548479:HMPREF0573 RS08280
gene id: 548479:HMPREF0573_RS08280
uniprot id: D6ZHA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS02960
gene id: 548479:HMPREF0573_RS02960
uniprot id: D6ZJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

548479:HMPREF0573 RS03640
gene id: 548479:HMPREF0573_RS03640
uniprot id: D6ZK07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

548479:HMPREF0573 RS01540
gene id: 548479:HMPREF0573_RS01540
uniprot id: D6ZIT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

548479:HMPREF0573 RS07850
gene id: 548479:HMPREF0573_RS07850
uniprot id: D6ZH17
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

548479:HMPREF0573 RS06925
gene id: 548479:HMPREF0573_RS06925
uniprot id: D6ZGH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

548479:HMPREF0573 RS02385
gene id: 548479:HMPREF0573_RS02385
uniprot id: D6ZJA1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

548479:HMPREF0573 RS04785
gene id: 548479:HMPREF0573_RS04785
uniprot id: D6ZKP1
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS08775
gene id: 548479:HMPREF0573_RS08775
uniprot id: D6ZHK6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

548479:HMPREF0573 RS04230
gene id: 548479:HMPREF0573_RS04230
uniprot id: D6ZKC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

548479:HMPREF0573 RS08510
gene id: 548479:HMPREF0573_RS08510
uniprot id: D6ZHF1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

548479:HMPREF0573 RS00800
gene id: 548479:HMPREF0573_RS00800
uniprot id: D6ZID0
names: Similarity
messages: Belongs to the peptidase M24B family.

548479:HMPREF0573 RS02705
gene id: 548479:HMPREF0573_RS02705
uniprot id: D6ZJG4
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

548479:HMPREF0573 RS05430
gene id: 548479:HMPREF0573_RS05430
uniprot id: D6ZL23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

548479:HMPREF0573 RS01655
gene id: 548479:HMPREF0573_RS01655
uniprot id: D6ZIW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

548479:HMPREF0573 RS02885
gene id: 548479:HMPREF0573_RS02885
uniprot id: D6ZJK4
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS02510
gene id: 548479:HMPREF0573_RS02510
uniprot id: D6ZJC5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

548479:HMPREF0573 RS09010
gene id: 548479:HMPREF0573_RS09010
uniprot id: D6ZHQ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

548479:HMPREF0573 RS01485
gene id: 548479:HMPREF0573_RS01485
uniprot id: D6ZIS5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS08145
gene id: 548479:HMPREF0573_RS08145
uniprot id: D6ZH77
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

548479:HMPREF0573 RS08525
gene id: 548479:HMPREF0573_RS08525
uniprot id: D6ZHF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

548479:HMPREF0573 RS00190
gene id: 548479:HMPREF0573_RS00190
uniprot id: D6ZI01
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

548479:HMPREF0573 RS05685
gene id: 548479:HMPREF0573_RS05685
uniprot id: D6ZL77
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS02035
gene id: 548479:HMPREF0573_RS02035
uniprot id: D6ZJ39
names: Similarity
messages: Belongs to the peptidase S13 family.

548479:HMPREF0573 RS07040
gene id: 548479:HMPREF0573_RS07040
uniprot id: D6ZGK0
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS08915
gene id: 548479:HMPREF0573_RS08915
uniprot id: D6ZHN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

548479:HMPREF0573 RS00480
gene id: 548479:HMPREF0573_RS00480
uniprot id: D6ZI57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

548479:HMPREF0573 RS04925
gene id: 548479:HMPREF0573_RS04925
uniprot id: D6ZKS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

548479:HMPREF0573 RS01025
gene id: 548479:HMPREF0573_RS01025
uniprot id: D6ZIH4
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS01850
gene id: 548479:HMPREF0573_RS01850
uniprot id: D6ZJ02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

548479:HMPREF0573 RS03900
gene id: 548479:HMPREF0573_RS03900
uniprot id: D6ZK60
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

548479:HMPREF0573 RS08575
gene id: 548479:HMPREF0573_RS08575
uniprot id: D6ZHG4
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

548479:HMPREF0573 RS04920
gene id: 548479:HMPREF0573_RS04920
uniprot id: D6ZKS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

548479:HMPREF0573 RS08495
gene id: 548479:HMPREF0573_RS08495
uniprot id: D6ZHE8
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

548479:HMPREF0573 RS03610
gene id: 548479:HMPREF0573_RS03610
uniprot id: D6ZK01
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

548479:HMPREF0573 RS08015
gene id: 548479:HMPREF0573_RS08015
uniprot id: D6ZH52
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

548479:HMPREF0573 RS01290
gene id: 548479:HMPREF0573_RS01290
uniprot id: D6ZIN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS02915
gene id: 548479:HMPREF0573_RS02915
uniprot id: D6ZJL0
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS01510
gene id: 548479:HMPREF0573_RS01510
uniprot id: D6ZIT2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

548479:HMPREF0573 RS00720
gene id: 548479:HMPREF0573_RS00720
uniprot id: D6ZIB3
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS02270
gene id: 548479:HMPREF0573_RS02270
uniprot id: D6ZJ83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

548479:HMPREF0573 RS01220
gene id: 548479:HMPREF0573_RS01220
uniprot id: D6ZIL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS09130
gene id: 548479:HMPREF0573_RS09130
uniprot id: D6ZHS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS01270
gene id: 548479:HMPREF0573_RS01270
uniprot id: D6ZIN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS03840
gene id: 548479:HMPREF0573_RS03840
uniprot id: D6ZK48
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

548479:HMPREF0573 RS08310
gene id: 548479:HMPREF0573_RS08310
uniprot id: D6ZHB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

548479:HMPREF0573 RS00880
gene id: 548479:HMPREF0573_RS00880
uniprot id: D6ZIE7
names: Similarity
messages: Belongs to the FPG family.

548479:HMPREF0573 RS00055
gene id: 548479:HMPREF0573_RS00055
uniprot id: D6ZHX4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

548479:HMPREF0573 RS09550
gene id: 548479:HMPREF0573_RS09550
uniprot id: D6ZL57
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

548479:HMPREF0573 RS05895
gene id: 548479:HMPREF0573_RS05895
uniprot id: D6ZFW0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

548479:HMPREF0573 RS00630
gene id: 548479:HMPREF0573_RS00630
uniprot id: D6ZI92
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS04780
gene id: 548479:HMPREF0573_RS04780
uniprot id: D6ZKP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

548479:HMPREF0573 RS03530
gene id: 548479:HMPREF0573_RS03530
uniprot id: D6ZJY5
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS04845
gene id: 548479:HMPREF0573_RS04845
uniprot id: D6ZKQ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

548479:HMPREF0573 RS03415
gene id: 548479:HMPREF0573_RS03415
uniprot id: D6ZJV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

548479:HMPREF0573 RS04935
gene id: 548479:HMPREF0573_RS04935
uniprot id: D6ZKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

548479:HMPREF0573 RS02480
gene id: 548479:HMPREF0573_RS02480
uniprot id: D6ZJB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

548479:HMPREF0573 RS01725
gene id: 548479:HMPREF0573_RS01725
uniprot id: D6ZIX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

548479:HMPREF0573 RS03970
gene id: 548479:HMPREF0573_RS03970
uniprot id: D6ZK76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS08995
gene id: 548479:HMPREF0573_RS08995
uniprot id: D6ZHQ1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

548479:HMPREF0573 RS02390
gene id: 548479:HMPREF0573_RS02390
uniprot id: D6ZJA2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

548479:HMPREF0573 RS05145
gene id: 548479:HMPREF0573_RS05145
uniprot id: D6ZKW6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

548479:HMPREF0573 RS08345
gene id: 548479:HMPREF0573_RS08345
uniprot id: D6ZHB7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS03275
gene id: 548479:HMPREF0573_RS03275
uniprot id: D6ZJS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

548479:HMPREF0573 RS09225
gene id: 548479:HMPREF0573_RS09225
uniprot id: D6ZHU7
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS07805
gene id: 548479:HMPREF0573_RS07805
uniprot id: D6ZH08
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

548479:HMPREF0573 RS02230
gene id: 548479:HMPREF0573_RS02230
uniprot id: D6ZJ75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

548479:HMPREF0573 RS01415
gene id: 548479:HMPREF0573_RS01415
uniprot id: D6ZIR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

548479:HMPREF0573 RS05755
gene id: 548479:HMPREF0573_RS05755
uniprot id: D6ZFT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

548479:HMPREF0573 RS04730
gene id: 548479:HMPREF0573_RS04730
uniprot id: D6ZKM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

548479:HMPREF0573 RS00815
gene id: 548479:HMPREF0573_RS00815
uniprot id: D6ZID3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

548479:HMPREF0573 RS00170
gene id: 548479:HMPREF0573_RS00170
uniprot id: D6ZHZ7
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS03895
gene id: 548479:HMPREF0573_RS03895
uniprot id: D6ZK59
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

548479:HMPREF0573 RS04260
gene id: 548479:HMPREF0573_RS04260
uniprot id: D6ZKD5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

548479:HMPREF0573 RS07705
gene id: 548479:HMPREF0573_RS07705
uniprot id: D6ZGY8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS07070
gene id: 548479:HMPREF0573_RS07070
uniprot id: D6ZGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

548479:HMPREF0573 RS04410
gene id: 548479:HMPREF0573_RS04410
uniprot id: D6ZKG5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

548479:HMPREF0573 RS01210
gene id: 548479:HMPREF0573_RS01210
uniprot id: D6ZIL2
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

548479:HMPREF0573 RS07485
gene id: 548479:HMPREF0573_RS07485
uniprot id: D6ZGU4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS03120
gene id: 548479:HMPREF0573_RS03120
uniprot id: D6ZJP9
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

548479:HMPREF0573 RS00895
gene id: 548479:HMPREF0573_RS00895
uniprot id: D6ZIF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

548479:HMPREF0573 RS07690
gene id: 548479:HMPREF0573_RS07690
uniprot id: D6ZGY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

548479:HMPREF0573 RS04900
gene id: 548479:HMPREF0573_RS04900
uniprot id: D6ZKR7
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

548479:HMPREF0573 RS03855
gene id: 548479:HMPREF0573_RS03855
uniprot id: D6ZK51
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

548479:HMPREF0573 RS01580
gene id: 548479:HMPREF0573_RS01580
uniprot id: D6ZIU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

548479:HMPREF0573 RS00935
gene id: 548479:HMPREF0573_RS00935
uniprot id: D6ZIF8
names: Similarity
messages: Belongs to the peptidase M1 family.

548479:HMPREF0573 RS01395
gene id: 548479:HMPREF0573_RS01395
uniprot id: D6ZIQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

548479:HMPREF0573 RS05290
gene id: 548479:HMPREF0573_RS05290
uniprot id: D6ZKZ5
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

548479:HMPREF0573 RS03445
gene id: 548479:HMPREF0573_RS03445
uniprot id: D6ZJW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.

