529709:PYCH RS09210
gene id: 529709:PYCH_RS09210
uniprot id: F8AID2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

529709:PYCH RS01325
gene id: 529709:PYCH_RS01325
uniprot id: F8AGK5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

529709:PYCH RS02205
gene id: 529709:PYCH_RS02205
uniprot id: F8AHE2
names: Similarity
messages: Belongs to the MoaD family.

529709:PYCH RS02730
gene id: 529709:PYCH_RS02730
uniprot id: F8AHV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS00745
gene id: 529709:PYCH_RS00745
uniprot id: F8AIP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

529709:PYCH RS06380
gene id: 529709:PYCH_RS06380
uniprot id: F8AFK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

529709:PYCH RS06100
gene id: 529709:PYCH_RS06100
uniprot id: F8AF91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

529709:PYCH RS08135
gene id: 529709:PYCH_RS08135
uniprot id: F8AH98
names: Similarity
messages: Belongs to the UPF0146 family.

529709:PYCH RS02435
gene id: 529709:PYCH_RS02435
uniprot id: F8AHI0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

529709:PYCH RS01220
gene id: 529709:PYCH_RS01220
uniprot id: F8AGB6
names: Similarity
messages: Belongs to the enolase family.

529709:PYCH RS04065
gene id: 529709:PYCH_RS04065
uniprot id: F8AJ76
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

529709:PYCH RS02770
gene id: 529709:PYCH_RS02770
uniprot id: F8AHW6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

529709:PYCH RS02070
gene id: 529709:PYCH_RS02070
uniprot id: F8AHB6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

529709:PYCH RS01310
gene id: 529709:PYCH_RS01310
uniprot id: F8AGK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

529709:PYCH RS06815
gene id: 529709:PYCH_RS06815
uniprot id: F8AG03
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS08095
gene id: 529709:PYCH_RS08095
uniprot id: F8AH91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

529709:PYCH RS01120
gene id: 529709:PYCH_RS01120
uniprot id: F8AIQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

529709:PYCH RS09345
gene id: 529709:PYCH_RS09345
uniprot id: F8AIF5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

529709:PYCH RS04840
gene id: 529709:PYCH_RS04840
uniprot id: F8AEJ5
names: Similarity
messages: Belongs to the UPF0145 family.

529709:PYCH RS05985
gene id: 529709:PYCH_RS05985
uniprot id: F8AF70
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

529709:PYCH RS06820
gene id: 529709:PYCH_RS06820
uniprot id: F8AG04
names: Subunit
messages: Homodimer.

529709:PYCH RS00655
gene id: 529709:PYCH_RS00655
uniprot id: F8AFU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

529709:PYCH RS01680
gene id: 529709:PYCH_RS01680
uniprot id: F8AGY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

529709:PYCH RS09240
gene id: 529709:PYCH_RS09240
uniprot id: F8AID9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

529709:PYCH RS02930
gene id: 529709:PYCH_RS02930
uniprot id: F8AI58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

529709:PYCH RS08100
gene id: 529709:PYCH_RS08100
uniprot id: F8AH92
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS01410
gene id: 529709:PYCH_RS01410
uniprot id: F8AGM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

529709:PYCH RS03340
gene id: 529709:PYCH_RS03340
uniprot id: F8AIK4
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

529709:PYCH RS00560
gene id: 529709:PYCH_RS00560
uniprot id: F8AFS7
names: Similarity
messages: Belongs to the RuvB family.

529709:PYCH RS02495
gene id: 529709:PYCH_RS02495
uniprot id: F8AHR2
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

529709:PYCH RS00620
gene id: 529709:PYCH_RS00620
uniprot id: F8AFT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

529709:PYCH RS06500
gene id: 529709:PYCH_RS06500
uniprot id: F8AFM5
names: Similarity
messages: Belongs to the UPF0147 family.

529709:PYCH RS07185
gene id: 529709:PYCH_RS07185
uniprot id: F8AGE2
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

529709:PYCH RS01115
gene id: 529709:PYCH_RS01115
uniprot id: F8AGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

529709:PYCH RS04705
gene id: 529709:PYCH_RS04705
uniprot id: F8AEC8
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

529709:PYCH RS06800
gene id: 529709:PYCH_RS06800
uniprot id: F8AG00
names: Similarity
messages: Belongs to the UPF0107 family.

529709:PYCH RS04725
gene id: 529709:PYCH_RS04725
uniprot id: F8AED2
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

529709:PYCH RS08835
gene id: 529709:PYCH_RS08835
uniprot id: F8AI06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

529709:PYCH RS00675
gene id: 529709:PYCH_RS00675
uniprot id: F8AFV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

529709:PYCH RS05020
gene id: 529709:PYCH_RS05020
uniprot id: F8AEN3
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS00990
gene id: 529709:PYCH_RS00990
uniprot id: F8AG80
names: Similarity
messages: Belongs to the UPF0292 family.

529709:PYCH RS07875
gene id: 529709:PYCH_RS07875
uniprot id: F8AH46
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

529709:PYCH RS07585
gene id: 529709:PYCH_RS07585
uniprot id: F8AGS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

529709:PYCH RS02410
gene id: 529709:PYCH_RS02410
uniprot id: F8AHH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Cytoplasm
messages: Homohexamer.

529709:PYCH RS04790
gene id: 529709:PYCH_RS04790
uniprot id: F8AEI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

529709:PYCH RS03175
gene id: 529709:PYCH_RS03175
uniprot id: F8AI97
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

529709:PYCH RS01075
gene id: 529709:PYCH_RS01075
uniprot id: F8AG96
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

529709:PYCH RS06245
gene id: 529709:PYCH_RS06245
uniprot id: F8AFB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

529709:PYCH RS08315
gene id: 529709:PYCH_RS08315
uniprot id: F8AHI6
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

529709:PYCH RS02625
gene id: 529709:PYCH_RS02625
uniprot id: F8AHT9
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

529709:PYCH RS06505
gene id: 529709:PYCH_RS06505
uniprot id: F8AFM6
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS04310
gene id: 529709:PYCH_RS04310
uniprot id: F8AJB8
names: Subcellular Location Annotation
messages: Cell membrane

529709:PYCH RS05690
gene id: 529709:PYCH_RS05690
uniprot id: F8AF09
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

529709:PYCH RS07345
gene id: 529709:PYCH_RS07345
uniprot id: F8AGG7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS08650
gene id: 529709:PYCH_RS08650
uniprot id: F8AHP7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

529709:PYCH RS08985
gene id: 529709:PYCH_RS08985
uniprot id: F8AI24
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

529709:PYCH RS01865
gene id: 529709:PYCH_RS01865
uniprot id: F8AH18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

529709:PYCH RS00835
gene id: 529709:PYCH_RS00835
uniprot id: F8AFX7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

529709:PYCH RS05115
gene id: 529709:PYCH_RS05115
uniprot id: F8AEP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

529709:PYCH RS07515
gene id: 529709:PYCH_RS07515
uniprot id: F8AGR5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

529709:PYCH RS04765
gene id: 529709:PYCH_RS04765
uniprot id: F8AEH9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

529709:PYCH RS08130
gene id: 529709:PYCH_RS08130
uniprot id: F8AH97
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

529709:PYCH RS00520
gene id: 529709:PYCH_RS00520
uniprot id: F8AFR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

529709:PYCH RS01180
gene id: 529709:PYCH_RS01180
uniprot id: F8AIQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

529709:PYCH RS04050
gene id: 529709:PYCH_RS04050
uniprot id: F8AJ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

529709:PYCH RS05110
gene id: 529709:PYCH_RS05110
uniprot id: F8AEP8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

529709:PYCH RS08995
gene id: 529709:PYCH_RS08995
uniprot id: F8AEG6
names: Function
messages: Probably involved in the biogenesis of the ribosome.

529709:PYCH RS09165
gene id: 529709:PYCH_RS09165
uniprot id: F8AIC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

529709:PYCH RS05515
gene id: 529709:PYCH_RS05515
uniprot id: F8AEX4
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS09280
gene id: 529709:PYCH_RS09280
uniprot id: F8AEH0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

529709:PYCH RS02830
gene id: 529709:PYCH_RS02830
uniprot id: F8AI39
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

529709:PYCH RS02880
gene id: 529709:PYCH_RS02880
uniprot id: F8AI49
names: Similarity
messages: Belongs to the MCM family.

