523846:MFER RS02175
gene id: 523846:MFER_RS02175
uniprot id: E3GY49
names: Similarity
messages: Belongs to the thymidylate kinase family.

523846:MFER RS04545
gene id: 523846:MFER_RS04545
uniprot id: E3GZF8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

523846:MFER RS02270
gene id: 523846:MFER_RS02270
uniprot id: E3GY69
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

523846:MFER RS04695
gene id: 523846:MFER_RS04695
uniprot id: E3GZI8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523846:MFER RS05325
gene id: 523846:MFER_RS05325
uniprot id: E3GW75
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

523846:MFER RS00540
gene id: 523846:MFER_RS00540
uniprot id: E3GX17
names: Similarity
messages: Belongs to the HypD family.

523846:MFER RS03005
gene id: 523846:MFER_RS03005
uniprot id: E3GYL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

523846:MFER RS04515
gene id: 523846:MFER_RS04515
uniprot id: E3GZF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

523846:MFER RS03790
gene id: 523846:MFER_RS03790
uniprot id: E3GZ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523846:MFER RS02245
gene id: 523846:MFER_RS02245
uniprot id: E3GY64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523846:MFER RS04340
gene id: 523846:MFER_RS04340
uniprot id: E3GZB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

523846:MFER RS01975
gene id: 523846:MFER_RS01975
uniprot id: E3GY12
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523846:MFER RS02575
gene id: 523846:MFER_RS02575
uniprot id: E3GYC5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

523846:MFER RS06795
gene id: 523846:MFER_RS06795
uniprot id: E3GZ95
names: Function
messages: Probably involved in the biogenesis of the ribosome.

523846:MFER RS03045
gene id: 523846:MFER_RS03045
uniprot id: E3GYL8
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

523846:MFER RS04425
gene id: 523846:MFER_RS04425
uniprot id: E3GZD6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

523846:MFER RS01175
gene id: 523846:MFER_RS01175
uniprot id: E3GXK0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

523846:MFER RS04580
gene id: 523846:MFER_RS04580
uniprot id: E3GZG5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

523846:MFER RS00415
gene id: 523846:MFER_RS00415
uniprot id: E3GWZ6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

523846:MFER RS03975
gene id: 523846:MFER_RS03975
uniprot id: E3GZ50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523846:MFER RS00630
gene id: 523846:MFER_RS00630
uniprot id: E3GX36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

523846:MFER RS01965
gene id: 523846:MFER_RS01965
uniprot id: E3GY10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

523846:MFER RS06010
gene id: 523846:MFER_RS06010
uniprot id: E3GWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

523846:MFER RS03275
gene id: 523846:MFER_RS03275
uniprot id: E3GYR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS05705
gene id: 523846:MFER_RS05705
uniprot id: E3GWE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

523846:MFER RS06610
gene id: 523846:MFER_RS06610
uniprot id: E3GX76
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00870
gene id: 523846:MFER_RS00870
uniprot id: E3GXD9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

523846:MFER RS00335
gene id: 523846:MFER_RS00335
uniprot id: E3GWY0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

523846:MFER RS02605
gene id: 523846:MFER_RS02605
uniprot id: E3GYD1
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

523846:MFER RS06310
gene id: 523846:MFER_RS06310
uniprot id: E3GWU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

523846:MFER RS01620
gene id: 523846:MFER_RS01620
uniprot id: E3GXU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

523846:MFER RS05155
gene id: 523846:MFER_RS05155
uniprot id: E3GW45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523846:MFER RS04705
gene id: 523846:MFER_RS04705
uniprot id: E3GZJ0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

523846:MFER RS04975
gene id: 523846:MFER_RS04975
uniprot id: E3GW11
names: Similarity
messages: Belongs to the FwdC/FmdC family.

523846:MFER RS04420
gene id: 523846:MFER_RS04420
uniprot id: E3GZD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

523846:MFER RS00355
gene id: 523846:MFER_RS00355
uniprot id: E3GWY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

523846:MFER RS01395
gene id: 523846:MFER_RS01395
uniprot id: E3GXP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

523846:MFER RS02740
gene id: 523846:MFER_RS02740
uniprot id: E3GYF8
names: Similarity
messages: Belongs to the HerA family.

523846:MFER RS04840
gene id: 523846:MFER_RS04840
uniprot id: E3GVY4
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS01680
gene id: 523846:MFER_RS01680
uniprot id: E3GXV4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

523846:MFER RS03590
gene id: 523846:MFER_RS03590
uniprot id: E3GYX2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

523846:MFER RS04640
gene id: 523846:MFER_RS04640
uniprot id: E3GZH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

523846:MFER RS05850
gene id: 523846:MFER_RS05850
uniprot id: E3GWG1
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

523846:MFER RS04395
gene id: 523846:MFER_RS04395
uniprot id: E3GZD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

523846:MFER RS03940
gene id: 523846:MFER_RS03940
uniprot id: E3GZ43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523846:MFER RS00225
gene id: 523846:MFER_RS00225
uniprot id: E3GWN3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

523846:MFER RS04930
gene id: 523846:MFER_RS04930
uniprot id: E3GW02
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523846:MFER RS02210
gene id: 523846:MFER_RS02210
uniprot id: E3GY56
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS03180
gene id: 523846:MFER_RS03180
uniprot id: E3GYP5
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS03450
gene id: 523846:MFER_RS03450
uniprot id: E3GYU4
names: Similarity
messages: Belongs to the aspartokinase family.

523846:MFER RS03355
gene id: 523846:MFER_RS03355
uniprot id: E3GYS5
names: Similarity
messages: Belongs to the UPF0201 family.

523846:MFER RS01865
gene id: 523846:MFER_RS01865
uniprot id: E3GXZ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

523846:MFER RS00240
gene id: 523846:MFER_RS00240
uniprot id: E3GWN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523846:MFER RS00830
gene id: 523846:MFER_RS00830
uniprot id: E3GXD1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

523846:MFER RS06695
gene id: 523846:MFER_RS06695
uniprot id: E3GX91
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523846:MFER RS06405
gene id: 523846:MFER_RS06405
uniprot id: E3GWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

523846:MFER RS01745
gene id: 523846:MFER_RS01745
uniprot id: E3GXW7
names: Similarity
messages: Belongs to the HMD family.

523846:MFER RS05975
gene id: 523846:MFER_RS05975
uniprot id: E3GWI5
names: Similarity
messages: Belongs to the FwdC/FmdC family.

523846:MFER RS05415
gene id: 523846:MFER_RS05415
uniprot id: E3GW93
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

523846:MFER RS02505
gene id: 523846:MFER_RS02505
uniprot id: E3GYB3
names: Similarity
messages: Belongs to the UPF0107 family.

523846:MFER RS06205
gene id: 523846:MFER_RS06205
uniprot id: E3GWS5
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

523846:MFER RS03100
gene id: 523846:MFER_RS03100
uniprot id: E3GYM9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03840
gene id: 523846:MFER_RS03840
uniprot id: E3GZ22
names: Similarity
messages: Belongs to the CutA family.

523846:MFER RS06640
gene id: 523846:MFER_RS06640
uniprot id: E3GX82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

523846:MFER RS01530
gene id: 523846:MFER_RS01530
uniprot id: E3GXS2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

523846:MFER RS05150
gene id: 523846:MFER_RS05150
uniprot id: E3GW44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

523846:MFER RS04360
gene id: 523846:MFER_RS04360
uniprot id: E3GZC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

523846:MFER RS06435
gene id: 523846:MFER_RS06435
uniprot id: E3GX42
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

523846:MFER RS06555
gene id: 523846:MFER_RS06555
uniprot id: E3GX66
names: Similarity
messages: Belongs to the UDPGP type 2 family.