548479:HMPREF0573 RS04335
gene id: 548479:HMPREF0573_RS04335
uniprot id: D6ZKF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

548479:HMPREF0573 RS06505
gene id: 548479:HMPREF0573_RS06505
uniprot id: D6ZG93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

548479:HMPREF0573 RS07590
gene id: 548479:HMPREF0573_RS07590
uniprot id: D6ZGW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

548479:HMPREF0573 RS03000
gene id: 548479:HMPREF0573_RS03000
uniprot id: D6ZJM7
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

548479:HMPREF0573 RS06635
gene id: 548479:HMPREF0573_RS06635
uniprot id: D6ZGC1
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS01310
gene id: 548479:HMPREF0573_RS01310
uniprot id: D6ZIP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

548479:HMPREF0573 RS03410
gene id: 548479:HMPREF0573_RS03410
uniprot id: D6ZJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

548479:HMPREF0573 RS05725
gene id: 548479:HMPREF0573_RS05725
uniprot id: D6ZFS6
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

548479:HMPREF0573 RS05340
gene id: 548479:HMPREF0573_RS05340
uniprot id: D6ZL05
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

548479:HMPREF0573 RS05295
gene id: 548479:HMPREF0573_RS05295
uniprot id: D6ZKZ6
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

548479:HMPREF0573 RS00160
gene id: 548479:HMPREF0573_RS00160
uniprot id: D6ZHZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

548479:HMPREF0573 RS04895
gene id: 548479:HMPREF0573_RS04895
uniprot id: D6ZKR6
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

548479:HMPREF0573 RS03865
gene id: 548479:HMPREF0573_RS03865
uniprot id: D6ZK53
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

548479:HMPREF0573 RS03505
gene id: 548479:HMPREF0573_RS03505
uniprot id: D6ZJX9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

548479:HMPREF0573 RS03145
gene id: 548479:HMPREF0573_RS03145
uniprot id: D6ZJQ4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

548479:HMPREF0573 RS08465
gene id: 548479:HMPREF0573_RS08465
uniprot id: D6ZHE2
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

548479:HMPREF0573 RS08425
gene id: 548479:HMPREF0573_RS08425
uniprot id: D6ZHD4
names: Similarity
messages: Belongs to the peptidase A24 family.

548479:HMPREF0573 RS06110
gene id: 548479:HMPREF0573_RS06110
uniprot id: D6ZG08
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

548479:HMPREF0573 RS00665
gene id: 548479:HMPREF0573_RS00665
uniprot id: D6ZIA0
names: Similarity
messages: Belongs to the CapA family.

548479:HMPREF0573 RS05800
gene id: 548479:HMPREF0573_RS05800
uniprot id: D6ZFU3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

548479:HMPREF0573 RS06390
gene id: 548479:HMPREF0573_RS06390
uniprot id: D6ZG69
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS07270
gene id: 548479:HMPREF0573_RS07270
uniprot id: D6ZGP8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

548479:HMPREF0573 RS00125
gene id: 548479:HMPREF0573_RS00125
uniprot id: D6ZHY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS04600
gene id: 548479:HMPREF0573_RS04600
uniprot id: D6ZKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

548479:HMPREF0573 RS04625
gene id: 548479:HMPREF0573_RS04625
uniprot id: D6ZKK8
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS02900
gene id: 548479:HMPREF0573_RS02900
uniprot id: D6ZJK7
names: Similarity
messages: Belongs to the BtpA family.

548479:HMPREF0573 RS05080
gene id: 548479:HMPREF0573_RS05080
uniprot id: D6ZKV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

548479:HMPREF0573 RS00610
gene id: 548479:HMPREF0573_RS00610
uniprot id: D6ZI87
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

548479:HMPREF0573 RS03285
gene id: 548479:HMPREF0573_RS03285
uniprot id: D6ZJT2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

548479:HMPREF0573 RS00495
gene id: 548479:HMPREF0573_RS00495
uniprot id: D6ZI61
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

548479:HMPREF0573 RS08705
gene id: 548479:HMPREF0573_RS08705
uniprot id: D6ZHJ1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

548479:HMPREF0573 RS01400
gene id: 548479:HMPREF0573_RS01400
uniprot id: D6ZIQ8
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

548479:HMPREF0573 RS05365
gene id: 548479:HMPREF0573_RS05365
uniprot id: D6ZL10
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS00595
gene id: 548479:HMPREF0573_RS00595
uniprot id: D6ZI83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

548479:HMPREF0573 RS09065
gene id: 548479:HMPREF0573_RS09065
uniprot id: D6ZHR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS04305
gene id: 548479:HMPREF0573_RS04305
uniprot id: D6ZKE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

548479:HMPREF0573 RS01265
gene id: 548479:HMPREF0573_RS01265
uniprot id: D6ZIN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS08440
gene id: 548479:HMPREF0573_RS08440
uniprot id: D6ZHD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

548479:HMPREF0573 RS04190
gene id: 548479:HMPREF0573_RS04190
uniprot id: D6ZKC1
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

548479:HMPREF0573 RS00510
gene id: 548479:HMPREF0573_RS00510
uniprot id: D6ZI65
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

548479:HMPREF0573 RS04965
gene id: 548479:HMPREF0573_RS04965
uniprot id: D6ZKT0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

548479:HMPREF0573 RS02295
gene id: 548479:HMPREF0573_RS02295
uniprot id: D6ZJ88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

548479:HMPREF0573 RS08115
gene id: 548479:HMPREF0573_RS08115
uniprot id: D6ZH71
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

548479:HMPREF0573 RS00705
gene id: 548479:HMPREF0573_RS00705
uniprot id: D6ZIB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

548479:HMPREF0573 RS08175
gene id: 548479:HMPREF0573_RS08175
uniprot id: D6ZH82
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

548479:HMPREF0573 RS02645
gene id: 548479:HMPREF0573_RS02645
uniprot id: D6ZJF1
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS02505
gene id: 548479:HMPREF0573_RS02505
uniprot id: D6ZJC4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

548479:HMPREF0573 RS03920
gene id: 548479:HMPREF0573_RS03920
uniprot id: D6ZK64
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

548479:HMPREF0573 RS01640
gene id: 548479:HMPREF0573_RS01640
uniprot id: D6ZIV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

548479:HMPREF0573 RS03725
gene id: 548479:HMPREF0573_RS03725
uniprot id: D6ZK25
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

548479:HMPREF0573 RS08180
gene id: 548479:HMPREF0573_RS08180
uniprot id: D6ZH83
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS06105
gene id: 548479:HMPREF0573_RS06105
uniprot id: D6ZG07
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

548479:HMPREF0573 RS03870
gene id: 548479:HMPREF0573_RS03870
uniprot id: D6ZK54
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

548479:HMPREF0573 RS01125
gene id: 548479:HMPREF0573_RS01125
uniprot id: D6ZIJ4
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS02055
gene id: 548479:HMPREF0573_RS02055
uniprot id: D6ZJ43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

548479:HMPREF0573 RS02115
gene id: 548479:HMPREF0573_RS02115
uniprot id: D6ZJ56
names: Similarity
messages: Belongs to the Nudix hydrolase family.

548479:HMPREF0573 RS07660
gene id: 548479:HMPREF0573_RS07660
uniprot id: D6ZGX9
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

548479:HMPREF0573 RS05230
gene id: 548479:HMPREF0573_RS05230
uniprot id: D6ZKY3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

548479:HMPREF0573 RS01435
gene id: 548479:HMPREF0573_RS01435
uniprot id: D6ZIR5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

548479:HMPREF0573 RS06590
gene id: 548479:HMPREF0573_RS06590
uniprot id: D6ZGB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

548479:HMPREF0573 RS06480
gene id: 548479:HMPREF0573_RS06480
uniprot id: D6ZG88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

548479:HMPREF0573 RS03625
gene id: 548479:HMPREF0573_RS03625
uniprot id: D6ZK04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

548479:HMPREF0573 RS07245
gene id: 548479:HMPREF0573_RS07245
uniprot id: D6ZGP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

548479:HMPREF0573 RS09115
gene id: 548479:HMPREF0573_RS09115
uniprot id: D6ZHS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

548479:HMPREF0573 RS03630
gene id: 548479:HMPREF0573_RS03630
uniprot id: D6ZK05
names: Function
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

548479:HMPREF0573 RS08005
gene id: 548479:HMPREF0573_RS08005
uniprot id: D6ZH50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

548479:HMPREF0573 RS04710
gene id: 548479:HMPREF0573_RS04710
uniprot id: D6ZKM5
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

548479:HMPREF0573 RS08110
gene id: 548479:HMPREF0573_RS08110
uniprot id: D6ZH70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

548479:HMPREF0573 RS05265
gene id: 548479:HMPREF0573_RS05265
uniprot id: D6ZKZ0
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

548479:HMPREF0573 RS07895
gene id: 548479:HMPREF0573_RS07895
uniprot id: D6ZH26
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Homodimer.

548479:HMPREF0573 RS08020
gene id: 548479:HMPREF0573_RS08020
uniprot id: D6ZH53
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

548479:HMPREF0573 RS08420
gene id: 548479:HMPREF0573_RS08420
uniprot id: D6ZHD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

548479:HMPREF0573 RS03230
gene id: 548479:HMPREF0573_RS03230
uniprot id: D6ZJS0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS01460
gene id: 548479:HMPREF0573_RS01460
uniprot id: D6ZIS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS01595
gene id: 548479:HMPREF0573_RS01595
uniprot id: D6ZIU9
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

548479:HMPREF0573 RS00605
gene id: 548479:HMPREF0573_RS00605
uniprot id: D6ZI86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

548479:HMPREF0573 RS09120
gene id: 548479:HMPREF0573_RS09120
uniprot id: D6ZHS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

548479:HMPREF0573 RS08360
gene id: 548479:HMPREF0573_RS08360
uniprot id: D6ZHC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

548479:HMPREF0573 RS08190
gene id: 548479:HMPREF0573_RS08190
uniprot id: D6ZH85
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

548479:HMPREF0573 RS02355
gene id: 548479:HMPREF0573_RS02355
uniprot id: D6ZJ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS03910
gene id: 548479:HMPREF0573_RS03910
uniprot id: D6ZK62
names: Similarity
messages: Belongs to the XseB family.

548479:HMPREF0573 RS07595
gene id: 548479:HMPREF0573_RS07595
uniprot id: D6ZGW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

548479:HMPREF0573 RS02040
gene id: 548479:HMPREF0573_RS02040
uniprot id: D6ZJ40
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

548479:HMPREF0573 RS03345
gene id: 548479:HMPREF0573_RS03345
uniprot id: D6ZJU3
names: Similarity
messages: Belongs to the peptidase S11 family.