529709:PYCH RS02595
gene id: 529709:PYCH_RS02595
uniprot id: F8AHT3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

529709:PYCH RS00780
gene id: 529709:PYCH_RS00780
uniprot id: F8AFW8
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS05350
gene id: 529709:PYCH_RS05350
uniprot id: F8AEU3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

529709:PYCH RS03605
gene id: 529709:PYCH_RS03605
uniprot id: F8AIU8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

529709:PYCH RS01215
gene id: 529709:PYCH_RS01215
uniprot id: F8AIQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

529709:PYCH RS05610
gene id: 529709:PYCH_RS05610
uniprot id: F8AEZ2
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS00400
gene id: 529709:PYCH_RS00400
uniprot id: F8AFI3
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS04105
gene id: 529709:PYCH_RS04105
uniprot id: F8AJ83
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

529709:PYCH RS05650
gene id: 529709:PYCH_RS05650
uniprot id: F8AF00
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

529709:PYCH RS05595
gene id: 529709:PYCH_RS05595
uniprot id: F8AEY9
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS02140
gene id: 529709:PYCH_RS02140
uniprot id: F8AHD0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS01540
gene id: 529709:PYCH_RS01540
uniprot id: F8AGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

529709:PYCH RS01460
gene id: 529709:PYCH_RS01460
uniprot id: F8AGN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

529709:PYCH RS02055
gene id: 529709:PYCH_RS02055
uniprot id: F8AIR9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS09380
gene id: 529709:PYCH_RS09380
uniprot id: F8AEH7
names: Similarity
messages: Belongs to the peptidase U62 family.

529709:PYCH RS04665
gene id: 529709:PYCH_RS04665
uniprot id: F8AJ41
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

529709:PYCH RS01175
gene id: 529709:PYCH_RS01175
uniprot id: F8AGB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS01490
gene id: 529709:PYCH_RS01490
uniprot id: F8AGN5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

529709:PYCH RS07060
gene id: 529709:PYCH_RS07060
uniprot id: F8AG50
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

529709:PYCH RS09180
gene id: 529709:PYCH_RS09180
uniprot id: F8AIC6
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

529709:PYCH RS01635
gene id: 529709:PYCH_RS01635
uniprot id: F8AGQ8
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS05715
gene id: 529709:PYCH_RS05715
uniprot id: F8AF12
names: Similarity
messages: Belongs to the UPF0212 family.

529709:PYCH RS00715
gene id: 529709:PYCH_RS00715
uniprot id: F8AFV7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

529709:PYCH RS03735
gene id: 529709:PYCH_RS03735
uniprot id: F8AIX3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

529709:PYCH RS07840
gene id: 529709:PYCH_RS07840
uniprot id: F8AGX4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

529709:PYCH RS01590
gene id: 529709:PYCH_RS01590
uniprot id: F8AGQ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

529709:PYCH RS01430
gene id: 529709:PYCH_RS01430
uniprot id: F8AGM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

529709:PYCH RS05520
gene id: 529709:PYCH_RS05520
uniprot id: F8AEX5
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS01525
gene id: 529709:PYCH_RS01525
uniprot id: F8AGP2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS00670
gene id: 529709:PYCH_RS00670
uniprot id: F8AFU9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

529709:PYCH RS00310
gene id: 529709:PYCH_RS00310
uniprot id: F8AIG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

529709:PYCH RS07815
gene id: 529709:PYCH_RS07815
uniprot id: F8AJH8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

529709:PYCH RS06570
gene id: 529709:PYCH_RS06570
uniprot id: F8AFN6
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

529709:PYCH RS03255
gene id: 529709:PYCH_RS03255
uniprot id: F8AII7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

529709:PYCH RS04910
gene id: 529709:PYCH_RS04910
uniprot id: F8AEK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

529709:PYCH RS05620
gene id: 529709:PYCH_RS05620
uniprot id: F8AEZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS00070
gene id: 529709:PYCH_RS00070
uniprot id: F8AF52
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

529709:PYCH RS05435
gene id: 529709:PYCH_RS05435
uniprot id: F8AEW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS00950
gene id: 529709:PYCH_RS00950
uniprot id: F8AG71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

529709:PYCH RS00225
gene id: 529709:PYCH_RS00225
uniprot id: F8AFF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

529709:PYCH RS03135
gene id: 529709:PYCH_RS03135
uniprot id: F8AI91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS00235
gene id: 529709:PYCH_RS00235
uniprot id: F8AFF9
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS08890
gene id: 529709:PYCH_RS08890
uniprot id: F8AI12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

529709:PYCH RS01085
gene id: 529709:PYCH_RS01085
uniprot id: F8AG98
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

529709:PYCH RS03035
gene id: 529709:PYCH_RS03035
uniprot id: F8AI77
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

529709:PYCH RS00305
gene id: 529709:PYCH_RS00305
uniprot id: F8AFH1
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

529709:PYCH RS07375
gene id: 529709:PYCH_RS07375
uniprot id: F8AGH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

529709:PYCH RS03485
gene id: 529709:PYCH_RS03485
uniprot id: F8AIM6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

529709:PYCH RS02605
gene id: 529709:PYCH_RS02605
uniprot id: F8AHT5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

529709:PYCH RS07990
gene id: 529709:PYCH_RS07990
uniprot id: F8AH70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

529709:PYCH RS02320
gene id: 529709:PYCH_RS02320
uniprot id: F8AHG4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

529709:PYCH RS07770
gene id: 529709:PYCH_RS07770
uniprot id: F8AGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS04715
gene id: 529709:PYCH_RS04715
uniprot id: F8AED0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

529709:PYCH RS01745
gene id: 529709:PYCH_RS01745
uniprot id: F8AGZ7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

529709:PYCH RS02995
gene id: 529709:PYCH_RS02995
uniprot id: F8AI71
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

529709:PYCH RS06510
gene id: 529709:PYCH_RS06510
uniprot id: F8AFM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

529709:PYCH RS09070
gene id: 529709:PYCH_RS09070
uniprot id: F8AEG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

529709:PYCH RS03235
gene id: 529709:PYCH_RS03235
uniprot id: F8AII3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

529709:PYCH RS03630
gene id: 529709:PYCH_RS03630
uniprot id: F8AIV2
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

529709:PYCH RS08400
gene id: 529709:PYCH_RS08400
uniprot id: F8AHK4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

529709:PYCH RS00555
gene id: 529709:PYCH_RS00555
uniprot id: F8AFS6
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

529709:PYCH RS06610
gene id: 529709:PYCH_RS06610
uniprot id: F8AFP1
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS03155
gene id: 529709:PYCH_RS03155
uniprot id: F8AI94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

529709:PYCH RS05000
gene id: 529709:PYCH_RS05000
uniprot id: F8AEM9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

529709:PYCH RS07105
gene id: 529709:PYCH_RS07105
uniprot id: F8AGC2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

529709:PYCH RS06770
gene id: 529709:PYCH_RS06770
uniprot id: F8AFZ5
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS07645
gene id: 529709:PYCH_RS07645
uniprot id: F8AGU1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

529709:PYCH RS00355
gene id: 529709:PYCH_RS00355
uniprot id: F8AFH7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

529709:PYCH RS05165
gene id: 529709:PYCH_RS05165
uniprot id: F8AEQ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

529709:PYCH RS08320
gene id: 529709:PYCH_RS08320
uniprot id: F8AHI7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

529709:PYCH RS04680
gene id: 529709:PYCH_RS04680
uniprot id: F8AJ42
names: Similarity
messages: Belongs to the NodU/CmcH family.

529709:PYCH RS05260
gene id: 529709:PYCH_RS05260
uniprot id: F8AES6
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS02260
gene id: 529709:PYCH_RS02260
uniprot id: F8AHF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

529709:PYCH RS00385
gene id: 529709:PYCH_RS00385
uniprot id: F8AFI0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

529709:PYCH RS07970
gene id: 529709:PYCH_RS07970
uniprot id: F8AH66
names: Similarity
messages: Belongs to the glutaredoxin family.

529709:PYCH RS04575
gene id: 529709:PYCH_RS04575
uniprot id: F8AEA6
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS05635
gene id: 529709:PYCH_RS05635
uniprot id: F8AEZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS05270
gene id: 529709:PYCH_RS05270
uniprot id: F8AES8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

529709:PYCH RS00730
gene id: 529709:PYCH_RS00730
uniprot id: F8AFW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS07660
gene id: 529709:PYCH_RS07660
uniprot id: F8AGU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

529709:PYCH RS02775
gene id: 529709:PYCH_RS02775
uniprot id: F8AHW7
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

529709:PYCH RS08575
gene id: 529709:PYCH_RS08575
uniprot id: F8AEF1
names: Similarity
messages: Belongs to the peptidase S9C family.