523846:MFER RS02725
gene id: 523846:MFER_RS02725
uniprot id: E3GYF5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523846:MFER RS04665
gene id: 523846:MFER_RS04665
uniprot id: E3GZI2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS05205
gene id: 523846:MFER_RS05205
uniprot id: E3GW55
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

523846:MFER RS00170
gene id: 523846:MFER_RS00170
uniprot id: E3GWM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

523846:MFER RS03845
gene id: 523846:MFER_RS03845
uniprot id: E3GZ23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS04560
gene id: 523846:MFER_RS04560
uniprot id: E3GZG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS00535
gene id: 523846:MFER_RS00535
uniprot id: E3GX16
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

523846:MFER RS02630
gene id: 523846:MFER_RS02630
uniprot id: E3GYD6
names: Similarity
messages: Belongs to the UPF0280 family.

523846:MFER RS03960
gene id: 523846:MFER_RS03960
uniprot id: E3GZ47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523846:MFER RS01500
gene id: 523846:MFER_RS01500
uniprot id: E3GXR6
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

523846:MFER RS06545
gene id: 523846:MFER_RS06545
uniprot id: E3GX64
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

523846:MFER RS00395
gene id: 523846:MFER_RS00395
uniprot id: O93732
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. It is also able to catalyze the hydrolysis of cDPG but with significant slower rates (8-10 times). May be involved in thermoadaptation.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS04315
gene id: 523846:MFER_RS04315
uniprot id: E3GZB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

523846:MFER RS00425
gene id: 523846:MFER_RS00425
uniprot id: E3GWZ8
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

523846:MFER RS04370
gene id: 523846:MFER_RS04370
uniprot id: E3GZC5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

523846:MFER RS04505
gene id: 523846:MFER_RS04505
uniprot id: E3GZF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS05410
gene id: 523846:MFER_RS05410
uniprot id: E3GW92
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS06030
gene id: 523846:MFER_RS06030
uniprot id: E3GWP1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

523846:MFER RS05760
gene id: 523846:MFER_RS05760
uniprot id: E3GWF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

523846:MFER RS03990
gene id: 523846:MFER_RS03990
uniprot id: E3GZ53
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

523846:MFER RS02350
gene id: 523846:MFER_RS02350
uniprot id: E3GY84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

523846:MFER RS05195
gene id: 523846:MFER_RS05195
uniprot id: E3GW53
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

523846:MFER RS02200
gene id: 523846:MFER_RS02200
uniprot id: E3GY54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

523846:MFER RS04510
gene id: 523846:MFER_RS04510
uniprot id: E3GZF2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523846:MFER RS05620
gene id: 523846:MFER_RS05620
uniprot id: E3GWC5
names: Similarity
messages: Belongs to the FTR family.

523846:MFER RS03760
gene id: 523846:MFER_RS03760
uniprot id: E3GZ06
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

523846:MFER RS00260
gene id: 523846:MFER_RS00260
uniprot id: E3GWW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

523846:MFER RS03475
gene id: 523846:MFER_RS03475
uniprot id: E3GYU9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

523846:MFER RS00775
gene id: 523846:MFER_RS00775
uniprot id: E3GXC2
names: Similarity
messages: Belongs to the HisA/HisF family.

523846:MFER RS02770
gene id: 523846:MFER_RS02770
uniprot id: E3GYG4
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

523846:MFER RS02915
gene id: 523846:MFER_RS02915
uniprot id: E3GYJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

523846:MFER RS01735
gene id: 523846:MFER_RS01735
uniprot id: E3GXW5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

523846:MFER RS06105
gene id: 523846:MFER_RS06105
uniprot id: E3GWQ5
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

523846:MFER RS01300
gene id: 523846:MFER_RS01300
uniprot id: E3GXM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

523846:MFER RS05145
gene id: 523846:MFER_RS05145
uniprot id: E3GW43
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

523846:MFER RS00205
gene id: 523846:MFER_RS00205
uniprot id: E3GWM9
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

523846:MFER RS01840
gene id: 523846:MFER_RS01840
uniprot id: E3GXY5
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00500
gene id: 523846:MFER_RS00500
uniprot id: E3GX10
names: Similarity
messages: Belongs to the TrpF family.

523846:MFER RS04200
gene id: 523846:MFER_RS04200
uniprot id: E3GZ91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

523846:MFER RS03310
gene id: 523846:MFER_RS03310
uniprot id: E3GYS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

523846:MFER RS03040
gene id: 523846:MFER_RS03040
uniprot id: E3GYL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

523846:MFER RS00220
gene id: 523846:MFER_RS00220
uniprot id: E3GWN2
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

523846:MFER RS05020
gene id: 523846:MFER_RS05020
uniprot id: E3GW19
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS06450
gene id: 523846:MFER_RS06450
uniprot id: E3GX45
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

523846:MFER RS04680
gene id: 523846:MFER_RS04680
uniprot id: E3GZI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

523846:MFER RS06195
gene id: 523846:MFER_RS06195
uniprot id: E3GWS3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

523846:MFER RS03345
gene id: 523846:MFER_RS03345
uniprot id: E3GYS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

523846:MFER RS03070
gene id: 523846:MFER_RS03070
uniprot id: E3GYM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

523846:MFER RS03445
gene id: 523846:MFER_RS03445
uniprot id: E3GYU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

523846:MFER RS05860
gene id: 523846:MFER_RS05860
uniprot id: E3GWG3
names: Similarity
messages: Belongs to the UPF0284 family.

523846:MFER RS06255
gene id: 523846:MFER_RS06255
uniprot id: E3GWT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

523846:MFER RS05755
gene id: 523846:MFER_RS05755
uniprot id: E3GWF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

523846:MFER RS06625
gene id: 523846:MFER_RS06625
uniprot id: E3GX79
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS04175
gene id: 523846:MFER_RS04175
uniprot id: E3GZ86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523846:MFER RS06395
gene id: 523846:MFER_RS06395
uniprot id: E3GWW0
names: Similarity
messages: Belongs to the UPF0045 family.

523846:MFER RS04630
gene id: 523846:MFER_RS04630
uniprot id: E3GZH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

523846:MFER RS06165
gene id: 523846:MFER_RS06165
uniprot id: E3GWR7
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

523846:MFER RS03290
gene id: 523846:MFER_RS03290
uniprot id: E3GYR6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

523846:MFER RS03985
gene id: 523846:MFER_RS03985
uniprot id: E3GZ52
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523846:MFER RS05730
gene id: 523846:MFER_RS05730
uniprot id: E3GWE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523846:MFER RS05945
gene id: 523846:MFER_RS05945
uniprot id: E3GWH9
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

523846:MFER RS00030
gene id: 523846:MFER_RS00030
uniprot id: E3GWJ7
names: Similarity
messages: Belongs to the UPF0179 family.

523846:MFER RS00655
gene id: 523846:MFER_RS00655
uniprot id: E3GX98
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

523846:MFER RS01380
gene id: 523846:MFER_RS01380
uniprot id: E3GXP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

523846:MFER RS05000
gene id: 523846:MFER_RS05000
uniprot id: E3GW16
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

523846:MFER RS04895
gene id: 523846:MFER_RS04895
uniprot id: E3GVZ5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

523846:MFER RS03455
gene id: 523846:MFER_RS03455
uniprot id: E3GYU5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

523846:MFER RS06015
gene id: 523846:MFER_RS06015
uniprot id: E3GWN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

523846:MFER RS06425
gene id: 523846:MFER_RS06425
uniprot id: E3GX40
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523846:MFER RS00985
gene id: 523846:MFER_RS00985
uniprot id: E3GXG2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS02305
gene id: 523846:MFER_RS02305
uniprot id: E3GY75
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS04300
gene id: 523846:MFER_RS04300
uniprot id: E3GZB1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

523846:MFER RS00635
gene id: 523846:MFER_RS00635
uniprot id: E3GX94
names: Similarity
messages: Belongs to the class-I fumarase family.

