485914:HMUK RS09765
gene id: 485914:HMUK_RS09765
uniprot id: C7NW21
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

485914:HMUK RS00980
gene id: 485914:HMUK_RS00980
uniprot id: C7NWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS02915
gene id: 485914:HMUK_RS02915
uniprot id: C7NZ63
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS13355
gene id: 485914:HMUK_RS13355
uniprot id: C7P068
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

485914:HMUK RS08660
gene id: 485914:HMUK_RS08660
uniprot id: C7P4A1
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

485914:HMUK RS06295
gene id: 485914:HMUK_RS06295
uniprot id: C7P2X2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

485914:HMUK RS05490
gene id: 485914:HMUK_RS05490
uniprot id: C7P249
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS07650
gene id: 485914:HMUK_RS07650
uniprot id: C7P3P5
names: Similarity
messages: Belongs to the arginase family.

485914:HMUK RS10910
gene id: 485914:HMUK_RS10910
uniprot id: C7NXE1
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

485914:HMUK RS02715
gene id: 485914:HMUK_RS02715
uniprot id: C7NZ23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

485914:HMUK RS08550
gene id: 485914:HMUK_RS08550
uniprot id: C7P478
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

485914:HMUK RS05045
gene id: 485914:HMUK_RS05045
uniprot id: C7P1H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

485914:HMUK RS03760
gene id: 485914:HMUK_RS03760
uniprot id: C7P010
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS04030
gene id: 485914:HMUK_RS04030
uniprot id: C7P0J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

485914:HMUK RS11090
gene id: 485914:HMUK_RS11090
uniprot id: C7NXH9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

485914:HMUK RS06240
gene id: 485914:HMUK_RS06240
uniprot id: C7P2W1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

485914:HMUK RS02325
gene id: 485914:HMUK_RS02325
uniprot id: C7NYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

485914:HMUK RS16090
gene id: 485914:HMUK_RS16090
uniprot id: C7P525
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

485914:HMUK RS02745
gene id: 485914:HMUK_RS02745
uniprot id: C7NZ29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

485914:HMUK RS03145
gene id: 485914:HMUK_RS03145
uniprot id: C7NZA6
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

485914:HMUK RS05370
gene id: 485914:HMUK_RS05370
uniprot id: C7P223
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

485914:HMUK RS01340
gene id: 485914:HMUK_RS01340
uniprot id: C7NX65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

485914:HMUK RS13360
gene id: 485914:HMUK_RS13360
uniprot id: C7P069
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS10785
gene id: 485914:HMUK_RS10785
uniprot id: C7NXB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

485914:HMUK RS10850
gene id: 485914:HMUK_RS10850
uniprot id: C7NXC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485914:HMUK RS10825
gene id: 485914:HMUK_RS10825
uniprot id: C7NXC4
names: Similarity
messages: Belongs to the UPF0284 family.

485914:HMUK RS07805
gene id: 485914:HMUK_RS07805
uniprot id: C7P3S7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS13550
gene id: 485914:HMUK_RS13550
uniprot id: C7P0B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

485914:HMUK RS10790
gene id: 485914:HMUK_RS10790
uniprot id: C7NXB8
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.

485914:HMUK RS12690
gene id: 485914:HMUK_RS12690
uniprot id: C7NZG1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

485914:HMUK RS09425
gene id: 485914:HMUK_RS09425
uniprot id: C7P4Q7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

485914:HMUK RS04915
gene id: 485914:HMUK_RS04915
uniprot id: C7P1F1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

485914:HMUK RS05410
gene id: 485914:HMUK_RS05410
uniprot id: C7P232
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

485914:HMUK RS13590
gene id: 485914:HMUK_RS13590
uniprot id: C7P0B8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

485914:HMUK RS13860
gene id: 485914:HMUK_RS13860
uniprot id: C7P0V2
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS09965
gene id: 485914:HMUK_RS09965
uniprot id: C7NW57
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

