485917:PHEP RS18535
gene id: 485917:PHEP_RS18535
uniprot id: C6XUB3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

485917:PHEP RS20340
gene id: 485917:PHEP_RS20340
uniprot id: C6XWI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

485917:PHEP RS09185
gene id: 485917:PHEP_RS09185
uniprot id: C6XVI6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS20515
gene id: 485917:PHEP_RS20515
uniprot id: C6XWL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS04200
gene id: 485917:PHEP_RS04200
uniprot id: C6Y268
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

485917:PHEP RS19790
gene id: 485917:PHEP_RS19790
uniprot id: C6XVT4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS01490
gene id: 485917:PHEP_RS01490
uniprot id: C6XZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS03040
gene id: 485917:PHEP_RS03040
uniprot id: C6Y0R7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

485917:PHEP RS10360
gene id: 485917:PHEP_RS10360
uniprot id: C6XX00
names: Similarity
messages: Belongs to the sterol desaturase family.

485917:PHEP RS04880
gene id: 485917:PHEP_RS04880
uniprot id: C6Y2Y3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

485917:PHEP RS05750
gene id: 485917:PHEP_RS05750
uniprot id: C6Y3U3
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS17475
gene id: 485917:PHEP_RS17475
uniprot id: C6XTC4
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

485917:PHEP RS01500
gene id: 485917:PHEP_RS01500
uniprot id: C6XZ43
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS06900
gene id: 485917:PHEP_RS06900
uniprot id: C6XT33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS16665
gene id: 485917:PHEP_RS16665
uniprot id: C6XSI1
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS14630
gene id: 485917:PHEP_RS14630
uniprot id: C6Y2D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

485917:PHEP RS01120
gene id: 485917:PHEP_RS01120
uniprot id: C6XYI4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

485917:PHEP RS14670
gene id: 485917:PHEP_RS14670
uniprot id: C6Y2E7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

485917:PHEP RS06050
gene id: 485917:PHEP_RS06050
uniprot id: C6XS82
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485917:PHEP RS07975
gene id: 485917:PHEP_RS07975
uniprot id: C6XUF7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

485917:PHEP RS00680
gene id: 485917:PHEP_RS00680
uniprot id: C6XY94
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

485917:PHEP RS01955
gene id: 485917:PHEP_RS01955
uniprot id: C6XZS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

485917:PHEP RS18730
gene id: 485917:PHEP_RS18730
uniprot id: C6XUT8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

485917:PHEP RS15495
gene id: 485917:PHEP_RS15495
uniprot id: C6Y387
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS01980
gene id: 485917:PHEP_RS01980
uniprot id: C6XZS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

485917:PHEP RS15725
gene id: 485917:PHEP_RS15725
uniprot id: C6Y3D2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

485917:PHEP RS18135
gene id: 485917:PHEP_RS18135
uniprot id: C6XU32
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS21050
gene id: 485917:PHEP_RS21050
uniprot id: C6XXA6
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

485917:PHEP RS18395
gene id: 485917:PHEP_RS18395
uniprot id: C6XU85
names: Similarity
messages: Belongs to the peptidase M13 family.

485917:PHEP RS02825
gene id: 485917:PHEP_RS02825
uniprot id: C6Y0M6
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS17140
gene id: 485917:PHEP_RS17140
uniprot id: C6XSS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS01515
gene id: 485917:PHEP_RS01515
uniprot id: C6XZ46
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS03945
gene id: 485917:PHEP_RS03945
uniprot id: C6Y217
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS21220
gene id: 485917:PHEP_RS21220
uniprot id: C6XXE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS06095
gene id: 485917:PHEP_RS06095
uniprot id: C6XS91
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

485917:PHEP RS00705
gene id: 485917:PHEP_RS00705
uniprot id: C6XY99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

485917:PHEP RS02930
gene id: 485917:PHEP_RS02930
uniprot id: C6Y0P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

485917:PHEP RS01340
gene id: 485917:PHEP_RS01340
uniprot id: C6XZ11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

485917:PHEP RS05715
gene id: 485917:PHEP_RS05715
uniprot id: C6Y3T6
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS14345
gene id: 485917:PHEP_RS14345
uniprot id: C6Y1V1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS13290
gene id: 485917:PHEP_RS13290
uniprot id: C6Y0V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

485917:PHEP RS02050
gene id: 485917:PHEP_RS02050
uniprot id: C6XZU0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS14020
gene id: 485917:PHEP_RS14020
uniprot id: C6Y1N8
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS04105
gene id: 485917:PHEP_RS04105
uniprot id: C6Y249
names: Similarity
messages: Belongs to the UPF0758 family.

485917:PHEP RS16560
gene id: 485917:PHEP_RS16560
uniprot id: C6Y480
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS09575
gene id: 485917:PHEP_RS09575
uniprot id: C6XW53
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS12450
gene id: 485917:PHEP_RS12450
uniprot id: C6XZM0
names: Similarity
messages: Belongs to the SCO1/2 family.

485917:PHEP RS00165
gene id: 485917:PHEP_RS00165
uniprot id: C6XXK5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS04975
gene id: 485917:PHEP_RS04975
uniprot id: C6Y301
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

485917:PHEP RS17415
gene id: 485917:PHEP_RS17415
uniprot id: C6XTB3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

485917:PHEP RS18030
gene id: 485917:PHEP_RS18030
uniprot id: C6XU11
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

485917:PHEP RS00205
gene id: 485917:PHEP_RS00205
uniprot id: C6XXL3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

485917:PHEP RS19575
gene id: 485917:PHEP_RS19575
uniprot id: C6XU13
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

485917:PHEP RS10590
gene id: 485917:PHEP_RS10590
uniprot id: C6XXS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

485917:PHEP RS09270
gene id: 485917:PHEP_RS09270
uniprot id: C6XVZ1
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

485917:PHEP RS17485
gene id: 485917:PHEP_RS17485
uniprot id: C6XTC6
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

485917:PHEP RS19225
gene id: 485917:PHEP_RS19225
uniprot id: C6XV37
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

485917:PHEP RS02165
gene id: 485917:PHEP_RS02165
uniprot id: C6XZW3
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS15370
gene id: 485917:PHEP_RS15370
uniprot id: C6Y363
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

485917:PHEP RS10260
gene id: 485917:PHEP_RS10260
uniprot id: C6XWY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

485917:PHEP RS13540
gene id: 485917:PHEP_RS13540
uniprot id: C6Y108
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS19125
gene id: 485917:PHEP_RS19125
uniprot id: C6XV17
names: Similarity
messages: Belongs to the transglycosylase Slt family.

485917:PHEP RS15410
gene id: 485917:PHEP_RS15410
uniprot id: C6Y371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

485917:PHEP RS05840
gene id: 485917:PHEP_RS05840
uniprot id: C6Y3V5
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

485917:PHEP RS10355
gene id: 485917:PHEP_RS10355
uniprot id: C6XWZ9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS17645
gene id: 485917:PHEP_RS17645
uniprot id: C6XTG0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

485917:PHEP RS19620
gene id: 485917:PHEP_RS19620
uniprot id: C6XVQ0
names: Similarity
messages: Belongs to the HisA/HisF family.

485917:PHEP RS18470
gene id: 485917:PHEP_RS18470
uniprot id: C6XU99
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS17820
gene id: 485917:PHEP_RS17820
uniprot id: C6XTJ4
names: Similarity
messages: Belongs to the DapA family.

485917:PHEP RS20390
gene id: 485917:PHEP_RS20390
uniprot id: C6XWJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

485917:PHEP RS08955
gene id: 485917:PHEP_RS08955
uniprot id: C6XVE1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS11285
gene id: 485917:PHEP_RS11285
uniprot id: C6XYJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
messages: Monomer.

485917:PHEP RS13450
gene id: 485917:PHEP_RS13450
uniprot id: C6Y0Z0
names: Similarity
messages: Belongs to the bacterial phospholipase C family.

485917:PHEP RS17035
gene id: 485917:PHEP_RS17035
uniprot id: C6XSQ3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS04025
gene id: 485917:PHEP_RS04025
uniprot id: C6Y233
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS18170
gene id: 485917:PHEP_RS18170
uniprot id: C6XU40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

485917:PHEP RS12845
gene id: 485917:PHEP_RS12845
uniprot id: C6Y083
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

485917:PHEP RS15265
gene id: 485917:PHEP_RS15265
uniprot id: C6Y2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

485917:PHEP RS08395
gene id: 485917:PHEP_RS08395
uniprot id: C6XUN9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

485917:PHEP RS04795
gene id: 485917:PHEP_RS04795
uniprot id: C6Y2W6
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS14320
gene id: 485917:PHEP_RS14320
uniprot id: C6Y1U6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS15465
gene id: 485917:PHEP_RS15465
uniprot id: C6Y382
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS17780
gene id: 485917:PHEP_RS17780
uniprot id: C6XTI6
names: Similarity
messages: Belongs to the DapA family.

485917:PHEP RS03025
gene id: 485917:PHEP_RS03025
uniprot id: C6Y0R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

485917:PHEP RS10855
gene id: 485917:PHEP_RS10855
uniprot id: C6XXX5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

485917:PHEP RS14735
gene id: 485917:PHEP_RS14735
uniprot id: C6Y2F9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

485917:PHEP RS02625
gene id: 485917:PHEP_RS02625
uniprot id: C6Y0I7
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

485917:PHEP RS16530
gene id: 485917:PHEP_RS16530
uniprot id: C6Y474
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

485917:PHEP RS14970
gene id: 485917:PHEP_RS14970
uniprot id: C6Y2K6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

485917:PHEP RS03505
gene id: 485917:PHEP_RS03505
uniprot id: C6Y1E7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

485917:PHEP RS10965
gene id: 485917:PHEP_RS10965
uniprot id: C6XXZ7
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS15985
gene id: 485917:PHEP_RS15985
uniprot id: C6Y3W5
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

485917:PHEP RS12425
gene id: 485917:PHEP_RS12425
uniprot id: C6XZL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

485917:PHEP RS14230
gene id: 485917:PHEP_RS14230
uniprot id: C6Y1T0
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS06560
gene id: 485917:PHEP_RS06560
uniprot id: C6XSW6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

485917:PHEP RS15070
gene id: 485917:PHEP_RS15070
uniprot id: C6Y2M6
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

485917:PHEP RS09880
gene id: 485917:PHEP_RS09880
uniprot id: C6XWB5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS14835
gene id: 485917:PHEP_RS14835
uniprot id: C6Y2H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS17470
gene id: 485917:PHEP_RS17470
uniprot id: C6XTC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

485917:PHEP RS04300
gene id: 485917:PHEP_RS04300
uniprot id: C6Y283
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

485917:PHEP RS16690
gene id: 485917:PHEP_RS16690
uniprot id: C6XSI6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

485917:PHEP RS10690
gene id: 485917:PHEP_RS10690
uniprot id: C6XXU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS20965
gene id: 485917:PHEP_RS20965
uniprot id: C6XX89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

485917:PHEP RS12105
gene id: 485917:PHEP_RS12105
uniprot id: C6XZF0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485917:PHEP RS13420
gene id: 485917:PHEP_RS13420
uniprot id: C6Y0Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS05575
gene id: 485917:PHEP_RS05575
uniprot id: C6Y3Q6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

485917:PHEP RS20705
gene id: 485917:PHEP_RS20705
uniprot id: C6XWQ4
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

485917:PHEP RS19405
gene id: 485917:PHEP_RS19405
uniprot id: C6XVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS21110
gene id: 485917:PHEP_RS21110
uniprot id: C6XXB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS20880
gene id: 485917:PHEP_RS20880
uniprot id: C6XX73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

485917:PHEP RS00200
gene id: 485917:PHEP_RS00200
uniprot id: C6XXL2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

485917:PHEP RS11935
gene id: 485917:PHEP_RS11935
uniprot id: C6XZB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polysaccharide lyase 12 family.
messages: Cleaves both heparin and heparan sulfate glycosaminoglycans through a beta-elimination mechanism. Cleaves heparin at alpha-D-GlcNp2S6S(1->4) alpha-L-IdoAp2S and heparan sulfate at alpha-D-GlcNp2Ac(or 2S)6OH(1->4)beta-D-GlcAp.
messages: Homodimer.
messages: Periplasm

485917:PHEP RS18925
gene id: 485917:PHEP_RS18925
uniprot id: C6XUX5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS08840
gene id: 485917:PHEP_RS08840
uniprot id: C6XVB8
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS13055
gene id: 485917:PHEP_RS13055
uniprot id: C6Y0C7
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS11010
gene id: 485917:PHEP_RS11010
uniprot id: C6XY06
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS09490
gene id: 485917:PHEP_RS09490
uniprot id: C6XW36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

485917:PHEP RS06290
gene id: 485917:PHEP_RS06290
uniprot id: C6XSD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS15880
gene id: 485917:PHEP_RS15880
uniprot id: C6Y3G2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

485917:PHEP RS02225
gene id: 485917:PHEP_RS02225
uniprot id: C6XZX5
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS11710
gene id: 485917:PHEP_RS11710
uniprot id: C6XYT4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

485917:PHEP RS14390
gene id: 485917:PHEP_RS14390
uniprot id: C6Y1V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

485917:PHEP RS00285
gene id: 485917:PHEP_RS00285
uniprot id: C6XXM9
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS14740
gene id: 485917:PHEP_RS14740
uniprot id: C6Y2G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

485917:PHEP RS17105
gene id: 485917:PHEP_RS17105
uniprot id: C6XSR7
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS17600
gene id: 485917:PHEP_RS17600
uniprot id: C6XTF1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS11555
gene id: 485917:PHEP_RS11555
uniprot id: C6XYQ3
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS15770
gene id: 485917:PHEP_RS15770
uniprot id: C6Y3E0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485917:PHEP RS16455
gene id: 485917:PHEP_RS16455
uniprot id: C6Y459
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

485917:PHEP RS10845
gene id: 485917:PHEP_RS10845
uniprot id: C6XXX3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

485917:PHEP RS01745
gene id: 485917:PHEP_RS01745
uniprot id: C6XZ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS07170
gene id: 485917:PHEP_RS07170
uniprot id: C6XT88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS11650
gene id: 485917:PHEP_RS11650
uniprot id: C6XYS3
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS05790
gene id: 485917:PHEP_RS05790
uniprot id: C6Y3V1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

485917:PHEP RS21740
gene id: 485917:PHEP_RS21740
uniprot id: C6XST9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS08110
gene id: 485917:PHEP_RS08110
uniprot id: C6XUI4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS14580
gene id: 485917:PHEP_RS14580
uniprot id: C6Y1Z7
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS00610
gene id: 485917:PHEP_RS00610
uniprot id: C6XY81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

485917:PHEP RS09320
gene id: 485917:PHEP_RS09320
uniprot id: C6XW01
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

485917:PHEP RS13085
gene id: 485917:PHEP_RS13085
uniprot id: C6Y0D3
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS18965
gene id: 485917:PHEP_RS18965
uniprot id: C6XUY3
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

485917:PHEP RS10300
gene id: 485917:PHEP_RS10300
uniprot id: C6XWY9
names: Similarity
messages: Belongs to the UPF0502 family.

485917:PHEP RS09545
gene id: 485917:PHEP_RS09545
uniprot id: C6XW47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS17020
gene id: 485917:PHEP_RS17020
uniprot id: C6XSQ0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

485917:PHEP RS07000
gene id: 485917:PHEP_RS07000
uniprot id: C6XT53
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

485917:PHEP RS17175
gene id: 485917:PHEP_RS17175
uniprot id: C6XST1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

485917:PHEP RS11960
gene id: 485917:PHEP_RS11960
uniprot id: C6XZC1
names: Similarity
messages: Belongs to the DinB family.

485917:PHEP RS09340
gene id: 485917:PHEP_RS09340
uniprot id: C6XW05
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

485917:PHEP RS14795
gene id: 485917:PHEP_RS14795
uniprot id: C6Y2H1
names: Similarity
messages: Belongs to the DinB family.

485917:PHEP RS07775
gene id: 485917:PHEP_RS07775
uniprot id: C6XTY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS21300
gene id: 485917:PHEP_RS21300
uniprot id: C6XXF6
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

485917:PHEP RS00780
gene id: 485917:PHEP_RS00780
uniprot id: C6XYB5
names: Similarity
messages: Belongs to the RutC family.

485917:PHEP RS04995
gene id: 485917:PHEP_RS04995
uniprot id: C6Y305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS20530
gene id: 485917:PHEP_RS20530
uniprot id: C6XWL9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

485917:PHEP RS17050
gene id: 485917:PHEP_RS17050
uniprot id: C6XSQ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

485917:PHEP RS19210
gene id: 485917:PHEP_RS19210
uniprot id: C6XV34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

485917:PHEP RS04275
gene id: 485917:PHEP_RS04275
uniprot id: C6Y278
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

485917:PHEP RS14055
gene id: 485917:PHEP_RS14055
uniprot id: C6Y1P5
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.

485917:PHEP RS08255
gene id: 485917:PHEP_RS08255
uniprot id: C6XUL1
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS20000
gene id: 485917:PHEP_RS20000
uniprot id: C6XVX6
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS09415
gene id: 485917:PHEP_RS09415
uniprot id: C6XW21
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

485917:PHEP RS19015
gene id: 485917:PHEP_RS19015
uniprot id: C6XUZ4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

485917:PHEP RS16995
gene id: 485917:PHEP_RS16995
uniprot id: C6XSP5
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

485917:PHEP RS13090
gene id: 485917:PHEP_RS13090
uniprot id: C6Y0D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS01355
gene id: 485917:PHEP_RS01355
uniprot id: C6XZ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

485917:PHEP RS11780
gene id: 485917:PHEP_RS11780
uniprot id: C6XYU8
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS10215
gene id: 485917:PHEP_RS10215
uniprot id: C6XWX1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

485917:PHEP RS15020
gene id: 485917:PHEP_RS15020
uniprot id: C6Y2L6
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

485917:PHEP RS17720
gene id: 485917:PHEP_RS17720
uniprot id: C6XTH5
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS13720
gene id: 485917:PHEP_RS13720
uniprot id: C6Y143
names: Similarity
messages: Belongs to the DinB family.