523846:MFER RS06185
gene id: 523846:MFER_RS06185
uniprot id: E3GWS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03425
gene id: 523846:MFER_RS03425
uniprot id: E3GYT9
names: Similarity
messages: Belongs to the citrate synthase family.

523846:MFER RS03065
gene id: 523846:MFER_RS03065
uniprot id: E3GYM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

523846:MFER RS04390
gene id: 523846:MFER_RS04390
uniprot id: E3GZC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

523846:MFER RS02965
gene id: 523846:MFER_RS02965
uniprot id: E3GYK2
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

523846:MFER RS04460
gene id: 523846:MFER_RS04460
uniprot id: E3GZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

523846:MFER RS00265
gene id: 523846:MFER_RS00265
uniprot id: E3GWW6
names: Similarity
messages: Belongs to the GARS family.

523846:MFER RS04590
gene id: 523846:MFER_RS04590
uniprot id: E3GZG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

523846:MFER RS02805
gene id: 523846:MFER_RS02805
uniprot id: E3GYH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

523846:MFER RS03550
gene id: 523846:MFER_RS03550
uniprot id: E3GYW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

523846:MFER RS05300
gene id: 523846:MFER_RS05300
uniprot id: E3GW71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS06680
gene id: 523846:MFER_RS06680
uniprot id: E3GX90
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523846:MFER RS03575
gene id: 523846:MFER_RS03575
uniprot id: E3GYW9
names: Similarity
messages: Belongs to the class-I fumarase family.

523846:MFER RS05550
gene id: 523846:MFER_RS05550
uniprot id: E3GWB2
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS02065
gene id: 523846:MFER_RS02065
uniprot id: E3GY29
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS03300
gene id: 523846:MFER_RS03300
uniprot id: E3GYR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523846:MFER RS05680
gene id: 523846:MFER_RS05680
uniprot id: E3GWD7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

523846:MFER RS02715
gene id: 523846:MFER_RS02715
uniprot id: Q49168
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

523846:MFER RS00725
gene id: 523846:MFER_RS00725
uniprot id: E3GXB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

523846:MFER RS04275
gene id: 523846:MFER_RS04275
uniprot id: E3GZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523846:MFER RS04350
gene id: 523846:MFER_RS04350
uniprot id: E3GZC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

523846:MFER RS01470
gene id: 523846:MFER_RS01470
uniprot id: E3GXQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS05180
gene id: 523846:MFER_RS05180
uniprot id: E3GW50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

523846:MFER RS04400
gene id: 523846:MFER_RS04400
uniprot id: E3GZD1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

523846:MFER RS06095
gene id: 523846:MFER_RS06095
uniprot id: E3GWQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

523846:MFER RS01185
gene id: 523846:MFER_RS01185
uniprot id: E3GXK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

523846:MFER RS03010
gene id: 523846:MFER_RS03010
uniprot id: E3GYL1
names: Similarity
messages: Belongs to the MtxX family.

523846:MFER RS03665
gene id: 523846:MFER_RS03665
uniprot id: E3GYY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

523846:MFER RS01980
gene id: 523846:MFER_RS01980
uniprot id: E3GY13
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

523846:MFER RS00255
gene id: 523846:MFER_RS00255
uniprot id: E3GWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

523846:MFER RS01090
gene id: 523846:MFER_RS01090
uniprot id: E3GXI2
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

523846:MFER RS05280
gene id: 523846:MFER_RS05280
uniprot id: E3GW67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

523846:MFER RS04500
gene id: 523846:MFER_RS04500
uniprot id: E3GZF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

523846:MFER RS04190
gene id: 523846:MFER_RS04190
uniprot id: E3GZ89
names: Similarity
messages: Belongs to the SDO1/SBDS family.

523846:MFER RS01255
gene id: 523846:MFER_RS01255
uniprot id: E3GXL6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

523846:MFER RS00275
gene id: 523846:MFER_RS00275
uniprot id: E3GWW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

523846:MFER RS02470
gene id: 523846:MFER_RS02470
uniprot id: E3GYA6
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

523846:MFER RS01035
gene id: 523846:MFER_RS01035
uniprot id: E3GXH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523846:MFER RS00905
gene id: 523846:MFER_RS00905
uniprot id: E3GXE6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS02560
gene id: 523846:MFER_RS02560
uniprot id: E3GYC2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

523846:MFER RS02195
gene id: 523846:MFER_RS02195
uniprot id: E3GY53
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

523846:MFER RS04335
gene id: 523846:MFER_RS04335
uniprot id: E3GZB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

523846:MFER RS06535
gene id: 523846:MFER_RS06535
uniprot id: E3GX62
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

523846:MFER RS05935
gene id: 523846:MFER_RS05935
uniprot id: E3GWH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

523846:MFER RS01480
gene id: 523846:MFER_RS01480
uniprot id: E3GXR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

523846:MFER RS06170
gene id: 523846:MFER_RS06170
uniprot id: E3GWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

523846:MFER RS04375
gene id: 523846:MFER_RS04375
uniprot id: E3GZC6
names: Similarity
messages: Belongs to the SUI1 family.

523846:MFER RS04025
gene id: 523846:MFER_RS04025
uniprot id: E3GZ60
names: Similarity
messages: Belongs to the UPF0251 family.

523846:MFER RS01420
gene id: 523846:MFER_RS01420
uniprot id: E3GXP9
names: Similarity
messages: Belongs to the AAA ATPase family.

523846:MFER RS01400
gene id: 523846:MFER_RS01400
uniprot id: E3GXP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

523846:MFER RS02900
gene id: 523846:MFER_RS02900
uniprot id: E3GYI9
names: Caution
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03435
gene id: 523846:MFER_RS03435
uniprot id: E3GYU1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS00545
gene id: 523846:MFER_RS00545
uniprot id: E3GX18
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

523846:MFER RS03905
gene id: 523846:MFER_RS03905
uniprot id: E3GZ36
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

523846:MFER RS01265
gene id: 523846:MFER_RS01265
uniprot id: Q49156
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

523846:MFER RS00035
gene id: 523846:MFER_RS00035
uniprot id: E3GWJ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homooctamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03865
gene id: 523846:MFER_RS03865
uniprot id: E3GZ28
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS04530
gene id: 523846:MFER_RS04530
uniprot id: E3GZF6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523846:MFER RS04985
gene id: 523846:MFER_RS04985
uniprot id: E3GW13
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00285
gene id: 523846:MFER_RS00285
uniprot id: E3GWX0
names: Similarity
messages: Belongs to the UPF0285 family.

523846:MFER RS01990
gene id: 523846:MFER_RS01990
uniprot id: E3GY15
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

523846:MFER RS05190
gene id: 523846:MFER_RS05190
uniprot id: E3GW52
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

523846:MFER RS01145
gene id: 523846:MFER_RS01145
uniprot id: E3GXJ3
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

523846:MFER RS04015
gene id: 523846:MFER_RS04015
uniprot id: E3GZ58
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS04415
gene id: 523846:MFER_RS04415
uniprot id: E3GZD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS01940
gene id: 523846:MFER_RS01940
uniprot id: E3GY05
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

523846:MFER RS03410
gene id: 523846:MFER_RS03410
uniprot id: E3GYT6
names: Similarity
messages: Belongs to the PrpD family.