529709:PYCH RS09290
gene id: 529709:PYCH_RS09290
uniprot id: F8AIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS01365
gene id: 529709:PYCH_RS01365
uniprot id: F8AGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

529709:PYCH RS08935
gene id: 529709:PYCH_RS08935
uniprot id: F8AI18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

529709:PYCH RS01475
gene id: 529709:PYCH_RS01475
uniprot id: F8AGN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

529709:PYCH RS01200
gene id: 529709:PYCH_RS01200
uniprot id: F8AGB4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

529709:PYCH RS02370
gene id: 529709:PYCH_RS02370
uniprot id: F8AHH1
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

529709:PYCH RS03780
gene id: 529709:PYCH_RS03780
uniprot id: F8AIY2
names: Similarity
messages: Belongs to the peptidase M24B family.

529709:PYCH RS08110
gene id: 529709:PYCH_RS08110
uniprot id: F8AH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS01535
gene id: 529709:PYCH_RS01535
uniprot id: F8AGP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS07810
gene id: 529709:PYCH_RS07810
uniprot id: F8AGX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

529709:PYCH RS01235
gene id: 529709:PYCH_RS01235
uniprot id: F8AGB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

529709:PYCH RS08910
gene id: 529709:PYCH_RS08910
uniprot id: F8AEG1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS06550
gene id: 529709:PYCH_RS06550
uniprot id: F8AFN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS07545
gene id: 529709:PYCH_RS07545
uniprot id: F8AGS1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

529709:PYCH RS07685
gene id: 529709:PYCH_RS07685
uniprot id: F8AGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

529709:PYCH RS08875
gene id: 529709:PYCH_RS08875
uniprot id: F8AI10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

529709:PYCH RS04900
gene id: 529709:PYCH_RS04900
uniprot id: F8AEK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

529709:PYCH RS07955
gene id: 529709:PYCH_RS07955
uniprot id: F8AH61
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

529709:PYCH RS01045
gene id: 529709:PYCH_RS01045
uniprot id: F8AG90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS00405
gene id: 529709:PYCH_RS00405
uniprot id: F8AIH5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

529709:PYCH RS00175
gene id: 529709:PYCH_RS00175
uniprot id: F8AFE5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

529709:PYCH RS03005
gene id: 529709:PYCH_RS03005
uniprot id: F8AIT4
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

529709:PYCH RS04945
gene id: 529709:PYCH_RS04945
uniprot id: F8AEL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

529709:PYCH RS02100
gene id: 529709:PYCH_RS02100
uniprot id: F8AHC2
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS04760
gene id: 529709:PYCH_RS04760
uniprot id: F8AJ44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

529709:PYCH RS00740
gene id: 529709:PYCH_RS00740
uniprot id: F8AFW2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

529709:PYCH RS05445
gene id: 529709:PYCH_RS05445
uniprot id: F8AEW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS09415
gene id: 529709:PYCH_RS09415
uniprot id: F8AIG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

529709:PYCH RS08375
gene id: 529709:PYCH_RS08375
uniprot id: F8AHJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS02275
gene id: 529709:PYCH_RS02275
uniprot id: F8AHF6
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS03685
gene id: 529709:PYCH_RS03685
uniprot id: F8AIW3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

529709:PYCH RS01260
gene id: 529709:PYCH_RS01260
uniprot id: F8AGJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS00340
gene id: 529709:PYCH_RS00340
uniprot id: F8AFH5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

529709:PYCH RS09225
gene id: 529709:PYCH_RS09225
uniprot id: F8AID6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

529709:PYCH RS00130
gene id: 529709:PYCH_RS00130
uniprot id: F8AFD0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

529709:PYCH RS07095
gene id: 529709:PYCH_RS07095
uniprot id: F8AG55
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

529709:PYCH RS01910
gene id: 529709:PYCH_RS01910
uniprot id: F8AH23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

529709:PYCH RS08905
gene id: 529709:PYCH_RS08905
uniprot id: F8AI14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

529709:PYCH RS01925
gene id: 529709:PYCH_RS01925
uniprot id: F8AH25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

529709:PYCH RS01170
gene id: 529709:PYCH_RS01170
uniprot id: F8AGB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

529709:PYCH RS07865
gene id: 529709:PYCH_RS07865
uniprot id: F8AED9
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

529709:PYCH RS04375
gene id: 529709:PYCH_RS04375
uniprot id: F8AE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

529709:PYCH RS07255
gene id: 529709:PYCH_RS07255
uniprot id: F8AGF3
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS05915
gene id: 529709:PYCH_RS05915
uniprot id: F8AF37
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

529709:PYCH RS02655
gene id: 529709:PYCH_RS02655
uniprot id: F8AHU3
names: Similarity
messages: Belongs to the AOR/FOR family.

529709:PYCH RS05545
gene id: 529709:PYCH_RS05545
uniprot id: F8AEX9
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS01915
gene id: 529709:PYCH_RS01915
uniprot id: F8AIR3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

529709:PYCH RS04630
gene id: 529709:PYCH_RS04630
uniprot id: F8AEB6
names: Similarity
messages: Belongs to the AOR/FOR family.

529709:PYCH RS00725
gene id: 529709:PYCH_RS00725
uniprot id: F8AFV9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS05015
gene id: 529709:PYCH_RS05015
uniprot id: F8AEN2
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS01140
gene id: 529709:PYCH_RS01140
uniprot id: F8AGA7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

529709:PYCH RS09075
gene id: 529709:PYCH_RS09075
uniprot id: F8AI36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

529709:PYCH RS00135
gene id: 529709:PYCH_RS00135
uniprot id: F8AFD1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

529709:PYCH RS08415
gene id: 529709:PYCH_RS08415
uniprot id: F8AHK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

529709:PYCH RS01480
gene id: 529709:PYCH_RS01480
uniprot id: F8AIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

529709:PYCH RS00480
gene id: 529709:PYCH_RS00480
uniprot id: F8AIP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS03930
gene id: 529709:PYCH_RS03930
uniprot id: F8AJ31
names: Similarity
messages: Belongs to the UPF0284 family.

529709:PYCH RS03625
gene id: 529709:PYCH_RS03625
uniprot id: F8AIV1
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

529709:PYCH RS04515
gene id: 529709:PYCH_RS04515
uniprot id: F8AE94
names: Similarity
messages: Belongs to the UPF0248 family.

529709:PYCH RS09160
gene id: 529709:PYCH_RS09160
uniprot id: F8AIC2
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

529709:PYCH RS03335
gene id: 529709:PYCH_RS03335
uniprot id: F8AIK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

529709:PYCH RS04610
gene id: 529709:PYCH_RS04610
uniprot id: F8AEB3
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS02940
gene id: 529709:PYCH_RS02940
uniprot id: F8AI60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

529709:PYCH RS08140
gene id: 529709:PYCH_RS08140
uniprot id: F8AH99
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

529709:PYCH RS01190
gene id: 529709:PYCH_RS01190
uniprot id: F8AGB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

529709:PYCH RS03370
gene id: 529709:PYCH_RS03370
uniprot id: F8AIL0
names: Similarity
messages: Belongs to the AOR/FOR family.

529709:PYCH RS07830
gene id: 529709:PYCH_RS07830
uniprot id: F8AGX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

529709:PYCH RS07085
gene id: 529709:PYCH_RS07085
uniprot id: F8AG53
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

529709:PYCH RS05455
gene id: 529709:PYCH_RS05455
uniprot id: F8AEW5
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS07985
gene id: 529709:PYCH_RS07985
uniprot id: F8AH69
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

529709:PYCH RS00615
gene id: 529709:PYCH_RS00615
uniprot id: F8AFT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

529709:PYCH RS06805
gene id: 529709:PYCH_RS06805
uniprot id: F8AG01
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS05705
gene id: 529709:PYCH_RS05705
uniprot id: F8AF11
names: Similarity
messages: Belongs to the UPF0128 family.

529709:PYCH RS02085
gene id: 529709:PYCH_RS02085
uniprot id: F8AHB9
names: Similarity
messages: Belongs to the thioesterase PaaI family.

529709:PYCH RS08965
gene id: 529709:PYCH_RS08965
uniprot id: F8AEG4
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

529709:PYCH RS09090
gene id: 529709:PYCH_RS09090
uniprot id: F8AIA7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

529709:PYCH RS05940
gene id: 529709:PYCH_RS05940
uniprot id: F8AF61
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS04160
gene id: 529709:PYCH_RS04160
uniprot id: F8AJ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS03415
gene id: 529709:PYCH_RS03415
uniprot id: F8AIL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. MPGP family.
messages: Cytoplasm
messages: Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG).

