53952:A0127 RS02060
gene id: 53952:A0127_RS02060
uniprot id: A0A142CTD9
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

53952:A0127 RS00890
gene id: 53952:A0127_RS00890
uniprot id: A0A142CST0
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

53952:A0127 RS09860
gene id: 53952:A0127_RS09860
uniprot id: A0A142CXE0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

53952:A0127 RS07555
gene id: 53952:A0127_RS07555
uniprot id: A0A142CW81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS00700
gene id: 53952:A0127_RS00700
uniprot id: A0A142CSP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

53952:A0127 RS03175
gene id: 53952:A0127_RS03175
uniprot id: A0A142CTY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

53952:A0127 RS01240
gene id: 53952:A0127_RS01240
uniprot id: A0A142CSY9
names: Similarity
messages: Belongs to the UPF0235 family.

53952:A0127 RS00350
gene id: 53952:A0127_RS00350
uniprot id: A0A142CSH4
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS00065
gene id: 53952:A0127_RS00065
uniprot id: A0A142CSC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

53952:A0127 RS10075
gene id: 53952:A0127_RS10075
uniprot id: A0A142CXS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

53952:A0127 RS02995
gene id: 53952:A0127_RS02995
uniprot id: A0A142CTV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

53952:A0127 RS03440
gene id: 53952:A0127_RS03440
uniprot id: A0A142CU38
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

53952:A0127 RS04445
gene id: 53952:A0127_RS04445
uniprot id: A0A142CUL9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

53952:A0127 RS07220
gene id: 53952:A0127_RS07220
uniprot id: A0A142CW22
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

53952:A0127 RS06655
gene id: 53952:A0127_RS06655
uniprot id: A0A142CVS1
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS06180
gene id: 53952:A0127_RS06180
uniprot id: A0A142CVI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

53952:A0127 RS00525
gene id: 53952:A0127_RS00525
uniprot id: A0A142CSK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

53952:A0127 RS04855
gene id: 53952:A0127_RS04855
uniprot id: A0A142CXL6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

53952:A0127 RS09730
gene id: 53952:A0127_RS09730
uniprot id: A0A142CXB5
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

53952:A0127 RS04030
gene id: 53952:A0127_RS04030
uniprot id: A0A142CUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

53952:A0127 RS04235
gene id: 53952:A0127_RS04235
uniprot id: A0A142CUI2
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

53952:A0127 RS04985
gene id: 53952:A0127_RS04985
uniprot id: A0A142CUW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

53952:A0127 RS07600
gene id: 53952:A0127_RS07600
uniprot id: A0A142CW90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

53952:A0127 RS03735
gene id: 53952:A0127_RS03735
uniprot id: A0A142CU92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

53952:A0127 RS06365
gene id: 53952:A0127_RS06365
uniprot id: A0A142CVL9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

53952:A0127 RS09900
gene id: 53952:A0127_RS09900
uniprot id: A0A142CXE8
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS00800
gene id: 53952:A0127_RS00800
uniprot id: A0A142CSR2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

53952:A0127 RS04575
gene id: 53952:A0127_RS04575
uniprot id: A0A142CUP2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

53952:A0127 RS09695
gene id: 53952:A0127_RS09695
uniprot id: A0A142CXA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
messages: Cytoplasm

53952:A0127 RS09705
gene id: 53952:A0127_RS09705
uniprot id: A0A142CXB0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

53952:A0127 RS09440
gene id: 53952:A0127_RS09440
uniprot id: A0A142CX62
names: Similarity
messages: Belongs to the HypD family.

53952:A0127 RS04100
gene id: 53952:A0127_RS04100
uniprot id: A0A142CUF9
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05775
gene id: 53952:A0127_RS05775
uniprot id: A0A142CVA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

53952:A0127 RS04910
gene id: 53952:A0127_RS04910
uniprot id: A0A142CUU8
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

53952:A0127 RS02985
gene id: 53952:A0127_RS02985
uniprot id: A0A142CTV0
names: Similarity
messages: Belongs to the GARS family.

53952:A0127 RS07325
gene id: 53952:A0127_RS07325
uniprot id: A0A142CW38
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

53952:A0127 RS08680
gene id: 53952:A0127_RS08680
uniprot id: A0A142CWS9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS04365
gene id: 53952:A0127_RS04365
uniprot id: A0A142CUK7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

53952:A0127 RS09515
gene id: 53952:A0127_RS09515
uniprot id: A0A142CX77
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

53952:A0127 RS05420
gene id: 53952:A0127_RS05420
uniprot id: A0A142CV43
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

53952:A0127 RS05040
gene id: 53952:A0127_RS05040
uniprot id: A0A142CUX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

53952:A0127 RS07510
gene id: 53952:A0127_RS07510
uniprot id: A0A142CW72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS08055
gene id: 53952:A0127_RS08055
uniprot id: A0A142CWG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

53952:A0127 RS07490
gene id: 53952:A0127_RS07490
uniprot id: A0A142CW69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

53952:A0127 RS05085
gene id: 53952:A0127_RS05085
uniprot id: A0A142CUY0
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS07245
gene id: 53952:A0127_RS07245
uniprot id: A0A142CW27
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

53952:A0127 RS07040
gene id: 53952:A0127_RS07040
uniprot id: A0A142CVY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

53952:A0127 RS07215
gene id: 53952:A0127_RS07215
uniprot id: A0A142CW21
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

53952:A0127 RS09060
gene id: 53952:A0127_RS09060
uniprot id: A0A142CWZ7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

53952:A0127 RS00290
gene id: 53952:A0127_RS00290
uniprot id: A0A142CSG2
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS00115
gene id: 53952:A0127_RS00115
uniprot id: A0A142CSC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

53952:A0127 RS02605
gene id: 53952:A0127_RS02605
uniprot id: A0A142CTN5
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS08705
gene id: 53952:A0127_RS08705
uniprot id: A0A142CWT2
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01070
gene id: 53952:A0127_RS01070
uniprot id: A0A142CSW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

53952:A0127 RS00965
gene id: 53952:A0127_RS00965
uniprot id: A0A142CSU3
names: Similarity
messages: Belongs to the glutaredoxin family.

53952:A0127 RS01935
gene id: 53952:A0127_RS01935
uniprot id: A0A142CTB5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

53952:A0127 RS08120
gene id: 53952:A0127_RS08120
uniprot id: A0A142CWH9
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS06765
gene id: 53952:A0127_RS06765
uniprot id: A0A142CVT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

53952:A0127 RS03225
gene id: 53952:A0127_RS03225
uniprot id: A0A142CTZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

53952:A0127 RS03365
gene id: 53952:A0127_RS03365
uniprot id: A0A142CU23
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

53952:A0127 RS07345
gene id: 53952:A0127_RS07345
uniprot id: A0A142CW42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

53952:A0127 RS09575
gene id: 53952:A0127_RS09575
uniprot id: A0A142CX87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

53952:A0127 RS02045
gene id: 53952:A0127_RS02045
uniprot id: A0A142CTD6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

53952:A0127 RS09910
gene id: 53952:A0127_RS09910
uniprot id: A0A142CXF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

53952:A0127 RS03070
gene id: 53952:A0127_RS03070
uniprot id: A0A142CTW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

53952:A0127 RS07165
gene id: 53952:A0127_RS07165
uniprot id: A0A142CW11
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

53952:A0127 RS09400
gene id: 53952:A0127_RS09400
uniprot id: A0A142CX57
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS05250
gene id: 53952:A0127_RS05250
uniprot id: A0A142CV12
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

53952:A0127 RS07870
gene id: 53952:A0127_RS07870
uniprot id: A0A142CWD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

53952:A0127 RS03580
gene id: 53952:A0127_RS03580
uniprot id: A0A142CU64
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

53952:A0127 RS09630
gene id: 53952:A0127_RS09630
uniprot id: A0A142CX96
names: Similarity
messages: Belongs to the AOR/FOR family.

53952:A0127 RS00550
gene id: 53952:A0127_RS00550
uniprot id: A0A142CSL2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

53952:A0127 RS02690
gene id: 53952:A0127_RS02690
uniprot id: A0A142CTP9
names: Similarity
messages: Belongs to the UPF0248 family.

53952:A0127 RS00500
gene id: 53952:A0127_RS00500
uniprot id: A0A142CSK2
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS09475
gene id: 53952:A0127_RS09475
uniprot id: A0A142CX69
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01400
gene id: 53952:A0127_RS01400
uniprot id: A0A142CT17
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

53952:A0127 RS08700
gene id: 53952:A0127_RS08700
uniprot id: A0A142CWT1
names: Similarity
messages: Belongs to the UPF0107 family.

53952:A0127 RS00205
gene id: 53952:A0127_RS00205
uniprot id: A0A142CSE7
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

53952:A0127 RS07985
gene id: 53952:A0127_RS07985
uniprot id: A0A142CWF6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

53952:A0127 RS03355
gene id: 53952:A0127_RS03355
uniprot id: A0A142CU21
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

53952:A0127 RS08440
gene id: 53952:A0127_RS08440
uniprot id: A0A142CWN3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

53952:A0127 RS08205
gene id: 53952:A0127_RS08205
uniprot id: A0A142CWJ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS02460
gene id: 53952:A0127_RS02460
uniprot id: A0A142CTK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS04460
gene id: 53952:A0127_RS04460
uniprot id: A0A142CUM2
names: Similarity
messages: Belongs to the peptidase U62 family.

53952:A0127 RS06300
gene id: 53952:A0127_RS06300
uniprot id: A0A142CVK6
names: Similarity
messages: Belongs to the HsdR family.