485914:HMUK RS02870
gene id: 485914:HMUK_RS02870
uniprot id: C7NZ54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

485914:HMUK RS11425
gene id: 485914:HMUK_RS11425
uniprot id: C7NY20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

485914:HMUK RS08805
gene id: 485914:HMUK_RS08805
uniprot id: C7P4D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

485914:HMUK RS14570
gene id: 485914:HMUK_RS14570
uniprot id: C7P1M1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS16030
gene id: 485914:HMUK_RS16030
uniprot id: C7P514
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS12745
gene id: 485914:HMUK_RS12745
uniprot id: C7NZH1
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

485914:HMUK RS00925
gene id: 485914:HMUK_RS00925
uniprot id: C7NWX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS03710
gene id: 485914:HMUK_RS03710
uniprot id: C7NZZ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

485914:HMUK RS01075
gene id: 485914:HMUK_RS01075
uniprot id: C7NX07
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

485914:HMUK RS03090
gene id: 485914:HMUK_RS03090
uniprot id: C7NZ99
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

485914:HMUK RS08285
gene id: 485914:HMUK_RS08285
uniprot id: C7P425
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

485914:HMUK RS04465
gene id: 485914:HMUK_RS04465
uniprot id: C7P0T6
names: Similarity
messages: Belongs to the RutC family.

485914:HMUK RS05170
gene id: 485914:HMUK_RS05170
uniprot id: C7P1Y2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS07325
gene id: 485914:HMUK_RS07325
uniprot id: C7P3H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

485914:HMUK RS08605
gene id: 485914:HMUK_RS08605
uniprot id: C7P489
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS07995
gene id: 485914:HMUK_RS07995
uniprot id: C7P3W6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS03065
gene id: 485914:HMUK_RS03065
uniprot id: C7NZ94
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

485914:HMUK RS11950
gene id: 485914:HMUK_RS11950
uniprot id: C7NYC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

485914:HMUK RS06205
gene id: 485914:HMUK_RS06205
uniprot id: C7P2V4
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS14645
gene id: 485914:HMUK_RS14645
uniprot id: C7P1N6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

485914:HMUK RS03680
gene id: 485914:HMUK_RS03680
uniprot id: C7NZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

485914:HMUK RS16015
gene id: 485914:HMUK_RS16015
uniprot id: C7P511
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS03600
gene id: 485914:HMUK_RS03600
uniprot id: C7NZX7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS08390
gene id: 485914:HMUK_RS08390
uniprot id: C7P446
names: Similarity
messages: Belongs to the malic enzymes family.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

485914:HMUK RS13300
gene id: 485914:HMUK_RS13300
uniprot id: C7P056
names: Similarity
messages: Belongs to the UPF0212 family.

485914:HMUK RS13245
gene id: 485914:HMUK_RS13245
uniprot id: C7NZR8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

485914:HMUK RS08430
gene id: 485914:HMUK_RS08430
uniprot id: C7P453
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS06710
gene id: 485914:HMUK_RS06710
uniprot id: C7P356
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

485914:HMUK RS11300
gene id: 485914:HMUK_RS11300
uniprot id: C7NXM2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

485914:HMUK RS05845
gene id: 485914:HMUK_RS05845
uniprot id: C7P2N1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

485914:HMUK RS02340
gene id: 485914:HMUK_RS02340
uniprot id: C7NYI0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

485914:HMUK RS07765
gene id: 485914:HMUK_RS07765
uniprot id: C7P3R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

485914:HMUK RS06330
gene id: 485914:HMUK_RS06330
uniprot id: C7P2X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

485914:HMUK RS12960
gene id: 485914:HMUK_RS12960
uniprot id: C7NZL3
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

485914:HMUK RS02425
gene id: 485914:HMUK_RS02425
uniprot id: C7NYJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS03735
gene id: 485914:HMUK_RS03735
uniprot id: C7P005
names: Similarity
messages: Belongs to the threonine synthase family.

