535712:A4Z71 RS00130
gene id: 535712:A4Z71_RS00130
uniprot id: A0A1D9DXE1
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS04300
gene id: 535712:A4Z71_RS04300
uniprot id: A0A1D9DZF1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

535712:A4Z71 RS00650
gene id: 535712:A4Z71_RS00650
uniprot id: A0A1D9DXM8
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

535712:A4Z71 RS00850
gene id: 535712:A4Z71_RS00850
uniprot id: A0A1D9DXR4
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

535712:A4Z71 RS03545
gene id: 535712:A4Z71_RS03545
uniprot id: A0A1D9DZ14
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02900
gene id: 535712:A4Z71_RS02900
uniprot id: A0A1D9DYR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

535712:A4Z71 RS03520
gene id: 535712:A4Z71_RS03520
uniprot id: A0A1D9DZ13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

535712:A4Z71 RS04660
gene id: 535712:A4Z71_RS04660
uniprot id: A0A1D9DZN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

535712:A4Z71 RS06040
gene id: 535712:A4Z71_RS06040
uniprot id: A0A1D9E0A5
names: Similarity
messages: Belongs to the pirin family.

535712:A4Z71 RS01120
gene id: 535712:A4Z71_RS01120
uniprot id: A0A1D9DXW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS01110
gene id: 535712:A4Z71_RS01110
uniprot id: A0A1D9DXX4
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS02925
gene id: 535712:A4Z71_RS02925
uniprot id: A0A1D9DYS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

535712:A4Z71 RS02730
gene id: 535712:A4Z71_RS02730
uniprot id: A0A1D9DYP2
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

535712:A4Z71 RS03490
gene id: 535712:A4Z71_RS03490
uniprot id: A0A1D9DZ12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

535712:A4Z71 RS05345
gene id: 535712:A4Z71_RS05345
uniprot id: A0A1D9E005
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

535712:A4Z71 RS02685
gene id: 535712:A4Z71_RS02685
uniprot id: A0A1D9E0X8
names: Similarity
messages: Belongs to the peptidase M1 family.

535712:A4Z71 RS00590
gene id: 535712:A4Z71_RS00590
uniprot id: A0A1D9DXM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

535712:A4Z71 RS00160
gene id: 535712:A4Z71_RS00160
uniprot id: A0A1D9DXE4
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

535712:A4Z71 RS03675
gene id: 535712:A4Z71_RS03675
uniprot id: A0A1D9DZ55
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

535712:A4Z71 RS01310
gene id: 535712:A4Z71_RS01310
uniprot id: A0A1D9E0U8
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05120
gene id: 535712:A4Z71_RS05120
uniprot id: A0A1D9DZV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

535712:A4Z71 RS01860
gene id: 535712:A4Z71_RS01860
uniprot id: A0A1D9DY88
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

535712:A4Z71 RS04285
gene id: 535712:A4Z71_RS04285
uniprot id: A0A1D9E103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

535712:A4Z71 RS05195
gene id: 535712:A4Z71_RS05195
uniprot id: A0A1D9E002
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS04955
gene id: 535712:A4Z71_RS04955
uniprot id: A0A1D9DZT9
names: Similarity
messages: Belongs to the DEAD box helicase family.

535712:A4Z71 RS04575
gene id: 535712:A4Z71_RS04575
uniprot id: A0A1D9DZP0
names: Similarity
messages: Belongs to the peptidase M16 family.

535712:A4Z71 RS02975
gene id: 535712:A4Z71_RS02975
uniprot id: A0A1D9DYU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

535712:A4Z71 RS00195
gene id: 535712:A4Z71_RS00195
uniprot id: A0A1D9DXF1
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS06800
gene id: 535712:A4Z71_RS06800
uniprot id: A0A1D9E0P7
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS02490
gene id: 535712:A4Z71_RS02490
uniprot id: A0A1D9DYK9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

535712:A4Z71 RS02930
gene id: 535712:A4Z71_RS02930
uniprot id: A0A1D9DYS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

535712:A4Z71 RS06915
gene id: 535712:A4Z71_RS06915
uniprot id: A0A1D9E0T4
names: Similarity
messages: Belongs to the thioredoxin family.

535712:A4Z71 RS03585
gene id: 535712:A4Z71_RS03585
uniprot id: A0A1D9DZ29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

535712:A4Z71 RS04825
gene id: 535712:A4Z71_RS04825
uniprot id: A0A1D9DZP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

535712:A4Z71 RS04400
gene id: 535712:A4Z71_RS04400
uniprot id: A0A1D9DZI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

535712:A4Z71 RS06515
gene id: 535712:A4Z71_RS06515
uniprot id: A0A1D9E0J7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

535712:A4Z71 RS01995
gene id: 535712:A4Z71_RS01995
uniprot id: A0A1D9DYB0
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

535712:A4Z71 RS01410
gene id: 535712:A4Z71_RS01410
uniprot id: A0A1D9DY13
names: Similarity
messages: Belongs to the peptidase S13 family.

535712:A4Z71 RS00855
gene id: 535712:A4Z71_RS00855
uniprot id: A0A1D9DXS0
names: Similarity
messages: Belongs to the glycosyl hydrolase.

535712:A4Z71 RS05585
gene id: 535712:A4Z71_RS05585
uniprot id: A0A1D9E055
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Homodimer.
messages: In the N-terminal section; belongs to the DHBP synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS06070
gene id: 535712:A4Z71_RS06070
uniprot id: A0A1D9E0E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

535712:A4Z71 RS00940
gene id: 535712:A4Z71_RS00940
uniprot id: A0A1D9DXS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

535712:A4Z71 RS05700
gene id: 535712:A4Z71_RS05700
uniprot id: A0A1D9E057
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

535712:A4Z71 RS01655
gene id: 535712:A4Z71_RS01655
uniprot id: A0A1D9DY62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

535712:A4Z71 RS04140
gene id: 535712:A4Z71_RS04140
uniprot id: A0A1D9DZC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

535712:A4Z71 RS06785
gene id: 535712:A4Z71_RS06785
uniprot id: A0A1D9E0Q2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02500
gene id: 535712:A4Z71_RS02500
uniprot id: A0A1D9DYI4
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

535712:A4Z71 RS04080
gene id: 535712:A4Z71_RS04080
uniprot id: A0A1D9DZC1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

535712:A4Z71 RS06380
gene id: 535712:A4Z71_RS06380
uniprot id: A0A1D9E0H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS04050
gene id: 535712:A4Z71_RS04050
uniprot id: A0A1D9DZC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

535712:A4Z71 RS01400
gene id: 535712:A4Z71_RS01400
uniprot id: A0A1D9DY24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

535712:A4Z71 RS01570
gene id: 535712:A4Z71_RS01570
uniprot id: A0A1D9DY56
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

535712:A4Z71 RS03095
gene id: 535712:A4Z71_RS03095
uniprot id: A0A1D9DYW3
names: Similarity
messages: Belongs to the thymidine kinase family.

535712:A4Z71 RS05060
gene id: 535712:A4Z71_RS05060
uniprot id: A0A1D9DZT8
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS04505
gene id: 535712:A4Z71_RS04505
uniprot id: A0A1D9DZK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

535712:A4Z71 RS01575
gene id: 535712:A4Z71_RS01575
uniprot id: A0A1D9DY39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

535712:A4Z71 RS05715
gene id: 535712:A4Z71_RS05715
uniprot id: A0A1D9E069
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

535712:A4Z71 RS01175
gene id: 535712:A4Z71_RS01175
uniprot id: A0A1D9DXW9
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02855
gene id: 535712:A4Z71_RS02855
uniprot id: A0A1D9DYP7
names: Similarity
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

535712:A4Z71 RS02820
gene id: 535712:A4Z71_RS02820
uniprot id: A0A1D9DYR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

535712:A4Z71 RS03415
gene id: 535712:A4Z71_RS03415
uniprot id: A0A1D9DYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

535712:A4Z71 RS01820
gene id: 535712:A4Z71_RS01820
uniprot id: A0A1D9DY71
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS04235
gene id: 535712:A4Z71_RS04235
uniprot id: A0A1D9DZF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

535712:A4Z71 RS04690
gene id: 535712:A4Z71_RS04690
uniprot id: A0A1D9DZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS02870
gene id: 535712:A4Z71_RS02870
uniprot id: A0A1D9DYQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

535712:A4Z71 RS04775
gene id: 535712:A4Z71_RS04775
uniprot id: A0A1D9DZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

535712:A4Z71 RS00015
gene id: 535712:A4Z71_RS00015
uniprot id: A0A1D9DX89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

535712:A4Z71 RS00230
gene id: 535712:A4Z71_RS00230
uniprot id: A0A1D9DXF0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05965
gene id: 535712:A4Z71_RS05965
uniprot id: A0A1D9E0C3
names: Similarity
messages: Belongs to the group II decarboxylase family.

