553174:HMPREF0659 RS11670
gene id: 553174:HMPREF0659_RS11670
uniprot id: D9RXA1
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS06090
gene id: 553174:HMPREF0659_RS06090
uniprot id: D9RSN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

553174:HMPREF0659 RS08255
gene id: 553174:HMPREF0659_RS08255
uniprot id: D9RVF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

553174:HMPREF0659 RS04400
gene id: 553174:HMPREF0659_RS04400
uniprot id: D9RS51
names: Similarity
messages: Belongs to the CarB family.

553174:HMPREF0659 RS01745
gene id: 553174:HMPREF0659_RS01745
uniprot id: D9RTN5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

553174:HMPREF0659 RS08190
gene id: 553174:HMPREF0659_RS08190
uniprot id: D9RVE4
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS11855
gene id: 553174:HMPREF0659_RS11855
uniprot id: D9RXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

553174:HMPREF0659 RS03345
gene id: 553174:HMPREF0659_RS03345
uniprot id: D9RU61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

553174:HMPREF0659 RS02750
gene id: 553174:HMPREF0659_RS02750
uniprot id: D9RRM3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS05890
gene id: 553174:HMPREF0659_RS05890
uniprot id: D9RSJ9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

553174:HMPREF0659 RS09875
gene id: 553174:HMPREF0659_RS09875
uniprot id: D9RWC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

553174:HMPREF0659 RS09020
gene id: 553174:HMPREF0659_RS09020
uniprot id: D9RVV5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

553174:HMPREF0659 RS00205
gene id: 553174:HMPREF0659_RS00205
uniprot id: D9RR02
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS07495
gene id: 553174:HMPREF0659_RS07495
uniprot id: D9RV13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

553174:HMPREF0659 RS01015
gene id: 553174:HMPREF0659_RS01015
uniprot id: D9RRG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

553174:HMPREF0659 RS00465
gene id: 553174:HMPREF0659_RS00465
uniprot id: D9RR53
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS08860
gene id: 553174:HMPREF0659_RS08860
uniprot id: D9RVS5
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

553174:HMPREF0659 RS05155
gene id: 553174:HMPREF0659_RS05155
uniprot id: D9RUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

553174:HMPREF0659 RS03260
gene id: 553174:HMPREF0659_RS03260
uniprot id: D9RU44
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

553174:HMPREF0659 RS02470
gene id: 553174:HMPREF0659_RS02470
uniprot id: D9RU24
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

553174:HMPREF0659 RS01030
gene id: 553174:HMPREF0659_RS01030
uniprot id: D9RRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

553174:HMPREF0659 RS01510
gene id: 553174:HMPREF0659_RS01510
uniprot id: D9RTI9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

553174:HMPREF0659 RS08610
gene id: 553174:HMPREF0659_RS08610
uniprot id: D9RVM6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

553174:HMPREF0659 RS05210
gene id: 553174:HMPREF0659_RS05210
uniprot id: D9RUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

553174:HMPREF0659 RS09715
gene id: 553174:HMPREF0659_RS09715
uniprot id: D9RW95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

553174:HMPREF0659 RS09625
gene id: 553174:HMPREF0659_RS09625
uniprot id: D9RW74
names: Similarity
messages: Belongs to the fabD family.

553174:HMPREF0659 RS08850
gene id: 553174:HMPREF0659_RS08850
uniprot id: D9RVS3
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

553174:HMPREF0659 RS03010
gene id: 553174:HMPREF0659_RS03010
uniprot id: D9RRS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

553174:HMPREF0659 RS02160
gene id: 553174:HMPREF0659_RS02160
uniprot id: D9RTW3
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

553174:HMPREF0659 RS10405
gene id: 553174:HMPREF0659_RS10405
uniprot id: D9RWM3
names: Similarity
messages: Belongs to the type IA topoisomerase family.

553174:HMPREF0659 RS08665
gene id: 553174:HMPREF0659_RS08665
uniprot id: D9RVN7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

553174:HMPREF0659 RS08710
gene id: 553174:HMPREF0659_RS08710
uniprot id: D9RVP5
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

553174:HMPREF0659 RS05720
gene id: 553174:HMPREF0659_RS05720
uniprot id: D9RSH0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS03900
gene id: 553174:HMPREF0659_RS03900
uniprot id: D9RRW0
names: Similarity
messages: Belongs to the type IA topoisomerase family.

553174:HMPREF0659 RS01170
gene id: 553174:HMPREF0659_RS01170
uniprot id: D9RTD5
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS05920
gene id: 553174:HMPREF0659_RS05920
uniprot id: D9RSK5
names: Similarity
messages: Belongs to the Dps family.

553174:HMPREF0659 RS02175
gene id: 553174:HMPREF0659_RS02175
uniprot id: D9RTW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

553174:HMPREF0659 RS01640
gene id: 553174:HMPREF0659_RS01640
uniprot id: D9RTL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

553174:HMPREF0659 RS00975
gene id: 553174:HMPREF0659_RS00975
uniprot id: D9RRF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

553174:HMPREF0659 RS00470
gene id: 553174:HMPREF0659_RS00470
uniprot id: D9RR54
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

553174:HMPREF0659 RS05330
gene id: 553174:HMPREF0659_RS05330
uniprot id: D9RS93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

553174:HMPREF0659 RS02425
gene id: 553174:HMPREF0659_RS02425
uniprot id: D9RU15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

553174:HMPREF0659 RS01735
gene id: 553174:HMPREF0659_RS01735
uniprot id: D9RTN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

553174:HMPREF0659 RS10010
gene id: 553174:HMPREF0659_RS10010
uniprot id: D9RWF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

553174:HMPREF0659 RS06310
gene id: 553174:HMPREF0659_RS06310
uniprot id: D9RSS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

553174:HMPREF0659 RS08275
gene id: 553174:HMPREF0659_RS08275
uniprot id: D9RVG0
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS06165
gene id: 553174:HMPREF0659_RS06165
uniprot id: D9RSP8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

553174:HMPREF0659 RS05365
gene id: 553174:HMPREF0659_RS05365
uniprot id: D9RSA0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

553174:HMPREF0659 RS05270
gene id: 553174:HMPREF0659_RS05270
uniprot id: D9RS84
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS01150
gene id: 553174:HMPREF0659_RS01150
uniprot id: D9RTD2
names: Similarity
messages: Belongs to the peptidase M13 family.

553174:HMPREF0659 RS07135
gene id: 553174:HMPREF0659_RS07135
uniprot id: D9RUT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

553174:HMPREF0659 RS06900
gene id: 553174:HMPREF0659_RS06900
uniprot id: D9RT37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

553174:HMPREF0659 RS01620
gene id: 553174:HMPREF0659_RS01620
uniprot id: D9RTL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

553174:HMPREF0659 RS02375
gene id: 553174:HMPREF0659_RS02375
uniprot id: D9RU06
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

553174:HMPREF0659 RS00890
gene id: 553174:HMPREF0659_RS00890
uniprot id: D9RRD6
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

553174:HMPREF0659 RS05935
gene id: 553174:HMPREF0659_RS05935
uniprot id: D9RSK8
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

553174:HMPREF0659 RS02700
gene id: 553174:HMPREF0659_RS02700
uniprot id: D9RRL4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

553174:HMPREF0659 RS02105
gene id: 553174:HMPREF0659_RS02105
uniprot id: D9RTV2
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

553174:HMPREF0659 RS00735
gene id: 553174:HMPREF0659_RS00735
uniprot id: D9RRA6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

553174:HMPREF0659 RS00120
gene id: 553174:HMPREF0659_RS00120
uniprot id: D9RTA4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

553174:HMPREF0659 RS07200
gene id: 553174:HMPREF0659_RS07200
uniprot id: D9RUV4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer.

553174:HMPREF0659 RS04245
gene id: 553174:HMPREF0659_RS04245
uniprot id: D9RS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS05225
gene id: 553174:HMPREF0659_RS05225
uniprot id: D9RUT5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

553174:HMPREF0659 RS09330
gene id: 553174:HMPREF0659_RS09330
uniprot id: D9RW15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

553174:HMPREF0659 RS05985
gene id: 553174:HMPREF0659_RS05985
uniprot id: D9RSL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

553174:HMPREF0659 RS06820
gene id: 553174:HMPREF0659_RS06820
uniprot id: D9RT21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS00570
gene id: 553174:HMPREF0659_RS00570
uniprot id: D9RR73
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS04300
gene id: 553174:HMPREF0659_RS04300
uniprot id: D9RS32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

553174:HMPREF0659 RS06185
gene id: 553174:HMPREF0659_RS06185
uniprot id: D9RSQ1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

553174:HMPREF0659 RS03865
gene id: 553174:HMPREF0659_RS03865
uniprot id: D9RRV3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS01075
gene id: 553174:HMPREF0659_RS01075
uniprot id: D9RRH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

553174:HMPREF0659 RS12210
gene id: 553174:HMPREF0659_RS12210
uniprot id: D9RXJ2
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

553174:HMPREF0659 RS02330
gene id: 553174:HMPREF0659_RS02330
uniprot id: D9RTZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS12220
gene id: 553174:HMPREF0659_RS12220
uniprot id: D9RXJ4
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

553174:HMPREF0659 RS08330
gene id: 553174:HMPREF0659_RS08330
uniprot id: D9RVH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

553174:HMPREF0659 RS04415
gene id: 553174:HMPREF0659_RS04415
uniprot id: D9RS54
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS03930
gene id: 553174:HMPREF0659_RS03930
uniprot id: D9RRW6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

553174:HMPREF0659 RS11480
gene id: 553174:HMPREF0659_RS11480
uniprot id: D9RX69
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS01695
gene id: 553174:HMPREF0659_RS01695
uniprot id: D9RTM5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

553174:HMPREF0659 RS11375
gene id: 553174:HMPREF0659_RS11375
uniprot id: D9RX50
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

553174:HMPREF0659 RS04935
gene id: 553174:HMPREF0659_RS04935
uniprot id: D9RUN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

553174:HMPREF0659 RS01350
gene id: 553174:HMPREF0659_RS01350
uniprot id: D9RTG4
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

553174:HMPREF0659 RS00885
gene id: 553174:HMPREF0659_RS00885
uniprot id: D9RRD5
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

553174:HMPREF0659 RS07790
gene id: 553174:HMPREF0659_RS07790
uniprot id: D9RV69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS04855
gene id: 553174:HMPREF0659_RS04855
uniprot id: D9RUM0
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

553174:HMPREF0659 RS00690
gene id: 553174:HMPREF0659_RS00690
uniprot id: D9RR98
names: Caution
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS07280
gene id: 553174:HMPREF0659_RS07280
uniprot id: D9RUX0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

553174:HMPREF0659 RS04950
gene id: 553174:HMPREF0659_RS04950
uniprot id: D9RUN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

553174:HMPREF0659 RS03980
gene id: 553174:HMPREF0659_RS03980
uniprot id: D9RRX7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS01830
gene id: 553174:HMPREF0659_RS01830
uniprot id: D9RTP8
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

553174:HMPREF0659 RS09100
gene id: 553174:HMPREF0659_RS09100
uniprot id: D9RVX0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS02060
gene id: 553174:HMPREF0659_RS02060
uniprot id: D9RTU3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

553174:HMPREF0659 RS10935
gene id: 553174:HMPREF0659_RS10935
uniprot id: D9RWW6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

553174:HMPREF0659 RS01070
gene id: 553174:HMPREF0659_RS01070
uniprot id: D9RRH1
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS04840
gene id: 553174:HMPREF0659_RS04840
uniprot id: D9RUL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

553174:HMPREF0659 RS07475
gene id: 553174:HMPREF0659_RS07475
uniprot id: D9RV09
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

553174:HMPREF0659 RS03950
gene id: 553174:HMPREF0659_RS03950
uniprot id: D9RRX0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

553174:HMPREF0659 RS08405
gene id: 553174:HMPREF0659_RS08405
uniprot id: D9RVI6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

553174:HMPREF0659 RS02575
gene id: 553174:HMPREF0659_RS02575
uniprot id: D9RRJ0
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

