Belongs to the tRNA pseudouridine synthase TruA family.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Belongs to the universal ribosomal protein uS7 family.
Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.
Belongs to the universal ribosomal protein uS9 family.
Plays a role in vesicular protein sorting.
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
Belongs to the eukaryotic ribosomal protein eS30 family.
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.
Lacks conserved residue(s) required for the propagation of feature annotation.
Belongs to the V-ATPase 116 kDa subunit family.
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
Belongs to the lariat debranching enzyme family.
Belongs to the universal ribosomal protein uS14 family.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Belongs to the phosphoglycerate kinase family.
Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
Belongs to the universal ribosomal protein uL13 family.
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
Belongs to the acetyltransferase ATAT1 family.
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Belongs to the universal ribosomal protein uS17 family.
Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Belongs to the actin-binding proteins ADF family.
Belongs to the universal ribosomal protein uS15 family.
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Belongs to the inositol phosphokinase (IPK) family.
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Belongs to the peptidase M24 family. SPT16 subfamily.
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Belongs to the small GTPase superfamily. Arf family.
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Belongs to the EF-1-beta/EF-1-delta family.
Belongs to the universal ribosomal protein uL5 family.
Belongs to the glutamate--cysteine ligase type 3 family.
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
Belongs to the ClpX chaperone family. HslU subfamily.
Belongs to the 2-oxoacid dehydrogenase family.
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Component of a multi-subunit COQ enzyme complex.
Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Belongs to the eukaryotic ribosomal protein eL24 family.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Component of the dolichol-phosphate mannose (DPM) synthase complex.
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
Monomer. Associates with the 60S ribosomal subunit.
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Belongs to the apicomplexan parasites AMA1 family.
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Belongs to the glycosyltransferase group 1 family.
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Belongs to the methyltransferase superfamily. RsmH family.
Belongs to the GTP cyclohydrolase I family.
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Belongs to the class-II aminoacyl-tRNA synthetase family.
Belongs to the proteasome inhibitor PI31 family.
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Component of the ER membrane protein complex (EMC).
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Belongs to the iron/manganese superoxide dismutase family.
Belongs to the eukaryotic ribosomal protein eS10 family.
Belongs to the RNA polymerase beta chain family.
In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
Component of the 7-subunit TFIIH core complex.
In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Belongs to the thiolase-like superfamily. Thiolase family.
Belongs to the fatty acyl-CoA reductase family.
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Catalytic component of the tRNA-splicing ligase complex.
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
Belongs to the endoribonuclease YbeY family.
Belongs to the DNA mismatch repair MutL/HexB family.
Belongs to the PEP-utilizing enzyme family.
May bind zinc and other divalent cations and recruit them to vesicular organelles.
Binds 1 divalent metal cation per subunit.
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Component of the EKC/KEOPS complex; the whole complex dimerizes.
Belongs to the bacterial ribosomal protein bL33 family.
Associates with the pre-60S ribosomal particle.
Belongs to the universal ribosomal protein uL10 family.
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Belongs to the replication factor A protein 1 family.
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Belongs to the snRNP core protein family.
Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures.
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Belongs to the protein kinase superfamily.
Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Belongs to the universal ribosomal protein uL23 family.
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Belongs to the small heat shock protein (HSP20) family.
Belongs to the class-I aminoacyl-tRNA synthetase family.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
Belongs to the MsrA Met sulfoxide reductase family.
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Belongs to the WD repeat peroxin-7 family.
Belongs to the acyl-CoA dehydrogenase family.
Belongs to the eukaryotic ribosomal protein eL32 family.
Belongs to the thiolase-like superfamily. FabH family.
Belongs to the adaptor complexes small subunit family.
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Belongs to the TRAPP small subunits family. BET3 subfamily.
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Belongs to the methyltransferase superfamily. RRP8 family.
Probable methyltransferase required to silence rDNA.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
Belongs to the cyclic nucleotide phosphodiesterase family.
Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Belongs to the SWEET sugar transporter family.
Belongs to the DNA polymerase alpha subunit B family.
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
Belongs to the diacylglycerol acyltransferase family.
Belongs to the methyltransferase superfamily.
