521011:MPAL RS07270
gene id: 521011:MPAL_RS07270
uniprot id: B8GI43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS13415
gene id: 521011:MPAL_RS13415
uniprot id: B8GFR7
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02355
gene id: 521011:MPAL_RS02355
uniprot id: B8GKF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

521011:MPAL RS10395
gene id: 521011:MPAL_RS10395
uniprot id: B8GDM9
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

521011:MPAL RS11700
gene id: 521011:MPAL_RS11700
uniprot id: B8GEC6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS11040
gene id: 521011:MPAL_RS11040
uniprot id: B8GE03
names: Similarity
messages: Belongs to the ClpA/ClpB family.

521011:MPAL RS08420
gene id: 521011:MPAL_RS08420
uniprot id: B8GJG1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

521011:MPAL RS00490
gene id: 521011:MPAL_RS00490
uniprot id: B8GID8
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

521011:MPAL RS05320
gene id: 521011:MPAL_RS05320
uniprot id: B8GH05
names: Similarity
messages: Belongs to the UPF0173 family.

521011:MPAL RS10675
gene id: 521011:MPAL_RS10675
uniprot id: B8GDT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

521011:MPAL RS02735
gene id: 521011:MPAL_RS02735
uniprot id: B8GEU7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

521011:MPAL RS13970
gene id: 521011:MPAL_RS13970
uniprot id: B8GGD3
names: Similarity
messages: Belongs to the MoaB/Mog family.

521011:MPAL RS00345
gene id: 521011:MPAL_RS00345
uniprot id: B8GIB0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

521011:MPAL RS11995
gene id: 521011:MPAL_RS11995
uniprot id: B8GEI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

521011:MPAL RS11705
gene id: 521011:MPAL_RS11705
uniprot id: B8GEC7
names: Similarity
messages: Belongs to the UPF0251 family.

521011:MPAL RS13560
gene id: 521011:MPAL_RS13560
uniprot id: B8GFU5
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

521011:MPAL RS02175
gene id: 521011:MPAL_RS02175
uniprot id: B8GKC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

521011:MPAL RS13900
gene id: 521011:MPAL_RS13900
uniprot id: B8GGB8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

521011:MPAL RS08410
gene id: 521011:MPAL_RS08410
uniprot id: B8GJF9
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

521011:MPAL RS02560
gene id: 521011:MPAL_RS02560
uniprot id: B8GKJ6
names: Similarity
messages: Belongs to the UPF0107 family.

521011:MPAL RS05375
gene id: 521011:MPAL_RS05375
uniprot id: B8GH16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS06590
gene id: 521011:MPAL_RS06590
uniprot id: B8GHP1
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

521011:MPAL RS06115
gene id: 521011:MPAL_RS06115
uniprot id: B8GHF5
names: Similarity
messages: Belongs to the HypE family.

521011:MPAL RS00810
gene id: 521011:MPAL_RS00810
uniprot id: B8GIX8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

521011:MPAL RS06480
gene id: 521011:MPAL_RS06480
uniprot id: B8GHM1
names: Similarity
messages: Belongs to the UPF0280 family.

521011:MPAL RS13460
gene id: 521011:MPAL_RS13460
uniprot id: B8GFS6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

521011:MPAL RS05645
gene id: 521011:MPAL_RS05645
uniprot id: B8GH73
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

521011:MPAL RS00015
gene id: 521011:MPAL_RS00015
uniprot id: B8GHS9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS00705
gene id: 521011:MPAL_RS00705
uniprot id: B8GIH9
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

521011:MPAL RS11720
gene id: 521011:MPAL_RS11720
uniprot id: B8GED1
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

521011:MPAL RS04205
gene id: 521011:MPAL_RS04205
uniprot id: B8GGD4
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02040
gene id: 521011:MPAL_RS02040
uniprot id: B8GJX1
names: Similarity
messages: Belongs to the aspartokinase family.

521011:MPAL RS12395
gene id: 521011:MPAL_RS12395
uniprot id: B8GEQ9
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS00600
gene id: 521011:MPAL_RS00600
uniprot id: B8GIF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

521011:MPAL RS07145
gene id: 521011:MPAL_RS07145
uniprot id: B8GI19
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS07140
gene id: 521011:MPAL_RS07140
uniprot id: B8GI18
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

521011:MPAL RS05400
gene id: 521011:MPAL_RS05400
uniprot id: B8GH21
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

521011:MPAL RS13370
gene id: 521011:MPAL_RS13370
uniprot id: B8GFQ7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

521011:MPAL RS04885
gene id: 521011:MPAL_RS04885
uniprot id: B8GGS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

521011:MPAL RS13545
gene id: 521011:MPAL_RS13545
uniprot id: B8GFU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

521011:MPAL RS11875
gene id: 521011:MPAL_RS11875
uniprot id: B8GEF9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

521011:MPAL RS06780
gene id: 521011:MPAL_RS06780
uniprot id: B8GHU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS07665
gene id: 521011:MPAL_RS07665
uniprot id: B8GIP7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

521011:MPAL RS10710
gene id: 521011:MPAL_RS10710
uniprot id: B8GDU0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

521011:MPAL RS09380
gene id: 521011:MPAL_RS09380
uniprot id: B8GKP1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS13760
gene id: 521011:MPAL_RS13760
uniprot id: B8GFY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

521011:MPAL RS11725
gene id: 521011:MPAL_RS11725
uniprot id: B8GED2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

521011:MPAL RS13390
gene id: 521011:MPAL_RS13390
uniprot id: B8GFR1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

521011:MPAL RS09805
gene id: 521011:MPAL_RS09805
uniprot id: B8GKX4
names: Similarity
messages: Belongs to the UPF0111 family.

521011:MPAL RS08340
gene id: 521011:MPAL_RS08340
uniprot id: B8GJE8
names: Similarity
messages: Belongs to the nitroreductase family.

521011:MPAL RS09815
gene id: 521011:MPAL_RS09815
uniprot id: B8GKX5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

521011:MPAL RS01520
gene id: 521011:MPAL_RS01520
uniprot id: B8GJM7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

521011:MPAL RS11780
gene id: 521011:MPAL_RS11780
uniprot id: B8GEE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

521011:MPAL RS05380
gene id: 521011:MPAL_RS05380
uniprot id: B8GH17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521011:MPAL RS11645
gene id: 521011:MPAL_RS11645
uniprot id: B8GEB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

521011:MPAL RS10760
gene id: 521011:MPAL_RS10760
uniprot id: B8GDV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

521011:MPAL RS12040
gene id: 521011:MPAL_RS12040
uniprot id: B8GEJ0
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

521011:MPAL RS03770
gene id: 521011:MPAL_RS03770
uniprot id: B8GG34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

521011:MPAL RS02400
gene id: 521011:MPAL_RS02400
uniprot id: B8GKG6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

521011:MPAL RS08055
gene id: 521011:MPAL_RS08055
uniprot id: B8GJA0
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS00770
gene id: 521011:MPAL_RS00770
uniprot id: B8GIW9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

521011:MPAL RS06530
gene id: 521011:MPAL_RS06530
uniprot id: B8GHN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

521011:MPAL RS12015
gene id: 521011:MPAL_RS12015
uniprot id: B8GEI5
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

521011:MPAL RS09110
gene id: 521011:MPAL_RS09110
uniprot id: B8GK63
names: Subcellular Location Annotation
messages: Cytoplasm

521011:MPAL RS14080
gene id: 521011:MPAL_RS14080
uniprot id: B8GJ77
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS08570
gene id: 521011:MPAL_RS08570
uniprot id: B8GJJ0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

521011:MPAL RS06870
gene id: 521011:MPAL_RS06870
uniprot id: B8GHW4
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS13045
gene id: 521011:MPAL_RS13045
uniprot id: B8GF73
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

521011:MPAL RS09390
gene id: 521011:MPAL_RS09390
uniprot id: B8GKP3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS01145
gene id: 521011:MPAL_RS01145
uniprot id: B8GJ38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

521011:MPAL RS09155
gene id: 521011:MPAL_RS09155
uniprot id: B8GK72
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

521011:MPAL RS03020
gene id: 521011:MPAL_RS03020
uniprot id: B8GFC1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

521011:MPAL RS03635
gene id: 521011:MPAL_RS03635
uniprot id: B8GG11
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS00830
gene id: 521011:MPAL_RS00830
uniprot id: B8GIY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

521011:MPAL RS07670
gene id: 521011:MPAL_RS07670
uniprot id: B8GIP8
names: Similarity
messages: Belongs to the UPF0284 family.

521011:MPAL RS06035
gene id: 521011:MPAL_RS06035
uniprot id: B8GHD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS11575
gene id: 521011:MPAL_RS11575
uniprot id: B8GEA3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

521011:MPAL RS13275
gene id: 521011:MPAL_RS13275
uniprot id: B8GFN8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

521011:MPAL RS06080
gene id: 521011:MPAL_RS06080
uniprot id: B8GHE8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS09640
gene id: 521011:MPAL_RS09640
uniprot id: B8GKU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

521011:MPAL RS13945
gene id: 521011:MPAL_RS13945
uniprot id: B8GGC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS08250
gene id: 521011:MPAL_RS08250
uniprot id: B8GJD9
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02935
gene id: 521011:MPAL_RS02935
uniprot id: B8GFA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

521011:MPAL RS13375
gene id: 521011:MPAL_RS13375
uniprot id: B8GFQ8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

521011:MPAL RS02395
gene id: 521011:MPAL_RS02395
uniprot id: B8GKG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

521011:MPAL RS10825
gene id: 521011:MPAL_RS10825
uniprot id: B8GDW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

521011:MPAL RS07860
gene id: 521011:MPAL_RS07860
uniprot id: B8GIT5
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS08095
gene id: 521011:MPAL_RS08095
uniprot id: B8GJA8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS03025
gene id: 521011:MPAL_RS03025
uniprot id: B8GFC3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

521011:MPAL RS02255
gene id: 521011:MPAL_RS02255
uniprot id: B8GKD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

521011:MPAL RS10870
gene id: 521011:MPAL_RS10870
uniprot id: B8GDX0
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS01040
gene id: 521011:MPAL_RS01040
uniprot id: B8GJ17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

521011:MPAL RS10535
gene id: 521011:MPAL_RS10535
uniprot id: B8GDQ6
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02280
gene id: 521011:MPAL_RS02280
uniprot id: B8GKE0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

521011:MPAL RS13625
gene id: 521011:MPAL_RS13625
uniprot id: B8GFV8
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

521011:MPAL RS04770
gene id: 521011:MPAL_RS04770
uniprot id: B8GGQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

521011:MPAL RS01105
gene id: 521011:MPAL_RS01105
uniprot id: B8GJ30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

521011:MPAL RS04380
gene id: 521011:MPAL_RS04380
uniprot id: B8GGG9
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS04280
gene id: 521011:MPAL_RS04280
uniprot id: B8GGF0
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

521011:MPAL RS05605
gene id: 521011:MPAL_RS05605
uniprot id: B8GH65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS05705
gene id: 521011:MPAL_RS05705
uniprot id: B8GH85
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

521011:MPAL RS08695
gene id: 521011:MPAL_RS08695
uniprot id: B8GJY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

521011:MPAL RS07745
gene id: 521011:MPAL_RS07745
uniprot id: B8GIR3
names: Similarity
messages: Belongs to the AOR/FOR family.