529709:PYCH RS03385
gene id: 529709:PYCH_RS03385
uniprot id: F8AIL3
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS05275
gene id: 529709:PYCH_RS05275
uniprot id: F8AES9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

529709:PYCH RS04995
gene id: 529709:PYCH_RS04995
uniprot id: F8AEM8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS00415
gene id: 529709:PYCH_RS00415
uniprot id: F8AFI5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

529709:PYCH RS00775
gene id: 529709:PYCH_RS00775
uniprot id: F8AFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

529709:PYCH RS09340
gene id: 529709:PYCH_RS09340
uniprot id: F8AEH3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

529709:PYCH RS08900
gene id: 529709:PYCH_RS08900
uniprot id: F8AEG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

529709:PYCH RS01250
gene id: 529709:PYCH_RS01250
uniprot id: F8AGC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

529709:PYCH RS03200
gene id: 529709:PYCH_RS03200
uniprot id: F8AIA2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

529709:PYCH RS03585
gene id: 529709:PYCH_RS03585
uniprot id: F8AIU4
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

529709:PYCH RS03500
gene id: 529709:PYCH_RS03500
uniprot id: F8AIM9
names: Similarity
messages: Belongs to the peptidase U62 family.

529709:PYCH RS06035
gene id: 529709:PYCH_RS06035
uniprot id: F8AF78
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

529709:PYCH RS03110
gene id: 529709:PYCH_RS03110
uniprot id: F8AIT9
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS08990
gene id: 529709:PYCH_RS08990
uniprot id: F8AI25
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

529709:PYCH RS04595
gene id: 529709:PYCH_RS04595
uniprot id: F8AEB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

529709:PYCH RS01675
gene id: 529709:PYCH_RS01675
uniprot id: F8AGY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

529709:PYCH RS09205
gene id: 529709:PYCH_RS09205
uniprot id: F8AID1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS04355
gene id: 529709:PYCH_RS04355
uniprot id: F8AJC7
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

529709:PYCH RS04685
gene id: 529709:PYCH_RS04685
uniprot id: F8AEC4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

529709:PYCH RS06000
gene id: 529709:PYCH_RS06000
uniprot id: F8AF73
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

529709:PYCH RS02430
gene id: 529709:PYCH_RS02430
uniprot id: F8AIS5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

529709:PYCH RS00755
gene id: 529709:PYCH_RS00755
uniprot id: F8AFW4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

529709:PYCH RS00765
gene id: 529709:PYCH_RS00765
uniprot id: F8AFW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

529709:PYCH RS02750
gene id: 529709:PYCH_RS02750
uniprot id: F8AHW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

529709:PYCH RS05890
gene id: 529709:PYCH_RS05890
uniprot id: F8AF34
names: Similarity
messages: Belongs to the UPF0251 family.

529709:PYCH RS07275
gene id: 529709:PYCH_RS07275
uniprot id: F8AGF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

529709:PYCH RS02440
gene id: 529709:PYCH_RS02440
uniprot id: F8AIS6
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

529709:PYCH RS01205
gene id: 529709:PYCH_RS01205
uniprot id: F8AGB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

529709:PYCH RS01015
gene id: 529709:PYCH_RS01015
uniprot id: F8AG85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

529709:PYCH RS00205
gene id: 529709:PYCH_RS00205
uniprot id: F8AFF3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

529709:PYCH RS02045
gene id: 529709:PYCH_RS02045
uniprot id: F8AH44
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS02740
gene id: 529709:PYCH_RS02740
uniprot id: F8AHV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

529709:PYCH RS08930
gene id: 529709:PYCH_RS08930
uniprot id: F8AI17
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

529709:PYCH RS02075
gene id: 529709:PYCH_RS02075
uniprot id: F8AHB7
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS04590
gene id: 529709:PYCH_RS04590
uniprot id: F8AEA9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

529709:PYCH RS01305
gene id: 529709:PYCH_RS01305
uniprot id: F8AGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

529709:PYCH RS06480
gene id: 529709:PYCH_RS06480
uniprot id: F8AFM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

529709:PYCH RS01515
gene id: 529709:PYCH_RS01515
uniprot id: F8AGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS05365
gene id: 529709:PYCH_RS05365
uniprot id: F8AEU6
names: Similarity
messages: Belongs to the FrhG family.

529709:PYCH RS01330
gene id: 529709:PYCH_RS01330
uniprot id: F8AGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS08885
gene id: 529709:PYCH_RS08885
uniprot id: F8AEF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

529709:PYCH RS09400
gene id: 529709:PYCH_RS09400
uniprot id: F8AIG2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

529709:PYCH RS02990
gene id: 529709:PYCH_RS02990
uniprot id: F8AI70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

529709:PYCH RS01595
gene id: 529709:PYCH_RS01595
uniprot id: F8AGQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

529709:PYCH RS07915
gene id: 529709:PYCH_RS07915
uniprot id: F8AH53
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

529709:PYCH RS00665
gene id: 529709:PYCH_RS00665
uniprot id: F8AFU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

529709:PYCH RS07775
gene id: 529709:PYCH_RS07775
uniprot id: F8AGW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS03940
gene id: 529709:PYCH_RS03940
uniprot id: F8AJ09
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

529709:PYCH RS04010
gene id: 529709:PYCH_RS04010
uniprot id: F8AJ66
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS03615
gene id: 529709:PYCH_RS03615
uniprot id: F8AIV0
names: Similarity
messages: Belongs to the UPF0111 family.

529709:PYCH RS05660
gene id: 529709:PYCH_RS05660
uniprot id: F8AF03
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS09115
gene id: 529709:PYCH_RS09115
uniprot id: F8AIB2
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

529709:PYCH RS05145
gene id: 529709:PYCH_RS05145
uniprot id: F8AEQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS01100
gene id: 529709:PYCH_RS01100
uniprot id: F8AGA1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

529709:PYCH RS06565
gene id: 529709:PYCH_RS06565
uniprot id: F8AJE7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

529709:PYCH RS07925
gene id: 529709:PYCH_RS07925
uniprot id: F8AH55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

529709:PYCH RS02550
gene id: 529709:PYCH_RS02550
uniprot id: F8AHS4
names: Similarity
messages: Belongs to the UPF0235 family.

529709:PYCH RS01855
gene id: 529709:PYCH_RS01855
uniprot id: F8AH16
names: Similarity
messages: Belongs to the SDO1/SBDS family.

529709:PYCH RS01930
gene id: 529709:PYCH_RS01930
uniprot id: F8AIR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS05305
gene id: 529709:PYCH_RS05305
uniprot id: F8AET5
names: Similarity
messages: Belongs to the peptidase S9C family.

529709:PYCH RS03040
gene id: 529709:PYCH_RS03040
uniprot id: F8AI78
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

529709:PYCH RS06385
gene id: 529709:PYCH_RS06385
uniprot id: F8AFK3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

529709:PYCH RS02200
gene id: 529709:PYCH_RS02200
uniprot id: F8AHE1
names: Similarity
messages: Belongs to the UPF0047 family.

529709:PYCH RS03540
gene id: 529709:PYCH_RS03540
uniprot id: F8AIN7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

529709:PYCH RS06615
gene id: 529709:PYCH_RS06615
uniprot id: F8AFP2
names: Similarity
messages: Belongs to the GbsR family.

529709:PYCH RS01920
gene id: 529709:PYCH_RS01920
uniprot id: F8AH24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

529709:PYCH RS07855
gene id: 529709:PYCH_RS07855
uniprot id: F8AJI0
names: Similarity
messages: Belongs to the GARS family.

529709:PYCH RS08625
gene id: 529709:PYCH_RS08625
uniprot id: F8AEF4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

529709:PYCH RS01245
gene id: 529709:PYCH_RS01245
uniprot id: F8AGC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS02135
gene id: 529709:PYCH_RS02135
uniprot id: F8AHC9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

529709:PYCH RS00080
gene id: 529709:PYCH_RS00080
uniprot id: F8AF54
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

529709:PYCH RS07065
gene id: 529709:PYCH_RS07065
uniprot id: F8AJG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

529709:PYCH RS03665
gene id: 529709:PYCH_RS03665
uniprot id: F8AIV9
names: Similarity
messages: Belongs to the UPF0047 family.