485914:HMUK RS08680
gene id: 485914:HMUK_RS08680
uniprot id: C7P4A5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

485914:HMUK RS07825
gene id: 485914:HMUK_RS07825
uniprot id: C7P3T1
names: Subcellular Location Annotation
messages: Cytoplasm

485914:HMUK RS09555
gene id: 485914:HMUK_RS09555
uniprot id: C7NVX6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

485914:HMUK RS10500
gene id: 485914:HMUK_RS10500
uniprot id: C7NWT4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

485914:HMUK RS09285
gene id: 485914:HMUK_RS09285
uniprot id: C7P4M9
names: Similarity
messages: Belongs to the glycosyl hydrolase 68 family.

485914:HMUK RS02460
gene id: 485914:HMUK_RS02460
uniprot id: C7NYK2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

485914:HMUK RS13205
gene id: 485914:HMUK_RS13205
uniprot id: C7NZR0
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS02770
gene id: 485914:HMUK_RS02770
uniprot id: C7NZ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

485914:HMUK RS06700
gene id: 485914:HMUK_RS06700
uniprot id: C7P354
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS00940
gene id: 485914:HMUK_RS00940
uniprot id: C7NWX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS05250
gene id: 485914:HMUK_RS05250
uniprot id: C7P1Z8
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

485914:HMUK RS11595
gene id: 485914:HMUK_RS11595
uniprot id: C7NY52
names: Similarity
messages: Belongs to the SDO1/SBDS family.

485914:HMUK RS00490
gene id: 485914:HMUK_RS00490
uniprot id: C7NWA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS12625
gene id: 485914:HMUK_RS12625
uniprot id: C7NZE6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

485914:HMUK RS06190
gene id: 485914:HMUK_RS06190
uniprot id: C7P2V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

485914:HMUK RS06760
gene id: 485914:HMUK_RS06760
uniprot id: C7P366
names: Similarity
messages: Belongs to the cytochrome P450 family.

485914:HMUK RS14375
gene id: 485914:HMUK_RS14375
uniprot id: C7P155
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS07590
gene id: 485914:HMUK_RS07590
uniprot id: C7P3N4
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS14530
gene id: 485914:HMUK_RS14530
uniprot id: C7P1L2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

485914:HMUK RS09815
gene id: 485914:HMUK_RS09815
uniprot id: C7NW31
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS11460
gene id: 485914:HMUK_RS11460
uniprot id: C7NY26
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

485914:HMUK RS01530
gene id: 485914:HMUK_RS01530
uniprot id: C7NXM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

485914:HMUK RS14390
gene id: 485914:HMUK_RS14390
uniprot id: C7P158
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485914:HMUK RS13990
gene id: 485914:HMUK_RS13990
uniprot id: C7P0X7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

485914:HMUK RS06025
gene id: 485914:HMUK_RS06025
uniprot id: C7P2R8
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

485914:HMUK RS00290
gene id: 485914:HMUK_RS00290
uniprot id: C7NVU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS02415
gene id: 485914:HMUK_RS02415
uniprot id: C7NYJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

485914:HMUK RS08070
gene id: 485914:HMUK_RS08070
uniprot id: C7P3Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS12270
gene id: 485914:HMUK_RS12270
uniprot id: C7NYV9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

485914:HMUK RS09800
gene id: 485914:HMUK_RS09800
uniprot id: C7NW28
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

485914:HMUK RS00985
gene id: 485914:HMUK_RS00985
uniprot id: C7NWY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS04205
gene id: 485914:HMUK_RS04205
uniprot id: C7P0N3
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS12570
gene id: 485914:HMUK_RS12570
uniprot id: C7NZ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

485914:HMUK RS05495
gene id: 485914:HMUK_RS05495
uniprot id: C7P250
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

485914:HMUK RS12715
gene id: 485914:HMUK_RS12715
uniprot id: C7NZG6
names: Similarity
messages: Belongs to the HerA family.