548479:HMPREF0573 RS04945
gene id: 548479:HMPREF0573_RS04945
uniprot id: D6ZKS6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

548479:HMPREF0573 RS09105
gene id: 548479:HMPREF0573_RS09105
uniprot id: D6ZHS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

548479:HMPREF0573 RS08470
gene id: 548479:HMPREF0573_RS08470
uniprot id: D6ZHE3
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS03850
gene id: 548479:HMPREF0573_RS03850
uniprot id: D6ZK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

548479:HMPREF0573 RS04915
gene id: 548479:HMPREF0573_RS04915
uniprot id: D6ZKS0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

548479:HMPREF0573 RS07825
gene id: 548479:HMPREF0573_RS07825
uniprot id: D6ZH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS06465
gene id: 548479:HMPREF0573_RS06465
uniprot id: D6ZG85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

548479:HMPREF0573 RS08910
gene id: 548479:HMPREF0573_RS08910
uniprot id: D6ZHN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

548479:HMPREF0573 RS08390
gene id: 548479:HMPREF0573_RS08390
uniprot id: D6ZHC7
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

548479:HMPREF0573 RS02475
gene id: 548479:HMPREF0573_RS02475
uniprot id: D6ZJB8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

548479:HMPREF0573 RS04910
gene id: 548479:HMPREF0573_RS04910
uniprot id: D6ZKR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

548479:HMPREF0573 RS07890
gene id: 548479:HMPREF0573_RS07890
uniprot id: D6ZH25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

548479:HMPREF0573 RS08535
gene id: 548479:HMPREF0573_RS08535
uniprot id: D6ZHF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

548479:HMPREF0573 RS05105
gene id: 548479:HMPREF0573_RS05105
uniprot id: D6ZKV7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

548479:HMPREF0573 RS03245
gene id: 548479:HMPREF0573_RS03245
uniprot id: D6ZJS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

548479:HMPREF0573 RS01735
gene id: 548479:HMPREF0573_RS01735
uniprot id: D6ZIX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

548479:HMPREF0573 RS04225
gene id: 548479:HMPREF0573_RS04225
uniprot id: D6ZKC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

548479:HMPREF0573 RS00270
gene id: 548479:HMPREF0573_RS00270
uniprot id: D6ZI17
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS03540
gene id: 548479:HMPREF0573_RS03540
uniprot id: D6ZJY7
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Homodimer.

548479:HMPREF0573 RS05420
gene id: 548479:HMPREF0573_RS05420
uniprot id: D6ZL21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

548479:HMPREF0573 RS04275
gene id: 548479:HMPREF0573_RS04275
uniprot id: D6ZKD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS09020
gene id: 548479:HMPREF0573_RS09020
uniprot id: D6ZHQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

548479:HMPREF0573 RS03235
gene id: 548479:HMPREF0573_RS03235
uniprot id: D6ZJS1
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

548479:HMPREF0573 RS04345
gene id: 548479:HMPREF0573_RS04345
uniprot id: D6ZKF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

548479:HMPREF0573 RS04005
gene id: 548479:HMPREF0573_RS04005
uniprot id: D6ZK83
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

548479:HMPREF0573 RS05870
gene id: 548479:HMPREF0573_RS05870
uniprot id: D6ZFV5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

548479:HMPREF0573 RS07765
gene id: 548479:HMPREF0573_RS07765
uniprot id: D6ZH00
names: Similarity
messages: Belongs to the glutamine synthetase family.

548479:HMPREF0573 RS00855
gene id: 548479:HMPREF0573_RS00855
uniprot id: D6ZIE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

548479:HMPREF0573 RS02420
gene id: 548479:HMPREF0573_RS02420
uniprot id: D6ZJA8
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

548479:HMPREF0573 RS04195
gene id: 548479:HMPREF0573_RS04195
uniprot id: D6ZKC2
names: Similarity
messages: Belongs to the GARS family.

548479:HMPREF0573 RS03875
gene id: 548479:HMPREF0573_RS03875
uniprot id: D6ZK55
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

548479:HMPREF0573 RS01345
gene id: 548479:HMPREF0573_RS01345
uniprot id: D6ZIP7
names: Similarity
messages: Belongs to the AAA ATPase family.

548479:HMPREF0573 RS03225
gene id: 548479:HMPREF0573_RS03225
uniprot id: D6ZJR9
names: Similarity
messages: Belongs to the thioredoxin family.

548479:HMPREF0573 RS01505
gene id: 548479:HMPREF0573_RS01505
uniprot id: D6ZIT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

548479:HMPREF0573 RS05605
gene id: 548479:HMPREF0573_RS05605
uniprot id: D6ZL62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS02585
gene id: 548479:HMPREF0573_RS02585
uniprot id: D6ZJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

548479:HMPREF0573 RS03515
gene id: 548479:HMPREF0573_RS03515
uniprot id: D6ZJY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

548479:HMPREF0573 RS01035
gene id: 548479:HMPREF0573_RS01035
uniprot id: D6ZIH6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS05770
gene id: 548479:HMPREF0573_RS05770
uniprot id: D6ZFT7
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS04995
gene id: 548479:HMPREF0573_RS04995
uniprot id: D6ZKT5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

548479:HMPREF0573 RS08795
gene id: 548479:HMPREF0573_RS08795
uniprot id: D6ZHL0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'P' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Non-allosteric.

548479:HMPREF0573 RS07605
gene id: 548479:HMPREF0573_RS07605
uniprot id: D6ZGW8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

548479:HMPREF0573 RS00215
gene id: 548479:HMPREF0573_RS00215
uniprot id: D6ZI06
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

548479:HMPREF0573 RS02065
gene id: 548479:HMPREF0573_RS02065
uniprot id: D6ZJ45
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

548479:HMPREF0573 RS03175
gene id: 548479:HMPREF0573_RS03175
uniprot id: D6ZJQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS07780
gene id: 548479:HMPREF0573_RS07780
uniprot id: D6ZH03
names: Similarity
messages: Belongs to the FGGY kinase family.

548479:HMPREF0573 RS08770
gene id: 548479:HMPREF0573_RS08770
uniprot id: D6ZHK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

548479:HMPREF0573 RS00685
gene id: 548479:HMPREF0573_RS00685
uniprot id: D6ZIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

548479:HMPREF0573 RS08030
gene id: 548479:HMPREF0573_RS08030
uniprot id: D6ZH55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS07550
gene id: 548479:HMPREF0573_RS07550
uniprot id: D6ZGV7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

548479:HMPREF0573 RS03055
gene id: 548479:HMPREF0573_RS03055
uniprot id: D6ZJN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

548479:HMPREF0573 RS07305
gene id: 548479:HMPREF0573_RS07305
uniprot id: D6ZGQ5
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

548479:HMPREF0573 RS06995
gene id: 548479:HMPREF0573_RS06995
uniprot id: D6ZGJ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS07335
gene id: 548479:HMPREF0573_RS07335
uniprot id: D6ZGR1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

548479:HMPREF0573 RS07235
gene id: 548479:HMPREF0573_RS07235
uniprot id: D6ZGP1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS02655
gene id: 548479:HMPREF0573_RS02655
uniprot id: D6ZJF3
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

548479:HMPREF0573 RS03670
gene id: 548479:HMPREF0573_RS03670
uniprot id: D6ZK13
names: Similarity
messages: Belongs to the GSP E family.

548479:HMPREF0573 RS03595
gene id: 548479:HMPREF0573_RS03595
uniprot id: D6ZJZ8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

548479:HMPREF0573 RS02890
gene id: 548479:HMPREF0573_RS02890
uniprot id: D6ZJK5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

548479:HMPREF0573 RS03765
gene id: 548479:HMPREF0573_RS03765
uniprot id: D6ZK34
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS06545
gene id: 548479:HMPREF0573_RS06545
uniprot id: D6ZGA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

548479:HMPREF0573 RS08205
gene id: 548479:HMPREF0573_RS08205
uniprot id: D6ZH89
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

548479:HMPREF0573 RS02110
gene id: 548479:HMPREF0573_RS02110
uniprot id: D6ZJ55
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS01845
gene id: 548479:HMPREF0573_RS01845
uniprot id: D6ZJ00
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

548479:HMPREF0573 RS06735
gene id: 548479:HMPREF0573_RS06735
uniprot id: D6ZGE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

548479:HMPREF0573 RS03930
gene id: 548479:HMPREF0573_RS03930
uniprot id: D6ZK67
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS00235
gene id: 548479:HMPREF0573_RS00235
uniprot id: D6ZI10
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

548479:HMPREF0573 RS04835
gene id: 548479:HMPREF0573_RS04835
uniprot id: D6ZKQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

548479:HMPREF0573 RS05005
gene id: 548479:HMPREF0573_RS05005
uniprot id: D6ZKT7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

548479:HMPREF0573 RS06940
gene id: 548479:HMPREF0573_RS06940
uniprot id: D6ZGI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

548479:HMPREF0573 RS06935
gene id: 548479:HMPREF0573_RS06935
uniprot id: D6ZGH9
names: Function
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.

548479:HMPREF0573 RS04850
gene id: 548479:HMPREF0573_RS04850
uniprot id: D6ZKQ6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

548479:HMPREF0573 RS05710
gene id: 548479:HMPREF0573_RS05710
uniprot id: D6ZL81
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS01885
gene id: 548479:HMPREF0573_RS01885
uniprot id: D6ZJ08
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS03255
gene id: 548479:HMPREF0573_RS03255
uniprot id: D6ZJS5
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

548479:HMPREF0573 RS03125
gene id: 548479:HMPREF0573_RS03125
uniprot id: D6ZJQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

548479:HMPREF0573 RS09035
gene id: 548479:HMPREF0573_RS09035
uniprot id: D6ZHQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

548479:HMPREF0573 RS01915
gene id: 548479:HMPREF0573_RS01915
uniprot id: D6ZJ15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

548479:HMPREF0573 RS05850
gene id: 548479:HMPREF0573_RS05850
uniprot id: D6ZFV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

548479:HMPREF0573 RS06695
gene id: 548479:HMPREF0573_RS06695
uniprot id: D6ZGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

548479:HMPREF0573 RS01670
gene id: 548479:HMPREF0573_RS01670
uniprot id: D6ZIW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

548479:HMPREF0573 RS03375
gene id: 548479:HMPREF0573_RS03375
uniprot id: D6ZJV0
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

548479:HMPREF0573 RS07880
gene id: 548479:HMPREF0573_RS07880
uniprot id: D6ZH23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

548479:HMPREF0573 RS03885
gene id: 548479:HMPREF0573_RS03885
uniprot id: D6ZK57
names: Similarity
messages: Belongs to the HupF/HypC family.