523846:MFER RS04325
gene id: 523846:MFER_RS04325
uniprot id: E3GZB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

523846:MFER RS02565
gene id: 523846:MFER_RS02565
uniprot id: E3GYC3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

523846:MFER RS01365
gene id: 523846:MFER_RS01365
uniprot id: E3GXN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

523846:MFER RS04180
gene id: 523846:MFER_RS04180
uniprot id: E3GZ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523846:MFER RS06585
gene id: 523846:MFER_RS06585
uniprot id: E3GX71
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

523846:MFER RS05350
gene id: 523846:MFER_RS05350
uniprot id: E3GW80
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

523846:MFER RS05030
gene id: 523846:MFER_RS05030
uniprot id: E3GW21
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS03710
gene id: 523846:MFER_RS03710
uniprot id: E3GYZ6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

523846:MFER RS00590
gene id: 523846:MFER_RS00590
uniprot id: E3GX28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

523846:MFER RS04470
gene id: 523846:MFER_RS04470
uniprot id: E3GZE5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

523846:MFER RS06505
gene id: 523846:MFER_RS06505
uniprot id: E3GX56
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523846:MFER RS06215
gene id: 523846:MFER_RS06215
uniprot id: E3GWS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

523846:MFER RS02800
gene id: 523846:MFER_RS02800
uniprot id: E3GYH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

523846:MFER RS06460
gene id: 523846:MFER_RS06460
uniprot id: E3GX47
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

523846:MFER RS00005
gene id: 523846:MFER_RS00005
uniprot id: E3GWJ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS03675
gene id: 523846:MFER_RS03675
uniprot id: E3GYY9
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

523846:MFER RS04980
gene id: 523846:MFER_RS04980
uniprot id: E3GW12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

523846:MFER RS04670
gene id: 523846:MFER_RS04670
uniprot id: E3GZI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

523846:MFER RS00300
gene id: 523846:MFER_RS00300
uniprot id: E3GWX3
names: Similarity
messages: Belongs to the UPF0440 family.

523846:MFER RS00745
gene id: 523846:MFER_RS00745
uniprot id: E3GXB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

523846:MFER RS05135
gene id: 523846:MFER_RS05135
uniprot id: E3GW41
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

523846:MFER RS06700
gene id: 523846:MFER_RS06700
uniprot id: E3GX92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523846:MFER RS03490
gene id: 523846:MFER_RS03490
uniprot id: E3GYV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

523846:MFER RS04550
gene id: 523846:MFER_RS04550
uniprot id: E3GZF9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

523846:MFER RS02335
gene id: 523846:MFER_RS02335
uniprot id: E3GY81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

523846:MFER RS00885
gene id: 523846:MFER_RS00885
uniprot id: E3GXE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS02380
gene id: 523846:MFER_RS02380
uniprot id: E3GY90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS05360
gene id: 523846:MFER_RS05360
uniprot id: E3GW82
names: Similarity
messages: Belongs to the HupF/HypC family.

523846:MFER RS04735
gene id: 523846:MFER_RS04735
uniprot id: E3GZJ7
names: Similarity
messages: Belongs to the UPF0216 family.

523846:MFER RS01065
gene id: 523846:MFER_RS01065
uniprot id: E3GXH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

523846:MFER RS00400
gene id: 523846:MFER_RS00400
uniprot id: E3GWZ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS00865
gene id: 523846:MFER_RS00865
uniprot id: E3GXD8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

523846:MFER RS01105
gene id: 523846:MFER_RS01105
uniprot id: E3GXI5
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS04250
gene id: 523846:MFER_RS04250
uniprot id: E3GZA1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523846:MFER RS04215
gene id: 523846:MFER_RS04215
uniprot id: E3GZ94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523846:MFER RS01410
gene id: 523846:MFER_RS01410
uniprot id: E3GXP7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

523846:MFER RS03015
gene id: 523846:MFER_RS03015
uniprot id: E3GYL2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS02940
gene id: 523846:MFER_RS02940
uniprot id: E3GYJ7
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

523846:MFER RS04900
gene id: 523846:MFER_RS04900
uniprot id: E3GVZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

523846:MFER RS05490
gene id: 523846:MFER_RS05490
uniprot id: E3GWA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

523846:MFER RS00090
gene id: 523846:MFER_RS00090
uniprot id: E3GWL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

523846:MFER RS01845
gene id: 523846:MFER_RS01845
uniprot id: E3GXY6
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS04990
gene id: 523846:MFER_RS04990
uniprot id: E3GW14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523846:MFER RS03895
gene id: 523846:MFER_RS03895
uniprot id: E3GZ34
names: Similarity
messages: Belongs to the UPF0254 family.

523846:MFER RS01460
gene id: 523846:MFER_RS01460
uniprot id: E3GXQ7
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

523846:MFER RS01190
gene id: 523846:MFER_RS01190
uniprot id: E3GXK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

523846:MFER RS02990
gene id: 523846:MFER_RS02990
uniprot id: E3GYK7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

523846:MFER RS01435
gene id: 523846:MFER_RS01435
uniprot id: E3GXQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

523846:MFER RS01780
gene id: 523846:MFER_RS01780
uniprot id: E3GXX4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

523846:MFER RS02960
gene id: 523846:MFER_RS02960
uniprot id: E3GYK1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS00640
gene id: 523846:MFER_RS00640
uniprot id: E3GX95
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

523846:MFER RS03520
gene id: 523846:MFER_RS03520
uniprot id: E3GYV8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523846:MFER RS02655
gene id: 523846:MFER_RS02655
uniprot id: E3GYE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

523846:MFER RS02395
gene id: 523846:MFER_RS02395
uniprot id: E3GY93
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523846:MFER RS01405
gene id: 523846:MFER_RS01405
uniprot id: E3GXP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

523846:MFER RS05710
gene id: 523846:MFER_RS05710
uniprot id: E3GWE2
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00645
gene id: 523846:MFER_RS00645
uniprot id: E3GX96
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

523846:MFER RS00010
gene id: 523846:MFER_RS00010
uniprot id: E3GWJ3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523846:MFER RS04410
gene id: 523846:MFER_RS04410
uniprot id: E3GZD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS01160
gene id: 523846:MFER_RS01160
uniprot id: P27373
names: Function
names: PTM
names: Subcellular Location Annotation
messages: N-glycosylated; contains glycans composed of methyl-Man, Man and GalNAc residues in a molar ratio of 2:3:1.
messages: S-layer
messages: The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of the cell.

523846:MFER RS03240
gene id: 523846:MFER_RS03240
uniprot id: E3GYQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523846:MFER RS05675
gene id: 523846:MFER_RS05675
uniprot id: E3GWD6
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

523846:MFER RS02340
gene id: 523846:MFER_RS02340
uniprot id: E3GY82
names: Similarity
messages: Belongs to the UPF0292 family.

523846:MFER RS01615
gene id: 523846:MFER_RS01615
uniprot id: E3GXT9
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

523846:MFER RS06360
gene id: 523846:MFER_RS06360
uniprot id: E3GWV3
names: Similarity
messages: Belongs to the ComB family.

523846:MFER RS01535
gene id: 523846:MFER_RS01535
uniprot id: E3GXS3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS00490
gene id: 523846:MFER_RS00490
uniprot id: E3GX08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

523846:MFER RS02495
gene id: 523846:MFER_RS02495
uniprot id: E3GYB1
names: Similarity
messages: Belongs to the HMD family.