485914:HMUK RS15625
gene id: 485914:HMUK_RS15625
uniprot id: C7P4T4
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

485914:HMUK RS03350
gene id: 485914:HMUK_RS03350
uniprot id: C7NZS4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

485914:HMUK RS08475
gene id: 485914:HMUK_RS08475
uniprot id: C7P463
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS10860
gene id: 485914:HMUK_RS10860
uniprot id: C7NXD1
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS08555
gene id: 485914:HMUK_RS08555
uniprot id: C7P479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

485914:HMUK RS06940
gene id: 485914:HMUK_RS06940
uniprot id: C7P3A1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS10945
gene id: 485914:HMUK_RS10945
uniprot id: C7NXE8
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS07120
gene id: 485914:HMUK_RS07120
uniprot id: C7P3D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

485914:HMUK RS03560
gene id: 485914:HMUK_RS03560
uniprot id: C7NZW9
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS11935
gene id: 485914:HMUK_RS11935
uniprot id: C7NYC0
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS07250
gene id: 485914:HMUK_RS07250
uniprot id: C7P3G2
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS04235
gene id: 485914:HMUK_RS04235
uniprot id: C7P0N9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

485914:HMUK RS09155
gene id: 485914:HMUK_RS09155
uniprot id: C7P4K3
names: Similarity
messages: Belongs to the DMRL synthase family.

485914:HMUK RS08790
gene id: 485914:HMUK_RS08790
uniprot id: C7P4C7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

485914:HMUK RS03355
gene id: 485914:HMUK_RS03355
uniprot id: C7NZS5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

485914:HMUK RS07690
gene id: 485914:HMUK_RS07690
uniprot id: C7P3Q3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

485914:HMUK RS05110
gene id: 485914:HMUK_RS05110
uniprot id: C7P1J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

485914:HMUK RS01370
gene id: 485914:HMUK_RS01370
uniprot id: C7NX71
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

485914:HMUK RS07615
gene id: 485914:HMUK_RS07615
uniprot id: C7P3N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS08815
gene id: 485914:HMUK_RS08815
uniprot id: C7P4D2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

485914:HMUK RS12135
gene id: 485914:HMUK_RS12135
uniprot id: C7NYT2
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS14305
gene id: 485914:HMUK_RS14305
uniprot id: C7P140
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS06150
gene id: 485914:HMUK_RS06150
uniprot id: C7P2U3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS10600
gene id: 485914:HMUK_RS10600
uniprot id: C7NWV4
names: Similarity
messages: Belongs to the Nth/MutY family.

485914:HMUK RS06125
gene id: 485914:HMUK_RS06125
uniprot id: C7P2T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

485914:HMUK RS10970
gene id: 485914:HMUK_RS10970
uniprot id: C7NXF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS08080
gene id: 485914:HMUK_RS08080
uniprot id: C7P3Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS06835
gene id: 485914:HMUK_RS06835
uniprot id: C7P382
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

485914:HMUK RS00880
gene id: 485914:HMUK_RS00880
uniprot id: C7NWJ1
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS11105
gene id: 485914:HMUK_RS11105
uniprot id: C7NXI2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

485914:HMUK RS08315
gene id: 485914:HMUK_RS08315
uniprot id: C7P431
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

485914:HMUK RS13375
gene id: 485914:HMUK_RS13375
uniprot id: C7P072
names: Similarity
messages: Belongs to the UPF0173 family.

485914:HMUK RS03480
gene id: 485914:HMUK_RS03480
uniprot id: C7NZV3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

485914:HMUK RS01870
gene id: 485914:HMUK_RS01870
uniprot id: C7NXV2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

485914:HMUK RS09400
gene id: 485914:HMUK_RS09400
uniprot id: C7P4Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

485914:HMUK RS02965
gene id: 485914:HMUK_RS02965
uniprot id: C7NZ73
names: Similarity
messages: Belongs to the SUI1 family.