Belongs to the proteasome subunit S1 family.
Belongs to the eukaryotic ribosomal protein eL28 family.
Belongs to the bacterial ribosomal protein bL35 family.
Belongs to the eukaryotic ribosomal protein eS28 family.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
Belongs to the snRNP Sm proteins family.
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
Necessary for protein translocation in the endoplasmic reticulum.
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Belongs to the adaptor complexes medium subunit family.
Belongs to the splicing factor SR family.
Belongs to the proteasome subunit S3 family.
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Belongs to the AB hydrolase superfamily.
Demethylates proteins that have been reversibly carboxymethylated.
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Belongs to the strictosidine synthase family.
Belongs to the Rieske iron-sulfur protein family.
Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Belongs to the STXBP/unc-18/SEC1 family.
Belongs to the phosphohexose mutase family.
Belongs to the glutathione peroxidase family.
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.
The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.
Belongs to the DNA2/NAM7 helicase family.
Belongs to the ubiquitin-conjugating enzyme family.
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Belongs to the glycogen phosphorylase family.
Belongs to the CTL (choline transporter-like) family.
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Belongs to the ANT/ATPSC lysine N-methyltransferase family.
Belongs to the pseudouridine synthase TruD family.
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
Probable GTP-binding protein involved in generating and maintaining the structure of the tubular endoplasmic reticulum network.
Probable GTP-binding protein that may be involved in cell development.
Belongs to the universal ribosomal protein uL29 family.
Belongs to the heat shock protein 90 family.
Belongs to the universal ribosomal protein uL11 family.
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.
Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
LSm subunits form a heteromer with a doughnut shape.
Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.
Belongs to the proteasome subunit p55 family.
Belongs to the steroid 5-alpha reductase family.
Belongs to the protein prenyltransferase subunit alpha family.
Belongs to the universal ribosomal protein uS12 family.
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
Belongs to the universal ribosomal protein uL15 family.
Belongs to the eukaryotic ribosomal protein eL8 family.
Belongs to the ATPase alpha/beta chains family.
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Common component of the spliceosome and rRNA processing machinery.
Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
Belongs to the dynein light chain family.
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Belongs to the TRAPP small subunits family.
Part of the multisubunit transport protein particle (TRAPP) complex.
Belongs to the tRNA-intron endonuclease family.
Belongs to the DNA polymerase epsilon subunit B family.
Belongs to the small GTPase superfamily. SAR1 family.
Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Belongs to the oligoribonuclease family.
Belongs to the pyrroline-5-carboxylate reductase family.
S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
Belongs to the DEAD box helicase family.
Belongs to the RNA polymerase alpha chain family.
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Belongs to the apicomplexan parasites RON2 family.
Component of the moving junction (MJ) complex, composed of AMA1, a transmembrane protein on the parasite surface, and a complex of the rhoptry neck proteins RON2, RON4, RON5 and RON8 localized to the cytoplasmic face of the host plasma membrane. Interacts (via C-terminus) with AMA1 (via ectodomain); RON2 serves as the receptor for AMA1 on the host plasma membrane. AMA1 and the RON proteins are initially in distinct compartments within the parasite, namely the micronemes and the rhoptries, and interaction happens only upon initiation of invasion when the micronemes and rhoptries discharge.
Essential rhoptry neck protein that plays an important role in host cell invasion. Upon host invasion by tachyzoites, the protein is injected into the host cell where it functions as a receptor for apical membrane antigen 1 (AMA1) on the parasite. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).
Belongs to the XPG/RAD2 endonuclease family.
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Part of the nascent polypeptide-associated complex (NAC).
Involved in autophagic vesicle formation.
Belongs to the methyltransferase superfamily. LCMT family.
Belongs to the GTR/RAG GTP-binding protein family.
Belongs to the aldehyde dehydrogenase family.
Belongs to the universal ribosomal protein uL3 family.
Involved in ribosomal large subunit assembly.
Belongs to the class I fructose-bisphosphate aldolase family.
Belongs to the polyprenol kinase family.
Belongs to the heat shock protein 70 family.
Belongs to the PDK/BCKDK protein kinase family.
Belongs to the ubiquitin conjugation factor E4 family.