53952:A0127 RS00785
gene id: 53952:A0127_RS00785
uniprot id: A0A142CSQ9
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

53952:A0127 RS01270
gene id: 53952:A0127_RS01270
uniprot id: A0A142CSZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

53952:A0127 RS09580
gene id: 53952:A0127_RS09580
uniprot id: A0A142CX88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS03590
gene id: 53952:A0127_RS03590
uniprot id: A0A142CU66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

53952:A0127 RS06070
gene id: 53952:A0127_RS06070
uniprot id: A0A142CXM6
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01870
gene id: 53952:A0127_RS01870
uniprot id: A0A142CTA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

53952:A0127 RS05005
gene id: 53952:A0127_RS05005
uniprot id: A0A142CUW5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

53952:A0127 RS02565
gene id: 53952:A0127_RS02565
uniprot id: A0A142CTM7
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

53952:A0127 RS01585
gene id: 53952:A0127_RS01585
uniprot id: A0A142CT50
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

53952:A0127 RS06560
gene id: 53952:A0127_RS06560
uniprot id: A0A142CVQ4
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS09925
gene id: 53952:A0127_RS09925
uniprot id: A0A142CXF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

53952:A0127 RS08625
gene id: 53952:A0127_RS08625
uniprot id: A0A142CWR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

53952:A0127 RS08495
gene id: 53952:A0127_RS08495
uniprot id: A0A142CWP3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

53952:A0127 RS08655
gene id: 53952:A0127_RS08655
uniprot id: A0A142CWS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

53952:A0127 RS09480
gene id: 53952:A0127_RS09480
uniprot id: A0A142CX70
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05575
gene id: 53952:A0127_RS05575
uniprot id: A0A142CV73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

53952:A0127 RS09795
gene id: 53952:A0127_RS09795
uniprot id: A0A142CXC7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

53952:A0127 RS09320
gene id: 53952:A0127_RS09320
uniprot id: A0A142CX42
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

53952:A0127 RS07920
gene id: 53952:A0127_RS07920
uniprot id: A0A142CWE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

53952:A0127 RS07595
gene id: 53952:A0127_RS07595
uniprot id: A0A142CW89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

53952:A0127 RS02165
gene id: 53952:A0127_RS02165
uniprot id: A0A142CTF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

53952:A0127 RS05580
gene id: 53952:A0127_RS05580
uniprot id: A0A142CV74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

53952:A0127 RS08485
gene id: 53952:A0127_RS08485
uniprot id: A0A142CWP1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

53952:A0127 RS01100
gene id: 53952:A0127_RS01100
uniprot id: A0A142CSW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

53952:A0127 RS03200
gene id: 53952:A0127_RS03200
uniprot id: A0A142CTZ2
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01955
gene id: 53952:A0127_RS01955
uniprot id: A0A142CTB9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

53952:A0127 RS05945
gene id: 53952:A0127_RS05945
uniprot id: A0A142CVE1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

53952:A0127 RS03015
gene id: 53952:A0127_RS03015
uniprot id: A0A142CTV6
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

53952:A0127 RS07270
gene id: 53952:A0127_RS07270
uniprot id: A0A142CW32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

53952:A0127 RS07590
gene id: 53952:A0127_RS07590
uniprot id: A0A142CW88
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

53952:A0127 RS06345
gene id: 53952:A0127_RS06345
uniprot id: A0A142CVL5
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS06775
gene id: 53952:A0127_RS06775
uniprot id: A0A142CVU1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

53952:A0127 RS06760
gene id: 53952:A0127_RS06760
uniprot id: A0A142CVT8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

53952:A0127 RS04970
gene id: 53952:A0127_RS04970
uniprot id: A0A142CUV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

53952:A0127 RS06580
gene id: 53952:A0127_RS06580
uniprot id: A0A142CVQ8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

53952:A0127 RS02130
gene id: 53952:A0127_RS02130
uniprot id: A0A142CXJ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS07605
gene id: 53952:A0127_RS07605
uniprot id: A0A142CW91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

53952:A0127 RS04830
gene id: 53952:A0127_RS04830
uniprot id: A0A142CXL5
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

53952:A0127 RS02055
gene id: 53952:A0127_RS02055
uniprot id: A0A142CTD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

53952:A0127 RS04990
gene id: 53952:A0127_RS04990
uniprot id: A0A142CUW2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

53952:A0127 RS00295
gene id: 53952:A0127_RS00295
uniprot id: A0A142CSG3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

53952:A0127 RS08105
gene id: 53952:A0127_RS08105
uniprot id: A0A142CWH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

53952:A0127 RS05410
gene id: 53952:A0127_RS05410
uniprot id: A0A142CV41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

53952:A0127 RS06435
gene id: 53952:A0127_RS06435
uniprot id: A0A142CVN2
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

53952:A0127 RS09980
gene id: 53952:A0127_RS09980
uniprot id: A0A142CXG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

53952:A0127 RS09230
gene id: 53952:A0127_RS09230
uniprot id: A0A142CX27
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

53952:A0127 RS08270
gene id: 53952:A0127_RS08270
uniprot id: A0A142CWK1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

53952:A0127 RS07240
gene id: 53952:A0127_RS07240
uniprot id: A0A142CW26
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

53952:A0127 RS09745
gene id: 53952:A0127_RS09745
uniprot id: A0A142CXB8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

53952:A0127 RS09990
gene id: 53952:A0127_RS09990
uniprot id: A0A142CXG4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

53952:A0127 RS05235
gene id: 53952:A0127_RS05235
uniprot id: A0A142CV09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

53952:A0127 RS01045
gene id: 53952:A0127_RS01045
uniprot id: A0A142CSV7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

53952:A0127 RS09815
gene id: 53952:A0127_RS09815
uniprot id: A0A142CXD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

53952:A0127 RS08735
gene id: 53952:A0127_RS08735
uniprot id: A0A142CWT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

53952:A0127 RS08975
gene id: 53952:A0127_RS08975
uniprot id: A0A142CWY1
names: Similarity
messages: Belongs to the UPF0212 family.

53952:A0127 RS05105
gene id: 53952:A0127_RS05105
uniprot id: A0A142CUY4
names: Similarity
messages: Belongs to the CutA family.

53952:A0127 RS08835
gene id: 53952:A0127_RS08835
uniprot id: A0A142CWV5
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS07230
gene id: 53952:A0127_RS07230
uniprot id: A0A142CW24
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

53952:A0127 RS10185
gene id: 53952:A0127_RS10185
uniprot id: A0A142CXU1
names: Similarity
messages: Belongs to the AAA ATPase family.

53952:A0127 RS09605
gene id: 53952:A0127_RS09605
uniprot id: A0A142CX92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

53952:A0127 RS00185
gene id: 53952:A0127_RS00185
uniprot id: A0A142CSE3
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01905
gene id: 53952:A0127_RS01905
uniprot id: A0A142CTA9
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

53952:A0127 RS02925
gene id: 53952:A0127_RS02925
uniprot id: A0A142CTT8
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

53952:A0127 RS09125
gene id: 53952:A0127_RS09125
uniprot id: A0A142CX07
names: Similarity
messages: Belongs to the peptidase S49 family.

53952:A0127 RS07585
gene id: 53952:A0127_RS07585
uniprot id: A0A142CW87
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

53952:A0127 RS09720
gene id: 53952:A0127_RS09720
uniprot id: A0A142CXB3
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01780
gene id: 53952:A0127_RS01780
uniprot id: A0A142CT86
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

53952:A0127 RS03875
gene id: 53952:A0127_RS03875
uniprot id: A0A142CUB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

53952:A0127 RS09415
gene id: 53952:A0127_RS09415
uniprot id: A0A142CX59
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS08825
gene id: 53952:A0127_RS08825
uniprot id: A0A142CWV4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS06840
gene id: 53952:A0127_RS06840
uniprot id: A0A142CVV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

53952:A0127 RS00875
gene id: 53952:A0127_RS00875
uniprot id: A0A142CSS7
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS04875
gene id: 53952:A0127_RS04875
uniprot id: A0A142CUU3
names: Subunit
messages: Homotetramer.

53952:A0127 RS07485
gene id: 53952:A0127_RS07485
uniprot id: A0A142CW68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

53952:A0127 RS03105
gene id: 53952:A0127_RS03105
uniprot id: A0A142CTX4
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

53952:A0127 RS03830
gene id: 53952:A0127_RS03830
uniprot id: A0A142CUB0
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS04920
gene id: 53952:A0127_RS04920
uniprot id: A0A142CUV0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

53952:A0127 RS08025
gene id: 53952:A0127_RS08025
uniprot id: A0A142CWG1
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

53952:A0127 RS09030
gene id: 53952:A0127_RS09030
uniprot id: A0A142CWZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

53952:A0127 RS07695
gene id: 53952:A0127_RS07695
uniprot id: A0A142CWA7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

53952:A0127 RS01940
gene id: 53952:A0127_RS01940
uniprot id: A0A142CTB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

53952:A0127 RS01535
gene id: 53952:A0127_RS01535
uniprot id: A0A142CT42
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

53952:A0127 RS07690
gene id: 53952:A0127_RS07690
uniprot id: A0A142CWA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

53952:A0127 RS01150
gene id: 53952:A0127_RS01150
uniprot id: A0A142CSX5
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS03775
gene id: 53952:A0127_RS03775
uniprot id: A0A142CUA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

53952:A0127 RS01910
gene id: 53952:A0127_RS01910
uniprot id: A0A142CTB0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

53952:A0127 RS07860
gene id: 53952:A0127_RS07860
uniprot id: A0A142CWD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS01265
gene id: 53952:A0127_RS01265
uniprot id: A0A142CSZ4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

53952:A0127 RS03035
gene id: 53952:A0127_RS03035
uniprot id: A0A142CTW0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

53952:A0127 RS04285
gene id: 53952:A0127_RS04285
uniprot id: A0A142CXK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

53952:A0127 RS06615
gene id: 53952:A0127_RS06615
uniprot id: A0A142CVR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

53952:A0127 RS02620
gene id: 53952:A0127_RS02620
uniprot id: A0A142CTN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

53952:A0127 RS07050
gene id: 53952:A0127_RS07050
uniprot id: A0A142CXN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

53952:A0127 RS01925
gene id: 53952:A0127_RS01925
uniprot id: A0A142CTB3
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

53952:A0127 RS03480
gene id: 53952:A0127_RS03480
uniprot id: A0A142CU46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS09850
gene id: 53952:A0127_RS09850
uniprot id: A0A142CXD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS01095
gene id: 53952:A0127_RS01095
uniprot id: A0A142CSW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

53952:A0127 RS02510
gene id: 53952:A0127_RS02510
uniprot id: A0A142CTL7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

53952:A0127 RS08100
gene id: 53952:A0127_RS08100
uniprot id: A0A142CWH5
names: Similarity
messages: Belongs to the UPF0292 family.