535712:A4Z71 RS05720
gene id: 535712:A4Z71_RS05720
uniprot id: A0A1D9E059
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

535712:A4Z71 RS03330
gene id: 535712:A4Z71_RS03330
uniprot id: A0A1D9DYY6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

535712:A4Z71 RS06035
gene id: 535712:A4Z71_RS06035
uniprot id: A0A1D9E0C5
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS03005
gene id: 535712:A4Z71_RS03005
uniprot id: A0A1D9DYS7
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

535712:A4Z71 RS05165
gene id: 535712:A4Z71_RS05165
uniprot id: A0A1D9DZV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

535712:A4Z71 RS05570
gene id: 535712:A4Z71_RS05570
uniprot id: A0A1D9E032
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS04765
gene id: 535712:A4Z71_RS04765
uniprot id: A0A1D9DZQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

535712:A4Z71 RS01500
gene id: 535712:A4Z71_RS01500
uniprot id: A0A1D9DY29
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

535712:A4Z71 RS04855
gene id: 535712:A4Z71_RS04855
uniprot id: A0A1D9DZP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS02785
gene id: 535712:A4Z71_RS02785
uniprot id: A0A1D9DYN7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

535712:A4Z71 RS06055
gene id: 535712:A4Z71_RS06055
uniprot id: A0A1D9E0B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

535712:A4Z71 RS06685
gene id: 535712:A4Z71_RS06685
uniprot id: A0A1D9E0M7
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

535712:A4Z71 RS01750
gene id: 535712:A4Z71_RS01750
uniprot id: A0A1D9DY73
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

535712:A4Z71 RS05970
gene id: 535712:A4Z71_RS05970
uniprot id: A0A1D9E095
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

535712:A4Z71 RS04810
gene id: 535712:A4Z71_RS04810
uniprot id: A0A1D9DZQ2
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

535712:A4Z71 RS02745
gene id: 535712:A4Z71_RS02745
uniprot id: A0A1D9DYQ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

535712:A4Z71 RS03560
gene id: 535712:A4Z71_RS03560
uniprot id: A0A1D9DZ62
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02750
gene id: 535712:A4Z71_RS02750
uniprot id: A0A1D9DYL9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

535712:A4Z71 RS03615
gene id: 535712:A4Z71_RS03615
uniprot id: A0A1D9DZ69
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

535712:A4Z71 RS05845
gene id: 535712:A4Z71_RS05845
uniprot id: A0A1D9E0A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

535712:A4Z71 RS02160
gene id: 535712:A4Z71_RS02160
uniprot id: A0A1D9DYC2
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

535712:A4Z71 RS05590
gene id: 535712:A4Z71_RS05590
uniprot id: A0A1D9E018
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

535712:A4Z71 RS02340
gene id: 535712:A4Z71_RS02340
uniprot id: A0A1D9E0Y3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

535712:A4Z71 RS00010
gene id: 535712:A4Z71_RS00010
uniprot id: A0A1D9DX88
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS01275
gene id: 535712:A4Z71_RS01275
uniprot id: A0A1D9DXY9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

535712:A4Z71 RS03365
gene id: 535712:A4Z71_RS03365
uniprot id: A0A1D9DYZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS03800
gene id: 535712:A4Z71_RS03800
uniprot id: A0A1D9DZ67
names: Similarity
messages: Belongs to the DNA photolyase family.

535712:A4Z71 RS04880
gene id: 535712:A4Z71_RS04880
uniprot id: A0A1D9DZR3
names: Similarity
messages: Belongs to the peptidase S1C family.

535712:A4Z71 RS04680
gene id: 535712:A4Z71_RS04680
uniprot id: A0A1D9DZR5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS01675
gene id: 535712:A4Z71_RS01675
uniprot id: A0A1D9DY60
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

535712:A4Z71 RS06000
gene id: 535712:A4Z71_RS06000
uniprot id: A0A1D9E0A4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

535712:A4Z71 RS00625
gene id: 535712:A4Z71_RS00625
uniprot id: A0A1D9DXM3
names: Similarity
messages: Belongs to the peptidase C40 family.

535712:A4Z71 RS00585
gene id: 535712:A4Z71_RS00585
uniprot id: A0A1D9DXM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

535712:A4Z71 RS01030
gene id: 535712:A4Z71_RS01030
uniprot id: A0A1D9DXU8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

535712:A4Z71 RS06220
gene id: 535712:A4Z71_RS06220
uniprot id: A0A1D9E0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

535712:A4Z71 RS05290
gene id: 535712:A4Z71_RS05290
uniprot id: A0A1D9DZZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

535712:A4Z71 RS05670
gene id: 535712:A4Z71_RS05670
uniprot id: A0A1D9E047
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

535712:A4Z71 RS05260
gene id: 535712:A4Z71_RS05260
uniprot id: A0A1D9E011
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

535712:A4Z71 RS02355
gene id: 535712:A4Z71_RS02355
uniprot id: A0A1D9DYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

535712:A4Z71 RS02920
gene id: 535712:A4Z71_RS02920
uniprot id: A0A1D9DYS2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

535712:A4Z71 RS03735
gene id: 535712:A4Z71_RS03735
uniprot id: A0A1D9DZ65
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

535712:A4Z71 RS04290
gene id: 535712:A4Z71_RS04290
uniprot id: A0A1D9DZI8
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

535712:A4Z71 RS06830
gene id: 535712:A4Z71_RS06830
uniprot id: A0A1D9E0R7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

535712:A4Z71 RS05940
gene id: 535712:A4Z71_RS05940
uniprot id: A0A1D9E0B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

535712:A4Z71 RS03515
gene id: 535712:A4Z71_RS03515
uniprot id: A0A1D9DZ15
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS03535
gene id: 535712:A4Z71_RS03535
uniprot id: A0A1D9DZ32
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

535712:A4Z71 RS02105
gene id: 535712:A4Z71_RS02105
uniprot id: A0A1D9DYD5
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS07110
gene id: 535712:A4Z71_RS07110
uniprot id: A0A1D9DZG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

535712:A4Z71 RS04425
gene id: 535712:A4Z71_RS04425
uniprot id: A0A1D9DZI3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

535712:A4Z71 RS03845
gene id: 535712:A4Z71_RS03845
uniprot id: A0A1D9DZ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

535712:A4Z71 RS00095
gene id: 535712:A4Z71_RS00095
uniprot id: A0A1D9DXD5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

535712:A4Z71 RS04385
gene id: 535712:A4Z71_RS04385
uniprot id: A0A1D9DZH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

535712:A4Z71 RS05885
gene id: 535712:A4Z71_RS05885
uniprot id: A0A1D9E075
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

535712:A4Z71 RS05225
gene id: 535712:A4Z71_RS05225
uniprot id: A0A1D9DZX3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

535712:A4Z71 RS04375
gene id: 535712:A4Z71_RS04375
uniprot id: A0A1D9DZH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

535712:A4Z71 RS05660
gene id: 535712:A4Z71_RS05660
uniprot id: A0A1D9E036
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

535712:A4Z71 RS02875
gene id: 535712:A4Z71_RS02875
uniprot id: A0A1D9DYR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

535712:A4Z71 RS03035
gene id: 535712:A4Z71_RS03035
uniprot id: A0A1D9DYU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

535712:A4Z71 RS06575
gene id: 535712:A4Z71_RS06575
uniprot id: A0A1D9E0M5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

535712:A4Z71 RS02275
gene id: 535712:A4Z71_RS02275
uniprot id: A0A1D9DYG0
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

535712:A4Z71 RS02420
gene id: 535712:A4Z71_RS02420
uniprot id: A0A1D9DYH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

535712:A4Z71 RS04615
gene id: 535712:A4Z71_RS04615
uniprot id: A0A1D9DZK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

535712:A4Z71 RS06640
gene id: 535712:A4Z71_RS06640
uniprot id: A0A1D9E0L5
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

535712:A4Z71 RS06335
gene id: 535712:A4Z71_RS06335
uniprot id: A0A1D9E0G7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

535712:A4Z71 RS03105
gene id: 535712:A4Z71_RS03105
uniprot id: A0A1D9DYV5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

535712:A4Z71 RS00865
gene id: 535712:A4Z71_RS00865
uniprot id: A0A1D9DXR3
names: Similarity
messages: Belongs to the UPF0234 family.

535712:A4Z71 RS05160
gene id: 535712:A4Z71_RS05160
uniprot id: A0A1D9DZW2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS01085
gene id: 535712:A4Z71_RS01085
uniprot id: A0A1D9DXV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

535712:A4Z71 RS02380
gene id: 535712:A4Z71_RS02380
uniprot id: A0A1D9DYH2
names: Similarity
messages: Belongs to the UPF0102 family.

535712:A4Z71 RS00020
gene id: 535712:A4Z71_RS00020
uniprot id: A0A1D9DXC0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

535712:A4Z71 RS03730
gene id: 535712:A4Z71_RS03730
uniprot id: A0A1D9DZ90
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

535712:A4Z71 RS03410
gene id: 535712:A4Z71_RS03410
uniprot id: A0A1D9DYZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

535712:A4Z71 RS01165
gene id: 535712:A4Z71_RS01165
uniprot id: A0A1D9DXW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS06605
gene id: 535712:A4Z71_RS06605
uniprot id: A0A1D9E0K7
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS01840
gene id: 535712:A4Z71_RS01840
uniprot id: A0A1D9DY74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

535712:A4Z71 RS04900
gene id: 535712:A4Z71_RS04900
uniprot id: A0A1D9DZS8
names: Similarity
messages: Belongs to the peptidase S16 family.

535712:A4Z71 RS03045
gene id: 535712:A4Z71_RS03045
uniprot id: A0A1D9DYU4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

535712:A4Z71 RS01530
gene id: 535712:A4Z71_RS01530
uniprot id: A0A1D9DY31
names: Similarity
messages: Belongs to the Nudix hydrolase family.

535712:A4Z71 RS01920
gene id: 535712:A4Z71_RS01920
uniprot id: A0A1D9E0U7
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS05910
gene id: 535712:A4Z71_RS05910
uniprot id: A0A1D9E0C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

535712:A4Z71 RS00950
gene id: 535712:A4Z71_RS00950
uniprot id: A0A1D9DXT5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

535712:A4Z71 RS03220
gene id: 535712:A4Z71_RS03220
uniprot id: A0A1D9DYX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

535712:A4Z71 RS06360
gene id: 535712:A4Z71_RS06360
uniprot id: A0A1D9E0H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

535712:A4Z71 RS02415
gene id: 535712:A4Z71_RS02415
uniprot id: A0A1D9DYI3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05470
gene id: 535712:A4Z71_RS05470
uniprot id: A0A1D9E051
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

535712:A4Z71 RS04380
gene id: 535712:A4Z71_RS04380
uniprot id: A0A1D9DZH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

535712:A4Z71 RS04115
gene id: 535712:A4Z71_RS04115
uniprot id: A0A1D9DZF9
names: Similarity
messages: Belongs to the YggT family.