Belongs to the DNA polymerase type-B family.
Belongs to the prefoldin subunit alpha family.
Belongs to the proteasome subunit S5A family.
Belongs to the transaldolase family. Type 1 subfamily.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Belongs to the activator 1 large subunit family.
Belongs to the V-ATPase proteolipid subunit family.
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Belongs to the nucleosome assembly protein (NAP) family.
Belongs to the phosphatase 2A regulatory subunit.
Belongs to the type IA topoisomerase family.
Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
Belongs to the eukaryotic ribosomal protein eS6 family.
Belongs to the histone deacetylase family. HD Type 1 subfamily.
Catalyzes the exchange of ADP and ATP across the membrane.
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Belongs to the cyclophilin-type PPIase family.
Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Belongs to the eIF-2B alpha/beta/delta subunits family.
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Belongs to the ubiquitin-activating E1 family.
Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
Belongs to the DHHC palmitoyltransferase family.
The DHHC domain is required for palmitoyltransferase activity.
Belongs to the eukaryotic ribosomal protein eL19 family.
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
Belongs to the chaperonin (HSP60) family.
Belongs to the adaptor complexes large subunit family.
Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
Belongs to the universal ribosomal protein uS4 family.
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
Belongs to the bacterial ribosomal protein bL9 family.
Belongs to the universal ribosomal protein uL14 family.
Belongs to the zinc-containing alcohol dehydrogenase family.
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
Belongs to the dynein heavy chain family.
Belongs to the phage and mitochondrial RNA polymerase family.
Belongs to the eukaryotic initiation factor 4E family.
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Belongs to the cytochrome c oxidase subunit 2 family.
Belongs to the activator 1 small subunits family.
Belongs to the methyltransferase superfamily. NTM1 family.
Belongs to the ribose 5-phosphate isomerase family.
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Belongs to the pseudouridine synthase Pus10 family.
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.
Belongs to the AAA ATPase family. BCS1 subfamily.
Belongs to the succinate/malate CoA ligase beta subunit family.
Heterodimer of an alpha and a beta subunit.
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Belongs to the cAMP-dependent kinase regulatory chain family.
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Belongs to the type II topoisomerase family.
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Belongs to the clathrin light chain family.
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Belongs to the MsrB Met sulfoxide reductase family.
Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
Belongs to the helicase family. RAD25/XPB subfamily.
Belongs to the universal ribosomal protein uS2 family.
Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with ribosomal protein S21.
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Belongs to the WD repeat PRL1/PRL2 family.
Belongs to the ferredoxin--NADP reductase type 1 family.
Belongs to the glycosyl hydrolase 17 family.
Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
Belongs to the FKBP-type PPIase family. Tig subfamily.
Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.
Belongs to the eukaryotic ribosomal protein eL18 family.
Belongs to the ATP:guanido phosphotransferase family.
Belongs to the eukaryotic ribosomal protein eS19 family.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Belongs to the eukaryotic ribosomal protein eL22 family.
Belongs to the copper/topaquinone oxidase family.
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
Belongs to the eukaryotic diacylglycerol kinase family.
Belongs to the bacterial ribosomal protein bS6 family.
Belongs to the mitochondrion-specific ribosomal protein mL54 family.
Belongs to the uroporphyrinogen-III synthase family.
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Probably involved in the biogenesis of the COX complex.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Belongs to the bacterial ribosomal protein bL27 family.
Belongs to the cysteine dioxygenase family.
Belongs to the universal ribosomal protein uL22 family.
Belongs to the plant tobamovirus multiplication TOM1 protein family.
Belongs to the acetyltransferase family. MAK3 subfamily.
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Belongs to the acyl carrier protein (ACP) family.
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Belongs to the universal ribosomal protein uS13 family.
Belongs to the pseudouridine synthase TruB family.
Belongs to the mitochondrion-specific ribosomal protein mL49 family.
Belongs to the eukaryotic ribosomal protein eL37 family.
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
Belongs to the peroxiredoxin family. Prx5 subfamily.
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Belongs to the ALG6/ALG8 glucosyltransferase family.
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
Belongs to the peptidase T1B family. HslV subfamily.