485917:PHEP RS14425
gene id: 485917:PHEP_RS14425
uniprot id: C6Y1W6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS13955
gene id: 485917:PHEP_RS13955
uniprot id: C6Y1M5
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

485917:PHEP RS13735
gene id: 485917:PHEP_RS13735
uniprot id: C6Y146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS15910
gene id: 485917:PHEP_RS15910
uniprot id: C6Y3G8
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

485917:PHEP RS14460
gene id: 485917:PHEP_RS14460
uniprot id: C6Y1X3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

485917:PHEP RS05010
gene id: 485917:PHEP_RS05010
uniprot id: C6Y308
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS10790
gene id: 485917:PHEP_RS10790
uniprot id: C6XXW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

485917:PHEP RS10230
gene id: 485917:PHEP_RS10230
uniprot id: C6XWX4
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

485917:PHEP RS16060
gene id: 485917:PHEP_RS16060
uniprot id: C6Y3Y0
names: Similarity
messages: Belongs to the DEAD box helicase family.

485917:PHEP RS03320
gene id: 485917:PHEP_RS03320
uniprot id: C6Y1B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

485917:PHEP RS18960
gene id: 485917:PHEP_RS18960
uniprot id: C6XUY2
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

485917:PHEP RS16740
gene id: 485917:PHEP_RS16740
uniprot id: C6XSJ6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS18735
gene id: 485917:PHEP_RS18735
uniprot id: C6XUT9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS07085
gene id: 485917:PHEP_RS07085
uniprot id: C6XT71
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

485917:PHEP RS08060
gene id: 485917:PHEP_RS08060
uniprot id: C6XUH4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

485917:PHEP RS14075
gene id: 485917:PHEP_RS14075
uniprot id: C6Y1P9
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

485917:PHEP RS02690
gene id: 485917:PHEP_RS02690
uniprot id: C6Y0K0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

485917:PHEP RS06555
gene id: 485917:PHEP_RS06555
uniprot id: C6XSW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRP transporter (TC 2.A.7.5) family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS14820
gene id: 485917:PHEP_RS14820
uniprot id: C6Y2H5
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

485917:PHEP RS21865
gene id: 485917:PHEP_RS21865
uniprot id: C6Y0T6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

485917:PHEP RS01060
gene id: 485917:PHEP_RS01060
uniprot id: C6XYH1
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

485917:PHEP RS16565
gene id: 485917:PHEP_RS16565
uniprot id: C6Y481
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS04540
gene id: 485917:PHEP_RS04540
uniprot id: C6Y2R5
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS14880
gene id: 485917:PHEP_RS14880
uniprot id: C6Y2I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS07270
gene id: 485917:PHEP_RS07270
uniprot id: C6XTN2
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

485917:PHEP RS20775
gene id: 485917:PHEP_RS20775
uniprot id: C6XX51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

485917:PHEP RS16555
gene id: 485917:PHEP_RS16555
uniprot id: C6Y479
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

485917:PHEP RS12430
gene id: 485917:PHEP_RS12430
uniprot id: C6XZL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

485917:PHEP RS14005
gene id: 485917:PHEP_RS14005
uniprot id: C6Y1N5
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS03080
gene id: 485917:PHEP_RS03080
uniprot id: C6Y0S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

485917:PHEP RS03090
gene id: 485917:PHEP_RS03090
uniprot id: C6Y0S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

485917:PHEP RS19945
gene id: 485917:PHEP_RS19945
uniprot id: C6XVW5
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

485917:PHEP RS03315
gene id: 485917:PHEP_RS03315
uniprot id: C6Y1A9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS03105
gene id: 485917:PHEP_RS03105
uniprot id: C6Y0T0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

485917:PHEP RS15125
gene id: 485917:PHEP_RS15125
uniprot id: C6Y2N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

485917:PHEP RS00335
gene id: 485917:PHEP_RS00335
uniprot id: C6XXN9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

485917:PHEP RS20445
gene id: 485917:PHEP_RS20445
uniprot id: C6XWK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS13885
gene id: 485917:PHEP_RS13885
uniprot id: C6Y176
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS20785
gene id: 485917:PHEP_RS20785
uniprot id: C6XX53
names: Similarity
messages: Belongs to the TrpC family.

485917:PHEP RS13065
gene id: 485917:PHEP_RS13065
uniprot id: C6Y0C9
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS04770
gene id: 485917:PHEP_RS04770
uniprot id: C6Y2W1
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS21345
gene id: 485917:PHEP_RS21345
uniprot id: C6XXG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

485917:PHEP RS19980
gene id: 485917:PHEP_RS19980
uniprot id: C6XVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS09235
gene id: 485917:PHEP_RS09235
uniprot id: C6XVJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

485917:PHEP RS08970
gene id: 485917:PHEP_RS08970
uniprot id: C6XVE4
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS18980
gene id: 485917:PHEP_RS18980
uniprot id: C6XUY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

485917:PHEP RS14530
gene id: 485917:PHEP_RS14530
uniprot id: C6Y1Y7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS18375
gene id: 485917:PHEP_RS18375
uniprot id: C6XU81
names: Similarity
messages: Belongs to the RecJ family.

485917:PHEP RS11545
gene id: 485917:PHEP_RS11545
uniprot id: C6XYQ1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485917:PHEP RS17010
gene id: 485917:PHEP_RS17010
uniprot id: C6XSP8
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS08155
gene id: 485917:PHEP_RS08155
uniprot id: C6XUJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

485917:PHEP RS20240
gene id: 485917:PHEP_RS20240
uniprot id: C6XWG1
names: Similarity
messages: Belongs to the pirin family.

485917:PHEP RS04015
gene id: 485917:PHEP_RS04015
uniprot id: C6Y231
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

485917:PHEP RS16095
gene id: 485917:PHEP_RS16095
uniprot id: C6Y3Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

485917:PHEP RS10000
gene id: 485917:PHEP_RS10000
uniprot id: C6XWS7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

485917:PHEP RS08685
gene id: 485917:PHEP_RS08685
uniprot id: C6XV80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

485917:PHEP RS07730
gene id: 485917:PHEP_RS07730
uniprot id: C6XTX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

485917:PHEP RS00410
gene id: 485917:PHEP_RS00410
uniprot id: C6XXQ4
names: Similarity
messages: Belongs to the peptidase S66 family.

485917:PHEP RS11120
gene id: 485917:PHEP_RS11120
uniprot id: C6XY28
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS00370
gene id: 485917:PHEP_RS00370
uniprot id: C6XXP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

485917:PHEP RS03935
gene id: 485917:PHEP_RS03935
uniprot id: Q59288
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the polysaccharide lyase 8 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Monomer.

485917:PHEP RS21015
gene id: 485917:PHEP_RS21015
uniprot id: C6XX99
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

485917:PHEP RS13190
gene id: 485917:PHEP_RS13190
uniprot id: C6Y0F2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

485917:PHEP RS16515
gene id: 485917:PHEP_RS16515
uniprot id: C6Y471
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

485917:PHEP RS19045
gene id: 485917:PHEP_RS19045
uniprot id: C6XV01
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

485917:PHEP RS18565
gene id: 485917:PHEP_RS18565
uniprot id: C6XUB9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

485917:PHEP RS08190
gene id: 485917:PHEP_RS08190
uniprot id: C6XUJ9
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

485917:PHEP RS15805
gene id: 485917:PHEP_RS15805
uniprot id: C6Y3E7
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS00995
gene id: 485917:PHEP_RS00995
uniprot id: C6XYF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS10875
gene id: 485917:PHEP_RS10875
uniprot id: C6XXX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

485917:PHEP RS21080
gene id: 485917:PHEP_RS21080
uniprot id: C6XXB2
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS20550
gene id: 485917:PHEP_RS20550
uniprot id: C6XWM3
names: Similarity
messages: Belongs to the peptidase S41A family.

485917:PHEP RS04055
gene id: 485917:PHEP_RS04055
uniprot id: C6Y239
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS02025
gene id: 485917:PHEP_RS02025
uniprot id: C6XZT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

485917:PHEP RS21085
gene id: 485917:PHEP_RS21085
uniprot id: C6XXB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

485917:PHEP RS00125
gene id: 485917:PHEP_RS00125
uniprot id: C6XXJ7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

485917:PHEP RS14730
gene id: 485917:PHEP_RS14730
uniprot id: C6Y2F8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS20400
gene id: 485917:PHEP_RS20400
uniprot id: C6XWJ4
names: Similarity
messages: Belongs to the SUI1 family.

485917:PHEP RS12825
gene id: 485917:PHEP_RS12825
uniprot id: C6Y079
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

485917:PHEP RS18230
gene id: 485917:PHEP_RS18230
uniprot id: C6XU52
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS04660
gene id: 485917:PHEP_RS04660
uniprot id: C6Y2T9
names: Function
names: Similarity
messages: Belongs to the vsr family.
messages: May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.

485917:PHEP RS22050
gene id: 485917:PHEP_RS22050
uniprot id: C6XVG0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS05505
gene id: 485917:PHEP_RS05505
uniprot id: C6Y3P2
names: Similarity
messages: Belongs to the bacterial secretin family.

485917:PHEP RS19215
gene id: 485917:PHEP_RS19215
uniprot id: C6XV35
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS17400
gene id: 485917:PHEP_RS17400
uniprot id: C6XTB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS20395
gene id: 485917:PHEP_RS20395
uniprot id: C6XWJ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS09790
gene id: 485917:PHEP_RS09790
uniprot id: C6XW97
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS13135
gene id: 485917:PHEP_RS13135
uniprot id: C6Y0E2
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS16015
gene id: 485917:PHEP_RS16015
uniprot id: C6Y3X1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

485917:PHEP RS03100
gene id: 485917:PHEP_RS03100
uniprot id: C6Y0S9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

485917:PHEP RS18020
gene id: 485917:PHEP_RS18020
uniprot id: C6XTM4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

485917:PHEP RS06920
gene id: 485917:PHEP_RS06920
uniprot id: C6XT37
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS20695
gene id: 485917:PHEP_RS20695
uniprot id: C6XWQ2
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

485917:PHEP RS03780
gene id: 485917:PHEP_RS03780
uniprot id: C6Y1K1
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS01545
gene id: 485917:PHEP_RS01545
uniprot id: C6XZ52
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS19250
gene id: 485917:PHEP_RS19250
uniprot id: C6XV43
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

485917:PHEP RS10750
gene id: 485917:PHEP_RS10750
uniprot id: C6XXV3
names: Similarity
messages: Belongs to the OsmC/Ohr family.

485917:PHEP RS05695
gene id: 485917:PHEP_RS05695
uniprot id: C6Y3T2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS21055
gene id: 485917:PHEP_RS21055
uniprot id: C6XXA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

485917:PHEP RS15000
gene id: 485917:PHEP_RS15000
uniprot id: C6Y2L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

485917:PHEP RS02015
gene id: 485917:PHEP_RS02015
uniprot id: C6XZT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

485917:PHEP RS03490
gene id: 485917:PHEP_RS03490
uniprot id: C6Y1E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

485917:PHEP RS11485
gene id: 485917:PHEP_RS11485
uniprot id: C6XYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

485917:PHEP RS15315
gene id: 485917:PHEP_RS15315
uniprot id: C6Y353
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

485917:PHEP RS06020
gene id: 485917:PHEP_RS06020
uniprot id: C6XS75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

485917:PHEP RS06390
gene id: 485917:PHEP_RS06390
uniprot id: C6XSE8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.
messages: Belongs to the aromatic-ring hydroxylase family. TetX subfamily.
messages: Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS02715
gene id: 485917:PHEP_RS02715
uniprot id: C6Y0K5
names: Similarity
messages: Belongs to the asparaginase 1 family.

485917:PHEP RS02010
gene id: 485917:PHEP_RS02010
uniprot id: C6XZT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS17665
gene id: 485917:PHEP_RS17665
uniprot id: C6XTG4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485917:PHEP RS06040
gene id: 485917:PHEP_RS06040
uniprot id: C6XS80
names: Similarity
messages: Belongs to the glutathione peroxidase family.

485917:PHEP RS19290
gene id: 485917:PHEP_RS19290
uniprot id: C6XV51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

485917:PHEP RS00420
gene id: 485917:PHEP_RS00420
uniprot id: C6XXQ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS00220
gene id: 485917:PHEP_RS00220
uniprot id: C6XXL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

485917:PHEP RS14085
gene id: 485917:PHEP_RS14085
uniprot id: C6Y1Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS19275
gene id: 485917:PHEP_RS19275
uniprot id: C6XV48
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS01485
gene id: 485917:PHEP_RS01485
uniprot id: C6XZ40
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

485917:PHEP RS00150
gene id: 485917:PHEP_RS00150
uniprot id: C6XXK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

485917:PHEP RS01385
gene id: 485917:PHEP_RS01385
uniprot id: C6XZ20
names: Similarity
messages: Belongs to the UPF0102 family.

485917:PHEP RS09660
gene id: 485917:PHEP_RS09660
uniprot id: C6XW70
names: Similarity
messages: Belongs to the TelA family.

485917:PHEP RS21255
gene id: 485917:PHEP_RS21255
uniprot id: C6XXE7
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS00020
gene id: 485917:PHEP_RS00020
uniprot id: C6XXH6
names: Subcellular Location Annotation
messages: Cytoplasm

485917:PHEP RS02990
gene id: 485917:PHEP_RS02990
uniprot id: C6Y0Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

485917:PHEP RS08700
gene id: 485917:PHEP_RS08700
uniprot id: C6XV83
names: Similarity
messages: Belongs to the FPG family.

485917:PHEP RS11630
gene id: 485917:PHEP_RS11630
uniprot id: C6XYR8
names: Function
names: Similarity
messages: Belongs to the peptidase S9C family.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

485917:PHEP RS20285
gene id: 485917:PHEP_RS20285
uniprot id: C6XWH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS04010
gene id: 485917:PHEP_RS04010
uniprot id: C6Y230
names: Similarity
messages: Belongs to the FemABX family.

485917:PHEP RS06125
gene id: 485917:PHEP_RS06125
uniprot id: C6XS97
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS03235
gene id: 485917:PHEP_RS03235
uniprot id: C6Y192
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

485917:PHEP RS11235
gene id: 485917:PHEP_RS11235
uniprot id: C6XY51
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

485917:PHEP RS10900
gene id: 485917:PHEP_RS10900
uniprot id: C6XXY4
names: Similarity
messages: Belongs to the XseB family.

485917:PHEP RS18280
gene id: 485917:PHEP_RS18280
uniprot id: C6XU62
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

485917:PHEP RS10165
gene id: 485917:PHEP_RS10165
uniprot id: C6XWW1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485917:PHEP RS18550
gene id: 485917:PHEP_RS18550
uniprot id: C6XUB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.

485917:PHEP RS03035
gene id: 485917:PHEP_RS03035
uniprot id: C6Y0R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

485917:PHEP RS18490
gene id: 485917:PHEP_RS18490
uniprot id: C6XUA4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS19555
gene id: 485917:PHEP_RS19555
uniprot id: C6XVN7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

485917:PHEP RS11790
gene id: 485917:PHEP_RS11790
uniprot id: C6XYV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

485917:PHEP RS08115
gene id: 485917:PHEP_RS08115
uniprot id: C6XUI5
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS00685
gene id: 485917:PHEP_RS00685
uniprot id: C6XY95
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485917:PHEP RS14905
gene id: 485917:PHEP_RS14905
uniprot id: C6Y2J3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

485917:PHEP RS18445
gene id: 485917:PHEP_RS18445
uniprot id: C6XU95
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS10120
gene id: 485917:PHEP_RS10120
uniprot id: C6XWV2
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

485917:PHEP RS10865
gene id: 485917:PHEP_RS10865
uniprot id: C6XXX7
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

485917:PHEP RS13525
gene id: 485917:PHEP_RS13525
uniprot id: C6Y105
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

485917:PHEP RS09865
gene id: 485917:PHEP_RS09865
uniprot id: C6XWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS09505
gene id: 485917:PHEP_RS09505
uniprot id: C6XW39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS16025
gene id: 485917:PHEP_RS16025
uniprot id: C6Y3X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

485917:PHEP RS18990
gene id: 485917:PHEP_RS18990
uniprot id: C6XUY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

485917:PHEP RS09855
gene id: 485917:PHEP_RS09855
uniprot id: C6XWB0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS10530
gene id: 485917:PHEP_RS10530
uniprot id: C6XX32
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS20440
gene id: 485917:PHEP_RS20440
uniprot id: C6XWK2
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS18850
gene id: 485917:PHEP_RS18850
uniprot id: C6XUW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS16525
gene id: 485917:PHEP_RS16525
uniprot id: C6Y473
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

485917:PHEP RS12295
gene id: 485917:PHEP_RS12295
uniprot id: C6XZI8
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

485917:PHEP RS18975
gene id: 485917:PHEP_RS18975
uniprot id: C6XUY5
names: Similarity
messages: Belongs to the threonine synthase family.

485917:PHEP RS09485
gene id: 485917:PHEP_RS09485
uniprot id: C6XW35
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS11015
gene id: 485917:PHEP_RS11015
uniprot id: C6XY07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS07055
gene id: 485917:PHEP_RS07055
uniprot id: C6XT65
names: Similarity
messages: Belongs to the phosphohexose mutase family.

