by NVJ1 in the nuclear envelope and VAC8 on the vacuole membrane. Together, NVJ1 and VAC8 form Velcro-like patches through which teardrop-like portions of the nucleus are pinched off into the vacuolar lumen and degraded by the PMN process. Acts also as an outer-nuclear membrane receptor for OSH1 and TSC13.
messages: Nucleus outer membrane
messages: Present with 1900 molecules/cell in log phase SD medium.

559292:YIL096C
gene id: 559292:YIL096C
uniprot id: P40493
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BMT5 family.
messages: Present with 2960 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(3) position of uridine 2634 (m3U2634) in 25S rRNA.
messages: nucleolus

559292:YDR228C
gene id: 559292:YDR228C
uniprot id: P39081
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the CFIA complex, which is composed of RNA14, RNA15, PCF11 and CLP1. Interacts with RNA14, RNA15 and RTT103. Interacts directly with the phosphorylated CTD domain of RPB1/RNA polymerase II.
messages: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex. Independently involved in RNA polymerase II transcript termination. Binds RNA. Seems to bridge RNA polymerase II and the native transcript and may be involved in dismantling the RNA polymerase II elongation complex.
messages: Nucleus
messages: Present with 2800 molecules/cell in log phase SD medium.

559292:YGR005C
gene id: 559292:YGR005C
uniprot id: P41896
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: Present with 520 molecules/cell in log phase SD medium.
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation.
messages: TFIIF is composed of three different subunits: TFG1/RAP74, TFG2/RAP30 and TAF14.

559292:YKL012W
gene id: 559292:YKL012W
uniprot id: P33203
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRPF40 family.
messages: Interacts with CRM1, MSL5, PRP8, and the RNA polymerase II largest subunit (RPB1). MSL5, MUD2 and PRP40 interact to form the commitment complex 2 (CC2), a precursor of mature spliceosomes.
messages: Nucleus
messages: Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.
messages: The WW and FF domains bind to the phosphorylated carboxy-terminal domain of RPB1.

559292:YFR007W
gene id: 559292:YFR007W
uniprot id: P43591
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: ATP-dependent kinase that could be involved in endoplasmic reticulum membrane assembly.
messages: Belongs to the YFH7 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Present with 161 molecules/cell in log phase SD medium.

559292:YER190C-B
gene id: 559292:YER190C-B
uniprot id: P0CX94
uniprot id: P0CX95
uniprot id: P0CX96
uniprot id: P0CX97
uniprot id: P0CX98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0479 family.
messages: Membrane

559292:YPL091W
gene id: 559292:YPL091W
uniprot id: P41921
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Impairs glutathione reductase activity.
messages: Maintains high levels of reduced glutathione in the cytosol.
messages: Present with 7600 molecules/cell in log phase SD medium.
messages: The active site is a redox-active disulfide bond.

559292:YNR050C
gene id: 559292:YNR050C
uniprot id: P38999
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the saccharopine dehydrogenase family.
messages: Interacts with TRM112.
messages: Present with 57500 molecules/cell in log phase SD medium.

559292:YMR296C
gene id: 559292:YMR296C
uniprot id: P25045
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: LCB1 and LCB2 encode essential subunits of the enzyme and form a heterodimer. Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. Interacts with LCB2 and TSC3.
messages: Present with 22400 molecules/cell in log phase SD medium.
messages: The first transmembrane domain is not required for stability, membrane association, interaction with LCB2, or enzymatic activity. The second and third transmembrane domains are required for stability and interaction with LCB2.

559292:YML002W
gene id: 559292:YML002W
uniprot id: P0CF17
names: Caution
names: Similarity
messages: Belongs to the UPF0507 family.
messages: This is a truncated version of an UPF0507 family protein. Strain S288c has a frameshift in position 286, which disrupts the gene coding for this protein and produces two ORFs YML003W and YML002W. A contiguous sequence for a S.cerevisiae UPF0507 family protein can be found in strain YJM789 (AC A6ZM60).

559292:YPR100W
gene id: 559292:YPR100W
uniprot id: Q06090
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable). Also has an extraribosomal function, being essential for mitochondrial genome integrity. May interact with MHR1 to take part in the mtDNA repair mechanism (PubMed:25609543).
messages: Has a respiratory growth defect. Shows complete loss of growth on nonfermentable carbon source and a gradual loss of mtDNA with replicative cell growth and an increasing number of generations.
messages: Mitochondrion
messages: Present with 3400 molecules/cell in log phase SD medium.

559292:YDR210C-D
gene id: 559292:YDR210C-D
uniprot id: Q99231
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YDR210C-C ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YDL122W
gene id: 559292:YDL122W
uniprot id: P25037
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin.
messages: Present with 8970 molecules/cell in log phase SD medium.

559292:YGR276C
gene id: 559292:YGR276C
uniprot id: P53331
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3' exoribonuclease required for 5S rRNA maturation and for the proper maturation of the 5' cistron of the tRNA-Arg3 dicistronic gene. Involved with REX2 in the maturation of the 5.8S rRNA, and with REX2 and REX3, in the 3' processing of the U5L snRNA.
messages: Belongs to the REXO1/REXO3 family.
messages: Nucleus

559292:YLR370C
gene id: 559292:YLR370C
uniprot id: Q05933
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Present with 1920 molecules/cell in log phase SD medium.
messages: cytoskeleton

559292:YER061C
gene id: 559292:YER061C
uniprot id: P39525
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Mitochondrion
messages: Possibly involved in the synthesis of a specialized molecule, probably related to a fatty acid, which is essential for mitochondrial respiration. Is essential for oxygen uptake and the presence of cytochromes A and B.
messages: Present with 1660 molecules/cell in log phase SD medium.

559292:YLR210W
gene id: 559292:YLR210W
uniprot id: P24871
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
messages: Present with 98 molecules/cell in log phase SD medium.

559292:YOL097C
gene id: 559292:YOL097C
uniprot id: Q12109
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.
messages: Present with 12100 molecules/cell in log phase SD medium.

559292:YFL017W-A
gene id: 559292:YFL017W-A
uniprot id: P40204
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the Sm core complex, present in spliceosomal snRNP U1, U2, U4/U6 and U5. The core complex contains SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively), and is probably a heptameric ring structure. SMX2 specifically interacts with SME1. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: Present with 1400 molecules/cell in log phase SD medium.

559292:YHR036W
gene id: 559292:YHR036W
uniprot id: P38770
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRL1/BRR6 family.
messages: Interacts with BRR6.
messages: Involved in mRNA and protein export from nucleus.
messages: Nucleus membrane
messages: Present with 1280 molecules/cell in log phase SD medium.

559292:YIL114C
gene id: 559292:YIL114C
uniprot id: P40478
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules.
messages: Mitochondrion outer membrane

559292:YGR253C
gene id: 559292:YGR253C
uniprot id: P32379
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 17100 molecules/cell in log phase SD medium.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

559292:YMR049C
gene id: 559292:YMR049C
uniprot id: Q04660
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. Also interacts with NOG1.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Present with 2680 molecules/cell in log phase SD medium.
messages: nucleolus
messages: nucleoplasm

559292:YDR500C
gene id: 559292:YDR500C
uniprot id: P51402
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Present with 19700 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL37 in yeast.

559292:YGL200C
gene id: 559292:YGL200C
uniprot id: P32803
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with ERV25, ERP1 and ERP2. Interacts also with SAR1, SEC23 and SEC24.
messages: Belongs to the EMP24/GP25L family.
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Present with 26800 molecules/cell in log phase SD medium.

559292:YHR196W
gene id: 559292:YHR196W
uniprot id: P38882
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
messages: Present with 20000 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YPL170W
gene id: 559292:YPL170W
uniprot id: Q12091
names: Domain
names: Miscellaneous
names: Similarity
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Present with 6300 molecules/cell in log phase SD medium.
messages: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 81 and 105.

559292:YKL061W
gene id: 559292:YKL061W
uniprot id: P35727
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLI1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Endosome
messages: Present with 1240 molecules/cell in log phase SD medium.

559292:YOL034W
gene id: 559292:YOL034W
uniprot id: Q08204
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6.
messages: Nucleus
messages: Present with 892 molecules/cell in log phase SD medium.
messages: Sumoylated by MMS21.
messages: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of smc6, forming a V-shaped heterodimer.

559292:YNL207W
gene id: 559292:YNL207W
uniprot id: P40160
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Component of a late pre-40S ribosomal particle, composed of the 40S ribosomal proteins and the non-ribosomal factors DIM1, DIM2, ENP1, HRR25, LTV1, NOB1, RIO2 and TSR1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 10300 molecules/cell in log phase SD medium.
messages: Required for the final endonucleolytic cleavage of 20S pre-rRNA at site D in the cytoplasm, converting it into the mature 18S rRNA. Involved in normal export of the pre-40S particles from the nucleus to the cytoplasm. No longer associates with pre-40S subunits in RPS19 disruptions, suggesting it acts after the ribosomal protein in 18S rRNA maturation.

559292:YOR096W
gene id: 559292:YOR096W
uniprot id: P26786
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS7 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). Interacts with snoRNA U3. uS11 interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Present with 41000 molecules/cell in log phase SD medium.
messages: There are 2 genes for eS7 in yeast.
messages: nucleolus

559292:YMR028W
gene id: 559292:YMR028W
uniprot id: Q04372
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Associates with the PP2a (PPH21 and PPH22) and SIT4 protein phosphatase catalytic subunits. Interacts with PPG1, PPH3 and TIP41.
messages: Belongs to the IGBP1/TAP42 family.
messages: Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Inhibitor of PP2A phosphatase SIT4, which results in inhibition of nuclear export of MSN2, due to lack of dephosphorylation by SIT4. Also required for rapamycin induced activation of expression of many nitrogen discrimination pathway (NDP) genes. In complex with PPH21, required for organization of the actin cytoskeletom during the cell cycle via a Rho GTPase-dependent mechanism.
messages: Phosphorylated by TOR kinases. Dephosphorylated by CDC55, TPD3 and SIT4.

559292:YDL110C
gene id: 559292:YDL110C
uniprot id: Q12513
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: ATPase-dedicated chaperone that assists the formation of the RPT6-RPT3 ATPase pair, an early step in proteasome assembly. Plays a key role in maintaining homeostatic proteasome levels and adjusting proteasome assembly when demands increase, such as during proteasome stresses. Function overlaps with RPN14.
messages: Cytoplasm
messages: Decreases cell fitness. Causes severe growth defects and an overload of polyubiquitinated conjugates when associated with a RPT6 thermosensitive proteasome mutant.
messages: Expression is increased in absence of RPN14 and upon treatment with tunicamycin, an agent which causes accumulation of misfolded proteins in the endoplasmic reticulum.
messages: Interacts with RPT6. Interacts with the 40S and 60S ribosomal subunits.
messages: Nucleus
messages: Present with 2110 molecules/cell in log phase SD medium.

559292:YDR012W
gene id: 559292:YDR012W
uniprot id: P49626
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL4 is associated with the polypeptide exit tunnel (PubMed:9559554, PubMed:22096102). uL4 interacts with its chaperone ACL4 and the nuclear import receptor KAP104 (PubMed:25936803).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: N-terminally acetylated by acetyltransferase NatA.
messages: Nucleus
messages: Present with 151000 molecules/cell in log phase SD medium.
messages: The eukaryote-specific C-terminal extension harbors a nuclear import signal and delivers the ACL4-uL4/RPL4 complex to the pre-ribosome, triggering uL4 release from ACL4 and incorporation into the 60S ribosomal subunit.
messages: There are 2 genes for uL4 in yeast.

559292:YLR033W
gene id: 559292:YLR033W
uniprot id: Q07979
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.
messages: Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
messages: Nucleus
messages: Present with 4460 molecules/cell in log phase SD medium.

559292:YGL250W
gene id: 559292:YGL250W
uniprot id: P53060
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMR1 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1820 molecules/cell in log phase SD medium.
messages: Required for normal levels of gene conversion events during meiosis.
messages: Sumoylated.

559292:YDL045W-A
gene id: 559292:YDL045W-A
uniprot id: O75012
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS37 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Mitochondrion
messages: Mitochondrion matrix
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YMR204C
gene id: 559292:YMR204C
uniprot id: Q03694
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INP1 family.
messages: Interacts with PEX25, PEX30 and VPS1.
messages: Peroxisome membrane
messages: Present with 639 molecules/cell in log phase SD medium.
messages: Required for peroxisome inheritance.

559292:YPL264C
gene id: 559292:YPL264C
uniprot id: Q08980
names: Subcellular Location Annotation
messages: Membrane

559292:YOL063C
gene id: 559292:YOL063C
uniprot id: Q08226
names: Function
names: Induction
names: Miscellaneous
names: Subunit
messages: By DNA damage and hydroxyurea (HU).
messages: Component of a cullin-RING ligase (CRL) composed of 4 subunits: the RING protein HRT1, the cullin RTT101, a linker protein MMS1, and the substrate receptor CRT10. Interacts with MMS1.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-CRT10). RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of RNR genes encoding ribonucleotide reductases.

559292:YPR171W
gene id: 559292:YPR171W
uniprot id: Q06604
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cortical patch protein involved in endocytosis. May serve as an adapter to link INP52 and INP53 to the cortical actin cytoskeleton.
messages: Interacts with CAP1, RVS167, SLA1, INP52 and INP53. The INP52 and INP53 C-terminal Sac1 domains are required for the binding with BSP1.
messages: Phosphorylated by CDC28.
messages: Present with 704 molecules/cell in log phase SD medium.
messages: actin patch

559292:YDL127W
gene id: 559292:YDL127W
uniprot id: P25693
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. PCL1,2 subfamily.
messages: By transcription factors SBF (SWI4-SWI6 cell-cycle box binding factor) and SWI5 in a cell cycle-regulated manner. Peaks in G1 phase.
messages: Cytoplasm
messages: Forms a cyclin-CDK complex with PHO85. Interacts with RVS167.
messages: G1/S-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Essential for the control of the cell cycle at the G1/S (start) transition. Together with cyclin PCL1, positively controls degradation of sphingoid long chain base kinase LCB4. The PCL2-PHO85 cyclin-CDK holoenzyme phosphorylates LCB4, which is required for its ubiquitination and degradation. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton.
messages: Nucleus

559292:YGL192W
gene id: 559292:YGL192W
uniprot id: P41833
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Catalytic component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation on some mRNAs during meiosis and is required for sporulation. M6A, which takes place on the adenosine of 5'-[AG]GAC-3' consensus sites of some mRNAs, is probably required to initiate sporulation. Positive regulator for IME2.
messages: Component of the MIS complex, composed of SLZ1, MUM2 and IME4.
messages: Cytoplasm
messages: In response to starvation conditions.
messages: nucleolus

559292:YKR009C
gene id: 559292:YKR009C
uniprot id: Q02207
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Contains two SDR domains.
messages: Monomer.
messages: Peroxisome
messages: Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.

559292:YJL081C
gene id: 559292:YJL081C
uniprot id: P80428
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP4 subfamily.
messages: Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. ARP4 recognizes H2AS128ph (gamma-H2A) and is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes. Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates. The INO80 complex is involved in DNA repair by associating to gamma-H2A as a response to DNA damage.
messages: Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, SWC4, TRA1, VID21, YAF9 and YNG2. Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1. Interacts with histones H4 (HHF1 and HHF2), H3 (HHT1 and HHT2) and H2A (HTA1 and HTA2).
messages: Nucleus
messages: Present with 1070 molecules/cell in log phase SD medium.

559292:YPL096C-A
gene id: 559292:YPL096C-A
uniprot id: P62651
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1 (Probable). Interacts with GPI2 (PubMed:15163411). Interacts with GTP-bound RAS2 in an effector loop-dependent manner (PubMed:12832483).
messages: Defects cause hyperactive Ras phenotypes, probably due to diminished GPI-anchor protein production.
messages: Endoplasmic reticulum membrane
messages: Probable component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. Ras may inhibit the enzyme activity of the GPI-GnT complex via the association between ERI1 and RAS2.

559292:YDR504C
gene id: 559292:YDR504C
uniprot id: Q04398
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Required for survival during stationary phase.

559292:YGL023C
gene id: 559292:YGL023C
uniprot id: P53191
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal activation of TORC1 signaling in nitrogen-replete conditions (glutamine or leucine nitrogen source), and during high hydrostatic pressure (mechanical stress) (PubMed:28993463, PubMed:29698392, PubMed:28483912, PubMed:32801125). Increases cellular levels of glutamine and alanine during high hydrostatic pressure (mechanical stress) (PubMed:32801125). Sensitive to rapamycin (TORC1 signaling-inhibitor), caffeine, and high hydrostatic pressure (mechanical stress) (PubMed:28993463, PubMed:29698392, PubMed:34535752, PubMed:26510498, PubMed:32801125). Abnormal TORC1-reactivation following inactivaton by rapamycin (TORC1 signaling-inhibitor) (PubMed:28993463). Resistance to tunicamycin (endoplasmic reticulum stressor) administered together with FK506 (calcineurin inhibitor) (PubMed:26510498). Abnormal localization of TOR1 to vacuoles (PubMed:28993463). Localization of GTR1 and GTR2 to vacuoles is normal (PubMed:28993463) Localization of TORC1 to vacuoles is normal (PubMed:28483912). Simultaneous disruption of GTR1 results in TOR1 mislocalization and loss of TORC1 activity and viability (PubMed:29698392). Simultaneous disruption of EGO1 results in loss of viability (PubMed:29698392). Macroautophagy appears normal (PubMed:28993463).
messages: Activated by glutamine (PubMed:34535752, PubMed:29698392). May also be activated by cysteine (PubMed:34535752).
messages: Functions as an intracellular glutamine sensor that directly activates the TORC1 signaling pathway, to promote cell growth when glutamine is available (PubMed:34535752, PubMed:29698392, PubMed:28483912, PubMed:26510498, PubMed:32801125). May play a role in repressing NPR1 activity independently of TORC1 signaling (PubMed:28993463).
messages: Interacts with the TORC1 complex when activated by glutamine or cysteine (PubMed:34535752, PubMed:29698392, PubMed:28483912). Interacts with TOR1; glutamine enhances the interaction (PubMed:34535752, PubMed:29698392, PubMed:28483912). Interacts with KOG1; glutamine enhances the interaction (PubMed:29698392). Interacts with TCO89 (PubMed:29698392). Interacts with LST8; glutamine enhances the interaction (PubMed:29698392). Interacts with TOR2; glutamine enhances the interaction (PubMed:29698392).
messages: The FYVE-type zinc finger domain contributes to vacuolar localization.
messages: Vacuole membrane

559292:YHR151C
gene id: 559292:YHR151C
uniprot id: P38849
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTC6 family.
messages: May be involved in telomere capping.
messages: Membrane

559292:YMR172W
gene id: 559292:YMR172W
uniprot id: Q03213
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HOT1 family.
messages: Hyperphosphorylated during acute stress.
messages: Interacts with HOG1.
messages: Nucleus
messages: Present with 149 molecules/cell in log phase SD medium.
messages: Required for a complete transcriptional response to osmotic stress, through recruitment of HOG1 followed by pol II recruitment to the promoters of GPD1 and other HOG-dependent genes.

559292:YBR164C
gene id: 559292:YBR164C
uniprot id: P38116
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Golgi apparatus
messages: Homodimer. Binds in a GTP-dependent manner to the GRIP domain of IMH1. Interacts with MON2.
messages: Present with 5190 molecules/cell in log phase SD medium.
messages: Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system.

559292:YBR180W
gene id: 559292:YBR180W
uniprot id: P38125
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: During sporulation.
messages: Phosphorylated.
messages: Prospore membrane
messages: Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore.

559292:YLR176C
gene id: 559292:YLR176C
uniprot id: P48743
names: Miscellaneous
names: Similarity
messages: Belongs to the RFX family.
messages: Present with 377 molecules/cell in log phase SD medium.

559292:YMR149W
gene id: 559292:YMR149W
uniprot id: Q02795
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:8175708, PubMed:16297388, PubMed:16096345, PubMed:15831493, PubMed:15886282, PubMed:9405463, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962). Interacts with SEC61 and SSS1 (PubMed:15831493).
messages: Endoplasmic reticulum membrane
messages: Present with 8450 molecules/cell in log phase SD medium.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

559292:YJR149W
gene id: 559292:YJR149W
uniprot id: P47177
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nitronate monooxygenase family. NMO class I subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites.
messages: Cytoplasm
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YGR024C
gene id: 559292:YGR024C
uniprot id: P53215
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.
messages: Present with 1170 molecules/cell in log phase SD medium.

559292:YLR206W
gene id: 559292:YLR206W
uniprot id: Q05785
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the epsin family.
messages: Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin.
messages: Cytoplasm
messages: Membrane
messages: Phosphorylated by PRK1.
messages: Present with 1970 molecules/cell in log phase SD medium.

559292:YHL047C
gene id: 559292:YHL047C
uniprot id: P38724
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Endosome membrane
messages: Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis.