548479:HMPREF0573 RS09070
gene id: 548479:HMPREF0573_RS09070
uniprot id: D6ZHR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS04880
gene id: 548479:HMPREF0573_RS04880
uniprot id: D6ZKR3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

548479:HMPREF0573 RS03520
gene id: 548479:HMPREF0573_RS03520
uniprot id: D6ZJY2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

548479:HMPREF0573 RS03350
gene id: 548479:HMPREF0573_RS03350
uniprot id: D6ZJU4
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS07610
gene id: 548479:HMPREF0573_RS07610
uniprot id: D6ZGW9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

548479:HMPREF0573 RS01705
gene id: 548479:HMPREF0573_RS01705
uniprot id: D6ZIX1
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS02075
gene id: 548479:HMPREF0573_RS02075
uniprot id: D6ZJ47
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

548479:HMPREF0573 RS04775
gene id: 548479:HMPREF0573_RS04775
uniprot id: D6ZKN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

548479:HMPREF0573 RS01225
gene id: 548479:HMPREF0573_RS01225
uniprot id: D6ZIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS07520
gene id: 548479:HMPREF0573_RS07520
uniprot id: D6ZGV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

548479:HMPREF0573 RS04660
gene id: 548479:HMPREF0573_RS04660
uniprot id: D6ZKL6
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

548479:HMPREF0573 RS07745
gene id: 548479:HMPREF0573_RS07745
uniprot id: D6ZGZ6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

548479:HMPREF0573 RS00140
gene id: 548479:HMPREF0573_RS00140
uniprot id: D6ZHZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

548479:HMPREF0573 RS07330
gene id: 548479:HMPREF0573_RS07330
uniprot id: D6ZGR0
names: Similarity
messages: Belongs to the IMPACT family.

548479:HMPREF0573 RS00600
gene id: 548479:HMPREF0573_RS00600
uniprot id: D6ZI84
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

548479:HMPREF0573 RS05395
gene id: 548479:HMPREF0573_RS05395
uniprot id: D6ZL16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

548479:HMPREF0573 RS01585
gene id: 548479:HMPREF0573_RS01585
uniprot id: D6ZIU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

548479:HMPREF0573 RS03830
gene id: 548479:HMPREF0573_RS03830
uniprot id: D6ZK46
names: Similarity
messages: Belongs to the HupF/HypC family.

548479:HMPREF0573 RS01635
gene id: 548479:HMPREF0573_RS01635
uniprot id: D6ZIV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

548479:HMPREF0573 RS08135
gene id: 548479:HMPREF0573_RS08135
uniprot id: D6ZH75
names: Similarity
messages: Belongs to the peptidase S24 family.

548479:HMPREF0573 RS04420
gene id: 548479:HMPREF0573_RS04420
uniprot id: D6ZKG7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

548479:HMPREF0573 RS01135
gene id: 548479:HMPREF0573_RS01135
uniprot id: D6ZIJ6
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

548479:HMPREF0573 RS04425
gene id: 548479:HMPREF0573_RS04425
uniprot id: D6ZKG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

548479:HMPREF0573 RS05960
gene id: 548479:HMPREF0573_RS05960
uniprot id: D6ZFX4
names: Function
names: Similarity
messages: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

548479:HMPREF0573 RS04885
gene id: 548479:HMPREF0573_RS04885
uniprot id: D6ZKR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

548479:HMPREF0573 RS01645
gene id: 548479:HMPREF0573_RS01645
uniprot id: D6ZIV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

548479:HMPREF0573 RS04725
gene id: 548479:HMPREF0573_RS04725
uniprot id: D6ZKM8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

548479:HMPREF0573 RS01780
gene id: 548479:HMPREF0573_RS01780
uniprot id: D6ZIY7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

548479:HMPREF0573 RS08380
gene id: 548479:HMPREF0573_RS08380
uniprot id: D6ZHC5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS06265
gene id: 548479:HMPREF0573_RS06265
uniprot id: D6ZG41
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS05855
gene id: 548479:HMPREF0573_RS05855
uniprot id: D6ZFV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS05495
gene id: 548479:HMPREF0573_RS05495
uniprot id: D6ZL39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

548479:HMPREF0573 RS00535
gene id: 548479:HMPREF0573_RS00535
uniprot id: D6ZI71
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS04445
gene id: 548479:HMPREF0573_RS04445
uniprot id: D6ZKH2
names: Similarity
messages: In the C-terminal section; belongs to the NAD synthetase family.

548479:HMPREF0573 RS04415
gene id: 548479:HMPREF0573_RS04415
uniprot id: D6ZKG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

548479:HMPREF0573 RS08385
gene id: 548479:HMPREF0573_RS08385
uniprot id: D6ZHC6
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

548479:HMPREF0573 RS05195
gene id: 548479:HMPREF0573_RS05195
uniprot id: D6ZKX6
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

548479:HMPREF0573 RS07035
gene id: 548479:HMPREF0573_RS07035
uniprot id: D6ZGJ9
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS00040
gene id: 548479:HMPREF0573_RS00040
uniprot id: D6ZHX1
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

548479:HMPREF0573 RS05845
gene id: 548479:HMPREF0573_RS05845
uniprot id: D6ZFV0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

548479:HMPREF0573 RS07930
gene id: 548479:HMPREF0573_RS07930
uniprot id: D6ZH34
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

548479:HMPREF0573 RS07220
gene id: 548479:HMPREF0573_RS07220
uniprot id: D6ZGN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

548479:HMPREF0573 RS07315
gene id: 548479:HMPREF0573_RS07315
uniprot id: D6ZGQ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

548479:HMPREF0573 RS00175
gene id: 548479:HMPREF0573_RS00175
uniprot id: D6ZHZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

548479:HMPREF0573 RS07250
gene id: 548479:HMPREF0573_RS07250
uniprot id: D6ZGP4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

548479:HMPREF0573 RS08210
gene id: 548479:HMPREF0573_RS08210
uniprot id: D6ZH90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS07940
gene id: 548479:HMPREF0573_RS07940
uniprot id: D6ZH36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

548479:HMPREF0573 RS03905
gene id: 548479:HMPREF0573_RS03905
uniprot id: D6ZK61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

548479:HMPREF0573 RS03395
gene id: 548479:HMPREF0573_RS03395
uniprot id: D6ZJV4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

548479:HMPREF0573 RS01685
gene id: 548479:HMPREF0573_RS01685
uniprot id: D6ZIW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

548479:HMPREF0573 RS02470
gene id: 548479:HMPREF0573_RS02470
uniprot id: D6ZJB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

548479:HMPREF0573 RS00540
gene id: 548479:HMPREF0573_RS00540
uniprot id: D6ZI72
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS00210
gene id: 548479:HMPREF0573_RS00210
uniprot id: D6ZI05
names: Similarity
messages: Belongs to the peptidase C69 family.

548479:HMPREF0573 RS00565
gene id: 548479:HMPREF0573_RS00565
uniprot id: D6ZI77
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

548479:HMPREF0573 RS07945
gene id: 548479:HMPREF0573_RS07945
uniprot id: D6ZH37
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

548479:HMPREF0573 RS01895
gene id: 548479:HMPREF0573_RS01895
uniprot id: D6ZJ10
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

548479:HMPREF0573 RS06955
gene id: 548479:HMPREF0573_RS06955
uniprot id: D6ZGI3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

548479:HMPREF0573 RS00150
gene id: 548479:HMPREF0573_RS00150
uniprot id: D6ZHZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

548479:HMPREF0573 RS02965
gene id: 548479:HMPREF0573_RS02965
uniprot id: D6ZJL9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

548479:HMPREF0573 RS05425
gene id: 548479:HMPREF0573_RS05425
uniprot id: D6ZL22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

548479:HMPREF0573 RS04040
gene id: 548479:HMPREF0573_RS04040
uniprot id: D6ZK90
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

548479:HMPREF0573 RS08750
gene id: 548479:HMPREF0573_RS08750
uniprot id: D6ZHK1
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

548479:HMPREF0573 RS00700
gene id: 548479:HMPREF0573_RS00700
uniprot id: D6ZIA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

548479:HMPREF0573 RS06585
gene id: 548479:HMPREF0573_RS06585
uniprot id: D6ZGA9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

548479:HMPREF0573 RS01570
gene id: 548479:HMPREF0573_RS01570
uniprot id: D6ZIU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

548479:HMPREF0573 RS07300
gene id: 548479:HMPREF0573_RS07300
uniprot id: D6ZGQ4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS06910
gene id: 548479:HMPREF0573_RS06910
uniprot id: D6ZGH4
names: Similarity
messages: Belongs to the HSP15 family.

548479:HMPREF0573 RS02365
gene id: 548479:HMPREF0573_RS02365
uniprot id: D6ZJ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

548479:HMPREF0573 RS01470
gene id: 548479:HMPREF0573_RS01470
uniprot id: D6ZIS2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

548479:HMPREF0573 RS03950
gene id: 548479:HMPREF0573_RS03950
uniprot id: D6ZK71
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

548479:HMPREF0573 RS01675
gene id: 548479:HMPREF0573_RS01675
uniprot id: D6ZIW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

548479:HMPREF0573 RS05880
gene id: 548479:HMPREF0573_RS05880
uniprot id: D6ZFV7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS00825
gene id: 548479:HMPREF0573_RS00825
uniprot id: D6ZID6
names: Similarity
messages: Belongs to the LOG family.

548479:HMPREF0573 RS03960
gene id: 548479:HMPREF0573_RS03960
uniprot id: D6ZK74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

548479:HMPREF0573 RS00945
gene id: 548479:HMPREF0573_RS00945
uniprot id: D6ZIG0
names: Similarity
messages: Belongs to the disproportionating enzyme family.

548479:HMPREF0573 RS05765
gene id: 548479:HMPREF0573_RS05765
uniprot id: D6ZFT6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

548479:HMPREF0573 RS06715
gene id: 548479:HMPREF0573_RS06715
uniprot id: D6ZGD6
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

548479:HMPREF0573 RS07775
gene id: 548479:HMPREF0573_RS07775
uniprot id: D6ZH02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Cytoplasm
messages: Homotetramer.

548479:HMPREF0573 RS04950
gene id: 548479:HMPREF0573_RS04950
uniprot id: D6ZKS7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

548479:HMPREF0573 RS08850
gene id: 548479:HMPREF0573_RS08850
uniprot id: D6ZHM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane

548479:HMPREF0573 RS05045
gene id: 548479:HMPREF0573_RS05045
uniprot id: D6ZKU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

548479:HMPREF0573 RS05440
gene id: 548479:HMPREF0573_RS05440
uniprot id: D6ZL25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

548479:HMPREF0573 RS01665
gene id: 548479:HMPREF0573_RS01665
uniprot id: D6ZIW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

548479:HMPREF0573 RS00185
gene id: 548479:HMPREF0573_RS00185
uniprot id: D6ZI00
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

548479:HMPREF0573 RS06605
gene id: 548479:HMPREF0573_RS06605
uniprot id: D6ZGB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

548479:HMPREF0573 RS08540
gene id: 548479:HMPREF0573_RS08540
uniprot id: D6ZHF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

548479:HMPREF0573 RS08150
gene id: 548479:HMPREF0573_RS08150
uniprot id: D6ZH78
names: Similarity
messages: Belongs to the UPF0371 family.