523846:MFER RS00730
gene id: 523846:MFER_RS00730
uniprot id: E3GXB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

523846:MFER RS00650
gene id: 523846:MFER_RS00650
uniprot id: E3GX97
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

523846:MFER RS04565
gene id: 523846:MFER_RS04565
uniprot id: E3GZG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

523846:MFER RS04440
gene id: 523846:MFER_RS04440
uniprot id: E3GZD9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

523846:MFER RS06210
gene id: 523846:MFER_RS06210
uniprot id: E3GWS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

523846:MFER RS00900
gene id: 523846:MFER_RS00900
uniprot id: E3GXE5
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

523846:MFER RS01000
gene id: 523846:MFER_RS01000
uniprot id: E3GXG5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

523846:MFER RS01915
gene id: 523846:MFER_RS01915
uniprot id: E3GY00
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-99 inactivates the nitrogenase reductase and regulates nitrogenase activity.

523846:MFER RS00235
gene id: 523846:MFER_RS00235
uniprot id: E3GWN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

523846:MFER RS00270
gene id: 523846:MFER_RS00270
uniprot id: E3GWW7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

523846:MFER RS02085
gene id: 523846:MFER_RS02085
uniprot id: E3GY33
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

523846:MFER RS06415
gene id: 523846:MFER_RS06415
uniprot id: E3GX38
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523846:MFER RS04120
gene id: 523846:MFER_RS04120
uniprot id: E3GZ75
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

523846:MFER RS05630
gene id: 523846:MFER_RS05630
uniprot id: E3GWC7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

523846:MFER RS03965
gene id: 523846:MFER_RS03965
uniprot id: E3GZ48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523846:MFER RS00685
gene id: 523846:MFER_RS00685
uniprot id: E3GXA4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

523846:MFER RS04655
gene id: 523846:MFER_RS04655
uniprot id: E3GZI0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS02215
gene id: 523846:MFER_RS02215
uniprot id: E3GY57
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

523846:MFER RS04520
gene id: 523846:MFER_RS04520
uniprot id: E3GZF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

523846:MFER RS02720
gene id: 523846:MFER_RS02720
uniprot id: P56510
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Cell membrane

523846:MFER RS01205
gene id: 523846:MFER_RS01205
uniprot id: E3GXK6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03200
gene id: 523846:MFER_RS03200
uniprot id: E3GYP9
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS06080
gene id: 523846:MFER_RS06080
uniprot id: E3GWQ1
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

523846:MFER RS05365
gene id: 523846:MFER_RS05365
uniprot id: E3GW83
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

523846:MFER RS04230
gene id: 523846:MFER_RS04230
uniprot id: E3GZ97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

523846:MFER RS05170
gene id: 523846:MFER_RS05170
uniprot id: E3GW48
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

523846:MFER RS00920
gene id: 523846:MFER_RS00920
uniprot id: E3GXE9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

523846:MFER RS03085
gene id: 523846:MFER_RS03085
uniprot id: E3GYM6
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS04885
gene id: 523846:MFER_RS04885
uniprot id: E3GVZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

523846:MFER RS02510
gene id: 523846:MFER_RS02510
uniprot id: E3GYB4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

523846:MFER RS00330
gene id: 523846:MFER_RS00330
uniprot id: E3GWX9
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS04210
gene id: 523846:MFER_RS04210
uniprot id: E3GZ93
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523846:MFER RS02255
gene id: 523846:MFER_RS02255
uniprot id: E3GY66
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

523846:MFER RS03685
gene id: 523846:MFER_RS03685
uniprot id: E3GYZ1
names: Similarity
messages: Belongs to the MvhD/VhuD family.

523846:MFER RS03420
gene id: 523846:MFER_RS03420
uniprot id: E3GYT8
names: Similarity
messages: Belongs to the class-I fumarase family.

523846:MFER RS00015
gene id: 523846:MFER_RS00015
uniprot id: E3GWJ4
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

523846:MFER RS03730
gene id: 523846:MFER_RS03730
uniprot id: Q49173
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523846:MFER RS02810
gene id: 523846:MFER_RS02810
uniprot id: E3GYH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

523846:MFER RS01485
gene id: 523846:MFER_RS01485
uniprot id: E3GXR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

523846:MFER RS00880
gene id: 523846:MFER_RS00880
uniprot id: E3GXE1
names: Similarity
messages: Belongs to the PDCD5 family.

523846:MFER RS01440
gene id: 523846:MFER_RS01440
uniprot id: E3GXQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523846:MFER RS06070
gene id: 523846:MFER_RS06070
uniprot id: E3GWP9
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

523846:MFER RS05745
gene id: 523846:MFER_RS05745
uniprot id: E3GWE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

523846:MFER RS04430
gene id: 523846:MFER_RS04430
uniprot id: E3GZD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523846:MFER RS01635
gene id: 523846:MFER_RS01635
uniprot id: E3GXU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

523846:MFER RS05700
gene id: 523846:MFER_RS05700
uniprot id: E3GWE0
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

523846:MFER RS00280
gene id: 523846:MFER_RS00280
uniprot id: E3GWW9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS04000
gene id: 523846:MFER_RS04000
uniprot id: E3GZ55
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523846:MFER RS03160
gene id: 523846:MFER_RS03160
uniprot id: E3GYP1
names: Similarity
messages: Belongs to the TPP enzyme family.

523846:MFER RS02390
gene id: 523846:MFER_RS02390
uniprot id: E3GY92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

523846:MFER RS05335
gene id: 523846:MFER_RS05335
uniprot id: E3GW77
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

523846:MFER RS06020
gene id: 523846:MFER_RS06020
uniprot id: E3GWP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

523846:MFER RS04450
gene id: 523846:MFER_RS04450
uniprot id: E3GZE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523846:MFER RS04380
gene id: 523846:MFER_RS04380
uniprot id: E3GZC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523846:MFER RS03765
gene id: 523846:MFER_RS03765
uniprot id: E3GZ07
names: Similarity
messages: Belongs to the HdrC family.

523846:MFER RS05160
gene id: 523846:MFER_RS05160
uniprot id: E3GW46
names: Similarity
messages: Belongs to the UPF0215 family.

523846:MFER RS06045
gene id: 523846:MFER_RS06045
uniprot id: E3GWP4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03525
gene id: 523846:MFER_RS03525
uniprot id: E3GYV9
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS01830
gene id: 523846:MFER_RS01830
uniprot id: E3GXY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

523846:MFER RS06275
gene id: 523846:MFER_RS06275
uniprot id: E3GWT9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

523846:MFER RS00930
gene id: 523846:MFER_RS00930
uniprot id: E3GXF1
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

523846:MFER RS04045
gene id: 523846:MFER_RS04045
uniprot id: E3GZ64
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS06265
gene id: 523846:MFER_RS06265
uniprot id: E3GWT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

523846:MFER RS03735
gene id: 523846:MFER_RS03735
uniprot id: Q49174
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523846:MFER RS03210
gene id: 523846:MFER_RS03210
uniprot id: E3GYQ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

523846:MFER RS06220
gene id: 523846:MFER_RS06220
uniprot id: E3GWS8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03280
gene id: 523846:MFER_RS03280
uniprot id: E3GYR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

523846:MFER RS06300
gene id: 523846:MFER_RS06300
uniprot id: E3GWU3
names: Similarity
messages: Belongs to the UPF0248 family.

523846:MFER RS02590
gene id: 523846:MFER_RS02590
uniprot id: E3GYC8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

523846:MFER RS05115
gene id: 523846:MFER_RS05115
uniprot id: E3GW37
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

523846:MFER RS02220
gene id: 523846:MFER_RS02220
uniprot id: E3GY58
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

523846:MFER RS05100
gene id: 523846:MFER_RS05100
uniprot id: E3GW34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03215
gene id: 523846:MFER_RS03215
uniprot id: E3GYQ2
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

523846:MFER RS00940
gene id: 523846:MFER_RS00940
uniprot id: E3GXF3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

523846:MFER RS02250
gene id: 523846:MFER_RS02250
uniprot id: E3GY65
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

523846:MFER RS03635
gene id: 523846:MFER_RS03635
uniprot id: E3GYY1
names: Similarity
messages: Belongs to the UPF0173 family.