535712:A4Z71 RS06520
gene id: 535712:A4Z71_RS06520
uniprot id: A0A1D9E0L8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

535712:A4Z71 RS00235
gene id: 535712:A4Z71_RS00235
uniprot id: A0A1D9DXF9
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS01700
gene id: 535712:A4Z71_RS01700
uniprot id: A0A1D9DY61
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

535712:A4Z71 RS06375
gene id: 535712:A4Z71_RS06375
uniprot id: A0A1D9E0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS05020
gene id: 535712:A4Z71_RS05020
uniprot id: A0A1D9DZU8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

535712:A4Z71 RS00505
gene id: 535712:A4Z71_RS00505
uniprot id: A0A1D9DXL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

535712:A4Z71 RS04580
gene id: 535712:A4Z71_RS04580
uniprot id: A0A1D9E144
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

535712:A4Z71 RS05095
gene id: 535712:A4Z71_RS05095
uniprot id: A0A1D9DZU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

535712:A4Z71 RS02910
gene id: 535712:A4Z71_RS02910
uniprot id: A0A1D9DYS9
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS03170
gene id: 535712:A4Z71_RS03170
uniprot id: A0A1D9DYW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

535712:A4Z71 RS00880
gene id: 535712:A4Z71_RS00880
uniprot id: A0A1D9DXS5
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS03430
gene id: 535712:A4Z71_RS03430
uniprot id: A0A1D9DZ09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

535712:A4Z71 RS04335
gene id: 535712:A4Z71_RS04335
uniprot id: A0A1D9DZH4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

535712:A4Z71 RS06745
gene id: 535712:A4Z71_RS06745
uniprot id: A0A1D9E0N4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

535712:A4Z71 RS06865
gene id: 535712:A4Z71_RS06865
uniprot id: A0A1D9E0Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

535712:A4Z71 RS06110
gene id: 535712:A4Z71_RS06110
uniprot id: A0A1D9E0C7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

535712:A4Z71 RS05230
gene id: 535712:A4Z71_RS05230
uniprot id: A0A1D9DZW5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

535712:A4Z71 RS06670
gene id: 535712:A4Z71_RS06670
uniprot id: A0A1D9E0N1
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.

535712:A4Z71 RS05185
gene id: 535712:A4Z71_RS05185
uniprot id: A0A1D9DZV7
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

535712:A4Z71 RS02240
gene id: 535712:A4Z71_RS02240
uniprot id: A0A1D9DYG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

535712:A4Z71 RS00760
gene id: 535712:A4Z71_RS00760
uniprot id: A0A1D9E0T5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS03100
gene id: 535712:A4Z71_RS03100
uniprot id: A0A1D9DYV7
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

535712:A4Z71 RS02665
gene id: 535712:A4Z71_RS02665
uniprot id: A0A1D9DYK8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

535712:A4Z71 RS02325
gene id: 535712:A4Z71_RS02325
uniprot id: A0A1D9DYG2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

535712:A4Z71 RS05920
gene id: 535712:A4Z71_RS05920
uniprot id: A0A1D9E086
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

535712:A4Z71 RS01470
gene id: 535712:A4Z71_RS01470
uniprot id: A0A1D9DY19
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

535712:A4Z71 RS07025
gene id: 535712:A4Z71_RS07025
uniprot id: A0A1D9DZV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

535712:A4Z71 RS05500
gene id: 535712:A4Z71_RS05500
uniprot id: A0A1D9E013
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

535712:A4Z71 RS04550
gene id: 535712:A4Z71_RS04550
uniprot id: A0A1D9DZK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

535712:A4Z71 RS05730
gene id: 535712:A4Z71_RS05730
uniprot id: A0A1D9E084
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS05295
gene id: 535712:A4Z71_RS05295
uniprot id: A0A1D9DZY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

535712:A4Z71 RS05785
gene id: 535712:A4Z71_RS05785
uniprot id: A0A1D9E068
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

535712:A4Z71 RS01985
gene id: 535712:A4Z71_RS01985
uniprot id: A0A1D9E0V6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

535712:A4Z71 RS03240
gene id: 535712:A4Z71_RS03240
uniprot id: A0A1D9DYX8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

535712:A4Z71 RS00660
gene id: 535712:A4Z71_RS00660
uniprot id: A0A1D9DXM7
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

535712:A4Z71 RS04445
gene id: 535712:A4Z71_RS04445
uniprot id: A0A1D9DZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

535712:A4Z71 RS05840
gene id: 535712:A4Z71_RS05840
uniprot id: A0A1D9E081
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

535712:A4Z71 RS02940
gene id: 535712:A4Z71_RS02940
uniprot id: A0A1D9DYR6
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

535712:A4Z71 RS05790
gene id: 535712:A4Z71_RS05790
uniprot id: A0A1D9E070
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

535712:A4Z71 RS02995
gene id: 535712:A4Z71_RS02995
uniprot id: A0A1D9DYS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

535712:A4Z71 RS00945
gene id: 535712:A4Z71_RS00945
uniprot id: A0A1D9DXS2
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

535712:A4Z71 RS04780
gene id: 535712:A4Z71_RS04780
uniprot id: A0A1D9DZR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

535712:A4Z71 RS01150
gene id: 535712:A4Z71_RS01150
uniprot id: A0A1D9E0T8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

535712:A4Z71 RS04340
gene id: 535712:A4Z71_RS04340
uniprot id: A0A1D9DZJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS01020
gene id: 535712:A4Z71_RS01020
uniprot id: A0A1D9DXU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

535712:A4Z71 RS03745
gene id: 535712:A4Z71_RS03745
uniprot id: A0A1D9DZ61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

535712:A4Z71 RS04695
gene id: 535712:A4Z71_RS04695
uniprot id: A0A1D9DZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS00630
gene id: 535712:A4Z71_RS00630
uniprot id: A0A1D9DXN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

535712:A4Z71 RS06735
gene id: 535712:A4Z71_RS06735
uniprot id: A0A1D9E0N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

535712:A4Z71 RS01705
gene id: 535712:A4Z71_RS01705
uniprot id: A0A1D9DY57
names: Similarity
messages: Belongs to the peptidase C40 family.

535712:A4Z71 RS02060
gene id: 535712:A4Z71_RS02060
uniprot id: A0A1D9DYC6
names: Similarity
messages: Belongs to the TPP enzyme family.

535712:A4Z71 RS00805
gene id: 535712:A4Z71_RS00805
uniprot id: A0A1D9DXQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

535712:A4Z71 RS04820
gene id: 535712:A4Z71_RS04820
uniprot id: A0A1D9DZQ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02425
gene id: 535712:A4Z71_RS02425
uniprot id: A0A1D9DYJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

535712:A4Z71 RS03595
gene id: 535712:A4Z71_RS03595
uniprot id: A0A1D9DZ39
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

535712:A4Z71 RS04130
gene id: 535712:A4Z71_RS04130
uniprot id: A0A1D9DZD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

535712:A4Z71 RS04920
gene id: 535712:A4Z71_RS04920
uniprot id: A0A1D9DZQ3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

535712:A4Z71 RS02835
gene id: 535712:A4Z71_RS02835
uniprot id: A0A1D9DYQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

535712:A4Z71 RS02655
gene id: 535712:A4Z71_RS02655
uniprot id: A0A1D9DYL6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

535712:A4Z71 RS01865
gene id: 535712:A4Z71_RS01865
uniprot id: A0A1D9DY93
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

535712:A4Z71 RS04150
gene id: 535712:A4Z71_RS04150
uniprot id: A0A1D9DZC7
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS01925
gene id: 535712:A4Z71_RS01925
uniprot id: A0A1D9DYA3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS04185
gene id: 535712:A4Z71_RS04185
uniprot id: A0A1D9DZE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

535712:A4Z71 RS06015
gene id: 535712:A4Z71_RS06015
uniprot id: A0A1D9E0D3
names: Similarity
messages: Belongs to the cytochrome P450 family.

535712:A4Z71 RS05055
gene id: 535712:A4Z71_RS05055
uniprot id: A0A1D9DZU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

535712:A4Z71 RS04915
gene id: 535712:A4Z71_RS04915
uniprot id: A0A1D9DZS9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

535712:A4Z71 RS03405
gene id: 535712:A4Z71_RS03405
uniprot id: A0A1D9DZ10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

535712:A4Z71 RS06025
gene id: 535712:A4Z71_RS06025
uniprot id: A0A1D9E0A7
names: Similarity
messages: Belongs to the glutamine synthetase family.

535712:A4Z71 RS00425
gene id: 535712:A4Z71_RS00425
uniprot id: A0A1D9DXJ7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

535712:A4Z71 RS05015
gene id: 535712:A4Z71_RS05015
uniprot id: A0A1D9DZX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS04245
gene id: 535712:A4Z71_RS04245
uniprot id: A0A1D9DZF2
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

535712:A4Z71 RS05950
gene id: 535712:A4Z71_RS05950
uniprot id: A0A1D9E098
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

535712:A4Z71 RS04870
gene id: 535712:A4Z71_RS04870
uniprot id: A0A1D9DZQ5
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

535712:A4Z71 RS02695
gene id: 535712:A4Z71_RS02695
uniprot id: A0A1D9DYN5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

535712:A4Z71 RS00555
gene id: 535712:A4Z71_RS00555
uniprot id: A0A1D9DXL0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

535712:A4Z71 RS06920
gene id: 535712:A4Z71_RS06920
uniprot id: A0A1D9E0R5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

535712:A4Z71 RS03525
gene id: 535712:A4Z71_RS03525
uniprot id: A0A1D9DZ17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

535712:A4Z71 RS01285
gene id: 535712:A4Z71_RS01285
uniprot id: A0A1D9DXZ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS06680
gene id: 535712:A4Z71_RS06680
uniprot id: A0A1D9E0P5
names: Similarity
messages: Belongs to the peptidase M13 family.