559292:YNL131W
gene id: 559292:YNL131W
uniprot id: P49334
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom22 family.
messages: Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). Interacts with TOM20 and TOM70. Interacts with FCJ1.
messages: Its cytoplasmic domain associates with the cytoplasmic domains of TOM20 and TOM70. Its intermembrane space domain provides a trans binding site for presequences and the single membrane anchor is required for a stable interaction between the GIP complex proteins.
messages: Mitochondrion outer membrane
messages: Present with 6610 molecules/cell in log phase SD medium.

559292:YDL227C
gene id: 559292:YDL227C
uniprot id: P09932
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Initiation of mating type interconversion. This protein is a site-specific endonuclease that cleaves a site in the mat locus on chromosome III. The double-strand break is followed by a unidirectional gene conversion event that replaces the information at the mat locus by information copied from either of the two homologous loci (HMR and HML) that reside at the extremity of the chromosome III. Endonuclease expression takes place in late G1 just before cells enter S phase.
messages: Nucleus
messages: Rapidly degraded via the ubiquitin-26S proteasome system through two ubiquitin-conjugating enzymes UBC2/RAD6 and UBC3/CDC34.
messages: The metal-binding domain form zinc-fingers that are involved in binding of the DNA.

559292:YGL051W
gene id: 559292:YGL051W
uniprot id: P53176
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DUP/COS family.
messages: COPI-coated vesicle membrane
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Interacts with MST28. Binds to coatomer proteins of COPI and SEC23/SEC24 of COPII coated vesicles.
messages: Involved in protein trafficking vesicle formation, probably by stabilizing of coatomer at the Golgi membrane and thus allowing the efficient formation of COPI coated vesicles.
messages: Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.

559292:YJR093C
gene id: 559292:YJR093C
uniprot id: P45976
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIP1 family.
messages: Circular dichroism measurements suggest that the protein is largely unstructured in the absence of interaction with PAP1.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. In the CPF complex probably interacts directly with PAP1 and YTH1. Interacts with RNA14.
messages: Nucleus
messages: Polymerase-regulating component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase PAP1. This inhibits the extension of an oligo(A) primer by limiting access of the RNA substrate to the C-terminal RNA binding domain of PAP1. Seems to tether PAP1 to the cleavage factor I.
messages: Present with 1310 molecules/cell in log phase SD medium.

559292:YNL211C
gene id: 559292:YNL211C
uniprot id: P53869
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial ribosome.
messages: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.
messages: Mitochondrion

559292:YGL140C
gene id: 559292:YGL140C
uniprot id: P53120
names: Miscellaneous
names: Subcellular Location Annotation
messages: Membrane
messages: Present with 1080 molecules/cell in log phase SD medium.

559292:YOR037W
gene id: 559292:YOR037W
uniprot id: P38909
names: Cofactor
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Binds 1 FAD per monomer.
messages: Mitochondrion inner membrane
messages: Present with 2730 molecules/cell in log phase SD medium.
messages: Redox component that participates in c-type cytochrome biogenesis in the mitochondrial intermembrane space. May play a role in the reduction of heme prior to its ligation to apocytochrome c by cytochrome c heme lyase. Has oxidoreductase activity in vitro.

559292:YML100W
gene id: 559292:YML100W
uniprot id: P38427
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: C-terminal 700 AA are mainly in alpha-helices and beta-sheets.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the glycosyltransferase 20 family.
messages: Present with 1960 molecules/cell in log phase SD medium.
messages: Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex, and confer sensitivity to physiological concentrations of phosphate and to fructose 6-phosphate.
messages: Repressed by glucose.
messages: The trehalose synthase complex is composed of the two catalytic subunits TPS1 and TPS2, and at least one of the two regulatory subunits TPS3 or TSL1.

559292:YKL165C
gene id: 559292:YKL165C
uniprot id: P36051
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. Ethanolamine phosphate on the alpha-1,4-linked mannose is essential for further mannosylation by GPI10 and is necessary for an efficient recognition of GPI lipids and GPI proteins by the GPI transamidase, for the efficient transport of GPI anchored proteins from endoplasmic reticulum to Golgi and for the physiological incorporation of ceramides into GPI anchors by lipid remodeling. Also involved in non-mitochondrial ATP movements across membrane and participates in Golgi and endoplasmic reticulum function, Also required for the incorporation of BGL2 into the cell wall.
messages: Golgi apparatus membrane
messages: Interacts with CSF1; CSF1 channels phosphatidylethanolamine to MCD4 in the endoplasmic reticulum at contact sites to support GPI anchor biosynthesis.
messages: N-glycosylated.
messages: Target of the inhibitor of GPI biosynthesis YW3548/BE49385A.
messages: Vacuole membrane

559292:YGL080W
gene id: 559292:YGL080W
uniprot id: P53157
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Grows more slowly in amino acid-free medium (SD).
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Present with 396 molecules/cell in log phase SD medium.
messages: The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and either MPC2 or MPC3.

559292:YBR004C
gene id: 559292:YBR004C
uniprot id: P38211
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.
messages: Part of the GPI mannosyltransferase 2 complex composed of GPI18 and PGA1.

559292:YDL148C
gene id: 559292:YDL148C
uniprot id: Q99207
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP14 family.
messages: Interacts with snoRNA U3. Interacts with EMG1, MPP10 and NOC4. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

559292:YER104W
gene id: 559292:YER104W
uniprot id: P40063
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in regulation of Ty1 transposition. Inhibits Ty1 transposition at a post-transcriptional and pre-integrational stage of the Ty1 retrotransposition cycle.
messages: Nucleus
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YER046W
gene id: 559292:YER046W
uniprot id: P40031
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPO73 family.
messages: Cytoplasm
messages: Inteacts with SPO71.
messages: Prospore membrane
messages: Required for spore wall assembly and ascus formation (PubMed:11470404, PubMed:15590821). Involved in the formation and elongation of prospore membranes (PubMed:26605945, PubMed:27303688).

559292:YDR493W
gene id: 559292:YDR493W
uniprot id: Q03429
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.
messages: Belongs to the complex I LYR family. MZM1 subfamily.
messages: Interacts with RIP1.
messages: Leads to respiratory growth defect and increases frequency of mitochondrial genome loss.
messages: Mitochondrion matrix
messages: Present with 279 molecules/cell in log phase SD medium.

559292:YOR105W
gene id: 559292:YOR105W
uniprot id: Q08504
names: Miscellaneous
messages: Present with 3670 molecules/cell in log phase SD medium.

559292:YJR136C
gene id: 559292:YJR136C
uniprot id: P47168
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TTI2 family.
messages: Component of the ASTRA chromatin remodeling machinery complex composed of at least RVB1, RVB2, TRA1, TEL2, TT1 and TTI2. Component of the TTT complex composed of TEL2, TTI1 and TTI2. Interacts with TEL2 and TTI1.
messages: Component of the ASTRA complex probably in chromatin remodeling.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YLL003W
gene id: 559292:YLL003W
uniprot id: Q12369
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFI1 family.
messages: Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication.
messages: Forms a complex with CDC31 and interacts with SPC110. Associates with the spindle pole body half bridge.
messages: spindle pole

559292:YMR198W
gene id: 559292:YMR198W
uniprot id: Q01649
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: A developmentally regulated protein important for microtubule functions. Targets KAR3 to the cytoplasmic microtubules during mating. Essential for KAR3 function during prophase of meiosis I. Required for interhomolog recombination, synapsis of homologous chromosomes and establishment of a meiosis I spindle.
messages: By alpha factor.
messages: Interacts with KAR3.
messages: Nucleus
messages: Present with 98 molecules/cell in log phase SD medium.
messages: spindle pole body

559292:YKR030W
gene id: 559292:YKR030W
uniprot id: P36125
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the unc-50 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with GEA1 and GEA2.

559292:YPL076W
gene id: 559292:YPL076W
uniprot id: P46961
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGC family.
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1 (Probable). Interacts with ERI1 (PubMed:15163411).
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

559292:YHR094C
gene id: 559292:YHR094C
uniprot id: P32465
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Expression is maximal during lag and early exponential phases of growth, decreasing upon further entry into exponential growth.
messages: Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.
messages: Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose.
messages: Membrane
messages: Present with 23300 molecules/cell in log phase SD medium.
messages: Repressed at high glucose concentrations.

559292:YGL111W
gene id: 559292:YGL111W
uniprot id: P53136
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSA1 family.
messages: Component of the pre-66S ribosomal particle. Interacts with NOP7, RRP1 and RRP5.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: Present with 2740 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YCL034W
gene id: 559292:YCL034W
uniprot id: P25369
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LSB5 family.
messages: Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with YSC84.
messages: Interacts with SLA1 and LAS17.
messages: cell cortex
messages: cytoskeleton

559292:YDL167C
gene id: 559292:YDL167C
uniprot id: P32770
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Chromosome
messages: May play a role in chromatin organization.
messages: Nucleus
messages: Present with 3570 molecules/cell in log phase SD medium.

559292:YBL024W
gene id: 559292:YBL024W
uniprot id: P38205
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
messages: Methylates cytosine to m5C at several positions in different tRNAs and pre-tRNAs containing intron. Able to modify tRNAs at all four positions (34, 40, 48 and 49) at which m5C has been found in tRNAs. May be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin.
messages: Present with 16100 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YMR004W
gene id: 559292:YMR004W
uniprot id: P40959
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Interacts with VPS1.
messages: Membrane
messages: Present with 2210 molecules/cell in log phase SD medium.
messages: Required for vacuolar protein sorting.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

559292:YMR128W
gene id: 559292:YMR128W
uniprot id: Q04217
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Interacts with snoRNA U3. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Present with 2000 molecules/cell in log phase SD medium.
messages: Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis. May play a role in restructuring of the pre-rRNA.
messages: nucleolus

559292:YKL121W
gene id: 559292:YKL121W
uniprot id: P32330
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
messages: Belongs to the WD repeat DGR2 family.
messages: Increases cellular tolerance to 2-deoxy-glucose.
messages: Present with 504 molecules/cell in log phase SD medium.

559292:YNL004W
gene id: 559292:YNL004W
uniprot id: P38922
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus (PubMed:14676199, PubMed:14769921, PubMed:24452287). Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded. On correctly spliced mRNAs, GBP2 and HRB1 recruit MEX67 to allow nuclear export. On faulty mRNAs, GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation (PubMed:24452287).
messages: Cytoplasm
messages: Methylated by HMT1.
messages: Nucleus
messages: P-body
messages: Present with 1990 molecules/cell in log phase SD medium.
messages: Stress granule

559292:YPL048W
gene id: 559292:YPL048W
uniprot id: P29547
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Nucleus
messages: Present with 60865 molecules/cell in log phase SD medium.
messages: Subunit of the eukaryotic elongation factor 1 complex (eEF1). Probably plays a role in anchoring the complex to other cellular components. May be involved in transcriptional regulation of MXR1.
messages: The eukaryotic elongation factor 1 complex (eEF1) is probably a heterohexamer. Two trimeric complexes, each composed of eEF1A (TEF1 or TEF2), eEF1Balpha (EFB1) and eEF1Bgamma (CAM1 or TEF4), are probably dimerized via the eF1Bgamma subunits. The eEF1B subcomplex with the GEF activity is formed of eEF1Balpha and eEF1Bgamma. CAM1 interacts with EFB1. Component of a complex bound to MXR1 promoter region.
messages: There are 2 isoforms for eEF1Bgamma in yeast.
messages: Ths GST-like domain mediates the interaction to eEFB1 and may be responsible for dimerization of the eEF1 complex.

559292:YOR208W
gene id: 559292:YOR208W
uniprot id: P29461
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Cytoplasm
messages: Interacts with HOG1.
messages: Major phosphatase responsible with PTP3 for tyrosine dephosphorylation of MAP kinase HOG1 to inactivate its activity. May also be involved in the regulation of MAP kinase FUS3. May be implicated in the ubiquitin-mediated protein degradation.
messages: Nucleus
messages: Present with 149 molecules/cell in log phase SD medium.

559292:YDR482C
gene id: 559292:YDR482C
uniprot id: Q03375
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the NTC complex (or PRP19-associated complex), composed of at least CEF1, CLF1, ISY1, NTC20, SNT309, SYF1, SYF2, and PRP19. The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex (or CEF1-associated complex) reminiscent of a late-stage spliceosome composed also of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, LEA1, MSL1, PRP8, PRP9, PRP11, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNU114, SPP2, RSE1 and YJU2. Interacts directly with PRP8 (via SCwid domain). Interacts directly with SNU114 (via C-terminus).
messages: Belongs to the CWC21 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome, together with ISY1. May do so by stabilizing the catalytic center or the position of the RNA substrate.
messages: Nucleus
messages: Present with 556 molecules/cell in log phase SD medium.

559292:YDR252W
gene id: 559292:YDR252W
uniprot id: P40314
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the nascent polypeptide-associated complex (NAC), which promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane. Also blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. BTT1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
messages: Belongs to the NAC-beta family.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and either EGD1 or BTT1. NAC associates with ribosomes via EGD1 or BTT1.
messages: Present with 1820 molecules/cell in log phase SD medium.

559292:YFR012W
gene id: 559292:YFR012W
uniprot id: P43595
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Leads to lethality in absence of CDC28.
messages: Membrane

559292:YOL011W
gene id: 559292:YOL011W
uniprot id: Q08108
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysophospholipase family.
messages: Cell membrane
messages: Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate (PubMed:10497163). Mainly responsible for the degradation of phosphatidylinositol in vivo (PubMed:15588231).

559292:YCL047C
gene id: 559292:YCL047C
uniprot id: P25576
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic NMN adenylyltransferase family. POF1 subfamily.
messages: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Involved in the salvage pathway for NAD(+) biosynthesis via NMN (PubMed:24759102). Involved in the filamentation pathway. Suppresses the filamentation defect of a KSS1 deletion (PubMed:21460040).
messages: Cytoplasm
messages: Expression is slightly induced in late log phase.
messages: Interacts with KSS1 (PubMed:21460040). Interacts with UBC7 (PubMed:22204397).
messages: Lowers cellular NAD(+) levels and decreases the efficiency of nicotinamide riboside (NR) utilization, resistance to oxidative stress, and NR-induced life span extension (PubMed:24759102). Highly sensitive to heat shock and higher sensitivity to ER stress agents than wild-type cells (PubMed:22204397).
messages: Nucleus
messages: Present with 830 molecules/cell in log phase SD medium.

559292:YDR113C
gene id: 559292:YDR113C
uniprot id: P40316
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Interacts with the caspase-like ESP1, and prevents its protease activity probably by covering its active site. Interacts with CDC20.
messages: Nucleus
messages: Phosphorylated by CDC28. The phosphorylation may be important for ESP1 localization to the nucleus.
messages: Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESP1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESP1.
messages: The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: Ubiquitinated by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation.

559292:YPR023C
gene id: 559292:YPR023C
uniprot id: Q12432
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRG family.
messages: Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus
messages: Present with 1890 molecules/cell in log phase SD medium.

559292:YKR055W
gene id: 559292:YKR055W
uniprot id: Q00246
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Interacts with BEM4.
messages: Plays an important role in cell growth. Required to keep the uninucleated state. May be involved in the organization of the cytoskeleton which affects microtubule functions. Most likely RHO3 and RHO4 of S.cerevisiae regulate partially overlapping but different pathways.

559292:YAL051W
gene id: 559292:YAL051W
uniprot id: P39720
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of PIP2 and OAF1.
messages: Nucleus
messages: Present with 92 molecules/cell in log phase SD medium.
messages: The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. OAF1 acts as the sensor for oleate and inhibits PIP2 activity under non-inducing conditions. Activity is repressed by glucose.
messages: the 9aaTAD motif (residues 1034 to 1042) is a transactivation domain present in a large number of yeast and animal transcription factors.

559292:YDR105C
gene id: 559292:YDR105C
uniprot id: Q12116
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

559292:YIR004W
gene id: 559292:YIR004W
uniprot id: P40564
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Cytoplasm
messages: Interacts with SLN1.
messages: Present with 8970 molecules/cell in log phase SD medium.
messages: Required for peroxisomal protein import which maintains the function of peroxisomes.

559292:YPR154W
gene id: 559292:YPR154W
uniprot id: Q06449
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although this protein promotes prion formation and it has a Asn/Gln-rich prion-like domain, it does not seem to have a prion form by itself.
messages: Belongs to the LSB1 family.
messages: By heat shock. Can thereby reach physiological protein levels high enough to promote prion-formation.
messages: Cytoplasm
messages: Interacts with LAS17, RSP5 and SUP35.
messages: Nucleus
messages: Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress.
messages: Present with 2190 molecules/cell in log phase SD medium.
messages: The PY motif is recognized directly by the WW domains of RSP5.
messages: Ubiquitinated by RSP5. Ubiquitination reduces the protein abundance and its prion-inducing ability.
messages: actin patch

559292:YAL034W-A
gene id: 559292:YAL034W-A
uniprot id: P39731
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.
messages: Belongs to the mis12 family.
messages: Component of the MIND kinetochore complex, which is composed of at least MTW1, NNF1, NSL1 and DSN1.
messages: Present with 2610 molecules/cell in log phase SD medium.
messages: kinetochore
messages: spindle pole

559292:YGR250C
gene id: 559292:YGR250C
uniprot id: P53316
names: Miscellaneous
names: Subunit
messages: Interacts with RBG1.
messages: Present with 1910 molecules/cell in log phase SD medium.

559292:YGR161C-D
gene id: 559292:YGR161C-D
uniprot id: Q12316
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YGR161C-C ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YDR295C
gene id: 559292:YDR295C
uniprot id: Q06629
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HDA2/3 family. HDA2 subfamily.
messages: Heterodimer with HDA3. Component of the HDA1 histone deacetylase complex composed of at least one HDA1 homodimer and one HDA2/HDA3 heterodimer. Interacts with HDA1 and HDA3.
messages: Nucleus
messages: Present with 1500 molecules/cell in log phase SD medium.
messages: Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

559292:YGL174W
gene id: 559292:YGL174W
uniprot id: P46947
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC26 family.
messages: Belongs to the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3 and PML1. May also belong to the CWC complex (or CEF1-associated complex) composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with IST3 and PML1.
messages: Cytoplasm
messages: Nucleus
messages: Required for efficient splicing and pre-mRNA nuclear retention. May also be involved in positioning the proximal bud pole signal.

559292:YMR169C
gene id: 559292:YMR169C
uniprot id: P54114
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: Cytoplasm
messages: Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Involved in pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis.
messages: Expression is under the control of MSN2 and MSN4, and is induced during diauxic shift and osmotic stress.
messages: Present with 172 molecules/cell in log phase SD medium.

559292:YKL145W
gene id: 559292:YKL145W
uniprot id: P33299
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Interacts with UBR1 and CIC1.
messages: Nucleus
messages: Present with 105 molecules/cell in log phase SD medium.
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
messages: The N-terminus is blocked.

559292:YAL023C
gene id: 559292:YAL023C
uniprot id: P31382
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Leads to diminished in vitro and in vivo O-mannosylation activity.
messages: PMT1 and PMT2 form a functional heterodimer. The complex interacts with endoplasmic reticulum proteins EMP24, ERV25, ERP1, ERP2, CDC48, HRD1, USA1, YOS9, ERO1, PDI1, UBR1, Cue4, DFM1 and TED1. Forms also a minor complex with PMT5.
messages: Present with 6510 molecules/cell in log phase SD medium.
messages: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT5 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export.

559292:YIL147C
gene id: 559292:YIL147C
uniprot id: P39928
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Histidine kinase that acts as an osmosensor at the plasma membrane. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, the histidine kinase autophosphorylates His-576. This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1. Under high osmolarity conditions, the histidine kinase is no longer active.
messages: Interacts with DJP1, MOG1 and YPD1.
messages: Present with 656 molecules/cell in log phase SD medium.
messages: The phosphorelay mechanism involves the sequential transfer of a phosphate group from His-576 (H1) in the histidine kinase domain (transmitter domain) to Asp-1144 (D1) of the response regulatory domain (receiver domain). This transfer probably occurs between two SLN1 molecules, rather than intramolecularly. The phosphate group is further transferred to 'His-64' (H2) of YPD1 and finally to 'Asp-554' (D2) of SSK1 or 'Asp-427' (D2) of SKN7.

559292:YER031C
gene id: 559292:YER031C
uniprot id: P38555
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by the guanine nucleotide-exchange factor (GEF) TRAPP complex, and inactivated by GTPase-activating protein (GAP) GYP3.
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Golgi apparatus membrane
messages: Interacts with YIF1, YIP1, YIP3, YIP4 and YIP5. Interacts with TRS130.
messages: Present with 5955 molecules/cell in log phase SD medium.
messages: Required for protein transport in the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Plays a role in autophagy.