485917:PHEP RS09750
gene id: 485917:PHEP_RS09750
uniprot id: C6XW88
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS18215
gene id: 485917:PHEP_RS18215
uniprot id: C6XU49
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS03020
gene id: 485917:PHEP_RS03020
uniprot id: C6Y0R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

485917:PHEP RS03285
gene id: 485917:PHEP_RS03285
uniprot id: C6Y1A3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

485917:PHEP RS09020
gene id: 485917:PHEP_RS09020
uniprot id: C6XVF4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS07760
gene id: 485917:PHEP_RS07760
uniprot id: C6XTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

485917:PHEP RS19160
gene id: 485917:PHEP_RS19160
uniprot id: C6XV24
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

485917:PHEP RS09425
gene id: 485917:PHEP_RS09425
uniprot id: C6XW23
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

485917:PHEP RS14815
gene id: 485917:PHEP_RS14815
uniprot id: C6Y2H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS18310
gene id: 485917:PHEP_RS18310
uniprot id: C6XU68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0187 family.
messages: Membrane

485917:PHEP RS13385
gene id: 485917:PHEP_RS13385
uniprot id: C6Y0X7
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

485917:PHEP RS19330
gene id: 485917:PHEP_RS19330
uniprot id: C6XV59
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS07815
gene id: 485917:PHEP_RS07815
uniprot id: C6XTY9
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

485917:PHEP RS11715
gene id: 485917:PHEP_RS11715
uniprot id: C6XYT5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

485917:PHEP RS20310
gene id: 485917:PHEP_RS20310
uniprot id: C6XWH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

485917:PHEP RS14865
gene id: 485917:PHEP_RS14865
uniprot id: C6Y2I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

485917:PHEP RS07330
gene id: 485917:PHEP_RS07330
uniprot id: C6XTP3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

485917:PHEP RS01470
gene id: 485917:PHEP_RS01470
uniprot id: C6XZ37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

485917:PHEP RS06295
gene id: 485917:PHEP_RS06295
uniprot id: C6XSD1
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS11480
gene id: 485917:PHEP_RS11480
uniprot id: C6XYN8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS06090
gene id: 485917:PHEP_RS06090
uniprot id: C6XS90
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

485917:PHEP RS08305
gene id: 485917:PHEP_RS08305
uniprot id: C6XUM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS19955
gene id: 485917:PHEP_RS19955
uniprot id: C6XVW7
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS04205
gene id: 485917:PHEP_RS04205
uniprot id: C6Y269
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

485917:PHEP RS15360
gene id: 485917:PHEP_RS15360
uniprot id: C6Y361
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

485917:PHEP RS02210
gene id: 485917:PHEP_RS02210
uniprot id: C6XZX2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS00070
gene id: 485917:PHEP_RS00070
uniprot id: C6XXI6
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

485917:PHEP RS11925
gene id: 485917:PHEP_RS11925
uniprot id: C6XZB4
names: Similarity
messages: Belongs to the DinB family.

485917:PHEP RS21320
gene id: 485917:PHEP_RS21320
uniprot id: C6XXG0
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

485917:PHEP RS00950
gene id: 485917:PHEP_RS00950
uniprot id: C6XYE9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS08380
gene id: 485917:PHEP_RS08380
uniprot id: C6XUN6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS10050
gene id: 485917:PHEP_RS10050
uniprot id: C6XWT7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

485917:PHEP RS15570
gene id: 485917:PHEP_RS15570
uniprot id: C6Y3A2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485917:PHEP RS04260
gene id: 485917:PHEP_RS04260
uniprot id: C6Y275
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

485917:PHEP RS07070
gene id: 485917:PHEP_RS07070
uniprot id: C6XT68
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

485917:PHEP RS16895
gene id: 485917:PHEP_RS16895
uniprot id: C6XSM6
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

485917:PHEP RS16540
gene id: 485917:PHEP_RS16540
uniprot id: C6Y476
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

485917:PHEP RS12000
gene id: 485917:PHEP_RS12000
uniprot id: C6XZC9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

485917:PHEP RS19870
gene id: 485917:PHEP_RS19870
uniprot id: C6XVV0
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.
messages: Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man-Glc) to mannose 1-phosphate (Man1P) and glucose.

485917:PHEP RS16520
gene id: 485917:PHEP_RS16520
uniprot id: C6Y472
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS06030
gene id: 485917:PHEP_RS06030
uniprot id: C6XS77
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

485917:PHEP RS00300
gene id: 485917:PHEP_RS00300
uniprot id: C6XXN2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS07140
gene id: 485917:PHEP_RS07140
uniprot id: C6XT82
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS04390
gene id: 485917:PHEP_RS04390
uniprot id: C6Y2A1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS03065
gene id: 485917:PHEP_RS03065
uniprot id: C6Y0S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

485917:PHEP RS16275
gene id: 485917:PHEP_RS16275
uniprot id: C6Y423
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485917:PHEP RS06235
gene id: 485917:PHEP_RS06235
uniprot id: C6XSB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS14080
gene id: 485917:PHEP_RS14080
uniprot id: C6Y1Q0
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS00180
gene id: 485917:PHEP_RS00180
uniprot id: C6XXK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

485917:PHEP RS09720
gene id: 485917:PHEP_RS09720
uniprot id: C6XW82
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

485917:PHEP RS02420
gene id: 485917:PHEP_RS02420
uniprot id: C6Y012
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS18100
gene id: 485917:PHEP_RS18100
uniprot id: C6XU25
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

485917:PHEP RS12620
gene id: 485917:PHEP_RS12620
uniprot id: C6Y038
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

485917:PHEP RS16850
gene id: 485917:PHEP_RS16850
uniprot id: C6XSL8
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS10945
gene id: 485917:PHEP_RS10945
uniprot id: C6XXZ3
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS06210
gene id: 485917:PHEP_RS06210
uniprot id: C6XSB4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS07510
gene id: 485917:PHEP_RS07510
uniprot id: C6XTS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS21365
gene id: 485917:PHEP_RS21365
uniprot id: C6XXG9
names: Similarity
messages: Belongs to the AlaDH/PNT family.

485917:PHEP RS00855
gene id: 485917:PHEP_RS00855
uniprot id: C6XYD0
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

485917:PHEP RS04250
gene id: 485917:PHEP_RS04250
uniprot id: C6Y273
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

485917:PHEP RS17320
gene id: 485917:PHEP_RS17320
uniprot id: C6XSV9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS08500
gene id: 485917:PHEP_RS08500
uniprot id: C6XUQ9
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

485917:PHEP RS14850
gene id: 485917:PHEP_RS14850
uniprot id: C6Y2I2
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

485917:PHEP RS02730
gene id: 485917:PHEP_RS02730
uniprot id: C6Y0K8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

485917:PHEP RS01240
gene id: 485917:PHEP_RS01240
uniprot id: C6XYZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS00215
gene id: 485917:PHEP_RS00215
uniprot id: C6XXL5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

485917:PHEP RS04925
gene id: 485917:PHEP_RS04925
uniprot id: C6Y2Z2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS05885
gene id: 485917:PHEP_RS05885
uniprot id: C6Y3W4
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS10620
gene id: 485917:PHEP_RS10620
uniprot id: C6XXS6
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS20130
gene id: 485917:PHEP_RS20130
uniprot id: C6XWD8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

485917:PHEP RS13590
gene id: 485917:PHEP_RS13590
uniprot id: C6Y118
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS16625
gene id: 485917:PHEP_RS16625
uniprot id: C6Y493
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

485917:PHEP RS20780
gene id: 485917:PHEP_RS20780
uniprot id: C6XX52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

485917:PHEP RS16390
gene id: 485917:PHEP_RS16390
uniprot id: C6Y446
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

485917:PHEP RS10795
gene id: 485917:PHEP_RS10795
uniprot id: C6XXW2
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

485917:PHEP RS02540
gene id: 485917:PHEP_RS02540
uniprot id: C6Y0H0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

485917:PHEP RS00245
gene id: 485917:PHEP_RS00245
uniprot id: C6XXM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

485917:PHEP RS04470
gene id: 485917:PHEP_RS04470
uniprot id: C6Y2B9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS01715
gene id: 485917:PHEP_RS01715
uniprot id: C6XZ86
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS14995
gene id: 485917:PHEP_RS14995
uniprot id: C6Y2L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

485917:PHEP RS03110
gene id: 485917:PHEP_RS03110
uniprot id: C6Y0T1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

485917:PHEP RS04355
gene id: 485917:PHEP_RS04355
uniprot id: C6Y294
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

485917:PHEP RS19245
gene id: 485917:PHEP_RS19245
uniprot id: C6XV42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS12120
gene id: 485917:PHEP_RS12120
uniprot id: C6XZF3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

485917:PHEP RS02590
gene id: 485917:PHEP_RS02590
uniprot id: C6Y0I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS09440
gene id: 485917:PHEP_RS09440
uniprot id: C6XW26
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

485917:PHEP RS04235
gene id: 485917:PHEP_RS04235
uniprot id: C6Y271
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

485917:PHEP RS18130
gene id: 485917:PHEP_RS18130
uniprot id: C6XU31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS18045
gene id: 485917:PHEP_RS18045
uniprot id: C6XU14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

485917:PHEP RS03930
gene id: 485917:PHEP_RS03930
uniprot id: C6Y214
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS12910
gene id: 485917:PHEP_RS12910
uniprot id: C6Y097
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

485917:PHEP RS19120
gene id: 485917:PHEP_RS19120
uniprot id: C6XV16
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

485917:PHEP RS04520
gene id: 485917:PHEP_RS04520
uniprot id: C6Y2D1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS17630
gene id: 485917:PHEP_RS17630
uniprot id: C6XTF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

485917:PHEP RS06495
gene id: 485917:PHEP_RS06495
uniprot id: C6XSG9
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS20835
gene id: 485917:PHEP_RS20835
uniprot id: C6XX63
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

485917:PHEP RS06000
gene id: 485917:PHEP_RS06000
uniprot id: C6XS71
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

485917:PHEP RS11030
gene id: 485917:PHEP_RS11030
uniprot id: C6XY10
names: Similarity
messages: Belongs to the DapA family.

485917:PHEP RS16505
gene id: 485917:PHEP_RS16505
uniprot id: C6Y469
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

485917:PHEP RS03455
gene id: 485917:PHEP_RS03455
uniprot id: C6Y1D7
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

485917:PHEP RS00845
gene id: 485917:PHEP_RS00845
uniprot id: C6XYC8
names: Similarity
messages: Belongs to the CapA family.

485917:PHEP RS09745
gene id: 485917:PHEP_RS09745
uniprot id: C6XW87
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS12210
gene id: 485917:PHEP_RS12210
uniprot id: C6XZH2
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS18555
gene id: 485917:PHEP_RS18555
uniprot id: C6XUB7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

485917:PHEP RS19335
gene id: 485917:PHEP_RS19335
uniprot id: C6XV60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS03340
gene id: 485917:PHEP_RS03340
uniprot id: C6Y1B4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS16700
gene id: 485917:PHEP_RS16700
uniprot id: C6XSI8
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS19570
gene id: 485917:PHEP_RS19570
uniprot id: C6XVP0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

485917:PHEP RS16510
gene id: 485917:PHEP_RS16510
uniprot id: C6Y470
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

485917:PHEP RS19925
gene id: 485917:PHEP_RS19925
uniprot id: C6XVW1
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS17025
gene id: 485917:PHEP_RS17025
uniprot id: C6XSQ1
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Dimer of large and small chains.

485917:PHEP RS16310
gene id: 485917:PHEP_RS16310
uniprot id: C6Y430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS10135
gene id: 485917:PHEP_RS10135
uniprot id: C6XWV5
names: Similarity
messages: Belongs to the type IA topoisomerase family.

485917:PHEP RS22000
gene id: 485917:PHEP_RS22000
uniprot id: C6XUB8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

485917:PHEP RS06100
gene id: 485917:PHEP_RS06100
uniprot id: C6XS92
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS14855
gene id: 485917:PHEP_RS14855
uniprot id: C6Y2I3
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

485917:PHEP RS20910
gene id: 485917:PHEP_RS20910
uniprot id: C6XX78
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

485917:PHEP RS03230
gene id: 485917:PHEP_RS03230
uniprot id: C6Y191
names: Caution
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

485917:PHEP RS03050
gene id: 485917:PHEP_RS03050
uniprot id: C6Y0R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

485917:PHEP RS06715
gene id: 485917:PHEP_RS06715
uniprot id: C6XSZ7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS10350
gene id: 485917:PHEP_RS10350
uniprot id: C6XWZ8
names: Similarity
messages: Belongs to the DNA photolyase family.

485917:PHEP RS18630
gene id: 485917:PHEP_RS18630
uniprot id: C6XUD3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS16935
gene id: 485917:PHEP_RS16935
uniprot id: C6XSN4
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

485917:PHEP RS18340
gene id: 485917:PHEP_RS18340
uniprot id: C6XU74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

485917:PHEP RS18475
gene id: 485917:PHEP_RS18475
uniprot id: C6XUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

485917:PHEP RS00575
gene id: 485917:PHEP_RS00575
uniprot id: C6XY74
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS16235
gene id: 485917:PHEP_RS16235
uniprot id: C6Y415
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

485917:PHEP RS17365
gene id: 485917:PHEP_RS17365
uniprot id: C6XTA2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS10910
gene id: 485917:PHEP_RS10910
uniprot id: C6XXY6
names: Similarity
messages: Belongs to the peptidase S66 family.

485917:PHEP RS04100
gene id: 485917:PHEP_RS04100
uniprot id: C6Y248
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

485917:PHEP RS19940
gene id: 485917:PHEP_RS19940
uniprot id: C6XVW4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS11035
gene id: 485917:PHEP_RS11035
uniprot id: C6XY11
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS19500
gene id: 485917:PHEP_RS19500
uniprot id: C6XVM6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS10830
gene id: 485917:PHEP_RS10830
uniprot id: C6XXX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS14990
gene id: 485917:PHEP_RS14990
uniprot id: C6Y2L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

485917:PHEP RS15800
gene id: 485917:PHEP_RS15800
uniprot id: C6Y3E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

485917:PHEP RS08315
gene id: 485917:PHEP_RS08315
uniprot id: C6XUM3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS09330
gene id: 485917:PHEP_RS09330
uniprot id: C6XW03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

485917:PHEP RS10885
gene id: 485917:PHEP_RS10885
uniprot id: C6XXY1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS20975
gene id: 485917:PHEP_RS20975
uniprot id: C6XX91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.
messages: Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.
messages: Homotrimer.

485917:PHEP RS01995
gene id: 485917:PHEP_RS01995
uniprot id: C6XZS9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

485917:PHEP RS15545
gene id: 485917:PHEP_RS15545
uniprot id: C6Y397
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS06855
gene id: 485917:PHEP_RS06855
uniprot id: C6XT23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

485917:PHEP RS18985
gene id: 485917:PHEP_RS18985
uniprot id: C6XUY7
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

485917:PHEP RS02925
gene id: 485917:PHEP_RS02925
uniprot id: C6Y0P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

485917:PHEP RS15925
gene id: 485917:PHEP_RS15925
uniprot id: C6Y3H1
names: Similarity
messages: Belongs to the peptidase C40 family.

485917:PHEP RS13945
gene id: 485917:PHEP_RS13945
uniprot id: C6Y1M3
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS21260
gene id: 485917:PHEP_RS21260
uniprot id: C6XXE8
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

485917:PHEP RS00035
gene id: 485917:PHEP_RS00035
uniprot id: C6XXH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

485917:PHEP RS20875
gene id: 485917:PHEP_RS20875
uniprot id: C6XX72
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS06185
gene id: 485917:PHEP_RS06185
uniprot id: C6XSA9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

485917:PHEP RS06215
gene id: 485917:PHEP_RS06215
uniprot id: C6XSB5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

485917:PHEP RS10130
gene id: 485917:PHEP_RS10130
uniprot id: C6XWV4
names: Similarity
messages: Belongs to the histone deacetylase family.

485917:PHEP RS09420
gene id: 485917:PHEP_RS09420
uniprot id: C6XW22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

485917:PHEP RS02510
gene id: 485917:PHEP_RS02510
uniprot id: C6Y0G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS20380
gene id: 485917:PHEP_RS20380
uniprot id: C6XWJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

485917:PHEP RS03860
gene id: 485917:PHEP_RS03860
uniprot id: C6Y1L7
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS08150
gene id: 485917:PHEP_RS08150
uniprot id: C6XUJ1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

485917:PHEP RS16780
gene id: 485917:PHEP_RS16780
uniprot id: C6XSK4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS10290
gene id: 485917:PHEP_RS10290
uniprot id: C6XWY7
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

485917:PHEP RS17205
gene id: 485917:PHEP_RS17205
uniprot id: C6XST7
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS02415
gene id: 485917:PHEP_RS02415
uniprot id: C6Y011
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS05965
gene id: 485917:PHEP_RS05965
uniprot id: C6XS64
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

485917:PHEP RS06670
gene id: 485917:PHEP_RS06670
uniprot id: C6XSY8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

485917:PHEP RS03030
gene id: 485917:PHEP_RS03030
uniprot id: C6Y0R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

485917:PHEP RS15015
gene id: 485917:PHEP_RS15015
uniprot id: C6Y2L5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485917:PHEP RS04875
gene id: 485917:PHEP_RS04875
uniprot id: C6Y2Y2
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS15895
gene id: 485917:PHEP_RS15895
uniprot id: C6Y3G5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

485917:PHEP RS13600
gene id: 485917:PHEP_RS13600
uniprot id: C6Y120
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

485917:PHEP RS16590
gene id: 485917:PHEP_RS16590
uniprot id: C6Y486
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS19625
gene id: 485917:PHEP_RS19625
uniprot id: C6XVQ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

485917:PHEP RS06440
gene id: 485917:PHEP_RS06440
uniprot id: C6XSF8
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS19845
gene id: 485917:PHEP_RS19845
uniprot id: C6XVU5
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.