535712:A4Z71 RS06395
gene id: 535712:A4Z71_RS06395
uniprot id: A0A1D9E131
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS04005
gene id: 535712:A4Z71_RS04005
uniprot id: A0A1D9DZB5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

535712:A4Z71 RS03325
gene id: 535712:A4Z71_RS03325
uniprot id: A0A1D9DZ00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

535712:A4Z71 RS03705
gene id: 535712:A4Z71_RS03705
uniprot id: A0A1D9DZ45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

535712:A4Z71 RS04190
gene id: 535712:A4Z71_RS04190
uniprot id: A0A1D9DZE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

535712:A4Z71 RS05900
gene id: 535712:A4Z71_RS05900
uniprot id: A0A1D9E090
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

535712:A4Z71 RS03785
gene id: 535712:A4Z71_RS03785
uniprot id: A0A1D9DZ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

535712:A4Z71 RS02220
gene id: 535712:A4Z71_RS02220
uniprot id: A0A1D9DYE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

535712:A4Z71 RS03760
gene id: 535712:A4Z71_RS03760
uniprot id: A0A1D9DZ70
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

535712:A4Z71 RS03575
gene id: 535712:A4Z71_RS03575
uniprot id: A0A1D9DZ26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

535712:A4Z71 RS00845
gene id: 535712:A4Z71_RS00845
uniprot id: A0A1D9DXR2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

535712:A4Z71 RS05665
gene id: 535712:A4Z71_RS05665
uniprot id: A0A1D9E058
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

535712:A4Z71 RS03140
gene id: 535712:A4Z71_RS03140
uniprot id: A0A1D9DYW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

535712:A4Z71 RS05830
gene id: 535712:A4Z71_RS05830
uniprot id: A0A1D9E088
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

535712:A4Z71 RS02595
gene id: 535712:A4Z71_RS02595
uniprot id: A0A1D9DYM0
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

535712:A4Z71 RS02660
gene id: 535712:A4Z71_RS02660
uniprot id: A0A1D9DYP0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

535712:A4Z71 RS06345
gene id: 535712:A4Z71_RS06345
uniprot id: A0A1D9E0L3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

535712:A4Z71 RS05805
gene id: 535712:A4Z71_RS05805
uniprot id: A0A1D9E094
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

535712:A4Z71 RS00225
gene id: 535712:A4Z71_RS00225
uniprot id: A0A1D9DXF4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

535712:A4Z71 RS06535
gene id: 535712:A4Z71_RS06535
uniprot id: A0A1D9E0L6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

535712:A4Z71 RS00535
gene id: 535712:A4Z71_RS00535
uniprot id: A0A1D9DXL5
names: Similarity
messages: Belongs to the GARS family.

535712:A4Z71 RS06525
gene id: 535712:A4Z71_RS06525
uniprot id: A0A1D9E0P3
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

535712:A4Z71 RS03875
gene id: 535712:A4Z71_RS03875
uniprot id: A0A1D9DZ93
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS03965
gene id: 535712:A4Z71_RS03965
uniprot id: A0A1D9DZ95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

535712:A4Z71 RS03425
gene id: 535712:A4Z71_RS03425
uniprot id: A0A1D9DZ03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

535712:A4Z71 RS03715
gene id: 535712:A4Z71_RS03715
uniprot id: A0A1D9DZ44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

535712:A4Z71 RS04525
gene id: 535712:A4Z71_RS04525
uniprot id: A0A1D9DZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

535712:A4Z71 RS01780
gene id: 535712:A4Z71_RS01780
uniprot id: A0A1D9DY64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

535712:A4Z71 RS00790
gene id: 535712:A4Z71_RS00790
uniprot id: A0A1D9DXP8
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

535712:A4Z71 RS04755
gene id: 535712:A4Z71_RS04755
uniprot id: A0A1D9DZP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

535712:A4Z71 RS03890
gene id: 535712:A4Z71_RS03890
uniprot id: A0A1D9DZ91
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

535712:A4Z71 RS03775
gene id: 535712:A4Z71_RS03775
uniprot id: A0A1D9DZ72
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05030
gene id: 535712:A4Z71_RS05030
uniprot id: A0A1D9DZS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

535712:A4Z71 RS03010
gene id: 535712:A4Z71_RS03010
uniprot id: A0A1D9DYU5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

535712:A4Z71 RS00105
gene id: 535712:A4Z71_RS00105
uniprot id: A0A1D9DXD2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

535712:A4Z71 RS05115
gene id: 535712:A4Z71_RS05115
uniprot id: A0A1D9DZV6
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

535712:A4Z71 RS04390
gene id: 535712:A4Z71_RS04390
uniprot id: A0A1D9DZG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

535712:A4Z71 RS04020
gene id: 535712:A4Z71_RS04020
uniprot id: A0A1D9DZA7
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

535712:A4Z71 RS02700
gene id: 535712:A4Z71_RS02700
uniprot id: A0A1D9DYM8
names: Similarity
messages: Belongs to the FPG family.

535712:A4Z71 RS00320
gene id: 535712:A4Z71_RS00320
uniprot id: A0A1D9DXH8
names: Similarity
messages: Belongs to the hyi family.

535712:A4Z71 RS01940
gene id: 535712:A4Z71_RS01940
uniprot id: A0A1D9E0W1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

535712:A4Z71 RS02620
gene id: 535712:A4Z71_RS02620
uniprot id: A0A1D9DYN3
names: Similarity
messages: Belongs to the group II decarboxylase family.

535712:A4Z71 RS01015
gene id: 535712:A4Z71_RS01015
uniprot id: A0A1D9DXU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

535712:A4Z71 RS05645
gene id: 535712:A4Z71_RS05645
uniprot id: A0A1D9E031
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

535712:A4Z71 RS00715
gene id: 535712:A4Z71_RS00715
uniprot id: A0A1D9E0T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

535712:A4Z71 RS00350
gene id: 535712:A4Z71_RS00350
uniprot id: A0A1D9DXI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS03505
gene id: 535712:A4Z71_RS03505
uniprot id: A0A1D9DZ52
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

535712:A4Z71 RS03810
gene id: 535712:A4Z71_RS03810
uniprot id: A0A1D9DZ79
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

535712:A4Z71 RS04395
gene id: 535712:A4Z71_RS04395
uniprot id: A0A1D9DZH2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

535712:A4Z71 RS06405
gene id: 535712:A4Z71_RS06405
uniprot id: A0A1D9E0M3
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

535712:A4Z71 RS02980
gene id: 535712:A4Z71_RS02980
uniprot id: A0A1D9DYT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

535712:A4Z71 RS02075
gene id: 535712:A4Z71_RS02075
uniprot id: A0A1D9DYD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

535712:A4Z71 RS01460
gene id: 535712:A4Z71_RS01460
uniprot id: A0A1D9DY23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

535712:A4Z71 RS05895
gene id: 535712:A4Z71_RS05895
uniprot id: A0A1D9E091
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

535712:A4Z71 RS00140
gene id: 535712:A4Z71_RS00140
uniprot id: A0A1D9DXE3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05045
gene id: 535712:A4Z71_RS05045
uniprot id: A0A1D9DZT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS00890
gene id: 535712:A4Z71_RS00890
uniprot id: A0A1D9DXR7
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS04585
gene id: 535712:A4Z71_RS04585
uniprot id: A0A1D9DZM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

535712:A4Z71 RS03225
gene id: 535712:A4Z71_RS03225
uniprot id: A0A1D9DYX7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

535712:A4Z71 RS03600
gene id: 535712:A4Z71_RS03600
uniprot id: A0A1D9DZ28
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

535712:A4Z71 RS01880
gene id: 535712:A4Z71_RS01880
uniprot id: A0A1D9E0V1
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

535712:A4Z71 RS02370
gene id: 535712:A4Z71_RS02370
uniprot id: A0A1D9DYG6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

535712:A4Z71 RS06560
gene id: 535712:A4Z71_RS06560
uniprot id: A0A1D9E0L2
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

535712:A4Z71 RS03485
gene id: 535712:A4Z71_RS03485
uniprot id: A0A1D9DZ20
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

535712:A4Z71 RS04200
gene id: 535712:A4Z71_RS04200
uniprot id: A0A1D9DZD4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

535712:A4Z71 RS03750
gene id: 535712:A4Z71_RS03750
uniprot id: A0A1D9DZ57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

535712:A4Z71 RS03565
gene id: 535712:A4Z71_RS03565
uniprot id: A0A1D9DZ36
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

535712:A4Z71 RS01970
gene id: 535712:A4Z71_RS01970
uniprot id: A0A1D9DYB5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

535712:A4Z71 RS01365
gene id: 535712:A4Z71_RS01365
uniprot id: A0A1D9DY04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

535712:A4Z71 RS06330
gene id: 535712:A4Z71_RS06330
uniprot id: A0A1D9E0G8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05640
gene id: 535712:A4Z71_RS05640
uniprot id: A0A1D9E065
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS01090
gene id: 535712:A4Z71_RS01090
uniprot id: A0A1D9E0V5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

535712:A4Z71 RS01895
gene id: 535712:A4Z71_RS01895
uniprot id: A0A1D9DYA0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS02120
gene id: 535712:A4Z71_RS02120
uniprot id: A0A1D9DYD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

535712:A4Z71 RS02285
gene id: 535712:A4Z71_RS02285
uniprot id: A0A1D9DYG3
names: Similarity
messages: Belongs to the citrate synthase family.