485914:HMUK RS10470
gene id: 485914:HMUK_RS10470
uniprot id: C7NWS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

485914:HMUK RS14240
gene id: 485914:HMUK_RS14240
uniprot id: C7P127
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

485914:HMUK RS05160
gene id: 485914:HMUK_RS05160
uniprot id: C7P1Y0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS06080
gene id: 485914:HMUK_RS06080
uniprot id: C7P2S9
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

485914:HMUK RS00010
gene id: 485914:HMUK_RS00010
uniprot id: C7NVN8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS01910
gene id: 485914:HMUK_RS01910
uniprot id: C7NXW0
names: Similarity
messages: Belongs to the 2Fe2S plant-type ferredoxin family.

485914:HMUK RS09095
gene id: 485914:HMUK_RS09095
uniprot id: C7P4I8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

485914:HMUK RS01605
gene id: 485914:HMUK_RS01605
uniprot id: C7NXP4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

485914:HMUK RS03225
gene id: 485914:HMUK_RS03225
uniprot id: C7NZC2
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

485914:HMUK RS02785
gene id: 485914:HMUK_RS02785
uniprot id: C7NZ37
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS12985
gene id: 485914:HMUK_RS12985
uniprot id: C7NZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

485914:HMUK RS01585
gene id: 485914:HMUK_RS01585
uniprot id: C7NXP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

485914:HMUK RS01660
gene id: 485914:HMUK_RS01660
uniprot id: C7NXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

485914:HMUK RS07410
gene id: 485914:HMUK_RS07410
uniprot id: C7P3J6
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

485914:HMUK RS15275
gene id: 485914:HMUK_RS15275
uniprot id: C7P2E4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS09445
gene id: 485914:HMUK_RS09445
uniprot id: C7NVV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

485914:HMUK RS03550
gene id: 485914:HMUK_RS03550
uniprot id: C7NZW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

485914:HMUK RS08775
gene id: 485914:HMUK_RS08775
uniprot id: C7P4C4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

485914:HMUK RS01880
gene id: 485914:HMUK_RS01880
uniprot id: C7NXV4
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS14205
gene id: 485914:HMUK_RS14205
uniprot id: C7P120
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Tetramer of two components I and two components II.

485914:HMUK RS11500
gene id: 485914:HMUK_RS11500
uniprot id: C7NY34
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS14360
gene id: 485914:HMUK_RS14360
uniprot id: C7P152
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

485914:HMUK RS02370
gene id: 485914:HMUK_RS02370
uniprot id: C7NYI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

485914:HMUK RS07865
gene id: 485914:HMUK_RS07865
uniprot id: C7P3T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

485914:HMUK RS06695
gene id: 485914:HMUK_RS06695
uniprot id: C7P353
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS16290
gene id: 485914:HMUK_RS16290
uniprot id: C7P569
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS01800
gene id: 485914:HMUK_RS01800
uniprot id: C7NXT7
names: Similarity
messages: Belongs to the Dps family.

485914:HMUK RS12695
gene id: 485914:HMUK_RS12695
uniprot id: C7NZG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

485914:HMUK RS14225
gene id: 485914:HMUK_RS14225
uniprot id: C7P124
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

485914:HMUK RS13740
gene id: 485914:HMUK_RS13740
uniprot id: C7P0F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

485914:HMUK RS04820
gene id: 485914:HMUK_RS04820
uniprot id: C7P1D4
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS08580
gene id: 485914:HMUK_RS08580
uniprot id: C7P484
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

485914:HMUK RS06110
gene id: 485914:HMUK_RS06110
uniprot id: C7P2T5
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

485914:HMUK RS03785
gene id: 485914:HMUK_RS03785
uniprot id: C7P016
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