548479:HMPREF0573 RS05630
gene id: 548479:HMPREF0573_RS05630
uniprot id: D6ZL66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

548479:HMPREF0573 RS00450
gene id: 548479:HMPREF0573_RS00450
uniprot id: D6ZI51
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS05235
gene id: 548479:HMPREF0573_RS05235
uniprot id: D6ZKY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS05320
gene id: 548479:HMPREF0573_RS05320
uniprot id: D6ZL01
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS06555
gene id: 548479:HMPREF0573_RS06555
uniprot id: D6ZGA3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

548479:HMPREF0573 RS02360
gene id: 548479:HMPREF0573_RS02360
uniprot id: D6ZJ97
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

548479:HMPREF0573 RS04320
gene id: 548479:HMPREF0573_RS04320
uniprot id: D6ZKE7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

548479:HMPREF0573 RS08195
gene id: 548479:HMPREF0573_RS08195
uniprot id: D6ZH86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

548479:HMPREF0573 RS08890
gene id: 548479:HMPREF0573_RS08890
uniprot id: D6ZHM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

548479:HMPREF0573 RS02225
gene id: 548479:HMPREF0573_RS02225
uniprot id: D6ZJ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

548479:HMPREF0573 RS08895
gene id: 548479:HMPREF0573_RS08895
uniprot id: D6ZHN0
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

548479:HMPREF0573 RS07020
gene id: 548479:HMPREF0573_RS07020
uniprot id: D6ZGJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

548479:HMPREF0573 RS01535
gene id: 548479:HMPREF0573_RS01535
uniprot id: D6ZIT7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

548479:HMPREF0573 RS01420
gene id: 548479:HMPREF0573_RS01420
uniprot id: D6ZIR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS08550
gene id: 548479:HMPREF0573_RS08550
uniprot id: D6ZHF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

548479:HMPREF0573 RS01680
gene id: 548479:HMPREF0573_RS01680
uniprot id: D6ZIW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

548479:HMPREF0573 RS01550
gene id: 548479:HMPREF0573_RS01550
uniprot id: D6ZIU0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

548479:HMPREF0573 RS01365
gene id: 548479:HMPREF0573_RS01365
uniprot id: D6ZIQ1
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

548479:HMPREF0573 RS01820
gene id: 548479:HMPREF0573_RS01820
uniprot id: D6ZIZ5
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS00845
gene id: 548479:HMPREF0573_RS00845
uniprot id: D6ZIE0
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

548479:HMPREF0573 RS01335
gene id: 548479:HMPREF0573_RS01335
uniprot id: D6ZIP5
names: Similarity
messages: Belongs to the prokaryotic ubiquitin-like protein family.

548479:HMPREF0573 RS00790
gene id: 548479:HMPREF0573_RS00790
uniprot id: D6ZIC8
names: Similarity
messages: Belongs to the DEAD box helicase family.

548479:HMPREF0573 RS01235
gene id: 548479:HMPREF0573_RS01235
uniprot id: D6ZIL7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

548479:HMPREF0573 RS03615
gene id: 548479:HMPREF0573_RS03615
uniprot id: D6ZK02
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

548479:HMPREF0573 RS01180
gene id: 548479:HMPREF0573_RS01180
uniprot id: D6ZIK6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

548479:HMPREF0573 RS09090
gene id: 548479:HMPREF0573_RS09090
uniprot id: D6ZHS0
names: Subcellular Location Annotation
messages: Cytoplasm

548479:HMPREF0573 RS05060
gene id: 548479:HMPREF0573_RS05060
uniprot id: D6ZKU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Membrane

548479:HMPREF0573 RS01835
gene id: 548479:HMPREF0573_RS01835
uniprot id: D6ZIZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

548479:HMPREF0573 RS08140
gene id: 548479:HMPREF0573_RS08140
uniprot id: D6ZH76
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

548479:HMPREF0573 RS04955
gene id: 548479:HMPREF0573_RS04955
uniprot id: D6ZKS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

548479:HMPREF0573 RS03010
gene id: 548479:HMPREF0573_RS03010
uniprot id: D6ZJM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

548479:HMPREF0573 RS03860
gene id: 548479:HMPREF0573_RS03860
uniprot id: D6ZK52
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

548479:HMPREF0573 RS04545
gene id: 548479:HMPREF0573_RS04545
uniprot id: D6ZKJ3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

548479:HMPREF0573 RS01650
gene id: 548479:HMPREF0573_RS01650
uniprot id: D6ZIW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

548479:HMPREF0573 RS09040
gene id: 548479:HMPREF0573_RS09040
uniprot id: D6ZHR0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

548479:HMPREF0573 RS01305
gene id: 548479:HMPREF0573_RS01305
uniprot id: D6ZIN9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

548479:HMPREF0573 RS00890
gene id: 548479:HMPREF0573_RS00890
uniprot id: D6ZIE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

548479:HMPREF0573 RS07375
gene id: 548479:HMPREF0573_RS07375
uniprot id: D6ZGR9
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS06510
gene id: 548479:HMPREF0573_RS06510
uniprot id: D6ZG94
names: Similarity
messages: Belongs to the peptidase S1 family.

548479:HMPREF0573 RS06385
gene id: 548479:HMPREF0573_RS06385
uniprot id: D6ZG68
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

548479:HMPREF0573 RS02430
gene id: 548479:HMPREF0573_RS02430
uniprot id: D6ZJA9
names: Similarity
messages: Belongs to the peptidase C40 family.

548479:HMPREF0573 RS00680
gene id: 548479:HMPREF0573_RS00680
uniprot id: D6ZIA3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

548479:HMPREF0573 RS08870
gene id: 548479:HMPREF0573_RS08870
uniprot id: D6ZHM5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS05745
gene id: 548479:HMPREF0573_RS05745
uniprot id: D6ZFT2
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

548479:HMPREF0573 RS08235
gene id: 548479:HMPREF0573_RS08235
uniprot id: D6ZH95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

548479:HMPREF0573 RS02765
gene id: 548479:HMPREF0573_RS02765
uniprot id: D6ZJH9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS04940
gene id: 548479:HMPREF0573_RS04940
uniprot id: D6ZKS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

548479:HMPREF0573 RS04210
gene id: 548479:HMPREF0573_RS04210
uniprot id: D6ZKC5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

548479:HMPREF0573 RS04315
gene id: 548479:HMPREF0573_RS04315
uniprot id: D6ZKE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

548479:HMPREF0573 RS08215
gene id: 548479:HMPREF0573_RS08215
uniprot id: D6ZH91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

548479:HMPREF0573 RS07215
gene id: 548479:HMPREF0573_RS07215
uniprot id: D6ZGN6
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

548479:HMPREF0573 RS00750
gene id: 548479:HMPREF0573_RS00750
uniprot id: D6ZIB9
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS05780
gene id: 548479:HMPREF0573_RS05780
uniprot id: D6ZFT9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS03510
gene id: 548479:HMPREF0573_RS03510
uniprot id: D6ZJY0
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS02575
gene id: 548479:HMPREF0573_RS02575
uniprot id: D6ZJD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

548479:HMPREF0573 RS05670
gene id: 548479:HMPREF0573_RS05670
uniprot id: D6ZL74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS02725
gene id: 548479:HMPREF0573_RS02725
uniprot id: D6ZJH0
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS03490
gene id: 548479:HMPREF0573_RS03490
uniprot id: D6ZJX6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

548479:HMPREF0573 RS01115
gene id: 548479:HMPREF0573_RS01115
uniprot id: D6ZIJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

548479:HMPREF0573 RS06975
gene id: 548479:HMPREF0573_RS06975
uniprot id: D6ZGI7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

548479:HMPREF0573 RS04490
gene id: 548479:HMPREF0573_RS04490
uniprot id: D6ZKI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

548479:HMPREF0573 RS07995
gene id: 548479:HMPREF0573_RS07995
uniprot id: D6ZH48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS01500
gene id: 548479:HMPREF0573_RS01500
uniprot id: D6ZIT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

548479:HMPREF0573 RS05750
gene id: 548479:HMPREF0573_RS05750
uniprot id: D6ZFT3
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

548479:HMPREF0573 RS00505
gene id: 548479:HMPREF0573_RS00505
uniprot id: D6ZI63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

548479:HMPREF0573 RS09300
gene id: 548479:HMPREF0573_RS09300
uniprot id: D6ZHW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

548479:HMPREF0573 RS05215
gene id: 548479:HMPREF0573_RS05215
uniprot id: D6ZKY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

548479:HMPREF0573 RS03480
gene id: 548479:HMPREF0573_RS03480
uniprot id: D6ZJX4
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS01785
gene id: 548479:HMPREF0573_RS01785
uniprot id: D6ZIY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

548479:HMPREF0573 RS07735
gene id: 548479:HMPREF0573_RS07735
uniprot id: D6ZGZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

548479:HMPREF0573 RS08415
gene id: 548479:HMPREF0573_RS08415
uniprot id: D6ZHD2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

548479:HMPREF0573 RS08555
gene id: 548479:HMPREF0573_RS08555
uniprot id: D6ZHG0
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

548479:HMPREF0573 RS00900
gene id: 548479:HMPREF0573_RS00900
uniprot id: D6ZIF1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

548479:HMPREF0573 RS06285
gene id: 548479:HMPREF0573_RS06285
uniprot id: D6ZG45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS01155
gene id: 548479:HMPREF0573_RS01155
uniprot id: D6ZIK1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

548479:HMPREF0573 RS06335
gene id: 548479:HMPREF0573_RS06335
uniprot id: D6ZG56
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS04280
gene id: 548479:HMPREF0573_RS04280
uniprot id: D6ZKD9
names: Similarity
messages: Belongs to the peptidase C40 family.

548479:HMPREF0573 RS07320
gene id: 548479:HMPREF0573_RS07320
uniprot id: D6ZGQ8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

548479:HMPREF0573 RS07470
gene id: 548479:HMPREF0573_RS07470
uniprot id: D6ZGU1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

548479:HMPREF0573 RS06370
gene id: 548479:HMPREF0573_RS06370
uniprot id: D6ZG65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

548479:HMPREF0573 RS09005
gene id: 548479:HMPREF0573_RS09005
uniprot id: D6ZHQ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

548479:HMPREF0573 RS04930
gene id: 548479:HMPREF0573_RS04930
uniprot id: D6ZKS3
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS09295
gene id: 548479:HMPREF0573_RS09295
uniprot id: D6ZHW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

548479:HMPREF0573 RS02770
gene id: 548479:HMPREF0573_RS02770
uniprot id: D6ZJI0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

548479:HMPREF0573 RS05200
gene id: 548479:HMPREF0573_RS05200
uniprot id: D6ZKX7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

548479:HMPREF0573 RS06570
gene id: 548479:HMPREF0573_RS06570
uniprot id: D6ZGA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

548479:HMPREF0573 RS00580
gene id: 548479:HMPREF0573_RS00580
uniprot id: D6ZI80
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

548479:HMPREF0573 RS07955
gene id: 548479:HMPREF0573_RS07955
uniprot id: D6ZH39
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS06530
gene id: 548479:HMPREF0573_RS06530
uniprot id: D6ZG98
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

548479:HMPREF0573 RS03105
gene id: 548479:HMPREF0573_RS03105
uniprot id: D6ZJP8
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

548479:HMPREF0573 RS08230
gene id: 548479:HMPREF0573_RS08230
uniprot id: D6ZH94
names: Similarity
messages: Belongs to the YciI family.