535712:A4Z71 RS04120
gene id: 535712:A4Z71_RS04120
uniprot id: A0A1D9DZE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

535712:A4Z71 RS01830
gene id: 535712:A4Z71_RS01830
uniprot id: A0A1D9DY82
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS03000
gene id: 535712:A4Z71_RS03000
uniprot id: A0A1D9DYT9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

535712:A4Z71 RS06620
gene id: 535712:A4Z71_RS06620
uniprot id: A0A1D9E0M2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

535712:A4Z71 RS02585
gene id: 535712:A4Z71_RS02585
uniprot id: A0A1D9DYL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

535712:A4Z71 RS04665
gene id: 535712:A4Z71_RS04665
uniprot id: A0A1D9DZL7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

535712:A4Z71 RS04160
gene id: 535712:A4Z71_RS04160
uniprot id: A0A1D9DZE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS01205
gene id: 535712:A4Z71_RS01205
uniprot id: A0A1D9DXX5
names: Subcellular Location Annotation
messages: Cell membrane

535712:A4Z71 RS00090
gene id: 535712:A4Z71_RS00090
uniprot id: A0A1D9DXD3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

535712:A4Z71 RS01900
gene id: 535712:A4Z71_RS01900
uniprot id: A0A1D9DY85
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

535712:A4Z71 RS03835
gene id: 535712:A4Z71_RS03835
uniprot id: A0A1D9DZ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

535712:A4Z71 RS01805
gene id: 535712:A4Z71_RS01805
uniprot id: A0A1D9DY86
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

535712:A4Z71 RS03620
gene id: 535712:A4Z71_RS03620
uniprot id: A0A1D9DZ46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

535712:A4Z71 RS01425
gene id: 535712:A4Z71_RS01425
uniprot id: A0A1D9DY22
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

535712:A4Z71 RS00025
gene id: 535712:A4Z71_RS00025
uniprot id: A0A1D9DX87
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

535712:A4Z71 RS03710
gene id: 535712:A4Z71_RS03710
uniprot id: A0A1D9DZ58
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

535712:A4Z71 RS02310
gene id: 535712:A4Z71_RS02310
uniprot id: A0A1D9DYF8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

535712:A4Z71 RS04735
gene id: 535712:A4Z71_RS04735
uniprot id: A0A1D9DZS5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

535712:A4Z71 RS02680
gene id: 535712:A4Z71_RS02680
uniprot id: A0A1D9DYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

535712:A4Z71 RS04010
gene id: 535712:A4Z71_RS04010
uniprot id: A0A1D9DZA3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS03090
gene id: 535712:A4Z71_RS03090
uniprot id: A0A1D9DYV0
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

535712:A4Z71 RS01890
gene id: 535712:A4Z71_RS01890
uniprot id: A0A1D9DY89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

535712:A4Z71 RS04170
gene id: 535712:A4Z71_RS04170
uniprot id: A0A1D9DZE9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS04630
gene id: 535712:A4Z71_RS04630
uniprot id: A0A1D9DZQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

535712:A4Z71 RS00825
gene id: 535712:A4Z71_RS00825
uniprot id: A0A1D9DXR5
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS02540
gene id: 535712:A4Z71_RS02540
uniprot id: A0A1D9DYL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS04485
gene id: 535712:A4Z71_RS04485
uniprot id: A0A1D9DZJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02300
gene id: 535712:A4Z71_RS02300
uniprot id: A0A1D9DYG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

535712:A4Z71 RS03990
gene id: 535712:A4Z71_RS03990
uniprot id: A0A1D9E107
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

535712:A4Z71 RS03420
gene id: 535712:A4Z71_RS03420
uniprot id: A0A1D9DYZ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

535712:A4Z71 RS03390
gene id: 535712:A4Z71_RS03390
uniprot id: A0A1D9E0Y0
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS05685
gene id: 535712:A4Z71_RS05685
uniprot id: A0A1D9E089
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

535712:A4Z71 RS01955
gene id: 535712:A4Z71_RS01955
uniprot id: A0A1D9DYB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

535712:A4Z71 RS05410
gene id: 535712:A4Z71_RS05410
uniprot id: A0A1D9E025
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

535712:A4Z71 RS01905
gene id: 535712:A4Z71_RS01905
uniprot id: A0A1D9DYA1
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

535712:A4Z71 RS06050
gene id: 535712:A4Z71_RS06050
uniprot id: A0A1D9E0C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

535712:A4Z71 RS04985
gene id: 535712:A4Z71_RS04985
uniprot id: A0A1D9DZS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

535712:A4Z71 RS00155
gene id: 535712:A4Z71_RS00155
uniprot id: A0A1D9DXE5
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS01445
gene id: 535712:A4Z71_RS01445
uniprot id: A0A1D9DY20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

535712:A4Z71 RS02205
gene id: 535712:A4Z71_RS02205
uniprot id: A0A1D9E0X2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

535712:A4Z71 RS02810
gene id: 535712:A4Z71_RS02810
uniprot id: A0A1D9DYN1
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

535712:A4Z71 RS06710
gene id: 535712:A4Z71_RS06710
uniprot id: A0A1D9E0N0
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS03805
gene id: 535712:A4Z71_RS03805
uniprot id: A0A1D9DZ66
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS03285
gene id: 535712:A4Z71_RS03285
uniprot id: A0A1D9DYY0
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

535712:A4Z71 RS05575
gene id: 535712:A4Z71_RS05575
uniprot id: A0A1D9E056
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

535712:A4Z71 RS02110
gene id: 535712:A4Z71_RS02110
uniprot id: A0A1D9DYE7
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS01155
gene id: 535712:A4Z71_RS01155
uniprot id: A0A1D9DXW6
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS01550
gene id: 535712:A4Z71_RS01550
uniprot id: A0A1D9DY38
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.
messages: Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.
messages: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02315
gene id: 535712:A4Z71_RS02315
uniprot id: A0A1D9DYE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

535712:A4Z71 RS05945
gene id: 535712:A4Z71_RS05945
uniprot id: A0A1D9E097
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

535712:A4Z71 RS07095
gene id: 535712:A4Z71_RS07095
uniprot id: A0A1D9E0H5
names: Similarity
messages: Belongs to the peptidase S8 family.

535712:A4Z71 RS02725
gene id: 535712:A4Z71_RS02725
uniprot id: A0A1D9DYM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

535712:A4Z71 RS03350
gene id: 535712:A4Z71_RS03350
uniprot id: A0A1D9DYZ4
names: Similarity
messages: Belongs to the SufE family.

535712:A4Z71 RS05460
gene id: 535712:A4Z71_RS05460
uniprot id: A0A1D9E009
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

535712:A4Z71 RS01965
gene id: 535712:A4Z71_RS01965
uniprot id: A0A1D9DY98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

535712:A4Z71 RS05705
gene id: 535712:A4Z71_RS05705
uniprot id: A0A1D9E063
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS03795
gene id: 535712:A4Z71_RS03795
uniprot id: A0A1D9DZ68
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

535712:A4Z71 RS02080
gene id: 535712:A4Z71_RS02080
uniprot id: A0A1D9DYB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

535712:A4Z71 RS04455
gene id: 535712:A4Z71_RS04455
uniprot id: A0A1D9DZJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

535712:A4Z71 RS05850
gene id: 535712:A4Z71_RS05850
uniprot id: A0A1D9E0B9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

535712:A4Z71 RS06045
gene id: 535712:A4Z71_RS06045
uniprot id: A0A1D9E0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

535712:A4Z71 RS05325
gene id: 535712:A4Z71_RS05325
uniprot id: A0A1D9E160
names: Similarity
messages: Belongs to the phosphohexose mutase family.

535712:A4Z71 RS03790
gene id: 535712:A4Z71_RS03790
uniprot id: A0A1D9DZ73
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

535712:A4Z71 RS03125
gene id: 535712:A4Z71_RS03125
uniprot id: A0A1D9E0X5
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

535712:A4Z71 RS04815
gene id: 535712:A4Z71_RS04815
uniprot id: A0A1D9DZP5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

535712:A4Z71 RS01495
gene id: 535712:A4Z71_RS01495
uniprot id: A0A1D9DY16
names: Similarity
messages: Belongs to the PrpD family.

535712:A4Z71 RS02215
gene id: 535712:A4Z71_RS02215
uniprot id: A0A1D9DYE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

535712:A4Z71 RS05925
gene id: 535712:A4Z71_RS05925
uniprot id: A0A1D9E099
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

535712:A4Z71 RS04410
gene id: 535712:A4Z71_RS04410
uniprot id: A0A1D9DZJ1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

535712:A4Z71 RS03765
gene id: 535712:A4Z71_RS03765
uniprot id: A0A1D9DZ54
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

535712:A4Z71 RS01660
gene id: 535712:A4Z71_RS01660
uniprot id: A0A1D9DY54
names: Similarity
messages: Belongs to the WXG100 family.

535712:A4Z71 RS05745
gene id: 535712:A4Z71_RS05745
uniprot id: A0A1D9E082
names: Similarity
messages: Belongs to the leucine-binding protein family.

535712:A4Z71 RS05800
gene id: 535712:A4Z71_RS05800
uniprot id: A0A1D9E0B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

535712:A4Z71 RS00065
gene id: 535712:A4Z71_RS00065
uniprot id: A0A1D9DXD8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

535712:A4Z71 RS04450
gene id: 535712:A4Z71_RS04450
uniprot id: A0A1D9DZI0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

535712:A4Z71 RS02515
gene id: 535712:A4Z71_RS02515
uniprot id: A0A1D9DYK4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

535712:A4Z71 RS05935
gene id: 535712:A4Z71_RS05935
uniprot id: A0A1D9E085
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

535712:A4Z71 RS04110
gene id: 535712:A4Z71_RS04110
uniprot id: A0A1D9DZD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

535712:A4Z71 RS04345
gene id: 535712:A4Z71_RS04345
uniprot id: A0A1D9DZI2
names: Similarity
messages: Belongs to the TlyA family.

535712:A4Z71 RS03470
gene id: 535712:A4Z71_RS03470
uniprot id: A0A1D9DZ02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

535712:A4Z71 RS00250
gene id: 535712:A4Z71_RS00250
uniprot id: A0A1D9DXG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

535712:A4Z71 RS00370
gene id: 535712:A4Z71_RS00370
uniprot id: A0A1D9DXI5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

535712:A4Z71 RS02125
gene id: 535712:A4Z71_RS02125
uniprot id: A0A1D9DYD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

535712:A4Z71 RS05960
gene id: 535712:A4Z71_RS05960
uniprot id: A0A1D9E0D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

535712:A4Z71 RS03120
gene id: 535712:A4Z71_RS03120
uniprot id: A0A1D9DYV6
names: Similarity
messages: Belongs to the CdaR family.