Belongs to the ALG10 glucosyltransferase family.
Belongs to the prokaryotic/mitochondrial release factor family.
Belongs to the universal ribosomal protein uS8 family.
Belongs to the type II topoisomerase GyrA/ParC subunit family.
Belongs to the fatty acid desaturase type 1 family.
The histidine box domains are involved in binding the catalytic metal ions.
Belongs to the cytidylyltransferase family.
Belongs to the glucose-6-phosphate dehydrogenase family.
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
Belongs to the ERCC1/RAD10/SWI10 family.
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Belongs to the eukaryotic ATPase epsilon family.
Belongs to the eukaryotic ribosomal protein eL27 family.
Belongs to the eukaryotic-type primase large subunit family.
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Belongs to the inositol monophosphatase superfamily.
Belongs to the eukaryotic ribosomal protein eL14 family.
In the C-terminal section; belongs to the NAD synthetase family.
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Belongs to the sterol desaturase family. SCS7 subfamily.
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
Belongs to the protein disulfide isomerase family.
In the C-terminal section; belongs to the anthranilate synthase component I family.
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
Component of an histone acetyltransferase complex.
Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
The PHD-type zinc finger mediates the binding to H3K4me3.
Belongs to the transketolase family. DXPS subfamily.
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
Belongs to the very long-chain fatty acids dehydratase HACD family.
Belongs to the succinate/malate CoA ligase alpha subunit family.
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Belongs to the U2 small nuclear ribonucleoprotein A family.
Belongs to the eukaryotic ribosomal protein eL38 family.
Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
Belongs to the mannose-6-phosphate isomerase type 1 family.
Belongs to the eukaryotic release factor 1 family.
Heterodimer of two subunits, one of which binds GTP.
Belongs to the casein kinase 2 subunit beta family.
Tetramer of two alpha and two beta subunits.
Belongs to the CRT-like transporter family.
Belongs to the protein prenyltransferase subunit beta family.
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.
Belongs to the methyltransferase TRM13 family.
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Belongs to the SLC43A transporter (TC 2.A.1.44) family.
Impaired parasite growth under conditions of restricted arginine availability (PubMed:28205520). Does not cause toxoplasmosis in mice (PubMed:28205520).
Selective L-arginine transporter that is essential for parasite survival and virulence (PubMed:28205520, PubMed:30742695). Does not require other inorganic ions such as sodium, chloride, potassium or calcium (PubMed:28205520).
Belongs to the eukaryotic ribosomal protein eS1 family.
Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Belongs to the flagellar radial spoke RSP3 family.
Belongs to the bacterial ribosomal protein bL28 family.
Non-catalytic component of the proteasome.
Belongs to the bacterial ribosomal protein bL20 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
Belongs to the clathrin heavy chain family.
In the C-terminal section; belongs to the DHPS family.
Belongs to the diphthine synthase family.
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.
Belongs to the eukaryotic ribosomal protein eL6 family.
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
Mediates the uptake of pyruvate into mitochondria.
Belongs to the universal ribosomal protein uS10 family.
Belongs to the RNA polymerase beta' chain family.
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Activated by threonine and tyrosine phosphorylation.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
Belongs to the RNase HII family. Eukaryotic subfamily.
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
Belongs to the acetyltransferase family. GCN5 subfamily.
Belongs to the eukaryotic ribosomal protein eL15 family.
Belongs to the V-ATPase V0D/AC39 subunit family.
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
Belongs to the FNT transporter (TC 2.A.44) family.
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Belongs to the GMC oxidoreductase family.
Belongs to the Tim17/Tim22/Tim23 family.
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Belongs to the universal ribosomal protein uL6 family.
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Belongs to the glycosyl hydrolases 36 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Belongs to the ketopantoate reductase family.
Belongs to the DEAD box helicase family. DDX41 subfamily.
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Belongs to the universal ribosomal protein uL4 family.
Belongs to the adenylosuccinate synthetase family.
Parasitic protozoa lack the de novo purine biosynthesis pathway and rely exclusively on the salvage pathway for their purine nucleotide requirements.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Belongs to the SRP receptor beta subunit family.
Belongs to the glycosyltransferase 28 family.