521011:MPAL RS02125
gene id: 521011:MPAL_RS02125
uniprot id: B8GKA9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS13475
gene id: 521011:MPAL_RS13475
uniprot id: B8GFS9
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

521011:MPAL RS02885
gene id: 521011:MPAL_RS02885
uniprot id: B8GEX6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

521011:MPAL RS05370
gene id: 521011:MPAL_RS05370
uniprot id: B8GH15
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

521011:MPAL RS09630
gene id: 521011:MPAL_RS09630
uniprot id: B8GKT9
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12625
gene id: 521011:MPAL_RS12625
uniprot id: B8GEZ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS12790
gene id: 521011:MPAL_RS12790
uniprot id: B8GF23
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

521011:MPAL RS11900
gene id: 521011:MPAL_RS11900
uniprot id: B8GEG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

521011:MPAL RS09975
gene id: 521011:MPAL_RS09975
uniprot id: B8GDF1
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

521011:MPAL RS10940
gene id: 521011:MPAL_RS10940
uniprot id: B8GDY4
names: Similarity
messages: Belongs to the TPP enzyme family.

521011:MPAL RS05460
gene id: 521011:MPAL_RS05460
uniprot id: B8GH33
names: Similarity
messages: Belongs to the HsdR family.

521011:MPAL RS13885
gene id: 521011:MPAL_RS13885
uniprot id: B8GGB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

521011:MPAL RS02410
gene id: 521011:MPAL_RS02410
uniprot id: B8GKG8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

521011:MPAL RS12385
gene id: 521011:MPAL_RS12385
uniprot id: B8GEQ7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

521011:MPAL RS03050
gene id: 521011:MPAL_RS03050
uniprot id: B8GFC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

521011:MPAL RS13695
gene id: 521011:MPAL_RS13695
uniprot id: B8GFX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

521011:MPAL RS05785
gene id: 521011:MPAL_RS05785
uniprot id: B8GHA0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

521011:MPAL RS08480
gene id: 521011:MPAL_RS08480
uniprot id: B8GJH4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

521011:MPAL RS12785
gene id: 521011:MPAL_RS12785
uniprot id: B8GF22
names: Similarity
messages: Belongs to the peptidase C56 family.

521011:MPAL RS02365
gene id: 521011:MPAL_RS02365
uniprot id: B8GKF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

521011:MPAL RS11195
gene id: 521011:MPAL_RS11195
uniprot id: B8GE31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

521011:MPAL RS02350
gene id: 521011:MPAL_RS02350
uniprot id: B8GKF4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

521011:MPAL RS03700
gene id: 521011:MPAL_RS03700
uniprot id: B8GG23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS00055
gene id: 521011:MPAL_RS00055
uniprot id: B8GHT7
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12110
gene id: 521011:MPAL_RS12110
uniprot id: B8GEK4
names: Similarity
messages: Belongs to the UPF0145 family.

521011:MPAL RS11905
gene id: 521011:MPAL_RS11905
uniprot id: B8GEG4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

521011:MPAL RS04275
gene id: 521011:MPAL_RS04275
uniprot id: B8GGE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

521011:MPAL RS11495
gene id: 521011:MPAL_RS11495
uniprot id: B8GE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521011:MPAL RS02875
gene id: 521011:MPAL_RS02875
uniprot id: B8GEX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

521011:MPAL RS11530
gene id: 521011:MPAL_RS11530
uniprot id: B8GE94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

521011:MPAL RS04055
gene id: 521011:MPAL_RS04055
uniprot id: B8GG87
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

521011:MPAL RS01095
gene id: 521011:MPAL_RS01095
uniprot id: B8GJ28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

521011:MPAL RS02370
gene id: 521011:MPAL_RS02370
uniprot id: B8GKF8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS11990
gene id: 521011:MPAL_RS11990
uniprot id: B8GEI0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

521011:MPAL RS02290
gene id: 521011:MPAL_RS02290
uniprot id: B8GKE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS13270
gene id: 521011:MPAL_RS13270
uniprot id: B8GFN7
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

521011:MPAL RS00560
gene id: 521011:MPAL_RS00560
uniprot id: B8GIE9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS10915
gene id: 521011:MPAL_RS10915
uniprot id: B8GDX9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

521011:MPAL RS01430
gene id: 521011:MPAL_RS01430
uniprot id: B8GJL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

521011:MPAL RS08465
gene id: 521011:MPAL_RS08465
uniprot id: B8GJH1
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12295
gene id: 521011:MPAL_RS12295
uniprot id: B8GEP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

521011:MPAL RS03100
gene id: 521011:MPAL_RS03100
uniprot id: B8GFD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

521011:MPAL RS10035
gene id: 521011:MPAL_RS10035
uniprot id: B8GDG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

521011:MPAL RS02710
gene id: 521011:MPAL_RS02710
uniprot id: B8GEU2
names: Similarity
messages: Belongs to the PDCD5 family.

521011:MPAL RS04735
gene id: 521011:MPAL_RS04735
uniprot id: B8GGP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

521011:MPAL RS11640
gene id: 521011:MPAL_RS11640
uniprot id: B8GEB5
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02065
gene id: 521011:MPAL_RS02065
uniprot id: B8GJX6
names: Subcellular Location Annotation
messages: Cytoplasm

521011:MPAL RS09375
gene id: 521011:MPAL_RS09375
uniprot id: B8GKP0
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

521011:MPAL RS05185
gene id: 521011:MPAL_RS05185
uniprot id: B8GGX9
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

521011:MPAL RS11095
gene id: 521011:MPAL_RS11095
uniprot id: B8GE11
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12970
gene id: 521011:MPAL_RS12970
uniprot id: B8GF58
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

521011:MPAL RS03920
gene id: 521011:MPAL_RS03920
uniprot id: B8GG56
names: Similarity
messages: Belongs to the peptidase M3 family.

521011:MPAL RS10630
gene id: 521011:MPAL_RS10630
uniprot id: B8GDS4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS10975
gene id: 521011:MPAL_RS10975
uniprot id: B8GDZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

521011:MPAL RS11105
gene id: 521011:MPAL_RS11105
uniprot id: B8GE13
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02405
gene id: 521011:MPAL_RS02405
uniprot id: B8GKG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

521011:MPAL RS11675
gene id: 521011:MPAL_RS11675
uniprot id: B8GEC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

521011:MPAL RS10510
gene id: 521011:MPAL_RS10510
uniprot id: B8GDQ1
names: Similarity
messages: Belongs to the MCM family.

521011:MPAL RS11610
gene id: 521011:MPAL_RS11610
uniprot id: B8GEA9
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS13225
gene id: 521011:MPAL_RS13225
uniprot id: B8GFM8
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

521011:MPAL RS11870
gene id: 521011:MPAL_RS11870
uniprot id: B8GEF8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

521011:MPAL RS08575
gene id: 521011:MPAL_RS08575
uniprot id: B8GJJ1
names: Similarity
messages: Belongs to the HMBS family.

521011:MPAL RS10815
gene id: 521011:MPAL_RS10815
uniprot id: B8GDV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

521011:MPAL RS02315
gene id: 521011:MPAL_RS02315
uniprot id: B8GKE7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS02010
gene id: 521011:MPAL_RS02010
uniprot id: B8GJW4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

521011:MPAL RS08970
gene id: 521011:MPAL_RS08970
uniprot id: B8GK35
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS07115
gene id: 521011:MPAL_RS07115
uniprot id: B8GI14
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

521011:MPAL RS05965
gene id: 521011:MPAL_RS05965
uniprot id: B8GHC5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

521011:MPAL RS02725
gene id: 521011:MPAL_RS02725
uniprot id: B8GEU5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

521011:MPAL RS00210
gene id: 521011:MPAL_RS00210
uniprot id: B8GI85
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

521011:MPAL RS04760
gene id: 521011:MPAL_RS04760
uniprot id: B8GGQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

521011:MPAL RS11560
gene id: 521011:MPAL_RS11560
uniprot id: B8GEA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

521011:MPAL RS02030
gene id: 521011:MPAL_RS02030
uniprot id: B8GJW9
names: Similarity
messages: Belongs to the ZPR1 family.

521011:MPAL RS02740
gene id: 521011:MPAL_RS02740
uniprot id: B8GEU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

521011:MPAL RS08720
gene id: 521011:MPAL_RS08720
uniprot id: B8GJY8
names: Similarity
messages: Belongs to the UPF0146 family.