529709:PYCH RS09105
gene id: 529709:PYCH_RS09105
uniprot id: F8AIB0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

529709:PYCH RS07560
gene id: 529709:PYCH_RS07560
uniprot id: F8AGS4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

529709:PYCH RS00455
gene id: 529709:PYCH_RS00455
uniprot id: F8AFJ2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

529709:PYCH RS09195
gene id: 529709:PYCH_RS09195
uniprot id: F8AIC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

529709:PYCH RS06065
gene id: 529709:PYCH_RS06065
uniprot id: F8AF84
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS05655
gene id: 529709:PYCH_RS05655
uniprot id: F8AF01
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

529709:PYCH RS04230
gene id: 529709:PYCH_RS04230
uniprot id: F8AJA7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS09170
gene id: 529709:PYCH_RS09170
uniprot id: F8AIC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

529709:PYCH RS00050
gene id: 529709:PYCH_RS00050
uniprot id: F8AF48
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

529709:PYCH RS04915
gene id: 529709:PYCH_RS04915
uniprot id: F8AEL0
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

529709:PYCH RS01285
gene id: 529709:PYCH_RS01285
uniprot id: F8AGJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

529709:PYCH RS01735
gene id: 529709:PYCH_RS01735
uniprot id: F8AGZ5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

529709:PYCH RS04305
gene id: 529709:PYCH_RS04305
uniprot id: F8AJB7
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS08385
gene id: 529709:PYCH_RS08385
uniprot id: F8AHK1
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS06150
gene id: 529709:PYCH_RS06150
uniprot id: F8AF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

529709:PYCH RS01790
gene id: 529709:PYCH_RS01790
uniprot id: F8AH03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

529709:PYCH RS02340
gene id: 529709:PYCH_RS02340
uniprot id: F8AIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

529709:PYCH RS00650
gene id: 529709:PYCH_RS00650
uniprot id: F8AFU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

529709:PYCH RS07520
gene id: 529709:PYCH_RS07520
uniprot id: F8AGR6
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS05340
gene id: 529709:PYCH_RS05340
uniprot id: F8AEU1
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

529709:PYCH RS03085
gene id: 529709:PYCH_RS03085
uniprot id: F8AI85
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

529709:PYCH RS05080
gene id: 529709:PYCH_RS05080
uniprot id: F8AEP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

529709:PYCH RS06195
gene id: 529709:PYCH_RS06195
uniprot id: F8AFA2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

529709:PYCH RS05005
gene id: 529709:PYCH_RS05005
uniprot id: F8AEN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

529709:PYCH RS01585
gene id: 529709:PYCH_RS01585
uniprot id: F8AGQ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

529709:PYCH RS07090
gene id: 529709:PYCH_RS07090
uniprot id: F8AG54
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

529709:PYCH RS05500
gene id: 529709:PYCH_RS05500
uniprot id: F8AEX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS04905
gene id: 529709:PYCH_RS04905
uniprot id: F8AEK8
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS06105
gene id: 529709:PYCH_RS06105
uniprot id: F8AF92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

529709:PYCH RS05095
gene id: 529709:PYCH_RS05095
uniprot id: F8AEP5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

529709:PYCH RS08405
gene id: 529709:PYCH_RS08405
uniprot id: F8AHK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

529709:PYCH RS06895
gene id: 529709:PYCH_RS06895
uniprot id: F8AG19
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

529709:PYCH RS01710
gene id: 529709:PYCH_RS01710
uniprot id: F8AGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

529709:PYCH RS04980
gene id: 529709:PYCH_RS04980
uniprot id: F8AEM5
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

529709:PYCH RS08605
gene id: 529709:PYCH_RS08605
uniprot id: F8AEF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS05390
gene id: 529709:PYCH_RS05390
uniprot id: F8AEV3
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS03090
gene id: 529709:PYCH_RS03090
uniprot id: F8AI86
names: Similarity
messages: Belongs to the band 7/mec-2 family.

529709:PYCH RS06360
gene id: 529709:PYCH_RS06360
uniprot id: F8AFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

529709:PYCH RS01165
gene id: 529709:PYCH_RS01165
uniprot id: F8AIQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

529709:PYCH RS07835
gene id: 529709:PYCH_RS07835
uniprot id: F8AJH9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS04660
gene id: 529709:PYCH_RS04660
uniprot id: F8AEC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

529709:PYCH RS09220
gene id: 529709:PYCH_RS09220
uniprot id: F8AID5
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

529709:PYCH RS05920
gene id: 529709:PYCH_RS05920
uniprot id: F8AF38
names: Similarity
messages: Belongs to the RutC family.

529709:PYCH RS05615
gene id: 529709:PYCH_RS05615
uniprot id: F8AEZ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS05375
gene id: 529709:PYCH_RS05375
uniprot id: F8AJ49
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

529709:PYCH RS03095
gene id: 529709:PYCH_RS03095
uniprot id: F8AI87
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS06110
gene id: 529709:PYCH_RS06110
uniprot id: F8AJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

529709:PYCH RS06595
gene id: 529709:PYCH_RS06595
uniprot id: F8AJF0
names: Similarity
messages: Belongs to the UPF0045 family.

529709:PYCH RS07140
gene id: 529709:PYCH_RS07140
uniprot id: F8AGD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

529709:PYCH RS02240
gene id: 529709:PYCH_RS02240
uniprot id: F8AHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS03065
gene id: 529709:PYCH_RS03065
uniprot id: F8AI82
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS09330
gene id: 529709:PYCH_RS09330
uniprot id: F8AEH2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

529709:PYCH RS00460
gene id: 529709:PYCH_RS00460
uniprot id: F8AFJ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

529709:PYCH RS04875
gene id: 529709:PYCH_RS04875
uniprot id: F8AEK2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS04755
gene id: 529709:PYCH_RS04755
uniprot id: F8AED7
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

529709:PYCH RS01375
gene id: 529709:PYCH_RS01375
uniprot id: F8AGL5
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

529709:PYCH RS08155
gene id: 529709:PYCH_RS08155
uniprot id: F8AHA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

529709:PYCH RS08270
gene id: 529709:PYCH_RS08270
uniprot id: F8AHB1
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS00085
gene id: 529709:PYCH_RS00085
uniprot id: F8AF55
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

529709:PYCH RS03180
gene id: 529709:PYCH_RS03180
uniprot id: F8AI98
names: Similarity
messages: Belongs to the HupF/HypC family.

529709:PYCH RS04565
gene id: 529709:PYCH_RS04565
uniprot id: F8AEA4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS06580
gene id: 529709:PYCH_RS06580
uniprot id: F8AFN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

529709:PYCH RS08570
gene id: 529709:PYCH_RS08570
uniprot id: F8AHN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

529709:PYCH RS09250
gene id: 529709:PYCH_RS09250
uniprot id: F8AIE1
names: Similarity
messages: Belongs to the UPF0216 family.

529709:PYCH RS05085
gene id: 529709:PYCH_RS05085
uniprot id: F8AJ48
names: Similarity
messages: Belongs to the UPF0111 family.

529709:PYCH RS05630
gene id: 529709:PYCH_RS05630
uniprot id: F8AEZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS07480
gene id: 529709:PYCH_RS07480
uniprot id: F8AGJ0
names: Similarity
messages: Belongs to the HerA family.

529709:PYCH RS03140
gene id: 529709:PYCH_RS03140
uniprot id: F8AIU2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

529709:PYCH RS06475
gene id: 529709:PYCH_RS06475
uniprot id: F8AFM0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

529709:PYCH RS03770
gene id: 529709:PYCH_RS03770
uniprot id: F8AIY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

529709:PYCH RS00315
gene id: 529709:PYCH_RS00315
uniprot id: F8AFH2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

529709:PYCH RS08685
gene id: 529709:PYCH_RS08685
uniprot id: F8AHX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

529709:PYCH RS01690
gene id: 529709:PYCH_RS01690
uniprot id: F8AGY7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

529709:PYCH RS07080
gene id: 529709:PYCH_RS07080
uniprot id: F8AG52
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

529709:PYCH RS01550
gene id: 529709:PYCH_RS01550
uniprot id: F8AGP5
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS02850
gene id: 529709:PYCH_RS02850
uniprot id: F8AI43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

529709:PYCH RS03265
gene id: 529709:PYCH_RS03265
uniprot id: F8AII9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

529709:PYCH RS05580
gene id: 529709:PYCH_RS05580
uniprot id: F8AEY6
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

529709:PYCH RS07145
gene id: 529709:PYCH_RS07145
uniprot id: F8AGD3
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

529709:PYCH RS08380
gene id: 529709:PYCH_RS08380
uniprot id: F8AHK0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

529709:PYCH RS02065
gene id: 529709:PYCH_RS02065
uniprot id: F8AHB5
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

529709:PYCH RS00020
gene id: 529709:PYCH_RS00020
uniprot id: F8AF42
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

529709:PYCH RS07700
gene id: 529709:PYCH_RS07700
uniprot id: F8AGV1
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

529709:PYCH RS02455
gene id: 529709:PYCH_RS02455
uniprot id: F8AHQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

529709:PYCH RS01605
gene id: 529709:PYCH_RS01605
uniprot id: F8AGQ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

529709:PYCH RS00660
gene id: 529709:PYCH_RS00660
uniprot id: F8AFU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

529709:PYCH RS02300
gene id: 529709:PYCH_RS02300
uniprot id: F8AHG1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

529709:PYCH RS09305
gene id: 529709:PYCH_RS09305
uniprot id: F8AIF0
names: Similarity
messages: Belongs to the MoaB/Mog family.