559292:YPR174C
gene id: 559292:YPR174C
uniprot id: Q06616
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus membrane
messages: Present with 3420 molecules/cell in log phase SD medium.
messages: Specialized component of the nuclear membrane that may be involved in the connection of the spindle pole body (SPB) to the nuclear envelope.
messages: spindle pole body

559292:YLR011W
gene id: 559292:YLR011W
uniprot id: Q07923
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Has several reductase activities that are NAD(P)H-dependent and involve FMN as a cofactor, ferricyanide being the best substrate for reduction. May be involved in ferric iron assimilation.
messages: Homodimer.
messages: Induced by low temperature and by cycloheximide.
messages: Nucleus
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YMR264W
gene id: 559292:YMR264W
uniprot id: P38428
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CUE1 family.
messages: Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Has also a role in cold adaptation, perhaps through effects on sterol biosynthesis.
messages: Endoplasmic reticulum membrane
messages: Forms a heterodimer with UBC7. Interacts with SSM4/DOA10 and UBX2/SEL1.
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YLR214W
gene id: 559292:YLR214W
uniprot id: P32791
names: Activity Regulation
names: Biotechnology
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Cell membrane
messages: Expression is repressed by the addition of iron (PubMed:1570306, PubMed:1431884). Induced by transcription factor MAC1 upon copper deprivation (PubMed:7814363, PubMed:9153234, PubMed:9726978, PubMed:10341420). Induced by transcription factor AFT1 upon iron deprivation (PubMed:7720713, PubMed:9200812, PubMed:9726978, PubMed:10341420, PubMed:16024809).
messages: Inhibited by nitric oxide (NO).
messages: Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake.
messages: Present with 892 molecules/cell in log phase SD medium.
messages: Responsible for the reduction of the azo bond of azo dyes, making yeasts efficient azo dye decolorizers.

559292:YIR023W
gene id: 559292:YIR023W
uniprot id: P21657
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2), urea (DUR1 and DUR2), arginine and allantoin.
messages: Present with 704 molecules/cell in log phase SD medium.

559292:YBR073W
gene id: 559292:YBR073W
uniprot id: P38086
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Interacts with RAD51 and DMC1.
messages: Involved in the recombinational repair of double-strand breaks (DSB) in DNA during mitosis and meiosis. Has DNA dependent ATPase activity. Promotes D-loop (displacement loop) formation with RAD51 recombinase. Modifies the topology of double-stranded DNA during the D-loop reaction to facilitate the invasion of the homologous duplex molecule by the initiating single-stranded DNA substrate. Required for adaptation from G2/M checkpoint arrest induced by a double strand break, by participating in monitoring the extent of single-stranded DNA produced by resection of DNA ends. This role is distinct from its roles in recombination. Promotes colocalization of RAD51 and DMC1 during meiotic recombination. Involved in crossover interference.
messages: It is uncertain whether Met-1 or Met-35 is the initiator. In many S.cerevisiae strains, it is not possible to extend the sequence at the N-terminus beyond Met-35 because of a frameshift in the upstream sequence when compared to strain S288c. However, experimental evidence indicates that the longer protein is made in S288c.
messages: Nucleus
messages: Present with 1270 molecules/cell in log phase SD medium.

559292:YDR038C
gene id: 559292:YDR038C
uniprot id: Q12691
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.
messages: Cell membrane
messages: Present with 606 molecules/cell in log phase SD medium.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithium ions to allow salt tolerance.

559292:YJL070C
gene id: 559292:YJL070C
uniprot id: P40361
names: Caution
names: Miscellaneous
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Lacks the conserved His residues essential for binding the catalytic zinc ion. Lacks the conserved residues important for substrate binding and catalysis. Its enzyme activity is therefore unsure.
messages: Present with 1100 molecules/cell in log phase SD medium.

559292:YML106W
gene id: 559292:YML106W
uniprot id: P13298
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Present with 39300 molecules/cell in log phase SD medium.
messages: There are two genes coding for OPRT in yeast.

559292:YDR518W
gene id: 559292:YDR518W
uniprot id: P32474
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Interacts with EPS1.
messages: May have O-linked mannose residues.
messages: Probably interacts with nascent polypeptides in the endoplasmic reticulum. It is an essential gene only in the absence of PDI. Its native disulfide isomerase activity is very low.

559292:YOL029C
gene id: 559292:YOL029C
uniprot id: Q08187
names: Subunit
messages: Interacts with the chaperones HSP82 and HSC82.

559292:YDR351W
gene id: 559292:YDR351W
uniprot id: P42223
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: With SBE22, is involved in cell wall integrity and polarity processes like bud growth, through the transport of CHS3 and UTR2 to sites of growth.

559292:YKL089W
gene id: 559292:YKL089W
uniprot id: P35201
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-C/MIF2 family.
messages: Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:22561346). Interacts with CBF1 (PubMed:7579695).
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:8408221, PubMed:7579695, PubMed:22561346).
messages: Nucleus
messages: Present with 465 molecules/cell in log phase SD medium.
messages: centromere
messages: kinetochore

559292:YER180C
gene id: 559292:YER180C
uniprot id: P32645
names: Developmental Stage
names: Function
messages: Expressed 7.5 hours after induction of meiosis.
messages: Indispensable for spore formation.

559292:YKL068W
gene id: 559292:YKL068W
uniprot id: Q02629
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin GLFG family.
messages: Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. Through its FG repeats NUP100 interacts with numerous karyopherins including KAP95, and MEX67.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP100 plays an important role in several nuclear export and import pathways including poly(A)+ RNA and protein transport.
messages: Nucleus membrane
messages: Present with 358 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YOR126C
gene id: 559292:YOR126C
uniprot id: P41734
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Accumulates approximately 19 times higher amounts of isoamyl acetate compared to wild-type in laboratory scale sake brewing.
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Homodimer.
messages: Plays a crucial role in the hydrolysis of isoamyl acetate in sake mash (Ref.2). Hydrolyzes short chain esters from acetate (C2) to hexanoate (C6), showing more specificity for shorter chain exters. No activity for decanoate (C10) esters (PubMed:21069734).

559292:YIL156W-B
gene id: 559292:YIL156W-B
uniprot id: Q2V2P4
names: Subcellular Location Annotation
messages: Vacuole

559292:YJL096W
gene id: 559292:YJL096W
uniprot id: P40858
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion
messages: Present with 1850 molecules/cell in log phase SD medium.

559292:YMR317W
gene id: 559292:YMR317W
uniprot id: Q04893
names: Domain
messages: Contains many Ser/Thr-rich domain and repeats.

559292:YOR297C
gene id: 559292:YOR297C
uniprot id: Q08749
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although cells lacking TIM18 live well and do not display any strong phenotype, they do not survive in the absence of mitochondrial DNA.
messages: Belongs to the CybS family.
messages: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. Its role in the complex is unclear but it may be involved in the assembly and stabilization of the TIM22 complex.
messages: Component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54, associated with the peripheral proteins MRS5/TIM12 and the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).
messages: Mitochondrion inner membrane
messages: Present with 4440 molecules/cell in log phase SD medium.

559292:YLR091W
gene id: 559292:YLR091W
uniprot id: Q12393
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GEP5 family.
messages: Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins.
messages: Mitochondrion

559292:YBR143C
gene id: 559292:YBR143C
uniprot id: P12385
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP. Interacts with TPA1.
messages: N5-methylated on Gln-182 by MTQ2.
messages: Present with 13100 molecules/cell in log phase SD medium.

559292:YDR147W
gene id: 559292:YDR147W
uniprot id: Q03764
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the choline/ethanolamine kinase family.
messages: Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine branch of the Kennedy pathway. Also exhibits choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway, but its preferred substrate is ethanolamine.
messages: Cytoplasm
messages: Induced by zinc-depletion via the transcription factor ZAP1. Expression is sensitive to intracellular zinc levels (PubMed:16551612). Repressed by inositol (PubMed:15201274).
messages: Present with 3420 molecules/cell in log phase SD medium.

559292:YLR426W
gene id: 559292:YLR426W
uniprot id: Q06417
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Involved in the resistance to DNA-damaging agents.
messages: Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.
messages: Mitochondrion membrane
messages: Present with 2130 molecules/cell in log phase SD medium.

559292:YKR020W
gene id: 559292:YKR020W
uniprot id: P36116
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VPS fifty three (VFT) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts with the t-SNARE TLG1.
messages: Endosome membrane
messages: Involved in retrograde transport from early and late endosomes to late Golgi. Links the Golgi-associated retrograde protein (GARP) complex to the t-SNARE TLG1, leading to the fusion between the endosomal vesicles with the late Golgi. May also be indirectly involved in apical bud growth.
messages: Present with 319 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YBR089C-A
gene id: 559292:YBR089C-A
uniprot id: P11633
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NHP6 family.
messages: Chromosome
messages: DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6A.
messages: Nucleus
messages: Present with 4590 molecules/cell in log phase SD medium.
messages: Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT (yFACT or SNP) complex, which is associated with nucleosomes. Multiple molecules of NHP6 (NHP6A and/or NHP6B) are required to recruit the SPT16-POB3 heterodimer to DNA.

559292:YPL065W
gene id: 559292:YPL065W
uniprot id: Q02767
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of STP22, VPS28, SRN2 and MVB12 in a 1:1:1:1 stoichiometry. Self-associates. Interacts with VPS27; the interaction mediates the association with the ESCRT-0 complex. Interacts with VPS20; the interaction mediates the association with the ESCRT-III complex.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for normal endocytic and biosynthetic traffic to the yeast vacuole.
messages: Cytoplasm
messages: Endosome
messages: Late endosome membrane
messages: Present with 1420 molecules/cell in log phase SD medium.

559292:YPR068C
gene id: 559292:YPR068C
uniprot id: Q12214
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Nucleus
messages: Present with 538 molecules/cell in log phase SD medium.
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).

559292:YHR044C
gene id: 559292:YHR044C
uniprot id: P38774
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.
messages: Phosphatase that is active on 2-deoxy-D-glucose 6-phosphate (2-DOG-6P), as well as on fructose-1-P.
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YLL011W
gene id: 559292:YLL011W
uniprot id: P33750
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: Interacts with snoRNA U3. Interacts with NOP1 and MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Present with 6620 molecules/cell in log phase SD medium.
messages: Required for ribosomal RNA processing.
messages: nucleolus

559292:YLR271W
gene id: 559292:YLR271W
uniprot id: Q06152
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 1470 molecules/cell in log phase SD medium.

559292:YEL062W
gene id: 559292:YEL062W
uniprot id: P39923
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NPR2 family.
messages: By urea and proline.
messages: Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1. Forms a heterodimer with NPR3.
messages: Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis (PubMed:21454883). Mediates inactivation of the TORC1 complex in response to amino acid starvation (PubMed:19521502, PubMed:26510498). Post-transcriptional regulator of nitrogen permeases (PubMed:19521502). May be involved in putative NPR1-dependent phosphorylation of nitrogen permeases or in the processing and targeting of nitrogen permeases at the level of the endoplasmic reticulum (PubMed:19521502).
messages: Present with 319 molecules/cell in log phase SD medium.
messages: TORC1 abnormally activated in presence of rapamycin.
messages: Vacuole membrane

559292:YJL222W
gene id: 559292:YJL222W
uniprot id: P40890
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family.
messages: Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.
messages: Present with 279 molecules/cell in log phase SD medium.
messages: trans-Golgi network membrane

559292:YBR053C
gene id: 559292:YBR053C
uniprot id: P38235
names: Miscellaneous
names: Similarity
messages: Belongs to the SMP-30/CGR1 family.
messages: Present with 4190 molecules/cell in log phase SD medium.

559292:YNR002C
gene id: 559292:YNR002C
uniprot id: P32907
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: By external ammonia.
messages: Cell membrane
messages: Transporter protein required for ammonia export. Involved in acetate resistance.

559292:YBR077C
gene id: 559292:YBR077C
uniprot id: P38247
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal activation of TORC1 signaling (PubMed:32801125). Abnormal punctate localization of TOR1 (PubMed:32801125). Sensitive to high hydrostatic pressure (mechanical stress) (PubMed:32801125).
messages: Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1 (PubMed:16732272). Component of the EGO complex, at least composed of GTR2, SLM4 and MEH1 (PubMed:15989961).
messages: Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272). Component of the EGO complex, a complex involved in the regulation of microautophagy (PubMed:15989961).
messages: Present with 3490 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YMR094W
gene id: 559292:YMR094W
uniprot id: P35203
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as central component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters. The association of CBF3C with CBF3D and SGT1 is required for CBF3C activation and CBF3 assembly.
messages: Component of the CBF3 copmplex, which is formed of CBF3A/CBF2, CBF3B/CEP3, CBF3C/CTF13 and CBF3D. CBF3C interacts with CBF3D and SGT1.
messages: Nucleus
messages: centromere

559292:YLL018C-A
gene id: 559292:YLL018C-A
uniprot id: Q3E731
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX19 family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Present with 5750 molecules/cell in log phase SD medium.
messages: Required for the assembly of mitochondrial cytochrome c oxidase.

559292:YDL155W
gene id: 559292:YDL155W
uniprot id: P24870
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
messages: Present with 892 molecules/cell in log phase SD medium.

559292:YGR040W
gene id: 559292:YGR040W
uniprot id: P14681
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by tyrosine and threonine phosphorylation after pheromone treatment or carbon/nitrogen limitation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-183 and Tyr-185 by STE7 in response to pheromone or carbon/nitrogen limitation, which activates the enzyme. Activated FUS3 down-regulates KSS1 phosphorylation.
messages: In the nucleus, KSS1 forms a complex with DIG1, DIG2 and STE12; in contrast to FUS3 the interaction of KSS1 with STE12 does not depend on DIG1 and DIG2. Phosphorylated KSS1 shows reduced interaction with STE12. During pheromone activation and phosphorylation, KSS1 forms a membrane-associated complex with the scaffold protein STE5, the MAPKK STE7, the MAPKKK STE11, and the G-protein beta subunit GBB/STE4; interacting directly with POF1, STE7 and STE5 proteins.
messages: Nucleus
messages: Periplasm
messages: Present with 5480 molecules/cell in log phase SD medium.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
messages: Together with closely related FUS3, KSS1 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively. Phosphorylated KSS1 activates both pathways, whereas activated FUS3 activates the mating but suppresses the filamentation pathway. KSS1 activity is down-regulated by FUS3 during pheromone induction to prevent inappropriate activation of the filamentation pathway. During induction of filamentation, KSS1 activates the transcription factor STE12 resulting in its binding to and activation of filamentation specific genes. Non-activated KSS1 has a kinase-independent repressive effect on STE12 transcriptional activity, that is mediated by direct binding to STE12 and depends on the presence of DIG1 and DIG2, and that is required for the suppression of filamentation under normal growth conditions. SSN3/SRB10 contributes further to the suppression of filamentation under these conditions by reducing STE12 stability independent of KSS1. FUS3 can partially compensate for the lack of KSS1 but filamentation becomes constitutively induced at a low level in the absence of any signal. KSS1 phosphorylates STE7, STE5, FAR1, DIG1, DIG2, STE12, and SST2.

559292:YCL038C
gene id: 559292:YCL038C
uniprot id: P25568
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
messages: Vacuole membrane

559292:YIL115C
gene id: 559292:YIL115C
uniprot id: P40477
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC) (PubMed:17546040). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. Part of the NUP82 subcomplex, interacts with NUP82 through its C-terminal coiled coil (PubMed:9736720, PubMed:17546040, PubMed:23223634, PubMed:25646085). This subcomplex is the base for interactions with NUP116 and GLE2, with NUP42 and GLE1 and with DYN2 (PubMed:17546040, PubMed:23223634). Interacts directly with DYN2 (PubMed:17546040, PubMed:23223634, PubMed:25646085). Interacts through its FG repeats with karyopherins, such as heterodimeric mRNA transport factor MEX67/MTR2, CRM1 (XPO1), and PSE1 (GSP1-GDP dependent). Interaction with CRM1 (XPO1) is GSP1-GTP dependent and stimulated by RNA1. NUP159 also interacts with GLE1 and the ATP-dependent RNA helicase DBP5.
messages: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: SXFG/PXFG repeats are especially abundant in NUPs on the cytoplasmic side.
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP159 plays an important role in several nuclear export pathways including poly(A)+ RNA, pre-ribosome, and protein export.
messages: Nucleus membrane
messages: Present with 1230 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YDL195W
gene id: 559292:YDL195W
uniprot id: P38968
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC31 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Present with 1840 molecules/cell in log phase SD medium.
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13. Interacts with EMP24, ERV25, SEC16 and SHR3.

559292:YPL058C
gene id: 559292:YPL058C
uniprot id: Q02785
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: By weak acids like sorbate through the WAR1 transcription activator.
messages: Cell membrane
messages: Plasma membrane transporter which mediates resistance to water-soluble, monocarboxylic acids with chain lengths of from C1 to C7 by active extrusion of the preservative anions from the cytosol. Also involved in the export of aromatic and branched-chain organic acids produced in amino acid catabolism.
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YJR132W
gene id: 559292:YJR132W
uniprot id: P46970
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Active in protein import into the nucleus. Its major import substrate is transcription elongation factor TFIIS.
messages: Cytoplasm
messages: GTP-bound Ran dissociates the isolated NMD5/TFIIS complex.
messages: Nucleus
messages: Present with 13500 molecules/cell in log phase SD medium.

559292:YBL075C
gene id: 559292:YBL075C
uniprot id: P09435
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Present with 6440 molecules/cell in log phase SD medium.

559292:YCR060W
gene id: 559292:YCR060W
uniprot id: P25638
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1660 molecules/cell in log phase SD medium.

559292:YMR190C
gene id: 559292:YMR190C
uniprot id: P35187
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase able to unwind duplex DNA or DNA- RNA heteroduplex (PubMed:9545297). Displacement of the DNA strand occurs in the 3' to 5' direction with respect to the single-stranded DNA flanking the duplex (PubMed:9545297). Acts as an integral component of the S-phase checkpoint response, which arrests cells due to DNA damage or blocked fork progression during DNA replication (PubMed:10640278). Can create a deleterious topological substrate that TOP3 preferentially resolves. The TOP3-SGS1 protein complex may function as a eukaryotic reverse gyrase introducing positive supercoils into extrachromosomal ribosomal DNA rings (PubMed:7969174). Together with topoisomerase II has a role in chromosomal segregation (PubMed:7736577). Maintains rDNA structure where it has a role in re-starting stalled replication forks (PubMed:12228808).
messages: Belongs to the helicase family. RecQ subfamily.
messages: Expression is regulated through the cell cycle with an accumulation in S phase.
messages: Heterodimer with TOP3 (PubMed:7969174, PubMed:15899853). Forms a complex with TOP3 and RMI1 (PubMed:15889139). Forms a ternary complex with a MLH1-MLH3 heterodimer (MutLbeta) during meiosis (PubMed:12200140). Interacts with TOP2 (PubMed:7736577).
messages: nucleolus

559292:YBR254C
gene id: 559292:YBR254C
uniprot id: P38334
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.
messages: Preautophagosomal structure
messages: Present with 1200 molecules/cell in log phase SD medium.
messages: cis-Golgi network

559292:YDR456W
gene id: 559292:YDR456W
uniprot id: Q04121
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosomal/prevacuolar electroneutral Na(+)/H(+) exchanger which mediates intracellular sequestration of Na(+) cations, regulates vacuolar pH and contributes to osmotolerance following sudden exposure to hyperosmotic media. Contributes also to the postdiauxic/stationary phase resistance to osmotic stress and allows for the continued growth of cells until the acquired osmotolerance response can occur. Involved in hygromycin resistance probably through its influence on the electrochemical proton gradient affecting secondarily the entrance of hygromycin. Mediates pH-dependent vesicle trafficking out of the endosome. Contributes to K(+) sequestration and homeostasis.
messages: Endosome membrane
messages: Interacts with CYP6.
messages: Numerous studies suggest that the C-terminal tail of the Na(+)/H(+) exchangers assumes a cytosolic orientation and constitutes a regulatory region. This cytosolic localization is confirmed by phosphorylation analysis (PubMed:15665377 and PubMed:18407956). However, residues Asn-515, Asn-550 and Asn-563 have been shown to be glycosylated and localized at the lumenal side (PubMed:11036065). These contradictory results suggest an unusual topology of the C-terminal tail which may contain membrane spans formed by beta-sheets or even may switch from one side to the other of the membrane.
messages: Present with 521 molecules/cell in log phase SD medium.
messages: Prevacuolar compartment membrane

559292:YGL151W
gene id: 559292:YGL151W
uniprot id: P53114
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 5 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins.
messages: Nucleus
messages: Present with 2491 molecules/cell in log phase SD medium.

559292:YNL195C
gene id: 559292:YNL195C
uniprot id: P40168
names: Subcellular Location Annotation
messages: Mitochondrion

559292:YDR170C
gene id: 559292:YDR170C
uniprot id: P11075
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus
messages: May play a role in vesicular budding and traffic between compartments of the Golgi apparatus.
messages: Present with 3670 molecules/cell in log phase SD medium.
messages: The highly charged acidic domain may serve a structural role to interact with lipids or proteins on the cytoplasmic surface of the Golgi apparatus.