485917:PHEP RS03555
gene id: 485917:PHEP_RS03555
uniprot id: C6Y1F7
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS04445
gene id: 485917:PHEP_RS04445
uniprot id: C6Y2B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell inner membrane
messages: Membrane
messages: Transport of potassium into the cell.

485917:PHEP RS01155
gene id: 485917:PHEP_RS01155
uniprot id: C6XYX6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS11055
gene id: 485917:PHEP_RS11055
uniprot id: C6XY15
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

485917:PHEP RS14335
gene id: 485917:PHEP_RS14335
uniprot id: C6Y1U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS17275
gene id: 485917:PHEP_RS17275
uniprot id: C6XSV1
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS03805
gene id: 485917:PHEP_RS03805
uniprot id: C6Y1K6
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS20295
gene id: 485917:PHEP_RS20295
uniprot id: C6XWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

485917:PHEP RS06060
gene id: 485917:PHEP_RS06060
uniprot id: C6XS84
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS04115
gene id: 485917:PHEP_RS04115
uniprot id: C6Y251
names: Similarity
messages: Belongs to the Lgt family.

485917:PHEP RS10340
gene id: 485917:PHEP_RS10340
uniprot id: C6XWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

485917:PHEP RS16470
gene id: 485917:PHEP_RS16470
uniprot id: C6Y462
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

485917:PHEP RS13995
gene id: 485917:PHEP_RS13995
uniprot id: C6Y1N3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS05945
gene id: 485917:PHEP_RS05945
uniprot id: C6XS60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS14485
gene id: 485917:PHEP_RS14485
uniprot id: C6Y1X8
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

485917:PHEP RS09290
gene id: 485917:PHEP_RS09290
uniprot id: C6XVZ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

485917:PHEP RS17055
gene id: 485917:PHEP_RS17055
uniprot id: C6XSQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

485917:PHEP RS04750
gene id: 485917:PHEP_RS04750
uniprot id: C6Y2V7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS18055
gene id: 485917:PHEP_RS18055
uniprot id: C6XU16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

485917:PHEP RS17185
gene id: 485917:PHEP_RS17185
uniprot id: C6XST3
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS20300
gene id: 485917:PHEP_RS20300
uniprot id: C6XWH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Membrane

485917:PHEP RS16460
gene id: 485917:PHEP_RS16460
uniprot id: C6Y460
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

485917:PHEP RS02030
gene id: 485917:PHEP_RS02030
uniprot id: C6XZT6
names: Similarity
messages: Belongs to the ComB family.

485917:PHEP RS06885
gene id: 485917:PHEP_RS06885
uniprot id: C6XT29
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS10570
gene id: 485917:PHEP_RS10570
uniprot id: C6XXR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

485917:PHEP RS00750
gene id: 485917:PHEP_RS00750
uniprot id: C6XYA8
names: Similarity
messages: Belongs to the glycosyltransferase 10 family.

485917:PHEP RS08620
gene id: 485917:PHEP_RS08620
uniprot id: C6XV67
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

485917:PHEP RS11850
gene id: 485917:PHEP_RS11850
uniprot id: C6XYW2
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS15905
gene id: 485917:PHEP_RS15905
uniprot id: C6Y3G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

485917:PHEP RS14380
gene id: 485917:PHEP_RS14380
uniprot id: C6Y1V7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

485917:PHEP RS17500
gene id: 485917:PHEP_RS17500
uniprot id: C6XTC9
names: Similarity
messages: Belongs to the peptidase M16 family.

485917:PHEP RS10180
gene id: 485917:PHEP_RS10180
uniprot id: C6XWW4
names: Similarity
messages: Belongs to the citrate synthase family.

485917:PHEP RS19115
gene id: 485917:PHEP_RS19115
uniprot id: C6XV15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

485917:PHEP RS01110
gene id: 485917:PHEP_RS01110
uniprot id: C6XYI2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

485917:PHEP RS03300
gene id: 485917:PHEP_RS03300
uniprot id: C6Y1A6
names: Subcellular Location Annotation
messages: Mitochondrion

485917:PHEP RS12655
gene id: 485917:PHEP_RS12655
uniprot id: C6Y045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS07100
gene id: 485917:PHEP_RS07100
uniprot id: C6XT74
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

485917:PHEP RS18820
gene id: 485917:PHEP_RS18820
uniprot id: C6XUV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS00120
gene id: 485917:PHEP_RS00120
uniprot id: C6XXJ6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS11685
gene id: 485917:PHEP_RS11685
uniprot id: C6XYS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

485917:PHEP RS19520
gene id: 485917:PHEP_RS19520
uniprot id: C6XVN0
names: Similarity
messages: In the N-terminal section; belongs to the phytochrome family.

485917:PHEP RS06305
gene id: 485917:PHEP_RS06305
uniprot id: C6XSD3
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

485917:PHEP RS15280
gene id: 485917:PHEP_RS15280
uniprot id: C6Y2R1
names: Similarity
messages: Belongs to the peptidase S49 family.

485917:PHEP RS18035
gene id: 485917:PHEP_RS18035
uniprot id: C6XU12
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

485917:PHEP RS14555
gene id: 485917:PHEP_RS14555
uniprot id: C6Y1Z2
names: Similarity
messages: Belongs to the Lgt family.

485917:PHEP RS19680
gene id: 485917:PHEP_RS19680
uniprot id: C6XVR2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

485917:PHEP RS17530
gene id: 485917:PHEP_RS17530
uniprot id: C6XTD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

485917:PHEP RS16890
gene id: 485917:PHEP_RS16890
uniprot id: C6XSM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

485917:PHEP RS19865
gene id: 485917:PHEP_RS19865
uniprot id: C6XVU9
names: Function
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.
messages: Belongs to the cellobiose 2-epimerase family.
messages: Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).

485917:PHEP RS14660
gene id: 485917:PHEP_RS14660
uniprot id: C6Y2E5
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS05960
gene id: 485917:PHEP_RS05960
uniprot id: C6XS63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

485917:PHEP RS15355
gene id: 485917:PHEP_RS15355
uniprot id: C6Y360
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

485917:PHEP RS03660
gene id: 485917:PHEP_RS03660
uniprot id: C6Y1H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS13415
gene id: 485917:PHEP_RS13415
uniprot id: C6Y0Y3
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS02065
gene id: 485917:PHEP_RS02065
uniprot id: C6XZU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

485917:PHEP RS15080
gene id: 485917:PHEP_RS15080
uniprot id: C6Y2M8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

485917:PHEP RS09475
gene id: 485917:PHEP_RS09475
uniprot id: C6XW33
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS01480
gene id: 485917:PHEP_RS01480
uniprot id: C6XZ39
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS12755
gene id: 485917:PHEP_RS12755
uniprot id: C6Y064
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

485917:PHEP RS15310
gene id: 485917:PHEP_RS15310
uniprot id: C6Y352
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS00090
gene id: 485917:PHEP_RS00090
uniprot id: C6XXJ0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

485917:PHEP RS00800
gene id: 485917:PHEP_RS00800
uniprot id: C6XYB9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

485917:PHEP RS14770
gene id: 485917:PHEP_RS14770
uniprot id: C6Y2G6
names: Similarity
messages: Belongs to the AIR synthase family.

485917:PHEP RS13495
gene id: 485917:PHEP_RS13495
uniprot id: C6Y0Z9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS15260
gene id: 485917:PHEP_RS15260
uniprot id: C6Y2Q7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS15635
gene id: 485917:PHEP_RS15635
uniprot id: C6Y3B4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS20635
gene id: 485917:PHEP_RS20635
uniprot id: C6XWP0
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS13915
gene id: 485917:PHEP_RS13915
uniprot id: C6Y182
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS19040
gene id: 485917:PHEP_RS19040
uniprot id: C6XV00
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

485917:PHEP RS15190
gene id: 485917:PHEP_RS15190
uniprot id: C6Y2P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

485917:PHEP RS14885
gene id: 485917:PHEP_RS14885
uniprot id: C6Y2I9
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

485917:PHEP RS05125
gene id: 485917:PHEP_RS05125
uniprot id: C6Y331
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS17285
gene id: 485917:PHEP_RS17285
uniprot id: C6XSV3
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS02555
gene id: 485917:PHEP_RS02555
uniprot id: C6Y0H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

485917:PHEP RS13655
gene id: 485917:PHEP_RS13655
uniprot id: C6Y131
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS02380
gene id: 485917:PHEP_RS02380
uniprot id: C6Y004
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

485917:PHEP RS03530
gene id: 485917:PHEP_RS03530
uniprot id: C6Y1F2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

485917:PHEP RS03150
gene id: 485917:PHEP_RS03150
uniprot id: C6Y0U0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

485917:PHEP RS15485
gene id: 485917:PHEP_RS15485
uniprot id: C6Y386
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS10055
gene id: 485917:PHEP_RS10055
uniprot id: C6XWT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS02675
gene id: 485917:PHEP_RS02675
uniprot id: C6Y0J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

485917:PHEP RS15560
gene id: 485917:PHEP_RS15560
uniprot id: C6Y3A0
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS21010
gene id: 485917:PHEP_RS21010
uniprot id: C6XX98
names: Similarity
messages: Belongs to the UPF0173 family.

485917:PHEP RS19550
gene id: 485917:PHEP_RS19550
uniprot id: C6XVN6
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

485917:PHEP RS01265
gene id: 485917:PHEP_RS01265
uniprot id: C6XYZ7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS15030
gene id: 485917:PHEP_RS15030
uniprot id: C6Y2L8
names: Similarity
messages: Belongs to the LOG family.

485917:PHEP RS10835
gene id: 485917:PHEP_RS10835
uniprot id: C6XXX1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

485917:PHEP RS00550
gene id: 485917:PHEP_RS00550
uniprot id: C6XY69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

485917:PHEP RS09495
gene id: 485917:PHEP_RS09495
uniprot id: C6XW37
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

485917:PHEP RS14395
gene id: 485917:PHEP_RS14395
uniprot id: C6Y1W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

485917:PHEP RS02655
gene id: 485917:PHEP_RS02655
uniprot id: C6Y0J3
names: Subcellular Location Annotation
messages: Cytoplasm

485917:PHEP RS12420
gene id: 485917:PHEP_RS12420
uniprot id: C6XZL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

485917:PHEP RS08220
gene id: 485917:PHEP_RS08220
uniprot id: C6XUK5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

485917:PHEP RS20270
gene id: 485917:PHEP_RS20270
uniprot id: C6XWG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

485917:PHEP RS18520
gene id: 485917:PHEP_RS18520
uniprot id: C6XUB0
names: Cofactor
messages: Binds 1 zinc ion per subunit.

485917:PHEP RS03510
gene id: 485917:PHEP_RS03510
uniprot id: C6Y1E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

485917:PHEP RS07555
gene id: 485917:PHEP_RS07555
uniprot id: C6XTT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

485917:PHEP RS20015
gene id: 485917:PHEP_RS20015
uniprot id: C6XVX9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS03145
gene id: 485917:PHEP_RS03145
uniprot id: C6Y0T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

485917:PHEP RS09050
gene id: 485917:PHEP_RS09050
uniprot id: C6XVF9
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS01210
gene id: 485917:PHEP_RS01210
uniprot id: C6XYY7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

485917:PHEP RS15390
gene id: 485917:PHEP_RS15390
uniprot id: C6Y367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

485917:PHEP RS09250
gene id: 485917:PHEP_RS09250
uniprot id: C6XVY6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS08550
gene id: 485917:PHEP_RS08550
uniprot id: C6XUR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS10295
gene id: 485917:PHEP_RS10295
uniprot id: C6XWY8
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

485917:PHEP RS21290
gene id: 485917:PHEP_RS21290
uniprot id: C6XXF4
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

485917:PHEP RS12260
gene id: 485917:PHEP_RS12260
uniprot id: C6XZI1
names: Similarity
messages: Belongs to the CvfB family.

485917:PHEP RS06075
gene id: 485917:PHEP_RS06075
uniprot id: C6XS87
names: Similarity
messages: Belongs to the YciI family.

485917:PHEP RS13935
gene id: 485917:PHEP_RS13935
uniprot id: C6Y1M1
names: Similarity
messages: Belongs to the DapA family.

485917:PHEP RS16815
gene id: 485917:PHEP_RS16815
uniprot id: C6XSL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS07290
gene id: 485917:PHEP_RS07290
uniprot id: C6XTN6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS11395
gene id: 485917:PHEP_RS11395
uniprot id: C6XYM0
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS20685
gene id: 485917:PHEP_RS20685
uniprot id: C6XWQ0
names: Similarity
messages: Belongs to the fabD family.

485917:PHEP RS18495
gene id: 485917:PHEP_RS18495
uniprot id: C6XUA5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS11655
gene id: 485917:PHEP_RS11655
uniprot id: C6XYS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS08375
gene id: 485917:PHEP_RS08375
uniprot id: C6XUN5
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

485917:PHEP RS18880
gene id: 485917:PHEP_RS18880
uniprot id: C6XUW6
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

485917:PHEP RS16380
gene id: 485917:PHEP_RS16380
uniprot id: C6Y444
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS16905
gene id: 485917:PHEP_RS16905
uniprot id: C6XSM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS01315
gene id: 485917:PHEP_RS01315
uniprot id: C6XZ07
names: Similarity
messages: Belongs to the arginase family.

485917:PHEP RS02885
gene id: 485917:PHEP_RS02885
uniprot id: C6Y0N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

485917:PHEP RS11885
gene id: 485917:PHEP_RS11885
uniprot id: C6XYX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm

485917:PHEP RS16205
gene id: 485917:PHEP_RS16205
uniprot id: C6Y409
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS00565
gene id: 485917:PHEP_RS00565
uniprot id: C6XY72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

485917:PHEP RS13005
gene id: 485917:PHEP_RS13005
uniprot id: C6Y0B7
names: Similarity
messages: Belongs to the peptidase C56 family.

485917:PHEP RS00940
gene id: 485917:PHEP_RS00940
uniprot id: C6XYE7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS03895
gene id: 485917:PHEP_RS03895
uniprot id: C6Y207
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

485917:PHEP RS17540
gene id: 485917:PHEP_RS17540
uniprot id: C6XTD9
names: Similarity
messages: Belongs to the BshC family.

485917:PHEP RS10595
gene id: 485917:PHEP_RS10595
uniprot id: C6XXS1
names: Similarity
messages: Belongs to the aldose epimerase family.

485917:PHEP RS18885
gene id: 485917:PHEP_RS18885
uniprot id: C6XUW7
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

485917:PHEP RS15550
gene id: 485917:PHEP_RS15550
uniprot id: C6Y398
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS05730
gene id: 485917:PHEP_RS05730
uniprot id: C6Y3T9
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

485917:PHEP RS17060
gene id: 485917:PHEP_RS17060
uniprot id: C6XSQ8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

485917:PHEP RS19970
gene id: 485917:PHEP_RS19970
uniprot id: C6XVX0
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

485917:PHEP RS05550
gene id: 485917:PHEP_RS05550
uniprot id: C6Y3Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS13295
gene id: 485917:PHEP_RS13295
uniprot id: C6Y0V8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS02830
gene id: 485917:PHEP_RS02830
uniprot id: C6Y0M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS00185
gene id: 485917:PHEP_RS00185
uniprot id: C6XXK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

485917:PHEP RS07210
gene id: 485917:PHEP_RS07210
uniprot id: C6XT95
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

485917:PHEP RS01755
gene id: 485917:PHEP_RS01755
uniprot id: C6XZ94
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

485917:PHEP RS02095
gene id: 485917:PHEP_RS02095
uniprot id: C6XZU9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

485917:PHEP RS03450
gene id: 485917:PHEP_RS03450
uniprot id: C6Y1D6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

485917:PHEP RS07385
gene id: 485917:PHEP_RS07385
uniprot id: C6XTQ4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS04950
gene id: 485917:PHEP_RS04950
uniprot id: C6Y2Z7
names: Similarity
messages: Belongs to the Skp family.

485917:PHEP RS17655
gene id: 485917:PHEP_RS17655
uniprot id: C6XTG2
names: Similarity
messages: Belongs to the ribF family.

485917:PHEP RS11605
gene id: 485917:PHEP_RS11605
uniprot id: C6XYR3
names: Similarity
messages: Belongs to the MQO family.

485917:PHEP RS01140
gene id: 485917:PHEP_RS01140
uniprot id: C6XYX3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

485917:PHEP RS21340
gene id: 485917:PHEP_RS21340
uniprot id: C6XXG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

485917:PHEP RS02995
gene id: 485917:PHEP_RS02995
uniprot id: C6Y0Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

485917:PHEP RS12085
gene id: 485917:PHEP_RS12085
uniprot id: C6XZE6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS16870
gene id: 485917:PHEP_RS16870
uniprot id: C6XSM1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS03215
gene id: 485917:PHEP_RS03215
uniprot id: C6Y188
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS15320
gene id: 485917:PHEP_RS15320
uniprot id: C6Y354
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

485917:PHEP RS12800
gene id: 485917:PHEP_RS12800
uniprot id: C6Y074
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

485917:PHEP RS12630
gene id: 485917:PHEP_RS12630
uniprot id: C6Y040
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485917:PHEP RS13335
gene id: 485917:PHEP_RS13335
uniprot id: C6Y0W7
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

485917:PHEP RS05040
gene id: 485917:PHEP_RS05040
uniprot id: C6Y314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS03585
gene id: 485917:PHEP_RS03585
uniprot id: C6Y1G3
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

485917:PHEP RS16885
gene id: 485917:PHEP_RS16885
uniprot id: C6XSM4
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS03130
gene id: 485917:PHEP_RS03130
uniprot id: C6Y0T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

485917:PHEP RS04325
gene id: 485917:PHEP_RS04325
uniprot id: C6Y288
names: Similarity
messages: Belongs to the HSP15 family.