53952:A0127 RS09535
gene id: 53952:A0127_RS09535
uniprot id: A0A142CX81
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS09825
gene id: 53952:A0127_RS09825
uniprot id: A0A142CXD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

53952:A0127 RS07225
gene id: 53952:A0127_RS07225
uniprot id: A0A142CW23
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

53952:A0127 RS02640
gene id: 53952:A0127_RS02640
uniprot id: A0A142CTP1
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

53952:A0127 RS04815
gene id: 53952:A0127_RS04815
uniprot id: A0A142CUT4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

53952:A0127 RS01605
gene id: 53952:A0127_RS01605
uniprot id: A0A142CT54
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

53952:A0127 RS03170
gene id: 53952:A0127_RS03170
uniprot id: A0A142CTY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

53952:A0127 RS07250
gene id: 53952:A0127_RS07250
uniprot id: A0A142CW28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

53952:A0127 RS05295
gene id: 53952:A0127_RS05295
uniprot id: A0A142CV19
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS09165
gene id: 53952:A0127_RS09165
uniprot id: A0A142CX15
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

53952:A0127 RS00815
gene id: 53952:A0127_RS00815
uniprot id: A0A142CSR5
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS02955
gene id: 53952:A0127_RS02955
uniprot id: A0A142CTU4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

53952:A0127 RS08815
gene id: 53952:A0127_RS08815
uniprot id: A0A142CWV2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS04650
gene id: 53952:A0127_RS04650
uniprot id: A0A142CUQ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

53952:A0127 RS00220
gene id: 53952:A0127_RS00220
uniprot id: A0A142CSE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

53952:A0127 RS03925
gene id: 53952:A0127_RS03925
uniprot id: A0A142CUC9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

53952:A0127 RS02960
gene id: 53952:A0127_RS02960
uniprot id: A0A142CTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

53952:A0127 RS06155
gene id: 53952:A0127_RS06155
uniprot id: A0A142CXM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

53952:A0127 RS01980
gene id: 53952:A0127_RS01980
uniprot id: A0A142CTC4
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

53952:A0127 RS02360
gene id: 53952:A0127_RS02360
uniprot id: A0A142CTJ1
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

53952:A0127 RS05990
gene id: 53952:A0127_RS05990
uniprot id: A0A142CVE8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

53952:A0127 RS06395
gene id: 53952:A0127_RS06395
uniprot id: A0A142CVM5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

53952:A0127 RS08365
gene id: 53952:A0127_RS08365
uniprot id: A0A142CWL9
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS02505
gene id: 53952:A0127_RS02505
uniprot id: A0A142CTL6
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

53952:A0127 RS09235
gene id: 53952:A0127_RS09235
uniprot id: A0A142CX28
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

53952:A0127 RS08050
gene id: 53952:A0127_RS08050
uniprot id: A0A142CWG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

53952:A0127 RS01775
gene id: 53952:A0127_RS01775
uniprot id: A0A142CT85
names: Similarity
messages: Belongs to the pyruvate kinase family.

53952:A0127 RS07835
gene id: 53952:A0127_RS07835
uniprot id: A0A142CWC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

53952:A0127 RS07505
gene id: 53952:A0127_RS07505
uniprot id: A0A142CW71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

53952:A0127 RS08125
gene id: 53952:A0127_RS08125
uniprot id: A0A142CWI0
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

53952:A0127 RS09845
gene id: 53952:A0127_RS09845
uniprot id: A0A142CXD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

53952:A0127 RS05870
gene id: 53952:A0127_RS05870
uniprot id: A0A142CVC6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

53952:A0127 RS03840
gene id: 53952:A0127_RS03840
uniprot id: A0A142CUB2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

53952:A0127 RS09570
gene id: 53952:A0127_RS09570
uniprot id: A0A142CX86
names: Similarity
messages: Belongs to the GbsR family.

53952:A0127 RS05020
gene id: 53952:A0127_RS05020
uniprot id: A0A142CUW8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

53952:A0127 RS07710
gene id: 53952:A0127_RS07710
uniprot id: A0A142CWA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

53952:A0127 RS01220
gene id: 53952:A0127_RS01220
uniprot id: A0A142CSY6
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01950
gene id: 53952:A0127_RS01950
uniprot id: A0A142CTB8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

53952:A0127 RS05485
gene id: 53952:A0127_RS05485
uniprot id: A0A142CV56
names: Similarity
messages: Belongs to the MoaD family.

53952:A0127 RS07365
gene id: 53952:A0127_RS07365
uniprot id: A0A142CW46
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

53952:A0127 RS10035
gene id: 53952:A0127_RS10035
uniprot id: A0A142CXH3
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

53952:A0127 RS10030
gene id: 53952:A0127_RS10030
uniprot id: A0A142CXH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

53952:A0127 RS00430
gene id: 53952:A0127_RS00430
uniprot id: A0A142CSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

53952:A0127 RS09040
gene id: 53952:A0127_RS09040
uniprot id: A0A142CWZ3
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

53952:A0127 RS00730
gene id: 53952:A0127_RS00730
uniprot id: A0A142CSP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

53952:A0127 RS03510
gene id: 53952:A0127_RS03510
uniprot id: A0A142CU52
names: Similarity
messages: Belongs to the UPF0201 family.

53952:A0127 RS10290
gene id: 53952:A0127_RS10290
uniprot id: A0A142CXV7
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

53952:A0127 RS06985
gene id: 53952:A0127_RS06985
uniprot id: A0A142CVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

53952:A0127 RS02330
gene id: 53952:A0127_RS02330
uniprot id: A0A142CTI6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

53952:A0127 RS04780
gene id: 53952:A0127_RS04780
uniprot id: A0A142CUS7
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS00405
gene id: 53952:A0127_RS00405
uniprot id: A0A142CSI5
names: Similarity
messages: Belongs to the SNAP family.

53952:A0127 RS09310
gene id: 53952:A0127_RS09310
uniprot id: A0A142CX40
names: Cofactor
messages: Binds 1 zinc ion per subunit.

53952:A0127 RS08090
gene id: 53952:A0127_RS08090
uniprot id: A0A142CWH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

53952:A0127 RS08170
gene id: 53952:A0127_RS08170
uniprot id: A0A142CXQ2
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

53952:A0127 RS03550
gene id: 53952:A0127_RS03550
uniprot id: A0A142CU59
names: Similarity
messages: Belongs to the AOR/FOR family.

53952:A0127 RS03065
gene id: 53952:A0127_RS03065
uniprot id: A0A142CTW6
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

53952:A0127 RS06355
gene id: 53952:A0127_RS06355
uniprot id: A0A142CVL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

53952:A0127 RS00690
gene id: 53952:A0127_RS00690
uniprot id: A0A142CSP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

53952:A0127 RS02295
gene id: 53952:A0127_RS02295
uniprot id: A0A142CTI1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

53952:A0127 RS04265
gene id: 53952:A0127_RS04265
uniprot id: A0A142CUI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

53952:A0127 RS08745
gene id: 53952:A0127_RS08745
uniprot id: A0A142CWT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

53952:A0127 RS02325
gene id: 53952:A0127_RS02325
uniprot id: A0A142CTI5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

53952:A0127 RS00520
gene id: 53952:A0127_RS00520
uniprot id: A0A142CSK6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

53952:A0127 RS07945
gene id: 53952:A0127_RS07945
uniprot id: A0A142CWE8
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

53952:A0127 RS02965
gene id: 53952:A0127_RS02965
uniprot id: A0A142CTU6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS00575
gene id: 53952:A0127_RS00575
uniprot id: A0A142CSL7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

53952:A0127 RS08330
gene id: 53952:A0127_RS08330
uniprot id: A0A142CWL2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

53952:A0127 RS06335
gene id: 53952:A0127_RS06335
uniprot id: A0A142CVL3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

53952:A0127 RS02815
gene id: 53952:A0127_RS02815
uniprot id: A0A142CTS0
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

53952:A0127 RS08980
gene id: 53952:A0127_RS08980
uniprot id: A0A142CWY2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS03695
gene id: 53952:A0127_RS03695
uniprot id: A0A142CU86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

53952:A0127 RS03685
gene id: 53952:A0127_RS03685
uniprot id: A0A142CU85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

53952:A0127 RS06220
gene id: 53952:A0127_RS06220
uniprot id: A0A142CVJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

53952:A0127 RS02150
gene id: 53952:A0127_RS02150
uniprot id: A0A142CTF5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS08060
gene id: 53952:A0127_RS08060
uniprot id: A0A142CWG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

53952:A0127 RS07925
gene id: 53952:A0127_RS07925
uniprot id: A0A142CWE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

53952:A0127 RS03505
gene id: 53952:A0127_RS03505
uniprot id: A0A142CU51
names: Similarity
messages: Belongs to the UPF0200 family.

53952:A0127 RS00175
gene id: 53952:A0127_RS00175
uniprot id: A0A142CSE1
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

53952:A0127 RS06025
gene id: 53952:A0127_RS06025
uniprot id: A0A142CVF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

53952:A0127 RS02720
gene id: 53952:A0127_RS02720
uniprot id: A0A142CTQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS01345
gene id: 53952:A0127_RS01345
uniprot id: A0A142CT08
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

53952:A0127 RS02250
gene id: 53952:A0127_RS02250
uniprot id: A0A142CTH2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

53952:A0127 RS07280
gene id: 53952:A0127_RS07280
uniprot id: A0A142CXN8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

53952:A0127 RS07940
gene id: 53952:A0127_RS07940
uniprot id: A0A142CWE7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

53952:A0127 RS01165
gene id: 53952:A0127_RS01165
uniprot id: A0A142CSX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

53952:A0127 RS09835
gene id: 53952:A0127_RS09835
uniprot id: A0A142CXD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

53952:A0127 RS09240
gene id: 53952:A0127_RS09240
uniprot id: A0A142CX29
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05015
gene id: 53952:A0127_RS05015
uniprot id: A0A142CUW7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

53952:A0127 RS01850
gene id: 53952:A0127_RS01850
uniprot id: A0A142CT99
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS08535
gene id: 53952:A0127_RS08535
uniprot id: A0A142CWQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS04645
gene id: 53952:A0127_RS04645
uniprot id: A0A142CUQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

53952:A0127 RS09185
gene id: 53952:A0127_RS09185
uniprot id: A0A142CXR5
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS00455
gene id: 53952:A0127_RS00455
uniprot id: A0A142CSJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

53952:A0127 RS00255
gene id: 53952:A0127_RS00255
uniprot id: A0A142CSF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

53952:A0127 RS07570
gene id: 53952:A0127_RS07570
uniprot id: A0A142CW84
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

53952:A0127 RS03255
gene id: 53952:A0127_RS03255
uniprot id: A0A142CU02
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

53952:A0127 RS00680
gene id: 53952:A0127_RS00680
uniprot id: A0A142CSN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS02940
gene id: 53952:A0127_RS02940
uniprot id: A0A142CTU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

53952:A0127 RS07845
gene id: 53952:A0127_RS07845
uniprot id: A0A142CWC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

53952:A0127 RS09010
gene id: 53952:A0127_RS09010
uniprot id: A0A142CWY8
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

53952:A0127 RS04665
gene id: 53952:A0127_RS04665
uniprot id: A0A142CUQ8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

53952:A0127 RS06340
gene id: 53952:A0127_RS06340
uniprot id: A0A142CVL4
names: Similarity
messages: Belongs to the UPF0146 family.