548479:HMPREF0573 RS04310
gene id: 548479:HMPREF0573_RS04310
uniprot id: D6ZKE5
names: Similarity
messages: Belongs to the MotB family.

548479:HMPREF0573 RS07095
gene id: 548479:HMPREF0573_RS07095
uniprot id: D6ZGL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

548479:HMPREF0573 RS01480
gene id: 548479:HMPREF0573_RS01480
uniprot id: D6ZIS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

548479:HMPREF0573 RS06980
gene id: 548479:HMPREF0573_RS06980
uniprot id: D6ZGI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

548479:HMPREF0573 RS07630
gene id: 548479:HMPREF0573_RS07630
uniprot id: D6ZGX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

548479:HMPREF0573 RS08885
gene id: 548479:HMPREF0573_RS08885
uniprot id: D6ZHM8
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

548479:HMPREF0573 RS07870
gene id: 548479:HMPREF0573_RS07870
uniprot id: D6ZH21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

548479:HMPREF0573 RS04890
gene id: 548479:HMPREF0573_RS04890
uniprot id: D6ZKR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

548479:HMPREF0573 RS06920
gene id: 548479:HMPREF0573_RS06920
uniprot id: D6ZGH6
names: Similarity
messages: Belongs to the peptidase M16 family.

548479:HMPREF0573 RS01425
gene id: 548479:HMPREF0573_RS01425
uniprot id: D6ZIR3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

548479:HMPREF0573 RS06410
gene id: 548479:HMPREF0573_RS06410
uniprot id: D6ZG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS08335
gene id: 548479:HMPREF0573_RS08335
uniprot id: D6ZHB5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

548479:HMPREF0573 RS03290
gene id: 548479:HMPREF0573_RS03290
uniprot id: D6ZJT3
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS01450
gene id: 548479:HMPREF0573_RS01450
uniprot id: D6ZIR8
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

548479:HMPREF0573 RS07715
gene id: 548479:HMPREF0573_RS07715
uniprot id: D6ZGZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

548479:HMPREF0573 RS04570
gene id: 548479:HMPREF0573_RS04570
uniprot id: D6ZKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

548479:HMPREF0573 RS09125
gene id: 548479:HMPREF0573_RS09125
uniprot id: D6ZHS7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

548479:HMPREF0573 RS04530
gene id: 548479:HMPREF0573_RS04530
uniprot id: D6ZKJ0
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS07135
gene id: 548479:HMPREF0573_RS07135
uniprot id: D6ZGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

548479:HMPREF0573 RS05635
gene id: 548479:HMPREF0573_RS05635
uniprot id: D6ZL67
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

548479:HMPREF0573 RS02660
gene id: 548479:HMPREF0573_RS02660
uniprot id: D6ZJF4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

548479:HMPREF0573 RS03425
gene id: 548479:HMPREF0573_RS03425
uniprot id: D6ZJW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

548479:HMPREF0573 RS00520
gene id: 548479:HMPREF0573_RS00520
uniprot id: D6ZI67
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

548479:HMPREF0573 RS05820
gene id: 548479:HMPREF0573_RS05820
uniprot id: D6ZFU7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS03100
gene id: 548479:HMPREF0573_RS03100
uniprot id: D6ZJP7
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

548479:HMPREF0573 RS08570
gene id: 548479:HMPREF0573_RS08570
uniprot id: D6ZHG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

548479:HMPREF0573 RS07225
gene id: 548479:HMPREF0573_RS07225
uniprot id: D6ZGN9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

548479:HMPREF0573 RS01360
gene id: 548479:HMPREF0573_RS01360
uniprot id: D6ZIQ0
names: Similarity
messages: Belongs to the amidinotransferase family.

548479:HMPREF0573 RS01145
gene id: 548479:HMPREF0573_RS01145
uniprot id: D6ZIJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

548479:HMPREF0573 RS03620
gene id: 548479:HMPREF0573_RS03620
uniprot id: D6ZK03
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

548479:HMPREF0573 RS09015
gene id: 548479:HMPREF0573_RS09015
uniprot id: D6ZHQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

548479:HMPREF0573 RS06490
gene id: 548479:HMPREF0573_RS06490
uniprot id: D6ZG90
names: Similarity
messages: Belongs to the UPF0102 family.

548479:HMPREF0573 RS06065
gene id: 548479:HMPREF0573_RS06065
uniprot id: D6ZFZ9
names: Similarity
messages: Belongs to the peptidase S14 family.

548479:HMPREF0573 RS01750
gene id: 548479:HMPREF0573_RS01750
uniprot id: D6ZIY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.

548479:HMPREF0573 RS04715
gene id: 548479:HMPREF0573_RS04715
uniprot id: D6ZKM6
names: Similarity
messages: Belongs to the citrate synthase family.

548479:HMPREF0573 RS00840
gene id: 548479:HMPREF0573_RS00840
uniprot id: D6ZID9
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS01575
gene id: 548479:HMPREF0573_RS01575
uniprot id: D6ZIU5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

548479:HMPREF0573 RS00870
gene id: 548479:HMPREF0573_RS00870
uniprot id: D6ZIE5
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

548479:HMPREF0573 RS01530
gene id: 548479:HMPREF0573_RS01530
uniprot id: D6ZIT6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

548479:HMPREF0573 RS08945
gene id: 548479:HMPREF0573_RS08945
uniprot id: D6ZHP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

548479:HMPREF0573 RS03065
gene id: 548479:HMPREF0573_RS03065
uniprot id: D6ZJP0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

548479:HMPREF0573 RS01880
gene id: 548479:HMPREF0573_RS01880
uniprot id: D6ZJ07
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS04960
gene id: 548479:HMPREF0573_RS04960
uniprot id: D6ZKS9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS07555
gene id: 548479:HMPREF0573_RS07555
uniprot id: D6ZGV8
names: Similarity
messages: Belongs to the peptidase S33 family.

548479:HMPREF0573 RS04750
gene id: 548479:HMPREF0573_RS04750
uniprot id: D6ZKN4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

548479:HMPREF0573 RS03845
gene id: 548479:HMPREF0573_RS03845
uniprot id: D6ZK49
names: Similarity
messages: Belongs to the peptidase A31 family.

548479:HMPREF0573 RS07025
gene id: 548479:HMPREF0573_RS07025
uniprot id: D6ZGJ7
names: Similarity
messages: Belongs to the UPF0423 family.

548479:HMPREF0573 RS04255
gene id: 548479:HMPREF0573_RS04255
uniprot id: D6ZKD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

548479:HMPREF0573 RS04000
gene id: 548479:HMPREF0573_RS04000
uniprot id: D6ZK82
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS08305
gene id: 548479:HMPREF0573_RS08305
uniprot id: D6ZHA9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

548479:HMPREF0573 RS08655
gene id: 548479:HMPREF0573_RS08655
uniprot id: D6ZHI0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

548479:HMPREF0573 RS07800
gene id: 548479:HMPREF0573_RS07800
uniprot id: D6ZH07
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

548479:HMPREF0573 RS02970
gene id: 548479:HMPREF0573_RS02970
uniprot id: D6ZJM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

548479:HMPREF0573 RS02240
gene id: 548479:HMPREF0573_RS02240
uniprot id: D6ZJ78
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

548479:HMPREF0573 RS09275
gene id: 548479:HMPREF0573_RS09275
uniprot id: D6ZHV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

548479:HMPREF0573 RS06740
gene id: 548479:HMPREF0573_RS06740
uniprot id: D6ZGE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

548479:HMPREF0573 RS02275
gene id: 548479:HMPREF0573_RS02275
uniprot id: D6ZJ84
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

548479:HMPREF0573 RS04615
gene id: 548479:HMPREF0573_RS04615
uniprot id: D6ZKK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS03050
gene id: 548479:HMPREF0573_RS03050
uniprot id: D6ZJN7
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS03815
gene id: 548479:HMPREF0573_RS03815
uniprot id: D6ZK43
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

548479:HMPREF0573 RS08845
gene id: 548479:HMPREF0573_RS08845
uniprot id: D6ZHM0
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

548479:HMPREF0573 RS09050
gene id: 548479:HMPREF0573_RS09050
uniprot id: D6ZHR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

548479:HMPREF0573 RS04645
gene id: 548479:HMPREF0573_RS04645
uniprot id: D6ZKL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

548479:HMPREF0573 RS01075
gene id: 548479:HMPREF0573_RS01075
uniprot id: D6ZII4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

548479:HMPREF0573 RS07640
gene id: 548479:HMPREF0573_RS07640
uniprot id: D6ZGX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

548479:HMPREF0573 RS00650
gene id: 548479:HMPREF0573_RS00650
uniprot id: D6ZI96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

548479:HMPREF0573 RS05385
gene id: 548479:HMPREF0573_RS05385
uniprot id: D6ZL14
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS00075
gene id: 548479:HMPREF0573_RS00075
uniprot id: D6ZHX8
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

548479:HMPREF0573 RS07785
gene id: 548479:HMPREF0573_RS07785
uniprot id: D6ZH04
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

548479:HMPREF0573 RS04340
gene id: 548479:HMPREF0573_RS04340
uniprot id: D6ZKF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Membrane

548479:HMPREF0573 RS01790
gene id: 548479:HMPREF0573_RS01790
uniprot id: D6ZIY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

548479:HMPREF0573 RS07280
gene id: 548479:HMPREF0573_RS07280
uniprot id: D6ZGQ0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS04430
gene id: 548479:HMPREF0573_RS04430
uniprot id: D6ZKG9
names: Subcellular Location Annotation
messages: Cytoplasm

548479:HMPREF0573 RS05345
gene id: 548479:HMPREF0573_RS05345
uniprot id: D6ZL06
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

548479:HMPREF0573 RS07790
gene id: 548479:HMPREF0573_RS07790
uniprot id: D6ZH05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS07090
gene id: 548479:HMPREF0573_RS07090
uniprot id: D6ZGL0
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS06500
gene id: 548479:HMPREF0573_RS06500
uniprot id: D6ZG92
names: Similarity
messages: Belongs to the DprA/Smf family.

548479:HMPREF0573 RS02555
gene id: 548479:HMPREF0573_RS02555
uniprot id: D6ZJD4
names: Similarity
messages: Belongs to the WXG100 family.