485914:HMUK RS02800
gene id: 485914:HMUK_RS02800
uniprot id: C7NZ40
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

485914:HMUK RS08820
gene id: 485914:HMUK_RS08820
uniprot id: C7P4D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

485914:HMUK RS10670
gene id: 485914:HMUK_RS10670
uniprot id: C7NWW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

485914:HMUK RS09150
gene id: 485914:HMUK_RS09150
uniprot id: C7P4K2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

485914:HMUK RS12210
gene id: 485914:HMUK_RS12210
uniprot id: C7NYU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS14620
gene id: 485914:HMUK_RS14620
uniprot id: C7P1N1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

485914:HMUK RS07385
gene id: 485914:HMUK_RS07385
uniprot id: C7P3J1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS00205
gene id: 485914:HMUK_RS00205
uniprot id: C7NVS7
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Belongs to the isochorismate synthase family.

485914:HMUK RS02565
gene id: 485914:HMUK_RS02565
uniprot id: C7NYM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

485914:HMUK RS13240
gene id: 485914:HMUK_RS13240
uniprot id: C7NZR7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

485914:HMUK RS14835
gene id: 485914:HMUK_RS14835
uniprot id: C7P1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

485914:HMUK RS06065
gene id: 485914:HMUK_RS06065
uniprot id: C7P2S6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS08050
gene id: 485914:HMUK_RS08050
uniprot id: C7P3X7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS00945
gene id: 485914:HMUK_RS00945
uniprot id: C7NWY0
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

485914:HMUK RS00855
gene id: 485914:HMUK_RS00855
uniprot id: C7NWI6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

485914:HMUK RS13530
gene id: 485914:HMUK_RS13530
uniprot id: C7P0A6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS14695
gene id: 485914:HMUK_RS14695
uniprot id: C7P1P6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS03430
gene id: 485914:HMUK_RS03430
uniprot id: C7NZU0
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

485914:HMUK RS06625
gene id: 485914:HMUK_RS06625
uniprot id: C7P338
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

485914:HMUK RS16180
gene id: 485914:HMUK_RS16180
uniprot id: C7P543
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

485914:HMUK RS15205
gene id: 485914:HMUK_RS15205
uniprot id: C7P2C9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

485914:HMUK RS14875
gene id: 485914:HMUK_RS14875
uniprot id: C7P1T4
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS04355
gene id: 485914:HMUK_RS04355
uniprot id: C7P0R3
names: Similarity
messages: Belongs to the MoaB/Mog family.

485914:HMUK RS06635
gene id: 485914:HMUK_RS06635
uniprot id: C7P340
names: Similarity
messages: Belongs to the PspA/IM30 family.

485914:HMUK RS15090
gene id: 485914:HMUK_RS15090
uniprot id: C7P2A4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

485914:HMUK RS13340
gene id: 485914:HMUK_RS13340
uniprot id: C7P065
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

485914:HMUK RS12900
gene id: 485914:HMUK_RS12900
uniprot id: C7NZK1
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

485914:HMUK RS10620
gene id: 485914:HMUK_RS10620
uniprot id: C7NWV8
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS06090
gene id: 485914:HMUK_RS06090
uniprot id: C7P2T1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

485914:HMUK RS16185
gene id: 485914:HMUK_RS16185
uniprot id: C7P544
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

485914:HMUK RS00040
gene id: 485914:HMUK_RS00040
uniprot id: C7NVP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

485914:HMUK RS04935
gene id: 485914:HMUK_RS04935
uniprot id: C7P1F5
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS07255
gene id: 485914:HMUK_RS07255
uniprot id: C7P3G3
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS03170
gene id: 485914:HMUK_RS03170
uniprot id: C7NZB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

485914:HMUK RS02335
gene id: 485914:HMUK_RS02335
uniprot id: C7NYH9
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS08980
gene id: 485914:HMUK_RS08980
uniprot id: C7P4G5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