553174:HMPREF0659 RS08155
gene id: 553174:HMPREF0659_RS08155
uniprot id: D9RVD8
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

553174:HMPREF0659 RS05125
gene id: 553174:HMPREF0659_RS05125
uniprot id: D9RUR6
names: Subcellular Location Annotation
messages: Cytoplasm

553174:HMPREF0659 RS01610
gene id: 553174:HMPREF0659_RS01610
uniprot id: D9RTK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

553174:HMPREF0659 RS02130
gene id: 553174:HMPREF0659_RS02130
uniprot id: D9RTV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

553174:HMPREF0659 RS05990
gene id: 553174:HMPREF0659_RS05990
uniprot id: D9RSL9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

553174:HMPREF0659 RS09310
gene id: 553174:HMPREF0659_RS09310
uniprot id: D9RW11
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

553174:HMPREF0659 RS09560
gene id: 553174:HMPREF0659_RS09560
uniprot id: D9RW61
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

553174:HMPREF0659 RS07965
gene id: 553174:HMPREF0659_RS07965
uniprot id: D9RVA2
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS06960
gene id: 553174:HMPREF0659_RS06960
uniprot id: D9RT48
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

553174:HMPREF0659 RS04715
gene id: 553174:HMPREF0659_RS04715
uniprot id: D9RUJ4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

553174:HMPREF0659 RS05995
gene id: 553174:HMPREF0659_RS05995
uniprot id: D9RSM0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

553174:HMPREF0659 RS09375
gene id: 553174:HMPREF0659_RS09375
uniprot id: D9RW24
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS08245
gene id: 553174:HMPREF0659_RS08245
uniprot id: D9RVF4
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS01120
gene id: 553174:HMPREF0659_RS01120
uniprot id: D9RTC6
names: Similarity
messages: Belongs to the glutamine synthetase family.

553174:HMPREF0659 RS02075
gene id: 553174:HMPREF0659_RS02075
uniprot id: D9RTU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

553174:HMPREF0659 RS07570
gene id: 553174:HMPREF0659_RS07570
uniprot id: D9RV27
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

553174:HMPREF0659 RS04460
gene id: 553174:HMPREF0659_RS04460
uniprot id: D9RS64
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

553174:HMPREF0659 RS01675
gene id: 553174:HMPREF0659_RS01675
uniprot id: D9RTM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

553174:HMPREF0659 RS08300
gene id: 553174:HMPREF0659_RS08300
uniprot id: D9RVG5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS08615
gene id: 553174:HMPREF0659_RS08615
uniprot id: D9RVM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

553174:HMPREF0659 RS08960
gene id: 553174:HMPREF0659_RS08960
uniprot id: D9RVU3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

553174:HMPREF0659 RS12095
gene id: 553174:HMPREF0659_RS12095
uniprot id: D9RXH1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

553174:HMPREF0659 RS00830
gene id: 553174:HMPREF0659_RS00830
uniprot id: D9RRC5
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

553174:HMPREF0659 RS03815
gene id: 553174:HMPREF0659_RS03815
uniprot id: D9RUF1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

553174:HMPREF0659 RS05585
gene id: 553174:HMPREF0659_RS05585
uniprot id: D9RSE4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

553174:HMPREF0659 RS08025
gene id: 553174:HMPREF0659_RS08025
uniprot id: D9RVB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

553174:HMPREF0659 RS07565
gene id: 553174:HMPREF0659_RS07565
uniprot id: D9RV26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

553174:HMPREF0659 RS08050
gene id: 553174:HMPREF0659_RS08050
uniprot id: D9RVB8
names: Similarity
messages: Belongs to the peptidase C69 family.

553174:HMPREF0659 RS04190
gene id: 553174:HMPREF0659_RS04190
uniprot id: D9RS17
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

553174:HMPREF0659 RS00405
gene id: 553174:HMPREF0659_RS00405
uniprot id: D9RR41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

553174:HMPREF0659 RS00295
gene id: 553174:HMPREF0659_RS00295
uniprot id: D9RR19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

553174:HMPREF0659 RS11380
gene id: 553174:HMPREF0659_RS11380
uniprot id: D9RX51
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

553174:HMPREF0659 RS02645
gene id: 553174:HMPREF0659_RS02645
uniprot id: D9RRK3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

553174:HMPREF0659 RS01460
gene id: 553174:HMPREF0659_RS01460
uniprot id: D9RTI4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

553174:HMPREF0659 RS08475
gene id: 553174:HMPREF0659_RS08475
uniprot id: D9RVK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS08285
gene id: 553174:HMPREF0659_RS08285
uniprot id: D9RVG2
names: Similarity
messages: Belongs to the asparaginase 1 family.

553174:HMPREF0659 RS03340
gene id: 553174:HMPREF0659_RS03340
uniprot id: D9RU60
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

553174:HMPREF0659 RS08650
gene id: 553174:HMPREF0659_RS08650
uniprot id: D9RVN4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

553174:HMPREF0659 RS09705
gene id: 553174:HMPREF0659_RS09705
uniprot id: D9RW93
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

553174:HMPREF0659 RS08875
gene id: 553174:HMPREF0659_RS08875
uniprot id: D9RVS8
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

553174:HMPREF0659 RS09915
gene id: 553174:HMPREF0659_RS09915
uniprot id: D9RWD6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS00680
gene id: 553174:HMPREF0659_RS00680
uniprot id: D9RR96
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

553174:HMPREF0659 RS11900
gene id: 553174:HMPREF0659_RS11900
uniprot id: D9RXE2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS06505
gene id: 553174:HMPREF0659_RS06505
uniprot id: D9RSW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

553174:HMPREF0659 RS05220
gene id: 553174:HMPREF0659_RS05220
uniprot id: D9RUT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

553174:HMPREF0659 RS03370
gene id: 553174:HMPREF0659_RS03370
uniprot id: D9RU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

553174:HMPREF0659 RS05245
gene id: 553174:HMPREF0659_RS05245
uniprot id: D9RUT8
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

553174:HMPREF0659 RS07775
gene id: 553174:HMPREF0659_RS07775
uniprot id: D9RV66
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

553174:HMPREF0659 RS05095
gene id: 553174:HMPREF0659_RS05095
uniprot id: D9RUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

553174:HMPREF0659 RS09280
gene id: 553174:HMPREF0659_RS09280
uniprot id: D9RW05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

553174:HMPREF0659 RS03365
gene id: 553174:HMPREF0659_RS03365
uniprot id: D9RU65
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS03920
gene id: 553174:HMPREF0659_RS03920
uniprot id: D9RRW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

553174:HMPREF0659 RS08745
gene id: 553174:HMPREF0659_RS08745
uniprot id: D9RVQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

553174:HMPREF0659 RS08695
gene id: 553174:HMPREF0659_RS08695
uniprot id: D9RVP2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

553174:HMPREF0659 RS01685
gene id: 553174:HMPREF0659_RS01685
uniprot id: D9RTM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

553174:HMPREF0659 RS06975
gene id: 553174:HMPREF0659_RS06975
uniprot id: D9RT51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

553174:HMPREF0659 RS01815
gene id: 553174:HMPREF0659_RS01815
uniprot id: D9RTP5
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

553174:HMPREF0659 RS11050
gene id: 553174:HMPREF0659_RS11050
uniprot id: D9RWY8
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS08020
gene id: 553174:HMPREF0659_RS08020
uniprot id: D9RVB2
names: Similarity
messages: Belongs to the serpin family.

553174:HMPREF0659 RS03375
gene id: 553174:HMPREF0659_RS03375
uniprot id: D9RU67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

553174:HMPREF0659 RS08225
gene id: 553174:HMPREF0659_RS08225
uniprot id: D9RVF1
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

553174:HMPREF0659 RS02740
gene id: 553174:HMPREF0659_RS02740
uniprot id: D9RRM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

553174:HMPREF0659 RS01060
gene id: 553174:HMPREF0659_RS01060
uniprot id: D9RRG9
names: Subcellular Location Annotation
messages: Cytoplasm

553174:HMPREF0659 RS02955
gene id: 553174:HMPREF0659_RS02955
uniprot id: D9RRR5
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

553174:HMPREF0659 RS04690
gene id: 553174:HMPREF0659_RS04690
uniprot id: D9RUI9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

553174:HMPREF0659 RS07955
gene id: 553174:HMPREF0659_RS07955
uniprot id: D9RVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

553174:HMPREF0659 RS08390
gene id: 553174:HMPREF0659_RS08390
uniprot id: D9RVI3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

553174:HMPREF0659 RS00915
gene id: 553174:HMPREF0659_RS00915
uniprot id: D9RRE1
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS03245
gene id: 553174:HMPREF0659_RS03245
uniprot id: D9RU41
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

553174:HMPREF0659 RS11535
gene id: 553174:HMPREF0659_RS11535
uniprot id: D9RX79
names: Subcellular Location Annotation
messages: cytosol

553174:HMPREF0659 RS08350
gene id: 553174:HMPREF0659_RS08350
uniprot id: D9RVH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS02530
gene id: 553174:HMPREF0659_RS02530
uniprot id: D9RRI2
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS04595
gene id: 553174:HMPREF0659_RS04595
uniprot id: D9RUG8
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

553174:HMPREF0659 RS00370
gene id: 553174:HMPREF0659_RS00370
uniprot id: D9RR34
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

553174:HMPREF0659 RS02085
gene id: 553174:HMPREF0659_RS02085
uniprot id: D9RTU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

553174:HMPREF0659 RS09460
gene id: 553174:HMPREF0659_RS09460
uniprot id: D9RW40
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

553174:HMPREF0659 RS04235
gene id: 553174:HMPREF0659_RS04235
uniprot id: D9RS25
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

553174:HMPREF0659 RS09670
gene id: 553174:HMPREF0659_RS09670
uniprot id: D9RW85
names: Similarity
messages: Belongs to the CapA family.

553174:HMPREF0659 RS02790
gene id: 553174:HMPREF0659_RS02790
uniprot id: D9RRN2
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

553174:HMPREF0659 RS09780
gene id: 553174:HMPREF0659_RS09780
uniprot id: D9RWA9
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

553174:HMPREF0659 RS09605
gene id: 553174:HMPREF0659_RS09605
uniprot id: D9RW70
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

553174:HMPREF0659 RS09240
gene id: 553174:HMPREF0659_RS09240
uniprot id: D9RVZ7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

553174:HMPREF0659 RS03800
gene id: 553174:HMPREF0659_RS03800
uniprot id: D9RUE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

553174:HMPREF0659 RS02715
gene id: 553174:HMPREF0659_RS02715
uniprot id: D9RRL7
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS06065
gene id: 553174:HMPREF0659_RS06065
uniprot id: D9RSM8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

553174:HMPREF0659 RS05800
gene id: 553174:HMPREF0659_RS05800
uniprot id: D9RSI2
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

553174:HMPREF0659 RS05240
gene id: 553174:HMPREF0659_RS05240
uniprot id: D9RUT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS10695
gene id: 553174:HMPREF0659_RS10695
uniprot id: D9RWS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

553174:HMPREF0659 RS04315
gene id: 553174:HMPREF0659_RS04315
uniprot id: D9RS35
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

553174:HMPREF0659 RS07560
gene id: 553174:HMPREF0659_RS07560
uniprot id: D9RV25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

553174:HMPREF0659 RS05420
gene id: 553174:HMPREF0659_RS05420
uniprot id: D9RSB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS00060
gene id: 553174:HMPREF0659_RS00060
uniprot id: D9RT92
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

553174:HMPREF0659 RS08900
gene id: 553174:HMPREF0659_RS08900
uniprot id: D9RVT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

553174:HMPREF0659 RS09110
gene id: 553174:HMPREF0659_RS09110
uniprot id: D9RVX2
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

553174:HMPREF0659 RS02200
gene id: 553174:HMPREF0659_RS02200
uniprot id: D9RTX2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

553174:HMPREF0659 RS10095
gene id: 553174:HMPREF0659_RS10095
uniprot id: D9RWH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