548479:HMPREF0573 RS04055
gene id: 548479:HMPREF0573_RS04055
uniprot id: D6ZK93
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

548479:HMPREF0573 RS07100
gene id: 548479:HMPREF0573_RS07100
uniprot id: D6ZGL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

548479:HMPREF0573 RS04355
gene id: 548479:HMPREF0573_RS04355
uniprot id: D6ZKF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

548479:HMPREF0573 RS02990
gene id: 548479:HMPREF0573_RS02990
uniprot id: D6ZJM4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

548479:HMPREF0573 RS02445
gene id: 548479:HMPREF0573_RS02445
uniprot id: D6ZJB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

548479:HMPREF0573 RS00165
gene id: 548479:HMPREF0573_RS00165
uniprot id: D6ZHZ6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

548479:HMPREF0573 RS04380
gene id: 548479:HMPREF0573_RS04380
uniprot id: D6ZKF9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

548479:HMPREF0573 RS01005
gene id: 548479:HMPREF0573_RS01005
uniprot id: D6ZIH0
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

548479:HMPREF0573 RS00585
gene id: 548479:HMPREF0573_RS00585
uniprot id: D6ZI81
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

548479:HMPREF0573 RS01095
gene id: 548479:HMPREF0573_RS01095
uniprot id: D6ZII8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS00925
gene id: 548479:HMPREF0573_RS00925
uniprot id: D6ZIF6
names: Similarity
messages: Belongs to the peptidase M13 family.

548479:HMPREF0573 RS00625
gene id: 548479:HMPREF0573_RS00625
uniprot id: D6ZI90
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS09055
gene id: 548479:HMPREF0573_RS09055
uniprot id: D6ZHR3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

548479:HMPREF0573 RS04240
gene id: 548479:HMPREF0573_RS04240
uniprot id: D6ZKD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

548479:HMPREF0573 RS04270
gene id: 548479:HMPREF0573_RS04270
uniprot id: D6ZKD7
names: Subcellular Location Annotation
messages: Cytoplasm

548479:HMPREF0573 RS00905
gene id: 548479:HMPREF0573_RS00905
uniprot id: D6ZIF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

548479:HMPREF0573 RS08085
gene id: 548479:HMPREF0573_RS08085
uniprot id: D6ZH65
names: Similarity
messages: Belongs to the AAA ATPase family.

548479:HMPREF0573 RS07935
gene id: 548479:HMPREF0573_RS07935
uniprot id: D6ZH35
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

548479:HMPREF0573 RS09290
gene id: 548479:HMPREF0573_RS09290
uniprot id: D6ZHW2
names: Similarity
messages: Belongs to the carbamate kinase family.

548479:HMPREF0573 RS09375
gene id: 548479:HMPREF0573_RS09375
uniprot id: D6ZJW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

548479:HMPREF0573 RS09305
gene id: 548479:HMPREF0573_RS09305
uniprot id: D6ZHW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

548479:HMPREF0573 RS08545
gene id: 548479:HMPREF0573_RS08545
uniprot id: D6ZHF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

548479:HMPREF0573 RS06705
gene id: 548479:HMPREF0573_RS06705
uniprot id: D6ZGD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

548479:HMPREF0573 RS06960
gene id: 548479:HMPREF0573_RS06960
uniprot id: D6ZGI4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

548479:HMPREF0573 RS00060
gene id: 548479:HMPREF0573_RS00060
uniprot id: D6ZHX5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

548479:HMPREF0573 RS08940
gene id: 548479:HMPREF0573_RS08940
uniprot id: D6ZHP0
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

548479:HMPREF0573 RS00660
gene id: 548479:HMPREF0573_RS00660
uniprot id: D6ZI99
names: Similarity
messages: Belongs to the ribF family.

548479:HMPREF0573 RS02940
gene id: 548479:HMPREF0573_RS02940
uniprot id: D6ZJL5
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS07120
gene id: 548479:HMPREF0573_RS07120
uniprot id: D6ZGL7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

548479:HMPREF0573 RS07865
gene id: 548479:HMPREF0573_RS07865
uniprot id: D6ZH20
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

548479:HMPREF0573 RS01815
gene id: 548479:HMPREF0573_RS01815
uniprot id: D6ZIZ4
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS02265
gene id: 548479:HMPREF0573_RS02265
uniprot id: D6ZJ82
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

548479:HMPREF0573 RS02235
gene id: 548479:HMPREF0573_RS02235
uniprot id: D6ZJ76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

548479:HMPREF0573 RS07055
gene id: 548479:HMPREF0573_RS07055
uniprot id: D6ZGK3
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.

548479:HMPREF0573 RS02290
gene id: 548479:HMPREF0573_RS02290
uniprot id: D6ZJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Cell membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

548479:HMPREF0573 RS03155
gene id: 548479:HMPREF0573_RS03155
uniprot id: D6ZJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS00090
gene id: 548479:HMPREF0573_RS00090
uniprot id: D6ZHY1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

548479:HMPREF0573 RS02565
gene id: 548479:HMPREF0573_RS02565
uniprot id: D6ZJD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

548479:HMPREF0573 RS05000
gene id: 548479:HMPREF0573_RS05000
uniprot id: D6ZKT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

548479:HMPREF0573 RS00065
gene id: 548479:HMPREF0573_RS00065
uniprot id: D6ZHX6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

548479:HMPREF0573 RS07275
gene id: 548479:HMPREF0573_RS07275
uniprot id: D6ZGP9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS00995
gene id: 548479:HMPREF0573_RS00995
uniprot id: D6ZIG8
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS03975
gene id: 548479:HMPREF0573_RS03975
uniprot id: D6ZK77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS03590
gene id: 548479:HMPREF0573_RS03590
uniprot id: D6ZJZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS08790
gene id: 548479:HMPREF0573_RS08790
uniprot id: D6ZHK9
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

548479:HMPREF0573 RS00115
gene id: 548479:HMPREF0573_RS00115
uniprot id: D6ZHY6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

548479:HMPREF0573 RS00670
gene id: 548479:HMPREF0573_RS00670
uniprot id: D6ZIA1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

548479:HMPREF0573 RS07795
gene id: 548479:HMPREF0573_RS07795
uniprot id: D6ZH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS00460
gene id: 548479:HMPREF0573_RS00460
uniprot id: D6ZI53
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

548479:HMPREF0573 RS08365
gene id: 548479:HMPREF0573_RS08365
uniprot id: D6ZHC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

548479:HMPREF0573 RS07750
gene id: 548479:HMPREF0573_RS07750
uniprot id: D6ZGZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

548479:HMPREF0573 RS05550
gene id: 548479:HMPREF0573_RS05550
uniprot id: D6ZL53
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.

548479:HMPREF0573 RS07140
gene id: 548479:HMPREF0573_RS07140
uniprot id: D6ZGM1
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

548479:HMPREF0573 RS06375
gene id: 548479:HMPREF0573_RS06375
uniprot id: D6ZG66
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

548479:HMPREF0573 RS05485
gene id: 548479:HMPREF0573_RS05485
uniprot id: D6ZL36
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS08875
gene id: 548479:HMPREF0573_RS08875
uniprot id: D6ZHM6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS04745
gene id: 548479:HMPREF0573_RS04745
uniprot id: D6ZKN3
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

548479:HMPREF0573 RS00690
gene id: 548479:HMPREF0573_RS00690
uniprot id: D6ZIA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

548479:HMPREF0573 RS07490
gene id: 548479:HMPREF0573_RS07490
uniprot id: D6ZGU5
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

548479:HMPREF0573 RS00145
gene id: 548479:HMPREF0573_RS00145
uniprot id: D6ZHZ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS04510
gene id: 548479:HMPREF0573_RS04510
uniprot id: D6ZKI6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

548479:HMPREF0573 RS01430
gene id: 548479:HMPREF0573_RS01430
uniprot id: D6ZIR4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

548479:HMPREF0573 RS07720
gene id: 548479:HMPREF0573_RS07720
uniprot id: D6ZGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

548479:HMPREF0573 RS04700
gene id: 548479:HMPREF0573_RS04700
uniprot id: D6ZKM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

548479:HMPREF0573 RS04325
gene id: 548479:HMPREF0573_RS04325
uniprot id: D6ZKE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

548479:HMPREF0573 RS05135
gene id: 548479:HMPREF0573_RS05135
uniprot id: D6ZKW4
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

548479:HMPREF0573 RS04640
gene id: 548479:HMPREF0573_RS04640
uniprot id: D6ZKL1
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

548479:HMPREF0573 RS09060
gene id: 548479:HMPREF0573_RS09060
uniprot id: D6ZHR4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS08530
gene id: 548479:HMPREF0573_RS08530
uniprot id: D6ZHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

548479:HMPREF0573 RS07440
gene id: 548479:HMPREF0573_RS07440
uniprot id: D6ZGT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

548479:HMPREF0573 RS09260
gene id: 548479:HMPREF0573_RS09260
uniprot id: D6ZHV4
names: Similarity
messages: Belongs to the TlyA family.

548479:HMPREF0573 RS08985
gene id: 548479:HMPREF0573_RS08985
uniprot id: D6ZHP9
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

548479:HMPREF0573 RS02120
gene id: 548479:HMPREF0573_RS02120
uniprot id: D6ZJ57
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

548479:HMPREF0573 RS05680
gene id: 548479:HMPREF0573_RS05680
uniprot id: D6ZL76
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

548479:HMPREF0573 RS01770
gene id: 548479:HMPREF0573_RS01770
uniprot id: D6ZIY5
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
messages: In the N-terminal section; belongs to the DHNA family.

548479:HMPREF0573 RS05055
gene id: 548479:HMPREF0573_RS05055
uniprot id: D6ZKU7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS00050
gene id: 548479:HMPREF0573_RS00050
uniprot id: D6ZHX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

548479:HMPREF0573 RS03420
gene id: 548479:HMPREF0573_RS03420
uniprot id: D6ZJW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

548479:HMPREF0573 RS02435
gene id: 548479:HMPREF0573_RS02435
uniprot id: D6ZJB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

548479:HMPREF0573 RS09110
gene id: 548479:HMPREF0573_RS09110
uniprot id: D6ZHS4
names: Similarity
messages: Belongs to the YggT family.

548479:HMPREF0573 RS01205
gene id: 548479:HMPREF0573_RS01205
uniprot id: D6ZIL1
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS02250
gene id: 548479:HMPREF0573_RS02250
uniprot id: D6ZJ80
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS08445
gene id: 548479:HMPREF0573_RS08445
uniprot id: D6ZHD8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

548479:HMPREF0573 RS06115
gene id: 548479:HMPREF0573_RS06115
uniprot id: D6ZG09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Cytoplasm
messages: Homotetramer.

548479:HMPREF0573 RS06475
gene id: 548479:HMPREF0573_RS06475
uniprot id: D6ZG87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

548479:HMPREF0573 RS00965
gene id: 548479:HMPREF0573_RS00965
uniprot id: D6ZIG3
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

548479:HMPREF0573 RS03465
gene id: 548479:HMPREF0573_RS03465
uniprot id: D6ZJX1
names: Similarity
messages: Belongs to the thioredoxin family.