485917:PHEP RS01190
gene id: 485917:PHEP_RS01190
uniprot id: C6XYY3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

485917:PHEP RS02985
gene id: 485917:PHEP_RS02985
uniprot id: C6Y0Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

485917:PHEP RS00560
gene id: 485917:PHEP_RS00560
uniprot id: C6XY71
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

485917:PHEP RS16755
gene id: 485917:PHEP_RS16755
uniprot id: C6XSJ9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS00155
gene id: 485917:PHEP_RS00155
uniprot id: C6XXK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

485917:PHEP RS08490
gene id: 485917:PHEP_RS08490
uniprot id: C6XUQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS08570
gene id: 485917:PHEP_RS08570
uniprot id: C6XUS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

485917:PHEP RS07750
gene id: 485917:PHEP_RS07750
uniprot id: C6XTX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

485917:PHEP RS00270
gene id: 485917:PHEP_RS00270
uniprot id: C6XXM6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS14010
gene id: 485917:PHEP_RS14010
uniprot id: C6Y1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS20290
gene id: 485917:PHEP_RS20290
uniprot id: C6XWH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

485917:PHEP RS06950
gene id: 485917:PHEP_RS06950
uniprot id: C6XT43
names: Similarity
messages: Belongs to the peptidase M1 family.

485917:PHEP RS07180
gene id: 485917:PHEP_RS07180
uniprot id: C6XT90
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

485917:PHEP RS07725
gene id: 485917:PHEP_RS07725
uniprot id: C6XTX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

485917:PHEP RS00060
gene id: 485917:PHEP_RS00060
uniprot id: C6XXI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

485917:PHEP RS07205
gene id: 485917:PHEP_RS07205
uniprot id: C6XT94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS03880
gene id: 485917:PHEP_RS03880
uniprot id: C6Y204
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.

485917:PHEP RS12890
gene id: 485917:PHEP_RS12890
uniprot id: C6Y093
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS21130
gene id: 485917:PHEP_RS21130
uniprot id: C6XXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

485917:PHEP RS20970
gene id: 485917:PHEP_RS20970
uniprot id: C6XX90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

485917:PHEP RS14065
gene id: 485917:PHEP_RS14065
uniprot id: C6Y1P7
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.

485917:PHEP RS20315
gene id: 485917:PHEP_RS20315
uniprot id: C6XWH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

485917:PHEP RS20950
gene id: 485917:PHEP_RS20950
uniprot id: C6XX86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

485917:PHEP RS02750
gene id: 485917:PHEP_RS02750
uniprot id: C6Y0L2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

485917:PHEP RS18250
gene id: 485917:PHEP_RS18250
uniprot id: C6XU56
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS21245
gene id: 485917:PHEP_RS21245
uniprot id: C6XXE5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS21105
gene id: 485917:PHEP_RS21105
uniprot id: C6XXB7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS06485
gene id: 485917:PHEP_RS06485
uniprot id: C6XSG7
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

485917:PHEP RS20385
gene id: 485917:PHEP_RS20385
uniprot id: C6XWJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

485917:PHEP RS18240
gene id: 485917:PHEP_RS18240
uniprot id: C6XU54
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS02495
gene id: 485917:PHEP_RS02495
uniprot id: C6Y027
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

485917:PHEP RS03835
gene id: 485917:PHEP_RS03835
uniprot id: C6Y1L2
names: Similarity
messages: Belongs to the DinB family.

485917:PHEP RS00630
gene id: 485917:PHEP_RS00630
uniprot id: C6XY84
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

485917:PHEP RS09815
gene id: 485917:PHEP_RS09815
uniprot id: C6XWA2
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS05380
gene id: 485917:PHEP_RS05380
uniprot id: C6Y3L4
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS11740
gene id: 485917:PHEP_RS11740
uniprot id: C6XYU0
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

485917:PHEP RS07695
gene id: 485917:PHEP_RS07695
uniprot id: C6XTW4
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

485917:PHEP RS21645
gene id: 485917:PHEP_RS21645
uniprot id: C6XZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

485917:PHEP RS06065
gene id: 485917:PHEP_RS06065
uniprot id: C6XS85
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

485917:PHEP RS05745
gene id: 485917:PHEP_RS05745
uniprot id: C6Y3U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS17595
gene id: 485917:PHEP_RS17595
uniprot id: C6XTF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485917:PHEP RS17850
gene id: 485917:PHEP_RS17850
uniprot id: C6XTK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS19260
gene id: 485917:PHEP_RS19260
uniprot id: C6XV45
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

485917:PHEP RS04350
gene id: 485917:PHEP_RS04350
uniprot id: C6Y293
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

485917:PHEP RS06710
gene id: 485917:PHEP_RS06710
uniprot id: C6XSZ6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS03400
gene id: 485917:PHEP_RS03400
uniprot id: C6Y1C6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS06105
gene id: 485917:PHEP_RS06105
uniprot id: C6XS93
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

485917:PHEP RS06600
gene id: 485917:PHEP_RS06600
uniprot id: C6XSX4
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

485917:PHEP RS12395
gene id: 485917:PHEP_RS12395
uniprot id: C6XZK9
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

485917:PHEP RS01450
gene id: 485917:PHEP_RS01450
uniprot id: C6XZ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

485917:PHEP RS04415
gene id: 485917:PHEP_RS04415
uniprot id: C6Y2A6
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

485917:PHEP RS06110
gene id: 485917:PHEP_RS06110
uniprot id: C6XS94
names: Similarity
messages: Belongs to the type IB topoisomerase family.

485917:PHEP RS03680
gene id: 485917:PHEP_RS03680
uniprot id: C6Y1I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

485917:PHEP RS15345
gene id: 485917:PHEP_RS15345
uniprot id: C6Y358
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

485917:PHEP RS18800
gene id: 485917:PHEP_RS18800
uniprot id: C6XUV2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

485917:PHEP RS06160
gene id: 485917:PHEP_RS06160
uniprot id: C6XSA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

485917:PHEP RS14565
gene id: 485917:PHEP_RS14565
uniprot id: C6Y1Z4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS11290
gene id: 485917:PHEP_RS11290
uniprot id: C6XYJ8
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

485917:PHEP RS03540
gene id: 485917:PHEP_RS03540
uniprot id: C6Y1F4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS17535
gene id: 485917:PHEP_RS17535
uniprot id: C6XTD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

485917:PHEP RS02340
gene id: 485917:PHEP_RS02340
uniprot id: C6XZZ7
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS02640
gene id: 485917:PHEP_RS02640
uniprot id: C6Y0J0
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

485917:PHEP RS06325
gene id: 485917:PHEP_RS06325
uniprot id: C6XSD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

485917:PHEP RS03045
gene id: 485917:PHEP_RS03045
uniprot id: C6Y0R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

485917:PHEP RS11195
gene id: 485917:PHEP_RS11195
uniprot id: C6XY43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

485917:PHEP RS02195
gene id: 485917:PHEP_RS02195
uniprot id: C6XZW9
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS00330
gene id: 485917:PHEP_RS00330
uniprot id: C6XXN8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

485917:PHEP RS06905
gene id: 485917:PHEP_RS06905
uniprot id: C6XT34
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS02630
gene id: 485917:PHEP_RS02630
uniprot id: C6Y0I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS05595
gene id: 485917:PHEP_RS05595
uniprot id: C6Y3R1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS05670
gene id: 485917:PHEP_RS05670
uniprot id: C6Y3S7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

485917:PHEP RS16750
gene id: 485917:PHEP_RS16750
uniprot id: C6XSJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS02265
gene id: 485917:PHEP_RS02265
uniprot id: C6XZY3
names: Similarity
messages: Belongs to the bacterial phospholipase C family.

485917:PHEP RS11200
gene id: 485917:PHEP_RS11200
uniprot id: C6XY44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS07220
gene id: 485917:PHEP_RS07220
uniprot id: C6XT97
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

485917:PHEP RS11305
gene id: 485917:PHEP_RS11305
uniprot id: C6XYK1
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS02845
gene id: 485917:PHEP_RS02845
uniprot id: C6Y0N0
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

485917:PHEP RS03615
gene id: 485917:PHEP_RS03615
uniprot id: C6Y1G9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS00650
gene id: 485917:PHEP_RS00650
uniprot id: C6XY88
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

485917:PHEP RS01400
gene id: 485917:PHEP_RS01400
uniprot id: C6XZ23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

485917:PHEP RS20245
gene id: 485917:PHEP_RS20245
uniprot id: C6XWG2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS05685
gene id: 485917:PHEP_RS05685
uniprot id: C6Y3T0
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

485917:PHEP RS10930
gene id: 485917:PHEP_RS10930
uniprot id: C6XXZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS13620
gene id: 485917:PHEP_RS13620
uniprot id: C6Y124
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS16315
gene id: 485917:PHEP_RS16315
uniprot id: C6Y431
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

485917:PHEP RS09155
gene id: 485917:PHEP_RS09155
uniprot id: C6XVI1
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

485917:PHEP RS12365
gene id: 485917:PHEP_RS12365
uniprot id: C6XZK3
names: Similarity
messages: Belongs to the SCO1/2 family.

485917:PHEP RS03010
gene id: 485917:PHEP_RS03010
uniprot id: C6Y0R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS00655
gene id: 485917:PHEP_RS00655
uniprot id: C6XY89
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS16065
gene id: 485917:PHEP_RS16065
uniprot id: C6Y3Y1
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

485917:PHEP RS19135
gene id: 485917:PHEP_RS19135
uniprot id: C6XV19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

485917:PHEP RS00570
gene id: 485917:PHEP_RS00570
uniprot id: C6XY73
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

485917:PHEP RS07755
gene id: 485917:PHEP_RS07755
uniprot id: C6XTX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

485917:PHEP RS16545
gene id: 485917:PHEP_RS16545
uniprot id: C6Y477
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS06025
gene id: 485917:PHEP_RS06025
uniprot id: C6XS76
names: Similarity
messages: Belongs to the Fur family.

485917:PHEP RS20935
gene id: 485917:PHEP_RS20935
uniprot id: C6XX83
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

485917:PHEP RS10240
gene id: 485917:PHEP_RS10240
uniprot id: C6XWX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

485917:PHEP RS20700
gene id: 485917:PHEP_RS20700
uniprot id: C6XWQ3
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).

485917:PHEP RS20570
gene id: 485917:PHEP_RS20570
uniprot id: C6XWM7
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS19545
gene id: 485917:PHEP_RS19545
uniprot id: C6XVN5
names: Similarity
messages: Belongs to the polysaccharide synthase family.

485917:PHEP RS18940
gene id: 485917:PHEP_RS18940
uniprot id: C6XUX8
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS18080
gene id: 485917:PHEP_RS18080
uniprot id: C6XU21
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

485917:PHEP RS04265
gene id: 485917:PHEP_RS04265
uniprot id: C6Y276
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

485917:PHEP RS12860
gene id: 485917:PHEP_RS12860
uniprot id: C6Y087
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS02570
gene id: 485917:PHEP_RS02570
uniprot id: C6Y0H6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

485917:PHEP RS07785
gene id: 485917:PHEP_RS07785
uniprot id: C6XTY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

485917:PHEP RS20345
gene id: 485917:PHEP_RS20345
uniprot id: C6XWI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

485917:PHEP RS16585
gene id: 485917:PHEP_RS16585
uniprot id: C6Y485
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

485917:PHEP RS04985
gene id: 485917:PHEP_RS04985
uniprot id: C6Y303
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS06395
gene id: 485917:PHEP_RS06395
uniprot id: C6XSE9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS10975
gene id: 485917:PHEP_RS10975
uniprot id: C6XXZ9
names: Similarity
messages: Belongs to the DapA family.

485917:PHEP RS00110
gene id: 485917:PHEP_RS00110
uniprot id: C6XXJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

485917:PHEP RS13195
gene id: 485917:PHEP_RS13195
uniprot id: C6Y0F3
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

485917:PHEP RS10720
gene id: 485917:PHEP_RS10720
uniprot id: C6XXU7
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS04990
gene id: 485917:PHEP_RS04990
uniprot id: C6Y304
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS03085
gene id: 485917:PHEP_RS03085
uniprot id: C6Y0S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

485917:PHEP RS13530
gene id: 485917:PHEP_RS13530
uniprot id: C6Y106
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS16165
gene id: 485917:PHEP_RS16165
uniprot id: C6Y401
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS14295
gene id: 485917:PHEP_RS14295
uniprot id: C6Y1U1
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

485917:PHEP RS17445
gene id: 485917:PHEP_RS17445
uniprot id: C6XTB9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS20045
gene id: 485917:PHEP_RS20045
uniprot id: C6XWC1
names: Similarity
messages: Belongs to the UxaA family.

485917:PHEP RS12240
gene id: 485917:PHEP_RS12240
uniprot id: C6XZH7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS18260
gene id: 485917:PHEP_RS18260
uniprot id: C6XU58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS07105
gene id: 485917:PHEP_RS07105
uniprot id: C6XT75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS19020
gene id: 485917:PHEP_RS19020
uniprot id: C6XUZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

485917:PHEP RS15775
gene id: 485917:PHEP_RS15775
uniprot id: C6Y3E1
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS10315
gene id: 485917:PHEP_RS10315
uniprot id: C6XWZ1
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS03925
gene id: 485917:PHEP_RS03925
uniprot id: C6Y213
names: Function
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.
messages: Broad-specificity glycosaminoglycan lyase.

485917:PHEP RS09360
gene id: 485917:PHEP_RS09360
uniprot id: C6XW09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

485917:PHEP RS09900
gene id: 485917:PHEP_RS09900
uniprot id: C6XWC0
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS00815
gene id: 485917:PHEP_RS00815
uniprot id: C6XYC2
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

485917:PHEP RS10310
gene id: 485917:PHEP_RS10310
uniprot id: C6XWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS00555
gene id: 485917:PHEP_RS00555
uniprot id: C6XY70
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

485917:PHEP RS13455
gene id: 485917:PHEP_RS13455
uniprot id: C6Y0Z1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS20320
gene id: 485917:PHEP_RS20320
uniprot id: C6XWH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

485917:PHEP RS07025
gene id: 485917:PHEP_RS07025
uniprot id: C6XT58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

485917:PHEP RS16325
gene id: 485917:PHEP_RS16325
uniprot id: C6Y433
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS20600
gene id: 485917:PHEP_RS20600
uniprot id: C6XWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS18105
gene id: 485917:PHEP_RS18105
uniprot id: C6XU26
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS00830
gene id: 485917:PHEP_RS00830
uniprot id: C6XYC5
names: Similarity
messages: Belongs to the peptidase S41A family.

485917:PHEP RS01530
gene id: 485917:PHEP_RS01530
uniprot id: C6XZ49
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS20895
gene id: 485917:PHEP_RS20895
uniprot id: C6XX75
names: Similarity
messages: Belongs to the pyruvate kinase family.

485917:PHEP RS02695
gene id: 485917:PHEP_RS02695
uniprot id: C6Y0K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

485917:PHEP RS16600
gene id: 485917:PHEP_RS16600
uniprot id: C6Y488
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

485917:PHEP RS12400
gene id: 485917:PHEP_RS12400
uniprot id: C6XZL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

485917:PHEP RS14765
gene id: 485917:PHEP_RS14765
uniprot id: C6Y2G5
names: Similarity
messages: Belongs to the glutamine synthetase family.

485917:PHEP RS09335
gene id: 485917:PHEP_RS09335
uniprot id: C6XW04
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

485917:PHEP RS19170
gene id: 485917:PHEP_RS19170
uniprot id: C6XV26
names: Similarity
messages: Belongs to the acylphosphatase family.

485917:PHEP RS18815
gene id: 485917:PHEP_RS18815
uniprot id: C6XUV5
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS15365
gene id: 485917:PHEP_RS15365
uniprot id: C6Y362
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS14540
gene id: 485917:PHEP_RS14540
uniprot id: C6Y1Y9
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

485917:PHEP RS12535
gene id: 485917:PHEP_RS12535
uniprot id: C6XZN7
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS15875
gene id: 485917:PHEP_RS15875
uniprot id: C6Y3G1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

485917:PHEP RS09230
gene id: 485917:PHEP_RS09230
uniprot id: C6XVJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

485917:PHEP RS10725
gene id: 485917:PHEP_RS10725
uniprot id: C6XXU8
names: Subunit
messages: Homodimer.

485917:PHEP RS20280
gene id: 485917:PHEP_RS20280
uniprot id: C6XWG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

485917:PHEP RS14110
gene id: 485917:PHEP_RS14110
uniprot id: C6Y1Q7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS17160
gene id: 485917:PHEP_RS17160
uniprot id: C6XSS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS04040
gene id: 485917:PHEP_RS04040
uniprot id: C6Y236
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

485917:PHEP RS03275
gene id: 485917:PHEP_RS03275
uniprot id: C6Y1A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

485917:PHEP RS07015
gene id: 485917:PHEP_RS07015
uniprot id: C6XT56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

485917:PHEP RS05875
gene id: 485917:PHEP_RS05875
uniprot id: C6Y3W2
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

485917:PHEP RS19975
gene id: 485917:PHEP_RS19975
uniprot id: C6XVX1
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS09820
gene id: 485917:PHEP_RS09820
uniprot id: C6XWA3
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS18345
gene id: 485917:PHEP_RS18345
uniprot id: C6XU75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS01275
gene id: 485917:PHEP_RS01275
uniprot id: C6XYZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS06385
gene id: 485917:PHEP_RS06385
uniprot id: C6XSE7
names: Similarity
messages: Belongs to the DinB family.