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Part of the multisubunit TRAPP (transport protein particle) complex.
Belongs to the DPH1/DPH2 family. DPH2 subfamily.
Belongs to the SMC family. SMC2 subfamily.
Belongs to the bacterial ribosomal protein bS16 family.
Belongs to the ribose-phosphate pyrophosphokinase family.
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
In the N-terminal section; belongs to the ubiquitin family.
Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Belongs to the WD repeat DCAF13/WDSOF1 family.
Belongs to the lipase maturation factor family.
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
Binds 1 pyruvoyl group covalently per subunit.
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
Belongs to the glutaminase PdxT/SNO family.
Belongs to the eukaryotic ribosomal protein eS24 family.
Belongs to the proteasome subunit S11 family.
Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
Belongs to the eukaryotic ribosomal protein eL34 family.
Belongs to the mitochondrion-specific ribosomal protein mL43 family.
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Belongs to the dynein light intermediate chain family.
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
Belongs to the methyltransferase superfamily. METL family.
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
Belongs to the universal ribosomal protein uS11 family.
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Belongs to the peptidase M67A family. CSN5 subfamily.
Belongs to the glycosyl hydrolase 31 family.
Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.
Belongs to the Mediator complex subunit 7 family.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Belongs to the universal ribosomal protein uL18 family.
Belongs to the DNA/RNA non-specific endonuclease family.
Belongs to the eukaryotic ribosomal protein eS25 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
In the C-terminal section; belongs to the sulfate adenylyltransferase family.
In the N-terminal section; belongs to the APS kinase family.
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
Belongs to the eukaryotic ribosomal protein eL42 family.
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Required for 60S pre-ribosomal subunits export to the cytoplasm.
Belongs to the ETF beta-subunit/FixA family.
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
Belongs to the SOS response-associated peptidase family.
Belongs to the WD repeat BOP1/ERB1 family.
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Belongs to the DNA mismatch repair MutS family.
Component of the post-replicative DNA mismatch repair system (MMR).
Belongs to the cytochrome c-type heme lyase family.
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Belongs to the RecA family. DMC1 subfamily.
Belongs to the pyridoxine kinase family.
Belongs to the Mediator complex subunit 14 family.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
Belongs to the helicase family. RecQ subfamily.
Belongs to the universal ribosomal protein uL2 family.
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Component of the oligosaccharyltransferase (OST) complex.
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
Component of the pre-66S ribosomal particle.
Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
Belongs to the Mrp/NBP35 ATP-binding proteins family.
Belongs to the universal ribosomal protein uS19 family.
Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
Belongs to the helicase family. RAD3/XPD subfamily.
Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
Belongs to the type IB topoisomerase family.
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Belongs to the V-ATPase C subunit family.
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.
Component of the 60S subunit of the ribosome.
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
Belongs to the peroxisomal targeting signal receptor family.
Belongs to the universal ribosomal protein uS3 family.
Belongs to the 2Fe2S plant-type ferredoxin family.
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Belongs to the bacterial ribosomal protein bL19 family.
Belongs to the DDOST 48 kDa subunit family.
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
Regulates also the sphingolipid metabolism.
Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.
Belongs to the glycosyl hydrolase 27 family.
Belongs to the bacterial histone-like protein family.
Belongs to the F-actin-capping protein beta subunit family.
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
Belongs to the polypeptide deformylase family.
Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Involved in nucleolar processing of pre-18S ribosomal RNA.
Belongs to the DEAD box helicase family. eIF4A subfamily.
Readily detected in oocysts (at protein level). Specifically up-regulated in sporozoites, but not in tachyzoites and bradyzoites.
Belongs to the GPI inositol-deacylase family.
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Belongs to the glycosyltransferase 4 family.
Belongs to the thymidylate kinase family.
Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
Belongs to the MICOS complex subunit Mic60 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Belongs to the 6-phosphogluconate dehydrogenase family.
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Belongs to the ATPase gamma chain family.
Belongs to the CND2 (condensin subunit 2) family.
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Belongs to the elongation factor P family.
Belongs to the gamma-glutamylcyclotransferase family.
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Belongs to the eukaryotic ribosomal protein eS26 family.