548479:HMPREF0573 RS01320
gene id: 548479:HMPREF0573_RS01320
uniprot id: D6ZIP2
names: Similarity
messages: Belongs to the MEMO1 family.

548479:HMPREF0573 RS03890
gene id: 548479:HMPREF0573_RS03890
uniprot id: D6ZK58
names: Similarity
messages: Belongs to the HypD family.

548479:HMPREF0573 RS04515
gene id: 548479:HMPREF0573_RS04515
uniprot id: D6ZKI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

548479:HMPREF0573 RS07075
gene id: 548479:HMPREF0573_RS07075
uniprot id: D6ZGK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS07295
gene id: 548479:HMPREF0573_RS07295
uniprot id: D6ZGQ3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS07230
gene id: 548479:HMPREF0573_RS07230
uniprot id: D6ZGP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

548479:HMPREF0573 RS08325
gene id: 548479:HMPREF0573_RS08325
uniprot id: D6ZHB3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

548479:HMPREF0573 RS09095
gene id: 548479:HMPREF0573_RS09095
uniprot id: D6ZHS1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

548479:HMPREF0573 RS07325
gene id: 548479:HMPREF0573_RS07325
uniprot id: D6ZGQ9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

548479:HMPREF0573 RS02700
gene id: 548479:HMPREF0573_RS02700
uniprot id: D6ZJG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

548479:HMPREF0573 RS06565
gene id: 548479:HMPREF0573_RS06565
uniprot id: D6ZGA5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS06460
gene id: 548479:HMPREF0573_RS06460
uniprot id: D6ZG84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

548479:HMPREF0573 RS04440
gene id: 548479:HMPREF0573_RS04440
uniprot id: D6ZKH1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

548479:HMPREF0573 RS01555
gene id: 548479:HMPREF0573_RS01555
uniprot id: D6ZIU1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

548479:HMPREF0573 RS07725
gene id: 548479:HMPREF0573_RS07725
uniprot id: D6ZGZ2
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS00485
gene id: 548479:HMPREF0573_RS00485
uniprot id: D6ZI58
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

548479:HMPREF0573 RS06725
gene id: 548479:HMPREF0573_RS06725
uniprot id: D6ZGD8
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS08880
gene id: 548479:HMPREF0573_RS08880
uniprot id: D6ZHM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

548479:HMPREF0573 RS09100
gene id: 548479:HMPREF0573_RS09100
uniprot id: D6ZHS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

548479:HMPREF0573 RS00155
gene id: 548479:HMPREF0573_RS00155
uniprot id: D6ZHZ4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

548479:HMPREF0573 RS01800
gene id: 548479:HMPREF0573_RS01800
uniprot id: D6ZIZ1
names: Similarity
messages: Belongs to the peptidase C40 family.

548479:HMPREF0573 RS04985
gene id: 548479:HMPREF0573_RS04985
uniprot id: D6ZKT3
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS04290
gene id: 548479:HMPREF0573_RS04290
uniprot id: D6ZKE1
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

548479:HMPREF0573 RS05400
gene id: 548479:HMPREF0573_RS05400
uniprot id: D6ZL17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

548479:HMPREF0573 RS03435
gene id: 548479:HMPREF0573_RS03435
uniprot id: D6ZJW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

548479:HMPREF0573 RS07575
gene id: 548479:HMPREF0573_RS07575
uniprot id: D6ZGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS02985
gene id: 548479:HMPREF0573_RS02985
uniprot id: D6ZJM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

548479:HMPREF0573 RS00745
gene id: 548479:HMPREF0573_RS00745
uniprot id: D6ZIB8
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS05250
gene id: 548479:HMPREF0573_RS05250
uniprot id: D6ZKY7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

548479:HMPREF0573 RS02350
gene id: 548479:HMPREF0573_RS02350
uniprot id: D6ZJ95
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

548479:HMPREF0573 RS05590
gene id: 548479:HMPREF0573_RS05590
uniprot id: D6ZL59
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

548479:HMPREF0573 RS02050
gene id: 548479:HMPREF0573_RS02050
uniprot id: D6ZJ42
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

548479:HMPREF0573 RS07730
gene id: 548479:HMPREF0573_RS07730
uniprot id: D6ZGZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS01285
gene id: 548479:HMPREF0573_RS01285
uniprot id: D6ZIN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

548479:HMPREF0573 RS02580
gene id: 548479:HMPREF0573_RS02580
uniprot id: D6ZJD9
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

548479:HMPREF0573 RS05300
gene id: 548479:HMPREF0573_RS05300
uniprot id: D6ZKZ7
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

548479:HMPREF0573 RS08565
gene id: 548479:HMPREF0573_RS08565
uniprot id: D6ZHG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

548479:HMPREF0573 RS01545
gene id: 548479:HMPREF0573_RS01545
uniprot id: D6ZIT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

548479:HMPREF0573 RS04295
gene id: 548479:HMPREF0573_RS04295
uniprot id: D6ZKE2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

548479:HMPREF0573 RS04245
gene id: 548479:HMPREF0573_RS04245
uniprot id: D6ZKD2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

548479:HMPREF0573 RS05825
gene id: 548479:HMPREF0573_RS05825
uniprot id: D6ZFU8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS02520
gene id: 548479:HMPREF0573_RS02520
uniprot id: D6ZJC7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

548479:HMPREF0573 RS03240
gene id: 548479:HMPREF0573_RS03240
uniprot id: D6ZJS2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

548479:HMPREF0573 RS08515
gene id: 548479:HMPREF0573_RS08515
uniprot id: D6ZHF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

548479:HMPREF0573 RS03455
gene id: 548479:HMPREF0573_RS03455
uniprot id: D6ZJW8
names: Similarity
messages: Belongs to the ParB family.

548479:HMPREF0573 RS07170
gene id: 548479:HMPREF0573_RS07170
uniprot id: D6ZGM7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

548479:HMPREF0573 RS07960
gene id: 548479:HMPREF0573_RS07960
uniprot id: D6ZH40
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

548479:HMPREF0573 RS09245
gene id: 548479:HMPREF0573_RS09245
uniprot id: D6ZHV1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

548479:HMPREF0573 RS02495
gene id: 548479:HMPREF0573_RS02495
uniprot id: D6ZJC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

548479:HMPREF0573 RS01565
gene id: 548479:HMPREF0573_RS01565
uniprot id: D6ZIU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

548479:HMPREF0573 RS02630
gene id: 548479:HMPREF0573_RS02630
uniprot id: D6ZJE8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

548479:HMPREF0573 RS05030
gene id: 548479:HMPREF0573_RS05030
uniprot id: D6ZKU2
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

548479:HMPREF0573 RS02105
gene id: 548479:HMPREF0573_RS02105
uniprot id: D6ZJ54
names: Similarity
messages: Belongs to the PhoU family.
messages: Belongs to the UPF0111 family.

548479:HMPREF0573 RS04050
gene id: 548479:HMPREF0573_RS04050
uniprot id: D6ZK92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

548479:HMPREF0573 RS05405
gene id: 548479:HMPREF0573_RS05405
uniprot id: D6ZL18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

548479:HMPREF0573 RS08095
gene id: 548479:HMPREF0573_RS08095
uniprot id: D6ZH67
names: Similarity
messages: Belongs to the prokaryotic ubiquitin-like protein family.

548479:HMPREF0573 RS07855
gene id: 548479:HMPREF0573_RS07855
uniprot id: D6ZH18
names: Similarity
messages: Belongs to the peptidase M17 family.

548479:HMPREF0573 RS06470
gene id: 548479:HMPREF0573_RS06470
uniprot id: D6ZG86
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

548479:HMPREF0573 RS07345
gene id: 548479:HMPREF0573_RS07345
uniprot id: D6ZGR3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

548479:HMPREF0573 RS06730
gene id: 548479:HMPREF0573_RS06730
uniprot id: D6ZGD9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

548479:HMPREF0573 RS00950
gene id: 548479:HMPREF0573_RS00950
uniprot id: D6ZIG1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

548479:HMPREF0573 RS05990
gene id: 548479:HMPREF0573_RS05990
uniprot id: D6ZFY4
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS05065
gene id: 548479:HMPREF0573_RS05065
uniprot id: D6ZKU9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

548479:HMPREF0573 RS01660
gene id: 548479:HMPREF0573_RS01660
uniprot id: D6ZIW2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

548479:HMPREF0573 RS03195
gene id: 548479:HMPREF0573_RS03195
uniprot id: D6ZJR3
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS04165
gene id: 548479:HMPREF0573_RS04165
uniprot id: D6ZKB6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS07010
gene id: 548479:HMPREF0573_RS07010
uniprot id: D6ZGJ4
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS03380
gene id: 548479:HMPREF0573_RS03380
uniprot id: D6ZJV1
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS00255
gene id: 548479:HMPREF0573_RS00255
uniprot id: D6ZI14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

548479:HMPREF0573 RS06435
gene id: 548479:HMPREF0573_RS06435
uniprot id: D6ZG79
names: Similarity
messages: Belongs to the peptidase S51 family.

548479:HMPREF0573 RS08520
gene id: 548479:HMPREF0573_RS08520
uniprot id: D6ZHF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

548479:HMPREF0573 RS02735
gene id: 548479:HMPREF0573_RS02735
uniprot id: D6ZJH3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

548479:HMPREF0573 RS01925
gene id: 548479:HMPREF0573_RS01925
uniprot id: D6ZJ17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

548479:HMPREF0573 RS01795
gene id: 548479:HMPREF0573_RS01795
uniprot id: D6ZIZ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

548479:HMPREF0573 RS07560
gene id: 548479:HMPREF0573_RS07560
uniprot id: D6ZGV9
names: Similarity
messages: Belongs to the Fur family.

548479:HMPREF0573 RS02395
gene id: 548479:HMPREF0573_RS02395
uniprot id: D6ZJA3
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

548479:HMPREF0573 RS01590
gene id: 548479:HMPREF0573_RS01590
uniprot id: D6ZIU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

548479:HMPREF0573 RS01085
gene id: 548479:HMPREF0573_RS01085
uniprot id: D6ZII6
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

548479:HMPREF0573 RS08200
gene id: 548479:HMPREF0573_RS08200
uniprot id: D6ZH87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

548479:HMPREF0573 RS01350
gene id: 548479:HMPREF0573_RS01350
uniprot id: D6ZIP8
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS08585
gene id: 548479:HMPREF0573_RS08585
uniprot id: D6ZHG6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS01890
gene id: 548479:HMPREF0573_RS01890
uniprot id: D6ZJ09
names: Subcellular Location Annotation
messages: Membrane

548479:HMPREF0573 RS06540
gene id: 548479:HMPREF0573_RS06540
uniprot id: D6ZGA0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

548479:HMPREF0573 RS03330
gene id: 548479:HMPREF0573_RS03330
uniprot id: D6ZJU0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

548479:HMPREF0573 RS00755
gene id: 548479:HMPREF0573_RS00755
uniprot id: D6ZIC0
names: Similarity
messages: Belongs to the GSP E family.