523846:MFER RS05895
gene id: 523846:MFER_RS05895
uniprot id: E3GWG9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS01135
gene id: 523846:MFER_RS01135
uniprot id: E3GXJ1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS04925
gene id: 523846:MFER_RS04925
uniprot id: E3GW01
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

523846:MFER RS01335
gene id: 523846:MFER_RS01335
uniprot id: E3GXN2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

523846:MFER RS00095
gene id: 523846:MFER_RS00095
uniprot id: E3GWL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

523846:MFER RS02635
gene id: 523846:MFER_RS02635
uniprot id: E3GYD7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

523846:MFER RS00055
gene id: 523846:MFER_RS00055
uniprot id: E3GWK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

523846:MFER RS03670
gene id: 523846:MFER_RS03670
uniprot id: E3GYY8
names: Similarity
messages: Belongs to the UPF0166 family.

523846:MFER RS06620
gene id: 523846:MFER_RS06620
uniprot id: E3GX78
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

523846:MFER RS05070
gene id: 523846:MFER_RS05070
uniprot id: E3GW29
names: Similarity
messages: Belongs to the band 7/mec-2 family.

523846:MFER RS06035
gene id: 523846:MFER_RS06035
uniprot id: E3GWP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523846:MFER RS04385
gene id: 523846:MFER_RS04385
uniprot id: E3GZC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS04145
gene id: 523846:MFER_RS04145
uniprot id: E3GZ80
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

523846:MFER RS03980
gene id: 523846:MFER_RS03980
uniprot id: E3GZ51
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523846:MFER RS04700
gene id: 523846:MFER_RS04700
uniprot id: E3GZI9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

523846:MFER RS04605
gene id: 523846:MFER_RS04605
uniprot id: E3GZH0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

523846:MFER RS05890
gene id: 523846:MFER_RS05890
uniprot id: E3GWG8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

523846:MFER RS00665
gene id: 523846:MFER_RS00665
uniprot id: E3GXA0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

523846:MFER RS03050
gene id: 523846:MFER_RS03050
uniprot id: E3GYL9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

523846:MFER RS04305
gene id: 523846:MFER_RS04305
uniprot id: E3GZB2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

523846:MFER RS00660
gene id: 523846:MFER_RS00660
uniprot id: E3GX99
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

523846:MFER RS04870
gene id: 523846:MFER_RS04870
uniprot id: E3GVZ0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

523846:MFER RS02795
gene id: 523846:MFER_RS02795
uniprot id: E3GYG9
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS03750
gene id: 523846:MFER_RS03750
uniprot id: E3GZ04
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

523846:MFER RS06540
gene id: 523846:MFER_RS06540
uniprot id: E3GX63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

523846:MFER RS06420
gene id: 523846:MFER_RS06420
uniprot id: E3GX39
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523846:MFER RS03485
gene id: 523846:MFER_RS03485
uniprot id: E3GYV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

523846:MFER RS06670
gene id: 523846:MFER_RS06670
uniprot id: E3GX88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

523846:MFER RS02000
gene id: 523846:MFER_RS02000
uniprot id: E3GY17
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

523846:MFER RS00670
gene id: 523846:MFER_RS00670
uniprot id: E3GXA1
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

523846:MFER RS00320
gene id: 523846:MFER_RS00320
uniprot id: E3GWX7
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

523846:MFER RS01875
gene id: 523846:MFER_RS01875
uniprot id: E3GXZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523846:MFER RS05880
gene id: 523846:MFER_RS05880
uniprot id: E3GWG6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

523846:MFER RS03315
gene id: 523846:MFER_RS03315
uniprot id: E3GYS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523846:MFER RS02650
gene id: 523846:MFER_RS02650
uniprot id: E3GYE0
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

523846:MFER RS01590
gene id: 523846:MFER_RS01590
uniprot id: E3GXT4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

523846:MFER RS01570
gene id: 523846:MFER_RS01570
uniprot id: E3GXT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

523846:MFER RS04110
gene id: 523846:MFER_RS04110
uniprot id: E3GZ73
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00845
gene id: 523846:MFER_RS00845
uniprot id: E3GXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

523846:MFER RS04485
gene id: 523846:MFER_RS04485
uniprot id: E3GZE8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

523846:MFER RS04845
gene id: 523846:MFER_RS04845
uniprot id: E3GVY5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

523846:MFER RS06320
gene id: 523846:MFER_RS06320
uniprot id: E3GWU7
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

523846:MFER RS00305
gene id: 523846:MFER_RS00305
uniprot id: E3GWX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

523846:MFER RS00785
gene id: 523846:MFER_RS00785
uniprot id: E3GXC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

523846:MFER RS02300
gene id: 523846:MFER_RS02300
uniprot id: E3GY74
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

523846:MFER RS04525
gene id: 523846:MFER_RS04525
uniprot id: E3GZF5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

523846:MFER RS03495
gene id: 523846:MFER_RS03495
uniprot id: E3GYV3
names: Similarity
messages: Belongs to the UPF0305 family.

523846:MFER RS02365
gene id: 523846:MFER_RS02365
uniprot id: E3GY87
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523846:MFER RS02775
gene id: 523846:MFER_RS02775
uniprot id: E3GYG5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523846:MFER RS01985
gene id: 523846:MFER_RS01985
uniprot id: E3GY14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

523846:MFER RS05965
gene id: 523846:MFER_RS05965
uniprot id: E3GWI3
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS03265
gene id: 523846:MFER_RS03265
uniprot id: E3GYR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

523846:MFER RS01375
gene id: 523846:MFER_RS01375
uniprot id: E3GXP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

523846:MFER RS04435
gene id: 523846:MFER_RS04435
uniprot id: E3GZD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

523846:MFER RS04915
gene id: 523846:MFER_RS04915
uniprot id: E3GVZ9
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

523846:MFER RS04455
gene id: 523846:MFER_RS04455
uniprot id: E3GZE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

523846:MFER RS02955
gene id: 523846:MFER_RS02955
uniprot id: E3GYK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

523846:MFER RS03285
gene id: 523846:MFER_RS03285
uniprot id: E3GYR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

523846:MFER RS06000
gene id: 523846:MFER_RS06000
uniprot id: E3GWJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

523846:MFER RS04075
gene id: 523846:MFER_RS04075
uniprot id: E3GZ66
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

523846:MFER RS00675
gene id: 523846:MFER_RS00675
uniprot id: E3GXA2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

523846:MFER RS04465
gene id: 523846:MFER_RS04465
uniprot id: E3GZE4
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00040
gene id: 523846:MFER_RS00040
uniprot id: E3GWJ9
names: Similarity
messages: Belongs to the NadC/ModD family.

523846:MFER RS04135
gene id: 523846:MFER_RS04135
uniprot id: E3GZ78
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

523846:MFER RS01565
gene id: 523846:MFER_RS01565
uniprot id: E3GXS9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

523846:MFER RS00840
gene id: 523846:MFER_RS00840
uniprot id: E3GXD3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523846:MFER RS03405
gene id: 523846:MFER_RS03405
uniprot id: E3GYT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

523846:MFER RS04090
gene id: 523846:MFER_RS04090
uniprot id: E3GZ69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS01465
gene id: 523846:MFER_RS01465
uniprot id: E3GXQ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

523846:MFER RS01860
gene id: 523846:MFER_RS01860
uniprot id: E3GXY9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523846:MFER RS01725
gene id: 523846:MFER_RS01725
uniprot id: E3GXW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

523846:MFER RS03860
gene id: 523846:MFER_RS03860
uniprot id: E3GZ27
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the small carbamoyl-phosphate synthase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate.