521011:MPAL RS10545
gene id: 521011:MPAL_RS10545
uniprot id: B8GDQ8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

521011:MPAL RS13960
gene id: 521011:MPAL_RS13960
uniprot id: B8GGD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

521011:MPAL RS13400
gene id: 521011:MPAL_RS13400
uniprot id: B8GFR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

521011:MPAL RS03420
gene id: 521011:MPAL_RS03420
uniprot id: B8GFJ7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

521011:MPAL RS11100
gene id: 521011:MPAL_RS11100
uniprot id: B8GE12
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS03250
gene id: 521011:MPAL_RS03250
uniprot id: B8GFG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS01865
gene id: 521011:MPAL_RS01865
uniprot id: B8GJT6
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS06130
gene id: 521011:MPAL_RS06130
uniprot id: B8GHF8
names: Function
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

521011:MPAL RS05150
gene id: 521011:MPAL_RS05150
uniprot id: B8GGX2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

521011:MPAL RS04960
gene id: 521011:MPAL_RS04960
uniprot id: B8GGT8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

521011:MPAL RS07755
gene id: 521011:MPAL_RS07755
uniprot id: B8GIR5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

521011:MPAL RS02865
gene id: 521011:MPAL_RS02865
uniprot id: B8GEX2
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

521011:MPAL RS02750
gene id: 521011:MPAL_RS02750
uniprot id: B8GEV0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

521011:MPAL RS02440
gene id: 521011:MPAL_RS02440
uniprot id: B8GKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

521011:MPAL RS10450
gene id: 521011:MPAL_RS10450
uniprot id: B8GDP0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

521011:MPAL RS10390
gene id: 521011:MPAL_RS10390
uniprot id: B8GDM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS00350
gene id: 521011:MPAL_RS00350
uniprot id: B8GIB1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS04775
gene id: 521011:MPAL_RS04775
uniprot id: B8GGQ3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

521011:MPAL RS05095
gene id: 521011:MPAL_RS05095
uniprot id: B8GGW1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

521011:MPAL RS02815
gene id: 521011:MPAL_RS02815
uniprot id: B8GEW3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

521011:MPAL RS03985
gene id: 521011:MPAL_RS03985
uniprot id: B8GG70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

521011:MPAL RS08455
gene id: 521011:MPAL_RS08455
uniprot id: B8GJG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

521011:MPAL RS02785
gene id: 521011:MPAL_RS02785
uniprot id: B8GEV7
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

521011:MPAL RS01665
gene id: 521011:MPAL_RS01665
uniprot id: B8GJQ2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

521011:MPAL RS00260
gene id: 521011:MPAL_RS00260
uniprot id: B8GI94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: Consists of two subunits, CofG and CofH.

521011:MPAL RS11850
gene id: 521011:MPAL_RS11850
uniprot id: B8GEF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS05735
gene id: 521011:MPAL_RS05735
uniprot id: B8GH91
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS00290
gene id: 521011:MPAL_RS00290
uniprot id: B8GIA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

521011:MPAL RS08555
gene id: 521011:MPAL_RS08555
uniprot id: B8GJI7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

521011:MPAL RS08395
gene id: 521011:MPAL_RS08395
uniprot id: B8GJF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

521011:MPAL RS13360
gene id: 521011:MPAL_RS13360
uniprot id: B8GFQ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521011:MPAL RS02250
gene id: 521011:MPAL_RS02250
uniprot id: B8GKD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

521011:MPAL RS13605
gene id: 521011:MPAL_RS13605
uniprot id: B8GFV4
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10640
gene id: 521011:MPAL_RS10640
uniprot id: B8GDS6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS09240
gene id: 521011:MPAL_RS09240
uniprot id: B8GK88
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

521011:MPAL RS00835
gene id: 521011:MPAL_RS00835
uniprot id: B8GIY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

521011:MPAL RS03785
gene id: 521011:MPAL_RS03785
uniprot id: B8GG37
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

521011:MPAL RS03650
gene id: 521011:MPAL_RS03650
uniprot id: B8GG14
names: Similarity
messages: Belongs to the UPF0305 family.

521011:MPAL RS12405
gene id: 521011:MPAL_RS12405
uniprot id: B8GER1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

521011:MPAL RS04670
gene id: 521011:MPAL_RS04670
uniprot id: B8GGN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

521011:MPAL RS00980
gene id: 521011:MPAL_RS00980
uniprot id: B8GJ07
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10565
gene id: 521011:MPAL_RS10565
uniprot id: B8GDR0
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS14285
gene id: 521011:MPAL_RS14285
uniprot id: B8GGR5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

521011:MPAL RS13255
gene id: 521011:MPAL_RS13255
uniprot id: B8GFN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

521011:MPAL RS04025
gene id: 521011:MPAL_RS04025
uniprot id: B8GG80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

521011:MPAL RS10980
gene id: 521011:MPAL_RS10980
uniprot id: B8GDZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

521011:MPAL RS00020
gene id: 521011:MPAL_RS00020
uniprot id: B8GHT0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

521011:MPAL RS09125
gene id: 521011:MPAL_RS09125
uniprot id: B8GK66
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

521011:MPAL RS00355
gene id: 521011:MPAL_RS00355
uniprot id: B8GIB2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

521011:MPAL RS01200
gene id: 521011:MPAL_RS01200
uniprot id: B8GJ47
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

521011:MPAL RS09115
gene id: 521011:MPAL_RS09115
uniprot id: B8GK64
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

521011:MPAL RS10065
gene id: 521011:MPAL_RS10065
uniprot id: B8GDG7
names: Similarity
messages: Belongs to the UPF0285 family.

521011:MPAL RS08850
gene id: 521011:MPAL_RS08850
uniprot id: B8GK14
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

521011:MPAL RS11845
gene id: 521011:MPAL_RS11845
uniprot id: B8GEF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS08080
gene id: 521011:MPAL_RS08080
uniprot id: B8GJA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

521011:MPAL RS09120
gene id: 521011:MPAL_RS09120
uniprot id: B8GK65
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

521011:MPAL RS13140
gene id: 521011:MPAL_RS13140
uniprot id: B8GF90
names: Similarity
messages: Belongs to the Ahb/Nir family.

521011:MPAL RS09360
gene id: 521011:MPAL_RS09360
uniprot id: B8GKN7
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

521011:MPAL RS07705
gene id: 521011:MPAL_RS07705
uniprot id: B8GIQ5
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS01725
gene id: 521011:MPAL_RS01725
uniprot id: B8GJR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

521011:MPAL RS12825
gene id: 521011:MPAL_RS12825
uniprot id: B8GF30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS00825
gene id: 521011:MPAL_RS00825
uniprot id: B8GIY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

521011:MPAL RS04845
gene id: 521011:MPAL_RS04845
uniprot id: B8GGR7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

521011:MPAL RS04665
gene id: 521011:MPAL_RS04665
uniprot id: B8GGN1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

521011:MPAL RS00435
gene id: 521011:MPAL_RS00435
uniprot id: B8GIC7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

521011:MPAL RS03225
gene id: 521011:MPAL_RS03225
uniprot id: B8GFG1
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12955
gene id: 521011:MPAL_RS12955
uniprot id: B8GF54
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

521011:MPAL RS08440
gene id: 521011:MPAL_RS08440
uniprot id: B8GJG6
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

521011:MPAL RS08580
gene id: 521011:MPAL_RS08580
uniprot id: B8GJJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

521011:MPAL RS05780
gene id: 521011:MPAL_RS05780
uniprot id: B8GH99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

521011:MPAL RS11630
gene id: 521011:MPAL_RS11630
uniprot id: B8GEB3
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS00375
gene id: 521011:MPAL_RS00375
uniprot id: B8GIB6
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

521011:MPAL RS06255
gene id: 521011:MPAL_RS06255
uniprot id: B8GHI1
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS03480
gene id: 521011:MPAL_RS03480
uniprot id: B8GFK9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS03255
gene id: 521011:MPAL_RS03255
uniprot id: B8GFG7
names: Similarity
messages: Belongs to the pirin family.

521011:MPAL RS09980
gene id: 521011:MPAL_RS09980
uniprot id: B8GDF2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

521011:MPAL RS06250
gene id: 521011:MPAL_RS06250
uniprot id: B8GHI0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS03530
gene id: 521011:MPAL_RS03530
uniprot id: B8GFL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

521011:MPAL RS03245
gene id: 521011:MPAL_RS03245
uniprot id: B8GFG5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

521011:MPAL RS07460
gene id: 521011:MPAL_RS07460
uniprot id: B8GIK8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS09800
gene id: 521011:MPAL_RS09800
uniprot id: B8GKX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

521011:MPAL RS04780
gene id: 521011:MPAL_RS04780
uniprot id: B8GGQ4
names: Similarity
messages: Belongs to the eIF-2-alpha family.

521011:MPAL RS04890
gene id: 521011:MPAL_RS04890
uniprot id: B8GGS5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

521011:MPAL RS05695
gene id: 521011:MPAL_RS05695
uniprot id: B8GH83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521011:MPAL RS07265
gene id: 521011:MPAL_RS07265
uniprot id: B8GI42
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS07710
gene id: 521011:MPAL_RS07710
uniprot id: B8GIQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS09305
gene id: 521011:MPAL_RS09305
uniprot id: B8GKM6
names: Similarity
messages: Belongs to the pyruvate kinase family.

521011:MPAL RS02880
gene id: 521011:MPAL_RS02880
uniprot id: B8GEX5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

521011:MPAL RS11775
gene id: 521011:MPAL_RS11775
uniprot id: B8GEE1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS02720
gene id: 521011:MPAL_RS02720
uniprot id: B8GEU4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

521011:MPAL RS09725
gene id: 521011:MPAL_RS09725
uniprot id: B8GKW0
names: Similarity
messages: Belongs to the class-I fumarase family.

521011:MPAL RS03775
gene id: 521011:MPAL_RS03775
uniprot id: B8GG35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS02660
gene id: 521011:MPAL_RS02660
uniprot id: B8GKL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

521011:MPAL RS02565
gene id: 521011:MPAL_RS02565
uniprot id: B8GKJ7
names: Similarity
messages: Belongs to the AAA ATPase family.