553174:HMPREF0659 RS09810
gene id: 553174:HMPREF0659_RS09810
uniprot id: D9RWB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

553174:HMPREF0659 RS10875
gene id: 553174:HMPREF0659_RS10875
uniprot id: D9RWV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS02635
gene id: 553174:HMPREF0659_RS02635
uniprot id: D9RRK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS08880
gene id: 553174:HMPREF0659_RS08880
uniprot id: D9RVS9
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

553174:HMPREF0659 RS07705
gene id: 553174:HMPREF0659_RS07705
uniprot id: D9RV52
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

553174:HMPREF0659 RS02070
gene id: 553174:HMPREF0659_RS02070
uniprot id: D9RTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

553174:HMPREF0659 RS07550
gene id: 553174:HMPREF0659_RS07550
uniprot id: D9RV23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

553174:HMPREF0659 RS09040
gene id: 553174:HMPREF0659_RS09040
uniprot id: D9RVV9
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS02430
gene id: 553174:HMPREF0659_RS02430
uniprot id: D9RU16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

553174:HMPREF0659 RS04380
gene id: 553174:HMPREF0659_RS04380
uniprot id: D9RS47
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

553174:HMPREF0659 RS07915
gene id: 553174:HMPREF0659_RS07915
uniprot id: D9RV92
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

553174:HMPREF0659 RS11650
gene id: 553174:HMPREF0659_RS11650
uniprot id: D9RX97
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

553174:HMPREF0659 RS02675
gene id: 553174:HMPREF0659_RS02675
uniprot id: D9RRK9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

553174:HMPREF0659 RS09265
gene id: 553174:HMPREF0659_RS09265
uniprot id: D9RW02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

553174:HMPREF0659 RS06320
gene id: 553174:HMPREF0659_RS06320
uniprot id: D9RSS6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

553174:HMPREF0659 RS05550
gene id: 553174:HMPREF0659_RS05550
uniprot id: D9RSD7
names: Similarity
messages: Belongs to the peptidase S13 family.

553174:HMPREF0659 RS06085
gene id: 553174:HMPREF0659_RS06085
uniprot id: D9RSN2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

553174:HMPREF0659 RS03845
gene id: 553174:HMPREF0659_RS03845
uniprot id: D9RRU9
names: Similarity
messages: Belongs to the cytochrome c-552 family.

553174:HMPREF0659 RS08815
gene id: 553174:HMPREF0659_RS08815
uniprot id: D9RVR6
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

553174:HMPREF0659 RS01570
gene id: 553174:HMPREF0659_RS01570
uniprot id: D9RTK0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS04195
gene id: 553174:HMPREF0659_RS04195
uniprot id: D9RS18
names: Similarity
messages: Belongs to the peptidase S49 family.

553174:HMPREF0659 RS01630
gene id: 553174:HMPREF0659_RS01630
uniprot id: D9RTL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

553174:HMPREF0659 RS04385
gene id: 553174:HMPREF0659_RS04385
uniprot id: D9RS48
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

553174:HMPREF0659 RS00960
gene id: 553174:HMPREF0659_RS00960
uniprot id: D9RRF0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

553174:HMPREF0659 RS07545
gene id: 553174:HMPREF0659_RS07545
uniprot id: D9RV22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

553174:HMPREF0659 RS10905
gene id: 553174:HMPREF0659_RS10905
uniprot id: D9RWW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS07390
gene id: 553174:HMPREF0659_RS07390
uniprot id: D9RUZ2
names: Similarity
messages: Belongs to the pyruvate kinase family.

553174:HMPREF0659 RS02120
gene id: 553174:HMPREF0659_RS02120
uniprot id: D9RTV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

553174:HMPREF0659 RS00600
gene id: 553174:HMPREF0659_RS00600
uniprot id: D9RR79
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

553174:HMPREF0659 RS02215
gene id: 553174:HMPREF0659_RS02215
uniprot id: D9RTX5
names: Similarity
messages: Belongs to the UPF0102 family.

553174:HMPREF0659 RS00350
gene id: 553174:HMPREF0659_RS00350
uniprot id: D9RR30
names: Similarity
messages: Belongs to the peptidase S26 family.

553174:HMPREF0659 RS06680
gene id: 553174:HMPREF0659_RS06680
uniprot id: D9RSZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS06865
gene id: 553174:HMPREF0659_RS06865
uniprot id: D9RT30
names: Similarity
messages: Belongs to the Skp family.

553174:HMPREF0659 RS02315
gene id: 553174:HMPREF0659_RS02315
uniprot id: D9RTZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

553174:HMPREF0659 RS09585
gene id: 553174:HMPREF0659_RS09585
uniprot id: D9RW66
names: Similarity
messages: Belongs to the glutathione peroxidase family.

553174:HMPREF0659 RS04675
gene id: 553174:HMPREF0659_RS04675
uniprot id: D9RUI6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

553174:HMPREF0659 RS00300
gene id: 553174:HMPREF0659_RS00300
uniprot id: D9RR20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

553174:HMPREF0659 RS02270
gene id: 553174:HMPREF0659_RS02270
uniprot id: D9RTY6
names: Similarity
messages: Belongs to the thioredoxin family.

553174:HMPREF0659 RS06665
gene id: 553174:HMPREF0659_RS06665
uniprot id: D9RSZ2
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS06110
gene id: 553174:HMPREF0659_RS06110
uniprot id: D9RSN7
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS06575
gene id: 553174:HMPREF0659_RS06575
uniprot id: D9RSX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

553174:HMPREF0659 RS09505
gene id: 553174:HMPREF0659_RS09505
uniprot id: D9RW50
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

553174:HMPREF0659 RS05445
gene id: 553174:HMPREF0659_RS05445
uniprot id: D9RSB6
names: Similarity
messages: Belongs to the peptidase M16 family.

553174:HMPREF0659 RS04615
gene id: 553174:HMPREF0659_RS04615
uniprot id: D9RUH2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

553174:HMPREF0659 RS07845
gene id: 553174:HMPREF0659_RS07845
uniprot id: D9RV80
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

553174:HMPREF0659 RS05180
gene id: 553174:HMPREF0659_RS05180
uniprot id: D9RUS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

553174:HMPREF0659 RS03080
gene id: 553174:HMPREF0659_RS03080
uniprot id: D9RRT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

553174:HMPREF0659 RS01665
gene id: 553174:HMPREF0659_RS01665
uniprot id: D9RTL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

553174:HMPREF0659 RS05410
gene id: 553174:HMPREF0659_RS05410
uniprot id: D9RSA9
names: Similarity
messages: Belongs to the transglycosylase Slt family.

553174:HMPREF0659 RS11750
gene id: 553174:HMPREF0659_RS11750
uniprot id: D9RXB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

553174:HMPREF0659 RS00025
gene id: 553174:HMPREF0659_RS00025
uniprot id: D9RT85
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

553174:HMPREF0659 RS00750
gene id: 553174:HMPREF0659_RS00750
uniprot id: D9RRB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS00555
gene id: 553174:HMPREF0659_RS00555
uniprot id: D9RR70
names: Similarity
messages: Belongs to the LOG family.

553174:HMPREF0659 RS04620
gene id: 553174:HMPREF0659_RS04620
uniprot id: D9RUH3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

553174:HMPREF0659 RS06855
gene id: 553174:HMPREF0659_RS06855
uniprot id: D9RT28
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

553174:HMPREF0659 RS02565
gene id: 553174:HMPREF0659_RS02565
uniprot id: D9RRI8
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS10655
gene id: 553174:HMPREF0659_RS10655
uniprot id: D9RWR7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

553174:HMPREF0659 RS10660
gene id: 553174:HMPREF0659_RS10660
uniprot id: D9RWR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

553174:HMPREF0659 RS06570
gene id: 553174:HMPREF0659_RS06570
uniprot id: D9RSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell inner membrane
messages: Membrane
messages: Transport of potassium into the cell.

553174:HMPREF0659 RS08620
gene id: 553174:HMPREF0659_RS08620
uniprot id: D9RVM8
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

553174:HMPREF0659 RS06195
gene id: 553174:HMPREF0659_RS06195
uniprot id: D9RSQ3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

553174:HMPREF0659 RS00290
gene id: 553174:HMPREF0659_RS00290
uniprot id: D9RR18
names: Similarity
messages: Belongs to the peptidase S41A family.

553174:HMPREF0659 RS00085
gene id: 553174:HMPREF0659_RS00085
uniprot id: D9RT97
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

553174:HMPREF0659 RS09970
gene id: 553174:HMPREF0659_RS09970
uniprot id: D9RWE7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

553174:HMPREF0659 RS01960
gene id: 553174:HMPREF0659_RS01960
uniprot id: D9RTS4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

553174:HMPREF0659 RS12205
gene id: 553174:HMPREF0659_RS12205
uniprot id: D9RXJ1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

553174:HMPREF0659 RS11070
gene id: 553174:HMPREF0659_RS11070
uniprot id: D9RWZ2
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

553174:HMPREF0659 RS05415
gene id: 553174:HMPREF0659_RS05415
uniprot id: D9RSB0
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

553174:HMPREF0659 RS03405
gene id: 553174:HMPREF0659_RS03405
uniprot id: D9RU73
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS02760
gene id: 553174:HMPREF0659_RS02760
uniprot id: D9RRM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

553174:HMPREF0659 RS11735
gene id: 553174:HMPREF0659_RS11735
uniprot id: D9RXB3
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

553174:HMPREF0659 RS04210
gene id: 553174:HMPREF0659_RS04210
uniprot id: D9RS21
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

553174:HMPREF0659 RS05515
gene id: 553174:HMPREF0659_RS05515
uniprot id: D9RSD0
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

553174:HMPREF0659 RS10005
gene id: 553174:HMPREF0659_RS10005
uniprot id: D9RWF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

553174:HMPREF0659 RS00590
gene id: 553174:HMPREF0659_RS00590
uniprot id: D9RR77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

553174:HMPREF0659 RS06810
gene id: 553174:HMPREF0659_RS06810
uniprot id: D9RT19
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

553174:HMPREF0659 RS07070
gene id: 553174:HMPREF0659_RS07070
uniprot id: D9RT71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

553174:HMPREF0659 RS07515
gene id: 553174:HMPREF0659_RS07515
uniprot id: D9RV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

553174:HMPREF0659 RS03840
gene id: 553174:HMPREF0659_RS03840
uniprot id: D9RUF6
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS01275
gene id: 553174:HMPREF0659_RS01275
uniprot id: D9RTF4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

553174:HMPREF0659 RS02285
gene id: 553174:HMPREF0659_RS02285
uniprot id: D9RTY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

553174:HMPREF0659 RS07780
gene id: 553174:HMPREF0659_RS07780
uniprot id: D9RV67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

553174:HMPREF0659 RS01950
gene id: 553174:HMPREF0659_RS01950
uniprot id: D9RTS2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS09995
gene id: 553174:HMPREF0659_RS09995
uniprot id: D9RWF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

553174:HMPREF0659 RS10715
gene id: 553174:HMPREF0659_RS10715
uniprot id: D9RWS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

553174:HMPREF0659 RS10640
gene id: 553174:HMPREF0659_RS10640
uniprot id: D9RWR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS03605
gene id: 553174:HMPREF0659_RS03605
uniprot id: D9RUB3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

553174:HMPREF0659 RS01065
gene id: 553174:HMPREF0659_RS01065
uniprot id: D9RRH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS07425
gene id: 553174:HMPREF0659_RS07425
uniprot id: D9RUZ8
names: Similarity
messages: Belongs to the aldose epimerase family.

553174:HMPREF0659 RS08590
gene id: 553174:HMPREF0659_RS08590
uniprot id: D9RVM2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS06740
gene id: 553174:HMPREF0659_RS06740
uniprot id: D9RT08
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS03795
gene id: 553174:HMPREF0659_RS03795
uniprot id: D9RUE7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

553174:HMPREF0659 RS00850
gene id: 553174:HMPREF0659_RS00850
uniprot id: D9RRC8
names: Similarity
messages: Belongs to the peptidase S41A family.