535712:A4Z71 RS05035
gene id: 535712:A4Z71_RS05035
uniprot id: A0A1D9DZT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

535712:A4Z71 RS02410
gene id: 535712:A4Z71_RS02410
uniprot id: A0A1D9DYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

535712:A4Z71 RS04760
gene id: 535712:A4Z71_RS04760
uniprot id: A0A1D9DZN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

535712:A4Z71 RS02390
gene id: 535712:A4Z71_RS02390
uniprot id: A0A1D9DYG7
names: Similarity
messages: Belongs to the DprA/Smf family.

535712:A4Z71 RS04225
gene id: 535712:A4Z71_RS04225
uniprot id: A0A1D9DZE2
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

535712:A4Z71 RS01315
gene id: 535712:A4Z71_RS01315
uniprot id: A0A1D9DXZ7
names: Similarity
messages: Belongs to the GSP E family.

535712:A4Z71 RS01280
gene id: 535712:A4Z71_RS01280
uniprot id: A0A1D9DY07
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

535712:A4Z71 RS00840
gene id: 535712:A4Z71_RS00840
uniprot id: A0A1D9DXR0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

535712:A4Z71 RS03435
gene id: 535712:A4Z71_RS03435
uniprot id: A0A1D9DZ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

535712:A4Z71 RS04650
gene id: 535712:A4Z71_RS04650
uniprot id: A0A1D9DZM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

535712:A4Z71 RS03195
gene id: 535712:A4Z71_RS03195
uniprot id: A0A1D9DYV9
names: Similarity
messages: Belongs to the glutamine synthetase family.

535712:A4Z71 RS00820
gene id: 535712:A4Z71_RS00820
uniprot id: A0A1D9DXQ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

535712:A4Z71 RS03145
gene id: 535712:A4Z71_RS03145
uniprot id: A0A1D9DYU3
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

535712:A4Z71 RS06460
gene id: 535712:A4Z71_RS06460
uniprot id: A0A1D9E0N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane

535712:A4Z71 RS04165
gene id: 535712:A4Z71_RS04165
uniprot id: A0A1D9DZG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

535712:A4Z71 RS02250
gene id: 535712:A4Z71_RS02250
uniprot id: A0A1D9DYF6
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS02280
gene id: 535712:A4Z71_RS02280
uniprot id: A0A1D9DYE0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

535712:A4Z71 RS03310
gene id: 535712:A4Z71_RS03310
uniprot id: A0A1D9DYX4
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

535712:A4Z71 RS00385
gene id: 535712:A4Z71_RS00385
uniprot id: A0A1D9DXI3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

535712:A4Z71 RS04155
gene id: 535712:A4Z71_RS04155
uniprot id: A0A1D9DZC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

535712:A4Z71 RS04800
gene id: 535712:A4Z71_RS04800
uniprot id: A0A1D9DZP6
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS00420
gene id: 535712:A4Z71_RS00420
uniprot id: A0A1D9DXJ4
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

535712:A4Z71 RS04600
gene id: 535712:A4Z71_RS04600
uniprot id: A0A1D9DZL3
names: Similarity
messages: Belongs to the ribF family.

535712:A4Z71 RS02295
gene id: 535712:A4Z71_RS02295
uniprot id: A0A1D9E0X3
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

535712:A4Z71 RS03445
gene id: 535712:A4Z71_RS03445
uniprot id: A0A1D9DZ16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

535712:A4Z71 RS04935
gene id: 535712:A4Z71_RS04935
uniprot id: A0A1D9DZR4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

535712:A4Z71 RS01765
gene id: 535712:A4Z71_RS01765
uniprot id: A0A1D9DY83
names: Similarity
messages: Belongs to the YciI family.

535712:A4Z71 RS01510
gene id: 535712:A4Z71_RS01510
uniprot id: A0A1D9DY45
names: Similarity
messages: Belongs to the FGGY kinase family.

535712:A4Z71 RS00040
gene id: 535712:A4Z71_RS00040
uniprot id: A0A1D9DXB0
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

535712:A4Z71 RS04645
gene id: 535712:A4Z71_RS04645
uniprot id: A0A1D9DZL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

535712:A4Z71 RS05870
gene id: 535712:A4Z71_RS05870
uniprot id: A0A1D9E087
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

535712:A4Z71 RS06840
gene id: 535712:A4Z71_RS06840
uniprot id: A0A1D9E0P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

535712:A4Z71 RS01095
gene id: 535712:A4Z71_RS01095
uniprot id: A0A1D9DXV6
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

535712:A4Z71 RS05880
gene id: 535712:A4Z71_RS05880
uniprot id: A0A1D9E093
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

535712:A4Z71 RS06775
gene id: 535712:A4Z71_RS06775
uniprot id: A0A1D9E133
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

535712:A4Z71 RS02360
gene id: 535712:A4Z71_RS02360
uniprot id: A0A1D9DYH8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

535712:A4Z71 RS03650
gene id: 535712:A4Z71_RS03650
uniprot id: A0A1D9DZ35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

535712:A4Z71 RS01975
gene id: 535712:A4Z71_RS01975
uniprot id: A0A1D9DY92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS03190
gene id: 535712:A4Z71_RS03190
uniprot id: A0A1D9E0Y2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS04475
gene id: 535712:A4Z71_RS04475
uniprot id: A0A1D9DZI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

535712:A4Z71 RS04770
gene id: 535712:A4Z71_RS04770
uniprot id: A0A1D9DZP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

535712:A4Z71 RS02175
gene id: 535712:A4Z71_RS02175
uniprot id: A0A1D9DYF7
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS02580
gene id: 535712:A4Z71_RS02580
uniprot id: A0A1D9DYL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homotetramer.

535712:A4Z71 RS01535
gene id: 535712:A4Z71_RS01535
uniprot id: A0A1D9DY26
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

535712:A4Z71 RS05915
gene id: 535712:A4Z71_RS05915
uniprot id: A0A1D9E0B3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

535712:A4Z71 RS06870
gene id: 535712:A4Z71_RS06870
uniprot id: A0A1D9E0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

535712:A4Z71 RS02830
gene id: 535712:A4Z71_RS02830
uniprot id: A0A1D9DYQ6
names: Similarity
messages: Belongs to the UPF0235 family.

535712:A4Z71 RS06250
gene id: 535712:A4Z71_RS06250
uniprot id: A0A1D9E0H2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

535712:A4Z71 RS05510
gene id: 535712:A4Z71_RS05510
uniprot id: A0A1D9E017
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS01935
gene id: 535712:A4Z71_RS01935
uniprot id: A0A1D9DYA6
names: Similarity
messages: Belongs to the peptidase A24 family.

535712:A4Z71 RS04840
gene id: 535712:A4Z71_RS04840
uniprot id: A0A1D9DZU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

535712:A4Z71 RS05360
gene id: 535712:A4Z71_RS05360
uniprot id: A0A1D9E016
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS04715
gene id: 535712:A4Z71_RS04715
uniprot id: A0A1D9DZN2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

535712:A4Z71 RS06845
gene id: 535712:A4Z71_RS06845
uniprot id: A0A1D9E0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

535712:A4Z71 RS01385
gene id: 535712:A4Z71_RS01385
uniprot id: A0A1D9DY10
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS01755
gene id: 535712:A4Z71_RS01755
uniprot id: A0A1D9DY76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

535712:A4Z71 RS06780
gene id: 535712:A4Z71_RS06780
uniprot id: A0A1D9E0Q1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

535712:A4Z71 RS03235
gene id: 535712:A4Z71_RS03235
uniprot id: A0A1D9DYW1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

535712:A4Z71 RS00275
gene id: 535712:A4Z71_RS00275
uniprot id: A0A1D9DXG7
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS04470
gene id: 535712:A4Z71_RS04470
uniprot id: A0A1D9DZH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

535712:A4Z71 RS01600
gene id: 535712:A4Z71_RS01600
uniprot id: A0A1D9DY51
names: Caution
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
messages: In the C-terminal section; belongs to the IspF family.
messages: In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS00450
gene id: 535712:A4Z71_RS00450
uniprot id: A0A1D9DXJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS04100
gene id: 535712:A4Z71_RS04100
uniprot id: A0A1D9DZB7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

535712:A4Z71 RS02990
gene id: 535712:A4Z71_RS02990
uniprot id: A0A1D9DYT4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

535712:A4Z71 RS05505
gene id: 535712:A4Z71_RS05505
uniprot id: A0A1D9E027
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

535712:A4Z71 RS03440
gene id: 535712:A4Z71_RS03440
uniprot id: A0A1D9DYZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

535712:A4Z71 RS05860
gene id: 535712:A4Z71_RS05860
uniprot id: A0A1D9E076
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

535712:A4Z71 RS01795
gene id: 535712:A4Z71_RS01795
uniprot id: A0A1D9E0W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

535712:A4Z71 RS00605
gene id: 535712:A4Z71_RS00605
uniprot id: A0A1D9DXM0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

535712:A4Z71 RS00955
gene id: 535712:A4Z71_RS00955
uniprot id: A0A1D9DXU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

535712:A4Z71 RS06320
gene id: 535712:A4Z71_RS06320
uniprot id: A0A1D9E0G6
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

535712:A4Z71 RS01785
gene id: 535712:A4Z71_RS01785
uniprot id: A0A1D9DY78
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

535712:A4Z71 RS06855
gene id: 535712:A4Z71_RS06855
uniprot id: A0A1D9E0S3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

535712:A4Z71 RS02320
gene id: 535712:A4Z71_RS02320
uniprot id: A0A1D9DYG8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

535712:A4Z71 RS06590
gene id: 535712:A4Z71_RS06590
uniprot id: A0A1D9E0M6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

535712:A4Z71 RS04405
gene id: 535712:A4Z71_RS04405
uniprot id: A0A1D9DZL0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

535712:A4Z71 RS05395
gene id: 535712:A4Z71_RS05395
uniprot id: A0A1D9E010
names: Similarity
messages: Belongs to the ABC transporter superfamily.