Belongs to the eukaryotic initiation factor 4G family.
Belongs to the TRAPP small subunits family. Sedlin subfamily.
Belongs to the proteasome subunit S2 family.
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.
Belongs to the NADH dehydrogenase family.
Component of the conserved oligomeric Golgi complex.
Belongs to the eukaryotic ribosomal protein eL21 family.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Belongs to the alpha-ketoglutarate dehydrogenase family.
Belongs to the AAA ATPase family. PCH2 subfamily.
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Belongs to the polyadenylate-binding protein type-1 family.
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Belongs to the eIF-2B gamma/epsilon subunits family.
Belongs to the ATPase delta chain family.
Belongs to the nucleoporin NSP1/NUP62 family.
Belongs to the reverse transcriptase family. Telomerase subfamily.
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Belongs to the glycosyltransferase 2 family.
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
Belongs to the adenosylhomocysteinase family.
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Belongs to the universal ribosomal protein uL16 family.
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
In the C-terminal section; belongs to the trehalose phosphatase family.
In the N-terminal section; belongs to the glycosyltransferase 20 family.
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
Belongs to the eukaryotic ribosomal protein eS21 family.
Belongs to the glycosyltransferase 48 family.
Belongs to the eukaryotic ribosomal protein eS12 family.
Belongs to the aerobic coproporphyrinogen-III oxidase family.
Component of the ribosomal small subunit (SSU) processome.
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Belongs to the UbiA prenyltransferase family.
Converts protoheme IX and farnesyl diphosphate to heme O.
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
Belongs to the SMC family. SMC5 subfamily.
Belongs to the peroxisomal membrane protein PXMP2/4 family.
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Belongs to the class-II DAHP synthase family.
Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton.
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Belongs to the triosephosphate isomerase family.
Belongs to the calcineurin regulatory subunit family.
Belongs to the V-ATPase E subunit family.
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.
Belongs to the acetyltransferase family. NAA40 subfamily.
LSm subunits form a heteromer with a donut shape.
Probably involved with other LSm subunits in the general process of degradation of mRNAs.
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Belongs to the acetyltransferase family. ARD1 subfamily.
Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Belongs to the small GTPase superfamily. Ran family.
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
Belongs to the uroporphyrinogen decarboxylase family.
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Belongs to the proteasome subunit S9 family.
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Belongs to the eukaryotic ribosomal protein eL30 family.
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Belongs to the enoyl-CoA hydratase/isomerase family.
Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
Belongs to the inositol monophosphatase superfamily. CysQ family.
Belongs to the bacterial ribosomal protein bL12 family.
Belongs to the PA-phosphatase related phosphoesterase family.
Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
The active site is a redox-active disulfide bond.
Belongs to the bacterial ribosomal protein bL21 family.
Belongs to the PPP phosphatase family. BSU subfamily.
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Belongs to the eukaryotic ribosomal protein eL31 family.
Belongs to the poly(ADP-ribose) glycohydrolase family.
Belongs to the carbohydrate kinase PfkB family.
Belongs to the ATP-dependent AMP-binding enzyme family.
Belongs to the poly(A) polymerase family.
During host cell infection by tachyzoites, does not play a role in tethering the parasitophorous vacuole to the host mitochondria, probably because it does not bind host mitochondrial import protein TOMM70.
Expressed in tachyzoites (at protein level).
The MAF1 locus encodes multiple tandemly duplicated paralogs that vary in expression, sequence and copy number across T.gondii strains (PubMed:26920761). For instance, type I strain GT1 has 6 copies, type I strain RH has 4 copies, type II strains ME49 and PRU have 4 copies, type III strain VEG has 4 copies and type III strain CTG has only 2 copies (PubMed:26920761). The paralogs are classified into two groups, a and b and have probably arisen from the neofunctionalization of an ancestral MAF1 a gene (PubMed:26920761). They are characterized by the presence or absence of a repetitive stretch of 4 to 7 prolines followed by a serine (P(4:7)S), as well as differences in the amino acids surrounding the proline motif (PubMed:26920761). This motif is either completely missing (a and b0 paralogs) or repeated up to six times (b paralogs) (PubMed:26920761). Across the strains, transcript levels for the a paralogs are similar, however, in type II strain ME49, transcript levels for the b paralogs are low and no paralog MAF1 b1 protein is produced (PubMed:26920761). Paralogs differ in their ability to mediate host mitochondrial association (HMA), but also in their ability to confer a selective advantage during infection in a mouse model (PubMed:26920761). Tachyzoites from type I and III strains associate with host mitochondria (HMA(+)), while tachyzoites from type II strains, such as ME49, do not associate with host mitochondria (HMA(-)) due to a lack of MAF1 b1 expression (PubMed:26920761).