485917:PHEP RS18780
gene id: 485917:PHEP_RS18780
uniprot id: C6XUU8
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS00495
gene id: 485917:PHEP_RS00495
uniprot id: C6XY58
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS15930
gene id: 485917:PHEP_RS15930
uniprot id: C6Y3H2
names: Similarity
messages: Belongs to the universal stress protein A family.

485917:PHEP RS12485
gene id: 485917:PHEP_RS12485
uniprot id: C6XZM8
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS06970
gene id: 485917:PHEP_RS06970
uniprot id: C6XT47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

485917:PHEP RS15645
gene id: 485917:PHEP_RS15645
uniprot id: C6Y3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS18510
gene id: 485917:PHEP_RS18510
uniprot id: C6XUA8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

485917:PHEP RS05855
gene id: 485917:PHEP_RS05855
uniprot id: C6Y3V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

485917:PHEP RS05085
gene id: 485917:PHEP_RS05085
uniprot id: C6Y323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS03885
gene id: 485917:PHEP_RS03885
uniprot id: C6Y205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS11560
gene id: 485917:PHEP_RS11560
uniprot id: C6XYQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

485917:PHEP RS21195
gene id: 485917:PHEP_RS21195
uniprot id: C6XXD5
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS18440
gene id: 485917:PHEP_RS18440
uniprot id: C6XU94
names: Similarity
messages: Belongs to the pirin family.

485917:PHEP RS12745
gene id: 485917:PHEP_RS12745
uniprot id: C6Y062
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS03070
gene id: 485917:PHEP_RS03070
uniprot id: C6Y0S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

485917:PHEP RS20355
gene id: 485917:PHEP_RS20355
uniprot id: C6XWI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

485917:PHEP RS09675
gene id: 485917:PHEP_RS09675
uniprot id: C6XW73
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

485917:PHEP RS09240
gene id: 485917:PHEP_RS09240
uniprot id: C6XVJ7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS19305
gene id: 485917:PHEP_RS19305
uniprot id: C6XV54
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS20905
gene id: 485917:PHEP_RS20905
uniprot id: C6XX77
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

485917:PHEP RS20770
gene id: 485917:PHEP_RS20770
uniprot id: C6XX50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

485917:PHEP RS01065
gene id: 485917:PHEP_RS01065
uniprot id: C6XYH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

485917:PHEP RS10125
gene id: 485917:PHEP_RS10125
uniprot id: C6XWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0187 family.
messages: Membrane

485917:PHEP RS20335
gene id: 485917:PHEP_RS20335
uniprot id: C6XWI0
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

485917:PHEP RS21370
gene id: 485917:PHEP_RS21370
uniprot id: C6XXH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

485917:PHEP RS18355
gene id: 485917:PHEP_RS18355
uniprot id: C6XU77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

485917:PHEP RS16915
gene id: 485917:PHEP_RS16915
uniprot id: C6XSN0
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS00660
gene id: 485917:PHEP_RS00660
uniprot id: C6XY90
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS14445
gene id: 485917:PHEP_RS14445
uniprot id: C6Y1X0
names: Similarity
messages: Belongs to the Dps family.

485917:PHEP RS06435
gene id: 485917:PHEP_RS06435
uniprot id: C6XSF7
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.

485917:PHEP RS00850
gene id: 485917:PHEP_RS00850
uniprot id: C6XYC9
names: Similarity
messages: Belongs to the peptidase C40 family.

485917:PHEP RS18570
gene id: 485917:PHEP_RS18570
uniprot id: C6XUC0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485917:PHEP RS12245
gene id: 485917:PHEP_RS12245
uniprot id: C6XZH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

485917:PHEP RS15605
gene id: 485917:PHEP_RS15605
uniprot id: C6Y3A9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS07090
gene id: 485917:PHEP_RS07090
uniprot id: C6XT72
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

485917:PHEP RS04890
gene id: 485917:PHEP_RS04890
uniprot id: C6Y2Y5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

485917:PHEP RS18155
gene id: 485917:PHEP_RS18155
uniprot id: C6XU36
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

485917:PHEP RS04085
gene id: 485917:PHEP_RS04085
uniprot id: C6Y245
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS09325
gene id: 485917:PHEP_RS09325
uniprot id: C6XW02
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

485917:PHEP RS17695
gene id: 485917:PHEP_RS17695
uniprot id: C6XTH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

485917:PHEP RS20170
gene id: 485917:PHEP_RS20170
uniprot id: C6XWE6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS10575
gene id: 485917:PHEP_RS10575
uniprot id: C6XXR7
names: Similarity
messages: Belongs to the glutamate synthase family.

485917:PHEP RS19775
gene id: 485917:PHEP_RS19775
uniprot id: C6XVT1
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS14550
gene id: 485917:PHEP_RS14550
uniprot id: C6Y1Z1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

485917:PHEP RS15060
gene id: 485917:PHEP_RS15060
uniprot id: C6Y2M4
names: Similarity
messages: Belongs to the SufE family.

485917:PHEP RS18855
gene id: 485917:PHEP_RS18855
uniprot id: C6XUW1
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

485917:PHEP RS11155
gene id: 485917:PHEP_RS11155
uniprot id: C6XY35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS01495
gene id: 485917:PHEP_RS01495
uniprot id: C6XZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS06685
gene id: 485917:PHEP_RS06685
uniprot id: C6XSZ1
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS00880
gene id: 485917:PHEP_RS00880
uniprot id: C6XYD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS14330
gene id: 485917:PHEP_RS14330
uniprot id: C6Y1U8
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS07700
gene id: 485917:PHEP_RS07700
uniprot id: C6XTW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

485917:PHEP RS02565
gene id: 485917:PHEP_RS02565
uniprot id: C6Y0H5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS17565
gene id: 485917:PHEP_RS17565
uniprot id: C6XTE4
names: Similarity
messages: Belongs to the ParB family.

485917:PHEP RS10730
gene id: 485917:PHEP_RS10730
uniprot id: C6XXU9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

485917:PHEP RS12790
gene id: 485917:PHEP_RS12790
uniprot id: C6Y072
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS05500
gene id: 485917:PHEP_RS05500
uniprot id: C6Y3P1
names: Similarity
messages: Belongs to the GSP E family.

485917:PHEP RS20060
gene id: 485917:PHEP_RS20060
uniprot id: C6XWC4
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

485917:PHEP RS17340
gene id: 485917:PHEP_RS17340
uniprot id: C6XSW3
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS06680
gene id: 485917:PHEP_RS06680
uniprot id: C6XSZ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS20195
gene id: 485917:PHEP_RS20195
uniprot id: C6XWF1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485917:PHEP RS03125
gene id: 485917:PHEP_RS03125
uniprot id: C6Y0T4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

485917:PHEP RS07380
gene id: 485917:PHEP_RS07380
uniprot id: C6XTQ3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS07560
gene id: 485917:PHEP_RS07560
uniprot id: C6XTT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485917:PHEP RS08385
gene id: 485917:PHEP_RS08385
uniprot id: C6XUN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

485917:PHEP RS17200
gene id: 485917:PHEP_RS17200
uniprot id: C6XST6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

485917:PHEP RS05940
gene id: 485917:PHEP_RS05940
uniprot id: C6XS59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

485917:PHEP RS00700
gene id: 485917:PHEP_RS00700
uniprot id: C6XY98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

485917:PHEP RS07670
gene id: 485917:PHEP_RS07670
uniprot id: C6XTV9
names: Similarity
messages: Belongs to the sigma-54 factor family.

485917:PHEP RS20650
gene id: 485917:PHEP_RS20650
uniprot id: C6XWP3
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

485917:PHEP RS07590
gene id: 485917:PHEP_RS07590
uniprot id: C6XTU5
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS18015
gene id: 485917:PHEP_RS18015
uniprot id: C6XTM3
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS08210
gene id: 485917:PHEP_RS08210
uniprot id: C6XUK3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

485917:PHEP RS17070
gene id: 485917:PHEP_RS17070
uniprot id: C6XSR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

485917:PHEP RS16495
gene id: 485917:PHEP_RS16495
uniprot id: C6Y467
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS10535
gene id: 485917:PHEP_RS10535
uniprot id: C6XX33
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS00675
gene id: 485917:PHEP_RS00675
uniprot id: C6XY93
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

485917:PHEP RS00925
gene id: 485917:PHEP_RS00925
uniprot id: C6XYE4
names: Similarity
messages: Belongs to the DEAD box helicase family.

485917:PHEP RS14475
gene id: 485917:PHEP_RS14475
uniprot id: C6Y1X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

485917:PHEP RS04945
gene id: 485917:PHEP_RS04945
uniprot id: C6Y2Z6
names: Similarity
messages: Belongs to the Skp family.

485917:PHEP RS09190
gene id: 485917:PHEP_RS09190
uniprot id: C6XVI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

485917:PHEP RS13835
gene id: 485917:PHEP_RS13835
uniprot id: C6Y166
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS14070
gene id: 485917:PHEP_RS14070
uniprot id: C6Y1P8
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

485917:PHEP RS20330
gene id: 485917:PHEP_RS20330
uniprot id: C6XWH9
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

485917:PHEP RS10430
gene id: 485917:PHEP_RS10430
uniprot id: C6XX13
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

485917:PHEP RS01800
gene id: 485917:PHEP_RS01800
uniprot id: C6XZA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

485917:PHEP RS15650
gene id: 485917:PHEP_RS15650
uniprot id: C6Y3B7
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

485917:PHEP RS02220
gene id: 485917:PHEP_RS02220
uniprot id: C6XZX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS18865
gene id: 485917:PHEP_RS18865
uniprot id: C6XUW3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

485917:PHEP RS01930
gene id: 485917:PHEP_RS01930
uniprot id: C6XZR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

485917:PHEP RS18950
gene id: 485917:PHEP_RS18950
uniprot id: Q59289
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 12 family.
messages: Periplasm
messages: Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.

485917:PHEP RS18995
gene id: 485917:PHEP_RS18995
uniprot id: C6XUZ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS18330
gene id: 485917:PHEP_RS18330
uniprot id: C6XU72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

485917:PHEP RS16295
gene id: 485917:PHEP_RS16295
uniprot id: C6Y427
names: Similarity
messages: Belongs to the peptidase C40 family.

485917:PHEP RS17745
gene id: 485917:PHEP_RS17745
uniprot id: C6XTH9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS10605
gene id: 485917:PHEP_RS10605
uniprot id: C6XXS3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS11110
gene id: 485917:PHEP_RS11110
uniprot id: C6XY26
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS03135
gene id: 485917:PHEP_RS03135
uniprot id: C6Y0T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

485917:PHEP RS05180
gene id: 485917:PHEP_RS05180
uniprot id: C6Y342
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS12770
gene id: 485917:PHEP_RS12770
uniprot id: C6Y068
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

485917:PHEP RS13695
gene id: 485917:PHEP_RS13695
uniprot id: C6Y139
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS19875
gene id: 485917:PHEP_RS19875
uniprot id: C6XVV1
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS04280
gene id: 485917:PHEP_RS04280
uniprot id: C6Y279
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

485917:PHEP RS01890
gene id: 485917:PHEP_RS01890
uniprot id: C6XZQ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485917:PHEP RS02325
gene id: 485917:PHEP_RS02325
uniprot id: C6XZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS16085
gene id: 485917:PHEP_RS16085
uniprot id: C6Y3Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS09445
gene id: 485917:PHEP_RS09445
uniprot id: C6XW27
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS07770
gene id: 485917:PHEP_RS07770
uniprot id: C6XTY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell inner membrane
messages: H(+)-stimulated, divalent metal cation uptake system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS11145
gene id: 485917:PHEP_RS11145
uniprot id: C6XY33
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS05850
gene id: 485917:PHEP_RS05850
uniprot id: C6Y3V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

485917:PHEP RS07065
gene id: 485917:PHEP_RS07065
uniprot id: C6XT67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

485917:PHEP RS20955
gene id: 485917:PHEP_RS20955
uniprot id: C6XX87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

485917:PHEP RS08965
gene id: 485917:PHEP_RS08965
uniprot id: C6XVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS01420
gene id: 485917:PHEP_RS01420
uniprot id: C6XZ27
names: Similarity
messages: Belongs to the UPF0162 family.

485917:PHEP RS20020
gene id: 485917:PHEP_RS20020
uniprot id: C6XVY0
names: Similarity
messages: Belongs to the peptidase M24B family.

485917:PHEP RS20540
gene id: 485917:PHEP_RS20540
uniprot id: C6XWM1
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS18040
gene id: 485917:PHEP_RS18040
uniprot id: C6XU13
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

485917:PHEP RS02300
gene id: 485917:PHEP_RS02300
uniprot id: C6XZY8
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

485917:PHEP RS05950
gene id: 485917:PHEP_RS05950
uniprot id: C6XS61
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS07825
gene id: 485917:PHEP_RS07825
uniprot id: C6XTZ1
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

485917:PHEP RS03670
gene id: 485917:PHEP_RS03670
uniprot id: C6Y1I0
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

485917:PHEP RS19685
gene id: 485917:PHEP_RS19685
uniprot id: C6XVR3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

485917:PHEP RS20275
gene id: 485917:PHEP_RS20275
uniprot id: C6XWG8
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS07800
gene id: 485917:PHEP_RS07800
uniprot id: C6XTY6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS17300
gene id: 485917:PHEP_RS17300
uniprot id: C6XSV6
names: Similarity
messages: Belongs to the DEAD box helicase family.

485917:PHEP RS02310
gene id: 485917:PHEP_RS02310
uniprot id: C6XZZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 1618 of 23S rRNA.

485917:PHEP RS00210
gene id: 485917:PHEP_RS00210
uniprot id: C6XXL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

485917:PHEP RS03055
gene id: 485917:PHEP_RS03055
uniprot id: C6Y0S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

485917:PHEP RS14310
gene id: 485917:PHEP_RS14310
uniprot id: C6Y1U4
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

485917:PHEP RS10395
gene id: 485917:PHEP_RS10395
uniprot id: C6XX06
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

485917:PHEP RS04955
gene id: 485917:PHEP_RS04955
uniprot id: C6Y2Z8
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

485917:PHEP RS11910
gene id: 485917:PHEP_RS11910
uniprot id: C6XZB1
names: Similarity
messages: Belongs to the UPF0047 family.

485917:PHEP RS13355
gene id: 485917:PHEP_RS13355
uniprot id: C6Y0X1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

485917:PHEP RS16730
gene id: 485917:PHEP_RS16730
uniprot id: C6XSJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS15025
gene id: 485917:PHEP_RS15025
uniprot id: C6Y2L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS03475
gene id: 485917:PHEP_RS03475
uniprot id: C6Y1E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

485917:PHEP RS13605
gene id: 485917:PHEP_RS13605
uniprot id: C6Y121
names: Similarity
messages: Belongs to the RuBisCO large chain family.

485917:PHEP RS10380
gene id: 485917:PHEP_RS10380
uniprot id: C6XX04
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

485917:PHEP RS15475
gene id: 485917:PHEP_RS15475
uniprot id: C6Y384
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS15005
gene id: 485917:PHEP_RS15005
uniprot id: C6Y2L3
names: Similarity
messages: Belongs to the TrpF family.

485917:PHEP RS08025
gene id: 485917:PHEP_RS08025
uniprot id: C6XUG7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

485917:PHEP RS02850
gene id: 485917:PHEP_RS02850
uniprot id: C6Y0N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS16190
gene id: 485917:PHEP_RS16190
uniprot id: C6Y406
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS17995
gene id: 485917:PHEP_RS17995
uniprot id: C6XTL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

485917:PHEP RS13990
gene id: 485917:PHEP_RS13990
uniprot id: C6Y1N2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS04340
gene id: 485917:PHEP_RS04340
uniprot id: C6Y291
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

485917:PHEP RS17680
gene id: 485917:PHEP_RS17680
uniprot id: C6XTG7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS15135
gene id: 485917:PHEP_RS15135
uniprot id: C6Y2N5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485917:PHEP RS09455
gene id: 485917:PHEP_RS09455
uniprot id: C6XW29
names: Similarity
messages: Belongs to the serpin family.

485917:PHEP RS11335
gene id: 485917:PHEP_RS11335
uniprot id: C6XYK7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS05830
gene id: 485917:PHEP_RS05830
uniprot id: C6Y3V3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS01970
gene id: 485917:PHEP_RS01970
uniprot id: C6XZS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

485917:PHEP RS07520
gene id: 485917:PHEP_RS07520
uniprot id: C6XTT0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS11220
gene id: 485917:PHEP_RS11220
uniprot id: C6XY48
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

485917:PHEP RS21040
gene id: 485917:PHEP_RS21040
uniprot id: C6XXA4
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

485917:PHEP RS12195
gene id: 485917:PHEP_RS12195
uniprot id: C6XZG9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS17690
gene id: 485917:PHEP_RS17690
uniprot id: C6XTG9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

485917:PHEP RS05635
gene id: 485917:PHEP_RS05635
uniprot id: C6Y3S0
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

485917:PHEP RS05375
gene id: 485917:PHEP_RS05375
uniprot id: C6Y3L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS22430
gene id: 485917:PHEP_RS22430
uniprot id: C6Y489
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485917:PHEP RS19010
gene id: 485917:PHEP_RS19010
uniprot id: C6XUZ3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

485917:PHEP RS16030
gene id: 485917:PHEP_RS16030
uniprot id: C6Y3X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Membrane

485917:PHEP RS07160
gene id: 485917:PHEP_RS07160
uniprot id: C6XT86
names: Similarity
messages: Belongs to the DprA/Smf family.