53952:A0127 RS01350
gene id: 53952:A0127_RS01350
uniprot id: A0A142CT09
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS04745
gene id: 53952:A0127_RS04745
uniprot id: A0A142CUS1
names: Similarity
messages: Belongs to the carbamate kinase family.

53952:A0127 RS08850
gene id: 53952:A0127_RS08850
uniprot id: A0A142CWV8
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS09525
gene id: 53952:A0127_RS09525
uniprot id: A0A142CX79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

53952:A0127 RS07530
gene id: 53952:A0127_RS07530
uniprot id: A0A142CW76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS00310
gene id: 53952:A0127_RS00310
uniprot id: A0A142CSG6
names: Similarity
messages: Belongs to the peptidase M24B family.

53952:A0127 RS07125
gene id: 53952:A0127_RS07125
uniprot id: A0A142CW03
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

53952:A0127 RS08545
gene id: 53952:A0127_RS08545
uniprot id: A0A142CWQ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

53952:A0127 RS09700
gene id: 53952:A0127_RS09700
uniprot id: A0A142CXA9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

53952:A0127 RS10065
gene id: 53952:A0127_RS10065
uniprot id: A0A142CXH7
names: Similarity
messages: Belongs to the HypE family.

53952:A0127 RS03985
gene id: 53952:A0127_RS03985
uniprot id: A0A142CUE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

53952:A0127 RS06225
gene id: 53952:A0127_RS06225
uniprot id: A0A142CVJ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

53952:A0127 RS01745
gene id: 53952:A0127_RS01745
uniprot id: A0A142CT79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

53952:A0127 RS00920
gene id: 53952:A0127_RS00920
uniprot id: A0A142CST6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

53952:A0127 RS02525
gene id: 53952:A0127_RS02525
uniprot id: A0A142CXJ9
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS03060
gene id: 53952:A0127_RS03060
uniprot id: A0A142CTW5
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

53952:A0127 RS06380
gene id: 53952:A0127_RS06380
uniprot id: A0A142CVM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

53952:A0127 RS02575
gene id: 53952:A0127_RS02575
uniprot id: A0A142CTM9
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS03800
gene id: 53952:A0127_RS03800
uniprot id: A0A142CUA5
names: Similarity
messages: Belongs to the UPF0047 family.

53952:A0127 RS00385
gene id: 53952:A0127_RS00385
uniprot id: A0A142CSI1
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

53952:A0127 RS01785
gene id: 53952:A0127_RS01785
uniprot id: A0A142CT87
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS07535
gene id: 53952:A0127_RS07535
uniprot id: A0A142CW77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

53952:A0127 RS07875
gene id: 53952:A0127_RS07875
uniprot id: A0A142CWD4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

53952:A0127 RS07065
gene id: 53952:A0127_RS07065
uniprot id: A0A142CVZ2
names: Similarity
messages: Belongs to the ZPR1 family.

53952:A0127 RS09305
gene id: 53952:A0127_RS09305
uniprot id: A0A142CX39
names: Similarity
messages: Belongs to the UPF0127 family.

53952:A0127 RS05615
gene id: 53952:A0127_RS05615
uniprot id: A0A142CV78
names: Similarity
messages: Belongs to the UPF0310 family.

53952:A0127 RS08240
gene id: 53952:A0127_RS08240
uniprot id: A0A142CWJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

53952:A0127 RS00720
gene id: 53952:A0127_RS00720
uniprot id: A0A142CSP6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS07675
gene id: 53952:A0127_RS07675
uniprot id: A0A142CWA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

53952:A0127 RS00260
gene id: 53952:A0127_RS00260
uniprot id: A0A142CSF7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

53952:A0127 RS07970
gene id: 53952:A0127_RS07970
uniprot id: A0A142CWF3
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS02220
gene id: 53952:A0127_RS02220
uniprot id: A0A142CTG7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

53952:A0127 RS07910
gene id: 53952:A0127_RS07910
uniprot id: A0A142CWE1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

53952:A0127 RS00100
gene id: 53952:A0127_RS00100
uniprot id: A0A142CSC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

53952:A0127 RS03940
gene id: 53952:A0127_RS03940
uniprot id: A0A142CXK6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

53952:A0127 RS08955
gene id: 53952:A0127_RS08955
uniprot id: A0A142CWX7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS03565
gene id: 53952:A0127_RS03565
uniprot id: A0A142CU61
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

53952:A0127 RS04295
gene id: 53952:A0127_RS04295
uniprot id: A0A142CUJ3
names: Similarity
messages: Belongs to the HerA family.

53952:A0127 RS01245
gene id: 53952:A0127_RS01245
uniprot id: A0A142CSZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

53952:A0127 RS01310
gene id: 53952:A0127_RS01310
uniprot id: A0A142CT02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

53952:A0127 RS07715
gene id: 53952:A0127_RS07715
uniprot id: A0A142CWB0
names: Similarity
messages: Belongs to the enolase family.

53952:A0127 RS04160
gene id: 53952:A0127_RS04160
uniprot id: A0A142CUH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

53952:A0127 RS09210
gene id: 53952:A0127_RS09210
uniprot id: A0A142CX23
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

53952:A0127 RS09820
gene id: 53952:A0127_RS09820
uniprot id: A0A142CXD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

53952:A0127 RS02000
gene id: 53952:A0127_RS02000
uniprot id: A0A142CTC8
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

53952:A0127 RS03085
gene id: 53952:A0127_RS03085
uniprot id: A0A142CTX0
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

53952:A0127 RS08035
gene id: 53952:A0127_RS08035
uniprot id: A0A142CWG3
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05120
gene id: 53952:A0127_RS05120
uniprot id: A0A142CUY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

53952:A0127 RS05230
gene id: 53952:A0127_RS05230
uniprot id: A0A142CV08
names: Similarity
messages: Belongs to the UPF0111 family.

53952:A0127 RS01540
gene id: 53952:A0127_RS01540
uniprot id: A0A142CT43
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01740
gene id: 53952:A0127_RS01740
uniprot id: A0A142CT78
names: Similarity
messages: Belongs to the UPF0166 family.

53952:A0127 RS00625
gene id: 53952:A0127_RS00625
uniprot id: A0A142CSM7
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

53952:A0127 RS02105
gene id: 53952:A0127_RS02105
uniprot id: A0A142CTE7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

53952:A0127 RS07670
gene id: 53952:A0127_RS07670
uniprot id: A0A142CWA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS08115
gene id: 53952:A0127_RS08115
uniprot id: A0A142CWH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

53952:A0127 RS02710
gene id: 53952:A0127_RS02710
uniprot id: A0A142CTQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

53952:A0127 RS02160
gene id: 53952:A0127_RS02160
uniprot id: A0A142CTF7
names: Function
messages: Probably involved in the biogenesis of the ribosome.

53952:A0127 RS07575
gene id: 53952:A0127_RS07575
uniprot id: A0A142CW85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

53952:A0127 RS01555
gene id: 53952:A0127_RS01555
uniprot id: A0A142CT45
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

53952:A0127 RS05100
gene id: 53952:A0127_RS05100
uniprot id: A0A142CUY3
names: Similarity
messages: Belongs to the acylphosphatase family.

53952:A0127 RS10310
gene id: 53952:A0127_RS10310
uniprot id: A0A142CXW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

53952:A0127 RS04085
gene id: 53952:A0127_RS04085
uniprot id: A0A142CUF6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

53952:A0127 RS03515
gene id: 53952:A0127_RS03515
uniprot id: A0A142CU53
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05805
gene id: 53952:A0127_RS05805
uniprot id: A0A142CVB3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS05565
gene id: 53952:A0127_RS05565
uniprot id: A0A142CV71
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

53952:A0127 RS06860
gene id: 53952:A0127_RS06860
uniprot id: A0A142CVV4
names: Similarity
messages: Belongs to the UPF0282 family.

53952:A0127 RS01900
gene id: 53952:A0127_RS01900
uniprot id: A0A142CTA8
names: Similarity
messages: Belongs to the UPF0251 family.

53952:A0127 RS09005
gene id: 53952:A0127_RS09005
uniprot id: A0A142CWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

53952:A0127 RS06940
gene id: 53952:A0127_RS06940
uniprot id: A0A142CVX0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

53952:A0127 RS04880
gene id: 53952:A0127_RS04880
uniprot id: A0A142CUU4
names: Similarity
messages: Belongs to the UPF0147 family.

53952:A0127 RS00640
gene id: 53952:A0127_RS00640
uniprot id: A0A142CSN0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

53952:A0127 RS08880
gene id: 53952:A0127_RS08880
uniprot id: A0A142CWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

53952:A0127 RS05450
gene id: 53952:A0127_RS05450
uniprot id: A0A142CV49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

53952:A0127 RS01420
gene id: 53952:A0127_RS01420
uniprot id: A0A142CT21
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS04210
gene id: 53952:A0127_RS04210
uniprot id: A0A142CUH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

53952:A0127 RS09110
gene id: 53952:A0127_RS09110
uniprot id: A0A142CX05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

53952:A0127 RS02520
gene id: 53952:A0127_RS02520
uniprot id: A0A142CTL9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

53952:A0127 RS04825
gene id: 53952:A0127_RS04825
uniprot id: A0A142CUT6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

53952:A0127 RS08140
gene id: 53952:A0127_RS08140
uniprot id: A0A142CWI2
names: Similarity
messages: Belongs to the thymidylate kinase family.

53952:A0127 RS02100
gene id: 53952:A0127_RS02100
uniprot id: A0A142CTE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

53952:A0127 RS03140
gene id: 53952:A0127_RS03140
uniprot id: A0A142CTY1
names: Similarity
messages: Belongs to the GbsR family.

53952:A0127 RS01215
gene id: 53952:A0127_RS01215
uniprot id: A0A142CSY5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

53952:A0127 RS02970
gene id: 53952:A0127_RS02970
uniprot id: A0A142CTU7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

53952:A0127 RS06815
gene id: 53952:A0127_RS06815
uniprot id: A0A142CVU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Monomer.
messages: Serine protease with a broad substrate specificity.

53952:A0127 RS04900
gene id: 53952:A0127_RS04900
uniprot id: A0A142CUU6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

53952:A0127 RS00585
gene id: 53952:A0127_RS00585
uniprot id: A0A142CSL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

53952:A0127 RS02125
gene id: 53952:A0127_RS02125
uniprot id: A0A142CTF1
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS09530
gene id: 53952:A0127_RS09530
uniprot id: A0A142CX80
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

53952:A0127 RS01180
gene id: 53952:A0127_RS01180
uniprot id: A0A142CSX9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

53952:A0127 RS03770
gene id: 53952:A0127_RS03770
uniprot id: A0A142CU99
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS09380
gene id: 53952:A0127_RS09380
uniprot id: A0A142CX53
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01965
gene id: 53952:A0127_RS01965
uniprot id: A0A142CTC1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

53952:A0127 RS06140
gene id: 53952:A0127_RS06140
uniprot id: A0A142CVH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

53952:A0127 RS07265
gene id: 53952:A0127_RS07265
uniprot id: A0A142CW31
names: Function
messages: Part of a potassium transport system.