529709:PYCH RS07705
gene id: 529709:PYCH_RS07705
uniprot id: F8AGV2
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

529709:PYCH RS08880
gene id: 529709:PYCH_RS08880
uniprot id: F8AI11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

529709:PYCH RS06695
gene id: 529709:PYCH_RS06695
uniprot id: F8AFQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

529709:PYCH RS05105
gene id: 529709:PYCH_RS05105
uniprot id: F8AEP7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS02600
gene id: 529709:PYCH_RS02600
uniprot id: F8AHT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

529709:PYCH RS07580
gene id: 529709:PYCH_RS07580
uniprot id: F8AGS8
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

529709:PYCH RS00720
gene id: 529709:PYCH_RS00720
uniprot id: F8AFV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

529709:PYCH RS07720
gene id: 529709:PYCH_RS07720
uniprot id: F8AGV4
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

529709:PYCH RS07795
gene id: 529709:PYCH_RS07795
uniprot id: F8AJH6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

529709:PYCH RS00150
gene id: 529709:PYCH_RS00150
uniprot id: F8AFD4
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

529709:PYCH RS00735
gene id: 529709:PYCH_RS00735
uniprot id: F8AFW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

529709:PYCH RS03935
gene id: 529709:PYCH_RS03935
uniprot id: F8AJ08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

529709:PYCH RS00750
gene id: 529709:PYCH_RS00750
uniprot id: F8AFW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

529709:PYCH RS06710
gene id: 529709:PYCH_RS06710
uniprot id: F8AFR0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

529709:PYCH RS03225
gene id: 529709:PYCH_RS03225
uniprot id: F8AIH8
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS07800
gene id: 529709:PYCH_RS07800
uniprot id: F8AGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

529709:PYCH RS00700
gene id: 529709:PYCH_RS00700
uniprot id: F8AFV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS08695
gene id: 529709:PYCH_RS08695
uniprot id: F8AHX8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

529709:PYCH RS01510
gene id: 529709:PYCH_RS01510
uniprot id: F8AGN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

529709:PYCH RS08655
gene id: 529709:PYCH_RS08655
uniprot id: F8AHP8
names: Similarity
messages: Belongs to the UDPGP type 2 family.

529709:PYCH RS05560
gene id: 529709:PYCH_RS05560
uniprot id: F8AEY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

529709:PYCH RS07965
gene id: 529709:PYCH_RS07965
uniprot id: F8AH65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

529709:PYCH RS08600
gene id: 529709:PYCH_RS08600
uniprot id: F8AHP0
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

529709:PYCH RS00810
gene id: 529709:PYCH_RS00810
uniprot id: F8AIQ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

529709:PYCH RS03920
gene id: 529709:PYCH_RS03920
uniprot id: F8AJ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

529709:PYCH RS00485
gene id: 529709:PYCH_RS00485
uniprot id: F8AFJ5
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

529709:PYCH RS06720
gene id: 529709:PYCH_RS06720
uniprot id: F8AFR2
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

529709:PYCH RS06420
gene id: 529709:PYCH_RS06420
uniprot id: F8AFL0
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

529709:PYCH RS06910
gene id: 529709:PYCH_RS06910
uniprot id: F8AG24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

529709:PYCH RS03845
gene id: 529709:PYCH_RS03845
uniprot id: F8AJ25
names: Similarity
messages: Belongs to the pyruvate kinase family.

529709:PYCH RS03290
gene id: 529709:PYCH_RS03290
uniprot id: F8AIJ4
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

529709:PYCH RS02620
gene id: 529709:PYCH_RS02620
uniprot id: F8AHT8
names: Similarity
messages: Belongs to the UPF0127 family.

529709:PYCH RS07920
gene id: 529709:PYCH_RS07920
uniprot id: F8AH54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

529709:PYCH RS00995
gene id: 529709:PYCH_RS00995
uniprot id: F8AG81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

529709:PYCH RS02935
gene id: 529709:PYCH_RS02935
uniprot id: F8AI59
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

529709:PYCH RS03465
gene id: 529709:PYCH_RS03465
uniprot id: F8AIM4
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

529709:PYCH RS02540
gene id: 529709:PYCH_RS02540
uniprot id: F8AHS2
names: Similarity
messages: Belongs to the HypE family.

529709:PYCH RS05755
gene id: 529709:PYCH_RS05755
uniprot id: F8AF17
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

529709:PYCH RS03860
gene id: 529709:PYCH_RS03860
uniprot id: F8AIZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

529709:PYCH RS03240
gene id: 529709:PYCH_RS03240
uniprot id: F8AII4
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

529709:PYCH RS01010
gene id: 529709:PYCH_RS01010
uniprot id: F8AG84
names: Similarity
messages: Belongs to the thymidylate kinase family.

529709:PYCH RS04145
gene id: 529709:PYCH_RS04145
uniprot id: F8AJ92
names: Similarity
messages: Belongs to the glutaredoxin family.

529709:PYCH RS02385
gene id: 529709:PYCH_RS02385
uniprot id: F8AIS2
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

529709:PYCH RS06690
gene id: 529709:PYCH_RS06690
uniprot id: F8AFQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

529709:PYCH RS04370
gene id: 529709:PYCH_RS04370
uniprot id: F8AE66
names: Subcellular Location Annotation
messages: Cytoplasm

529709:PYCH RS06530
gene id: 529709:PYCH_RS06530
uniprot id: F8AFN2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

529709:PYCH RS08540
gene id: 529709:PYCH_RS08540
uniprot id: F8AHN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

529709:PYCH RS01225
gene id: 529709:PYCH_RS01225
uniprot id: F8AGB7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

529709:PYCH RS07135
gene id: 529709:PYCH_RS07135
uniprot id: F8AGD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

529709:PYCH RS01695
gene id: 529709:PYCH_RS01695
uniprot id: F8AGY8
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

529709:PYCH RS00245
gene id: 529709:PYCH_RS00245
uniprot id: F8AFG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS06845
gene id: 529709:PYCH_RS06845
uniprot id: F8AG09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

529709:PYCH RS00345
gene id: 529709:PYCH_RS00345
uniprot id: F8AFH6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

529709:PYCH RS03060
gene id: 529709:PYCH_RS03060
uniprot id: F8AIT6
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

529709:PYCH RS05570
gene id: 529709:PYCH_RS05570
uniprot id: F8AEY4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS01370
gene id: 529709:PYCH_RS01370
uniprot id: F8AGL4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

529709:PYCH RS03690
gene id: 529709:PYCH_RS03690
uniprot id: F8AIW4
names: Similarity
messages: Belongs to the peptidase S8 family.

529709:PYCH RS07695
gene id: 529709:PYCH_RS07695
uniprot id: F8AJH1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

529709:PYCH RS02465
gene id: 529709:PYCH_RS02465
uniprot id: F8AHQ6
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS00440
gene id: 529709:PYCH_RS00440
uniprot id: F8AFJ0
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

529709:PYCH RS02025
gene id: 529709:PYCH_RS02025
uniprot id: F8AH41
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS00320
gene id: 529709:PYCH_RS00320
uniprot id: F8AFH3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

529709:PYCH RS01810
gene id: 529709:PYCH_RS01810
uniprot id: F8AH07
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

529709:PYCH RS04805
gene id: 529709:PYCH_RS04805
uniprot id: F8AEI8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

529709:PYCH RS03580
gene id: 529709:PYCH_RS03580
uniprot id: F8AIP4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

529709:PYCH RS03325
gene id: 529709:PYCH_RS03325
uniprot id: F8AIK1
names: Similarity
messages: Belongs to the UPF0148 family.

529709:PYCH RS09325
gene id: 529709:PYCH_RS09325
uniprot id: F8AIF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

529709:PYCH RS04060
gene id: 529709:PYCH_RS04060
uniprot id: F8AJ75
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

529709:PYCH RS09285
gene id: 529709:PYCH_RS09285
uniprot id: F8AIE6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

529709:PYCH RS07675
gene id: 529709:PYCH_RS07675
uniprot id: F8AGU7
names: Function
messages: Part of a potassium transport system.

529709:PYCH RS09005
gene id: 529709:PYCH_RS09005
uniprot id: F8AI27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

529709:PYCH RS09425
gene id: 529709:PYCH_RS09425
uniprot id: F8AIG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

529709:PYCH RS00710
gene id: 529709:PYCH_RS00710
uniprot id: F8AIP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

529709:PYCH RS02875
gene id: 529709:PYCH_RS02875
uniprot id: F8AI48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

529709:PYCH RS07530
gene id: 529709:PYCH_RS07530
uniprot id: F8AGR8
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS00690
gene id: 529709:PYCH_RS00690
uniprot id: F8AFV3
names: Similarity
messages: Belongs to the SUI1 family.