559292:YNL280C
gene id: 559292:YNL280C
uniprot id: P32462
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Delta(14)-sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1418625, PubMed:8125337). ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol (PubMed:1418625, PubMed:8125337). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27…
messages: Inhibited by the morpholine antifungal drug fenpropimorph.
messages: Leads to the accumulation of ergosta-8,14-dienol as the major sterol.
messages: Membrane
messages: Present with 1600 molecules/cell in log phase SD medium.

559292:YOR304C-A
gene id: 559292:YOR304C-A
uniprot id: O14468
names: Miscellaneous
names: Subcellular Location Annotation
messages: Bud
messages: Bud neck
messages: Cytoplasm
messages: Present with 656 molecules/cell in log phase SD medium.

559292:YLR245C
gene id: 559292:YLR245C
uniprot id: Q06549
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Homodimer.
messages: Present with 3120 molecules/cell in log phase SD medium.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

559292:YMR064W
gene id: 559292:YMR064W
uniprot id: P32493
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AEP1 family.
messages: Mitochondrion
messages: Present with 504 molecules/cell in log phase SD medium.
messages: Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase.

559292:YMR139W
gene id: 559292:YMR139W
uniprot id: P38615
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Interacts with TDA1.
messages: Present with 6990 molecules/cell in log phase SD medium.
messages: Serine/threonine protein kinase that is thought to function in regulating kinetochore activity and entry into meiosis. Could phosphorylate IME1.

559292:YNL147W
gene id: 559292:YNL147W
uniprot id: P53905
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, spliceosomal U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM7 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. LSM7, probably in a complex that contains LSM2-LSM7 but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a doughnut shape. The LSm subunits are arranged in the order LSM1, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. Except for LSM1, where a C-terminal helix crosses the ring structure to form additional interactions with LSM3 and LSM6, each subunit interacts only with its two neighboring subunits. The LSM1-LSM7 complex interacts with PAT1; within the complex PAT1 has direct interactions with LSM2 and LSM3. Component of the heptameric LSM2-LSM8 complex that forms a seven-membered ring structure with a doughnut shape; an RNA strand can pass through the hole in the center of the ring structure. The LSm subunits are arranged in the order LSM8, LSM2, LSM3, LSM6, LSM5, LSM7 and LSM4. LSM2-LSM8 associates with PAT1 and XRN1. A complex comprising LSM2-LSM7 without LSM1 or LSM8 may exist. Component of the spliceosome U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Cytoplasm
messages: Nucleus
messages: Present with 3070 molecules/cell in log phase SD medium.

559292:YEL048C
gene id: 559292:YEL048C
uniprot id: P32613
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Interacts with the TRAPP II complex; TRAPP II subunits TRS33 and TRS65 are required for this interaction.
messages: Present with 8660 molecules/cell in log phase SD medium.
messages: Required, together with the TRAPP II subunit TRS33, for TRAPP II complex assembly or stability, and for proper Golgi localization of TRAPP and the Rab GTPase YPT31.
messages: trans-Golgi network

559292:YMR011W
gene id: 559292:YMR011W
uniprot id: P23585
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.
messages: High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters.
messages: Membrane
messages: Repressed at high glucose concentrations.

559292:YPR096C
gene id: 559292:YPR096C
uniprot id: O13587
names: Subunit
messages: May interact with ribosomes.

559292:YNL080C
gene id: 559292:YNL080C
uniprot id: P53938
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EOS1 family.
messages: Endoplasmic reticulum membrane
messages: Involved in oxidative stress resistance and N-glycosylation.
messages: N-glycosylated.
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YCL001W-B
gene id: 559292:YCL001W-B
uniprot id: Q96VH2
names: Similarity
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily. Highly divergent.

559292:YCR065W
gene id: 559292:YCR065W
uniprot id: P25364
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by CDK1.
messages: Present with 358 molecules/cell in log phase SD medium.
messages: Transcription factor regulating the cell cycle specific transcription of a spindle pole body (SPB) calmodulin binding protein SPC110. Required for full induction of SPC110 transcription in late G1. Binds to DNA consensus sequence 5'-[AT]AA[TC]AAACAA[AT]-3'. Dosage dependent suppressor of calmodulin mutants which have specific defects in SPB assembly.

559292:YCL058C
gene id: 559292:YCL058C
uniprot id: P25585
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Involved in maintaining an adequate ionic strength homeostasis of the cellular aqueous environment, necessary for normal growth rate. Required for survival upon exposure to K1 killer toxin and hence plays a role in cell wall glucan synthesis. Required for dithiothreitol (DTT) resistance. Involved in cell cycle progression.
messages: cell wall

559292:YML114C
gene id: 559292:YML114C
uniprot id: Q03750
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF8 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: In TFIID, TAF8 heterodimerizes with TAF10. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.
messages: Nucleus
messages: Present with 4684 (+/-522) molecules/cell in log phase SD medium.

559292:YGR233C
gene id: 559292:YGR233C
uniprot id: P17442
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Associates specifically with the PHO80-PHO85 and PCL7-PHO85 cyclin-CDK complexes, and much of this interaction is mediated through the PHO80 and PCL7 cyclin subunits. Interacts with the transcription factor PHO4.
messages: Cytoplasm
messages: Inhibits the kinase activity of the cyclin-CDKs PHO80-PHO85 and PCL7-PHO85 under low-phosphate conditions.
messages: Nucleus
messages: Phosphorylated by the cyclin-CDK PHO80-PHO85. Phosphorylation mediates the formation of a stable interaction with the cyclin-CDK and is required for function as an active inhibitor of the complex under phosphate starvation conditions.
messages: Present with 2930 molecules/cell in log phase SD medium.

559292:YER087C-B
gene id: 559292:YER087C-B
uniprot id: P52870
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Component of the heterotrimeric Sec61 complex, which is composed of SSH1, SBH1 and SSS1. Presumably three to four Sec61 heterotrimers assemble into an oligomeric ring with a central aqueous pore. In cotranslational ER import, the pore diameter varies from 9-15 A in a ribosome-free resting state to 40-60 A in a functional state when associated with the ribosome. The Sec61 complex is part of a channel-forming translocon complex whose composition seem to change dependent upon different functional states. During post-translational ER import the Sec61 complex associates with the Sec62/63 complex to form the Sec complex. SBH1 interacts OST2, OST4 and WBP1 components of the OT complex.
messages: Endoplasmic reticulum membrane
messages: Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2.

559292:YOR094W
gene id: 559292:YOR094W
uniprot id: P40994
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus
messages: Interacts with RUD3.
messages: Present with 1240 molecules/cell in log phase SD medium.

559292:YER024W
gene id: 559292:YER024W
uniprot id: P40017
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Carnitine O-acetyltransferase involved in the shutteling of acetyl-CoA in the cell.
messages: Cytoplasm
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YNL304W
gene id: 559292:YNL304W
uniprot id: P48559
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Bud neck
messages: Bud tip
messages: Endoplasmic reticulum membrane
messages: Interacts with MYO2 (via C-terminal tail domain). Interacts with YIF1, YIP3, YIP4 and YIP5.
messages: Involved in the positive control of both endoplasmic reticulum (ER) and mitochondrion inheritance during cell divison. Required for the MYO2-dependent retention of newly inherited mitochondria at the bud tip in developing daughter cells.
messages: Present with 2850 molecules/cell in log phase SD medium.

559292:YIL035C
gene id: 559292:YIL035C
uniprot id: P15790
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Phosphorylates YTA7 during S-phase to promote transcription of histones (PubMed:22156209).
messages: Present with 7180 molecules/cell in log phase SD medium.
messages: Tetramer composed of an alpha chain, an alpha', one beta chain and one beta' chain (PubMed:12242279). Interacts with FACT subunits POB3 and SPT16 (PubMed:12242279). Interacts with YTA7 (PubMed:22156209).

559292:YIL027C
gene id: 559292:YIL027C
uniprot id: P40540
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
messages: Present with 5240 molecules/cell in log phase SD medium.

559292:YCR059C
gene id: 559292:YCR059C
uniprot id: P25637
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPACT family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with GCN1 (via C-terminus); this interaction reduces the GCN1-GCN20 complex formation and prevents the interaction of GCN1 with GCN2 protein kinase and GCN2 activation in amino acid-starved cells (PubMed:15126500, PubMed:21239490). Interacts (via C-terminus) with ACT1; this interaction occurs in a GCN1-independent manner (PubMed:15126500, PubMed:21239490). Interacts with RPL39; this interaction occurs in a GCN1-independent manner (PubMed:22404850). Associates (via middle region) with ribosomes; this association occurs in a GCN1-independent manner and persists under amino acid starvation conditions (PubMed:22404850).
messages: Nucleus
messages: Present with 3030 molecules/cell in log phase SD medium.
messages: Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis (PubMed:15126500, PubMed:15937339, PubMed:24333428). In normal conditions, it resides in a actin complex and has no activity (PubMed:15126500).

559292:YDR141C
gene id: 559292:YDR141C
uniprot id: Q03921
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dopey family.
messages: Golgi apparatus membrane
messages: Interacts with MON2.
messages: Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum.
messages: Present with 2700 molecules/cell in log phase SD medium.

559292:YKR076W
gene id: 559292:YKR076W
uniprot id: P36156
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: A version of this protein truncated after amino acid 200 is not active in the beta-hydroxyethyl disulfide (HED) assay.
messages: Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.
messages: Belongs to the GST superfamily. Omega family.
messages: Cytoplasm
messages: Present with 1670 molecules/cell in log phase SD medium.
messages: Under oxidative stress conditions. By agents such as diamide, 1-chloro-2,4-dinitrobenzene, tert-butyl hydroperoxide (t-BOOH) and cadmium in a transcriptional factors YAP1 and/or MSN2/4-dependent manner.

559292:YPR049C
gene id: 559292:YPR049C
uniprot id: Q12527
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by the NuA4 histone acetyltransferase (HAT) complex.
messages: Belongs to the ATG11 family.
messages: Homodimer and potential homooligomers. Interacts with ATG1 kinase and the ATG19 and ATG34 cargo protein transporters. Interacts with ATG9, ATG17, ATG20, ATG30, ATG32, ATG36 and YPT1.
messages: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for ATG9 anterograde transport from the mitochondria to the PAS. Recruits also the ATG19-prAPE1 complex to the PAS. Required for the Cvt vesicles completion. Plays a significant role in life span extension.
messages: Preautophagosomal structure membrane
messages: Present with 86 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YPR031W
gene id: 559292:YPR031W
uniprot id: Q12311
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NuA3 complex, which consists of at least NTO1, SAS3, TAF14, YNG1 and EAF6.
messages: Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.
messages: Cytoplasm
messages: Nucleus
messages: Present with 172 molecules/cell in log phase SD medium.
messages: Residues 156 to 543 compose a region conserved in chromatin associated proteins.

559292:YLR057W
gene id: 559292:YLR057W
uniprot id: Q12205
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 47 family.
messages: Endoplasmic reticulum membrane
messages: Present with 71 molecules/cell in log phase SD medium.
messages: Putative mannosidase involved in glycoprotein quality control since it is involved in the targeting of misfolded glycoproteins for ER-associated protein degradation (ERAD).

559292:YML022W
gene id: 559292:YML022W
uniprot id: P49435
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Present with 11200 molecules/cell in log phase SD medium.

559292:YPL115C
gene id: 559292:YPL115C
uniprot id: P32873
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase.
messages: Present with 752 molecules/cell in log phase SD medium.

559292:YMR247C
gene id: 559292:YMR247C
uniprot id: Q04781
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase RKR1/LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors associated with the 60S ribosomal subunits (PubMed:23178123, PubMed:23479637, PubMed:25349383).
messages: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:20835226, PubMed:23825054, PubMed:24261871). May indirectly play a role in chromatin function and transcription (PubMed:17283062).
messages: Nucleus
messages: Present with 222 molecules/cell in log phase SD medium.
messages: cytosol

559292:YOR186W
gene id: 559292:YOR186W
uniprot id: Q08560
names: Subcellular Location Annotation
messages: Membrane

559292:YLR223C
gene id: 559292:YLR223C
uniprot id: P39520
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFH1 family.
messages: Controls the pre-rRNA processing machinery in conjunction with FHL1. Could convert FHL1 from a repressor to an activator.
messages: Nucleus
messages: Present with 1430 molecules/cell in log phase SD medium.

559292:YKL078W
gene id: 559292:YKL078W
uniprot id: P36009
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Interacts with NOP19 (PubMed:21941128). Interacts with UBP10 (PubMed:22902402, PubMed:26149687).
messages: Present with 721 molecules/cell in log phase SD medium.
messages: Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis.
messages: nucleolus

559292:YOL007C
gene id: 559292:YOL007C
uniprot id: Q08054
names: Function
messages: Appears to be a structural component of the chitin synthase 3 complex.

559292:YKR101W
gene id: 559292:YKR101W
uniprot id: P21691
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts (via OIR domain) with ORC1 (via BAH domain). Interacts with SIR4. Interacts with CAC1.
messages: Involved in the establishment, but not the maintenance, of heterochromatic silencing at the cryptic mating-type loci HMR and HML. Is recruited by interacting with the ORC1 subunit of the origin recognition complex (ORC), which binds to HML-I or HMR-E silencers, DNA elements that direct the formation of silent chromatin at the mating-type loci. Establishes transcriptional silencing by recruiting the three other SIR proteins, SIR2, SIR3, and SIR4, that function directly in silenced chromatin and establish repression. Also found in centromeric chromatin. Binds to and helps retain CAC1, a subunit of chromatin assembly factor I (CAF-I) at centromeric loci independent on the other SIR proteins.
messages: Nucleus
messages: centromere

559292:YDR233C
gene id: 559292:YDR233C
uniprot id: Q04947
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with POM33.
messages: Present with 37105 molecules/cell in log phase SD medium.

559292:YBL050W
gene id: 559292:YBL050W
uniprot id: P32602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP family.
messages: Binds to vacuolar cis-SNARE complexes composed of the v-SNAREs NYV1, VTI1 and YKT6, and the t-SNAREs VAM3 and VAM7. Interacts with SEC18.
messages: Membrane
messages: SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion.

559292:YPL204W
gene id: 559292:YPL204W
uniprot id: P29295
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Cytoplasm
messages: Interacts with HRI1 (PubMed:21460040). Interacts with ELP1/IKI3; the interaction leads to ELP1/IKI3 phosphorylation (PubMed:21460040).
messages: Present with 10300 molecules/cell in log phase SD medium.
messages: Protein kinase which phosphorylates serine and threonine residues (PubMed:1495994). Can use casein as a substrate (PubMed:1495994). Phosphorylates elongator complex member ELP1/IKI3 on 'Ser-1198' and 'Ser-1202' which promotes the tRNA modification function of the complex (PubMed:25569479). Associated with repair of damaged DNA and meiosis (PubMed:1887218).
messages: nucleolus
messages: nucleoplasm

559292:YLR054C
gene id: 559292:YLR054C
uniprot id: Q12202
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in a late step of spore wall assembly.
messages: Prospore membrane

559292:YLR462W
gene id: 559292:YLR462W
uniprot id: O13556
names: Caution
names: Similarity
messages: Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.
messages: Could be the product of a pseudogene. Although strongly related to DNA helicases, it lacks the helicase domains, suggesting that it has no helicase activity.

559292:YGL179C
gene id: 559292:YGL179C
uniprot id: P43637
names: Domain
names: Function
names: PTM
names: Similarity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: One of the three SNF1 protein kinases (with SAK1 and ELM1) which are required for growth on nonfermentable carbon sources and nonpreferred sugars and for response to environmental stress. Activates SNF1 by phosphorylation of its activation-loop 'Thr-210'. Required for the regulation by SNF1 of the transcription of a large set of genes, the modification the activity of metabolic enzymes, and the control of various nutrient-responsive cellular developmental processes. Phosphorylates also GAL83, MIG1 and SIP2.
messages: The C-terminus (residues 351 to 560) is required for efficient SNF1 pathway signaling.

559292:YOR242C
gene id: 559292:YOR242C
uniprot id: Q08646
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Essential for sporulation and seems to have a role at the time of, or after, initiation of nuclear division. Appears to have a role in outer spore wall formation.
messages: Present with 3000 molecules/cell in log phase SD medium.
messages: Spore wall

559292:YER084W
gene id: 559292:YER084W
uniprot id: P40057
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Present with 300 molecules/cell in log phase SD medium.

559292:YBL021C
gene id: 559292:YBL021C
uniprot id: P13434
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'.
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the CCAT-binding factor (CBF or HAP complex II), which consists of one copy each of HAP2, HAP3, HAP4 and HAP5. The assembly of the HAP2-HAP3-HAP5 heteromer (HAP complex I) occurs in a one-step pathway and its binding to DNA is a prerequisite for the association of HAP4.
messages: Nucleus
messages: Present with 2510 molecules/cell in log phase SD medium.

559292:YOR100C
gene id: 559292:YOR100C
uniprot id: Q12289
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines.

559292:YKR018C
gene id: 559292:YKR018C
uniprot id: P36114
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IML2 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 1770 molecules/cell in log phase SD medium.

559292:YKL138C-A
gene id: 559292:YKL138C-A
uniprot id: P69852
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex HSK3 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle

559292:YBR233W-A
gene id: 559292:YBR233W-A
uniprot id: P69850
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD3 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: Present with 468 molecules/cell in log phase SD medium.
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle

559292:YJL092W
gene id: 559292:YJL092W
uniprot id: P12954
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. The polarity of the helicase activity was determined to be 3' to 5'.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Nucleus
messages: Present with 5190 molecules/cell in log phase SD medium.

559292:YKR062W
gene id: 559292:YKR062W
uniprot id: P36145
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Present with 1150 molecules/cell in log phase SD medium.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
messages: TFIIE is a tetramer of two alpha (TFA1) and two beta (TFA2) subunits.

559292:YKL032C
gene id: 559292:YKL032C
uniprot id: P33417
names: Function
names: Subcellular Location Annotation
messages: Binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Activate the expression of the COX5B gene.
messages: Nucleus

559292:YLR137W
gene id: 559292:YLR137W
uniprot id: Q12367
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RKM5 family.
messages: Present with 468 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L1 (RPL1A and RPL1B) at 'Lys-46'.

559292:YBL076C
gene id: 559292:YBL076C
uniprot id: P09436
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Present with 23300 molecules/cell in log phase SD medium.

559292:YKL143W
gene id: 559292:YKL143W
uniprot id: P34078
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-40S ribosomal subunit. Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Interacts directly with GTR1. Interacts with CRM1.
messages: Belongs to the LTV1 family.
messages: Cytoplasm
messages: Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome.
messages: Nucleus
messages: Phosphorylated, leading to its dissociation from the 40S pre-40S ribosome.
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YJR133W
gene id: 559292:YJR133W
uniprot id: P47165
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May act as a xanthine phosphoribosyltransferase involved in the synthesis of purine nucleotides. Such activity is however unclear in vivo.
messages: Present with 721 molecules/cell in log phase SD medium.

559292:YBR054W
gene id: 559292:YBR054W
uniprot id: P38079
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane
messages: Present with 1950 molecules/cell in log phase SD medium.

559292:YBR078W
gene id: 559292:YBR078W
uniprot id: P38248
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Extensively N-glycosylated.
messages: Present with 6500 wall-bound molecules/cell in log phase YPD medium.
messages: Required for proper cell wall integrity and for the correct assembly of the mannoprotein outer layer of the cell wall. Important for apical bud growth.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

559292:YLL052C
gene id: 559292:YLL052C
uniprot id: P0CD90
names: Caution
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: During exponential phase in rich medium and repressed in minimum medium, hyper-osmolar medium or in sporulating conditions.
messages: Endoplasmic reticulum membrane
messages: This is a truncated version of aquaporin-2. In strain S288c and many laboratory strains, a natural 11 bp deletion in position 109 leads to a frameshift, which disrupts the gene coding for this protein and produces two ORFs YLL052C and YLL053C. A contiguous sequence for aquaporin-2 can be found in strain Sigma 1278B (AC P0CD89).
messages: Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains.

559292:YBL091C-A
gene id: 559292:YBL091C-A
uniprot id: Q6Q595
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Membrane
messages: Present with 358 molecules/cell in log phase SD medium.
messages: Targets proteins containing a FFAT motif to membranes (By similarity). Involved in regulation of phospholipid metabolism.
messages: The MSP domain is required for binding to the FFAT motif of target proteins.

559292:YDL171C
gene id: 559292:YDL171C
uniprot id: Q12680
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.
messages: Homotrimer.
messages: Inhibited by homocysteine sulfonamide.
messages: Present with 18900 molecules/cell in log phase SD medium.

559292:YDR320C-A
gene id: 559292:YDR320C-A
uniprot id: P69851
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD4 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
messages: Nucleus
messages: Present with 967 molecules/cell in log phase SD medium.
messages: The DASH complex is an approximately 210 kDa heterodecamer, which consists of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with an apparent stoichiometry of one copy of each subunit. DASH oligomerizes into a 50 nm ring composed of about 16 molecules that encircles the microtubule. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase IPL1.
messages: kinetochore
messages: spindle

559292:YER019C-A
gene id: 559292:YER019C-A
uniprot id: P52871
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.
messages: Endoplasmic reticulum membrane
messages: Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.
messages: Present with 414 molecules/cell in log phase SD medium.