521011:MPAL RS12655
gene id: 521011:MPAL_RS12655
uniprot id: B8GF04
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

521011:MPAL RS09755
gene id: 521011:MPAL_RS09755
uniprot id: B8GKW5
names: Caution
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS05350
gene id: 521011:MPAL_RS05350
uniprot id: B8GH09
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

521011:MPAL RS08635
gene id: 521011:MPAL_RS08635
uniprot id: B8GJK2
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

521011:MPAL RS06045
gene id: 521011:MPAL_RS06045
uniprot id: B8GHE1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

521011:MPAL RS03010
gene id: 521011:MPAL_RS03010
uniprot id: B8GFB9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

521011:MPAL RS02120
gene id: 521011:MPAL_RS02120
uniprot id: B8GKA8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

521011:MPAL RS11635
gene id: 521011:MPAL_RS11635
uniprot id: B8GEB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

521011:MPAL RS12030
gene id: 521011:MPAL_RS12030
uniprot id: B8GEI8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

521011:MPAL RS02835
gene id: 521011:MPAL_RS02835
uniprot id: B8GEW7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

521011:MPAL RS13725
gene id: 521011:MPAL_RS13725
uniprot id: B8GFX9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

521011:MPAL RS12410
gene id: 521011:MPAL_RS12410
uniprot id: B8GER2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

521011:MPAL RS06160
gene id: 521011:MPAL_RS06160
uniprot id: B8GHG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

521011:MPAL RS13135
gene id: 521011:MPAL_RS13135
uniprot id: B8GF89
names: Similarity
messages: Belongs to the Ahb/Nir family.

521011:MPAL RS13000
gene id: 521011:MPAL_RS13000
uniprot id: B8GF64
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS11140
gene id: 521011:MPAL_RS11140
uniprot id: B8GE20
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS00950
gene id: 521011:MPAL_RS00950
uniprot id: B8GJ02
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS09625
gene id: 521011:MPAL_RS09625
uniprot id: B8GKT8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

521011:MPAL RS14400
gene id: 521011:MPAL_RS14400
uniprot id: B8GHQ6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

521011:MPAL RS09590
gene id: 521011:MPAL_RS09590
uniprot id: B8GKT1
names: Similarity
messages: Belongs to the UPF0305 family.

521011:MPAL RS06635
gene id: 521011:MPAL_RS06635
uniprot id: B8GHP8
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS02330
gene id: 521011:MPAL_RS02330
uniprot id: B8GKF0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

521011:MPAL RS07985
gene id: 521011:MPAL_RS07985
uniprot id: B8GIW4
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

521011:MPAL RS03865
gene id: 521011:MPAL_RS03865
uniprot id: B8GG45
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10805
gene id: 521011:MPAL_RS10805
uniprot id: B8GDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

521011:MPAL RS05390
gene id: 521011:MPAL_RS05390
uniprot id: B8GH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

521011:MPAL RS02635
gene id: 521011:MPAL_RS02635
uniprot id: B8GKL1
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12650
gene id: 521011:MPAL_RS12650
uniprot id: B8GF03
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

521011:MPAL RS02080
gene id: 521011:MPAL_RS02080
uniprot id: B8GKA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

521011:MPAL RS12600
gene id: 521011:MPAL_RS12600
uniprot id: B8GEZ3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

521011:MPAL RS01310
gene id: 521011:MPAL_RS01310
uniprot id: B8GJ69
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

521011:MPAL RS01080
gene id: 521011:MPAL_RS01080
uniprot id: B8GJ25
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS10810
gene id: 521011:MPAL_RS10810
uniprot id: B8GDV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

521011:MPAL RS05600
gene id: 521011:MPAL_RS05600
uniprot id: B8GH64
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02505
gene id: 521011:MPAL_RS02505
uniprot id: B8GKI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

521011:MPAL RS10460
gene id: 521011:MPAL_RS10460
uniprot id: B8GDP2
names: Similarity
messages: Belongs to the peptidase S49 family.

521011:MPAL RS08460
gene id: 521011:MPAL_RS08460
uniprot id: B8GJH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

521011:MPAL RS00925
gene id: 521011:MPAL_RS00925
uniprot id: B8GIZ7
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

521011:MPAL RS05245
gene id: 521011:MPAL_RS05245
uniprot id: B8GGZ0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

521011:MPAL RS13585
gene id: 521011:MPAL_RS13585
uniprot id: B8GFV0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

521011:MPAL RS11985
gene id: 521011:MPAL_RS11985
uniprot id: B8GEH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

521011:MPAL RS10820
gene id: 521011:MPAL_RS10820
uniprot id: B8GDW0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

521011:MPAL RS02780
gene id: 521011:MPAL_RS02780
uniprot id: B8GEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

521011:MPAL RS02015
gene id: 521011:MPAL_RS02015
uniprot id: B8GJW6
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

521011:MPAL RS06520
gene id: 521011:MPAL_RS06520
uniprot id: B8GHM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

521011:MPAL RS02755
gene id: 521011:MPAL_RS02755
uniprot id: B8GEV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

521011:MPAL RS04285
gene id: 521011:MPAL_RS04285
uniprot id: B8GGF1
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

521011:MPAL RS07850
gene id: 521011:MPAL_RS07850
uniprot id: B8GIT3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

521011:MPAL RS12155
gene id: 521011:MPAL_RS12155
uniprot id: B8GEL3
names: Subcellular Location Annotation
messages: Cell membrane

521011:MPAL RS02820
gene id: 521011:MPAL_RS02820
uniprot id: B8GEW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

521011:MPAL RS11865
gene id: 521011:MPAL_RS11865
uniprot id: B8GEF7
names: Similarity
messages: Belongs to the MEMO1 family.

521011:MPAL RS10515
gene id: 521011:MPAL_RS10515
uniprot id: B8GDQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS12670
gene id: 521011:MPAL_RS12670
uniprot id: B8GF07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

521011:MPAL RS09655
gene id: 521011:MPAL_RS09655
uniprot id: B8GKU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS12085
gene id: 521011:MPAL_RS12085
uniprot id: B8GEJ9
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS03055
gene id: 521011:MPAL_RS03055
uniprot id: B8GFC9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

521011:MPAL RS05845
gene id: 521011:MPAL_RS05845
uniprot id: B8GHB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS09840
gene id: 521011:MPAL_RS09840
uniprot id: B8GKY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

521011:MPAL RS03510
gene id: 521011:MPAL_RS03510
uniprot id: B8GFL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

521011:MPAL RS08435
gene id: 521011:MPAL_RS08435
uniprot id: B8GJG5
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

521011:MPAL RS04940
gene id: 521011:MPAL_RS04940
uniprot id: B8GGT4
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10055
gene id: 521011:MPAL_RS10055
uniprot id: B8GDG5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

521011:MPAL RS13240
gene id: 521011:MPAL_RS13240
uniprot id: B8GFN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

521011:MPAL RS09690
gene id: 521011:MPAL_RS09690
uniprot id: B8GKV3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

521011:MPAL RS07960
gene id: 521011:MPAL_RS07960
uniprot id: B8GIV7
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

521011:MPAL RS09545
gene id: 521011:MPAL_RS09545
uniprot id: B8GKS1
names: Similarity
messages: Belongs to the UPF0305 family.

521011:MPAL RS12530
gene id: 521011:MPAL_RS12530
uniprot id: B8GET4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS04875
gene id: 521011:MPAL_RS04875
uniprot id: B8GGS3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: Consists of two subunits, CofG and CofH.

521011:MPAL RS03030
gene id: 521011:MPAL_RS03030
uniprot id: B8GFC4
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

521011:MPAL RS10705
gene id: 521011:MPAL_RS10705
uniprot id: B8GDT9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

521011:MPAL RS11910
gene id: 521011:MPAL_RS11910
uniprot id: B8GEG5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

521011:MPAL RS06500
gene id: 521011:MPAL_RS06500
uniprot id: B8GHM5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

521011:MPAL RS01440
gene id: 521011:MPAL_RS01440
uniprot id: B8GJL2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS08755
gene id: 521011:MPAL_RS08755
uniprot id: B8GJZ5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

521011:MPAL RS11715
gene id: 521011:MPAL_RS11715
uniprot id: B8GED0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

521011:MPAL RS07700
gene id: 521011:MPAL_RS07700
uniprot id: B8GIQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS13385
gene id: 521011:MPAL_RS13385
uniprot id: B8GFR0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

521011:MPAL RS08270
gene id: 521011:MPAL_RS08270
uniprot id: B8GJE3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

521011:MPAL RS08415
gene id: 521011:MPAL_RS08415
uniprot id: B8GJG0
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS11855
gene id: 521011:MPAL_RS11855
uniprot id: B8GEF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

521011:MPAL RS00745
gene id: 521011:MPAL_RS00745
uniprot id: B8GII7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS13085
gene id: 521011:MPAL_RS13085
uniprot id: B8GF79
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

521011:MPAL RS07990
gene id: 521011:MPAL_RS07990
uniprot id: B8GIW5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

521011:MPAL RS02650
gene id: 521011:MPAL_RS02650
uniprot id: B8GKL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

521011:MPAL RS06275
gene id: 521011:MPAL_RS06275
uniprot id: B8GHI5
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS00340
gene id: 521011:MPAL_RS00340
uniprot id: B8GIA9
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS10445
gene id: 521011:MPAL_RS10445
uniprot id: B8GDN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS09255
gene id: 521011:MPAL_RS09255
uniprot id: B8GK91
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

521011:MPAL RS05420
gene id: 521011:MPAL_RS05420
uniprot id: B8GH25
names: Similarity
messages: Belongs to the UPF0212 family.

521011:MPAL RS12885
gene id: 521011:MPAL_RS12885
uniprot id: B8GF42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

521011:MPAL RS05425
gene id: 521011:MPAL_RS05425
uniprot id: B8GH26
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

521011:MPAL RS08470
gene id: 521011:MPAL_RS08470
uniprot id: B8GJH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

521011:MPAL RS11145
gene id: 521011:MPAL_RS11145
uniprot id: B8GE21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

521011:MPAL RS11770
gene id: 521011:MPAL_RS11770
uniprot id: B8GEE0
names: Similarity
messages: Belongs to the GARS family.