553174:HMPREF0659 RS02475
gene id: 553174:HMPREF0659_RS02475
uniprot id: D9RU25
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

553174:HMPREF0659 RS01010
gene id: 553174:HMPREF0659_RS01010
uniprot id: D9RRF9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

553174:HMPREF0659 RS06615
gene id: 553174:HMPREF0659_RS06615
uniprot id: D9RSY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS08445
gene id: 553174:HMPREF0659_RS08445
uniprot id: D9RVJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

553174:HMPREF0659 RS09185
gene id: 553174:HMPREF0659_RS09185
uniprot id: D9RVY6
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

553174:HMPREF0659 RS05090
gene id: 553174:HMPREF0659_RS05090
uniprot id: D9RUQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

553174:HMPREF0659 RS05165
gene id: 553174:HMPREF0659_RS05165
uniprot id: D9RUS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

553174:HMPREF0659 RS00430
gene id: 553174:HMPREF0659_RS00430
uniprot id: D9RR46
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

553174:HMPREF0659 RS07875
gene id: 553174:HMPREF0659_RS07875
uniprot id: D9RV85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS01085
gene id: 553174:HMPREF0659_RS01085
uniprot id: D9RRH4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS06120
gene id: 553174:HMPREF0659_RS06120
uniprot id: D9RSN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

553174:HMPREF0659 RS01100
gene id: 553174:HMPREF0659_RS01100
uniprot id: D9RTC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

553174:HMPREF0659 RS02560
gene id: 553174:HMPREF0659_RS02560
uniprot id: D9RRI7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

553174:HMPREF0659 RS05520
gene id: 553174:HMPREF0659_RS05520
uniprot id: D9RSD1
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

553174:HMPREF0659 RS06635
gene id: 553174:HMPREF0659_RS06635
uniprot id: D9RSY7
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS09025
gene id: 553174:HMPREF0659_RS09025
uniprot id: D9RVV6
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

553174:HMPREF0659 RS01775
gene id: 553174:HMPREF0659_RS01775
uniprot id: D9RTN9
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

553174:HMPREF0659 RS01625
gene id: 553174:HMPREF0659_RS01625
uniprot id: D9RTL1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

553174:HMPREF0659 RS09125
gene id: 553174:HMPREF0659_RS09125
uniprot id: D9RVX5
names: Similarity
messages: Belongs to the IMPACT family.

553174:HMPREF0659 RS06260
gene id: 553174:HMPREF0659_RS06260
uniprot id: D9RSR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

553174:HMPREF0659 RS07370
gene id: 553174:HMPREF0659_RS07370
uniprot id: D9RUY8
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

553174:HMPREF0659 RS03305
gene id: 553174:HMPREF0659_RS03305
uniprot id: D9RU53
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

553174:HMPREF0659 RS05465
gene id: 553174:HMPREF0659_RS05465
uniprot id: D9RSC0
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS07555
gene id: 553174:HMPREF0659_RS07555
uniprot id: D9RV24
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

553174:HMPREF0659 RS01655
gene id: 553174:HMPREF0659_RS01655
uniprot id: D9RTL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

553174:HMPREF0659 RS07645
gene id: 553174:HMPREF0659_RS07645
uniprot id: D9RV41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

553174:HMPREF0659 RS10920
gene id: 553174:HMPREF0659_RS10920
uniprot id: D9RWW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

553174:HMPREF0659 RS08070
gene id: 553174:HMPREF0659_RS08070
uniprot id: D9RVC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

553174:HMPREF0659 RS09070
gene id: 553174:HMPREF0659_RS09070
uniprot id: D9RVW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

553174:HMPREF0659 RS04045
gene id: 553174:HMPREF0659_RS04045
uniprot id: D9RRZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

553174:HMPREF0659 RS03835
gene id: 553174:HMPREF0659_RS03835
uniprot id: D9RUF5
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS04390
gene id: 553174:HMPREF0659_RS04390
uniprot id: D9RS49
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS02335
gene id: 553174:HMPREF0659_RS02335
uniprot id: D9RTZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS11385
gene id: 553174:HMPREF0659_RS11385
uniprot id: D9RX52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

553174:HMPREF0659 RS06880
gene id: 553174:HMPREF0659_RS06880
uniprot id: D9RT33
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

553174:HMPREF0659 RS12215
gene id: 553174:HMPREF0659_RS12215
uniprot id: D9RXJ3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

553174:HMPREF0659 RS08145
gene id: 553174:HMPREF0659_RS08145
uniprot id: D9RVD6
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

553174:HMPREF0659 RS00950
gene id: 553174:HMPREF0659_RS00950
uniprot id: D9RRE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

553174:HMPREF0659 RS09450
gene id: 553174:HMPREF0659_RS09450
uniprot id: D9RW39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

553174:HMPREF0659 RS05565
gene id: 553174:HMPREF0659_RS05565
uniprot id: D9RSE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

553174:HMPREF0659 RS08540
gene id: 553174:HMPREF0659_RS08540
uniprot id: D9RVL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

553174:HMPREF0659 RS08085
gene id: 553174:HMPREF0659_RS08085
uniprot id: D9RVC5
names: Similarity
messages: Belongs to the Fur family.

553174:HMPREF0659 RS11640
gene id: 553174:HMPREF0659_RS11640
uniprot id: D9RX95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

553174:HMPREF0659 RS02100
gene id: 553174:HMPREF0659_RS02100
uniprot id: D9RTV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

553174:HMPREF0659 RS08820
gene id: 553174:HMPREF0659_RS08820
uniprot id: D9RVR7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

553174:HMPREF0659 RS02695
gene id: 553174:HMPREF0659_RS02695
uniprot id: D9RRL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

553174:HMPREF0659 RS02385
gene id: 553174:HMPREF0659_RS02385
uniprot id: D9RU08
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

553174:HMPREF0659 RS07905
gene id: 553174:HMPREF0659_RS07905
uniprot id: D9RV90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

553174:HMPREF0659 RS09595
gene id: 553174:HMPREF0659_RS09595
uniprot id: D9RW68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

553174:HMPREF0659 RS08750
gene id: 553174:HMPREF0659_RS08750
uniprot id: D9RVQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

553174:HMPREF0659 RS11440
gene id: 553174:HMPREF0659_RS11440
uniprot id: D9RX62
names: Similarity
messages: Belongs to the Nudix hydrolase family.

553174:HMPREF0659 RS02275
gene id: 553174:HMPREF0659_RS02275
uniprot id: D9RTY7
names: Subcellular Location Annotation
messages: Cytoplasm

553174:HMPREF0659 RS01940
gene id: 553174:HMPREF0659_RS01940
uniprot id: D9RTS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

553174:HMPREF0659 RS05715
gene id: 553174:HMPREF0659_RS05715
uniprot id: D9RSG9
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS11530
gene id: 553174:HMPREF0659_RS11530
uniprot id: D9RX78
names: Subcellular Location Annotation
messages: cytosol

553174:HMPREF0659 RS09245
gene id: 553174:HMPREF0659_RS09245
uniprot id: D9RVZ8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

553174:HMPREF0659 RS09835
gene id: 553174:HMPREF0659_RS09835
uniprot id: D9RWC0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

553174:HMPREF0659 RS03970
gene id: 553174:HMPREF0659_RS03970
uniprot id: D9RRX5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS03915
gene id: 553174:HMPREF0659_RS03915
uniprot id: D9RRW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

553174:HMPREF0659 RS05320
gene id: 553174:HMPREF0659_RS05320
uniprot id: D9RS91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

553174:HMPREF0659 RS08500
gene id: 553174:HMPREF0659_RS08500
uniprot id: D9RVK5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

553174:HMPREF0659 RS09590
gene id: 553174:HMPREF0659_RS09590
uniprot id: D9RW67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

553174:HMPREF0659 RS00860
gene id: 553174:HMPREF0659_RS00860
uniprot id: D9RRD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

553174:HMPREF0659 RS08720
gene id: 553174:HMPREF0659_RS08720
uniprot id: D9RVP7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

553174:HMPREF0659 RS01080
gene id: 553174:HMPREF0659_RS01080
uniprot id: D9RRH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

553174:HMPREF0659 RS08925
gene id: 553174:HMPREF0659_RS08925
uniprot id: D9RVT8
names: Similarity
messages: Belongs to the Skp family.

553174:HMPREF0659 RS00145
gene id: 553174:HMPREF0659_RS00145
uniprot id: D9RTA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS07065
gene id: 553174:HMPREF0659_RS07065
uniprot id: D9RT70
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS04625
gene id: 553174:HMPREF0659_RS04625
uniprot id: D9RUH5
names: Similarity
messages: Belongs to the TrpF family.

553174:HMPREF0659 RS02770
gene id: 553174:HMPREF0659_RS02770
uniprot id: D9RRM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS04670
gene id: 553174:HMPREF0659_RS04670
uniprot id: D9RUI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

553174:HMPREF0659 RS09165
gene id: 553174:HMPREF0659_RS09165
uniprot id: D9RVY3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

553174:HMPREF0659 RS07540
gene id: 553174:HMPREF0659_RS07540
uniprot id: D9RV21
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS07465
gene id: 553174:HMPREF0659_RS07465
uniprot id: D9RV07
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS03320
gene id: 553174:HMPREF0659_RS03320
uniprot id: D9RU56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

553174:HMPREF0659 RS02055
gene id: 553174:HMPREF0659_RS02055
uniprot id: D9RTU2
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS05250
gene id: 553174:HMPREF0659_RS05250
uniprot id: D9RS80
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS08040
gene id: 553174:HMPREF0659_RS08040
uniprot id: D9RVB6
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

553174:HMPREF0659 RS00790
gene id: 553174:HMPREF0659_RS00790
uniprot id: D9RRB7
names: Similarity
messages: Belongs to the disproportionating enzyme family.

553174:HMPREF0659 RS09815
gene id: 553174:HMPREF0659_RS09815
uniprot id: D9RWB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

553174:HMPREF0659 RS05390
gene id: 553174:HMPREF0659_RS05390
uniprot id: D9RSA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

553174:HMPREF0659 RS05940
gene id: 553174:HMPREF0659_RS05940
uniprot id: D9RSK9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

553174:HMPREF0659 RS04850
gene id: 553174:HMPREF0659_RS04850
uniprot id: D9RUL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

553174:HMPREF0659 RS03070
gene id: 553174:HMPREF0659_RS03070
uniprot id: D9RRT2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

553174:HMPREF0659 RS06705
gene id: 553174:HMPREF0659_RS06705
uniprot id: D9RT00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

553174:HMPREF0659 RS07660
gene id: 553174:HMPREF0659_RS07660
uniprot id: D9RV44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

553174:HMPREF0659 RS08580
gene id: 553174:HMPREF0659_RS08580
uniprot id: D9RVM0
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS01710
gene id: 553174:HMPREF0659_RS01710
uniprot id: D9RTM8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

553174:HMPREF0659 RS06075
gene id: 553174:HMPREF0659_RS06075
uniprot id: D9RSN0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

553174:HMPREF0659 RS07415
gene id: 553174:HMPREF0659_RS07415
uniprot id: D9RUZ6
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

553174:HMPREF0659 RS00805
gene id: 553174:HMPREF0659_RS00805
uniprot id: D9RRC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS04805
gene id: 553174:HMPREF0659_RS04805
uniprot id: D9RUL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

553174:HMPREF0659 RS04355
gene id: 553174:HMPREF0659_RS04355
uniprot id: D9RS42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

553174:HMPREF0659 RS02040
gene id: 553174:HMPREF0659_RS02040
uniprot id: D9RTU0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

553174:HMPREF0659 RS09530
gene id: 553174:HMPREF0659_RS09530
uniprot id: D9RW55
names: Similarity
messages: Belongs to the phosphohexose mutase family.