535712:A4Z71 RS00795
gene id: 535712:A4Z71_RS00795
uniprot id: A0A1D9DXQ4
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS00815
gene id: 535712:A4Z71_RS00815
uniprot id: A0A1D9DXQ1
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS03205
gene id: 535712:A4Z71_RS03205
uniprot id: A0A1D9DYV4
names: Similarity
messages: Belongs to the glutamine synthetase family.

535712:A4Z71 RS00640
gene id: 535712:A4Z71_RS00640
uniprot id: A0A1D9DXN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

535712:A4Z71 RS03665
gene id: 535712:A4Z71_RS03665
uniprot id: A0A1D9DZ53
names: Similarity
messages: Belongs to the glutamate synthase family.

535712:A4Z71 RS04865
gene id: 535712:A4Z71_RS04865
uniprot id: A0A1D9DZR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

535712:A4Z71 RS04625
gene id: 535712:A4Z71_RS04625
uniprot id: A0A1D9DZM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

535712:A4Z71 RS02405
gene id: 535712:A4Z71_RS02405
uniprot id: A0A1D9DYI6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

535712:A4Z71 RS04490
gene id: 535712:A4Z71_RS04490
uniprot id: A0A1D9DZJ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

535712:A4Z71 RS03530
gene id: 535712:A4Z71_RS03530
uniprot id: A0A1D9DZ22
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

535712:A4Z71 RS02005
gene id: 535712:A4Z71_RS02005
uniprot id: A0A1D9DYB3
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

535712:A4Z71 RS03395
gene id: 535712:A4Z71_RS03395
uniprot id: A0A1D9DZ07
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05955
gene id: 535712:A4Z71_RS05955
uniprot id: A0A1D9E0B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

535712:A4Z71 RS05050
gene id: 535712:A4Z71_RS05050
uniprot id: A0A1D9DZU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

535712:A4Z71 RS02965
gene id: 535712:A4Z71_RS02965
uniprot id: A0A1D9DYR4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

535712:A4Z71 RS05480
gene id: 535712:A4Z71_RS05480
uniprot id: A0A1D9E000
names: Similarity
messages: Belongs to the phosphohexose mutase family.

535712:A4Z71 RS03740
gene id: 535712:A4Z71_RS03740
uniprot id: A0A1D9DZ60
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

535712:A4Z71 RS02645
gene id: 535712:A4Z71_RS02645
uniprot id: A0A1D9DYL1
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

535712:A4Z71 RS05780
gene id: 535712:A4Z71_RS05780
uniprot id: A0A1D9E135
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

535712:A4Z71 RS00710
gene id: 535712:A4Z71_RS00710
uniprot id: A0A1D9DXN8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

535712:A4Z71 RS05605
gene id: 535712:A4Z71_RS05605
uniprot id: A0A1D9E029
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Membrane

535712:A4Z71 RS01080
gene id: 535712:A4Z71_RS01080
uniprot id: A0A1D9DXW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

535712:A4Z71 RS02575
gene id: 535712:A4Z71_RS02575
uniprot id: A0A1D9DYL5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

535712:A4Z71 RS01990
gene id: 535712:A4Z71_RS01990
uniprot id: A0A1D9DYC7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

535712:A4Z71 RS06510
gene id: 535712:A4Z71_RS06510
uniprot id: A0A1D9E0K2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05690
gene id: 535712:A4Z71_RS05690
uniprot id: A0A1D9E074
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

535712:A4Z71 RS02780
gene id: 535712:A4Z71_RS02780
uniprot id: A0A1D9DYP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

535712:A4Z71 RS05350
gene id: 535712:A4Z71_RS05350
uniprot id: A0A1D9DZZ4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

535712:A4Z71 RS03115
gene id: 535712:A4Z71_RS03115
uniprot id: A0A1D9DYU2
names: Similarity
messages: Belongs to the fabD family.

535712:A4Z71 RS04830
gene id: 535712:A4Z71_RS04830
uniprot id: A0A1D9DZQ0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

535712:A4Z71 RS05905
gene id: 535712:A4Z71_RS05905
uniprot id: A0A1D9E0A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

535712:A4Z71 RS01605
gene id: 535712:A4Z71_RS01605
uniprot id: A0A1D9DY47
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

535712:A4Z71 RS02365
gene id: 535712:A4Z71_RS02365
uniprot id: A0A1D9DYH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

535712:A4Z71 RS00080
gene id: 535712:A4Z71_RS00080
uniprot id: A0A1D9DXD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS04570
gene id: 535712:A4Z71_RS04570
uniprot id: A0A1D9DZL8
names: Similarity
messages: Belongs to the DapB family.

535712:A4Z71 RS03510
gene id: 535712:A4Z71_RS03510
uniprot id: A0A1D9DZ27
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

535712:A4Z71 RS05680
gene id: 535712:A4Z71_RS05680
uniprot id: A0A1D9E073
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

535712:A4Z71 RS05890
gene id: 535712:A4Z71_RS05890
uniprot id: A0A1D9E0A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

535712:A4Z71 RS05175
gene id: 535712:A4Z71_RS05175
uniprot id: A0A1D9DZW1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS04420
gene id: 535712:A4Z71_RS04420
uniprot id: A0A1D9DZH6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

535712:A4Z71 RS02790
gene id: 535712:A4Z71_RS02790
uniprot id: A0A1D9DYN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

535712:A4Z71 RS02520
gene id: 535712:A4Z71_RS02520
uniprot id: A0A1D9DYK6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

535712:A4Z71 RS01125
gene id: 535712:A4Z71_RS01125
uniprot id: A0A1D9DXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS05385
gene id: 535712:A4Z71_RS05385
uniprot id: A0A1D9E004
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

535712:A4Z71 RS03780
gene id: 535712:A4Z71_RS03780
uniprot id: A0A1D9DZ99
names: Similarity
messages: Belongs to the GPI family.

535712:A4Z71 RS05415
gene id: 535712:A4Z71_RS05415
uniprot id: A0A1D9E042
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05475
gene id: 535712:A4Z71_RS05475
uniprot id: A0A1D9E034
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.

535712:A4Z71 RS03450
gene id: 535712:A4Z71_RS03450
uniprot id: A0A1D9DZ37
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

535712:A4Z71 RS06105
gene id: 535712:A4Z71_RS06105
uniprot id: A0A1D9E0D2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

535712:A4Z71 RS05930
gene id: 535712:A4Z71_RS05930
uniprot id: A0A1D9E0B1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

535712:A4Z71 RS04330
gene id: 535712:A4Z71_RS04330
uniprot id: A0A1D9DZF6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02345
gene id: 535712:A4Z71_RS02345
uniprot id: A0A1D9DYH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

535712:A4Z71 RS06860
gene id: 535712:A4Z71_RS06860
uniprot id: A0A1D9E0Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

535712:A4Z71 RS06825
gene id: 535712:A4Z71_RS06825
uniprot id: A0A1D9E0U3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

535712:A4Z71 RS01730
gene id: 535712:A4Z71_RS01730
uniprot id: A0A1D9DY55
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

535712:A4Z71 RS02485
gene id: 535712:A4Z71_RS02485
uniprot id: A0A1D9DYI8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

535712:A4Z71 RS00925
gene id: 535712:A4Z71_RS00925
uniprot id: A0A1D9DXS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

535712:A4Z71 RS02795
gene id: 535712:A4Z71_RS02795
uniprot id: A0A1D9DYQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS04835
gene id: 535712:A4Z71_RS04835
uniprot id: A0A1D9DZS1
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

535712:A4Z71 RS01835
gene id: 535712:A4Z71_RS01835
uniprot id: A0A1D9DY95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

535712:A4Z71 RS00460
gene id: 535712:A4Z71_RS00460
uniprot id: A0A1D9DXK7
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

535712:A4Z71 RS04460
gene id: 535712:A4Z71_RS04460
uniprot id: A0A1D9DZM2
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

535712:A4Z71 RS04215
gene id: 535712:A4Z71_RS04215
uniprot id: A0A1D9DZH9
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

535712:A4Z71 RS02800
gene id: 535712:A4Z71_RS02800
uniprot id: A0A1D9DYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

535712:A4Z71 RS06100
gene id: 535712:A4Z71_RS06100
uniprot id: A0A1D9E0E1
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS04725
gene id: 535712:A4Z71_RS04725
uniprot id: A0A1D9E111
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

535712:A4Z71 RS02945
gene id: 535712:A4Z71_RS02945
uniprot id: A0A1D9DYR5
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

535712:A4Z71 RS00860
gene id: 535712:A4Z71_RS00860
uniprot id: A0A1D9DXR8
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS05550
gene id: 535712:A4Z71_RS05550
uniprot id: A0A1D9E033
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

535712:A4Z71 RS04965
gene id: 535712:A4Z71_RS04965
uniprot id: A0A1D9DZT7
names: Similarity
messages: Belongs to the peptidase M24B family.

535712:A4Z71 RS05810
gene id: 535712:A4Z71_RS05810
uniprot id: A0A1D9E062
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

535712:A4Z71 RS03495
gene id: 535712:A4Z71_RS03495
uniprot id: A0A1D9DZ06
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

535712:A4Z71 RS05655
gene id: 535712:A4Z71_RS05655
uniprot id: A0A1D9E053
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

535712:A4Z71 RS04640
gene id: 535712:A4Z71_RS04640
uniprot id: A0A1D9DZK4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

535712:A4Z71 RS03385
gene id: 535712:A4Z71_RS03385
uniprot id: A0A1D9E0Z0
names: Similarity
messages: Belongs to the MQO family.