529709:PYCH RS01715
gene id: 529709:PYCH_RS01715
uniprot id: F8AGZ2
names: Similarity
messages: Belongs to the HypE family.

529709:PYCH RS03470
gene id: 529709:PYCH_RS03470
uniprot id: F8AIM5
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

529709:PYCH RS08765
gene id: 529709:PYCH_RS08765
uniprot id: F8AHZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

529709:PYCH RS00685
gene id: 529709:PYCH_RS00685
uniprot id: F8AFV2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

529709:PYCH RS04880
gene id: 529709:PYCH_RS04880
uniprot id: F8AEK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

529709:PYCH RS01135
gene id: 529709:PYCH_RS01135
uniprot id: F8AGA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

529709:PYCH RS08895
gene id: 529709:PYCH_RS08895
uniprot id: F8AI13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

529709:PYCH RS08105
gene id: 529709:PYCH_RS08105
uniprot id: F8AH93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS02545
gene id: 529709:PYCH_RS02545
uniprot id: F8AHS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

529709:PYCH RS05965
gene id: 529709:PYCH_RS05965
uniprot id: F8AF66
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

529709:PYCH RS06810
gene id: 529709:PYCH_RS06810
uniprot id: F8AG02
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

529709:PYCH RS01975
gene id: 529709:PYCH_RS01975
uniprot id: F8AIR6
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

529709:PYCH RS00140
gene id: 529709:PYCH_RS00140
uniprot id: F8AFD2
names: Similarity
messages: Belongs to the ZPR1 family.

529709:PYCH RS00815
gene id: 529709:PYCH_RS00815
uniprot id: F8AFX4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

529709:PYCH RS04555
gene id: 529709:PYCH_RS04555
uniprot id: F8AEA2
names: Similarity
messages: Belongs to the FUN14 family.

529709:PYCH RS01230
gene id: 529709:PYCH_RS01230
uniprot id: F8AIQ7
names: Similarity
messages: Belongs to the MEMO1 family.

529709:PYCH RS05490
gene id: 529709:PYCH_RS05490
uniprot id: F8AJ52
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS07715
gene id: 529709:PYCH_RS07715
uniprot id: F8AGV3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

529709:PYCH RS04345
gene id: 529709:PYCH_RS04345
uniprot id: F8AJC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

529709:PYCH RS01420
gene id: 529709:PYCH_RS01420
uniprot id: F8AGM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

529709:PYCH RS00565
gene id: 529709:PYCH_RS00565
uniprot id: F8AFS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

529709:PYCH RS09385
gene id: 529709:PYCH_RS09385
uniprot id: F8AIF9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

529709:PYCH RS08040
gene id: 529709:PYCH_RS08040
uniprot id: F8AH80
names: Subunit
messages: Homotetramer.

529709:PYCH RS03975
gene id: 529709:PYCH_RS03975
uniprot id: F8AJ59
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

529709:PYCH RS04925
gene id: 529709:PYCH_RS04925
uniprot id: F8AEL5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

529709:PYCH RS03680
gene id: 529709:PYCH_RS03680
uniprot id: F8AIW2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

529709:PYCH RS07670
gene id: 529709:PYCH_RS07670
uniprot id: F8AGU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

529709:PYCH RS03330
gene id: 529709:PYCH_RS03330
uniprot id: F8AIK2
names: Similarity
messages: Belongs to the arginase family.

529709:PYCH RS05240
gene id: 529709:PYCH_RS05240
uniprot id: F8AES2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

529709:PYCH RS02895
gene id: 529709:PYCH_RS02895
uniprot id: F8AI52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

529709:PYCH RS01905
gene id: 529709:PYCH_RS01905
uniprot id: F8AH22
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

529709:PYCH RS07120
gene id: 529709:PYCH_RS07120
uniprot id: F8AGC5
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

529709:PYCH RS07625
gene id: 529709:PYCH_RS07625
uniprot id: F8AGT7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

529709:PYCH RS07130
gene id: 529709:PYCH_RS07130
uniprot id: F8AGD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

529709:PYCH RS04525
gene id: 529709:PYCH_RS04525
uniprot id: F8AE96
names: Similarity
messages: Belongs to the UPF0201 family.

529709:PYCH RS07250
gene id: 529709:PYCH_RS07250
uniprot id: F8AGF2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

529709:PYCH RS07180
gene id: 529709:PYCH_RS07180
uniprot id: F8AGE1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

529709:PYCH RS08610
gene id: 529709:PYCH_RS08610
uniprot id: F8AHP1
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS04020
gene id: 529709:PYCH_RS04020
uniprot id: F8AJ68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

529709:PYCH RS01470
gene id: 529709:PYCH_RS01470
uniprot id: F8AIQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

529709:PYCH RS01900
gene id: 529709:PYCH_RS01900
uniprot id: F8AH21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

529709:PYCH RS03980
gene id: 529709:PYCH_RS03980
uniprot id: F8AJ61
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

529709:PYCH RS06875
gene id: 529709:PYCH_RS06875
uniprot id: F8AG15
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

529709:PYCH RS00185
gene id: 529709:PYCH_RS00185
uniprot id: F8AFE7
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

529709:PYCH RS03260
gene id: 529709:PYCH_RS03260
uniprot id: F8AII8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

529709:PYCH RS00495
gene id: 529709:PYCH_RS00495
uniprot id: F8AFR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

529709:PYCH RS03280
gene id: 529709:PYCH_RS03280
uniprot id: F8AIJ2
names: Similarity
messages: Belongs to the class-I fumarase family.

529709:PYCH RS00260
gene id: 529709:PYCH_RS00260
uniprot id: F8AFG4
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

529709:PYCH RS03700
gene id: 529709:PYCH_RS03700
uniprot id: F8AIW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

529709:PYCH RS01240
gene id: 529709:PYCH_RS01240
uniprot id: F8AGB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

529709:PYCH RS05935
gene id: 529709:PYCH_RS05935
uniprot id: F8AF60
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS06575
gene id: 529709:PYCH_RS06575
uniprot id: F8AJE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

529709:PYCH RS08565
gene id: 529709:PYCH_RS08565
uniprot id: F8AHN5
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

529709:PYCH RS03130
gene id: 529709:PYCH_RS03130
uniprot id: F8AIU1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS02515
gene id: 529709:PYCH_RS02515
uniprot id: F8AHR7
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

529709:PYCH RS04150
gene id: 529709:PYCH_RS04150
uniprot id: F8AJ93
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

529709:PYCH RS00350
gene id: 529709:PYCH_RS00350
uniprot id: F8AIH2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

529709:PYCH RS08060
gene id: 529709:PYCH_RS08060
uniprot id: F8AH86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

529709:PYCH RS00760
gene id: 529709:PYCH_RS00760
uniprot id: F8AIP9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

529709:PYCH RS01485
gene id: 529709:PYCH_RS01485
uniprot id: F8AGN4
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

529709:PYCH RS04320
gene id: 529709:PYCH_RS04320
uniprot id: F8AJC0
names: Similarity
messages: Belongs to the glutaredoxin family.

529709:PYCH RS08480
gene id: 529709:PYCH_RS08480
uniprot id: F8AHM0
names: Similarity
messages: Belongs to the UPF0215 family.

529709:PYCH RS06410
gene id: 529709:PYCH_RS06410
uniprot id: F8AFK8
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

529709:PYCH RS01940
gene id: 529709:PYCH_RS01940
uniprot id: F8AH27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

529709:PYCH RS04860
gene id: 529709:PYCH_RS04860
uniprot id: F8AEJ9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

529709:PYCH RS03270
gene id: 529709:PYCH_RS03270
uniprot id: F8AIJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

529709:PYCH RS05010
gene id: 529709:PYCH_RS05010
uniprot id: F8AEN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

529709:PYCH RS06400
gene id: 529709:PYCH_RS06400
uniprot id: F8AFK6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

529709:PYCH RS04535
gene id: 529709:PYCH_RS04535
uniprot id: F8AE98
names: Similarity
messages: Belongs to the UPF0200 family.

529709:PYCH RS04500
gene id: 529709:PYCH_RS04500
uniprot id: F8AE91
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

529709:PYCH RS04180
gene id: 529709:PYCH_RS04180
uniprot id: F8AJ99
names: Similarity
messages: Belongs to the UPF0282 family.