485917:PHEP RS12875
gene id: 485917:PHEP_RS12875
uniprot id: C6Y090
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS07820
gene id: 485917:PHEP_RS07820
uniprot id: C6XTZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

485917:PHEP RS05655
gene id: 485917:PHEP_RS05655
uniprot id: C6Y3S4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

485917:PHEP RS13080
gene id: 485917:PHEP_RS13080
uniprot id: C6Y0D2
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

485917:PHEP RS12340
gene id: 485917:PHEP_RS12340
uniprot id: C6XZJ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS14830
gene id: 485917:PHEP_RS14830
uniprot id: C6Y2H7
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS11165
gene id: 485917:PHEP_RS11165
uniprot id: C6XY37
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS15885
gene id: 485917:PHEP_RS15885
uniprot id: C6Y3G3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

485917:PHEP RS07910
gene id: 485917:PHEP_RS07910
uniprot id: C6XU08
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

485917:PHEP RS16945
gene id: 485917:PHEP_RS16945
uniprot id: C6XSN6
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS20410
gene id: 485917:PHEP_RS20410
uniprot id: C6XWJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

485917:PHEP RS05825
gene id: 485917:PHEP_RS05825
uniprot id: C6Y3V2
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

485917:PHEP RS13505
gene id: 485917:PHEP_RS13505
uniprot id: C6Y101
names: Similarity
messages: Belongs to the aldose epimerase family.

485917:PHEP RS01795
gene id: 485917:PHEP_RS01795
uniprot id: C6XZA2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

485917:PHEP RS11675
gene id: 485917:PHEP_RS11675
uniprot id: C6XYS8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS06705
gene id: 485917:PHEP_RS06705
uniprot id: C6XSZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

485917:PHEP RS03855
gene id: 485917:PHEP_RS03855
uniprot id: C6Y1L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS02465
gene id: 485917:PHEP_RS02465
uniprot id: C6Y021
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

485917:PHEP RS16225
gene id: 485917:PHEP_RS16225
uniprot id: C6Y413
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

485917:PHEP RS00645
gene id: 485917:PHEP_RS00645
uniprot id: C6XY87
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

485917:PHEP RS12820
gene id: 485917:PHEP_RS12820
uniprot id: C6Y078
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS00485
gene id: 485917:PHEP_RS00485
uniprot id: C6XY56
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

485917:PHEP RS00390
gene id: 485917:PHEP_RS00390
uniprot id: C6XXQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

485917:PHEP RS07905
gene id: 485917:PHEP_RS07905
uniprot id: C6XU07
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

485917:PHEP RS04335
gene id: 485917:PHEP_RS04335
uniprot id: C6Y290
names: Similarity
messages: Belongs to the Skp family.

485917:PHEP RS09405
gene id: 485917:PHEP_RS09405
uniprot id: C6XW19
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485917:PHEP RS11040
gene id: 485917:PHEP_RS11040
uniprot id: C6XY12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS11475
gene id: 485917:PHEP_RS11475
uniprot id: C6XYN7
names: Similarity
messages: Belongs to the IlvD/Edd family.

485917:PHEP RS05905
gene id: 485917:PHEP_RS05905
uniprot id: C6XS52
names: Similarity
messages: Belongs to the bacterial phospholipase C family.

485917:PHEP RS06810
gene id: 485917:PHEP_RS06810
uniprot id: C6XT15
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS10265
gene id: 485917:PHEP_RS10265
uniprot id: C6XWY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

485917:PHEP RS03140
gene id: 485917:PHEP_RS03140
uniprot id: C6Y0T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

485917:PHEP RS20095
gene id: 485917:PHEP_RS20095
uniprot id: C6XWD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS11495
gene id: 485917:PHEP_RS11495
uniprot id: C6XYP1
names: Similarity
messages: Belongs to the arginase family.

485917:PHEP RS15795
gene id: 485917:PHEP_RS15795
uniprot id: C6Y3E5
names: Function
names: Similarity
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.

485917:PHEP RS09315
gene id: 485917:PHEP_RS09315
uniprot id: C6XW00
names: Similarity
messages: Belongs to the CinA family.

485917:PHEP RS11625
gene id: 485917:PHEP_RS11625
uniprot id: C6XYR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS07990
gene id: 485917:PHEP_RS07990
uniprot id: C6XUG0
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS09380
gene id: 485917:PHEP_RS09380
uniprot id: C6XW13
names: Similarity
messages: Belongs to the peptidase C40 family.

485917:PHEP RS06825
gene id: 485917:PHEP_RS06825
uniprot id: C6XT18
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS10145
gene id: 485917:PHEP_RS10145
uniprot id: C6XWV7
names: Similarity
messages: Belongs to the peptidase S58 family.

485917:PHEP RS12780
gene id: 485917:PHEP_RS12780
uniprot id: C6Y070
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

485917:PHEP RS11530
gene id: 485917:PHEP_RS11530
uniprot id: C6XYP8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

485917:PHEP RS04005
gene id: 485917:PHEP_RS04005
uniprot id: C6Y229
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

485917:PHEP RS06640
gene id: 485917:PHEP_RS06640
uniprot id: C6XSY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS16005
gene id: 485917:PHEP_RS16005
uniprot id: C6Y3W9
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

485917:PHEP RS12505
gene id: 485917:PHEP_RS12505
uniprot id: C6XZN2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

485917:PHEP RS08125
gene id: 485917:PHEP_RS08125
uniprot id: C6XUI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

485917:PHEP RS08070
gene id: 485917:PHEP_RS08070
uniprot id: C6XUH6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

485917:PHEP RS20985
gene id: 485917:PHEP_RS20985
uniprot id: C6XX93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

485917:PHEP RS12565
gene id: 485917:PHEP_RS12565
uniprot id: C6XZP3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

485917:PHEP RS00860
gene id: 485917:PHEP_RS00860
uniprot id: C6XYD1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

485917:PHEP RS20715
gene id: 485917:PHEP_RS20715
uniprot id: C6XX39
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS07850
gene id: 485917:PHEP_RS07850
uniprot id: C6XTZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

485917:PHEP RS16105
gene id: 485917:PHEP_RS16105
uniprot id: C6Y3Y9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS09500
gene id: 485917:PHEP_RS09500
uniprot id: C6XW38
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

485917:PHEP RS19060
gene id: 485917:PHEP_RS19060
uniprot id: C6XV04
names: Similarity
messages: Belongs to the LacAB/RpiB family.

485917:PHEP RS14620
gene id: 485917:PHEP_RS14620
uniprot id: C6Y2D7
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS00790
gene id: 485917:PHEP_RS00790
uniprot id: C6XYB7
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

485917:PHEP RS06415
gene id: 485917:PHEP_RS06415
uniprot id: C6XSF3
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS19230
gene id: 485917:PHEP_RS19230
uniprot id: C6XV38
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

485917:PHEP RS10235
gene id: 485917:PHEP_RS10235
uniprot id: C6XWX5
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

485917:PHEP RS18910
gene id: 485917:PHEP_RS18910
uniprot id: C6XUX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS18245
gene id: 485917:PHEP_RS18245
uniprot id: C6XU55
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS17605
gene id: 485917:PHEP_RS17605
uniprot id: C6XTF2
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS19890
gene id: 485917:PHEP_RS19890
uniprot id: C6XVV4
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS09370
gene id: 485917:PHEP_RS09370
uniprot id: C6XW11
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

485917:PHEP RS16820
gene id: 485917:PHEP_RS16820
uniprot id: C6XSL2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485917:PHEP RS00775
gene id: 485917:PHEP_RS00775
uniprot id: C6XYB3
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

485917:PHEP RS06630
gene id: 485917:PHEP_RS06630
uniprot id: C6XSY0
names: Subunit
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

485917:PHEP RS04045
gene id: 485917:PHEP_RS04045
uniprot id: C6Y237
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

485917:PHEP RS18265
gene id: 485917:PHEP_RS18265
uniprot id: C6XU59
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS02430
gene id: 485917:PHEP_RS02430
uniprot id: C6Y014
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS21360
gene id: 485917:PHEP_RS21360
uniprot id: C6XXG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

485917:PHEP RS13775
gene id: 485917:PHEP_RS13775
uniprot id: C6Y154
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485917:PHEP RS17005
gene id: 485917:PHEP_RS17005
uniprot id: C6XSP7
names: Similarity
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

485917:PHEP RS05990
gene id: 485917:PHEP_RS05990
uniprot id: C6XS69
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

485917:PHEP RS06990
gene id: 485917:PHEP_RS06990
uniprot id: C6XT51
names: Subcellular Location Annotation
messages: Nucleus

485917:PHEP RS14595
gene id: 485917:PHEP_RS14595
uniprot id: C6Y200
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

485917:PHEP RS01435
gene id: 485917:PHEP_RS01435
uniprot id: C6XZ30
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

485917:PHEP RS08880
gene id: 485917:PHEP_RS08880
uniprot id: C6XVC6
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS13475
gene id: 485917:PHEP_RS13475
uniprot id: C6Y0Z5
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS15965
gene id: 485917:PHEP_RS15965
uniprot id: C6Y3H9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

485917:PHEP RS02615
gene id: 485917:PHEP_RS02615
uniprot id: C6Y0I5
names: Similarity
messages: Belongs to the DapA family.

485917:PHEP RS14415
gene id: 485917:PHEP_RS14415
uniprot id: C6Y1W4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

485917:PHEP RS07145
gene id: 485917:PHEP_RS07145
uniprot id: C6XT83
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS07230
gene id: 485917:PHEP_RS07230
uniprot id: C6XT99
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS07120
gene id: 485917:PHEP_RS07120
uniprot id: C6XT78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

485917:PHEP RS11835
gene id: 485917:PHEP_RS11835
uniprot id: C6XYV9
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS06570
gene id: 485917:PHEP_RS06570
uniprot id: C6XSW8
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

485917:PHEP RS20860
gene id: 485917:PHEP_RS20860
uniprot id: C6XX68
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

485917:PHEP RS17135
gene id: 485917:PHEP_RS17135
uniprot id: C6XSS3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

485917:PHEP RS20200
gene id: 485917:PHEP_RS20200
uniprot id: C6XWF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS02305
gene id: 485917:PHEP_RS02305
uniprot id: C6XZY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

485917:PHEP RS17740
gene id: 485917:PHEP_RS17740
uniprot id: C6XTH8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS03430
gene id: 485917:PHEP_RS03430
uniprot id: C6Y1D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

485917:PHEP RS20305
gene id: 485917:PHEP_RS20305
uniprot id: C6XWH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

485917:PHEP RS02350
gene id: 485917:PHEP_RS02350
uniprot id: C6XZZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

485917:PHEP RS00710
gene id: 485917:PHEP_RS00710
uniprot id: C6XYA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

485917:PHEP RS04130
gene id: 485917:PHEP_RS04130
uniprot id: C6Y254
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

485917:PHEP RS16580
gene id: 485917:PHEP_RS16580
uniprot id: C6Y484
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

485917:PHEP RS11320
gene id: 485917:PHEP_RS11320
uniprot id: C6XYK4
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS09615
gene id: 485917:PHEP_RS09615
uniprot id: C6XW61
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS03695
gene id: 485917:PHEP_RS03695
uniprot id: C6Y1I5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

485917:PHEP RS15890
gene id: 485917:PHEP_RS15890
uniprot id: C6Y3G4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS00580
gene id: 485917:PHEP_RS00580
uniprot id: C6XY75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

485917:PHEP RS20690
gene id: 485917:PHEP_RS20690
uniprot id: C6XWQ1
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

485917:PHEP RS01380
gene id: 485917:PHEP_RS01380
uniprot id: C6XZ19
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

485917:PHEP RS12955
gene id: 485917:PHEP_RS12955
uniprot id: C6Y0A5
names: Similarity
messages: Belongs to the FPG family.

485917:PHEP RS08450
gene id: 485917:PHEP_RS08450
uniprot id: C6XUP9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

485917:PHEP RS04270
gene id: 485917:PHEP_RS04270
uniprot id: C6Y277
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

485917:PHEP RS02410
gene id: 485917:PHEP_RS02410
uniprot id: C6Y010
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

485917:PHEP RS01960
gene id: 485917:PHEP_RS01960
uniprot id: C6XZS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

485917:PHEP RS10565
gene id: 485917:PHEP_RS10565
uniprot id: C6XXR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

485917:PHEP RS00865
gene id: 485917:PHEP_RS00865
uniprot id: C6XYD2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS16280
gene id: 485917:PHEP_RS16280
uniprot id: C6Y424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

485917:PHEP RS16610
gene id: 485917:PHEP_RS16610
uniprot id: C6Y490
names: Cofactor
messages: Binds 1 zinc ion per subunit.

485917:PHEP RS08020
gene id: 485917:PHEP_RS08020
uniprot id: C6XUG6
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS06590
gene id: 485917:PHEP_RS06590
uniprot id: C6XSX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485917:PHEP RS05620
gene id: 485917:PHEP_RS05620
uniprot id: C6Y3R7
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS18205
gene id: 485917:PHEP_RS18205
uniprot id: C6XU47
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.

485917:PHEP RS04375
gene id: 485917:PHEP_RS04375
uniprot id: C6Y298
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS16550
gene id: 485917:PHEP_RS16550
uniprot id: C6Y478
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS20150
gene id: 485917:PHEP_RS20150
uniprot id: C6XWE2
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS19905
gene id: 485917:PHEP_RS19905
uniprot id: C6XVV7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS17015
gene id: 485917:PHEP_RS17015
uniprot id: C6XSP9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS10760
gene id: 485917:PHEP_RS10760
uniprot id: C6XXV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485917:PHEP RS13490
gene id: 485917:PHEP_RS13490
uniprot id: C6Y0Z8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS14300
gene id: 485917:PHEP_RS14300
uniprot id: C6Y1U2
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS04365
gene id: 485917:PHEP_RS04365
uniprot id: C6Y296
names: Similarity
messages: Belongs to the thioredoxin family.

485917:PHEP RS06005
gene id: 485917:PHEP_RS06005
uniprot id: C6XS72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

485917:PHEP RS12140
gene id: 485917:PHEP_RS12140
uniprot id: C6XZF8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

485917:PHEP RS03525
gene id: 485917:PHEP_RS03525
uniprot id: C6Y1F1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

485917:PHEP RS06645
gene id: 485917:PHEP_RS06645
uniprot id: C6XSY3
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS07095
gene id: 485917:PHEP_RS07095
uniprot id: C6XT73
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

485917:PHEP RS01220
gene id: 485917:PHEP_RS01220
uniprot id: C6XYY9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485917:PHEP RS04935
gene id: 485917:PHEP_RS04935
uniprot id: C6Y2Z4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

485917:PHEP RS19535
gene id: 485917:PHEP_RS19535
uniprot id: C6XVN3
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

485917:PHEP RS10250
gene id: 485917:PHEP_RS10250
uniprot id: C6XWX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS12225
gene id: 485917:PHEP_RS12225
uniprot id: C6XZH4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

485917:PHEP RS16290
gene id: 485917:PHEP_RS16290
uniprot id: C6Y426
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485917:PHEP RS06360
gene id: 485917:PHEP_RS06360
uniprot id: C6XSE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

485917:PHEP RS03185
gene id: 485917:PHEP_RS03185
uniprot id: C6Y0U7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

485917:PHEP RS08540
gene id: 485917:PHEP_RS08540
uniprot id: C6XUR7
names: Similarity
messages: Belongs to the glycosyl hydrolase.

485917:PHEP RS18605
gene id: 485917:PHEP_RS18605
uniprot id: C6XUC8
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

485917:PHEP RS10280
gene id: 485917:PHEP_RS10280
uniprot id: C6XWY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

485917:PHEP RS18610
gene id: 485917:PHEP_RS18610
uniprot id: C6XUC9
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

485917:PHEP RS01070
gene id: 485917:PHEP_RS01070
uniprot id: C6XYH3
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

485917:PHEP RS08180
gene id: 485917:PHEP_RS08180
uniprot id: C6XUJ7
names: Similarity
messages: Belongs to the UPF0234 family.

485917:PHEP RS02055
gene id: 485917:PHEP_RS02055
uniprot id: C6XZU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS17065
gene id: 485917:PHEP_RS17065
uniprot id: C6XSQ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS10800
gene id: 485917:PHEP_RS10800
uniprot id: C6XXW3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

485917:PHEP RS15150
gene id: 485917:PHEP_RS15150
uniprot id: C6Y2N8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS14640
gene id: 485917:PHEP_RS14640
uniprot id: C6Y2E1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

485917:PHEP RS00175
gene id: 485917:PHEP_RS00175
uniprot id: C6XXK7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

485917:PHEP RS19645
gene id: 485917:PHEP_RS19645
uniprot id: C6XVQ5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

485917:PHEP RS16170
gene id: 485917:PHEP_RS16170
uniprot id: C6Y402
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS09200
gene id: 485917:PHEP_RS09200
uniprot id: C6XVI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

485917:PHEP RS13910
gene id: 485917:PHEP_RS13910
uniprot id: C6Y181
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS04245
gene id: 485917:PHEP_RS04245
uniprot id: C6Y272
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

485917:PHEP RS00770
gene id: 485917:PHEP_RS00770
uniprot id: C6XYB2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

485917:PHEP RS21140
gene id: 485917:PHEP_RS21140
uniprot id: C6XXC4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

485917:PHEP RS08595
gene id: 485917:PHEP_RS08595
uniprot id: C6XUS8
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS04405
gene id: 485917:PHEP_RS04405
uniprot id: C6Y2A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS04185
gene id: 485917:PHEP_RS04185
uniprot id: C6Y265
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS21035
gene id: 485917:PHEP_RS21035
uniprot id: C6XXA3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS18860
gene id: 485917:PHEP_RS18860
uniprot id: C6XUW2
names: Similarity
messages: Belongs to the peptidase S41A family.