535712:A4Z71 RS07030
gene id: 535712:A4Z71_RS07030
uniprot id: A0A1D9DZW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

535712:A4Z71 RS03925
gene id: 535712:A4Z71_RS03925
uniprot id: A0A1D9DZ84
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS04075
gene id: 535712:A4Z71_RS04075
uniprot id: A0A1D9E0Y9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

535712:A4Z71 RS05755
gene id: 535712:A4Z71_RS05755
uniprot id: A0A1D9E067
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

535712:A4Z71 RS02135
gene id: 535712:A4Z71_RS02135
uniprot id: A0A1D9DYE3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

535712:A4Z71 RS01825
gene id: 535712:A4Z71_RS01825
uniprot id: A0A1D9DY91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

535712:A4Z71 RS03720
gene id: 535712:A4Z71_RS03720
uniprot id: A0A1D9DZ48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

535712:A4Z71 RS03180
gene id: 535712:A4Z71_RS03180
uniprot id: A0A1D9DYV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

535712:A4Z71 RS00785
gene id: 535712:A4Z71_RS00785
uniprot id: A0A1D9DXP6
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS06935
gene id: 535712:A4Z71_RS06935
uniprot id: A0A1D9E0U2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

535712:A4Z71 RS04845
gene id: 535712:A4Z71_RS04845
uniprot id: A0A1D9DZS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

535712:A4Z71 RS00110
gene id: 535712:A4Z71_RS00110
uniprot id: A0A1D9DXD0
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS06390
gene id: 535712:A4Z71_RS06390
uniprot id: A0A1D9E0H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS03970
gene id: 535712:A4Z71_RS03970
uniprot id: A0A1D9DZB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

535712:A4Z71 RS02070
gene id: 535712:A4Z71_RS02070
uniprot id: A0A1D9DYB1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

535712:A4Z71 RS03540
gene id: 535712:A4Z71_RS03540
uniprot id: A0A1D9DZ21
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

535712:A4Z71 RS02530
gene id: 535712:A4Z71_RS02530
uniprot id: A0A1D9DYK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

535712:A4Z71 RS00100
gene id: 535712:A4Z71_RS00100
uniprot id: A0A1D9DXD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

535712:A4Z71 RS01650
gene id: 535712:A4Z71_RS01650
uniprot id: A0A1D9DY44
names: Subcellular Location Annotation
messages: Cytoplasm

535712:A4Z71 RS03825
gene id: 535712:A4Z71_RS03825
uniprot id: A0A1D9DZ81
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

535712:A4Z71 RS02385
gene id: 535712:A4Z71_RS02385
uniprot id: A0A1D9DYI1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

535712:A4Z71 RS04990
gene id: 535712:A4Z71_RS04990
uniprot id: A0A1D9DZU0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

535712:A4Z71 RS03245
gene id: 535712:A4Z71_RS03245
uniprot id: A0A1D9DYW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

535712:A4Z71 RS00150
gene id: 535712:A4Z71_RS00150
uniprot id: A0A1D9DXE7
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

535712:A4Z71 RS03695
gene id: 535712:A4Z71_RS03695
uniprot id: A0A1D9DZ50
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

535712:A4Z71 RS01345
gene id: 535712:A4Z71_RS01345
uniprot id: A0A1D9DY03
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

535712:A4Z71 RS05405
gene id: 535712:A4Z71_RS05405
uniprot id: A0A1D9DZZ8
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

535712:A4Z71 RS05515
gene id: 535712:A4Z71_RS05515
uniprot id: A0A1D9E020
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS03870
gene id: 535712:A4Z71_RS03870
uniprot id: A0A1D9DZ83
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

535712:A4Z71 RS02130
gene id: 535712:A4Z71_RS02130
uniprot id: A0A1D9DYC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

535712:A4Z71 RS05750
gene id: 535712:A4Z71_RS05750
uniprot id: A0A1D9E050
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

535712:A4Z71 RS04145
gene id: 535712:A4Z71_RS04145
uniprot id: A0A1D9DZD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS00560
gene id: 535712:A4Z71_RS00560
uniprot id: A0A1D9DXL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

535712:A4Z71 RS01690
gene id: 535712:A4Z71_RS01690
uniprot id: A0A1D9E0Z6
names: Subcellular Location Annotation
messages: Cytoplasm

535712:A4Z71 RS04125
gene id: 535712:A4Z71_RS04125
uniprot id: A0A1D9DZC3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

535712:A4Z71 RS03755
gene id: 535712:A4Z71_RS03755
uniprot id: A0A1D9DZ56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

535712:A4Z71 RS06895
gene id: 535712:A4Z71_RS06895
uniprot id: A0A1D9E0R0
names: Similarity
messages: Belongs to the ParB family.

535712:A4Z71 RS04700
gene id: 535712:A4Z71_RS04700
uniprot id: A0A1D9DZN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

535712:A4Z71 RS05190
gene id: 535712:A4Z71_RS05190
uniprot id: A0A1D9DZX8
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS05835
gene id: 535712:A4Z71_RS05835
uniprot id: A0A1D9E079
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

535712:A4Z71 RS04270
gene id: 535712:A4Z71_RS04270
uniprot id: A0A1D9DZE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

535712:A4Z71 RS05170
gene id: 535712:A4Z71_RS05170
uniprot id: A0A1D9DZW9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

535712:A4Z71 RS02350
gene id: 535712:A4Z71_RS02350
uniprot id: A0A1D9DYH4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

535712:A4Z71 RS00260
gene id: 535712:A4Z71_RS00260
uniprot id: A0A1D9DXG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

535712:A4Z71 RS01100
gene id: 535712:A4Z71_RS01100
uniprot id: A0A1D9DXV2
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

535712:A4Z71 RS02015
gene id: 535712:A4Z71_RS02015
uniprot id: A0A1D9DYC1
names: Similarity
messages: Belongs to the AHA1 family.

535712:A4Z71 RS03070
gene id: 535712:A4Z71_RS03070
uniprot id: A0A1D9DYT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

535712:A4Z71 RS00510
gene id: 535712:A4Z71_RS00510
uniprot id: A0A1D9DXL6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

535712:A4Z71 RS01260
gene id: 535712:A4Z71_RS01260
uniprot id: A0A1D9DXY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

535712:A4Z71 RS01340
gene id: 535712:A4Z71_RS01340
uniprot id: A0A1D9DY01
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

535712:A4Z71 RS03110
gene id: 535712:A4Z71_RS03110
uniprot id: A0A1D9DYV3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

535712:A4Z71 RS05400
gene id: 535712:A4Z71_RS05400
uniprot id: A0A1D9DZZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS00310
gene id: 535712:A4Z71_RS00310
uniprot id: A0A1D9DXH2
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

535712:A4Z71 RS02170
gene id: 535712:A4Z71_RS02170
uniprot id: A0A1D9DYE5
names: Similarity
messages: Belongs to the GSP E family.

535712:A4Z71 RS05815
gene id: 535712:A4Z71_RS05815
uniprot id: A0A1D9E077
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

535712:A4Z71 RS00200
gene id: 535712:A4Z71_RS00200
uniprot id: A0A1D9DXF2
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus membrane

535712:A4Z71 RS05630
gene id: 535712:A4Z71_RS05630
uniprot id: A0A1D9E064
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS02510
gene id: 535712:A4Z71_RS02510
uniprot id: A0A1D9DYL2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

535712:A4Z71 RS03610
gene id: 535712:A4Z71_RS03610
uniprot id: A0A1D9DZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

535712:A4Z71 RS06850
gene id: 535712:A4Z71_RS06850
uniprot id: A0A1D9E0R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

535712:A4Z71 RS06495
gene id: 535712:A4Z71_RS06495
uniprot id: A0A1D9E0J9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS06060
gene id: 535712:A4Z71_RS06060
uniprot id: A0A1D9E0D4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

535712:A4Z71 RS06655
gene id: 535712:A4Z71_RS06655
uniprot id: A0A1D9E0N6
names: Subcellular Location Annotation
messages: Membrane

535712:A4Z71 RS04685
gene id: 535712:A4Z71_RS04685
uniprot id: A0A1D9DZN8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

535712:A4Z71 RS04860
gene id: 535712:A4Z71_RS04860
uniprot id: A0A1D9DZQ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

535712:A4Z71 RS02150
gene id: 535712:A4Z71_RS02150
uniprot id: A0A1D9DYC9
names: Similarity
messages: Belongs to the peptidase S8 family.

535712:A4Z71 RS05855
gene id: 535712:A4Z71_RS05855
uniprot id: A0A1D9E0A3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

535712:A4Z71 RS03655
gene id: 535712:A4Z71_RS03655
uniprot id: A0A1D9DZ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

535712:A4Z71 RS05150
gene id: 535712:A4Z71_RS05150
uniprot id: A0A1D9DZU1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

535712:A4Z71 RS05825
gene id: 535712:A4Z71_RS05825
uniprot id: A0A1D9E066
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

535712:A4Z71 RS04930
gene id: 535712:A4Z71_RS04930
uniprot id: A0A1D9DZR8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

535712:A4Z71 RS05320
gene id: 535712:A4Z71_RS05320
uniprot id: A0A1D9DZX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

535712:A4Z71 RS04785
gene id: 535712:A4Z71_RS04785
uniprot id: A0A1D9DZT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

535712:A4Z71 RS02395
gene id: 535712:A4Z71_RS02395
uniprot id: A0A1D9DYI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

535712:A4Z71 RS02765
gene id: 535712:A4Z71_RS02765
uniprot id: A0A1D9DYP6
names: Similarity
messages: Belongs to the NDK family.

535712:A4Z71 RS06180
gene id: 535712:A4Z71_RS06180
uniprot id: A0A1D9E0I0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

535712:A4Z71 RS05795
gene id: 535712:A4Z71_RS05795
uniprot id: A0A1D9E092
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

535712:A4Z71 RS05560
gene id: 535712:A4Z71_RS05560
uniprot id: A0A1D9E038
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

535712:A4Z71 RS04015
gene id: 535712:A4Z71_RS04015
uniprot id: A0A1D9DZB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

535712:A4Z71 RS02985
gene id: 535712:A4Z71_RS02985
uniprot id: A0A1D9DYT8
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

535712:A4Z71 RS03580
gene id: 535712:A4Z71_RS03580
uniprot id: A0A1D9DZ25
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

535712:A4Z71 RS05635
gene id: 535712:A4Z71_RS05635
uniprot id: A0A1D9E080
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.