529709:PYCH RS03250
gene id: 529709:PYCH_RS03250
uniprot id: F8AII6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

529709:PYCH RS03420
gene id: 529709:PYCH_RS03420
uniprot id: F8AJ16
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

529709:PYCH RS00705
gene id: 529709:PYCH_RS00705
uniprot id: F8AFV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

529709:PYCH RS00490
gene id: 529709:PYCH_RS00490
uniprot id: F8AFR3
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS04530
gene id: 529709:PYCH_RS04530
uniprot id: F8AE97
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

529709:PYCH RS05405
gene id: 529709:PYCH_RS05405
uniprot id: F8AEV6
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS06585
gene id: 529709:PYCH_RS06585
uniprot id: F8AJE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

529709:PYCH RS02915
gene id: 529709:PYCH_RS02915
uniprot id: F8AI55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

529709:PYCH RS03115
gene id: 529709:PYCH_RS03115
uniprot id: F8AI89
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS05185
gene id: 529709:PYCH_RS05185
uniprot id: F8AER2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

529709:PYCH RS03870
gene id: 529709:PYCH_RS03870
uniprot id: F8AIZ8
names: Similarity
messages: Belongs to the carbamate kinase family.

529709:PYCH RS04140
gene id: 529709:PYCH_RS04140
uniprot id: F8AJ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

529709:PYCH RS08065
gene id: 529709:PYCH_RS08065
uniprot id: F8AEE0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

529709:PYCH RS04540
gene id: 529709:PYCH_RS04540
uniprot id: F8AE99
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

529709:PYCH RS01825
gene id: 529709:PYCH_RS01825
uniprot id: F8AH10
names: Similarity
messages: Belongs to the peptidase U62 family.

529709:PYCH RS00010
gene id: 529709:PYCH_RS00010
uniprot id: F8AF40
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

529709:PYCH RS07100
gene id: 529709:PYCH_RS07100
uniprot id: F8AG56
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

529709:PYCH RS00580
gene id: 529709:PYCH_RS00580
uniprot id: F8AFT1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS03430
gene id: 529709:PYCH_RS03430
uniprot id: F8AIL9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

529709:PYCH RS00955
gene id: 529709:PYCH_RS00955
uniprot id: F8AG72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

529709:PYCH RS04865
gene id: 529709:PYCH_RS04865
uniprot id: F8AEK0
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS02855
gene id: 529709:PYCH_RS02855
uniprot id: F8AI44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS01805
gene id: 529709:PYCH_RS01805
uniprot id: F8AH06
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

529709:PYCH RS07650
gene id: 529709:PYCH_RS07650
uniprot id: F8AGU2
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS01950
gene id: 529709:PYCH_RS01950
uniprot id: F8AH29
names: Similarity
messages: Belongs to the PDCD5 family.

529709:PYCH RS08395
gene id: 529709:PYCH_RS08395
uniprot id: F8AHK3
names: Similarity
messages: Belongs to the UPF0273 family.

529709:PYCH RS07620
gene id: 529709:PYCH_RS07620
uniprot id: F8AGT6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

529709:PYCH RS00445
gene id: 529709:PYCH_RS00445
uniprot id: F8AIP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

529709:PYCH RS05265
gene id: 529709:PYCH_RS05265
uniprot id: F8AES7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS03070
gene id: 529709:PYCH_RS03070
uniprot id: F8AI83
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

529709:PYCH RS00380
gene id: 529709:PYCH_RS00380
uniprot id: F8AIH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

529709:PYCH RS02520
gene id: 529709:PYCH_RS02520
uniprot id: F8AHR8
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS09265
gene id: 529709:PYCH_RS09265
uniprot id: F8AIE4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS09010
gene id: 529709:PYCH_RS09010
uniprot id: F8AI28
names: Similarity
messages: Belongs to the UPF0440 family.

529709:PYCH RS06785
gene id: 529709:PYCH_RS06785
uniprot id: F8AFZ8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

529709:PYCH RS07295
gene id: 529709:PYCH_RS07295
uniprot id: F8AJG4
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

529709:PYCH RS06560
gene id: 529709:PYCH_RS06560
uniprot id: F8AFN5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS02425
gene id: 529709:PYCH_RS02425
uniprot id: F8AHH9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS07330
gene id: 529709:PYCH_RS07330
uniprot id: F8AGG4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

529709:PYCH RS08220
gene id: 529709:PYCH_RS08220
uniprot id: F8AHA4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529709:PYCH RS01465
gene id: 529709:PYCH_RS01465
uniprot id: F8AGN2
names: Similarity
messages: Belongs to the UPF0179 family.

529709:PYCH RS00770
gene id: 529709:PYCH_RS00770
uniprot id: F8AFW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

529709:PYCH RS02890
gene id: 529709:PYCH_RS02890
uniprot id: F8AI51
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

529709:PYCH RS06395
gene id: 529709:PYCH_RS06395
uniprot id: F8AFK5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

529709:PYCH RS01800
gene id: 529709:PYCH_RS01800
uniprot id: F8AH05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

529709:PYCH RS00240
gene id: 529709:PYCH_RS00240
uniprot id: F8AFG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529709:PYCH RS06485
gene id: 529709:PYCH_RS06485
uniprot id: F8AFM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

529709:PYCH RS00430
gene id: 529709:PYCH_RS00430
uniprot id: F8AFI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

529709:PYCH RS01945
gene id: 529709:PYCH_RS01945
uniprot id: F8AH28
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

529709:PYCH RS07895
gene id: 529709:PYCH_RS07895
uniprot id: F8AH49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

529709:PYCH RS03565
gene id: 529709:PYCH_RS03565
uniprot id: F8AIP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

529709:PYCH RS05245
gene id: 529709:PYCH_RS05245
uniprot id: F8AES3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

529709:PYCH RS08585
gene id: 529709:PYCH_RS08585
uniprot id: F8AHN8
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

529709:PYCH RS04695
gene id: 529709:PYCH_RS04695
uniprot id: F8AEC6
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

529709:PYCH RS05485
gene id: 529709:PYCH_RS05485
uniprot id: F8AEW9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS03705
gene id: 529709:PYCH_RS03705
uniprot id: F8AIW7
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

529709:PYCH RS01860
gene id: 529709:PYCH_RS01860
uniprot id: F8AH17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

529709:PYCH RS03120
gene id: 529709:PYCH_RS03120
uniprot id: F8AIU0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS00065
gene id: 529709:PYCH_RS00065
uniprot id: F8AF51
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

529709:PYCH RS03150
gene id: 529709:PYCH_RS03150
uniprot id: F8AI93
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

529709:PYCH RS04710
gene id: 529709:PYCH_RS04710
uniprot id: F8AEC9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

529709:PYCH RS05450
gene id: 529709:PYCH_RS05450
uniprot id: F8AEW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529709:PYCH RS05590
gene id: 529709:PYCH_RS05590
uniprot id: F8AEY8
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

529709:PYCH RS06305
gene id: 529709:PYCH_RS06305
uniprot id: F8AFC1
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

529709:PYCH RS03300
gene id: 529709:PYCH_RS03300
uniprot id: F8AIJ6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

529709:PYCH RS00680
gene id: 529709:PYCH_RS00680
uniprot id: F8AFV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

529709:PYCH RS03855
gene id: 529709:PYCH_RS03855
uniprot id: F8AIZ6
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

529709:PYCH RS03875
gene id: 529709:PYCH_RS03875
uniprot id: F8AJ27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

529709:PYCH RS02355
gene id: 529709:PYCH_RS02355
uniprot id: F8AHG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

529709:PYCH RS09060
gene id: 529709:PYCH_RS09060
uniprot id: F8AI34
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

529709:PYCH RS03190
gene id: 529709:PYCH_RS03190
uniprot id: F8AIA0
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

529709:PYCH RS07665
gene id: 529709:PYCH_RS07665
uniprot id: F8AGU5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

529709:PYCH RS09335
gene id: 529709:PYCH_RS09335
uniprot id: F8AIF4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

529709:PYCH RS07690
gene id: 529709:PYCH_RS07690
uniprot id: F8AGV0
names: Subcellular Location Annotation
messages: Membrane

529709:PYCH RS05820
gene id: 529709:PYCH_RS05820
uniprot id: F8AF25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

529709:PYCH RS09000
gene id: 529709:PYCH_RS09000
uniprot id: F8AI26
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

529709:PYCH RS01195
gene id: 529709:PYCH_RS01195
uniprot id: F8AGB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

529709:PYCH RS07760
gene id: 529709:PYCH_RS07760
uniprot id: F8AJH5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

529709:PYCH RS03955
gene id: 529709:PYCH_RS03955
uniprot id: F8AJ12
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

529709:PYCH RS03305
gene id: 529709:PYCH_RS03305
uniprot id: F8AIJ7
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

529709:PYCH RS07365
gene id: 529709:PYCH_RS07365
uniprot id: F8AGH0
names: Similarity
messages: Belongs to the NOP5/NOP56 family.