553174:HMPREF0659 RS01690
gene id: 553174:HMPREF0659_RS01690
uniprot id: D9RTM4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

553174:HMPREF0659 RS09255
gene id: 553174:HMPREF0659_RS09255
uniprot id: D9RW00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

553174:HMPREF0659 RS01390
gene id: 553174:HMPREF0659_RS01390
uniprot id: D9RTH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

553174:HMPREF0659 RS09105
gene id: 553174:HMPREF0659_RS09105
uniprot id: D9RVX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS09500
gene id: 553174:HMPREF0659_RS09500
uniprot id: D9RW49
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

553174:HMPREF0659 RS01975
gene id: 553174:HMPREF0659_RS01975
uniprot id: D9RTS7
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

553174:HMPREF0659 RS04770
gene id: 553174:HMPREF0659_RS04770
uniprot id: D9RUK3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

553174:HMPREF0659 RS11285
gene id: 553174:HMPREF0659_RS11285
uniprot id: D9RX30
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

553174:HMPREF0659 RS05745
gene id: 553174:HMPREF0659_RS05745
uniprot id: D9RSH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS02985
gene id: 553174:HMPREF0659_RS02985
uniprot id: D9RRR9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

553174:HMPREF0659 RS01525
gene id: 553174:HMPREF0659_RS01525
uniprot id: D9RTJ2
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

553174:HMPREF0659 RS05635
gene id: 553174:HMPREF0659_RS05635
uniprot id: D9RSF3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

553174:HMPREF0659 RS04050
gene id: 553174:HMPREF0659_RS04050
uniprot id: D9RRZ2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

553174:HMPREF0659 RS02970
gene id: 553174:HMPREF0659_RS02970
uniprot id: D9RRR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS10995
gene id: 553174:HMPREF0659_RS10995
uniprot id: D9RWX8
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS00895
gene id: 553174:HMPREF0659_RS00895
uniprot id: D9RRD7
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

553174:HMPREF0659 RS09640
gene id: 553174:HMPREF0659_RS09640
uniprot id: D9RW79
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

553174:HMPREF0659 RS09135
gene id: 553174:HMPREF0659_RS09135
uniprot id: D9RVX7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

553174:HMPREF0659 RS09700
gene id: 553174:HMPREF0659_RS09700
uniprot id: D9RW92
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

553174:HMPREF0659 RS05385
gene id: 553174:HMPREF0659_RS05385
uniprot id: D9RSA4
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

553174:HMPREF0659 RS11665
gene id: 553174:HMPREF0659_RS11665
uniprot id: D9RXA0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

553174:HMPREF0659 RS06105
gene id: 553174:HMPREF0659_RS06105
uniprot id: D9RSN6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

553174:HMPREF0659 RS00185
gene id: 553174:HMPREF0659_RS00185
uniprot id: D9RTB7
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

553174:HMPREF0659 RS05725
gene id: 553174:HMPREF0659_RS05725
uniprot id: D9RSH1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

553174:HMPREF0659 RS04795
gene id: 553174:HMPREF0659_RS04795
uniprot id: D9RUK8
names: Similarity
messages: Belongs to the RecJ family.

553174:HMPREF0659 RS00050
gene id: 553174:HMPREF0659_RS00050
uniprot id: D9RT90
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

553174:HMPREF0659 RS05000
gene id: 553174:HMPREF0659_RS05000
uniprot id: D9RUP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

553174:HMPREF0659 RS07785
gene id: 553174:HMPREF0659_RS07785
uniprot id: D9RV68
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS06835
gene id: 553174:HMPREF0659_RS06835
uniprot id: D9RT24
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

553174:HMPREF0659 RS08220
gene id: 553174:HMPREF0659_RS08220
uniprot id: D9RVF0
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS11100
gene id: 553174:HMPREF0659_RS11100
uniprot id: D9RWZ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

553174:HMPREF0659 RS02005
gene id: 553174:HMPREF0659_RS02005
uniprot id: D9RTT3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

553174:HMPREF0659 RS06425
gene id: 553174:HMPREF0659_RS06425
uniprot id: D9RSU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS04125
gene id: 553174:HMPREF0659_RS04125
uniprot id: D9RS07
names: Similarity
messages: Belongs to the XseB family.

553174:HMPREF0659 RS06725
gene id: 553174:HMPREF0659_RS06725
uniprot id: D9RT04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

553174:HMPREF0659 RS03270
gene id: 553174:HMPREF0659_RS03270
uniprot id: D9RU46
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

553174:HMPREF0659 RS11010
gene id: 553174:HMPREF0659_RS11010
uniprot id: D9RWY1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

553174:HMPREF0659 RS05115
gene id: 553174:HMPREF0659_RS05115
uniprot id: D9RUR4
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS08035
gene id: 553174:HMPREF0659_RS08035
uniprot id: D9RVB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

553174:HMPREF0659 RS02730
gene id: 553174:HMPREF0659_RS02730
uniprot id: D9RRL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS03355
gene id: 553174:HMPREF0659_RS03355
uniprot id: D9RU63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

553174:HMPREF0659 RS06660
gene id: 553174:HMPREF0659_RS06660
uniprot id: D9RSZ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

553174:HMPREF0659 RS02340
gene id: 553174:HMPREF0659_RS02340
uniprot id: D9RTZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

553174:HMPREF0659 RS09140
gene id: 553174:HMPREF0659_RS09140
uniprot id: D9RVX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS00020
gene id: 553174:HMPREF0659_RS00020
uniprot id: D9RT84
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

553174:HMPREF0659 RS08565
gene id: 553174:HMPREF0659_RS08565
uniprot id: D9RVL7
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS08670
gene id: 553174:HMPREF0659_RS08670
uniprot id: D9RVN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

553174:HMPREF0659 RS06690
gene id: 553174:HMPREF0659_RS06690
uniprot id: D9RSZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

553174:HMPREF0659 RS10035
gene id: 553174:HMPREF0659_RS10035
uniprot id: D9RWG1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS05945
gene id: 553174:HMPREF0659_RS05945
uniprot id: D9RSL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

553174:HMPREF0659 RS06410
gene id: 553174:HMPREF0659_RS06410
uniprot id: D9RSU5
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

553174:HMPREF0659 RS05140
gene id: 553174:HMPREF0659_RS05140
uniprot id: D9RUR8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

553174:HMPREF0659 RS08630
gene id: 553174:HMPREF0659_RS08630
uniprot id: D9RVN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

553174:HMPREF0659 RS03415
gene id: 553174:HMPREF0659_RS03415
uniprot id: D9RU75
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

553174:HMPREF0659 RS01765
gene id: 553174:HMPREF0659_RS01765
uniprot id: D9RTN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS06510
gene id: 553174:HMPREF0659_RS06510
uniprot id: D9RSW4
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

553174:HMPREF0659 RS04120
gene id: 553174:HMPREF0659_RS04120
uniprot id: D9RS06
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

553174:HMPREF0659 RS03335
gene id: 553174:HMPREF0659_RS03335
uniprot id: D9RU59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

553174:HMPREF0659 RS04745
gene id: 553174:HMPREF0659_RS04745
uniprot id: D9RUK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

553174:HMPREF0659 RS07690
gene id: 553174:HMPREF0659_RS07690
uniprot id: D9RV49
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

553174:HMPREF0659 RS08780
gene id: 553174:HMPREF0659_RS08780
uniprot id: D9RVQ9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

553174:HMPREF0659 RS08170
gene id: 553174:HMPREF0659_RS08170
uniprot id: D9RVE1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

553174:HMPREF0659 RS07040
gene id: 553174:HMPREF0659_RS07040
uniprot id: D9RT64
names: Similarity
messages: Belongs to the SufE family.

553174:HMPREF0659 RS07680
gene id: 553174:HMPREF0659_RS07680
uniprot id: D9RV47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

553174:HMPREF0659 RS01810
gene id: 553174:HMPREF0659_RS01810
uniprot id: D9RTP4
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

553174:HMPREF0659 RS01615
gene id: 553174:HMPREF0659_RS01615
uniprot id: D9RTK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

553174:HMPREF0659 RS03855
gene id: 553174:HMPREF0659_RS03855
uniprot id: D9RRV1
names: Similarity
messages: Belongs to the Fur family.

553174:HMPREF0659 RS04085
gene id: 553174:HMPREF0659_RS04085
uniprot id: D9RRZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

553174:HMPREF0659 RS04540
gene id: 553174:HMPREF0659_RS04540
uniprot id: D9RUF7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

553174:HMPREF0659 RS00425
gene id: 553174:HMPREF0659_RS00425
uniprot id: D9RR45
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

553174:HMPREF0659 RS07490
gene id: 553174:HMPREF0659_RS07490
uniprot id: D9RV12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

553174:HMPREF0659 RS02990
gene id: 553174:HMPREF0659_RS02990
uniprot id: D9RRS0
names: Similarity
messages: Belongs to the DEAD box helicase family.

553174:HMPREF0659 RS07395
gene id: 553174:HMPREF0659_RS07395
uniprot id: D9RUZ3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

553174:HMPREF0659 RS08005
gene id: 553174:HMPREF0659_RS08005
uniprot id: D9RVA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

553174:HMPREF0659 RS08835
gene id: 553174:HMPREF0659_RS08835
uniprot id: D9RVS0
names: Similarity
messages: Belongs to the GARS family.

553174:HMPREF0659 RS05560
gene id: 553174:HMPREF0659_RS05560
uniprot id: D9RSD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.
messages: Homodimer.

553174:HMPREF0659 RS01455
gene id: 553174:HMPREF0659_RS01455
uniprot id: D9RTI3
names: Similarity
messages: Belongs to the peptidase M24B family.

553174:HMPREF0659 RS05740
gene id: 553174:HMPREF0659_RS05740
uniprot id: D9RSH4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

553174:HMPREF0659 RS06640
gene id: 553174:HMPREF0659_RS06640
uniprot id: D9RSY8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

553174:HMPREF0659 RS11030
gene id: 553174:HMPREF0659_RS11030
uniprot id: D9RWY5
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

553174:HMPREF0659 RS06920
gene id: 553174:HMPREF0659_RS06920
uniprot id: D9RT41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

553174:HMPREF0659 RS00395
gene id: 553174:HMPREF0659_RS00395
uniprot id: D9RR39
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

553174:HMPREF0659 RS04845
gene id: 553174:HMPREF0659_RS04845
uniprot id: D9RUL8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

553174:HMPREF0659 RS05625
gene id: 553174:HMPREF0659_RS05625
uniprot id: D9RSF2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

553174:HMPREF0659 RS04435
gene id: 553174:HMPREF0659_RS04435
uniprot id: D9RS59
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

553174:HMPREF0659 RS08680
gene id: 553174:HMPREF0659_RS08680
uniprot id: D9RVP0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS08685
gene id: 553174:HMPREF0659_RS08685
uniprot id: D9RVP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole

553174:HMPREF0659 RS00870
gene id: 553174:HMPREF0659_RS00870
uniprot id: D9RRD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

553174:HMPREF0659 RS05185
gene id: 553174:HMPREF0659_RS05185
uniprot id: D9RUS7
names: Similarity
messages: Belongs to the HSP15 family.

553174:HMPREF0659 RS02170
gene id: 553174:HMPREF0659_RS02170
uniprot id: D9RTW6
names: Cofactor
messages: Binds 1 zinc ion per subunit.

553174:HMPREF0659 RS01730
gene id: 553174:HMPREF0659_RS01730
uniprot id: D9RTN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

553174:HMPREF0659 RS09410
gene id: 553174:HMPREF0659_RS09410
uniprot id: D9RW31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

553174:HMPREF0659 RS07245
gene id: 553174:HMPREF0659_RS07245
uniprot id: D9RUW3
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

553174:HMPREF0659 RS01530
gene id: 553174:HMPREF0659_RS01530
uniprot id: D9RTJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

553174:HMPREF0659 RS00810
gene id: 553174:HMPREF0659_RS00810
uniprot id: D9RRC1
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS05620
gene id: 553174:HMPREF0659_RS05620
uniprot id: D9RSF1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

553174:HMPREF0659 RS05290
gene id: 553174:HMPREF0659_RS05290
uniprot id: D9RS88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

553174:HMPREF0659 RS03790
gene id: 553174:HMPREF0659_RS03790
uniprot id: D9RUE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

553174:HMPREF0659 RS02685
gene id: 553174:HMPREF0659_RS02685
uniprot id: D9RRL1
names: Similarity
messages: Belongs to the glutamine synthetase family.