521011:MPAL RS02320
gene id: 521011:MPAL_RS02320
uniprot id: B8GKE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS07900
gene id: 521011:MPAL_RS07900
uniprot id: B8GIU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

521011:MPAL RS02325
gene id: 521011:MPAL_RS02325
uniprot id: B8GKE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

521011:MPAL RS01680
gene id: 521011:MPAL_RS01680
uniprot id: B8GJQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

521011:MPAL RS05235
gene id: 521011:MPAL_RS05235
uniprot id: B8GGY8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS07845
gene id: 521011:MPAL_RS07845
uniprot id: B8GIT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS03090
gene id: 521011:MPAL_RS03090
uniprot id: B8GFD6
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

521011:MPAL RS08610
gene id: 521011:MPAL_RS08610
uniprot id: B8GJJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

521011:MPAL RS12700
gene id: 521011:MPAL_RS12700
uniprot id: B8GF12
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

521011:MPAL RS05310
gene id: 521011:MPAL_RS05310
uniprot id: B8GH03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

521011:MPAL RS10525
gene id: 521011:MPAL_RS10525
uniprot id: B8GDQ4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

521011:MPAL RS07680
gene id: 521011:MPAL_RS07680
uniprot id: B8GIQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

521011:MPAL RS06290
gene id: 521011:MPAL_RS06290
uniprot id: B8GHI8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS11375
gene id: 521011:MPAL_RS11375
uniprot id: B8GE64
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

521011:MPAL RS11220
gene id: 521011:MPAL_RS11220
uniprot id: B8GE36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

521011:MPAL RS05790
gene id: 521011:MPAL_RS05790
uniprot id: B8GHA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

521011:MPAL RS00815
gene id: 521011:MPAL_RS00815
uniprot id: B8GIX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

521011:MPAL RS09795
gene id: 521011:MPAL_RS09795
uniprot id: B8GKX2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

521011:MPAL RS06145
gene id: 521011:MPAL_RS06145
uniprot id: B8GHG1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

521011:MPAL RS07360
gene id: 521011:MPAL_RS07360
uniprot id: B8GII9
names: Similarity
messages: Belongs to the UPF0305 family.

521011:MPAL RS11520
gene id: 521011:MPAL_RS11520
uniprot id: B8GE92
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

521011:MPAL RS00335
gene id: 521011:MPAL_RS00335
uniprot id: B8GIA8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

521011:MPAL RS02345
gene id: 521011:MPAL_RS02345
uniprot id: B8GKF3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

521011:MPAL RS11515
gene id: 521011:MPAL_RS11515
uniprot id: B8GE91
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

521011:MPAL RS10090
gene id: 521011:MPAL_RS10090
uniprot id: B8GDH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

521011:MPAL RS03940
gene id: 521011:MPAL_RS03940
uniprot id: B8GG60
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

521011:MPAL RS10025
gene id: 521011:MPAL_RS10025
uniprot id: B8GDF9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

521011:MPAL RS02300
gene id: 521011:MPAL_RS02300
uniprot id: B8GKE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

521011:MPAL RS07620
gene id: 521011:MPAL_RS07620
uniprot id: B8GIN8
names: Similarity
messages: Belongs to the UPF0215 family.

521011:MPAL RS12640
gene id: 521011:MPAL_RS12640
uniprot id: B8GF01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

521011:MPAL RS04870
gene id: 521011:MPAL_RS04870
uniprot id: B8GGS2
names: Similarity
messages: Belongs to the phosphoribulokinase family.

521011:MPAL RS01305
gene id: 521011:MPAL_RS01305
uniprot id: B8GJ68
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

521011:MPAL RS13100
gene id: 521011:MPAL_RS13100
uniprot id: B8GF84
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS13800
gene id: 521011:MPAL_RS13800
uniprot id: B8GFY8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

521011:MPAL RS10005
gene id: 521011:MPAL_RS10005
uniprot id: B8GDF6
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS11500
gene id: 521011:MPAL_RS11500
uniprot id: B8GE88
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS08620
gene id: 521011:MPAL_RS08620
uniprot id: B8GJJ9
names: Similarity
messages: Belongs to the UPF0235 family.

521011:MPAL RS13055
gene id: 521011:MPAL_RS13055
uniprot id: B8GF75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

521011:MPAL RS11570
gene id: 521011:MPAL_RS11570
uniprot id: B8GEA2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

521011:MPAL RS05255
gene id: 521011:MPAL_RS05255
uniprot id: B8GGZ2
names: Similarity
messages: Belongs to the UPF0047 family.

521011:MPAL RS09460
gene id: 521011:MPAL_RS09460
uniprot id: B8GKQ7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

521011:MPAL RS04720
gene id: 521011:MPAL_RS04720
uniprot id: B8GGP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS01325
gene id: 521011:MPAL_RS01325
uniprot id: B8GJ72
names: Similarity
messages: Belongs to the LarC family.

521011:MPAL RS01335
gene id: 521011:MPAL_RS01335
uniprot id: B8GJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS09720
gene id: 521011:MPAL_RS09720
uniprot id: B8GKV9
names: Similarity
messages: Belongs to the class-I fumarase family.

521011:MPAL RS13780
gene id: 521011:MPAL_RS13780
uniprot id: B8GFY5
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

521011:MPAL RS11920
gene id: 521011:MPAL_RS11920
uniprot id: B8GEG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

521011:MPAL RS00590
gene id: 521011:MPAL_RS00590
uniprot id: B8GIF6
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS08680
gene id: 521011:MPAL_RS08680
uniprot id: B8GJY0
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

521011:MPAL RS09550
gene id: 521011:MPAL_RS09550
uniprot id: B8GKS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S33 family.
messages: Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus.
messages: Part of the tricorn proteolytic complex.

521011:MPAL RS02685
gene id: 521011:MPAL_RS02685
uniprot id: B8GKM1
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS03000
gene id: 521011:MPAL_RS03000
uniprot id: B8GFB7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

521011:MPAL RS03995
gene id: 521011:MPAL_RS03995
uniprot id: B8GG73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

521011:MPAL RS04640
gene id: 521011:MPAL_RS04640
uniprot id: B8GGM6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

521011:MPAL RS01475
gene id: 521011:MPAL_RS01475
uniprot id: B8GJL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

521011:MPAL RS11580
gene id: 521011:MPAL_RS11580
uniprot id: B8GEA4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS12805
gene id: 521011:MPAL_RS12805
uniprot id: B8GF26
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS11670
gene id: 521011:MPAL_RS11670
uniprot id: B8GEB9
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

521011:MPAL RS09080
gene id: 521011:MPAL_RS09080
uniprot id: B8GK57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

521011:MPAL RS00145
gene id: 521011:MPAL_RS00145
uniprot id: B8GI74
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

521011:MPAL RS02140
gene id: 521011:MPAL_RS02140
uniprot id: B8GKB2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS02275
gene id: 521011:MPAL_RS02275
uniprot id: B8GKD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS06515
gene id: 521011:MPAL_RS06515
uniprot id: B8GHM8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

521011:MPAL RS02930
gene id: 521011:MPAL_RS02930
uniprot id: B8GFA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

521011:MPAL RS05140
gene id: 521011:MPAL_RS05140
uniprot id: B8GGX0
names: Subunit
messages: Homotetramer.

521011:MPAL RS05100
gene id: 521011:MPAL_RS05100
uniprot id: B8GGW2
names: Similarity
messages: Belongs to the archease family.

521011:MPAL RS11000
gene id: 521011:MPAL_RS11000
uniprot id: B8GDZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

521011:MPAL RS03870
gene id: 521011:MPAL_RS03870
uniprot id: B8GG46
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS00070
gene id: 521011:MPAL_RS00070
uniprot id: B8GHU0
names: Similarity
messages: Belongs to the P(II) protein family.

521011:MPAL RS04050
gene id: 521011:MPAL_RS04050
uniprot id: B8GG86
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS08050
gene id: 521011:MPAL_RS08050
uniprot id: B8GJ99
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS01360
gene id: 521011:MPAL_RS01360
uniprot id: B8GJ79
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS01465
gene id: 521011:MPAL_RS01465
uniprot id: B8GJL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

521011:MPAL RS06270
gene id: 521011:MPAL_RS06270
uniprot id: B8GHI4
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS11525
gene id: 521011:MPAL_RS11525
uniprot id: B8GE93
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

521011:MPAL RS02285
gene id: 521011:MPAL_RS02285
uniprot id: B8GKE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

521011:MPAL RS02745
gene id: 521011:MPAL_RS02745
uniprot id: B8GEU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

521011:MPAL RS12305
gene id: 521011:MPAL_RS12305
uniprot id: B8GEP2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS11860
gene id: 521011:MPAL_RS11860
uniprot id: B8GEF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS01750
gene id: 521011:MPAL_RS01750
uniprot id: B8GJR7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

521011:MPAL RS06685
gene id: 521011:MPAL_RS06685
uniprot id: B8GHQ8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

521011:MPAL RS04045
gene id: 521011:MPAL_RS04045
uniprot id: B8GG85
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Homooctamer; dimer of tetramers.

521011:MPAL RS13295
gene id: 521011:MPAL_RS13295
uniprot id: B8GFP2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS01075
gene id: 521011:MPAL_RS01075
uniprot id: B8GJ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS06135
gene id: 521011:MPAL_RS06135
uniprot id: B8GHF9
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02770
gene id: 521011:MPAL_RS02770
uniprot id: B8GEV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

521011:MPAL RS04850
gene id: 521011:MPAL_RS04850
uniprot id: B8GGR8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS01425
gene id: 521011:MPAL_RS01425
uniprot id: B8GJK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS04130
gene id: 521011:MPAL_RS04130
uniprot id: B8GGA0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

521011:MPAL RS13455
gene id: 521011:MPAL_RS13455
uniprot id: B8GFS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

521011:MPAL RS12675
gene id: 521011:MPAL_RS12675
uniprot id: B8GF08
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

521011:MPAL RS12810
gene id: 521011:MPAL_RS12810
uniprot id: B8GF27
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10310
gene id: 521011:MPAL_RS10310
uniprot id: B8GDL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

521011:MPAL RS03565
gene id: 521011:MPAL_RS03565
uniprot id: B8GFM3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

521011:MPAL RS03335
gene id: 521011:MPAL_RS03335
uniprot id: B8GFI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

521011:MPAL RS00845
gene id: 521011:MPAL_RS00845
uniprot id: B8GIY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

521011:MPAL RS09570
gene id: 521011:MPAL_RS09570
uniprot id: B8GKS6
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS05975
gene id: 521011:MPAL_RS05975
uniprot id: B8GHC7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

521011:MPAL RS09490
gene id: 521011:MPAL_RS09490
uniprot id: B8GKR3
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

521011:MPAL RS08195
gene id: 521011:MPAL_RS08195
uniprot id: B8GJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS13610
gene id: 521011:MPAL_RS13610
uniprot id: B8GFV5
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10305
gene id: 521011:MPAL_RS10305
uniprot id: B8GDL2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

521011:MPAL RS08255
gene id: 521011:MPAL_RS08255
uniprot id: B8GJE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS05515
gene id: 521011:MPAL_RS05515
uniprot id: B8GH46
names: Similarity
messages: Belongs to the UPF0677 family.