53952:A0127 RS07035
gene id: 53952:A0127_RS07035
uniprot id: A0A142CVY7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

53952:A0127 RS00910
gene id: 53952:A0127_RS00910
uniprot id: A0A142CST4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

53952:A0127 RS00580
gene id: 53952:A0127_RS00580
uniprot id: A0A142CSL8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

53952:A0127 RS06160
gene id: 53952:A0127_RS06160
uniprot id: A0A142CVI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS05745
gene id: 53952:A0127_RS05745
uniprot id: A0A142CXM3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

53952:A0127 RS04230
gene id: 53952:A0127_RS04230
uniprot id: A0A142CUI1
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

53952:A0127 RS02070
gene id: 53952:A0127_RS02070
uniprot id: A0A142CTE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS03870
gene id: 53952:A0127_RS03870
uniprot id: A0A142CUB8
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

53952:A0127 RS08665
gene id: 53952:A0127_RS08665
uniprot id: A0A142CWS6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

53952:A0127 RS01130
gene id: 53952:A0127_RS01130
uniprot id: A0A142CXI5
names: Similarity
messages: Belongs to the UPF0179 family.

53952:A0127 RS03675
gene id: 53952:A0127_RS03675
uniprot id: A0A142CU83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

53952:A0127 RS04675
gene id: 53952:A0127_RS04675
uniprot id: A0A142CUR0
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

53952:A0127 RS07275
gene id: 53952:A0127_RS07275
uniprot id: A0A142CW33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

53952:A0127 RS03995
gene id: 53952:A0127_RS03995
uniprot id: A0A142CUE2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS02950
gene id: 53952:A0127_RS02950
uniprot id: A0A142CTU3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

53952:A0127 RS03500
gene id: 53952:A0127_RS03500
uniprot id: A0A142CU50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

53952:A0127 RS01820
gene id: 53952:A0127_RS01820
uniprot id: A0A142CT94
names: Similarity
messages: Belongs to the peptidase U62 family.

53952:A0127 RS06770
gene id: 53952:A0127_RS06770
uniprot id: A0A142CVU0
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

53952:A0127 RS09255
gene id: 53952:A0127_RS09255
uniprot id: A0A142CX30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

53952:A0127 RS02005
gene id: 53952:A0127_RS02005
uniprot id: A0A142CTC9
names: Similarity
messages: Belongs to the UPF0284 family.

53952:A0127 RS09950
gene id: 53952:A0127_RS09950
uniprot id: A0A142CXF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS00885
gene id: 53952:A0127_RS00885
uniprot id: A0A142CSS9
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

53952:A0127 RS04730
gene id: 53952:A0127_RS04730
uniprot id: A0A142CUR8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

53952:A0127 RS06100
gene id: 53952:A0127_RS06100
uniprot id: A0A142CVG9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

53952:A0127 RS04820
gene id: 53952:A0127_RS04820
uniprot id: A0A142CUT5
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS04170
gene id: 53952:A0127_RS04170
uniprot id: A0A142CUH3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS00745
gene id: 53952:A0127_RS00745
uniprot id: A0A142CSQ1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

53952:A0127 RS08075
gene id: 53952:A0127_RS08075
uniprot id: A0A142CWH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

53952:A0127 RS09035
gene id: 53952:A0127_RS09035
uniprot id: A0A142CWZ2
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01195
gene id: 53952:A0127_RS01195
uniprot id: A0A142CSY1
names: Similarity
messages: Belongs to the SfsA family.

53952:A0127 RS02810
gene id: 53952:A0127_RS02810
uniprot id: A0A142CTR9
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS02935
gene id: 53952:A0127_RS02935
uniprot id: A0A142CTU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

53952:A0127 RS08855
gene id: 53952:A0127_RS08855
uniprot id: A0A142CXQ9
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

53952:A0127 RS05555
gene id: 53952:A0127_RS05555
uniprot id: A0A142CV69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS03765
gene id: 53952:A0127_RS03765
uniprot id: A0A142CU98
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

53952:A0127 RS05740
gene id: 53952:A0127_RS05740
uniprot id: A0A142CVA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

53952:A0127 RS08510
gene id: 53952:A0127_RS08510
uniprot id: A0A142CWP6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

53952:A0127 RS09485
gene id: 53952:A0127_RS09485
uniprot id: A0A142CX71
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS06665
gene id: 53952:A0127_RS06665
uniprot id: A0A142CVS3
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

53952:A0127 RS08130
gene id: 53952:A0127_RS08130
uniprot id: A0A142CWI1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS08360
gene id: 53952:A0127_RS08360
uniprot id: A0A142CWL8
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

53952:A0127 RS02350
gene id: 53952:A0127_RS02350
uniprot id: A0A142CTI9
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

53952:A0127 RS03420
gene id: 53952:A0127_RS03420
uniprot id: A0A142CU34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

53952:A0127 RS07030
gene id: 53952:A0127_RS07030
uniprot id: A0A142CVY6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

53952:A0127 RS04095
gene id: 53952:A0127_RS04095
uniprot id: A0A142CUF8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

53952:A0127 RS09390
gene id: 53952:A0127_RS09390
uniprot id: A0A142CX55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS07540
gene id: 53952:A0127_RS07540
uniprot id: A0A142CW78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

53952:A0127 RS01700
gene id: 53952:A0127_RS01700
uniprot id: A0A142CT70
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

53952:A0127 RS07795
gene id: 53952:A0127_RS07795
uniprot id: A0A142CWC2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

53952:A0127 RS08065
gene id: 53952:A0127_RS08065
uniprot id: A0A142CWG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

53952:A0127 RS08525
gene id: 53952:A0127_RS08525
uniprot id: A0A142CWP9
names: Similarity
messages: Belongs to the PDCD5 family.

53952:A0127 RS04330
gene id: 53952:A0127_RS04330
uniprot id: A0A142CUK0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

53952:A0127 RS03120
gene id: 53952:A0127_RS03120
uniprot id: A0A142CTX7
names: Similarity
messages: Belongs to the UPF0045 family.

53952:A0127 RS06085
gene id: 53952:A0127_RS06085
uniprot id: A0A142CVG6
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

53952:A0127 RS06870
gene id: 53952:A0127_RS06870
uniprot id: A0A142CVV6
names: Similarity
messages: Belongs to the peptidase S8 family.

53952:A0127 RS05000
gene id: 53952:A0127_RS05000
uniprot id: A0A142CUW4
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

53952:A0127 RS05530
gene id: 53952:A0127_RS05530
uniprot id: A0A142CV64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

53952:A0127 RS06780
gene id: 53952:A0127_RS06780
uniprot id: A0A142CVU2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS04565
gene id: 53952:A0127_RS04565
uniprot id: A0A142CUP0
names: Similarity
messages: Belongs to the UPF0145 family.

53952:A0127 RS05875
gene id: 53952:A0127_RS05875
uniprot id: A0A142CVC7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

53952:A0127 RS01205
gene id: 53952:A0127_RS01205
uniprot id: A0A142CSY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

53952:A0127 RS00960
gene id: 53952:A0127_RS00960
uniprot id: A0A142CXI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

53952:A0127 RS06590
gene id: 53952:A0127_RS06590
uniprot id: A0A142CVR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

53952:A0127 RS01970
gene id: 53952:A0127_RS01970
uniprot id: A0A142CTC2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

53952:A0127 RS09365
gene id: 53952:A0127_RS09365
uniprot id: A0A142CX51
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

53952:A0127 RS00535
gene id: 53952:A0127_RS00535
uniprot id: A0A142CSK9
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

53952:A0127 RS04260
gene id: 53952:A0127_RS04260
uniprot id: A0A142CUI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

53952:A0127 RS05395
gene id: 53952:A0127_RS05395
uniprot id: A0A142CV38
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

53952:A0127 RS02550
gene id: 53952:A0127_RS02550
uniprot id: A0A142CTM4
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

53952:A0127 RS01550
gene id: 53952:A0127_RS01550
uniprot id: A0A142CXJ0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

53952:A0127 RS00250
gene id: 53952:A0127_RS00250
uniprot id: A0A142CSF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS08810
gene id: 53952:A0127_RS08810
uniprot id: A0A142CWV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS03375
gene id: 53952:A0127_RS03375
uniprot id: A0A142CU25
names: Similarity
messages: Belongs to the UPF0173 family.

53952:A0127 RS06080
gene id: 53952:A0127_RS06080
uniprot id: A0A142CVG5
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS03160
gene id: 53952:A0127_RS03160
uniprot id: A0A142CTY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

53952:A0127 RS03575
gene id: 53952:A0127_RS03575
uniprot id: A0A142CU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

53952:A0127 RS03935
gene id: 53952:A0127_RS03935
uniprot id: A0A142CUD1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

53952:A0127 RS01805
gene id: 53952:A0127_RS01805
uniprot id: A0A142CT91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

53952:A0127 RS09710
gene id: 53952:A0127_RS09710
uniprot id: A0A142CXB1
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05325
gene id: 53952:A0127_RS05325
uniprot id: A0A142CV25
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05880
gene id: 53952:A0127_RS05880
uniprot id: A0A142CVC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

53952:A0127 RS06290
gene id: 53952:A0127_RS06290
uniprot id: A0A142CVK4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

53952:A0127 RS02540
gene id: 53952:A0127_RS02540
uniprot id: A0A142CTM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

53952:A0127 RS03405
gene id: 53952:A0127_RS03405
uniprot id: A0A142CU31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

53952:A0127 RS03025
gene id: 53952:A0127_RS03025
uniprot id: A0A142CTV8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

53952:A0127 RS04275
gene id: 53952:A0127_RS04275
uniprot id: A0A142CUJ0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

53952:A0127 RS07350
gene id: 53952:A0127_RS07350
uniprot id: A0A142CW43
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

53952:A0127 RS08480
gene id: 53952:A0127_RS08480
uniprot id: A0A142CWP0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

53952:A0127 RS07205
gene id: 53952:A0127_RS07205
uniprot id: A0A142CW19
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

53952:A0127 RS05785
gene id: 53952:A0127_RS05785
uniprot id: A0A142CVA9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS04300
gene id: 53952:A0127_RS04300
uniprot id: A0A142CUJ4
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

53952:A0127 RS08405
gene id: 53952:A0127_RS08405
uniprot id: A0A142CWM7
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