559292:YLR320W
gene id: 559292:YLR320W
uniprot id: Q06164
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMS22 family.
messages: Component of a cullin-RING ligase (CRL) composed of 4 subunits: the RING protein HRT1, the cullin RTT101, a linker protein MMS1, and the substrate receptor MMS22. This complex further interacts with RTT107 and CTF4 to form RTT101-MMS1-MMS22-RTT107 and RTT101-MMS1-MMS22-CTF4 complexes respectively. Interacts (via C-ter) with MMS1 (via N-ter). Interacts with RTT107.
messages: Nucleus
messages: Substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-MMS22). RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition.

559292:YMR143W
gene id: 559292:YMR143W
uniprot id: P0CX51
uniprot id: P0CX52
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Cytoplasm
messages: Present with 33800 molecules/cell in log phase SD medium.
messages: There are 2 genes for uS9 in yeast.

559292:YCR098C
gene id: 559292:YCR098C
uniprot id: P25346
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Both inositol and phosphate regulate GIT1 transcription and expression is positively regulated by the transcription factor PHO4 (PubMed:12912892).
messages: Cell membrane
messages: Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate (PubMed:9691030, PubMed:12912892, PubMed:16141200).
messages: Impairs the uptake of glycerophosphoinositol (GroPIns) (PubMed:9691030). Impairs also the uptake of glycerophosphocholine (GroPCho) (PubMed:9691030).

559292:YML109W
gene id: 559292:YML109W
uniprot id: P54786
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: 'ZDS' means 'zillion different screens' as both ZDS1 and ZDS2 have been found by a wide variety of genetic screens.
messages: Acts as a negative regulator of polarized growth via an alternative mechanism to ZDS1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways.
messages: Interacts with SKG6.
messages: Present with 105 molecules/cell in log phase SD medium.
messages: To yeast ZDS1/NRC1/CES1.

559292:YDR536W
gene id: 559292:YDR536W
uniprot id: P39932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

559292:YKR095W
gene id: 559292:YKR095W
uniprot id: Q02455
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (NPC) (PubMed:24152732). NPC constitutes the exclusive means of nucleocytoplasmic transport (PubMed:24152732). NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope (PubMed:24152732). Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof (PubMed:24152732). Interacts with NAB2, a hnRNP required for mRNA export (PubMed:12531921). Interacts with MLP2 (PubMed:16027220).
messages: May be phosphorylated by CDC28.
messages: Nucleus
messages: Present with 2710 molecules/cell in log phase SD medium.
messages: PubMed:8154186 misquoted the gene name as 'MPL1'.
messages: Together with the closely related MLP2, involved in the structural and functional organization of perinuclear chromatin (PubMed:10638763). Together with MLP2, associates with the nuclear pore complex and form filamentous structures along the nuclear periphery (PubMed:10085285, PubMed:24152732). Has a role in the localization of Esc1 to nucleolar regions (PubMed:24152732). Together with MLP2, mediates tethering of the some telomeres to the nuclear periphery, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing (PubMed:11862215). MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring (PubMed:12490156). Recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself (PubMed:12490156, PubMed:12531921, PubMed:14718167).
messages: nuclear pore complex

559292:YOR051C
gene id: 559292:YOR051C
uniprot id: Q08421
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETT1 family.
messages: Interacts with STM1.
messages: Nucleus
messages: Present with 10800 molecules/cell in log phase SD medium.
messages: Required for correct translation termination and probably involved in regulation of hypoxic gene expression in association TPA1. Inhibits replication of Brome mosaic virus.

559292:YLR356W
gene id: 559292:YLR356W
uniprot id: Q06485
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG33 family.
messages: Involved in the selective degradation of mitochondria via autophagy during starvation and at post-log phase.
messages: Mitochondrion membrane

559292:YEL054C
gene id: 559292:YEL054C
uniprot id: P0CX53
uniprot id: P0CX54
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: It appears that the main modified species for L12 contains 6 methyl groups, 2 on Pro-2, 3 on Lys-4 and 1 on Arg-67. Although not reproduced with a second method, methylation at Lys-11 cannot be ruled out.
messages: Present with 50300 molecules/cell in log phase SD medium.
messages: Present with 68500 molecules/cell in log phase SD medium.
messages: There are 2 genes for uL11 in yeast.

559292:YGL245W
gene id: 559292:YGL245W
uniprot id: P46655
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). In mitochondria, constitutes the nondiscriminating glutamyl-tRNA synthase that generates the mitochondrial mischarged glutamyl-tRNA(Gln) substrate for the tRNA-dependent amidotransferase (AdT), which generates mitochondrial glutaminyl-tRNA(Gln) by transamidation of glutamyl-tRNA(Gln).
messages: Component of a yeast aminoacyl-tRNA synthase (aaRS) complex formed by methionyl-tRNA synthase MES1, glutamyl-tRNA synthase GUS1 and the tRNA aminoacylation cofactor ARC1 in a stoichiometric complex. Interacts (via N-ter) with ARC1 (via N-ter). Can also form a stable binary complex with ARC1 that is functional in terms of aminoacylation. ARC1 increases the affinity for cognate tRNAs due to the presence of a tRNA binding domain in the middle and C-terminal part of ARC1.
messages: Cytoplasm
messages: Mitochondrion
messages: Present with 48700 molecules/cell in log phase SD medium.

559292:YLR275W
gene id: 559292:YLR275W
uniprot id: Q06217
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Component of the Sm core complex, present in spliceosomal snRNP U1, U2, U4/U6 and U5. The core complex contains SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively), and is probably a heptameric ring structure. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: Present with 799 molecules/cell in log phase SD medium.
messages: cytosol

559292:YOR091W
gene id: 559292:YOR091W
uniprot id: Q12000
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZC3H15/TMA46 family.
messages: Cytoplasm
messages: Interacts with RBG1 and with translating ribosomes.
messages: Present with 4220 molecules/cell in log phase SD medium.

559292:YNL127W
gene id: 559292:YNL127W
uniprot id: P53917
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the FAR11 family.
messages: Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
messages: Participates in the control of the reentry into the cell cycle following pheromone treatment.
messages: Present with 1080 molecules/cell in log phase SD medium.

559292:YOL002C
gene id: 559292:YOL002C
uniprot id: Q12442
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane
messages: Probable receptor, which is involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation.
messages: Regulated by OAF1 and PIP2. Highly expressed in presence of glucose. Expressed at lower level in presence of glycerol or glycerol and oleate. Highly expressed in the presence of saturated fatty-acids such as myristate.

559292:YLR456W
gene id: 559292:YLR456W
uniprot id: Q06199
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Present with 589 molecules/cell in log phase SD medium.

559292:YDR419W
gene id: 559292:YDR419W
uniprot id: Q04049
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: By UV radiation and heat shock. The mRNA is stabilized during stationary phase.
messages: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts.
messages: Interacts with POL30. This interaction is essential for the polymerase eta function.
messages: Nucleus
messages: Present with 1860 molecules/cell in log phase SD medium.

559292:YAL067W-A
gene id: 559292:YAL067W-A
uniprot id: Q8TGK6
names: Similarity
messages: Belongs to the UPF0377 family.

559292:YDL013W
gene id: 559292:YDL013W
uniprot id: P32828
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:18032921, PubMed:17669696, PubMed:17848550, PubMed:18499666, PubMed:18948542, PubMed:31015336). The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921). The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795). The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440). The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737). During replication, the complex helps prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698). The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332). It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921). Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci (PubMed:18086879). Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336)…
messages: Component of the heterodimeric SUMO-targeted ubiquitin ligase (STUbL) complex composed of SLX5 and SLX8 (PubMed:11139495, PubMed:18032921, PubMed:17669696, PubMed:17848550, PubMed:18948542). Interacts with sirtuin SIR2 (PubMed:18086879). Interacts with KAR9 (PubMed:26906737). Interacts with EUC1 (PubMed:31015336).
messages: Leads to severe mitotic defects that include aneuploidy, spindle mispositioning, fish hooks and aberrant spindle kinetics.
messages: Nucleus
messages: The region between Ser-201 and Leu-335 is required recruitment of SLX5 to ub-hotspots via interacion with EUC1.
messages: centromere
messages: kinetochore

559292:YDR365W-A
gene id: 559292:YDR365W-A
uniprot id: P0CX70
uniprot id: P0CX71
uniprot id: P0CX72
uniprot id: P0CX73
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Homotrimer.
messages: Produced by conventional translation.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: Ty1-DR6 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-ER1 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-LR2 is a weakly expressed element. Induced under amino acid starvation conditions by GCN4.
messages: Ty1-PL is a highly expressed element. Induced under amino acid starvation conditions by GCN4.

559292:YBR118W
gene id: 559292:YBR118W
uniprot id: P02994
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: GTP-binding component of the eukaryotic elongation factor 1 complex (eEF1). In its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled by its guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) before binding another molecule of aminoacyl-tRNA. Required for nuclear export of aminoacyl-tRNAs. May also be involved in translational quality control by targeting cotranslationally damaged proteins to the proteasome. Also exhibits actin filament-binding and -bundling activities and is involved in cytoskeleton organization. Plays a role as a negative regulator of GCN2 kinase activity by inhibiting GCN2-mediated eIF-2-alpha phosphorylation in amino acid-repleted cells (PubMed:21849502).
messages: Present with 827 molecules/cell in log phase SD medium.
messages: S-thiolated in response to oxidative stress, probably inhibiting the protein and causing a reduction in protein synthesis.
messages: The eukaryotic elongation factor 1 complex (eEF1) is probably a heterohexamer. Two trimeric complexes, each composed of eEF1A (TEF1 or TEF2), eEF1Balpha (EFB1) and eEF1Bgamma (CAM1 or TEF4), are probably dimerized via the eF1Bgamma subunits. eEF1A interacts directly with eEF1Balpha. Interacts with elongation factor 3 (YEF3 or HEF3), BNI1, SRV2 and ZPR1. Binds to actin and forms a ternary complex with BNI1 and profilin. Interacts with the proteasome, probably via RPT1. Interacts with CEX1 and NAP1. Interacts with GCN2 (via C-terminus); this interaction is direct, occurs in amino acid-repleted cells, may be stabilzed in a ribosome-dependent manner, reduces GCN2-mediated eIF-2-alpha phosphorylation and is lost in amino acid-starved cells and by uncharged tRNAs (PubMed:21849502). Associates with ribosomes (PubMed:21849502).
messages: There are two genes for eEF1A in yeast.
messages: cytoskeleton

559292:YOR334W
gene id: 559292:YOR334W
uniprot id: Q01926
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix (PubMed:12628916, PubMed:17827224, PubMed:20653776, PubMed:23999289). Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes (PubMed:11544180).
messages: Homopentamer (PubMed:23999289). Forms homooligomers. Interacts with MFM1 (PubMed:20653776).
messages: Mitochondrion inner membrane
messages: Present with 768 molecules/cell in log phase SD medium.
messages: Was originally (PubMed:1551905 and PubMed:8252639) identified in genetic screens for bona fide RNA splicing factors, but it has later been shown that not the MRS2 protein per se but certain magnesium concentrations are essential for group II intron splicing.

559292:YMR055C
gene id: 559292:YMR055C
uniprot id: P26448
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUB2 family.
messages: Interacts with BFA1.
messages: Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the GTP-binding protein TEM1 by the BFA1/BUB2 complex.
messages: spindle pole

559292:YGL037C
gene id: 559292:YGL037C
uniprot id: P53184
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the isochorismatase family.
messages: Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate.
messages: Cytoplasm
messages: Has a cis-peptide bond at 162-Val-Ala-163.
messages: Induced during the stationary phase of growth, by calorie restriction, by various hyperosmotic shocks or by low-intensity stress (at protein level).
messages: Inhibited by N-ethylmaleimide, HgCl(2) and PCMB. Competitively inhibited by NAD, NMN and 3-acetylpyridine.
messages: Nucleus
messages: Peroxisome
messages: Present with 7720 molecules/cell in log phase SD medium.

559292:YML127W
gene id: 559292:YML127W
uniprot id: Q03124
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RSC9 family.
messages: Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit plays a role in transcriptional response to stress. It is involved in both repression and activation of mRNAs regulated by the target of rapamycin (TOR) kinases, and in the synthesis of rRNA.
messages: Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
messages: Nucleus
messages: Present with 2610 molecules/cell in log phase SD medium.

559292:YJL110C
gene id: 559292:YJL110C
uniprot id: P42944
names: Miscellaneous
names: Subcellular Location Annotation
messages: Nucleus
messages: Present with 319 molecules/cell in log phase SD medium.

559292:YDR254W
gene id: 559292:YDR254W
uniprot id: P38907
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-N/CHL4 family.
messages: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
messages: Forms a heterodimer with IML3 (PubMed:12589047, PubMed:24075991). CHL4-IML3 is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). Interacts with CTF3 and CTF19 (PubMed:12589047).
messages: Nucleus
messages: Present with 606 molecules/cell in log phase SD medium.
messages: kinetochore

559292:YOL073C
gene id: 559292:YOL073C
uniprot id: Q08232
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the DSC E3 ligase complexes composed of at least TUL1, DSC2, DSC3, UBX3, CDC48 as well as VLD1 for the vacuole-localized complex or GLD1 for the Golgi/endosome-localized complex.
messages: Component of the DSC E3 ubiquitin ligase complexes that tags proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control.
messages: Membrane

559292:YIL165C
gene id: 559292:YIL165C
uniprot id: P40446
names: Caution
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
messages: Could be the product of a pseudogene. YIL165C seems to be the C-terminal part of a putative nitrilase-like protein formed of NIT1/YIL164C and YIL165C.

559292:YMR306W
gene id: 559292:YMR306W
uniprot id: Q04952
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane
messages: Mitochondrion
messages: N-glycosylated.
messages: Required for spore wall assembly.

559292:YDR511W
gene id: 559292:YDR511W
uniprot id: Q04401
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with SDH2 within an SDH1-SDH2 subcomplex.
messages: Mitochondrion
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDH2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. Acts together with SDHAF1 (SDH6).
messages: Present with 195 molecules/cell in log phase SD medium.

559292:YML042W
gene id: 559292:YML042W
uniprot id: P32796
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: By ethanol (PubMed:8420957). Repressed by galactose (PubMed:8420957).
messages: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
messages: Mitochondrion inner membrane
messages: Peroxisome
messages: Present with 450 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at Met-23 of isoform Mitochondrial.

559292:YDL059C
gene id: 559292:YDL059C
uniprot id: Q12223
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD52 family.
messages: Interacts with RAD51 and RAD52.
messages: Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA.
messages: Nucleus
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YCR084C
gene id: 559292:YCR084C
uniprot id: P16649
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
messages: Associates with CYC8/SSN6 to form the CYC8-TUP1 (or TUP1-SSN6) corepressor complex that is composed of 4 copies of TUP1 and one copy of CYC8. Interacts with histone H3, histone H4, MATALPHA2, RFX1, SKO1, PGD1, HDA1, HDA2, HOS1, HOS2 and RPD3.
messages: Belongs to the WD repeat TUP1 family.
messages: Nucleus
messages: Present with 5840 molecules/cell in log phase SD medium.

559292:YOR046C
gene id: 559292:YOR046C
uniprot id: P20449
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. Contributes to the blocking of bulk poly(A)+ mRNA export in ethanol-stressed cells. May also be involved in early transcription.
messages: Associates with the nuclear pore complex. Interacts with NUP159, GLE1, GFD1 and ZDS1. The interaction with NUP159 is necessary for the association to the nuclear pore complex. Interacts also with the TFIIH complex subunits TFB1, TFB2 and RAD3.
messages: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
messages: Cytoplasm
messages: Nucleus membrane
messages: Present with 14900 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nuclear pore complex

559292:YBR074W
gene id: 559292:YBR074W
uniprot id: P38244
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: May be involved in vacuolar sorting and osmoregulation.
messages: N-glycosylated.
messages: Vacuole membrane

559292:YKL198C
gene id: 559292:YKL198C
uniprot id: P36002
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Essential determinant for low-affinity spermidine transport.

559292:YDR084C
gene id: 559292:YDR084C
uniprot id: P38962
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TVP23 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Interacts with YIP4 and YIP5.
messages: Present with 1040 molecules/cell in log phase SD medium.

559292:YDR183W
gene id: 559292:YDR183W
uniprot id: Q04004
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosducin family.
messages: Cytoplasm
messages: Interacts with the G protein beta-gamma subunit complex (STE4-STE18 complex).
messages: Not essential for growth. Inhibits early G-protein signaling events following pheromone stimulation. May help create heterodimerizable beta-tubulin by facilitating the efficient transfer of nascent beta-tubulin polypeptides to the folding apparatus.
messages: Present with 2250 molecules/cell in log phase SD medium.

559292:YFL029C
gene id: 559292:YFL029C
uniprot id: P43568
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

559292:YGR116W
gene id: 559292:YGR116W
uniprot id: P23615
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT6 family.
messages: Chromosome
messages: Interacts with CTR9.
messages: Nucleus
messages: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.
messages: Present with 8890 molecules/cell in log phase SD medium.

559292:YDR006C
gene id: 559292:YDR006C
uniprot id: P40317
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP11 family.
messages: High copy suppressor of a cyclic AMP-dependent protein kinase mutant.
messages: Nucleus

559292:YDR449C
gene id: 559292:YDR449C
uniprot id: Q02354
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP6 family.
messages: Component of the SSU processome, a pre-ribosomal particle required for the maturation of the 18S rRNA from the 35S pre-rRNA precursor.
messages: Component of the ribosomal small subunit (SSU) processome, or 90S pre-ribosomal particle, composed of the 35S pre-rRNA precursor, the U3 snoRNA, and at least 40 protein subunits. Component of the PWP2/UTP-B subcomplex composed of DIP2, PWP2, UTP6, UTP13, UTP18 and UTP21. Interacts with U3 snoRNA. Interacts with MPP10.
messages: Present with 7520 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDL078C
gene id: 559292:YDL078C
uniprot id: P32419
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.
messages: Peroxisome
messages: Present with 3300 molecules/cell in log phase SD medium.
messages: Yeast contains at least 3 malate dehydrogenase isoenzymes: a mitochondrial (MDH1), a cytoplasmic (MDH2) and a peroxisomal (MDH3).

559292:YGR238C
gene id: 559292:YGR238C
uniprot id: P50090
names: Miscellaneous
names: Subunit
messages: Interacts with KEL1.
messages: Present with 468 molecules/cell in log phase SD medium.

559292:YNL218W
gene id: 559292:YNL218W
uniprot id: P40151
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: Involved in the maintenance of proper DNA topology and chromosome integrity via annealing of single-stranded DNA breaks. Modulates DNA polymerase delta during replication or replication-associated repair. May function as a modulator for SGS1 when DNA is damaged.
messages: Nucleus
messages: Present with 1180 molecules/cell in log phase SD medium.

559292:YNL250W
gene id: 559292:YNL250W
uniprot id: P12753
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer (By similarity). Forms a complex with MRE11.
messages: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity. Rad50 provides ATP-dependent control of mre11 by unwinding and/or repositioning DNA ends into the mre11 active site.
messages: Present with 830 molecules/cell in log phase SD medium.
messages: The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer.

559292:YNR061C
gene id: 559292:YNR061C
uniprot id: P53747
names: Miscellaneous
names: Subcellular Location Annotation
messages: Present with 339 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YDL177C
gene id: 559292:YDL177C
uniprot id: Q12257
names: Miscellaneous
names: Similarity
messages: Belongs to the IMPACT family.
messages: Present with 907 molecules/cell in log phase SD medium.

559292:YER079W
gene id: 559292:YER079W
uniprot id: P40052
names: Miscellaneous
messages: Present with 1890 molecules/cell in log phase SD medium.