521011:MPAL RS01470
gene id: 521011:MPAL_RS01470
uniprot id: B8GJL8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

521011:MPAL RS11915
gene id: 521011:MPAL_RS11915
uniprot id: B8GEG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS02220
gene id: 521011:MPAL_RS02220
uniprot id: B8GKC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

521011:MPAL RS09930
gene id: 521011:MPAL_RS09930
uniprot id: B8GDE2
names: Similarity
messages: Belongs to the SUI1 family.

521011:MPAL RS07165
gene id: 521011:MPAL_RS07165
uniprot id: B8GI23
names: Similarity
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.

521011:MPAL RS00760
gene id: 521011:MPAL_RS00760
uniprot id: B8GIW7
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

521011:MPAL RS01100
gene id: 521011:MPAL_RS01100
uniprot id: B8GJ29
names: Similarity
messages: Belongs to the TrpC family.

521011:MPAL RS08405
gene id: 521011:MPAL_RS08405
uniprot id: B8GJF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

521011:MPAL RS02260
gene id: 521011:MPAL_RS02260
uniprot id: B8GKD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

521011:MPAL RS03215
gene id: 521011:MPAL_RS03215
uniprot id: B8GFF8
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

521011:MPAL RS06050
gene id: 521011:MPAL_RS06050
uniprot id: B8GHE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

521011:MPAL RS01205
gene id: 521011:MPAL_RS01205
uniprot id: B8GJ48
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

521011:MPAL RS10260
gene id: 521011:MPAL_RS10260
uniprot id: B8GDK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS13535
gene id: 521011:MPAL_RS13535
uniprot id: B8GFU0
names: Similarity
messages: Belongs to the glutamate synthase family.

521011:MPAL RS00160
gene id: 521011:MPAL_RS00160
uniprot id: B8GI77
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

521011:MPAL RS09860
gene id: 521011:MPAL_RS09860
uniprot id: B8GKY4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

521011:MPAL RS04460
gene id: 521011:MPAL_RS04460
uniprot id: B8GGI6
names: Similarity
messages: Belongs to the serpin family.

521011:MPAL RS05655
gene id: 521011:MPAL_RS05655
uniprot id: B8GH75
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

521011:MPAL RS03160
gene id: 521011:MPAL_RS03160
uniprot id: B8GFE8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

521011:MPAL RS12575
gene id: 521011:MPAL_RS12575
uniprot id: B8GEY8
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

521011:MPAL RS04030
gene id: 521011:MPAL_RS04030
uniprot id: B8GG81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

521011:MPAL RS01460
gene id: 521011:MPAL_RS01460
uniprot id: B8GJL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

521011:MPAL RS06580
gene id: 521011:MPAL_RS06580
uniprot id: B8GHN9
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

521011:MPAL RS08205
gene id: 521011:MPAL_RS08205
uniprot id: B8GJD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS02305
gene id: 521011:MPAL_RS02305
uniprot id: B8GKE5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

521011:MPAL RS03930
gene id: 521011:MPAL_RS03930
uniprot id: B8GG58
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS01420
gene id: 521011:MPAL_RS01420
uniprot id: B8GJK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

521011:MPAL RS02215
gene id: 521011:MPAL_RS02215
uniprot id: B8GKC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

521011:MPAL RS06235
gene id: 521011:MPAL_RS06235
uniprot id: B8GHH7
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

521011:MPAL RS10465
gene id: 521011:MPAL_RS10465
uniprot id: B8GDP3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

521011:MPAL RS05070
gene id: 521011:MPAL_RS05070
uniprot id: B8GGV6
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

521011:MPAL RS12590
gene id: 521011:MPAL_RS12590
uniprot id: B8GEZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

521011:MPAL RS11650
gene id: 521011:MPAL_RS11650
uniprot id: B8GEB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

521011:MPAL RS05230
gene id: 521011:MPAL_RS05230
uniprot id: B8GGY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

521011:MPAL RS00110
gene id: 521011:MPAL_RS00110
uniprot id: B8GI67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

521011:MPAL RS06260
gene id: 521011:MPAL_RS06260
uniprot id: B8GHI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS08675
gene id: 521011:MPAL_RS08675
uniprot id: B8GJX9
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

521011:MPAL RS13965
gene id: 521011:MPAL_RS13965
uniprot id: B8GGD2
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

521011:MPAL RS09735
gene id: 521011:MPAL_RS09735
uniprot id: B8GKW2
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS04895
gene id: 521011:MPAL_RS04895
uniprot id: B8GGS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

521011:MPAL RS07695
gene id: 521011:MPAL_RS07695
uniprot id: B8GIQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

521011:MPAL RS10715
gene id: 521011:MPAL_RS10715
uniprot id: B8GDU1
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

521011:MPAL RS10440
gene id: 521011:MPAL_RS10440
uniprot id: B8GDN8
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

521011:MPAL RS02340
gene id: 521011:MPAL_RS02340
uniprot id: B8GKF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

521011:MPAL RS02805
gene id: 521011:MPAL_RS02805
uniprot id: B8GEW1
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

521011:MPAL RS03040
gene id: 521011:MPAL_RS03040
uniprot id: B8GFC6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

521011:MPAL RS06040
gene id: 521011:MPAL_RS06040
uniprot id: B8GHE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

521011:MPAL RS07125
gene id: 521011:MPAL_RS07125
uniprot id: B8GI16
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521011:MPAL RS04800
gene id: 521011:MPAL_RS04800
uniprot id: B8GGQ9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

521011:MPAL RS11205
gene id: 521011:MPAL_RS11205
uniprot id: B8GE33
names: Similarity
messages: Belongs to the HdrC family.

521011:MPAL RS11895
gene id: 521011:MPAL_RS11895
uniprot id: B8GEG2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

521011:MPAL RS12400
gene id: 521011:MPAL_RS12400
uniprot id: B8GER0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

521011:MPAL RS13250
gene id: 521011:MPAL_RS13250
uniprot id: B8GFN3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

521011:MPAL RS12540
gene id: 521011:MPAL_RS12540
uniprot id: B8GET6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

521011:MPAL RS11225
gene id: 521011:MPAL_RS11225
uniprot id: B8GE37
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

521011:MPAL RS06730
gene id: 521011:MPAL_RS06730
uniprot id: B8GHR6
names: Subcellular Location Annotation
messages: Cell membrane

521011:MPAL RS04020
gene id: 521011:MPAL_RS04020
uniprot id: B8GG79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

521011:MPAL RS01710
gene id: 521011:MPAL_RS01710
uniprot id: B8GJQ9
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

521011:MPAL RS12620
gene id: 521011:MPAL_RS12620
uniprot id: B8GEZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

521011:MPAL RS01690
gene id: 521011:MPAL_RS01690
uniprot id: B8GJQ7
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

521011:MPAL RS03415
gene id: 521011:MPAL_RS03415
uniprot id: B8GFJ6
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS12845
gene id: 521011:MPAL_RS12845
uniprot id: B8GF34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

521011:MPAL RS04520
gene id: 521011:MPAL_RS04520
uniprot id: B8GGK0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

521011:MPAL RS02465
gene id: 521011:MPAL_RS02465
uniprot id: B8GKH7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

521011:MPAL RS02335
gene id: 521011:MPAL_RS02335
uniprot id: B8GKF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

521011:MPAL RS08670
gene id: 521011:MPAL_RS08670
uniprot id: B8GJX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS05285
gene id: 521011:MPAL_RS05285
uniprot id: B8GGZ8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS06030
gene id: 521011:MPAL_RS06030
uniprot id: B8GHD8
names: Subcellular Location Annotation
messages: Cytoplasm

521011:MPAL RS03035
gene id: 521011:MPAL_RS03035
uniprot id: B8GFC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

521011:MPAL RS01745
gene id: 521011:MPAL_RS01745
uniprot id: B8GJR6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

521011:MPAL RS11550
gene id: 521011:MPAL_RS11550
uniprot id: B8GE98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

521011:MPAL RS00215
gene id: 521011:MPAL_RS00215
uniprot id: B8GI86
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

521011:MPAL RS11840
gene id: 521011:MPAL_RS11840
uniprot id: B8GEF2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

521011:MPAL RS06355
gene id: 521011:MPAL_RS06355
uniprot id: B8GHJ8
names: Similarity
messages: Belongs to the HsdR family.

521011:MPAL RS11175
gene id: 521011:MPAL_RS11175
uniprot id: B8GE27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

521011:MPAL RS03470
gene id: 521011:MPAL_RS03470
uniprot id: B8GFK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS01215
gene id: 521011:MPAL_RS01215
uniprot id: B8GJ50
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10290
gene id: 521011:MPAL_RS10290
uniprot id: B8GDK9
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

521011:MPAL RS08090
gene id: 521011:MPAL_RS08090
uniprot id: B8GJA7
names: Similarity
messages: Belongs to the DtxR/MntR family.

521011:MPAL RS13020
gene id: 521011:MPAL_RS13020
uniprot id: B8GF68
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

521011:MPAL RS10075
gene id: 521011:MPAL_RS10075
uniprot id: B8GDG9
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

521011:MPAL RS03580
gene id: 521011:MPAL_RS03580
uniprot id: B8GG00
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12520
gene id: 521011:MPAL_RS12520
uniprot id: B8GET2
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

521011:MPAL RS02295
gene id: 521011:MPAL_RS02295
uniprot id: B8GKE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

521011:MPAL RS06465
gene id: 521011:MPAL_RS06465
uniprot id: B8GHL8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

521011:MPAL RS03015
gene id: 521011:MPAL_RS03015
uniprot id: B8GFC0
names: Similarity
messages: Belongs to the HAM1 NTPase family.