In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
Belongs to the bacterial ribosomal protein bL17 family.
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Belongs to the ATP-dependent DNA ligase family.
Belongs to the eukaryotic ribosomal protein eL13 family.
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Belongs to the tubulin--tyrosine ligase family.
Belongs to the peroxiredoxin family. Prx6 subfamily.
Belongs to the prefoldin subunit beta family.
Belongs to the eukaryotic ribosomal protein eL39 family.
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Belongs to the V-ATPase F subunit family.
Belongs to the eukaryotic ribosomal protein eS7 family.
Belongs to the CWC16 family. YJU2 subfamily.
Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.
Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
Belongs to the phosphatidylethanolamine-binding protein family.
Belongs to the universal ribosomal protein uS5 family.
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
Belongs to the glycosyl hydrolase 35 family.
Belongs to the glycosyltransferase 22 family.
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Tetramer of two alpha (regulatory) and two beta (catalytic) chains.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Belongs to the protein kinase superfamily. ADCK protein kinase family.
Belongs to the eukaryotic ribosomal protein eL36 family.
Belongs to the eukaryotic ribosomal protein eL43 family.
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Belongs to the HesB/IscA family. Ycf83 subfamily.
Belongs to the eukaryotic-type primase small subunit family.
Maintains high levels of reduced glutathione in the cytosol.
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
In the C-terminal section; belongs to the MoeA family.
Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Belongs to the DNA repair enzymes AP/ExoA family.
Probably binds two magnesium or manganese ions per subunit.
Converts proline to delta-1-pyrroline-5-carboxylate.
Belongs to the dus family. Dus3 subfamily.
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
Belongs to the V-ATPase D subunit family.
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
Belongs to the Mediator complex subunit 6 family.
Belongs to the replication factor A protein 3 family.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Belongs to the adenylate kinase family. AK6 subfamily.
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Belongs to the V-ATPase G subunit family.
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Belongs to the deoxyhypusine synthase family.
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Belongs to the eukaryotic ribosomal protein eL20 family.
Belongs to the DEAD box helicase family. DDX1 subfamily.
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
Belongs to the chorismate synthase family.
Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
Belongs to the transferase hexapeptide repeat family.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
Belongs to the eukaryotic ribosomal protein eL29 family.
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
Belongs to the trans-sulfuration enzymes family.
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
Belongs to the AP endonuclease 2 family.
Belongs to the aconitase/IPM isomerase family.
Belongs to the pseudouridine synthase RluA family.
Belongs to the eukaryotic ribosomal protein eS4 family.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
Belongs to the eukaryotic ribosomal protein eS17 family.
Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
Belongs to the carbohydrate kinase pfkB family.
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.
Belongs to the RNA methyltransferase RsmE family.
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
Belongs to the folylpolyglutamate synthase family.
Belongs to the V-ATPase H subunit family.
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Belongs to the LanC-like protein family.
Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Belongs to the universal ribosomal protein uL1 family.
Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
Belongs to the prenylcysteine oxidase family.
Belongs to the fluoride exporter Fluc/FEX family.
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
Belongs to the actin family. ARP6 subfamily.
Belongs to the protein kinase superfamily. BUD32 family.
Belongs to the AB hydrolase superfamily. MetX family.
Belongs to the PPP phosphatase family. PP-2B subfamily.
Belongs to the ETF alpha-subunit/FixB family.
Belongs to the DNA polymerase type-Y family.
Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation. The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen. PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase. The VTC complex also plays a role in vacuolar membrane fusion.