485917:PHEP RS03820
gene id: 485917:PHEP_RS03820
uniprot id: C6Y1K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS17895
gene id: 485917:PHEP_RS17895
uniprot id: C6XTK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS16660
gene id: 485917:PHEP_RS16660
uniprot id: C6Y4A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

485917:PHEP RS19420
gene id: 485917:PHEP_RS19420
uniprot id: C6XVL0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485917:PHEP RS13460
gene id: 485917:PHEP_RS13460
uniprot id: C6Y0Z2
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

485917:PHEP RS10195
gene id: 485917:PHEP_RS10195
uniprot id: C6XWW7
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

485917:PHEP RS09740
gene id: 485917:PHEP_RS09740
uniprot id: C6XW86
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS06965
gene id: 485917:PHEP_RS06965
uniprot id: C6XT46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

485917:PHEP RS21380
gene id: 485917:PHEP_RS21380
uniprot id: C6XXH2
names: Similarity
messages: Belongs to the peptidase S13 family.

485917:PHEP RS21045
gene id: 485917:PHEP_RS21045
uniprot id: C6XXA5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

485917:PHEP RS00505
gene id: 485917:PHEP_RS00505
uniprot id: C6XY60
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

485917:PHEP RS10765
gene id: 485917:PHEP_RS10765
uniprot id: C6XXV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

485917:PHEP RS17440
gene id: 485917:PHEP_RS17440
uniprot id: C6XTB8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

485917:PHEP RS15010
gene id: 485917:PHEP_RS15010
uniprot id: C6Y2L4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS13975
gene id: 485917:PHEP_RS13975
uniprot id: C6Y1M9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS07335
gene id: 485917:PHEP_RS07335
uniprot id: C6XTP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

485917:PHEP RS07115
gene id: 485917:PHEP_RS07115
uniprot id: C6XT77
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

485917:PHEP RS16365
gene id: 485917:PHEP_RS16365
uniprot id: C6Y441
names: Similarity
messages: Belongs to the threonine aldolase family.

485917:PHEP RS19320
gene id: 485917:PHEP_RS19320
uniprot id: C6XV57
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS21310
gene id: 485917:PHEP_RS21310
uniprot id: C6XXF8
names: Similarity
messages: Belongs to the arginase family.

485917:PHEP RS17550
gene id: 485917:PHEP_RS17550
uniprot id: C6XTE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

485917:PHEP RS20735
gene id: 485917:PHEP_RS20735
uniprot id: C6XX43
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

485917:PHEP RS16805
gene id: 485917:PHEP_RS16805
uniprot id: C6XSK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

485917:PHEP RS03170
gene id: 485917:PHEP_RS03170
uniprot id: C6Y0U4
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

485917:PHEP RS00065
gene id: 485917:PHEP_RS00065
uniprot id: C6XXI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

485917:PHEP RS03310
gene id: 485917:PHEP_RS03310
uniprot id: C6Y1A8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS15160
gene id: 485917:PHEP_RS15160
uniprot id: C6Y2P0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

485917:PHEP RS06275
gene id: 485917:PHEP_RS06275
uniprot id: C6XSC7
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS18120
gene id: 485917:PHEP_RS18120
uniprot id: C6XU29
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

485917:PHEP RS20215
gene id: 485917:PHEP_RS20215
uniprot id: C6XWF5
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

485917:PHEP RS17555
gene id: 485917:PHEP_RS17555
uniprot id: C6XTE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

485917:PHEP RS04670
gene id: 485917:PHEP_RS04670
uniprot id: C6Y2U1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

485917:PHEP RS02475
gene id: 485917:PHEP_RS02475
uniprot id: C6Y023
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

485917:PHEP RS06240
gene id: 485917:PHEP_RS06240
uniprot id: C6XSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

485917:PHEP RS16075
gene id: 485917:PHEP_RS16075
uniprot id: C6Y3Y3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

485917:PHEP RS11585
gene id: 485917:PHEP_RS11585
uniprot id: C6XYQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

485917:PHEP RS03705
gene id: 485917:PHEP_RS03705
uniprot id: C6Y1I7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

485917:PHEP RS17840
gene id: 485917:PHEP_RS17840
uniprot id: C6XTJ8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

485917:PHEP RS00625
gene id: 485917:PHEP_RS00625
uniprot id: C6XY83
names: Similarity
messages: Belongs to the CarB family.

485917:PHEP RS02320
gene id: 485917:PHEP_RS02320
uniprot id: C6XZZ2
names: Similarity
messages: Belongs to the DtxR/MntR family.

485917:PHEP RS17640
gene id: 485917:PHEP_RS17640
uniprot id: C6XTF9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS19390
gene id: 485917:PHEP_RS19390
uniprot id: C6XVK4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

485917:PHEP RS20575
gene id: 485917:PHEP_RS20575
uniprot id: C6XWM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS04255
gene id: 485917:PHEP_RS04255
uniprot id: C6Y274
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

485917:PHEP RS16825
gene id: 485917:PHEP_RS16825
uniprot id: C6XSL3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS02390
gene id: 485917:PHEP_RS02390
uniprot id: C6Y006
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

485917:PHEP RS17705
gene id: 485917:PHEP_RS17705
uniprot id: C6XTH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

485917:PHEP RS15900
gene id: 485917:PHEP_RS15900
uniprot id: C6Y3G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

485917:PHEP RS01965
gene id: 485917:PHEP_RS01965
uniprot id: C6XZS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

485917:PHEP RS19035
gene id: 485917:PHEP_RS19035
uniprot id: C6XUZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

485917:PHEP RS14975
gene id: 485917:PHEP_RS14975
uniprot id: C6Y2K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS17220
gene id: 485917:PHEP_RS17220
uniprot id: C6XSU0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485917:PHEP RS17810
gene id: 485917:PHEP_RS17810
uniprot id: C6XTJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS21325
gene id: 485917:PHEP_RS21325
uniprot id: C6XXG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

485917:PHEP RS08670
gene id: 485917:PHEP_RS08670
uniprot id: C6XV77
names: Subcellular Location Annotation
messages: Cytoplasm

485917:PHEP RS16360
gene id: 485917:PHEP_RS16360
uniprot id: C6Y440
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

485917:PHEP RS20055
gene id: 485917:PHEP_RS20055
uniprot id: C6XWC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

485917:PHEP RS07250
gene id: 485917:PHEP_RS07250
uniprot id: C6XTM8
names: Similarity
messages: Belongs to the nitroreductase family.

485917:PHEP RS10755
gene id: 485917:PHEP_RS10755
uniprot id: C6XXV4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

485917:PHEP RS19220
gene id: 485917:PHEP_RS19220
uniprot id: C6XV36
names: Similarity
messages: Belongs to the DinB family.

485917:PHEP RS03155
gene id: 485917:PHEP_RS03155
uniprot id: C6Y0U1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

485917:PHEP RS00170
gene id: 485917:PHEP_RS00170
uniprot id: C6XXK6
names: Similarity
messages: Belongs to the UPF0145 family.

485917:PHEP RS12760
gene id: 485917:PHEP_RS12760
uniprot id: C6Y065
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

485917:PHEP RS16770
gene id: 485917:PHEP_RS16770
uniprot id: C6XSK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS18235
gene id: 485917:PHEP_RS18235
uniprot id: C6XU53
names: Similarity
messages: Belongs to the peptidase S13 family.

485917:PHEP RS16320
gene id: 485917:PHEP_RS16320
uniprot id: C6Y432
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

485917:PHEP RS03060
gene id: 485917:PHEP_RS03060
uniprot id: C6Y0S1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

485917:PHEP RS09280
gene id: 485917:PHEP_RS09280
uniprot id: C6XVZ3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

485917:PHEP RS17395
gene id: 485917:PHEP_RS17395
uniprot id: C6XTA9
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS11565
gene id: 485917:PHEP_RS11565
uniprot id: C6XYQ5
names: Similarity
messages: Belongs to the aspartokinase family.

485917:PHEP RS14800
gene id: 485917:PHEP_RS14800
uniprot id: C6Y2H2
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

485917:PHEP RS05770
gene id: 485917:PHEP_RS05770
uniprot id: C6Y3U7
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

485917:PHEP RS13890
gene id: 485917:PHEP_RS13890
uniprot id: C6Y177
names: Similarity
messages: Belongs to the FGGY kinase family.

485917:PHEP RS04050
gene id: 485917:PHEP_RS04050
uniprot id: C6Y238
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

485917:PHEP RS11270
gene id: 485917:PHEP_RS11270
uniprot id: C6XYJ4
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS19690
gene id: 485917:PHEP_RS19690
uniprot id: C6XVR4
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS03220
gene id: 485917:PHEP_RS03220
uniprot id: C6Y189
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

485917:PHEP RS11570
gene id: 485917:PHEP_RS11570
uniprot id: C6XYQ6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

485917:PHEP RS20640
gene id: 485917:PHEP_RS20640
uniprot id: C6XWP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS18875
gene id: 485917:PHEP_RS18875
uniprot id: C6XUW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

485917:PHEP RS19750
gene id: 485917:PHEP_RS19750
uniprot id: C6XVS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

485917:PHEP RS03700
gene id: 485917:PHEP_RS03700
uniprot id: C6Y1I6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

485917:PHEP RS00045
gene id: 485917:PHEP_RS00045
uniprot id: C6XXI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

485917:PHEP RS06500
gene id: 485917:PHEP_RS06500
uniprot id: C6XSH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS11490
gene id: 485917:PHEP_RS11490
uniprot id: C6XYP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

485917:PHEP RS15040
gene id: 485917:PHEP_RS15040
uniprot id: C6Y2M0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

485917:PHEP RS03515
gene id: 485917:PHEP_RS03515
uniprot id: C6Y1E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

485917:PHEP RS01335
gene id: 485917:PHEP_RS01335
uniprot id: C6XZ10
names: Similarity
messages: Belongs to the GARS family.

485917:PHEP RS03115
gene id: 485917:PHEP_RS03115
uniprot id: C6Y0T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

485917:PHEP RS07765
gene id: 485917:PHEP_RS07765
uniprot id: C6XTX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

485917:PHEP RS01215
gene id: 485917:PHEP_RS01215
uniprot id: C6XYY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

485917:PHEP RS18415
gene id: 485917:PHEP_RS18415
uniprot id: C6XU89
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS14465
gene id: 485917:PHEP_RS14465
uniprot id: C6Y1X4
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

485917:PHEP RS19265
gene id: 485917:PHEP_RS19265
uniprot id: C6XV46
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.

485917:PHEP RS10810
gene id: 485917:PHEP_RS10810
uniprot id: C6XXW5
names: Similarity
messages: Belongs to the IMPACT family.

485917:PHEP RS04895
gene id: 485917:PHEP_RS04895
uniprot id: C6Y2Y6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

485917:PHEP RS05785
gene id: 485917:PHEP_RS05785
uniprot id: C6Y3V0
names: Similarity
messages: Belongs to the UxaA family.

485917:PHEP RS01975
gene id: 485917:PHEP_RS01975
uniprot id: C6XZS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

485917:PHEP RS11470
gene id: 485917:PHEP_RS11470
uniprot id: C6XYN6
names: Subcellular Location Annotation
messages: Cytoplasm

485917:PHEP RS18575
gene id: 485917:PHEP_RS18575
uniprot id: C6XUC1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

485917:PHEP RS05740
gene id: 485917:PHEP_RS05740
uniprot id: C6Y3U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485917:PHEP RS00100
gene id: 485917:PHEP_RS00100
uniprot id: C6XXJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

485917:PHEP RS04145
gene id: 485917:PHEP_RS04145
uniprot id: C6Y257
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

485917:PHEP RS14365
gene id: 485917:PHEP_RS14365
uniprot id: C6Y1V5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

485917:PHEP RS12970
gene id: 485917:PHEP_RS12970
uniprot id: C6Y0A8
names: Similarity
messages: Belongs to the AHA1 family.

485917:PHEP RS01040
gene id: 485917:PHEP_RS01040
uniprot id: C6XYG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485917:PHEP RS15790
gene id: 485917:PHEP_RS15790
uniprot id: C6Y3E4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS19105
gene id: 485917:PHEP_RS19105
uniprot id: C6XV13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

485917:PHEP RS03265
gene id: 485917:PHEP_RS03265
uniprot id: C6Y198
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

485917:PHEP RS11985
gene id: 485917:PHEP_RS11985
uniprot id: C6XZC6
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

485917:PHEP RS07280
gene id: 485917:PHEP_RS07280
uniprot id: C6XTN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

485917:PHEP RS14635
gene id: 485917:PHEP_RS14635
uniprot id: C6Y2E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

485917:PHEP RS20755
gene id: 485917:PHEP_RS20755
uniprot id: C6XX47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

485917:PHEP RS21200
gene id: 485917:PHEP_RS21200
uniprot id: C6XXD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485917:PHEP RS21275
gene id: 485917:PHEP_RS21275
uniprot id: C6XXF1
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

485917:PHEP RS20110
gene id: 485917:PHEP_RS20110
uniprot id: C6XWD4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

485917:PHEP RS06010
gene id: 485917:PHEP_RS06010
uniprot id: C6XS73
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

485917:PHEP RS07040
gene id: 485917:PHEP_RS07040
uniprot id: C6XT62
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS20980
gene id: 485917:PHEP_RS20980
uniprot id: C6XX92
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

485917:PHEP RS13265
gene id: 485917:PHEP_RS13265
uniprot id: C6Y0V2
names: Similarity
messages: Belongs to the UPF0111 family.

485917:PHEP RS00430
gene id: 485917:PHEP_RS00430
uniprot id: C6XXQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

485917:PHEP RS03095
gene id: 485917:PHEP_RS03095
uniprot id: C6Y0S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

485917:PHEP RS16425
gene id: 485917:PHEP_RS16425
uniprot id: C6Y453
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

485917:PHEP RS14500
gene id: 485917:PHEP_RS14500
uniprot id: C6Y1Y1
names: Similarity
messages: Belongs to the aspartokinase family.

485917:PHEP RS20930
gene id: 485917:PHEP_RS20930
uniprot id: C6XX82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

485917:PHEP RS15235
gene id: 485917:PHEP_RS15235
uniprot id: C6Y2Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

485917:PHEP RS00435
gene id: 485917:PHEP_RS00435
uniprot id: C6XXQ8
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

485917:PHEP RS11915
gene id: 485917:PHEP_RS11915
uniprot id: C6XZB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

485917:PHEP RS13205
gene id: 485917:PHEP_RS13205
uniprot id: C6Y0F5
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS21305
gene id: 485917:PHEP_RS21305
uniprot id: C6XXF7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

485917:PHEP RS19050
gene id: 485917:PHEP_RS19050
uniprot id: C6XV02
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

485917:PHEP RS19055
gene id: 485917:PHEP_RS19055
uniprot id: C6XV03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

485917:PHEP RS03120
gene id: 485917:PHEP_RS03120
uniprot id: C6Y0T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

485917:PHEP RS06190
gene id: 485917:PHEP_RS06190
uniprot id: C6XSB0
names: Similarity
messages: Belongs to the peptidase M13 family.

485917:PHEP RS14725
gene id: 485917:PHEP_RS14725
uniprot id: C6Y2F7
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

485917:PHEP RS13130
gene id: 485917:PHEP_RS13130
uniprot id: C6Y0E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

485917:PHEP RS17000
gene id: 485917:PHEP_RS17000
uniprot id: C6XSP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

485917:PHEP RS17525
gene id: 485917:PHEP_RS17525
uniprot id: C6XTD4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

485917:PHEP RS07835
gene id: 485917:PHEP_RS07835
uniprot id: C6XTZ3
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

485917:PHEP RS03445
gene id: 485917:PHEP_RS03445
uniprot id: C6Y1D5
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

485917:PHEP RS16175
gene id: 485917:PHEP_RS16175
uniprot id: C6Y403
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

485917:PHEP RS17715
gene id: 485917:PHEP_RS17715
uniprot id: C6XTH4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

485917:PHEP RS12725
gene id: 485917:PHEP_RS12725
uniprot id: C6Y058
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

485917:PHEP RS14515
gene id: 485917:PHEP_RS14515
uniprot id: C6Y1Y4
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

485917:PHEP RS16775
gene id: 485917:PHEP_RS16775
uniprot id: C6XSK3
names: Similarity
messages: Belongs to the SusD family.

485917:PHEP RS02085
gene id: 485917:PHEP_RS02085
uniprot id: C6XZU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

485917:PHEP RS09145
gene id: 485917:PHEP_RS09145
uniprot id: C6XVH9
names: Subcellular Location Annotation
messages: Membrane

485917:PHEP RS14910
gene id: 485917:PHEP_RS14910
uniprot id: C6Y2J4
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

485917:PHEP RS20350
gene id: 485917:PHEP_RS20350
uniprot id: C6XWI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

485917:PHEP RS13105
gene id: 485917:PHEP_RS13105
uniprot id: C6Y0D6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.