553174:HMPREF0659 RS06355
gene id: 553174:HMPREF0659_RS06355
uniprot id: D9RST4
names: Similarity
messages: Belongs to the DprA/Smf family.

553174:HMPREF0659 RS01540
gene id: 553174:HMPREF0659_RS01540
uniprot id: D9RTJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

553174:HMPREF0659 RS02485
gene id: 553174:HMPREF0659_RS02485
uniprot id: D9RU27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

553174:HMPREF0659 RS10945
gene id: 553174:HMPREF0659_RS10945
uniprot id: D9RWW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

553174:HMPREF0659 RS07470
gene id: 553174:HMPREF0659_RS07470
uniprot id: D9RV08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

553174:HMPREF0659 RS00390
gene id: 553174:HMPREF0659_RS00390
uniprot id: D9RR38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS00335
gene id: 553174:HMPREF0659_RS00335
uniprot id: D9RR27
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

553174:HMPREF0659 RS01605
gene id: 553174:HMPREF0659_RS01605
uniprot id: D9RTK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

553174:HMPREF0659 RS09770
gene id: 553174:HMPREF0659_RS09770
uniprot id: D9RWA7
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS00045
gene id: 553174:HMPREF0659_RS00045
uniprot id: D9RT89
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

553174:HMPREF0659 RS04240
gene id: 553174:HMPREF0659_RS04240
uniprot id: D9RS26
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS05810
gene id: 553174:HMPREF0659_RS05810
uniprot id: D9RSI4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS11825
gene id: 553174:HMPREF0659_RS11825
uniprot id: D9RXC9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

553174:HMPREF0659 RS04990
gene id: 553174:HMPREF0659_RS04990
uniprot id: D9RUP0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

553174:HMPREF0659 RS06440
gene id: 553174:HMPREF0659_RS06440
uniprot id: D9RSV1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

553174:HMPREF0659 RS08625
gene id: 553174:HMPREF0659_RS08625
uniprot id: D9RVM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

553174:HMPREF0659 RS00480
gene id: 553174:HMPREF0659_RS00480
uniprot id: D9RR56
names: Similarity
messages: Belongs to the DEAD box helicase family.

553174:HMPREF0659 RS04790
gene id: 553174:HMPREF0659_RS04790
uniprot id: D9RUK7
names: Similarity
messages: Belongs to the peptidase C1 family.

553174:HMPREF0659 RS09850
gene id: 553174:HMPREF0659_RS09850
uniprot id: D9RWC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

553174:HMPREF0659 RS02455
gene id: 553174:HMPREF0659_RS02455
uniprot id: D9RU21
names: Similarity
messages: Belongs to the peptidase C10 family.

553174:HMPREF0659 RS02395
gene id: 553174:HMPREF0659_RS02395
uniprot id: D9RU10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

553174:HMPREF0659 RS02845
gene id: 553174:HMPREF0659_RS02845
uniprot id: D9RRP3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

553174:HMPREF0659 RS07910
gene id: 553174:HMPREF0659_RS07910
uniprot id: D9RV91
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

553174:HMPREF0659 RS06520
gene id: 553174:HMPREF0659_RS06520
uniprot id: D9RSW6
names: Similarity
messages: Belongs to the UPF0597 family.

553174:HMPREF0659 RS12185
gene id: 553174:HMPREF0659_RS12185
uniprot id: D9RXI6
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

553174:HMPREF0659 RS05460
gene id: 553174:HMPREF0659_RS05460
uniprot id: D9RSB9
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS09575
gene id: 553174:HMPREF0659_RS09575
uniprot id: D9RW64
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS06395
gene id: 553174:HMPREF0659_RS06395
uniprot id: D9RSU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

553174:HMPREF0659 RS00090
gene id: 553174:HMPREF0659_RS00090
uniprot id: D9RT98
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

553174:HMPREF0659 RS09415
gene id: 553174:HMPREF0659_RS09415
uniprot id: D9RW32
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS03020
gene id: 553174:HMPREF0659_RS03020
uniprot id: D9RRS6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

553174:HMPREF0659 RS09365
gene id: 553174:HMPREF0659_RS09365
uniprot id: D9RW22
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

553174:HMPREF0659 RS04725
gene id: 553174:HMPREF0659_RS04725
uniprot id: D9RUJ6
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS05400
gene id: 553174:HMPREF0659_RS05400
uniprot id: D9RSA7
names: Similarity
messages: Belongs to the ParB family.

553174:HMPREF0659 RS06985
gene id: 553174:HMPREF0659_RS06985
uniprot id: D9RT53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

553174:HMPREF0659 RS05805
gene id: 553174:HMPREF0659_RS05805
uniprot id: D9RSI3
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

553174:HMPREF0659 RS07400
gene id: 553174:HMPREF0659_RS07400
uniprot id: D9RUZ4
names: Similarity
messages: Belongs to the transketolase family.

553174:HMPREF0659 RS11140
gene id: 553174:HMPREF0659_RS11140
uniprot id: D9RX04
names: Similarity
messages: Belongs to the ribF family.

553174:HMPREF0659 RS02295
gene id: 553174:HMPREF0659_RS02295
uniprot id: D9RTZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

553174:HMPREF0659 RS04305
gene id: 553174:HMPREF0659_RS04305
uniprot id: D9RS33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

553174:HMPREF0659 RS01435
gene id: 553174:HMPREF0659_RS01435
uniprot id: D9RTH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS04900
gene id: 553174:HMPREF0659_RS04900
uniprot id: D9RUM6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

553174:HMPREF0659 RS08675
gene id: 553174:HMPREF0659_RS08675
uniprot id: D9RVN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

553174:HMPREF0659 RS01580
gene id: 553174:HMPREF0659_RS01580
uniprot id: D9RTK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS04600
gene id: 553174:HMPREF0659_RS04600
uniprot id: D9RUG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

553174:HMPREF0659 RS00705
gene id: 553174:HMPREF0659_RS00705
uniprot id: D9RRA1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

553174:HMPREF0659 RS08795
gene id: 553174:HMPREF0659_RS08795
uniprot id: D9RVR2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS01535
gene id: 553174:HMPREF0659_RS01535
uniprot id: D9RTJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

553174:HMPREF0659 RS03600
gene id: 553174:HMPREF0659_RS03600
uniprot id: D9RUB2
names: Similarity
messages: Belongs to the HsdR family.

553174:HMPREF0659 RS02445
gene id: 553174:HMPREF0659_RS02445
uniprot id: D9RU19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

553174:HMPREF0659 RS01600
gene id: 553174:HMPREF0659_RS01600
uniprot id: D9RTK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

553174:HMPREF0659 RS05175
gene id: 553174:HMPREF0659_RS05175
uniprot id: D9RUS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

553174:HMPREF0659 RS07710
gene id: 553174:HMPREF0659_RS07710
uniprot id: D9RV53
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS02415
gene id: 553174:HMPREF0659_RS02415
uniprot id: D9RU13
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

553174:HMPREF0659 RS00535
gene id: 553174:HMPREF0659_RS00535
uniprot id: D9RR66
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

553174:HMPREF0659 RS04115
gene id: 553174:HMPREF0659_RS04115
uniprot id: D9RS05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

553174:HMPREF0659 RS01660
gene id: 553174:HMPREF0659_RS01660
uniprot id: D9RTL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

553174:HMPREF0659 RS08895
gene id: 553174:HMPREF0659_RS08895
uniprot id: D9RVT2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

553174:HMPREF0659 RS07990
gene id: 553174:HMPREF0659_RS07990
uniprot id: D9RVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS06070
gene id: 553174:HMPREF0659_RS06070
uniprot id: D9RSM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

553174:HMPREF0659 RS00695
gene id: 553174:HMPREF0659_RS00695
uniprot id: D9RR99
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

553174:HMPREF0659 RS01280
gene id: 553174:HMPREF0659_RS01280
uniprot id: D9RTF5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS10665
gene id: 553174:HMPREF0659_RS10665
uniprot id: D9RWR9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

553174:HMPREF0659 RS09430
gene id: 553174:HMPREF0659_RS09430
uniprot id: D9RW35
names: Similarity
messages: Belongs to the UPF0246 family.

553174:HMPREF0659 RS09975
gene id: 553174:HMPREF0659_RS09975
uniprot id: D9RWE9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

553174:HMPREF0659 RS06515
gene id: 553174:HMPREF0659_RS06515
uniprot id: D9RSW5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

553174:HMPREF0659 RS09630
gene id: 553174:HMPREF0659_RS09630
uniprot id: D9RW76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

553174:HMPREF0659 RS09345
gene id: 553174:HMPREF0659_RS09345
uniprot id: D9RW18
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

553174:HMPREF0659 RS02450
gene id: 553174:HMPREF0659_RS02450
uniprot id: D9RU20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

553174:HMPREF0659 RS01585
gene id: 553174:HMPREF0659_RS01585
uniprot id: D9RTK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

553174:HMPREF0659 RS00945
gene id: 553174:HMPREF0659_RS00945
uniprot id: D9RRE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

553174:HMPREF0659 RS06860
gene id: 553174:HMPREF0659_RS06860
uniprot id: D9RT29
names: Similarity
messages: Belongs to the Skp family.

553174:HMPREF0659 RS02975
gene id: 553174:HMPREF0659_RS02975
uniprot id: D9RRR7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

553174:HMPREF0659 RS06735
gene id: 553174:HMPREF0659_RS06735
uniprot id: D9RT06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

553174:HMPREF0659 RS01025
gene id: 553174:HMPREF0659_RS01025
uniprot id: D9RRG2
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

553174:HMPREF0659 RS03000
gene id: 553174:HMPREF0659_RS03000
uniprot id: D9RRS2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS04565
gene id: 553174:HMPREF0659_RS04565
uniprot id: D9RUG2
names: Caution
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS03085
gene id: 553174:HMPREF0659_RS03085
uniprot id: D9RRT5
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

553174:HMPREF0659 RS02080
gene id: 553174:HMPREF0659_RS02080
uniprot id: D9RTU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

553174:HMPREF0659 RS03105
gene id: 553174:HMPREF0659_RS03105
uniprot id: D9RRT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

553174:HMPREF0659 RS00550
gene id: 553174:HMPREF0659_RS00550
uniprot id: D9RR69
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

553174:HMPREF0659 RS03995
gene id: 553174:HMPREF0659_RS03995
uniprot id: D9RRY0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

553174:HMPREF0659 RS04945
gene id: 553174:HMPREF0659_RS04945
uniprot id: D9RUN1
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS01845
gene id: 553174:HMPREF0659_RS01845
uniprot id: D9RTQ1
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS06245
gene id: 553174:HMPREF0659_RS06245
uniprot id: D9RSR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

553174:HMPREF0659 RS09250
gene id: 553174:HMPREF0659_RS09250
uniprot id: D9RVZ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

553174:HMPREF0659 RS10915
gene id: 553174:HMPREF0659_RS10915
uniprot id: D9RWW1
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS03330
gene id: 553174:HMPREF0659_RS03330
uniprot id: D9RU58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

553174:HMPREF0659 RS01295
gene id: 553174:HMPREF0659_RS01295
uniprot id: D9RTF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

553174:HMPREF0659 RS01450
gene id: 553174:HMPREF0659_RS01450
uniprot id: D9RTI2
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

553174:HMPREF0659 RS01465
gene id: 553174:HMPREF0659_RS01465
uniprot id: D9RTI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

553174:HMPREF0659 RS07620
gene id: 553174:HMPREF0659_RS07620
uniprot id: D9RV36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

553174:HMPREF0659 RS11870
gene id: 553174:HMPREF0659_RS11870
uniprot id: D9RXD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

553174:HMPREF0659 RS00595
gene id: 553174:HMPREF0659_RS00595
uniprot id: D9RR78
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

553174:HMPREF0659 RS05350
gene id: 553174:HMPREF0659_RS05350
uniprot id: D9RS97
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS09060
gene id: 553174:HMPREF0659_RS09060
uniprot id: D9RVW2
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

553174:HMPREF0659 RS08740
gene id: 553174:HMPREF0659_RS08740
uniprot id: D9RVQ1
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

553174:HMPREF0659 RS01405
gene id: 553174:HMPREF0659_RS01405
uniprot id: D9RTH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

553174:HMPREF0659 RS09735
gene id: 553174:HMPREF0659_RS09735
uniprot id: D9RW99
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS00995
gene id: 553174:HMPREF0659_RS00995
uniprot id: D9RRF6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

553174:HMPREF0659 RS12145
gene id: 553174:HMPREF0659_RS12145
uniprot id: D9RXI1
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS09740
gene id: 553174:HMPREF0659_RS09740
uniprot id: D9RWA0
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS09340
gene id: 553174:HMPREF0659_RS09340
uniprot id: D9RW17
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

553174:HMPREF0659 RS07240
gene id: 553174:HMPREF0659_RS07240
uniprot id: D9RUW2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

553174:HMPREF0659 RS01740
gene id: 553174:HMPREF0659_RS01740
uniprot id: D9RTN4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

553174:HMPREF0659 RS08905
gene id: 553174:HMPREF0659_RS08905
uniprot id: D9RVT4
names: Similarity
messages: Belongs to the heat shock protein 90 family.