559292:YLL040C
gene id: 559292:YLL040C
uniprot id: Q07878
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS13 family.
messages: Compromises mitochondrial function and integrity, increases mitophagy (PubMed:27280386, PubMed:34830155, PubMed:32690699). Vacuolar protein missorting (PubMed:27280386, PubMed:28334785). Decreases number of clathrin-coated vesicles in cell (PubMed:34830155). Abnormal cortical reticulophagy; decreases packaging of endoplasmic reticulum (ER) into autophagosomes (PubMed:32690699). Abnormal sporulation; defective prospore membrane formation (PubMed:27280386, PubMed:24036347, PubMed:22442115). Accumulation of vesicles within the prospore membrane lumen and reduction of phosphatidylinositol and phosphatidic acid in the membrane (PubMed:22442115, PubMed:24036347). Abnormal actin cytoskeleton organization (PubMed:28334785). Sensitive to the arginine analog canavanine (PubMed:34830155, PubMed:28334785). Synthetic lethal with MMM1 (PubMed:26370498, PubMed:27280386). Localization of SPO71 to the prospore membrane is normal (PubMed:24036347).
messages: Endosome membrane
messages: Interacts (via SHR-BD domain) with SPO71 (via PxP motif); during prospore membrane formation (PubMed:24036347, PubMed:30018089). Interacts (via SHR-BD domain) with YPT35 (via PxP motif) (PubMed:30018089). Interacts (via SHR-BD domain) with MCP1 (via PxP motif) (PubMed:30018089, PubMed:28864540). Interacts with CDC31 (PubMed:28122955). Interacts (via C-terminus) with ARF1; the interaction is direct (PubMed:34830155). Interacts with the actin cytoskeleton (PubMed:28334785).
messages: Mediates the transfer of lipids between membranes at organelle contact sites (PubMed:30093493, PubMed:24036347, PubMed:22442115). Binds phospholipids, including phosphatidic acid (PA), phosphorylated phosphatidylinositol (PI), phosphatidylcholine (PC), phosphatidylethanolamine (PE), ceramide, and phosphatidylserine (PS) (PubMed:30093493, PubMed:34830155, PubMed:28122955, PubMed:28334785). Involved in mitochondrial lipid homeostasis, in a MCP1-dependent manner (PubMed:27280386, PubMed:34830155, PubMed:32690699). Involved in cortical reticulophagy (also known as cortical endoplasmic reticulum (ER) macroautophagy), acting at the late endosome to package ER into autophagosomes (PubMed:32690699). Involved in the formation of the prospore membrane during sporulation, in a SPO71-dependent manner (PubMed:24036347, PubMed:22442115). Involved in Golgi vesicle transport, in a CDC31-dependent and ARF1-dependent manner (PubMed:28122955, PubMed:9314526, PubMed:34830155). Plays a role in actin cytoskeleton organization (PubMed:28334785).
messages: Mitochondrion outer membrane
messages: Nucleus outer membrane
messages: Peroxisome
messages: Present with 125 molecules/cell in log phase SD medium.
messages: Prospore membrane
messages: The SHR-BD domain binds to PxP motifs found in interaction partners.
messages: Vacuole membrane
messages: trans-Golgi network membrane

559292:YPL027W
gene id: 559292:YPL027W
uniprot id: Q02651
names: Function
messages: Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane.

559292:YMR210W
gene id: 559292:YMR210W
uniprot id: Q03649
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
messages: Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Has a preference for palmitoyl-MAG (PubMed:26991558). Does not play a significant role in ethyl ester biosynthesis (PubMed:16361250). Also possesses ester hydrolase and low but persistent TAG lipase activity (PubMed:29225428).

559292:YEL027W
gene id: 559292:YEL027W
uniprot id: P25515
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Present with 8450 molecules/cell in log phase SD medium.
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1825730). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1825730).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (PubMed:25971514, PubMed:27776355, PubMed:29526695). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c'' (PubMed:25971514, PubMed:27776355, PubMed:29526695).
messages: Vacuole membrane

559292:YBR217W
gene id: 559292:YBR217W
uniprot id: P38316
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5. Forms a thioester bond with the 'Cys-133' of ATG10. Interacts with the ATG7 C-terminal 40 amino acids domain. The ATG12-ATG5 conjugate forms a complex with several units of ATG16. The ATG12-ATG5 conjugate associates also with ATG3. Interacts with COG2.
messages: Preautophagosomal structure membrane
messages: Small amount of ATG5-ATG12 conjugate is enough to perform normal autophagy.
messages: Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity.

559292:YJL209W
gene id: 559292:YJL209W
uniprot id: P07252
names: Function
names: Miscellaneous
messages: Present with 2180 molecules/cell in log phase SD medium.
messages: Responsible for conferring a stable 5'-end on cytochrome b mRNA.

559292:YOL102C
gene id: 559292:YOL102C
uniprot id: Q12272
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
messages: Present with 672 molecules/cell in log phase SD medium.

559292:YNL063W
gene id: 559292:YNL063W
uniprot id: P53944
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein N5-glutamine methyltransferase family.
messages: Methylates MRF1 on 'Gln-287' using S-adenosyl L-methionine as methyl donor.
messages: Mitochondrion
messages: Present with 13200 molecules/cell in log phase SD medium.

559292:YDR188W
gene id: 559292:YDR188W
uniprot id: P39079
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

559292:YIL020C
gene id: 559292:YIL020C
uniprot id: P40545
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR.
messages: Cytoplasm
messages: Present with 6490 molecules/cell in log phase SD medium.

559292:YMR145C
gene id: 559292:YMR145C
uniprot id: P40215
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxidation.
messages: Mitochondrion intermembrane space
messages: Present with 4930 molecules/cell in log phase SD medium.

559292:YCR034W
gene id: 559292:YCR034W
uniprot id: P25358
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Component of a microsomal membrane-bound long-chain fatty acid elongation system, which produces the 20-26-carbon very long-chain fatty acids (VLCFA) from long-chain fatty acid precursors and is involved ceramide and inositol sphingolipid biosynthesis. Component of elongase II, which elongates 16-18 carbon fatty acyl-CoAs such as palmitoyl-CoA and stearoyl-CoA to 20-22-carbon fatty acids by incorporation of malonyl-CoA (PubMed:9211877, PubMed:12684876). Involved in the synthesis of 1,3-beta-glucan (PubMed:7768822). The enzymes active site faces the cytosol, whereas VLCFA length is determined by a lysine near the luminal end of transmembrane helix 6 (PubMed:17719544). Plays an important role in lipotoxic cell death induced by oleic acid through maintaining a balanced fatty acid composition in thr plasma membrane (PubMed:29458843).
messages: Endoplasmic reticulum membrane
messages: Present with 3510 molecules/cell in log phase SD medium.
messages: The C-terminal di-lysine-like motif may confer endoplasmic reticulum localization.
messages: The HxxHH motif is essential for ELOp function in vivo and 3-keto acyl-CoA synthase activity in vitro.

559292:YOL039W
gene id: 559292:YOL039W
uniprot id: P05319
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A (PubMed:16573688, PubMed:11431471).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Phosphorylation is not involved in the interaction of the acidic P proteins with the ribosome, however it is suggested to affect the ribosome activity and to participate in a possible ribosome regulatory mechanism.
messages: Present with 428000 molecules/cell in log phase SD medium.
messages: The 4 small acidic ribosomal P-proteins from yeast can be classified into two couples of similar but not identical sequences. Each couple (P1A/P1B and P2A/P2B) is distinctly related to one of the two acidic ribosomal P-proteins P1/P2 present in multicellular organisms.
messages: The N-terminus is not modified.

559292:YDR323C
gene id: 559292:YDR323C
uniprot id: P32609
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with VPS21, VPS45, PEP3 and PEP5.
messages: Present with 768 molecules/cell in log phase SD medium.
messages: Required for vacuole segregation and vacuole protein sorting. Possibly part of a complex which tethers the vacuole membrane to microtubules, either directly or via kinesin or dynein-like motor proteins. Probably functions in several interorganelle traffic pathways.
messages: Vacuole membrane

559292:YIL006W
gene id: 559292:YIL006W
uniprot id: P40556
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial inner membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:16291748, PubMed:32906142, PubMed:33087354). Can transport NAD(+) by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP (PubMed:16291748). Also able to transport NAD(+) by exchange with AMP, GMP or deamido-NAD (+) in vitro (PubMed:16291748).
messages: Mitochondrion inner membrane
messages: Was first identified as the mitochondrial pyruvate transporter (PubMed:12887330). However, later experiments showed that was a NAD(+) transporter (PubMed:16291748).

559292:YJR076C
gene id: 559292:YJR076C
uniprot id: P32458
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SHS1 and rearranges to a cortical collar of highly ordered filaments at the mother-bud-neck. A complex formed by CDC3, CDC10, CDC11 and CDC12 is capable of forming long filaments in vitro and the components seem to be present in a 2:2:2:2 arrangement in vivo. The filaments are proposed to be formed by the end-to-end polymerization of CDC3-CDC12-CDC11 complexes with CDC10 serving as a bridge to bundle the polymers into paired filaments. Component of the GIN4 complex composed of at least BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. Self-associates. Interacts with BEM4, KCC4, SPR28 and SYP1.
messages: Membrane
messages: Present with 9280 molecules/cell in log phase SD medium.
messages: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
messages: Sumoylated during mitosis on the mother cell side of the bud neck. Sumoylation probably plays a central role in regulating septin ring disassembly during the cell cycle.
messages: The basic motif is essential for the association with PI(4)P and PI(5)P.
messages: The coiled coil domain is required for the interaction with CDC3 and BEM4, but not for interaction with CDC12 or with itself.

559292:YHR167W
gene id: 559292:YHR167W
uniprot id: O13539
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the THO complex, which is composed of HPR1, MFT1, THO2 and THP2. Together with SUB2, TEX1 and YRA1, THO forms the transcription/export (TREX) complex. THO associates with DNA and RNA in vitro.
messages: Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
messages: Nucleus
messages: Present with 2840 molecules/cell in log phase SD medium.

559292:YMR105C
gene id: 559292:YMR105C
uniprot id: P37012
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor.
messages: Blocks galactose utilization, but does not impair growth on glucose.
messages: Cytoplasm
messages: Induced in response to galactose and severely repressed in response to glucose.
messages: Major phosphoglucomutase isozyme that catalyzes the reversible interconversion of glucose 1-phosphate and glucose 6-phosphate (PubMed:5784209). Constitutes about 80-90% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755). Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884).
messages: Monomer.
messages: O-glycosylated with mannose residues (By similarity). Substrate of UDP-glucose--glycoprotein glucose phosphotransferase, linking glucose in a phosphodiester linkage to O-linked mannose (PubMed:8385141, PubMed:7929458).
messages: Present with 3790 molecules/cell in log phase SD medium.

559292:YGR268C
gene id: 559292:YGR268C
uniprot id: P40325
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HUA1 family.
messages: Cytoplasm
messages: May be involved in assembly and disassembly of the actin cytoskeleton.

559292:YNL275W
gene id: 559292:YNL275W
uniprot id: P53838
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole.
messages: Present with 195 molecules/cell in log phase SD medium.
messages: Vacuole membrane

559292:YLR032W
gene id: 559292:YLR032W
uniprot id: P32849
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Cytoplasm
messages: Homodimer. Interacts with POL30, RAD18, UBC9 and UBC13.
messages: Nucleus
messages: Present with 1520 molecules/cell in log phase SD medium.
messages: Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with the DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs. Recruits the UBC13-MMS2 dimer to chromatin for DNA repair.

559292:YDR077W
gene id: 559292:YDR077W
uniprot id: Q01589
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SED1 family.
messages: Component of the cell wall. Major cell wall protein in stationary phase cells. Required to stabilize the cell wall in the absence of multiple GPI-anchored mannoproteins.
messages: Induced in stationary phase and under conditions of stress and starvation (at protein level).
messages: Membrane
messages: Present with 1630 molecules/cell in log phase SD medium.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The N-terminus is blocked.
messages: The number of the intragenic tandem repeats varies between different S.cerevisiae strains.
messages: cell wall

559292:YIL136W
gene id: 559292:YIL136W
uniprot id: P16547
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AIM5, FCJ1 and MOS1.
messages: Mitochondrion outer membrane
messages: Present with 6490 molecules/cell in log phase SD medium.

559292:YPR149W
gene id: 559292:YPR149W
uniprot id: Q12207
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCE102 family.
messages: Cell membrane
messages: Involved in membrane organization. Required for the formation of membrane compartments of CAN1 (MCCs), localization of CAN1 at the MCCs and subsequent invagination of the plasma membrane at the MCCs sites. Involved in eisosome organization and might act as a sensor of sphingolipids that regulates plasma membrane function. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. It may be an accessory subunit to an essential core component of the non-classical export machinery. Non-classical export pathway functions also as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient.
messages: The C terminus is necessary to target MCC-specific transporters into MCC and for the formation of the plasma membrane invaginations.

559292:YMR044W
gene id: 559292:YMR044W
uniprot id: Q04213
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ISW1B complex, which at least consists of ISW1, IOC2 and IOC4.
messages: Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.
messages: Nucleus
messages: Present with 5820 molecules/cell in log phase SD medium.

559292:YCL004W
gene id: 559292:YCL004W
uniprot id: P25578
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids.
messages: Mitochondrion
messages: Repressed by inositol and choline.

559292:YKL190W
gene id: 559292:YKL190W
uniprot id: P25296
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family.
messages: Composed of a catalytic subunit (A) and a regulatory subunit (B).
messages: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
messages: This protein has four functional calcium-binding sites.

559292:YDR465C
gene id: 559292:YDR465C
uniprot id: Q03305
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Cytoplasm
messages: Monomer. Interacts with nucleoporins NUP49, NUP57 and NUP100.
messages: Nucleus
messages: Present with 1600 molecules/cell in log phase SD medium.
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins (PubMed:9873020). Monomethylates ribosomal protein L12 (RPL12A/RPL12B) at 'Arg-67' (PubMed:11856739).

559292:YIL033C
gene id: 559292:YIL033C
uniprot id: P07278
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Binding of cAMP to the 2 tandem cyclic-nucleotide binding domains (CNB-A and CNB-B) induces a conformational change in BCY1, causing the interaction surface with the catalytic subunit to be destroyed and eventually the dissociation of the R dimer from the C subunits.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by YAK1 in response to glucose starvation. Phosphorylated by MCK1 at Thr-129 upon TOR complex 1 (TORC1) inhibition. Thr-129 phosphorylation activates BCY1 to inhibit PKA. TORC1 inhibits phosphorylation of RxxS/T sites but has no effect on Ser-145 phosphorylation. The phosphorylation sites can be clustered in several groups, all localized in the N-terminal part. The first cluster termed cluster I (CI) is located close to the N-terminus and includes Ser-3, Ser-4 and Ser-9 (PubMed:11134339, PubMed:12704202). The second includes Ser-68, Ser-70, Ser-74, Ser-77, Ser-79, Ser-81, Ser-83, and Ser-84. This cluster of phosphorylation sites, termed cluster II (CII), is important for BCY1 cytoplasmic localization and function (PubMed:11134339, PubMed:12704202, PubMed:20702584). The third cluster of phosphorylated residues consists of Thr-144, Ser-145, Ser-147, Thr-150, and Thr-160. This cluster falls within or near the so-called autoinhibitory domain where the catalytic subunit of PKA autophosphorylates the highly conserved Ser-145 to inhibit BCY1 (PubMed:20702584). A last cluster of phosphorylated residues included Thr-129, Ser-130, and Thr-131 and is termed cluster III (CIII). Sites in CIII (and to a lesser extent in CII) are hyperphosphorylated in response to rapamycin (PubMed:20702584).
messages: Present with 4280 molecules/cell in log phase SD medium.
messages: Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), an effector of the Ras/cAMP pathway. Inhibits PKA activity in the absence of cAMP. cAMP activates PKA and promotes growth and proliferation in response to good nutrient conditions. Together with ZDS1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1.
messages: The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer, composed of 2 regulatory subunits (R, encoded by BCY1) and two catalytic subunits (C, encoded by the 3 partially redundant TPK1, TPK2, and TPK3 genes). Activation by cAMP causes dissociation of the holoenzyme, producing 2 active catalytic monomers C and a regulatory dimer R(2).
messages: The inhibitor sequence (IS) is a substrate recognition motif that docks to the active site cleft of the catalytic subunit rendering the holoenzyme inactive.

559292:YML102W
gene id: 559292:YML102W
uniprot id: Q04199
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts (By similarity).
messages: Belongs to the WD repeat HIR1 family.
messages: Component of chromatin assembly factor 1 (CAF-1), which is composed of MSI1/p50, CAC2/p60 and CAC1/p90 (Probable). Interacts with RTT106 (PubMed:19683497).
messages: Nucleus
messages: Present with 2130 molecules/cell in log phase SD medium.

559292:YNL133C
gene id: 559292:YNL133C
uniprot id: P53913
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV6 family.
messages: Involved in telomere length regulation and required for survival upon exposure to K1 killer toxin. Promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase.
messages: Nucleus
messages: Present with 468 molecules/cell in log phase SD medium.
messages: telomere

559292:YML076C
gene id: 559292:YML076C
uniprot id: Q03631
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Phosphorylation is required for PDR12 induction.
messages: Present with 907 molecules/cell in log phase SD medium.
messages: transcription factor which binds to a weak acid response element (WARE) to mediate stress induction of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively.

559292:YDL135C
gene id: 559292:YDL135C
uniprot id: Q12434
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rho GDI family.
messages: Cytoplasm
messages: Present with 1670 molecules/cell in log phase SD medium.
messages: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

559292:YMR212C
gene id: 559292:YMR212C
uniprot id: Q03653
names: Miscellaneous
names: Similarity
messages: Belongs to the EFR3 family.
messages: Present with 1670 molecules/cell in log phase SD medium.

559292:YCR083W
gene id: 559292:YCR083W
uniprot id: P25372
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family.
messages: Mitochondrion
messages: Present with 1010 molecules/cell in log phase SD medium.
messages: Yeast has two cytoplasmic thioredoxins, TRX1 and TRX2, and one mitochondrial, TRX3.

559292:YBR095C
gene id: 559292:YBR095C
uniprot id: P38255
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RXT2 family.
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
messages: Nucleus
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YDL005C
gene id: 559292:YDL005C
uniprot id: Q12124
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mediator complex subunit 2 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
messages: Component of the Mediator complex, which is composed of at least 21 subunits that form three structurally distinct submodules. The Mediator head module contains MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins.
messages: Nucleus
messages: Present with 10785 molecules/cell in log phase SD medium.

559292:YOR252W
gene id: 559292:YOR252W
uniprot id: Q08687
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMA16 family.
messages: Nucleus
messages: Present with 5350 molecules/cell in log phase SD medium.

559292:YNL002C
gene id: 559292:YNL002C
uniprot id: P40693
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs.
messages: Present with 7720 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR283C
gene id: 559292:YDR283C
uniprot id: P15442
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (orthologuous-specific) Binds to aminoacylated tRNA(Phe) less tightly than to deacylated tRNA(Phe) (PubMed:10983975). Binds to double-stranded RNA (PubMed:9430731).
messages: Abolishes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) during amino acid, purine, and glucose starvation (PubMed:8336737, PubMed:10733573). Inhibits GCN4 derepression in glucose, amino acid, or purine-starved cells (PubMed:8336737, PubMed:10733573). Decreases vacuolar free amino acid levels during glucose starvation (PubMed:10733573). Sensitive to the purine analog 8-azaadenine (PubMed:8336737). Increases duration of lag phase on return to glucose-rich medium following glucose starvation (PubMed:10733573).
messages: Autophosphorylated, autophosphorylation on Thr-882 and Thr-887 increases kinase activity.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
messages: Cytoplasm
messages: Homodimer; homodimerization is important for kinase activation by uncharged tRNAs (PubMed:9566889, PubMed:10983975, PubMed:11250908, PubMed:17202131, PubMed:15964839). Interacts (via N-terminal RWD domain) with GCN1 (via N- and C-terminus); this interaction stimulates GCN2 kinase activity in a GCN20-dependent manner in response to amino acid starvation (PubMed:10775272, PubMed:11101534, PubMed:10801780, PubMed:11350982, PubMed:21849502). Interacts (via N-terminus) with the GCN1-GCN20 complex on translating ribosomes in amino acid-starved cells; GCN1 may bind near the ribosomal A-site and promotes the transfer of uncharged tRNAs from the A-site to the tRNA-binding domain in GCN2 for its subsequent kinase activation, and hence allowing GCN4 translational activation and derepression of amino acid biosynthetic genes (PubMed:10775272, PubMed:11101534). Interacts (via C-terminus) with TIF11; this interaction is direct, occurs in amino acid-repleted cells, may be stabilzed in a ribosome-dependent manner, reduces GCN2-mediated eIF-2-alpha phosphorylation but not GCN2 autophosphorylation and is lost in amino acid-starved cells and by uncharged tRNAs (PubMed:21849502). Associates (via C-terminus) with ribosomes (PubMed:2038314, PubMed:9430731, PubMed:10983975, PubMed:22888004).
messages: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) on 'Ser-52' in response to low amino acid, carbon, or purine availability (PubMed:1739968, PubMed:7623840, PubMed:8798780, PubMed:9528799, PubMed:10983975, PubMed:17202131, PubMed:8336737, PubMed:10733573). Plays a role as an activator of the general amino acid control (GAAC) pathway required for adapatation to nutrient starvation. Converts phosphorylated eIF-2-alpha/SUI2 either to a competitive inhibitor of translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator GCN4, and hence allowing GCN4-mediated reprogramming of transcription to alleviate nutrient depletion (PubMed:2660141, PubMed:2188100, PubMed:1739968, PubMed:7621831, PubMed:7623840, PubMed:8798780, PubMed:10801780, PubMed:11350982, PubMed:24333428, PubMed:10733573). Binds uncharged tRNAs (PubMed:7623840, PubMed:10983975).
messages: Present with 279 molecules/cell in log phase SD medium.
messages: The C-terminal domain negatively regulates kinase activity via an autoinhibitory association with the protein kinase and histidyl-tRNA synthetase-like domains in amino acid-repleted cells, that is counteracted by uncharged tRNAs in amino acid-starved cells (PubMed:7623840, PubMed:8798780, PubMed:10983975, PubMed:11250908). The C-terminal, histidyl-tRNA synthetase-like region and protein kinase domains are necessary for homodimer formation (PubMed:9566889, PubMed:10983975, PubMed:11250908). The C-terminal and protein kinase domains are necessary for ribosome association (PubMed:9566889, PubMed:10983975). The C-terminal and histidyl-tRNA synthetase-like regions are required for uncharged tRNAs binding in amino acid-starved cells (PubMed:7623840, PubMed:8798780, PubMed:9430731, PubMed:10983975).
messages: The kinase activity is stimulated upon binding to uncharged tRNAs (PubMed:7623840).