521011:MPAL RS05115
gene id: 521011:MPAL_RS05115
uniprot id: B8GGW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

521011:MPAL RS00395
gene id: 521011:MPAL_RS00395
uniprot id: B8GIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

521011:MPAL RS00840
gene id: 521011:MPAL_RS00840
uniprot id: B8GIY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

521011:MPAL RS05440
gene id: 521011:MPAL_RS05440
uniprot id: B8GH30
names: Similarity
messages: Belongs to the hemerythrin family.

521011:MPAL RS11200
gene id: 521011:MPAL_RS11200
uniprot id: B8GE32
names: Similarity
messages: Belongs to the HdrB family.

521011:MPAL RS12585
gene id: 521011:MPAL_RS12585
uniprot id: B8GEZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

521011:MPAL RS10935
gene id: 521011:MPAL_RS10935
uniprot id: B8GDY3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

521011:MPAL RS08360
gene id: 521011:MPAL_RS08360
uniprot id: B8GJF1
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS01580
gene id: 521011:MPAL_RS01580
uniprot id: B8GJN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

521011:MPAL RS02165
gene id: 521011:MPAL_RS02165
uniprot id: B8GKB8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02600
gene id: 521011:MPAL_RS02600
uniprot id: B8GKK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

521011:MPAL RS12605
gene id: 521011:MPAL_RS12605
uniprot id: B8GEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

521011:MPAL RS11925
gene id: 521011:MPAL_RS11925
uniprot id: B8GEG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

521011:MPAL RS10985
gene id: 521011:MPAL_RS10985
uniprot id: B8GDZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

521011:MPAL RS04015
gene id: 521011:MPAL_RS04015
uniprot id: B8GG78
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS08520
gene id: 521011:MPAL_RS08520
uniprot id: B8GJI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell.

521011:MPAL RS05075
gene id: 521011:MPAL_RS05075
uniprot id: B8GGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

521011:MPAL RS01340
gene id: 521011:MPAL_RS01340
uniprot id: B8GJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

521011:MPAL RS01295
gene id: 521011:MPAL_RS01295
uniprot id: B8GJ66
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS13940
gene id: 521011:MPAL_RS13940
uniprot id: B8GGC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

521011:MPAL RS09670
gene id: 521011:MPAL_RS09670
uniprot id: B8GKU9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS08100
gene id: 521011:MPAL_RS08100
uniprot id: B8GJA9
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS09750
gene id: 521011:MPAL_RS09750
uniprot id: B8GKW4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

521011:MPAL RS00060
gene id: 521011:MPAL_RS00060
uniprot id: B8GHT8
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

521011:MPAL RS09225
gene id: 521011:MPAL_RS09225
uniprot id: B8GK85
names: Similarity
messages: Belongs to the HypD family.

521011:MPAL RS13030
gene id: 521011:MPAL_RS13030
uniprot id: B8GF70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

521011:MPAL RS02645
gene id: 521011:MPAL_RS02645
uniprot id: B8GKL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

521011:MPAL RS10620
gene id: 521011:MPAL_RS10620
uniprot id: B8GDS2
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

521011:MPAL RS12595
gene id: 521011:MPAL_RS12595
uniprot id: B8GEZ2
names: Similarity
messages: Belongs to the SDO1/SBDS family.

521011:MPAL RS02310
gene id: 521011:MPAL_RS02310
uniprot id: B8GKE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

521011:MPAL RS03895
gene id: 521011:MPAL_RS03895
uniprot id: B8GG50
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS13935
gene id: 521011:MPAL_RS13935
uniprot id: B8GGC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS09685
gene id: 521011:MPAL_RS09685
uniprot id: B8GKV2
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

521011:MPAL RS08510
gene id: 521011:MPAL_RS08510
uniprot id: B8GJH8
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS06545
gene id: 521011:MPAL_RS06545
uniprot id: B8GHN3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

521011:MPAL RS13505
gene id: 521011:MPAL_RS13505
uniprot id: B8GFT4
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10650
gene id: 521011:MPAL_RS10650
uniprot id: B8GDS8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

521011:MPAL RS08450
gene id: 521011:MPAL_RS08450
uniprot id: B8GJG8
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

521011:MPAL RS11765
gene id: 521011:MPAL_RS11765
uniprot id: B8GED9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

521011:MPAL RS08975
gene id: 521011:MPAL_RS08975
uniprot id: B8GK36
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

521011:MPAL RS11890
gene id: 521011:MPAL_RS11890
uniprot id: B8GEG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

521011:MPAL RS10380
gene id: 521011:MPAL_RS10380
uniprot id: B8GDM6
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

521011:MPAL RS08560
gene id: 521011:MPAL_RS08560
uniprot id: B8GJI8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

521011:MPAL RS01625
gene id: 521011:MPAL_RS01625
uniprot id: B8GJP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

521011:MPAL RS07000
gene id: 521011:MPAL_RS07000
uniprot id: B8GHY9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

521011:MPAL RS07840
gene id: 521011:MPAL_RS07840
uniprot id: B8GIT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS01130
gene id: 521011:MPAL_RS01130
uniprot id: B8GJ35
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS13480
gene id: 521011:MPAL_RS13480
uniprot id: B8GFT0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

521011:MPAL RS01565
gene id: 521011:MPAL_RS01565
uniprot id: B8GJN5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

521011:MPAL RS13655
gene id: 521011:MPAL_RS13655
uniprot id: B8GFW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

521011:MPAL RS10410
gene id: 521011:MPAL_RS10410
uniprot id: B8GDN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

521011:MPAL RS12915
gene id: 521011:MPAL_RS12915
uniprot id: B8GF48
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

521011:MPAL RS09075
gene id: 521011:MPAL_RS09075
uniprot id: B8GK56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

521011:MPAL RS12610
gene id: 521011:MPAL_RS12610
uniprot id: B8GEZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

521011:MPAL RS09510
gene id: 521011:MPAL_RS09510
uniprot id: B8GKR6
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12660
gene id: 521011:MPAL_RS12660
uniprot id: B8GF05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

521011:MPAL RS02760
gene id: 521011:MPAL_RS02760
uniprot id: B8GEV2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

521011:MPAL RS12800
gene id: 521011:MPAL_RS12800
uniprot id: B8GF25
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS07930
gene id: 521011:MPAL_RS07930
uniprot id: B8GIV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

521011:MPAL RS09230
gene id: 521011:MPAL_RS09230
uniprot id: B8GK86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

521011:MPAL RS06535
gene id: 521011:MPAL_RS06535
uniprot id: B8GHN2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

521011:MPAL RS09415
gene id: 521011:MPAL_RS09415
uniprot id: B8GKP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

521011:MPAL RS11625
gene id: 521011:MPAL_RS11625
uniprot id: B8GEB2
names: Similarity
messages: Belongs to the DtxR/MntR family.

521011:MPAL RS09935
gene id: 521011:MPAL_RS09935
uniprot id: B8GDE3
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

521011:MPAL RS00200
gene id: 521011:MPAL_RS00200
uniprot id: B8GI83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

521011:MPAL RS11835
gene id: 521011:MPAL_RS11835
uniprot id: B8GEF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

521011:MPAL RS08700
gene id: 521011:MPAL_RS08700
uniprot id: B8GJY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

521011:MPAL RS11025
gene id: 521011:MPAL_RS11025
uniprot id: B8GE01
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

521011:MPAL RS06790
gene id: 521011:MPAL_RS06790
uniprot id: B8GHU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521011:MPAL RS10295
gene id: 521011:MPAL_RS10295
uniprot id: B8GDL0
names: Similarity
messages: Belongs to the HisA/HisF family.

521011:MPAL RS12865
gene id: 521011:MPAL_RS12865
uniprot id: B8GF38
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

521011:MPAL RS13365
gene id: 521011:MPAL_RS13365
uniprot id: B8GFQ6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

521011:MPAL RS08640
gene id: 521011:MPAL_RS08640
uniprot id: B8GJK3
names: Similarity
messages: Belongs to the HupF/HypC family.

521011:MPAL RS01610
gene id: 521011:MPAL_RS01610
uniprot id: B8GJP3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

521011:MPAL RS01230
gene id: 521011:MPAL_RS01230
uniprot id: B8GJ53
names: Similarity
messages: Belongs to the malic enzymes family.

521011:MPAL RS00460
gene id: 521011:MPAL_RS00460
uniprot id: B8GID2
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10300
gene id: 521011:MPAL_RS10300
uniprot id: B8GDL1
names: Similarity
messages: Belongs to the thymidylate kinase family.

521011:MPAL RS06525
gene id: 521011:MPAL_RS06525
uniprot id: B8GHN0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

521011:MPAL RS07770
gene id: 521011:MPAL_RS07770
uniprot id: B8GIR8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS03140
gene id: 521011:MPAL_RS03140
uniprot id: B8GFE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

521011:MPAL RS07505
gene id: 521011:MPAL_RS07505
uniprot id: B8GIL6
names: Similarity
messages: Belongs to the HerA family.

521011:MPAL RS04755
gene id: 521011:MPAL_RS04755
uniprot id: B8GGP9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

521011:MPAL RS11685
gene id: 521011:MPAL_RS11685
uniprot id: B8GEC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

521011:MPAL RS07600
gene id: 521011:MPAL_RS07600
uniprot id: B8GIN4
names: Similarity
messages: Belongs to the UPF0677 family.