553174:HMPREF0659 RS07880
gene id: 553174:HMPREF0659_RS07880
uniprot id: D9RV86
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

553174:HMPREF0659 RS08530
gene id: 553174:HMPREF0659_RS08530
uniprot id: D9RVL0
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS01005
gene id: 553174:HMPREF0659_RS01005
uniprot id: D9RRF8
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS06315
gene id: 553174:HMPREF0659_RS06315
uniprot id: D9RSS5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase H family.
messages: Binds 2 metal ions per subunit. Manganese or magnesium.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

553174:HMPREF0659 RS04545
gene id: 553174:HMPREF0659_RS04545
uniprot id: D9RUF8
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS08295
gene id: 553174:HMPREF0659_RS08295
uniprot id: D9RVG4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

553174:HMPREF0659 RS00130
gene id: 553174:HMPREF0659_RS00130
uniprot id: D9RTA6
names: Similarity
messages: Belongs to the sigma-54 factor family.

553174:HMPREF0659 RS01495
gene id: 553174:HMPREF0659_RS01495
uniprot id: D9RTI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

553174:HMPREF0659 RS03310
gene id: 553174:HMPREF0659_RS03310
uniprot id: D9RU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

553174:HMPREF0659 RS08965
gene id: 553174:HMPREF0659_RS08965
uniprot id: D9RVU4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

553174:HMPREF0659 RS01955
gene id: 553174:HMPREF0659_RS01955
uniprot id: D9RTS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

553174:HMPREF0659 RS03360
gene id: 553174:HMPREF0659_RS03360
uniprot id: D9RU64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

553174:HMPREF0659 RS08080
gene id: 553174:HMPREF0659_RS08080
uniprot id: D9RVC4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

553174:HMPREF0659 RS01650
gene id: 553174:HMPREF0659_RS01650
uniprot id: D9RTL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

553174:HMPREF0659 RS09880
gene id: 553174:HMPREF0659_RS09880
uniprot id: D9RWC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

553174:HMPREF0659 RS07500
gene id: 553174:HMPREF0659_RS07500
uniprot id: D9RV14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

553174:HMPREF0659 RS00785
gene id: 553174:HMPREF0659_RS00785
uniprot id: D9RRB6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

553174:HMPREF0659 RS02940
gene id: 553174:HMPREF0659_RS02940
uniprot id: D9RRR2
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS09805
gene id: 553174:HMPREF0659_RS09805
uniprot id: D9RWB3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

553174:HMPREF0659 RS01430
gene id: 553174:HMPREF0659_RS01430
uniprot id: D9RTH8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

553174:HMPREF0659 RS03480
gene id: 553174:HMPREF0659_RS03480
uniprot id: D9RU86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

553174:HMPREF0659 RS08760
gene id: 553174:HMPREF0659_RS08760
uniprot id: D9RVQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

553174:HMPREF0659 RS02125
gene id: 553174:HMPREF0659_RS02125
uniprot id: D9RTV6
names: Similarity
messages: Belongs to the MreC family.

553174:HMPREF0659 RS08770
gene id: 553174:HMPREF0659_RS08770
uniprot id: D9RVQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

553174:HMPREF0659 RS05865
gene id: 553174:HMPREF0659_RS05865
uniprot id: D9RSJ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS01515
gene id: 553174:HMPREF0659_RS01515
uniprot id: D9RTJ0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

553174:HMPREF0659 RS09765
gene id: 553174:HMPREF0659_RS09765
uniprot id: D9RWA6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

553174:HMPREF0659 RS06205
gene id: 553174:HMPREF0659_RS06205
uniprot id: D9RSQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

553174:HMPREF0659 RS07840
gene id: 553174:HMPREF0659_RS07840
uniprot id: D9RV79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

553174:HMPREF0659 RS04475
gene id: 553174:HMPREF0659_RS04475
uniprot id: D9RS67
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

553174:HMPREF0659 RS04130
gene id: 553174:HMPREF0659_RS04130
uniprot id: D9RS08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XseA family.
messages: Cytoplasm

553174:HMPREF0659 RS05020
gene id: 553174:HMPREF0659_RS05020
uniprot id: D9RUP6
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

553174:HMPREF0659 RS01635
gene id: 553174:HMPREF0659_RS01635
uniprot id: D9RTL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

553174:HMPREF0659 RS06190
gene id: 553174:HMPREF0659_RS06190
uniprot id: D9RSQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

553174:HMPREF0659 RS01020
gene id: 553174:HMPREF0659_RS01020
uniprot id: D9RRG1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

553174:HMPREF0659 RS02500
gene id: 553174:HMPREF0659_RS02500
uniprot id: D9RRH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS10740
gene id: 553174:HMPREF0659_RS10740
uniprot id: D9RWT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

553174:HMPREF0659 RS00190
gene id: 553174:HMPREF0659_RS00190
uniprot id: D9RTB8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

553174:HMPREF0659 RS00065
gene id: 553174:HMPREF0659_RS00065
uniprot id: D9RT93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

553174:HMPREF0659 RS01670
gene id: 553174:HMPREF0659_RS01670
uniprot id: D9RTM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

553174:HMPREF0659 RS09000
gene id: 553174:HMPREF0659_RS09000
uniprot id: D9RVV1
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

553174:HMPREF0659 RS05950
gene id: 553174:HMPREF0659_RS05950
uniprot id: D9RSL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

553174:HMPREF0659 RS00875
gene id: 553174:HMPREF0659_RS00875
uniprot id: D9RRD3
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

553174:HMPREF0659 RS11775
gene id: 553174:HMPREF0659_RS11775
uniprot id: D9RXC0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

553174:HMPREF0659 RS07505
gene id: 553174:HMPREF0659_RS07505
uniprot id: D9RV15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

553174:HMPREF0659 RS04095
gene id: 553174:HMPREF0659_RS04095
uniprot id: D9RS01
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

553174:HMPREF0659 RS02180
gene id: 553174:HMPREF0659_RS02180
uniprot id: D9RTW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

553174:HMPREF0659 RS00255
gene id: 553174:HMPREF0659_RS00255
uniprot id: D9RR11
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

553174:HMPREF0659 RS02140
gene id: 553174:HMPREF0659_RS02140
uniprot id: D9RTV9
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS00115
gene id: 553174:HMPREF0659_RS00115
uniprot id: D9RTA3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

553174:HMPREF0659 RS05495
gene id: 553174:HMPREF0659_RS05495
uniprot id: D9RSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

553174:HMPREF0659 RS01720
gene id: 553174:HMPREF0659_RS01720
uniprot id: D9RTN0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

553174:HMPREF0659 RS04665
gene id: 553174:HMPREF0659_RS04665
uniprot id: D9RUI4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

553174:HMPREF0659 RS09350
gene id: 553174:HMPREF0659_RS09350
uniprot id: D9RW19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

553174:HMPREF0659 RS00410
gene id: 553174:HMPREF0659_RS00410
uniprot id: D9RR42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS01050
gene id: 553174:HMPREF0659_RS01050
uniprot id: D9RRG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

553174:HMPREF0659 RS01725
gene id: 553174:HMPREF0659_RS01725
uniprot id: D9RTN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

553174:HMPREF0659 RS01505
gene id: 553174:HMPREF0659_RS01505
uniprot id: D9RTI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

553174:HMPREF0659 RS01680
gene id: 553174:HMPREF0659_RS01680
uniprot id: D9RTM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

553174:HMPREF0659 RS07900
gene id: 553174:HMPREF0659_RS07900
uniprot id: D9RV89
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS06465
gene id: 553174:HMPREF0659_RS06465
uniprot id: D9RSV5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS02980
gene id: 553174:HMPREF0659_RS02980
uniprot id: D9RRR8
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

553174:HMPREF0659 RS03880
gene id: 553174:HMPREF0659_RS03880
uniprot id: D9RRV6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

553174:HMPREF0659 RS07510
gene id: 553174:HMPREF0659_RS07510
uniprot id: D9RV16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

553174:HMPREF0659 RS03395
gene id: 553174:HMPREF0659_RS03395
uniprot id: D9RU71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

553174:HMPREF0659 RS00220
gene id: 553174:HMPREF0659_RS00220
uniprot id: D9RR05
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

553174:HMPREF0659 RS11580
gene id: 553174:HMPREF0659_RS11580
uniprot id: D9RX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS02850
gene id: 553174:HMPREF0659_RS02850
uniprot id: D9RRP4
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

553174:HMPREF0659 RS02885
gene id: 553174:HMPREF0659_RS02885
uniprot id: D9RRQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

553174:HMPREF0659 RS07985
gene id: 553174:HMPREF0659_RS07985
uniprot id: D9RVA5
names: Similarity
messages: Belongs to the peptidase C10 family.

553174:HMPREF0659 RS10090
gene id: 553174:HMPREF0659_RS10090
uniprot id: D9RWH1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

553174:HMPREF0659 RS11955
gene id: 553174:HMPREF0659_RS11955
uniprot id: D9RXF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS01045
gene id: 553174:HMPREF0659_RS01045
uniprot id: D9RRG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

553174:HMPREF0659 RS01700
gene id: 553174:HMPREF0659_RS01700
uniprot id: D9RTM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

553174:HMPREF0659 RS11945
gene id: 553174:HMPREF0659_RS11945
uniprot id: D9RXF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

553174:HMPREF0659 RS04150
gene id: 553174:HMPREF0659_RS04150
uniprot id: D9RS10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

553174:HMPREF0659 RS00215
gene id: 553174:HMPREF0659_RS00215
uniprot id: D9RR04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

553174:HMPREF0659 RS07485
gene id: 553174:HMPREF0659_RS07485
uniprot id: D9RV11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

553174:HMPREF0659 RS11460
gene id: 553174:HMPREF0659_RS11460
uniprot id: D9RX65
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

553174:HMPREF0659 RS09290
gene id: 553174:HMPREF0659_RS09290
uniprot id: D9RW07
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

553174:HMPREF0659 RS00075
gene id: 553174:HMPREF0659_RS00075
uniprot id: D9RT95
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

553174:HMPREF0659 RS10770
gene id: 553174:HMPREF0659_RS10770
uniprot id: D9RWT9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

553174:HMPREF0659 RS05265
gene id: 553174:HMPREF0659_RS05265
uniprot id: D9RS83
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

553174:HMPREF0659 RS10865
gene id: 553174:HMPREF0659_RS10865
uniprot id: D9RWV2
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS06760
gene id: 553174:HMPREF0659_RS06760
uniprot id: D9RT12
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