53952:A0127 RS06460
gene id: 53952:A0127_RS06460
uniprot id: A0A142CVN7
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

53952:A0127 RS00670
gene id: 53952:A0127_RS00670
uniprot id: A0A142CSN6
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

53952:A0127 RS05600
gene id: 53952:A0127_RS05600
uniprot id: A0A142CV76
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

53952:A0127 RS09830
gene id: 53952:A0127_RS09830
uniprot id: A0A142CXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

53952:A0127 RS02170
gene id: 53952:A0127_RS02170
uniprot id: A0A142CTF9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

53952:A0127 RS02255
gene id: 53952:A0127_RS02255
uniprot id: A0A142CTH3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

53952:A0127 RS05755
gene id: 53952:A0127_RS05755
uniprot id: A0A142CVA4
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

53952:A0127 RS03245
gene id: 53952:A0127_RS03245
uniprot id: A0A142CU00
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

53952:A0127 RS04325
gene id: 53952:A0127_RS04325
uniprot id: A0A142CUJ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

53952:A0127 RS00780
gene id: 53952:A0127_RS00780
uniprot id: A0A142CSQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

53952:A0127 RS04680
gene id: 53952:A0127_RS04680
uniprot id: A0A142CUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

53952:A0127 RS06845
gene id: 53952:A0127_RS06845
uniprot id: A0A142CVV1
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

53952:A0127 RS01560
gene id: 53952:A0127_RS01560
uniprot id: A0A142CT46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

53952:A0127 RS07500
gene id: 53952:A0127_RS07500
uniprot id: A0A142CXP5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

53952:A0127 RS08420
gene id: 53952:A0127_RS08420
uniprot id: A0A142CWN0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

53952:A0127 RS05320
gene id: 53952:A0127_RS05320
uniprot id: A0A142CV24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS01640
gene id: 53952:A0127_RS01640
uniprot id: A0A142CT61
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS06350
gene id: 53952:A0127_RS06350
uniprot id: A0A142CVL6
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

53952:A0127 RS10130
gene id: 53952:A0127_RS10130
uniprot id: A0A142CXT3
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS09740
gene id: 53952:A0127_RS09740
uniprot id: A0A142CXB7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

53952:A0127 RS08235
gene id: 53952:A0127_RS08235
uniprot id: A0A142CWJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

53952:A0127 RS04105
gene id: 53952:A0127_RS04105
uniprot id: A0A142CUG0
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

53952:A0127 RS09780
gene id: 53952:A0127_RS09780
uniprot id: A0A142CXC4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

53952:A0127 RS08430
gene id: 53952:A0127_RS08430
uniprot id: A0A142CWN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

53952:A0127 RS08830
gene id: 53952:A0127_RS08830
uniprot id: A0A142CXQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS01080
gene id: 53952:A0127_RS01080
uniprot id: A0A142CSW4
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

53952:A0127 RS04075
gene id: 53952:A0127_RS04075
uniprot id: A0A142CUF4
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

53952:A0127 RS04925
gene id: 53952:A0127_RS04925
uniprot id: A0A142CUV1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

53952:A0127 RS00555
gene id: 53952:A0127_RS00555
uniprot id: A0A142CSL3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

53952:A0127 RS07480
gene id: 53952:A0127_RS07480
uniprot id: A0A142CW67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

53952:A0127 RS00030
gene id: 53952:A0127_RS00030
uniprot id: A0A142CSB5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

53952:A0127 RS01040
gene id: 53952:A0127_RS01040
uniprot id: A0A142CSV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

53952:A0127 RS01595
gene id: 53952:A0127_RS01595
uniprot id: A0A142CT52
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

53952:A0127 RS03595
gene id: 53952:A0127_RS03595
uniprot id: A0A142CU67
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS07235
gene id: 53952:A0127_RS07235
uniprot id: A0A142CW25
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

53952:A0127 RS01730
gene id: 53952:A0127_RS01730
uniprot id: A0A142CT76
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS07620
gene id: 53952:A0127_RS07620
uniprot id: A0A142CW94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

53952:A0127 RS07580
gene id: 53952:A0127_RS07580
uniprot id: A0A142CW86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

53952:A0127 RS08465
gene id: 53952:A0127_RS08465
uniprot id: A0A142CWN7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

53952:A0127 RS03600
gene id: 53952:A0127_RS03600
uniprot id: A0A142CU68
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

53952:A0127 RS05430
gene id: 53952:A0127_RS05430
uniprot id: A0A142CV45
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS04840
gene id: 53952:A0127_RS04840
uniprot id: A0A142CUT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

53952:A0127 RS07515
gene id: 53952:A0127_RS07515
uniprot id: A0A142CW73
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

53952:A0127 RS06905
gene id: 53952:A0127_RS06905
uniprot id: A0A142CVW3
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS02750
gene id: 53952:A0127_RS02750
uniprot id: A0A142CTQ7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS01340
gene id: 53952:A0127_RS01340
uniprot id: A0A142CT07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

53952:A0127 RS08265
gene id: 53952:A0127_RS08265
uniprot id: A0A142CWK0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

53952:A0127 RS01225
gene id: 53952:A0127_RS01225
uniprot id: A0A142CSY7
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS06195
gene id: 53952:A0127_RS06195
uniprot id: A0A142CVI7
names: Similarity
messages: Belongs to the UPF0216 family.

53952:A0127 RS07610
gene id: 53952:A0127_RS07610
uniprot id: A0A142CW92
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS03930
gene id: 53952:A0127_RS03930
uniprot id: A0A142CUD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

53952:A0127 RS06115
gene id: 53952:A0127_RS06115
uniprot id: A0A142CVH2
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

53952:A0127 RS07290
gene id: 53952:A0127_RS07290
uniprot id: A0A142CW34
names: Similarity
messages: Belongs to the UPF0273 family.

53952:A0127 RS02225
gene id: 53952:A0127_RS02225
uniprot id: A0A142CTG8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

53952:A0127 RS07110
gene id: 53952:A0127_RS07110
uniprot id: A0A142CW01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

53952:A0127 RS07640
gene id: 53952:A0127_RS07640
uniprot id: A0A142CW98
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

53952:A0127 RS08070
gene id: 53952:A0127_RS08070
uniprot id: A0A142CWH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

53952:A0127 RS07665
gene id: 53952:A0127_RS07665
uniprot id: A0A142CWA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

53952:A0127 RS07495
gene id: 53952:A0127_RS07495
uniprot id: A0A142CW70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

53952:A0127 RS04615
gene id: 53952:A0127_RS04615
uniprot id: A0A142CUP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

53952:A0127 RS07720
gene id: 53952:A0127_RS07720
uniprot id: A0A142CXP6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

53952:A0127 RS00595
gene id: 53952:A0127_RS00595
uniprot id: A0A142CSM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

53952:A0127 RS03415
gene id: 53952:A0127_RS03415
uniprot id: A0A142CU33
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

53952:A0127 RS03905
gene id: 53952:A0127_RS03905
uniprot id: A0A142CUC5
names: Similarity
messages: Belongs to the UPF0128 family.

53952:A0127 RS03640
gene id: 53952:A0127_RS03640
uniprot id: A0A142CU76
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS07955
gene id: 53952:A0127_RS07955
uniprot id: A0A142CWF0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

53952:A0127 RS07820
gene id: 53952:A0127_RS07820
uniprot id: A0A142CXP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

53952:A0127 RS00760
gene id: 53952:A0127_RS00760
uniprot id: A0A142CSQ4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

53952:A0127 RS09290
gene id: 53952:A0127_RS09290
uniprot id: A0A142CX37
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

53952:A0127 RS02730
gene id: 53952:A0127_RS02730
uniprot id: A0A142CTQ6
names: Similarity
messages: Belongs to the DEAD box helicase family.

53952:A0127 RS02715
gene id: 53952:A0127_RS02715
uniprot id: A0A142CTQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

53952:A0127 RS05550
gene id: 53952:A0127_RS05550
uniprot id: A0A142CV68
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05080
gene id: 53952:A0127_RS05080
uniprot id: A0A142CXL9
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS05735
gene id: 53952:A0127_RS05735
uniprot id: A0A142CVA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

53952:A0127 RS08590
gene id: 53952:A0127_RS08590
uniprot id: A0A142CWR2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS05285
gene id: 53952:A0127_RS05285
uniprot id: A0A142CXM1
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

53952:A0127 RS00165
gene id: 53952:A0127_RS00165
uniprot id: A0A142CSD9
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS07730
gene id: 53952:A0127_RS07730
uniprot id: A0A142CWB1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

53952:A0127 RS07550
gene id: 53952:A0127_RS07550
uniprot id: A0A142CW80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

53952:A0127 RS02385
gene id: 53952:A0127_RS02385
uniprot id: A0A142CTJ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS05065
gene id: 53952:A0127_RS05065
uniprot id: A0A142CUX7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

53952:A0127 RS02785
gene id: 53952:A0127_RS02785
uniprot id: A0A142CTR4
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

53952:A0127 RS03460
gene id: 53952:A0127_RS03460
uniprot id: A0A142CU42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

53952:A0127 RS03360
gene id: 53952:A0127_RS03360
uniprot id: A0A142CU22
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

53952:A0127 RS00270
gene id: 53952:A0127_RS00270
uniprot id: A0A142CSF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

53952:A0127 RS05310
gene id: 53952:A0127_RS05310
uniprot id: A0A142CV22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS01085
gene id: 53952:A0127_RS01085
uniprot id: A0A142CSW5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

53952:A0127 RS07625
gene id: 53952:A0127_RS07625
uniprot id: A0A142CW95
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

53952:A0127 RS06690
gene id: 53952:A0127_RS06690
uniprot id: A0A142CVS8
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

53952:A0127 RS00565
gene id: 53952:A0127_RS00565
uniprot id: A0A142CSL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

53952:A0127 RS04435
gene id: 53952:A0127_RS04435
uniprot id: A0A142CUL7
names: Similarity
messages: Belongs to the BtpA family.