559292:YPR047W
gene id: 559292:YPR047W
uniprot id: P08425
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.
messages: Mitochondrion matrix
messages: Monomer.
messages: Present with 1800 molecules/cell in log phase SD medium.

559292:YIL154C
gene id: 559292:YIL154C
uniprot id: P32351
names: Function
names: Miscellaneous
messages: Controls the nucleo-mitochondrial dependence of galactose, maltose and raffinose utilization. Becomes essential in the absence of functioning mitochondria.
messages: Present with 5110 molecules/cell in log phase SD medium.

559292:YLL023C
gene id: 559292:YLL023C
uniprot id: Q12164
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PER33/POM33 family.
messages: Contributes to proper distribution and/or efficient assembly of nuclear pores. Required for normal pore density in the daughter nucleus during telophase.
messages: Endoplasmic reticulum membrane
messages: Interacts with RTN1.
messages: Present with 1680 molecules/cell in log phase SD medium.
messages: nuclear pore complex

559292:YPL217C
gene id: 559292:YPL217C
uniprot id: Q08965
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with RCL1.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.
messages: Cytoplasm
messages: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus. The depletion of BMS1 interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits.
messages: nucleolus

559292:YIL024C
gene id: 559292:YIL024C
uniprot id: P40543
names: Miscellaneous
messages: Present with 1540 molecules/cell in log phase SD medium.

559292:YDR528W
gene id: 559292:YDR528W
uniprot id: Q04429
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cell wall composition and integrity and response to osmotic stress.
messages: Present with 259 molecules/cell in log phase SD medium.

559292:YOR078W
gene id: 559292:YOR078W
uniprot id: Q08492
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP16 family.
messages: Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in bud site selection maybe via the regulation of expression of bipolar budding components.
messages: Present with 2120 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR363C
gene id: 559292:YLR363C
uniprot id: Q12129
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
messages: Present with 6090 molecules/cell in log phase SD medium.

559292:YNL015W
gene id: 559292:YNL015W
uniprot id: P0CT04
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I9 family.
messages: Cytoplasm
messages: Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis. PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi.
messages: Originally, 2 inhibitors of protease B, inhibitor I(B)2 and inhibitor I(B)1, have been isolated from commercial baker's yeast, which consists of both S.cerevisiae and S.carlsbergensis. It has been shown that S.cerevisiae only produces inhibitor 2, and S.carlsbergensis only produces inhibitor 1 (PubMed:328499). A sequence for inhibitor 1 from S.carlsbergensis has been determined (AC P0CT05).
messages: Part of the heterodimeric LMA1 complex together with the thioredoxin II/TRX2. LMA1 binds to the ATPase SEC18.

559292:YKL022C
gene id: 559292:YKL022C
uniprot id: P09798
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC6/CDC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
messages: Nucleus
messages: Phosphorylated by CDC28, which is required for the early mitotic activity of the APC/C in its CDC20-bound form.
messages: Present with 2753 molecules/cell in log phase SD medium.
messages: The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1. Interacts with AMA1.

559292:YGL161C
gene id: 559292:YGL161C
uniprot id: P53108
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YIP1 family.
messages: Interacts with SNX3, TVP18, TVP23, YIP1 and YIP4. Interacts with SEC4; The C-terminal cysteines in the Rab GTPase SEC4 are essential for the interaction. Interacts with YPT1, YPT6, YPT7, YPT10, YPT11, YPT31, YPT32 and YPT52; These proteins are all Rab GTPases.
messages: Membrane
messages: Possible role in vesicle-mediated transport. May be involved in proper membrane localization of Rab GTPases.
messages: Present with 937 molecules/cell in log phase SD medium.

559292:YHR007C
gene id: 559292:YHR007C
uniprot id: P10614
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Expression is increased during growth on glucose, in the presence of heme, and during oxygen limiting growth conditions and, unexpectedly, during anaerobic growth (PubMed:1730736). Two upstream activating sequences, UASl and UASZ, and an upstream repressor element, URS1, plus a second possible or cryptic repressor element, URSP, are present in promoter (PubMed:1730736). HAP1 participates in activation from UASl but not from UAS2, whereas the ROXl repressor represses expressio of ERG11 (PubMed:1730736).
messages: Interacts with ERG28.
messages: It is the main target for antifungal compounds of the triazole family like ketoconazole which inhibits by coordinating the iron atom at the sixth ligand position.
messages: Lanosterol 14-alpha demethylase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:369554, PubMed:105731). ERG11 catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis (PubMed:369554, PubMed:105731). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 ca…
messages: Present with 73200 molecules/cell in log phase SD medium.

559292:YOR274W
gene id: 559292:YOR274W
uniprot id: P07884
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in the anticodon loop on a specific subset of tRNAs both in the cytosol and the mitochondrion, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This modification optimizes the codon:anticodon fit in the ribosome and promotes translational fidelity. Competes with the farnesyl pyrophosphate synthase ERG20 for the common substrate dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus
messages: Present with 2020 molecules/cell in log phase SD medium.
messages: The core aggregation region, although lacking the prion-typical Gln/Asn (Q/N)-rich domain, is required for the formation of the amyloid-like fibrillar aggregates.
messages: [MOD+] is the prion form of MOD5. [MOD+] is the result of a conformational change of the cellular MOD5 protein that becomes self-propagating and infectious. This conformational change generates a form of MOD5 that assembles into amyloid-like fibrillar aggregates. [MOD+]-aggregates sequester soluble MOD5, resulting in decreased levels of (i(6)A)-modified tRNAs and higher ergosterol levels, due to less competition for ERG20, which uses the same substrate DMAPP than MOD5. [MOD+] can be cured by GdnHCl and by deletion of the molecular chaperone HSP104, which is required for [MOD+] propagation. The [MOD+] state acquires resistance against antifungal agents such as flucanozole, ketoconazole and clotrimazole that inhibit ergosterol biosynthesis. De novo appearance of [MOD+] is favored in the presence of antifungal agents, and the growth advantage of [MOD+] is lost when the cells are released from the selective pressure. Thus, the conformational switch of MOD5 from a soluble state to a prion state allows the cell to adapt to the harmful environment of anti-fungal drugs by up-regulating ergosterol biosynthesis at the expense of tRNA modification.

559292:YGR263C
gene id: 559292:YGR263C
uniprot id: P53324
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Endoplasmic reticulum membrane
messages: Required for the deacetylation of acetylated sterols. Involved in the resistance to eugenol and pregnenolone toxicity.

559292:YDR263C
gene id: 559292:YDR263C
uniprot id: Q12086
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease.
messages: Belongs to the XPG/RAD2 endonuclease family.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: By UV light, methyl methane-sulfonate (MMS) or hydroxyurea (HU), and during meiosis.
messages: Nucleus

559292:YHR206W
gene id: 559292:YHR206W
uniprot id: P38889
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKN7 family.
messages: Homotrimer.
messages: Homotrimerization occurs through formation of a three-stranded coiled-coil structure generated by intermolecular interactions between HR-A/B regions allowing DNA-binding activity.
messages: Nucleus
messages: Present with 2570 molecules/cell in log phase SD medium.
messages: The phosphorelay mechanism involves the sequential transfer of a phosphate group from 'His-576' (H1) to 'Asp-1144' (D1) of SLN1, then to 'His-64' (H2) of YPD1 and finally to Asp-427 (D2) of SKN7.
messages: Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.

559292:YNL242W
gene id: 559292:YNL242W
uniprot id: P53855
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Impairs the formation of autophagosomes (PubMed:28704456). Completely blocks the movement of the ER-staining dye R18 from the ER to IM precursors (PubMed:28704456).
messages: Interacts with ATG18 (PubMed:17295840, PubMed:18586673, PubMed:22851171, PubMed:23230146, PubMed:30254161). Interacts with ATG9 (PubMed:29848619).
messages: Lipid transfer protein required for autophagosome completion and peroxisome degradation (PubMed:8224160, PubMed:10029994, PubMed:11382760, PubMed:11382761, PubMed:11675007, PubMed:18586673, PubMed:18625846, PubMed:19371383, PubMed:19995911, PubMed:22728243, PubMed:23230146). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:28704456, PubMed:29848619, PubMed:30254161). ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region (PubMed:30254161). The latter binding is assisted by an ATG18-PtdIns3P interaction (PubMed:30254161). ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion (PubMed:30254161). ATG2 is also involved in the recruitment of lipids to a restricted region close to the vacuole, termed the vacuole-isolation membrane contact site (VICS), which is also essential for autophagosome formation (PubMed:28704456). Necessary for the localization of ATG18 to the preautophagosomal structure (PAS) and the binding of ATG18 to ATG9 (PubMed:14723849, PubMed:18586673, PubMed:18625846, PubMed:19371383, PubMed:23230146). ATG2 is the most downstream ATG protein in the preautophagosomal structure organization process (PubMed:17295840). Involved in correct ATG9 trafficking through the preautophagosomal structure and in peroxisome degradation (PubMed:14723849). Plays a significant role in life span extension (PubMed:23337777).
messages: Preautophagosomal structure membrane
messages: Present with 876 molecules/cell in log phase SD medium.
messages: The N-terminal region (NR) associates with the endoplasmic reticulum (ER) and is responsible for the formation of the isolation membrane at the PAS.
messages: The amphipathic helix in the C-terminal region binds to membranes and facilitates ATG18 binding to PtdIns3P to target the ATG2-ATG18 complex to the PAS.

559292:YJR049C
gene id: 559292:YJR049C
uniprot id: P21373
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homohexamer.
messages: Present with 5040 molecules/cell in log phase SD medium.
messages: Specifically phosphorylates NAD in the presence of ATP, dATP, or CTP as phosphoryl donors.
messages: Was briefly thought to be FRE2.

559292:YOR358W
gene id: 559292:YOR358W
uniprot id: Q02516
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP5 is essential for DNA-binding activity. It may be the linchpin that binds to the subunit association domains (SAD) of HAP2 and HAP3 to bring these proteins together.
messages: Belongs to the NFYC/HAP5 subunit family.
messages: Component of the CCAT-binding factor (CBF or HAP complex II), which consists of one copy each of HAP2, HAP3, HAP4 and HAP5. The assembly of the HAP2-HAP3-HAP5 heteromer (HAP complex I) occurs in a one-step pathway and its binding to DNA is a prerequisite for the association of HAP4.
messages: Nucleus
messages: Present with 450 molecules/cell in log phase SD medium.

559292:YLR376C
gene id: 559292:YLR376C
uniprot id: Q12318
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SHU complex composed of at least CSM2, PSY3, SHU1 and SHU2.
messages: Nucleus
messages: Present with 876 molecules/cell in log phase SD medium.
messages: Required for resistance to the DNA-damaging agents methyl methanesulfonate (MMS), cisplatin and oxaliplatin, but not to mitomycin C. Plays a role in protection against mutation accumulation. May be a component of the recombination-repair pathway.

559292:YML013W
gene id: 559292:YML013W
uniprot id: Q04228
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the DOA10 ubiquitin ligase complex which contains E3 ligase SSM4/DOA10 and CDC48-binding protein UBX2/SEL1 (PubMed:16873066). Component of the HRD1 ubiquitin ligase complex which contains the E3 ligase HRD1, its cofactors HRD3, USA1 and DER1, substrate recruiting factor YOS9 and UBX2 (PubMed:16873066). In ERAD-L, HRD3 and YOS9 jointly bind misfolded glycoproteins in the endoplasmic reticulum (ER) lumen (PubMed:32327568). Movement of ERAD-L substrates through the ER membrane is facilitated by HRD1 and DER1 which have lateral gates facing each other and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568). Both the DOA10 and HRD1 ubiquitin ligase complexes interact with the heterotrimeric CDC48-NPL4-UFD1 ATPase complex which is recruited by UBX2 via its interaction with CDC48 and which moves ubiquitinated substrates to the cytosol for targeting to the proteasome (PubMed:15258615, PubMed:16179953, PubMed:16179952, PubMed:16873066).
messages: Endoplasmic reticulum membrane
messages: Integral endoplasmic reticulum membrane protein that coordinates the assembly of the ER-associated protein degradation (ERAD) machinery at the ER membrane. Mediates binding of CDC48 to the E3 ubiquitin ligases SSM4/DOA10 and HRD1, and to ERAD substrates. Component of the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. ERAD-C substrates are ubiquitinated through DOA10 in conjunction with the E2 ubiquitin-conjugating enzymes UBC6 and UBC7-CUE1. Also a component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome.
messages: Present with 12600 molecules/cell in log phase SD medium.

559292:YCR021C
gene id: 559292:YCR021C
uniprot id: P25619
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Expressed during the entry into stationary phase resulting from glucose limitation.
messages: Membrane
messages: Present with 7800 molecules/cell in log phase SD medium.
messages: Probably cooperates with other heat shock proteins in the translocation of polypeptides through membranes. It may counteract the altering effect of heat shock on the plasma membrane.

559292:YBR249C
gene id: 559292:YBR249C
uniprot id: P32449
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: By amino acid starvation.
messages: Inhibited by tyrosine.
messages: Present with 26300 molecules/cell in log phase SD medium.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

559292:YOR047C
gene id: 559292:YOR047C
uniprot id: Q02794
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with SNF1 kinase; via catalytic domain. Interacts with the glucose sensors SNF3 and RGT2.
messages: Involved in modulation of glucose-regulated gene expression. Together with MTH1, represses the hexose transporter (HXT) genes in conditions of low glucose. Stimulates the SNF1 kinase by an interaction with the catalytic domain that antagonizes autoinhibition and promotes an active conformation of the kinase.
messages: Nucleus
messages: Present with 238 molecules/cell in log phase SD medium.
messages: The prion state [GAR+] is provoked by the interaction of the two proteins STD1 and PMA1. It involves a complex between a small fraction of the cellular complement of PMA1, and STD1, a much lower-abundance protein, and it is transmissible by non-Mendelian, cytoplasmic inheritance. [GAR+] makes cells resistant to the glucose-associated repression of alternative carbon sources. In contrast to other prion forms, [GAR+] cannot be cured by GdnHCl or by inactivation of the molecular chaperone HSP104.
messages: To yeast MTH1.

559292:YDR152W
gene id: 559292:YDR152W
uniprot id: Q03768
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as a negative regulator of the GCN2 kinase activity by disrupting the GCN1-GCN2 interaction in amino acid-starved cells (PubMed:19448108).
messages: Belongs to the RWDD1/GIR2 family.
messages: Interacts with GCN1; this interaction prevents the interaction of GCN1 with GCN2 protein kinase and GCN2 activation in amino acid-starved cells (PubMed:19448108). Interacts with RBG1 (PubMed:19448108). Associates with ribosomes; the association occurs in a GCN1-dependent manner (PubMed:19448108).
messages: Present with 10300 molecules/cell in log phase SD medium.

559292:YBL102W
gene id: 559292:YBL102W
uniprot id: P38166
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Golgi apparatus membrane
messages: Lack of SFT2 is lethal in a strain lacking GOT1.
messages: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. Can be partially replaced by GOT1.
messages: Present with 279 molecules/cell in log phase SD medium.

559292:YLR212C
gene id: 559292:YLR212C
uniprot id: P53378
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Interacts with SPC72, SPC97 and SPC98.
messages: Present with 7200 molecules/cell in log phase SD medium.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. TUB4 is an important spindle pole body component that organizes both cytoplasmic and nuclear microtubule arrays.
messages: spindle pole body

559292:YBR087W
gene id: 559292:YBR087W
uniprot id: P38251
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair.
messages: Nucleus
messages: Present with 5040 molecules/cell in log phase SD medium.
messages: Replication factor C (RFC) is a heteropentamer of subunits RFC1, RFC2, RFC3, RFC4 and RFC5 and forms a complex with POL30/PCNA in the presence of ATP. Component of the RAD24-RFC complex which consists of RAD24, RFC2, RFC3, RFC4 and RFC5 and associates with the checkpoint clamp DDC1:MEC3:RAD17 complex. Component of the ELG1-RFC complex which consists of ELG1, RFC2, RFC3, RFC4 and RFC5. Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. RFC5 interacts with ECO1.

559292:YOL107W
gene id: 559292:YOL107W
uniprot id: Q12239
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM115 family.
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum.
messages: Present with 1630 molecules/cell in log phase SD medium.

559292:YNL299W
gene id: 559292:YNL299W
uniprot id: P48561
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B-like family.
messages: Catalytic subunit of the TRAMP5 complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. TRF5 is also required for proper nuclear division in mitosis and sister chromatid cohesion. Involved in the regulation of histone mRNA levels. May mediate mitotic chromosome condensation.
messages: Component of the TRAMP5 complex composed of at least AIR1, MTR4 and TFR5. Interacts with POL2, DPB2 and DPB11.
messages: Present with 2240 molecules/cell in log phase SD medium.
messages: Was originally thought to have DNA polymerase activity.
messages: nucleolus

559292:YGL045W
gene id: 559292:YGL045W
uniprot id: P53179
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the arrestin family. PalF/RIM8 subfamily.
messages: Expressed under acidic conditions and repressed by the processed, active form of RIM101 under alkaline conditions.
messages: Present with 784 molecules/cell in log phase SD medium.
messages: Required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH, which is necessary for sporulation and invasive growth.

559292:YDR365C
gene id: 559292:YDR365C
uniprot id: Q06344
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ESF1 family.
messages: Interacts with KRR1, NOP1, NSR1, PUF6 and UTP22, proteins involved in 18S rRNA synthesis. Interacts also with ribosomal proteins RPS1, RPS3, RPS4, RPS6, RPS11, RPL2, RPL3, RPL4, RPL7, RPL10, RPL20 and RPP0 as well as with the snoRNAs U3 and U14.
messages: Involved in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.
messages: Present with 656 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YOL104C
gene id: 559292:YOL104C
uniprot id: Q12366
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: During meiosis.
messages: Interacts with MPS3.
messages: Nucleus
messages: Required for telomeric clustering (bouquet stage) during meiosis 1 prophase, formation and efficient homolog pairing, meiosis 1 disjunction, and telomere deletion during meiosis. Promotes also meiotic recombination.
messages: telomere

559292:YKR008W
gene id: 559292:YKR008W
uniprot id: Q02206
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.
messages: Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
messages: Nucleus
messages: Present with 8570 molecules/cell in log phase SD medium.

559292:YBR247C
gene id: 559292:YBR247C
uniprot id: P38333
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bystin family.
messages: Cytoplasm
messages: Present with 21600 molecules/cell in log phase SD medium.
messages: Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunit shifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein.
messages: nucleolus

559292:YNL142W
gene id: 559292:YNL142W
uniprot id: P41948
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Impairs filamentation induction.
messages: Phosphorylated at Ser-457 by the TORC1 effector kinase NPR1 under nitrogen-limiting conditions which causes a conformational change in the C-terminal region (CTR) to form an open active conformation (PubMed:24476960, PubMed:27088325). Supplementation of nitrogen source leads to inactivation and instant Ser-457 dephosphorylation via plasma membrane PSR1 and PSR2 redundant phosphatases (PubMed:24476960).
messages: The residue Asn-4 of the protein's N-terminal tail is the only site that is glycosylated.
messages: Transporter for ammonium (both charged and uncharged NH3 and NH4) to use as a nitrogen source (PubMed:11069679, PubMed:11486013, PubMed:9234685, PubMed:9482721, PubMed:16477434, PubMed:18434596, PubMed:24476960, PubMed:27088325). The affinity of MEP2 is about twenty times higher than that of MEP1 (PubMed:9482721). MEP3 has the lowest affinity (PubMed:9482721). Under ammonium limitation acts as an ammonium sensor, generating a signal that leads to pseudohyphal (filamentous) growth (PubMed:9482721, PubMed:11069679, PubMed:16477434, PubMed:18434596, PubMed:32069286).
messages: Within the cytoplasmic CTD, an enhancer domain, limited to residues 428-441, upregulates substrate translocation via the MEP2 hydrophobic core, while an autoinhibitory domain, comprised within the 450-485 region and including the NPR1-target serine Ser-457, counteracts the action of the enhancer domain (PubMed:32069286). In between, a linker domain, limited to residues 442-449, appears required for optimal activity when the kinase is present but dispensable when the kinase integrity is altered (PubMed:32069286).