523846:MFER RS04625
gene id: 523846:MFER_RS04625
uniprot id: E3GZH4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

523846:MFER RS05445
gene id: 523846:MFER_RS05445
uniprot id: E3GW94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

523846:MFER RS05980
gene id: 523846:MFER_RS05980
uniprot id: E3GWI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

523846:MFER RS05925
gene id: 523846:MFER_RS05925
uniprot id: E3GWH5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS05120
gene id: 523846:MFER_RS05120
uniprot id: E3GW38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

523846:MFER RS04910
gene id: 523846:MFER_RS04910
uniprot id: E3GVZ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

523846:MFER RS03945
gene id: 523846:MFER_RS03945
uniprot id: E3GZ44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523846:MFER RS05245
gene id: 523846:MFER_RS05245
uniprot id: E3GW62
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

523846:MFER RS03830
gene id: 523846:MFER_RS03830
uniprot id: E3GZ20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

523846:MFER RS03295
gene id: 523846:MFER_RS03295
uniprot id: E3GYR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

523846:MFER RS02710
gene id: 523846:MFER_RS02710
uniprot id: P56509
names: Subcellular Location Annotation
messages: Cell membrane

523846:MFER RS05690
gene id: 523846:MFER_RS05690
uniprot id: E3GWD9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS00850
gene id: 523846:MFER_RS00850
uniprot id: E3GXD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

523846:MFER RS01815
gene id: 523846:MFER_RS01815
uniprot id: E3GXY0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

523846:MFER RS00025
gene id: 523846:MFER_RS00025
uniprot id: E3GWJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

523846:MFER RS01495
gene id: 523846:MFER_RS01495
uniprot id: E3GXR5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

523846:MFER RS03820
gene id: 523846:MFER_RS03820
uniprot id: E3GZ18
names: Similarity
messages: Belongs to the UPF0111 family.

523846:MFER RS05065
gene id: 523846:MFER_RS05065
uniprot id: E3GW28
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00855
gene id: 523846:MFER_RS00855
uniprot id: E3GXD6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

523846:MFER RS01625
gene id: 523846:MFER_RS01625
uniprot id: E3GXU1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

523846:MFER RS05595
gene id: 523846:MFER_RS05595
uniprot id: E3GWC0
names: Similarity
messages: Belongs to the UPF0288 family.

523846:MFER RS01290
gene id: 523846:MFER_RS01290
uniprot id: E3GXM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

523846:MFER RS05005
gene id: 523846:MFER_RS05005
uniprot id: E3GW17
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

523846:MFER RS00200
gene id: 523846:MFER_RS00200
uniprot id: E3GWM8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

523846:MFER RS01630
gene id: 523846:MFER_RS01630
uniprot id: E3GXU2
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

523846:MFER RS06410
gene id: 523846:MFER_RS06410
uniprot id: E3GX37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

523846:MFER RS03055
gene id: 523846:MFER_RS03055
uniprot id: E3GYM0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

523846:MFER RS03725
gene id: 523846:MFER_RS03725
uniprot id: Q49172
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of protein D is not known (By similarity).

523846:MFER RS01200
gene id: 523846:MFER_RS01200
uniprot id: E3GXK5
names: Cofactor
messages: Binds 1 zinc ion per subunit.

523846:MFER RS01520
gene id: 523846:MFER_RS01520
uniprot id: E3GXS0
names: Similarity
messages: Belongs to the UPF0146 family.

523846:MFER RS05400
gene id: 523846:MFER_RS05400
uniprot id: E3GW90
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

523846:MFER RS06135
gene id: 523846:MFER_RS06135
uniprot id: E3GWR1
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

523846:MFER RS00765
gene id: 523846:MFER_RS00765
uniprot id: E3GXC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

523846:MFER RS06175
gene id: 523846:MFER_RS06175
uniprot id: E3GWR9
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

523846:MFER RS06485
gene id: 523846:MFER_RS06485
uniprot id: E3GX52
names: Function
messages: Part of a potassium transport system.

523846:MFER RS05255
gene id: 523846:MFER_RS05255
uniprot id: E3GW64
names: Similarity
messages: Belongs to the FrhG family.

523846:MFER RS02975
gene id: 523846:MFER_RS02975
uniprot id: E3GYK4
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

523846:MFER RS03810
gene id: 523846:MFER_RS03810
uniprot id: E3GZ16
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

523846:MFER RS03060
gene id: 523846:MFER_RS03060
uniprot id: E3GYM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

523846:MFER RS03305
gene id: 523846:MFER_RS03305
uniprot id: E3GYR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523846:MFER RS02580
gene id: 523846:MFER_RS02580
uniprot id: E3GYC6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

523846:MFER RS00970
gene id: 523846:MFER_RS00970
uniprot id: E3GXF9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS04035
gene id: 523846:MFER_RS04035
uniprot id: E3GZ62
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS02265
gene id: 523846:MFER_RS02265
uniprot id: E3GY68
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

523846:MFER RS01060
gene id: 523846:MFER_RS01060
uniprot id: E3GXH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

523846:MFER RS02235
gene id: 523846:MFER_RS02235
uniprot id: E3GY61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

523846:MFER RS00750
gene id: 523846:MFER_RS00750
uniprot id: E3GXB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

523846:MFER RS05095
gene id: 523846:MFER_RS05095
uniprot id: E3GW33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

523846:MFER RS05995
gene id: 523846:MFER_RS05995
uniprot id: E3GWI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

523846:MFER RS01960
gene id: 523846:MFER_RS01960
uniprot id: P16142
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts on oxaloacetate, sulfopyruvate but not on pyruvate. Has a higher selectivity for the coenzyme NADH than for NADPH.
messages: Belongs to the LDH2/MDH2 oxidoreductase family.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS03035
gene id: 523846:MFER_RS03035
uniprot id: E3GYL6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

523846:MFER RS01640
gene id: 523846:MFER_RS01640
uniprot id: E3GXU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

523846:MFER RS01005
gene id: 523846:MFER_RS01005
uniprot id: E3GXG6
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

523846:MFER RS06230
gene id: 523846:MFER_RS06230
uniprot id: E3GWT0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS00570
gene id: 523846:MFER_RS00570
uniprot id: E3GX24
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

523846:MFER RS02020
gene id: 523846:MFER_RS02020
uniprot id: E3GY21
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

523846:MFER RS02475
gene id: 523846:MFER_RS02475
uniprot id: E3GYA7
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

523846:MFER RS02230
gene id: 523846:MFER_RS02230
uniprot id: E3GY60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

523846:MFER RS06440
gene id: 523846:MFER_RS06440
uniprot id: E3GX43
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523846:MFER RS05545
gene id: 523846:MFER_RS05545
uniprot id: E3GWB1
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS06145
gene id: 523846:MFER_RS06145
uniprot id: E3GWR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

523846:MFER RS00065
gene id: 523846:MFER_RS00065
uniprot id: E3GWK4
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00385
gene id: 523846:MFER_RS00385
uniprot id: E3GWZ0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

523846:MFER RS00740
gene id: 523846:MFER_RS00740
uniprot id: E3GXB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

523846:MFER RS00485
gene id: 523846:MFER_RS00485
uniprot id: E3GX07
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS02275
gene id: 523846:MFER_RS02275
uniprot id: E3GY70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

523846:MFER RS04540
gene id: 523846:MFER_RS04540
uniprot id: E3GZF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523846:MFER RS04480
gene id: 523846:MFER_RS04480
uniprot id: E3GZE7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

523846:MFER RS02595
gene id: 523846:MFER_RS02595
uniprot id: E3GYC9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

523846:MFER RS06160
gene id: 523846:MFER_RS06160
uniprot id: E3GWR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

523846:MFER RS00915
gene id: 523846:MFER_RS00915
uniprot id: E3GXE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

523846:MFER RS05670
gene id: 523846:MFER_RS05670
uniprot id: E3GWD5
names: Similarity
messages: Belongs to the glutamate synthase family.