53952:A0127 RS02570
gene id: 53952:A0127_RS02570
uniprot id: A0A142CTM8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

53952:A0127 RS09080
gene id: 53952:A0127_RS09080
uniprot id: A0A142CXR2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS09405
gene id: 53952:A0127_RS09405
uniprot id: A0A142CX58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS08475
gene id: 53952:A0127_RS08475
uniprot id: A0A142CWN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

53952:A0127 RS09735
gene id: 53952:A0127_RS09735
uniprot id: A0A142CXB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

53952:A0127 RS08490
gene id: 53952:A0127_RS08490
uniprot id: A0A142CWP2
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

53952:A0127 RS06145
gene id: 53952:A0127_RS06145
uniprot id: A0A142CVH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

53952:A0127 RS08990
gene id: 53952:A0127_RS08990
uniprot id: A0A142CWY4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS04360
gene id: 53952:A0127_RS04360
uniprot id: A0A142CUK6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

53952:A0127 RS04065
gene id: 53952:A0127_RS04065
uniprot id: A0A142CUF3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS09160
gene id: 53952:A0127_RS09160
uniprot id: A0A142CX14
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

53952:A0127 RS02645
gene id: 53952:A0127_RS02645
uniprot id: A0A142CTP2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

53952:A0127 RS09135
gene id: 53952:A0127_RS09135
uniprot id: A0A142CX09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

53952:A0127 RS02345
gene id: 53952:A0127_RS02345
uniprot id: A0A142CTI8
names: Similarity
messages: Belongs to the arginase family.

53952:A0127 RS05940
gene id: 53952:A0127_RS05940
uniprot id: A0A142CVE0
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS08000
gene id: 53952:A0127_RS08000
uniprot id: A0A142CWF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

53952:A0127 RS03970
gene id: 53952:A0127_RS03970
uniprot id: A0A142CUD7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

53952:A0127 RS01135
gene id: 53952:A0127_RS01135
uniprot id: A0A142CXI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

53952:A0127 RS09880
gene id: 53952:A0127_RS09880
uniprot id: A0A142CXE4
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS02240
gene id: 53952:A0127_RS02240
uniprot id: A0A142CTH0
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

53952:A0127 RS08085
gene id: 53952:A0127_RS08085
uniprot id: A0A142CWH2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS04045
gene id: 53952:A0127_RS04045
uniprot id: A0A142CUF1
names: Similarity
messages: Belongs to the UPF0252 family.

53952:A0127 RS08045
gene id: 53952:A0127_RS08045
uniprot id: A0A142CWG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

53952:A0127 RS03860
gene id: 53952:A0127_RS03860
uniprot id: A0A142CUB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

53952:A0127 RS03845
gene id: 53952:A0127_RS03845
uniprot id: A0A142CUB3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

53952:A0127 RS03030
gene id: 53952:A0127_RS03030
uniprot id: A0A142CTV9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

53952:A0127 RS07255
gene id: 53952:A0127_RS07255
uniprot id: A0A142CW29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

53952:A0127 RS07170
gene id: 53952:A0127_RS07170
uniprot id: A0A142CW12
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

53952:A0127 RS03915
gene id: 53952:A0127_RS03915
uniprot id: A0A142CUC7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

53952:A0127 RS04610
gene id: 53952:A0127_RS04610
uniprot id: A0A142CUP7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

53952:A0127 RS00240
gene id: 53952:A0127_RS00240
uniprot id: A0A142CSF3
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

53952:A0127 RS06455
gene id: 53952:A0127_RS06455
uniprot id: A0A142CVN6
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01930
gene id: 53952:A0127_RS01930
uniprot id: A0A142CTB4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

53952:A0127 RS08335
gene id: 53952:A0127_RS08335
uniprot id: A0A142CWL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

53952:A0127 RS02930
gene id: 53952:A0127_RS02930
uniprot id: A0A142CTT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

53952:A0127 RS03270
gene id: 53952:A0127_RS03270
uniprot id: A0A142CU05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

53952:A0127 RS07905
gene id: 53952:A0127_RS07905
uniprot id: A0A142CWE0
names: Similarity
messages: Belongs to the peptidase M24B family.

53952:A0127 RS08585
gene id: 53952:A0127_RS08585
uniprot id: A0A142CWR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

53952:A0127 RS03230
gene id: 53952:A0127_RS03230
uniprot id: A0A142CTZ7
names: Similarity
messages: Belongs to the DtxR/MntR family.

53952:A0127 RS02490
gene id: 53952:A0127_RS02490
uniprot id: A0A142CTL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

53952:A0127 RS07310
gene id: 53952:A0127_RS07310
uniprot id: A0A142CW36
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

53952:A0127 RS04305
gene id: 53952:A0127_RS04305
uniprot id: A0A142CUJ5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

53952:A0127 RS04905
gene id: 53952:A0127_RS04905
uniprot id: A0A142CUU7
names: Similarity
messages: Belongs to the UPF0111 family.

53952:A0127 RS09445
gene id: 53952:A0127_RS09445
uniprot id: A0A142CX63
names: Similarity
messages: Belongs to the HupF/HypC family.

53952:A0127 RS06370
gene id: 53952:A0127_RS06370
uniprot id: A0A142CVM0
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

53952:A0127 RS03755
gene id: 53952:A0127_RS03755
uniprot id: A0A142CU96
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

53952:A0127 RS00835
gene id: 53952:A0127_RS00835
uniprot id: A0A142CSR9
names: Similarity
messages: Belongs to the AOR/FOR family.

53952:A0127 RS07560
gene id: 53952:A0127_RS07560
uniprot id: A0A142CW82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

53952:A0127 RS04755
gene id: 53952:A0127_RS04755
uniprot id: A0A142CUS3
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

53952:A0127 RS00210
gene id: 53952:A0127_RS00210
uniprot id: A0A142CXH9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

53952:A0127 RS07520
gene id: 53952:A0127_RS07520
uniprot id: A0A142CW74
names: Similarity
messages: Belongs to the SUI1 family.

53952:A0127 RS01635
gene id: 53952:A0127_RS01635
uniprot id: A0A142CT60
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01030
gene id: 53952:A0127_RS01030
uniprot id: A0A142CSV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

53952:A0127 RS01565
gene id: 53952:A0127_RS01565
uniprot id: A0A142CT47
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

53952:A0127 RS02260
gene id: 53952:A0127_RS02260
uniprot id: A0A142CTH4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS08470
gene id: 53952:A0127_RS08470
uniprot id: A0A142CWN8
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS07740
gene id: 53952:A0127_RS07740
uniprot id: A0A142CWB3
names: Similarity
messages: Belongs to the FUN14 family.

53952:A0127 RS08885
gene id: 53952:A0127_RS08885
uniprot id: A0A142CWW3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

53952:A0127 RS02805
gene id: 53952:A0127_RS02805
uniprot id: A0A142CTR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

53952:A0127 RS01945
gene id: 53952:A0127_RS01945
uniprot id: A0A142CTB7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

53952:A0127 RS01855
gene id: 53952:A0127_RS01855
uniprot id: A0A142CTA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

53952:A0127 RS05330
gene id: 53952:A0127_RS05330
uniprot id: A0A142CV26
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS00230
gene id: 53952:A0127_RS00230
uniprot id: A0A142CSF1
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

53952:A0127 RS01545
gene id: 53952:A0127_RS01545
uniprot id: A0A142CT44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

53952:A0127 RS07120
gene id: 53952:A0127_RS07120
uniprot id: A0A142CW02
names: Subcellular Location Annotation
messages: Nucleus

53952:A0127 RS02155
gene id: 53952:A0127_RS02155
uniprot id: A0A142CTF6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS02670
gene id: 53952:A0127_RS02670
uniprot id: A0A142CTP6
names: Function
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

53952:A0127 RS06190
gene id: 53952:A0127_RS06190
uniprot id: A0A142CVI6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

53952:A0127 RS03555
gene id: 53952:A0127_RS03555
uniprot id: A0A142CU60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

53952:A0127 RS04120
gene id: 53952:A0127_RS04120
uniprot id: A0A142CUG3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

53952:A0127 RS06800
gene id: 53952:A0127_RS06800
uniprot id: A0A142CVU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

53952:A0127 RS04785
gene id: 53952:A0127_RS04785
uniprot id: A0A142CUS8
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01065
gene id: 53952:A0127_RS01065
uniprot id: A0A142CSW1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

53952:A0127 RS08555
gene id: 53952:A0127_RS08555
uniprot id: A0A142CWQ5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

53952:A0127 RS08040
gene id: 53952:A0127_RS08040
uniprot id: A0A142CWG4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

53952:A0127 RS09100
gene id: 53952:A0127_RS09100
uniprot id: A0A142CX03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

53952:A0127 RS05215
gene id: 53952:A0127_RS05215
uniprot id: A0A142CV05
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS01705
gene id: 53952:A0127_RS01705
uniprot id: A0A142CT71
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

53952:A0127 RS00365
gene id: 53952:A0127_RS00365
uniprot id: A0A142CSH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

53952:A0127 RS01665
gene id: 53952:A0127_RS01665
uniprot id: A0A142CT65
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS07450
gene id: 53952:A0127_RS07450
uniprot id: A0A142CW62
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

53952:A0127 RS00330
gene id: 53952:A0127_RS00330
uniprot id: A0A142CSH0
names: Similarity
messages: Belongs to the HypE family.

53952:A0127 RS04795
gene id: 53952:A0127_RS04795
uniprot id: A0A142CUT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

53952:A0127 RS04010
gene id: 53952:A0127_RS04010
uniprot id: A0A142CUE5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS06430
gene id: 53952:A0127_RS06430
uniprot id: A0A142CVN1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

53952:A0127 RS09885
gene id: 53952:A0127_RS09885
uniprot id: A0A142CXE5
names: Similarity
messages: Belongs to the AOR/FOR family.

53952:A0127 RS04995
gene id: 53952:A0127_RS04995
uniprot id: A0A142CUW3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

53952:A0127 RS05545
gene id: 53952:A0127_RS05545
uniprot id: A0A142CV67
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

53952:A0127 RS07685
gene id: 53952:A0127_RS07685
uniprot id: A0A142CWA5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

53952:A0127 RS09070
gene id: 53952:A0127_RS09070
uniprot id: A0A142CWZ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

53952:A0127 RS09675
gene id: 53952:A0127_RS09675
uniprot id: A0A142CXA4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

53952:A0127 RS08400
gene id: 53952:A0127_RS08400
uniprot id: A0A142CWM6
names: Similarity
messages: Belongs to the HypE family.