553174:HMPREF0659 RS03860
gene id: 553174:HMPREF0659_RS03860
uniprot id: D9RRV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

553174:HMPREF0659 RS01645
gene id: 553174:HMPREF0659_RS01645
uniprot id: D9RTL5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

553174:HMPREF0659 RS06115
gene id: 553174:HMPREF0659_RS06115
uniprot id: D9RSN8
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

553174:HMPREF0659 RS08110
gene id: 553174:HMPREF0659_RS08110
uniprot id: D9RVD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class A bacterial acid phosphatase family.
messages: Periplasm

553174:HMPREF0659 RS00315
gene id: 553174:HMPREF0659_RS00315
uniprot id: D9RR23
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

553174:HMPREF0659 RS01270
gene id: 553174:HMPREF0659_RS01270
uniprot id: D9RTF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS09395
gene id: 553174:HMPREF0659_RS09395
uniprot id: D9RW28
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

553174:HMPREF0659 RS01290
gene id: 553174:HMPREF0659_RS01290
uniprot id: D9RTF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

553174:HMPREF0659 RS09910
gene id: 553174:HMPREF0659_RS09910
uniprot id: D9RWD5
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS02065
gene id: 553174:HMPREF0659_RS02065
uniprot id: D9RTU4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

553174:HMPREF0659 RS01285
gene id: 553174:HMPREF0659_RS01285
uniprot id: D9RTF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

553174:HMPREF0659 RS03255
gene id: 553174:HMPREF0659_RS03255
uniprot id: D9RU43
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

553174:HMPREF0659 RS05700
gene id: 553174:HMPREF0659_RS05700
uniprot id: D9RSG6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

553174:HMPREF0659 RS05915
gene id: 553174:HMPREF0659_RS05915
uniprot id: D9RSK4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

553174:HMPREF0659 RS02875
gene id: 553174:HMPREF0659_RS02875
uniprot id: D9RRQ0
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

553174:HMPREF0659 RS01105
gene id: 553174:HMPREF0659_RS01105
uniprot id: D9RTC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

553174:HMPREF0659 RS08415
gene id: 553174:HMPREF0659_RS08415
uniprot id: D9RVI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

553174:HMPREF0659 RS02580
gene id: 553174:HMPREF0659_RS02580
uniprot id: D9RRJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

553174:HMPREF0659 RS05600
gene id: 553174:HMPREF0659_RS05600
uniprot id: D9RSE7
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

553174:HMPREF0659 RS01520
gene id: 553174:HMPREF0659_RS01520
uniprot id: D9RTJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

553174:HMPREF0659 RS06625
gene id: 553174:HMPREF0659_RS06625
uniprot id: D9RSY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

553174:HMPREF0659 RS01595
gene id: 553174:HMPREF0659_RS01595
uniprot id: D9RTK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

553174:HMPREF0659 RS10930
gene id: 553174:HMPREF0659_RS10930
uniprot id: D9RWW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

553174:HMPREF0659 RS00560
gene id: 553174:HMPREF0659_RS00560
uniprot id: D9RR71
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

553174:HMPREF0659 RS00905
gene id: 553174:HMPREF0659_RS00905
uniprot id: D9RRD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

553174:HMPREF0659 RS02820
gene id: 553174:HMPREF0659_RS02820
uniprot id: D9RRN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

553174:HMPREF0659 RS08730
gene id: 553174:HMPREF0659_RS08730
uniprot id: D9RVP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

553174:HMPREF0659 RS07795
gene id: 553174:HMPREF0659_RS07795
uniprot id: D9RV70
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS02325
gene id: 553174:HMPREF0659_RS02325
uniprot id: D9RTZ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

553174:HMPREF0659 RS04955
gene id: 553174:HMPREF0659_RS04955
uniprot id: D9RUN3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS04080
gene id: 553174:HMPREF0659_RS04080
uniprot id: D9RRZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

553174:HMPREF0659 RS02995
gene id: 553174:HMPREF0659_RS02995
uniprot id: D9RRS1
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS00980
gene id: 553174:HMPREF0659_RS00980
uniprot id: D9RRF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

553174:HMPREF0659 RS06390
gene id: 553174:HMPREF0659_RS06390
uniprot id: D9RSU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

553174:HMPREF0659 RS01970
gene id: 553174:HMPREF0659_RS01970
uniprot id: D9RTS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

553174:HMPREF0659 RS01000
gene id: 553174:HMPREF0659_RS01000
uniprot id: D9RRF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS05325
gene id: 553174:HMPREF0659_RS05325
uniprot id: D9RS92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

553174:HMPREF0659 RS00645
gene id: 553174:HMPREF0659_RS00645
uniprot id: D9RR89
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS01705
gene id: 553174:HMPREF0659_RS01705
uniprot id: D9RTM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

553174:HMPREF0659 RS08725
gene id: 553174:HMPREF0659_RS08725
uniprot id: D9RVP8
names: Similarity
messages: Belongs to the AIR synthase family.

553174:HMPREF0659 RS04405
gene id: 553174:HMPREF0659_RS04405
uniprot id: D9RS52
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

553174:HMPREF0659 RS06385
gene id: 553174:HMPREF0659_RS06385
uniprot id: D9RST9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

553174:HMPREF0659 RS09950
gene id: 553174:HMPREF0659_RS09950
uniprot id: D9RWE3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

553174:HMPREF0659 RS05980
gene id: 553174:HMPREF0659_RS05980
uniprot id: D9RSL7
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

553174:HMPREF0659 RS12115
gene id: 553174:HMPREF0659_RS12115
uniprot id: D9RXH5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

553174:HMPREF0659 RS02870
gene id: 553174:HMPREF0659_RS02870
uniprot id: D9RRP9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

553174:HMPREF0659 RS08645
gene id: 553174:HMPREF0659_RS08645
uniprot id: D9RVN3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

553174:HMPREF0659 RS00155
gene id: 553174:HMPREF0659_RS00155
uniprot id: D9RTB1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

553174:HMPREF0659 RS00660
gene id: 553174:HMPREF0659_RS00660
uniprot id: D9RR92
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

553174:HMPREF0659 RS09725
gene id: 553174:HMPREF0659_RS09725
uniprot id: D9RW97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

553174:HMPREF0659 RS08450
gene id: 553174:HMPREF0659_RS08450
uniprot id: D9RVJ5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

553174:HMPREF0659 RS08975
gene id: 553174:HMPREF0659_RS08975
uniprot id: D9RVU6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

553174:HMPREF0659 RS07080
gene id: 553174:HMPREF0659_RS07080
uniprot id: D9RT73
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS03755
gene id: 553174:HMPREF0659_RS03755
uniprot id: D9RUE0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

553174:HMPREF0659 RS08640
gene id: 553174:HMPREF0659_RS08640
uniprot id: D9RVN2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS09325
gene id: 553174:HMPREF0659_RS09325
uniprot id: D9RW14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

553174:HMPREF0659 RS07030
gene id: 553174:HMPREF0659_RS07030
uniprot id: D9RT62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

553174:HMPREF0659 RS02210
gene id: 553174:HMPREF0659_RS02210
uniprot id: D9RTX4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

553174:HMPREF0659 RS07105
gene id: 553174:HMPREF0659_RS07105
uniprot id: D9RT78
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS02665
gene id: 553174:HMPREF0659_RS02665
uniprot id: D9RRK7
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

553174:HMPREF0659 RS00345
gene id: 553174:HMPREF0659_RS00345
uniprot id: D9RR29
names: Similarity
messages: Belongs to the DapB family.

553174:HMPREF0659 RS01440
gene id: 553174:HMPREF0659_RS01440
uniprot id: D9RTI0
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS10030
gene id: 553174:HMPREF0659_RS10030
uniprot id: D9RWG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

553174:HMPREF0659 RS00150
gene id: 553174:HMPREF0659_RS00150
uniprot id: D9RTB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

553174:HMPREF0659 RS01995
gene id: 553174:HMPREF0659_RS01995
uniprot id: D9RTT1
names: Similarity
messages: Belongs to the RutC family.

553174:HMPREF0659 RS09485
gene id: 553174:HMPREF0659_RS09485
uniprot id: D9RW45
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

553174:HMPREF0659 RS04570
gene id: 553174:HMPREF0659_RS04570
uniprot id: D9RUG3
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS07375
gene id: 553174:HMPREF0659_RS07375
uniprot id: D9RUY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

553174:HMPREF0659 RS07110
gene id: 553174:HMPREF0659_RS07110
uniprot id: D9RT79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS08990
gene id: 553174:HMPREF0659_RS08990
uniprot id: D9RVU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

553174:HMPREF0659 RS10670
gene id: 553174:HMPREF0659_RS10670
uniprot id: D9RWS0
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS07100
gene id: 553174:HMPREF0659_RS07100
uniprot id: D9RT77
names: Subcellular Location Annotation
messages: Membrane

553174:HMPREF0659 RS02225
gene id: 553174:HMPREF0659_RS02225
uniprot id: D9RTX7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS11515
gene id: 553174:HMPREF0659_RS11515
uniprot id: D9RX75
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

553174:HMPREF0659 RS10990
gene id: 553174:HMPREF0659_RS10990
uniprot id: D9RWX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS06225
gene id: 553174:HMPREF0659_RS06225
uniprot id: D9RSQ9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

553174:HMPREF0659 RS05260
gene id: 553174:HMPREF0659_RS05260
uniprot id: D9RS82
names: Similarity
messages: Belongs to the isochorismate synthase family.

553174:HMPREF0659 RS03975
gene id: 553174:HMPREF0659_RS03975
uniprot id: D9RRX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

553174:HMPREF0659 RS01945
gene id: 553174:HMPREF0659_RS01945
uniprot id: D9RTS1
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

553174:HMPREF0659 RS06720
gene id: 553174:HMPREF0659_RS06720
uniprot id: D9RT03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

553174:HMPREF0659 RS09420
gene id: 553174:HMPREF0659_RS09420
uniprot id: D9RW33
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS10270
gene id: 553174:HMPREF0659_RS10270
uniprot id: D9RWK2
names: Subcellular Location Annotation
messages: Secreted

553174:HMPREF0659 RS05850
gene id: 553174:HMPREF0659_RS05850
uniprot id: D9RSJ1
names: Similarity
messages: Belongs to the CvfB family.

553174:HMPREF0659 RS06420
gene id: 553174:HMPREF0659_RS06420
uniprot id: D9RSU7
names: Similarity
messages: Belongs to the SusD family.

553174:HMPREF0659 RS05610
gene id: 553174:HMPREF0659_RS05610
uniprot id: D9RSE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

553174:HMPREF0659 RS11645
gene id: 553174:HMPREF0659_RS11645
uniprot id: D9RX96
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

553174:HMPREF0659 RS00605
gene id: 553174:HMPREF0659_RS00605
uniprot id: D9RR80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

553174:HMPREF0659 RS07605
gene id: 553174:HMPREF0659_RS07605
uniprot id: D9RV33
names: Similarity
messages: Belongs to the FBPase class 3 family.

553174:HMPREF0659 RS06140
gene id: 553174:HMPREF0659_RS06140
uniprot id: D9RSP3
names: Similarity
messages: Belongs to the UPF0758 family.

553174:HMPREF0659 RS04780
gene id: 553174:HMPREF0659_RS04780
uniprot id: D9RUK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

553174:HMPREF0659 RS10120
gene id: 553174:HMPREF0659_RS10120
uniprot id: D9RWH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

553174:HMPREF0659 RS07450
gene id: 553174:HMPREF0659_RS07450
uniprot id: D9RV03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

553174:HMPREF0659 RS08195
gene id: 553174:HMPREF0659_RS08195
uniprot id: D9RVE5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

553174:HMPREF0659 RS03005
gene id: 553174:HMPREF0659_RS03005
uniprot id: D9RRS3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

553174:HMPREF0659 RS01715
gene id: 553174:HMPREF0659_RS01715
uniprot id: D9RTM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

553174:HMPREF0659 RS03150
gene id: 553174:HMPREF0659_RS03150
uniprot id: D9RRU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.