523846:MFER RS01585
gene id: 523846:MFER_RS01585
uniprot id: E3GXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

523846:MFER RS06250
gene id: 523846:MFER_RS06250
uniprot id: E3GWT4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

523846:MFER RS06580
gene id: 523846:MFER_RS06580
uniprot id: E3GX70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

523846:MFER RS02075
gene id: 523846:MFER_RS02075
uniprot id: E3GY31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

523846:MFER RS02640
gene id: 523846:MFER_RS02640
uniprot id: E3GYD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

523846:MFER RS04185
gene id: 523846:MFER_RS04185
uniprot id: E3GZ88
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523846:MFER RS04715
gene id: 523846:MFER_RS04715
uniprot id: E3GZJ2
names: Similarity
messages: Belongs to the UPF0147 family.

523846:MFER RS05290
gene id: 523846:MFER_RS05290
uniprot id: E3GW69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

523846:MFER RS02600
gene id: 523846:MFER_RS02600
uniprot id: E3GYD0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

523846:MFER RS05725
gene id: 523846:MFER_RS05725
uniprot id: E3GWE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

523846:MFER RS02920
gene id: 523846:MFER_RS02920
uniprot id: E3GYJ3
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

523846:MFER RS04995
gene id: 523846:MFER_RS04995
uniprot id: E3GW15
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

523846:MFER RS04225
gene id: 523846:MFER_RS04225
uniprot id: E3GZ96
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

523846:MFER RS05990
gene id: 523846:MFER_RS05990
uniprot id: E3GWI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

523846:MFER RS05955
gene id: 523846:MFER_RS05955
uniprot id: E3GWI1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS02205
gene id: 523846:MFER_RS02205
uniprot id: E3GY55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

523846:MFER RS02485
gene id: 523846:MFER_RS02485
uniprot id: E3GYA9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS03700
gene id: 523846:MFER_RS03700
uniprot id: E3GYZ4
names: Similarity
messages: Belongs to the MvhD/VhuD family.

523846:MFER RS03955
gene id: 523846:MFER_RS03955
uniprot id: E3GZ46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523846:MFER RS00925
gene id: 523846:MFER_RS00925
uniprot id: E3GXF0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

523846:MFER RS04495
gene id: 523846:MFER_RS04495
uniprot id: E3GZE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

523846:MFER RS03720
gene id: 523846:MFER_RS03720
uniprot id: Q49171
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523846:MFER RS05140
gene id: 523846:MFER_RS05140
uniprot id: E3GW42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS00995
gene id: 523846:MFER_RS00995
uniprot id: E3GXG4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

523846:MFER RS04555
gene id: 523846:MFER_RS04555
uniprot id: E3GZG0
names: Similarity
messages: Belongs to the MEMO1 family.

523846:MFER RS01730
gene id: 523846:MFER_RS01730
uniprot id: E3GXW4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS04835
gene id: 523846:MFER_RS04835
uniprot id: E3GVY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

523846:MFER RS05720
gene id: 523846:MFER_RS05720
uniprot id: E3GWE4
names: Caution
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS02665
gene id: 523846:MFER_RS02665
uniprot id: E3GYE3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

523846:MFER RS00945
gene id: 523846:MFER_RS00945
uniprot id: E3GXF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

523846:MFER RS02135
gene id: 523846:MFER_RS02135
uniprot id: E3GY42
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523846:MFER RS06110
gene id: 523846:MFER_RS06110
uniprot id: E3GWQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523846:MFER RS04475
gene id: 523846:MFER_RS04475
uniprot id: E3GZE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

523846:MFER RS04195
gene id: 523846:MFER_RS04195
uniprot id: E3GZ90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

523846:MFER RS01030
gene id: 523846:MFER_RS01030
uniprot id: E3GXH1
names: Similarity
messages: Belongs to the DMRL synthase family.

523846:MFER RS02480
gene id: 523846:MFER_RS02480
uniprot id: E3GYA8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

523846:MFER RS00860
gene id: 523846:MFER_RS00860
uniprot id: E3GXD7
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

523846:MFER RS02260
gene id: 523846:MFER_RS02260
uniprot id: E3GY67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

523846:MFER RS03230
gene id: 523846:MFER_RS03230
uniprot id: E3GYQ5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

523846:MFER RS02185
gene id: 523846:MFER_RS02185
uniprot id: E3GY51
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

523846:MFER RS00625
gene id: 523846:MFER_RS00625
uniprot id: E3GX35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

523846:MFER RS01880
gene id: 523846:MFER_RS01880
uniprot id: E3GXZ3
names: Similarity
messages: Belongs to the UPF0047 family.

523846:MFER RS06295
gene id: 523846:MFER_RS06295
uniprot id: E3GWU2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

523846:MFER RS02675
gene id: 523846:MFER_RS02675
uniprot id: E3GYE5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

523846:MFER RS04575
gene id: 523846:MFER_RS04575
uniprot id: E3GZG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

523846:MFER RS02225
gene id: 523846:MFER_RS02225
uniprot id: E3GY59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

523846:MFER RS03470
gene id: 523846:MFER_RS03470
uniprot id: E3GYU8
names: Similarity
messages: Belongs to the glutaredoxin family.

523846:MFER RS01075
gene id: 523846:MFER_RS01075
uniprot id: E3GXH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

523846:MFER RS06615
gene id: 523846:MFER_RS06615
uniprot id: E3GX77
names: Similarity
messages: Belongs to the HypE family.

523846:MFER RS06705
gene id: 523846:MFER_RS06705
uniprot id: E3GX93
names: Similarity
messages: Belongs to the SAICAR synthetase family.

523846:MFER RS05805
gene id: 523846:MFER_RS05805
uniprot id: E3GWF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

523846:MFER RS05200
gene id: 523846:MFER_RS05200
uniprot id: E3GW54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523846:MFER RS02130
gene id: 523846:MFER_RS02130
uniprot id: E3GY41
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

523846:MFER RS02520
gene id: 523846:MFER_RS02520
uniprot id: E3GYB6
names: Subcellular Location Annotation
messages: Membrane

523846:MFER RS00965
gene id: 523846:MFER_RS00965
uniprot id: E3GXF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523846:MFER RS06970
gene id: 523846:MFER_RS06970
uniprot id: E3GXW0
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

523846:MFER RS00735
gene id: 523846:MFER_RS00735
uniprot id: E3GXB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

523846:MFER RS01895
gene id: 523846:MFER_RS01895
uniprot id: E3GXZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

523846:MFER RS00505
gene id: 523846:MFER_RS00505
uniprot id: E3GX11
names: Similarity
messages: Belongs to the TrpC family.

523846:MFER RS04405
gene id: 523846:MFER_RS04405
uniprot id: E3GZD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

523846:MFER RS03260
gene id: 523846:MFER_RS03260
uniprot id: E3GYR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

523846:MFER RS02610
gene id: 523846:MFER_RS02610
uniprot id: E3GYD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.