559292:YDR374C
gene id: 559292:YDR374C
uniprot id: Q06390
names: Developmental Stage
names: Disruption Phenotype
names: Function
messages: Defects in meiotic progression.
messages: Expressed in a meiosis-specific manner.
messages: RNA-binding protein that acts as a post-transcriptional regulator of phosphate metabolism by binding to the 3'-UTR region of PHO4 mRNA, decreasing its stability (PubMed:24206186). Acts by recognizing and binding N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (PubMed:24269006, PubMed:26318451).

559292:YPL247C
gene id: 559292:YPL247C
uniprot id: Q12523
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR68 family.
messages: Cytoplasm
messages: Nucleus
messages: Present with 799 molecules/cell in log phase SD medium.

559292:YKL095W
gene id: 559292:YKL095W
uniprot id: P28320
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron (PubMed:19935684, PubMed:27445308, PubMed:27459055, PubMed:29146871). Interacts (via C-terminus) with CLF1 (PubMed:23438600). Interacts (via N-terminus) with SYF1 (PubMed:23438600). Interacts with U2 snRNA; this interaction is direct (PubMed:23438600). Identified in the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2 (PubMed:11884590).
messages: Expressed in exponential-phase cells grown in rich medium.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:19935684, PubMed:27445308, PubMed:27459055, PubMed:29146871). Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (PubMed:23438600, PubMed:27459055). Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation (PubMed:29146871).
messages: Present with 2250 molecules/cell in log phase SD medium.

559292:YGR177C
gene id: 559292:YGR177C
uniprot id: P53296
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATF1 alcohol acetyltransferase family.
messages: Can use acetyl-CoA to synthesize acetate esters from various alcohols, producing ethyl acetate, isoamyl acetate, isobutyl acetate, butyl acetate, hexyl acetate, heptyl acetate and octyl acetate (PubMed:12957907, PubMed:12937998, PubMed:16845703, PubMed:17891501). ATF2 seems to play only a minor role in the acetate ester synthesis, compared to ATF1 (PubMed:12957907). Plays an active role in the detoxification hydroxysteroids and possibly certain phytochemicals, in association with the efflux pumps PDR5 and SNQ2 (PubMed:10103065).
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Present with 3000 molecules/cell in log phase SD medium.
messages: Results in an 18% decrease in isoamyl acetate formation and causes a 13% reduction of ethyl acetate formation (PubMed:12957907). Leads to the complete elimination of acetyl-CoA:pregnenolone acetyltransferase activity and consequently abolishes the esterification of pregnenolone and increases the toxicity of pregnenolone (PubMed:10103065).
messages: Segments of the N- and C-terminal domains (residues 19-36 and 515-532, respectively) are predicted to be amphipathic helices and are essential for endoplasmic reticulum membrane association (PubMed:25093817).

559292:YMR003W
gene id: 559292:YMR003W
uniprot id: Q03673
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM34 family.
messages: Increases frequency of mitochondrial genome loss.
messages: Mitochondrion membrane
messages: Present with 2820 molecules/cell in log phase SD medium.

559292:YBL054W
gene id: 559292:YBL054W
uniprot id: P34219
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DOT6 family.
messages: Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. TOD6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif.
messages: Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, DOT6, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, TOD6; UME1 and UME6.
messages: Cytoplasm
messages: Nucleus
messages: Present with 830 molecules/cell in log phase SD medium.

559292:YGR155W
gene id: 559292:YGR155W
uniprot id: P32582
names: Miscellaneous
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Present with 41900 molecules/cell in log phase SD medium.

559292:YLR157C
gene id: 559292:YLR157C
uniprot id: P0CX77
uniprot id: P0CX78
uniprot id: P0CX79
uniprot id: P0CZ17
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asparaginase 1 family.
messages: Periplasm
messages: Secreted
messages: Subject to nitrogen catabolite repression (NCR). Not found in cells grown on rich nitrogen sources like ammonia, glutamine or glutamate, but is found in cells that have been subjected to nitrogen starvation or have been grown on a poor nitrogen source such as proline.
messages: There are 4 copies for L-asparaginase 2 in yeast. The 4 identical copies ASP3-1, ASP3-2, ASP3-3 and ASP3-4 are arranged in tandem repeats located near a ribosomal DNA cluster.
messages: Yeast contains 2 L-asparaginase isoenzymes: cytoplasmic L-asparaginase I, and cell wall L-asparaginase II.

559292:YOR103C
gene id: 559292:YOR103C
uniprot id: P46964
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:8175708, PubMed:16297388, PubMed:16096345, PubMed:15831493, PubMed:15886282, PubMed:9405463, PubMed:29301962). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5, subcomplex 2 contains STT3, OST3, and OST4, and subcomplex 3 contains OST2, WBP1, and SWP1 (PubMed:29301962). Interacts with SEC61 and SSS1 (PubMed:15831493).
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

559292:YNL272C
gene id: 559292:YNL272C
uniprot id: P17065
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC2 family.
messages: Bud neck
messages: Bud tip
messages: Guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP. Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis. Binds the Rab GTPase YPT32, but does not have exchange activity on YPT32.
messages: Interacts with SEC4. Interacts with YPT32, preferentially in its GTP-bound form.
messages: Present with 13200 molecules/cell in log phase SD medium.
messages: The N-terminal domain (1-374) is sufficient for the exchange factor activity.
messages: secretory vesicle

559292:YMR100W
gene id: 559292:YMR100W
uniprot id: Q03162
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MUB1/samB family.
messages: Cytoplasm
messages: Interacts with UBR2 and RPN4.
messages: Involved in the determination of the onset of polarized growth. Required for the ubiquitin-dependent degradation of RPN4. Cooperates with UBR2 to transfer ubiquitin from RAD6 to RPN4.
messages: Is a short-lived protein whose degradation is dependent on the UBR2/RAD6 ubiquitin-protein ligase.
messages: Present with 125 molecules/cell in log phase SD medium.
messages: The MYND-type zinc finger is essential for the ubiquitin-dependent degradation of RPN4.

559292:YMR045C
gene id: 559292:YMR045C
uniprot id: Q04214
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
messages: Cytoplasm
messages: Initially, virus-like particles (VLPs) are composed of the structural unprocessed proteins Gag and Gag-Pol, and also contain the host initiator methionine tRNA (tRNA(i)-Met) which serves as a primer for minus-strand DNA synthesis, and a dimer of genomic Ty RNA. Processing of the polyproteins occurs within the particle and proceeds by an ordered pathway, called maturation. First, the protease (PR) is released by autocatalytic cleavage of the Gag-Pol polyprotein yielding capsid protein p45 and a Pol-p154 precursor protein. This cleavage is a prerequisite for subsequent processing of Pol-p154 at the remaining sites to release the mature structural and catalytic proteins. Maturation takes place prior to the RT reaction and is required to produce transposition-competent VLPs (By similarity).
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
messages: Integrase core domain contains the D-x(n)-D-x(35)-E motif, named for the phylogenetically conserved glutamic acid and aspartic acid residues and the invariant 35 amino acid spacing between the second and third acidic residues. Each acidic residue of the D,D(35)E motif is independently essential for the 3'-processing and strand transfer activities of purified integrase protein (By similarity).
messages: Nucleus
messages: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YMR046C ORF.
messages: Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).
messages: The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.
messages: The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.
messages: The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues (By similarity).

559292:YER025W
gene id: 559292:YER025W
uniprot id: P32481
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Eukaryotic translation initiation factor 2 (eIF-2) is a heterotrimeric G-protein composed of an alpha, a beta and a gamma subunit. The factors eIF-1, eIF-1A, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.
messages: Present with 20800 molecules/cell in log phase SD medium.

559292:YJL154C
gene id: 559292:YJL154C
uniprot id: P34110
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS35 family.
messages: Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPS29, VPS26 and VPS35.
messages: Membrane
messages: Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Vacuolar carboxypeptidase Y (CPY) sorting is completely dependent on the presence of functional VPS35. The latter may play a role in the function, modification or packaging of a CPY-specific receptor complex. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection.
messages: Present with 2360 molecules/cell in log phase SD medium.

559292:YBR052C
gene id: 559292:YBR052C
uniprot id: P38234
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WrbA family.
messages: Cytoplasm
messages: Membrane raft
messages: Present with 7060 molecules/cell in log phase SD medium.

559292:YFL058W
gene id: 559292:YFL058W
uniprot id: P43534
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

559292:YER029C
gene id: 559292:YER029C
uniprot id: P40018
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP SmB/SmN family.
messages: C-terminal extension may function as a nuclear localization signal (NLS).
messages: Component of the Sm core complex, present in spliceosomal snRNP U1, U2, U4/U6 and U5. The core complex contains SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively), and is probably a heptameric ring structure. SMB1 specifically interacts with SMD3. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Interacts with the trimethylguanosine synthase TGS1.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: Present with 861 molecules/cell in log phase SD medium.

559292:YOR006C
gene id: 559292:YOR006C
uniprot id: Q12094
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA (PubMed:27084949). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (PubMed:27084949). Required for processing 35S pre-rRNA at site D (PubMed:19806183).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Minor growth defect caused by late 18S rRNA processing defects, leading to a ribosomal subunit imbalance with a reduced 40S to 60S ratio.
messages: Nucleus
messages: Present with 3610 molecules/cell in log phase SD medium.

559292:YFL001W
gene id: 559292:YFL001W
uniprot id: P31115
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridines at positions 38 and 39 in the anticodon stem and loop of transfer RNAs.
messages: Nucleus
messages: Present with 5860 molecules/cell in log phase SD medium.

559292:YDL075W
gene id: 559292:YDL075W
uniprot id: P0C2H8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: There are 2 genes for eL31 in yeast.

559292:YER007W
gene id: 559292:YER007W
uniprot id: P39937
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Present with 2140 molecules/cell in log phase SD medium.
messages: Required for viability in the absence of the kinesin-related CIN8 mitotic motor. Seems to be involved in the assembly of alpha-tubulin.
messages: cytoskeleton

559292:YLR340W
gene id: 559292:YLR340W
uniprot id: P05317
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A. uL10 directly interacts with 28S rRNA (PubMed:16573688). uL10 interacts with YFL034W (PubMed:15286401).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.
messages: Cytoplasm

559292:YNL038W
gene id: 559292:YNL038W
uniprot id: P53961
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIGH family.
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

559292:YCL026C-B
gene id: 559292:YCL026C-B
uniprot id: Q96VH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nitroreductase family.
messages: Cytoplasm
messages: Nucleus

559292:YLR147C
gene id: 559292:YLR147C
uniprot id: P43321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Component of the Sm core complex, present in spliceosomal snRNP U1, U2, U4/U6 and U5. The core complex contains SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively), and is probably a heptameric ring structure. SMD3 specifically interacts with SMB1. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Also binds telomerase RNA and is required for its accumulation.
messages: cytosol

559292:YPR167C
gene id: 559292:YPR167C
uniprot id: P18408
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Present with 217 molecules/cell in log phase SD medium.
messages: The NADP dependent reduction of PAPS into sulfite involves thioredoxin which probably plays the role of a thiol carrier.

559292:YDR420W
gene id: 559292:YDR420W
uniprot id: P41809
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HKR1/MSB2 family.
messages: Cell membrane
messages: Could be O-glycosylated in the serine/threonine-rich domain.
messages: Expression is highly increased during spheroplast regeneration.
messages: Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. May regulate beta-glucan synthesis. Overexpression provides resistance to HM-1 killer toxin.

559292:YKR060W
gene id: 559292:YKR060W
uniprot id: P36144
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family. Highly divergent.
messages: Component of the 90S pre-ribosomes. Interacts with FAF1.
messages: Involved in rRNA-processing and ribosome biosynthesis.
messages: Present with 3060 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YDR004W
gene id: 559292:YDR004W
uniprot id: P25301
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Nucleus
messages: Participates in the repair of X-ray-induced damage to DNA and in meiosis. It may act in part by stabilizing a repair complex of other RAD genes.
messages: Present with 238 molecules/cell in log phase SD medium.

559292:YML016C
gene id: 559292:YML016C
uniprot id: P26570
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Essential for the maintenance of cell size and integrity in response to osmotic stress.
messages: Inhibited by the regulatory subunits VHS3 and SIS2.
messages: Interacts with SIS2 and VHS3, which regulate its activity.
messages: Present with 217 molecules/cell in log phase SD medium.
messages: Was originally thought to originate from a rabbit cDNA library and was known as protein phosphatase Z (PP-Z).

559292:YHR199C-A
gene id: 559292:YHR199C-A
uniprot id: Q3E7Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the borealin family.
messages: Component of the aurora kinase complex composed of at least BIR1, BNL1, IPL1 and SLI15.
messages: Component of the aurora kinase complex, also called chromosomal passenger complex (CPC), essential for chromosome segregation and metaphase chromosome alignment. Mediates the SLI15-BIR1 interaction within the CPC.
messages: Nucleus
messages: spindle

559292:YDR086C
gene id: 559292:YDR086C
uniprot id: P35179
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the heterotrimeric Sec61 complex, which is composed of SSH1, SBH1 and SSS1. Presumably three to four Sec61 heterotrimers assemble into an oligomeric ring with a central aqueous pore. In cotranslational ER import, the pore diameter varies from 9-15 A in a ribosome-free resting state to 40-60 A in a functional state when associated with the ribosome. The Sec61 complex is part of a channel-forming translocon complex whose composition seem to change dependent upon different functional states. During post-translational ER import the Sec61 complex associates with the Sec62/63 complex to form the Sec complex. SSH1 is a component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1. SSS1 interacts with OST1, OST4, SWP1 and WBP1, components of the OT complex.
messages: Endoplasmic reticulum membrane
messages: Part of the Sec61 complex, which is the major component of channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. Also part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein ER import.

559292:YMR250W
gene id: 559292:YMR250W
uniprot id: Q04792
names: Miscellaneous
names: Similarity
messages: Belongs to the group II decarboxylase family.
messages: Present with 1200 molecules/cell in log phase SD medium.

559292:YOL159C-A
gene id: 559292:YOL159C-A
uniprot id: Q3E769
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Present with 125 molecules/cell in log phase SD medium.

559292:YGL170C
gene id: 559292:YGL170C
uniprot id: P45819
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with itself. Interacts with MPC54, NUD1 and SPO21/MPC70.
messages: Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. Probable component of a core structural unit of the scaffold that initiates synthesis of the prospore membrane.
messages: Meiosis-specific.
messages: spindle pole body

559292:YFR048W
gene id: 559292:YFR048W
uniprot id: P43620
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMD1/sif2 family.
messages: Membrane
messages: Present with 656 molecules/cell in log phase SD medium.
messages: Required for sporulation.

559292:YCR075W-A
gene id: 559292:YCR075W-A
uniprot id: Q3E830
names: Disruption Phenotype
messages: Sensitive to high hydrostatic pressure (mechanical stress).

559292:YBR121C
gene id: 559292:YBR121C
uniprot id: P38088
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:23816885). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (By similarity).
messages: Cytoplasm
messages: GRS1, which appears to be a duplication of GRS2, is necessary and sufficient for both mitochondrial and cytoplasmic glycyl-tRNA synthetase activities, suggesting that GRS2 may not be essential.
messages: Homodimer.
messages: Mitochondrion matrix
messages: Present with 98400 molecules/cell in log phase SD medium.
messages: Produced by alternative initiation at an upstream UUG codon in-frame of the first AUG used for isoform Cytoplasmic.

559292:YIL134C-A
gene id: 559292:YIL134C-A
uniprot id: Q45U18
names: Subcellular Location Annotation
messages: Membrane

559292:YBL061C
gene id: 559292:YBL061C
uniprot id: P34226
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator of the chitin synthase CHS3 which polymerizes chitin, a structural polymer of the fungal cell wall.
messages: Belongs to the SKT5 family.
messages: Cell membrane
messages: Decreases CHS3 chitin synthase activity (PubMed:9234668). Decreases cellular chitin level (PubMed:9234668). Resistance to Calcofluor White (cell wall stressor) (PubMed:9234668). Normal CHS3 RNA level (PubMed:9234668). Decreases conjugation frequency (PubMed:9234668).
messages: Farnesylation is required for chitin synthase CHS3 activity but is not required for SKT5 membrane association.
messages: Induced by Calcofluor White (PubMed:9234668). Repressed by alpha-factor (PubMed:9234668). Unchanged during sporulation (PubMed:9234668).
messages: It is uncertain whether Met-1 or Met-15 is the initiator.
messages: May interact with CHS3 and seems to be an adapter (along with BNI4) to link CHS3 to septins.
messages: Present with 2580 molecules/cell in log phase SD medium.

559292:YAL059W
gene id: 559292:YAL059W
uniprot id: P39715
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle and the nucleopore complex.
messages: Belongs to the ECM1 family.
messages: Cytoplasm
messages: Nucleus
messages: Pre-ribosomal factor involved in 60S ribosomal protein subunit export from the nucleus.
messages: Present with 2840 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YLR263W
gene id: 559292:YLR263W
uniprot id: P14291
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Meiosis-specific.
messages: Nucleus
messages: Probable constituent of the synaptonemal complex during meiosis. May interact with HOP1. Required for meiosis I chromosome segregation.

559292:YMR200W
gene id: 559292:YMR200W
uniprot id: Q03691
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROT1 family.
messages: Endoplasmic reticulum membrane
messages: N-glycosylated.
messages: Present with 2360 molecules/cell in log phase SD medium.
messages: Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies. Controls actin cytoskeleton polarization to the mother-bud neck and CLB2 protein stability.

559292:YNL323W
gene id: 559292:YNL323W
uniprot id: P42838
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Involved in the asymmetrical organization of phosphatidylethanolamine in the plasma membrane.
messages: Monomer.
messages: Present with 2460 molecules/cell in log phase SD medium.

559292:YKR042W
gene id: 559292:YKR042W
uniprot id: P36135
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUN family.
messages: Induced by hydrogen peroxide. Repressed by superoxide radicals and anoxia.
messages: Involved in aging, oxidative stress response, and in the regulation of mitochondrial biogenesis. Inactivation of UTH1 increases life span, leads to higher resistance to heat stress and against hydrogen peroxide, and increases sensitivity to the superoxide radical-generating drug paraquat and to copper. Also required for the selective autophagic degradation of mitochondria (mitophagy) in response to nitrogen starvation. Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation. Involved in cell sensitivity to boric acid.
messages: Leads to increased resistance to zymolyase treatment and to boric acid.
messages: Mitochondrion outer membrane
messages: Present with 56900 molecules/cell in log phase SD medium.
messages: cell wall

559292:YPL210C
gene id: 559292:YPL210C
uniprot id: P38688
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP72 family.
messages: Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14 (PubMed:7925282). At least SRP14, SRP21, SRP68 and SRP72 are proposed to get assembled together with scR1 RNA as a pre-SRP complex in the nucleolus which is exported to the cytoplasm (PubMed:7925282).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:7925282, PubMed:10921896). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:10921896, PubMed:7925282). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds signal recognition particle RNA (7SL RNA) in presence of SRP68 (By similarity). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (PubMed:10921896).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Present with 11800 molecules/cell in log phase SD medium.
messages: nucleolus

559292:YOR059C
gene id: 559292:YOR059C
uniprot id: Q08448
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the putative lipase ROG1 family.
messages: Expression is up-regulated by the transcription factor RPN4.
messages: Leads to an altered morphology of lipid droplets with a smaller size.
messages: Lipid droplet
messages: Membrane
messages: Phospholipase involved in maintaining the lipid droplet morphology (PubMed:25014274). Has phospholipase activity with broad substrate specificity, acting on glycerophospholipids phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidycholine (PC) and phosphatidylserine (PS), primarily at sn-2 position (PubMed:25014274). It can later remove fatty acids from the sn-1 position of the produced lysophospholipids such as lysophosphatidylethanolamine (LPE) (PubMed:25014274). Shows also activity toward phosphatidylglycerol, but, in contrast to what was observed with the other phospholipids tested, prefers the sn-1 position (PubMed:25014274).
messages: Present with 1210 molecules/cell in log phase SD medium.

559292:YPL111W
gene id: 559292:YPL111W
uniprot id: P00812
names: Cofactor
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: By arginine or homoarginine.
messages: Homotrimer.
messages: Present with 42800 molecules/cell in log phase SD medium.

559292:YBR197C
gene id: 559292:YBR197C
uniprot id: P38306
names: Miscellaneous
messages: Present with 1360 molecules/cell in log phase SD medium.

559292:YHR141C
gene id: 559292:YHR141C
uniprot id: P0CX27
uniprot id: P0CX28
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: In wild-type cells, 78% of L42 is monomethylated at both Lys-40 and Lys-55, and 22% are a mixture of species with either residue monomethylated.
messages: Present with 13600 molecules/cell in log phase SD medium.
messages: Present with 3890 molecules/cell in log phase SD medium.
messages: There are 2 genes for eL42 in yeast.