The SPX domain has very high affinity for inositol polyphosphates. SPX domains may integrate inositol pyrophosphates (PP-InsP)-dependent signaling to adapt cytosolic phosphate concentrations to different metabolic situations.
The VTC core complex is an integral membrane heterooligomer composed of at least the catalytic subunit vtc4 and the accessory subunits vtc1 and vtc2. vtc1 is a small membrane protein without hydrophilic domain. Vtc2 and vtc4 are related and have 2 hydrophilic domains that face the cytosol, an N-terminal SPX domain and the central core domain. The central core in vtc4 is the catalytic domain.
The VTC2 locus is refractory to knockout, and may be essential. Partial disruption of the gene results in reduced polyP accumulation.
Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Belongs to the Nudix hydrolase family. DCP2 subfamily.
Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
Belongs to the TTC30/dfy-1/fleer family.
Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Belongs to the mitochondrion-specific ribosomal protein mS29 family.
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Belongs to the disproportionating enzyme family.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
Binds 1 thiamine pyrophosphate per subunit.
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Belongs to the UTP23/FCF1 family. FCF1 subfamily.
Belongs to the glycosyltransferase 13 family.
Belongs to the RecA family. RAD51 subfamily.
Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.
Expressed at a similar level during both the chronic and acute stages of infection (PubMed:31955846). However, transcripts are only translated during the chronic stage of infection, in response to stress conditions (PubMed:31955846).
Master transcription factor that controls the differentiation of acute-stage tachyzoite parasites into chronic-stage bradyzoites, which form intracellular cysts resistant to immune clearance and existing therapies (PubMed:31955846). Sufficient to drive differentiation into bradyzoite stage (PubMed:31955846). Following translation in response to stress conditions, binds to the promoter of many chronic stage-specific genes and promotes their expression, thereby driving differentiation into bradyzoites (PubMed:31955846).
Parasites grow normally under standard conditions but fail to differentiate into chronic-stage bradyzoites under all induction conditions tested (PubMed:31955846). Parasites are unable to form brain cysts in mice (PubMed:31955846).
Regulated at the translation level: while it is expressed during both the chronic and acute stages of infection, transcripts are only translated during the chronic stage of infection.
Involved in the early part of the secretory pathway.
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.
In the C-terminal section; belongs to the peptidase M41 family.
In the N-terminal section; belongs to the AAA ATPase family.
Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
Belongs to the glycosyl hydrolase 63 family.
Belongs to the cytidine and deoxycytidylate deaminase family.
Belongs to the KIF-binding protein family.
Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
Belongs to the eukaryotic ribosomal protein eL33 family.
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Belongs to the Mediator complex subunit 31 family.
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.
Proteolytically removes the C-terminal three residues of farnesylated proteins.
Belongs to the universal ribosomal protein uL30 family.
Belongs to the ribonucleoside diphosphate reductase large chain family.
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Belongs to the GTP-binding elongation factor family. LepA subfamily.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Belongs to the eukaryotic ribosomal protein eS8 family.
Belongs to the exonuclease superfamily. TREX family.
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Belongs to the ATPase epsilon chain family.
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
Plays a fundamental role in microtubule organizing center structure and function. Component of the infraciliary lattice (ICL) and the ciliary basal bodies.
May be involved in calcium-mediated signal transduction.
Belongs to the mitochondrion-specific ribosomal protein mL41 family.
Belongs to the chloride channel (TC 2.A.49) family.
Associates with 90S and pre-40S pre-ribosomal particles.
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Belongs to the glutamine synthetase family.
Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
Belongs to the methyltransferase superfamily. Fibrillarin family.
Belongs to the class IV-like SAM-binding methyltransferase superfamily.
Belongs to the DNA polymerase delta/II small subunit family.
Belongs to the pantothenate synthetase family.
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
Belongs to the ribonucleoside diphosphate reductase small chain family.
Belongs to the eukaryotic ribosomal protein eS27 family.
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
In the C-terminal section; belongs to the thymidylate synthase family.
In the N-terminal section; belongs to the dihydrofolate reductase family.
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
Belongs to the SMC family. RAD50 subfamily.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Belongs to the histone deacetylase family. HD type 1 subfamily.