53952:A0127 RS04245
gene id: 53952:A0127_RS04245
uniprot id: A0A142CUI4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS08865
gene id: 53952:A0127_RS08865
uniprot id: A0A142CWV9
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

53952:A0127 RS03975
gene id: 53952:A0127_RS03975
uniprot id: A0A142CUD8
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

53952:A0127 RS00650
gene id: 53952:A0127_RS00650
uniprot id: A0A142CSN2
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS03630
gene id: 53952:A0127_RS03630
uniprot id: A0A142CU74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

53952:A0127 RS08445
gene id: 53952:A0127_RS08445
uniprot id: A0A142CXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

53952:A0127 RS05750
gene id: 53952:A0127_RS05750
uniprot id: A0A142CVA3
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS07700
gene id: 53952:A0127_RS07700
uniprot id: A0A142CWA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

53952:A0127 RS08515
gene id: 53952:A0127_RS08515
uniprot id: A0A142CWP7
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

53952:A0127 RS06785
gene id: 53952:A0127_RS06785
uniprot id: A0A142CVU3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

53952:A0127 RS03475
gene id: 53952:A0127_RS03475
uniprot id: A0A142CU45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS00400
gene id: 53952:A0127_RS00400
uniprot id: A0A142CSI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

53952:A0127 RS05050
gene id: 53952:A0127_RS05050
uniprot id: A0A142CUX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

53952:A0127 RS03780
gene id: 53952:A0127_RS03780
uniprot id: A0A142CUA1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

53952:A0127 RS04775
gene id: 53952:A0127_RS04775
uniprot id: A0A142CUS6
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

53952:A0127 RS08560
gene id: 53952:A0127_RS08560
uniprot id: A0A142CWQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

53952:A0127 RS05090
gene id: 53952:A0127_RS05090
uniprot id: A0A142CUY1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

53952:A0127 RS02440
gene id: 53952:A0127_RS02440
uniprot id: A0A142CTK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

53952:A0127 RS05110
gene id: 53952:A0127_RS05110
uniprot id: A0A142CUY5
names: Similarity
messages: Belongs to the UPF0215 family.

53952:A0127 RS03680
gene id: 53952:A0127_RS03680
uniprot id: A0A142CU84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

53952:A0127 RS09095
gene id: 53952:A0127_RS09095
uniprot id: A0A142CX02
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS09615
gene id: 53952:A0127_RS09615
uniprot id: A0A142CX93
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS00025
gene id: 53952:A0127_RS00025
uniprot id: A0A142CSB4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

53952:A0127 RS00505
gene id: 53952:A0127_RS00505
uniprot id: A0A142CSK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

53952:A0127 RS05815
gene id: 53952:A0127_RS05815
uniprot id: A0A142CVB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

53952:A0127 RS04405
gene id: 53952:A0127_RS04405
uniprot id: A0A142CUL2
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

53952:A0127 RS06755
gene id: 53952:A0127_RS06755
uniprot id: A0A142CVT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

53952:A0127 RS01530
gene id: 53952:A0127_RS01530
uniprot id: A0A142CT41
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

53952:A0127 RS07780
gene id: 53952:A0127_RS07780
uniprot id: A0A142CWB9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

53952:A0127 RS02140
gene id: 53952:A0127_RS02140
uniprot id: A0A142CTF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS07045
gene id: 53952:A0127_RS07045
uniprot id: A0A142CVY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

53952:A0127 RS04655
gene id: 53952:A0127_RS04655
uniprot id: A0A142CUQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

53952:A0127 RS09665
gene id: 53952:A0127_RS09665
uniprot id: A0A142CXA2
names: Similarity
messages: Belongs to the AOR/FOR family.

53952:A0127 RS01660
gene id: 53952:A0127_RS01660
uniprot id: A0A142CT64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

53952:A0127 RS03865
gene id: 53952:A0127_RS03865
uniprot id: A0A142CUB7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

53952:A0127 RS00215
gene id: 53952:A0127_RS00215
uniprot id: A0A142CSE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

53952:A0127 RS07975
gene id: 53952:A0127_RS07975
uniprot id: A0A142CWF4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

53952:A0127 RS08315
gene id: 53952:A0127_RS08315
uniprot id: A0A142CWK9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

53952:A0127 RS08740
gene id: 53952:A0127_RS08740
uniprot id: A0A142CWT8
names: Subunit
messages: Homotetramer.

53952:A0127 RS07630
gene id: 53952:A0127_RS07630
uniprot id: A0A142CW96
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

53952:A0127 RS01720
gene id: 53952:A0127_RS01720
uniprot id: A0A142CT74
names: Similarity
messages: Belongs to the IMPACT family.

53952:A0127 RS09625
gene id: 53952:A0127_RS09625
uniprot id: A0A142CX95
names: Similarity
messages: Belongs to the AOR/FOR family.

53952:A0127 RS03340
gene id: 53952:A0127_RS03340
uniprot id: A0A142CU18
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

53952:A0127 RS07660
gene id: 53952:A0127_RS07660
uniprot id: A0A142CWA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

53952:A0127 RS00325
gene id: 53952:A0127_RS00325
uniprot id: A0A142CSG9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

53952:A0127 RS05355
gene id: 53952:A0127_RS05355
uniprot id: A0A142CV31
names: Subcellular Location Annotation
messages: Membrane

53952:A0127 RS03000
gene id: 53952:A0127_RS03000
uniprot id: A0A142CTV3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

53952:A0127 RS10315
gene id: 53952:A0127_RS10315
uniprot id: A0A142CXW2
names: Subcellular Location Annotation
messages: Cytoplasm

53952:A0127 RS01485
gene id: 53952:A0127_RS01485
uniprot id: A0A142CT32
names: Similarity
messages: Belongs to the peptidase U62 family.

53952:A0127 RS01285
gene id: 53952:A0127_RS01285
uniprot id: A0A142CSZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

53952:A0127 RS03785
gene id: 53952:A0127_RS03785
uniprot id: A0A142CUA2
names: Subunit
messages: Homodimer.

53952:A0127 RS07005
gene id: 53952:A0127_RS07005
uniprot id: A0A142CVY2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

53952:A0127 RS09810
gene id: 53952:A0127_RS09810
uniprot id: A0A142CXD0
names: Similarity
messages: Belongs to the glutaredoxin family.

53952:A0127 RS00820
gene id: 53952:A0127_RS00820
uniprot id: A0A142CSR6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

53952:A0127 RS09450
gene id: 53952:A0127_RS09450
uniprot id: A0A142CX64
names: Similarity
messages: Belongs to the HupF/HypC family.

53952:A0127 RS09840
gene id: 53952:A0127_RS09840
uniprot id: A0A142CXD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

53952:A0127 RS07155
gene id: 53952:A0127_RS07155
uniprot id: A0A142CW09
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

53952:A0127 RS04350
gene id: 53952:A0127_RS04350
uniprot id: A0A142CUK4
names: Similarity
messages: Belongs to the UPF0047 family.

53952:A0127 RS07855
gene id: 53952:A0127_RS07855
uniprot id: A0A142CWD0
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

53952:A0127 RS02795
gene id: 53952:A0127_RS02795
uniprot id: A0A142CTR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

53952:A0127 RS03010
gene id: 53952:A0127_RS03010
uniprot id: A0A142CTV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

53952:A0127 RS07140
gene id: 53952:A0127_RS07140
uniprot id: A0A142CW06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

53952:A0127 RS08435
gene id: 53952:A0127_RS08435
uniprot id: A0A142CXQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

53952:A0127 RS04025
gene id: 53952:A0127_RS04025
uniprot id: A0A142CUE8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

53952:A0127 RS01960
gene id: 53952:A0127_RS01960
uniprot id: A0A142CTC0
names: Similarity
messages: Belongs to the NodU/CmcH family.

53952:A0127 RS10235
gene id: 53952:A0127_RS10235
uniprot id: A0A142CXX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS06885
gene id: 53952:A0127_RS06885
uniprot id: A0A142CVV9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

53952:A0127 RS05985
gene id: 53952:A0127_RS05985
uniprot id: A0A142CVE7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

53952:A0127 RS07830
gene id: 53952:A0127_RS07830
uniprot id: A0A142CXP9
names: Similarity
messages: Belongs to the MEMO1 family.

53952:A0127 RS07565
gene id: 53952:A0127_RS07565
uniprot id: A0A142CW83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

53952:A0127 RS07545
gene id: 53952:A0127_RS07545
uniprot id: A0A142CW79
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

53952:A0127 RS04315
gene id: 53952:A0127_RS04315
uniprot id: A0A142CUJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

53952:A0127 RS08135
gene id: 53952:A0127_RS08135
uniprot id: A0A142CXQ0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

53952:A0127 RS04735
gene id: 53952:A0127_RS04735
uniprot id: A0A142CUR9
names: Similarity
messages: Belongs to the AOR/FOR family.

53952:A0127 RS04080
gene id: 53952:A0127_RS04080
uniprot id: A0A142CUF5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

53952:A0127 RS00450
gene id: 53952:A0127_RS00450
uniprot id: A0A142CSJ4
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

53952:A0127 RS08775
gene id: 53952:A0127_RS08775
uniprot id: A0A142CWU5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

53952:A0127 RS09275
gene id: 53952:A0127_RS09275
uniprot id: A0A142CX34
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

53952:A0127 RS03760
gene id: 53952:A0127_RS03760
uniprot id: A0A142CU97
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

53952:A0127 RS10240
gene id: 53952:A0127_RS10240
uniprot id: A0A142CXX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS09690
gene id: 53952:A0127_RS09690
uniprot id: A0A142CXA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

53952:A0127 RS06660
gene id: 53952:A0127_RS06660
uniprot id: A0A142CVS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

53952:A0127 RS01810
gene id: 53952:A0127_RS01810
uniprot id: A0A142CT92
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

53952:A0127 RS06360
gene id: 53952:A0127_RS06360
uniprot id: A0A142CVL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

53952:A0127 RS00265
gene id: 53952:A0127_RS00265
uniprot id: A0A142CSF8
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

53952:A0127 RS07615
gene id: 53952:A0127_RS07615
uniprot id: A0A142CW93
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

53952:A0127 RS07440
gene id: 53952:A0127_RS07440
uniprot id: A0A142CW60
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

53952:A0127 RS07895
gene id: 53952:A0127_RS07895
uniprot id: A0A142CWD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

53952:A0127 RS03205
gene id: 53952:A0127_RS03205
uniprot id: A0A142CTZ3
names: Similarity
messages: Belongs to the peptidase C56 family.

53952:A0127 RS07090
gene id: 53952:A0127_RS07090
uniprot id: A0A142CVZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

53952:A0127 RS04110
gene id: 53952:A0127_RS04110
uniprot id: A0A142CUG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

53952:A0127 RS06895
gene id: 53952:A0127_RS06895
uniprot id: A0A142CVW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

53952:A0127 RS08950
gene id: 53952:A0127_RS08950
uniprot id: A0A142CWX6
names: Similarity
messages: Belongs to the RuvB family.

53952:A0127 RS04465
gene id: 53952:A0127_RS04465
uniprot id: A0A142CUM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

53952:A0127 RS01315
gene id: 53952:A0127_RS01315
uniprot id: A0A142CT03
names: Similarity
messages: Belongs to the peptidase S9C family.

53952:A0127 RS04060
gene id: 53952:A0127_RS04060
uniprot id: A0A142CUF2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).