521011:MPAL RS11505
gene id: 521011:MPAL_RS11505
uniprot id: B8GE89
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

521011:MPAL RS02170
gene id: 521011:MPAL_RS02170
uniprot id: B8GKB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS02435
gene id: 521011:MPAL_RS02435
uniprot id: B8GKH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS00105
gene id: 521011:MPAL_RS00105
uniprot id: B8GI66
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS11880
gene id: 521011:MPAL_RS11880
uniprot id: B8GEG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

521011:MPAL RS00195
gene id: 521011:MPAL_RS00195
uniprot id: B8GI82
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

521011:MPAL RS01555
gene id: 521011:MPAL_RS01555
uniprot id: B8GJN3
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

521011:MPAL RS06455
gene id: 521011:MPAL_RS06455
uniprot id: B8GHL6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

521011:MPAL RS08515
gene id: 521011:MPAL_RS08515
uniprot id: B8GJH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

521011:MPAL RS02245
gene id: 521011:MPAL_RS02245
uniprot id: B8GKD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

521011:MPAL RS10085
gene id: 521011:MPAL_RS10085
uniprot id: B8GDH1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

521011:MPAL RS05590
gene id: 521011:MPAL_RS05590
uniprot id: B8GH62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

521011:MPAL RS00820
gene id: 521011:MPAL_RS00820
uniprot id: B8GIY0
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS13915
gene id: 521011:MPAL_RS13915
uniprot id: B8GGC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS13450
gene id: 521011:MPAL_RS13450
uniprot id: B8GFS4
names: Similarity
messages: Belongs to the peptidase U62 family.

521011:MPAL RS11415
gene id: 521011:MPAL_RS11415
uniprot id: B8GE68
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

521011:MPAL RS00150
gene id: 521011:MPAL_RS00150
uniprot id: B8GI75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

521011:MPAL RS13465
gene id: 521011:MPAL_RS13465
uniprot id: B8GFS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

521011:MPAL RS01090
gene id: 521011:MPAL_RS01090
uniprot id: B8GJ27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

521011:MPAL RS02375
gene id: 521011:MPAL_RS02375
uniprot id: B8GKF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

521011:MPAL RS03755
gene id: 521011:MPAL_RS03755
uniprot id: B8GG31
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

521011:MPAL RS10580
gene id: 521011:MPAL_RS10580
uniprot id: B8GDR3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS07980
gene id: 521011:MPAL_RS07980
uniprot id: B8GIW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

521011:MPAL RS10435
gene id: 521011:MPAL_RS10435
uniprot id: B8GDN7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

521011:MPAL RS10505
gene id: 521011:MPAL_RS10505
uniprot id: B8GDQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

521011:MPAL RS12830
gene id: 521011:MPAL_RS12830
uniprot id: B8GF31
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

521011:MPAL RS06435
gene id: 521011:MPAL_RS06435
uniprot id: B8GHL2
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

521011:MPAL RS02550
gene id: 521011:MPAL_RS02550
uniprot id: B8GKJ4
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

521011:MPAL RS06505
gene id: 521011:MPAL_RS06505
uniprot id: B8GHM6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

521011:MPAL RS08590
gene id: 521011:MPAL_RS08590
uniprot id: B8GJJ4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

521011:MPAL RS01600
gene id: 521011:MPAL_RS01600
uniprot id: B8GJP1
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

521011:MPAL RS10540
gene id: 521011:MPAL_RS10540
uniprot id: B8GDQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

521011:MPAL RS08240
gene id: 521011:MPAL_RS08240
uniprot id: B8GJD7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

521011:MPAL RS10855
gene id: 521011:MPAL_RS10855
uniprot id: B8GDW7
names: Similarity
messages: Belongs to the Nth/MutY family.

521011:MPAL RS07135
gene id: 521011:MPAL_RS07135
uniprot id: B8GI17
names: Similarity
messages: Belongs to the phosphohexose mutase family.

521011:MPAL RS10485
gene id: 521011:MPAL_RS10485
uniprot id: B8GDP6
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS00430
gene id: 521011:MPAL_RS00430
uniprot id: B8GIC6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

521011:MPAL RS13925
gene id: 521011:MPAL_RS13925
uniprot id: B8GGC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

521011:MPAL RS02655
gene id: 521011:MPAL_RS02655
uniprot id: B8GKL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

521011:MPAL RS01595
gene id: 521011:MPAL_RS01595
uniprot id: B8GJP0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

521011:MPAL RS10385
gene id: 521011:MPAL_RS10385
uniprot id: B8GDM7
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

521011:MPAL RS03350
gene id: 521011:MPAL_RS03350
uniprot id: B8GFI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

521011:MPAL RS05295
gene id: 521011:MPAL_RS05295
uniprot id: B8GH00
names: Similarity
messages: Belongs to the UPF0147 family.

521011:MPAL RS02555
gene id: 521011:MPAL_RS02555
uniprot id: B8GKJ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS00710
gene id: 521011:MPAL_RS00710
uniprot id: B8GII0
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

521011:MPAL RS06785
gene id: 521011:MPAL_RS06785
uniprot id: B8GHU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521011:MPAL RS12960
gene id: 521011:MPAL_RS12960
uniprot id: B8GF55
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

521011:MPAL RS01735
gene id: 521011:MPAL_RS01735
uniprot id: B8GJR4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS02730
gene id: 521011:MPAL_RS02730
uniprot id: B8GEU6
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

521011:MPAL RS02575
gene id: 521011:MPAL_RS02575
uniprot id: B8GKJ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS00855
gene id: 521011:MPAL_RS00855
uniprot id: B8GIY7
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS02620
gene id: 521011:MPAL_RS02620
uniprot id: B8GKK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

521011:MPAL RS01605
gene id: 521011:MPAL_RS01605
uniprot id: B8GJP2
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

521011:MPAL RS07785
gene id: 521011:MPAL_RS07785
uniprot id: B8GIS1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

521011:MPAL RS02360
gene id: 521011:MPAL_RS02360
uniprot id: B8GKF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

521011:MPAL RS13380
gene id: 521011:MPAL_RS13380
uniprot id: B8GFQ9
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

521011:MPAL RS00890
gene id: 521011:MPAL_RS00890
uniprot id: B8GIZ3
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS12310
gene id: 521011:MPAL_RS12310
uniprot id: B8GEP3
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS00225
gene id: 521011:MPAL_RS00225
uniprot id: B8GI89
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS10285
gene id: 521011:MPAL_RS10285
uniprot id: B8GDK8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

521011:MPAL RS02870
gene id: 521011:MPAL_RS02870
uniprot id: B8GEX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

521011:MPAL RS00365
gene id: 521011:MPAL_RS00365
uniprot id: B8GIB4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

521011:MPAL RS12185
gene id: 521011:MPAL_RS12185
uniprot id: B8GEL9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

521011:MPAL RS05765
gene id: 521011:MPAL_RS05765
uniprot id: B8GH96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521011:MPAL RS04740
gene id: 521011:MPAL_RS04740
uniprot id: B8GGP6
names: Similarity
messages: Belongs to the UPF0179 family.

521011:MPAL RS01445
gene id: 521011:MPAL_RS01445
uniprot id: B8GJL3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

521011:MPAL RS02765
gene id: 521011:MPAL_RS02765
uniprot id: B8GEV3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

521011:MPAL RS08690
gene id: 521011:MPAL_RS08690
uniprot id: B8GJY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

521011:MPAL RS09385
gene id: 521011:MPAL_RS09385
uniprot id: B8GKP2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

521011:MPAL RS08445
gene id: 521011:MPAL_RS08445
uniprot id: B8GJG7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

521011:MPAL RS07730
gene id: 521011:MPAL_RS07730
uniprot id: B8GIR0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

521011:MPAL RS02705
gene id: 521011:MPAL_RS02705
uniprot id: B8GEU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

521011:MPAL RS08630
gene id: 521011:MPAL_RS08630
uniprot id: B8GJK1
names: Similarity
messages: Belongs to the HypE family.

521011:MPAL RS02695
gene id: 521011:MPAL_RS02695
uniprot id: B8GET9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

521011:MPAL RS05630
gene id: 521011:MPAL_RS05630
uniprot id: B8GH70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521011:MPAL RS00190
gene id: 521011:MPAL_RS00190
uniprot id: B8GI81
names: Similarity
messages: Belongs to the CutA family.

521011:MPAL RS10265
gene id: 521011:MPAL_RS10265
uniprot id: B8GDK4
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS08525
gene id: 521011:MPAL_RS08525
uniprot id: B8GJI1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

521011:MPAL RS00420
gene id: 521011:MPAL_RS00420
uniprot id: B8GIC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

521011:MPAL RS07225
gene id: 521011:MPAL_RS07225
uniprot id: B8GI35
names: Subcellular Location Annotation
messages: Membrane

521011:MPAL RS11540
gene id: 521011:MPAL_RS11540
uniprot id: B8GE96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

521011:MPAL RS02540
gene id: 521011:MPAL_RS02540
uniprot id: B8GKJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

521011:MPAL RS02035
gene id: 521011:MPAL_RS02035
uniprot id: B8GJX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

521011:MPAL RS00880
gene id: 521011:MPAL_RS00880
uniprot id: B8GIZ1
names: Similarity
messages: Belongs to the TrpF family.

521011:MPAL RS14585
gene id: 521011:MPAL_RS14585
uniprot id: B8GK08
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

521011:MPAL RS03695
gene id: 521011:MPAL_RS03695
uniprot id: B8GG22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521011:MPAL RS01530
gene id: 521011:MPAL_RS01530
uniprot id: B8GJM8
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

521011:MPAL RS04680
gene id: 521011:MPAL_RS04680
uniprot id: B8GGN4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

521011:MPAL RS08660
gene id: 521011:MPAL_RS08660
uniprot id: B8GJK6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

521011:MPAL RS01290
gene id: 521011:MPAL_RS01290
uniprot id: B8GJ65
names: Similarity
messages: Belongs to the UPF0288 family.

521011:MPAL RS06240
gene id: 521011:MPAL_RS06240
uniprot id: B8GHH8
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

521011:MPAL RS02130
gene id: 521011:MPAL_RS02130
uniprot id: B8GKB0
names: Similarity
messages: Belongs to the DMRL synthase family.

521011:MPAL RS03965
gene id: 521011:MPAL_RS03965
uniprot id: B8GG66
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

521011:MPAL RS02265
gene id: 521011:MPAL_RS02265
uniprot id: B8GKD7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

521011:MPAL RS00415
gene id: 521011:MPAL_RS00415
uniprot id: B8GIC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

521011:MPAL RS13910
gene id: 521011:MPAL_RS13910
uniprot id: B8GGC0
names: Similarity
messages: Belongs to the P(II) protein family.

521011:MPAL RS02810
gene id: 521011:MPAL_RS02810
uniprot id: B8GEW2
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).