485914:HMUK RS15610
gene id: 485914:HMUK_RS15610
uniprot id: C7P4T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS10580
gene id: 485914:HMUK_RS10580
uniprot id: C7NWV0
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS14705
gene id: 485914:HMUK_RS14705
uniprot id: C7P1P8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS05690
gene id: 485914:HMUK_RS05690
uniprot id: C7P290
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS00645
gene id: 485914:HMUK_RS00645
uniprot id: C7NWE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485914:HMUK RS14095
gene id: 485914:HMUK_RS14095
uniprot id: C7P0Z9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485914:HMUK RS13575
gene id: 485914:HMUK_RS13575
uniprot id: C7P0B5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS07200
gene id: 485914:HMUK_RS07200
uniprot id: C7P3F2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

485914:HMUK RS01405
gene id: 485914:HMUK_RS01405
uniprot id: C7NX78
names: Similarity
messages: Belongs to the UPF0146 family.

485914:HMUK RS08405
gene id: 485914:HMUK_RS08405
uniprot id: C7P449
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

485914:HMUK RS15395
gene id: 485914:HMUK_RS15395
uniprot id: C7P2G8
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS13155
gene id: 485914:HMUK_RS13155
uniprot id: C7NZQ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

485914:HMUK RS13135
gene id: 485914:HMUK_RS13135
uniprot id: C7NZP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS10530
gene id: 485914:HMUK_RS10530
uniprot id: C7NWU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

485914:HMUK RS03525
gene id: 485914:HMUK_RS03525
uniprot id: C7NZW2
names: Function
messages: Part of a potassium transport system.

485914:HMUK RS07850
gene id: 485914:HMUK_RS07850
uniprot id: C7P3T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

485914:HMUK RS13060
gene id: 485914:HMUK_RS13060
uniprot id: C7NZN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

485914:HMUK RS02410
gene id: 485914:HMUK_RS02410
uniprot id: C7NYJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

485914:HMUK RS05710
gene id: 485914:HMUK_RS05710
uniprot id: C7P294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

485914:HMUK RS01925
gene id: 485914:HMUK_RS01925
uniprot id: C7NXW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS05300
gene id: 485914:HMUK_RS05300
uniprot id: C7P209
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

485914:HMUK RS06170
gene id: 485914:HMUK_RS06170
uniprot id: C7P2U7
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS01045
gene id: 485914:HMUK_RS01045
uniprot id: C7NX01
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS03205
gene id: 485914:HMUK_RS03205
uniprot id: C7NZB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

485914:HMUK RS03695
gene id: 485914:HMUK_RS03695
uniprot id: C7NZZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS03675
gene id: 485914:HMUK_RS03675
uniprot id: C7NZZ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS06085
gene id: 485914:HMUK_RS06085
uniprot id: C7P2T0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

485914:HMUK RS09275
gene id: 485914:HMUK_RS09275
uniprot id: C7P4M7
names: Similarity
messages: Belongs to the HypE family.

485914:HMUK RS08445
gene id: 485914:HMUK_RS08445
uniprot id: C7P457
names: Similarity
messages: Belongs to the PspA/IM30 family.

485914:HMUK RS13775
gene id: 485914:HMUK_RS13775
uniprot id: C7P0F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

485914:HMUK RS07260
gene id: 485914:HMUK_RS07260
uniprot id: C7P3G4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

485914:HMUK RS13830
gene id: 485914:HMUK_RS13830
uniprot id: C7P0G9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS07935
gene id: 485914:HMUK_RS07935
uniprot id: C7P3V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS13690
gene id: 485914:HMUK_RS13690
uniprot id: C7P0E1
names: Similarity
messages: Belongs to the peptidase S49 family.

485914:HMUK RS05840
gene id: 485914:HMUK_RS05840
uniprot id: C7P2N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

485914:HMUK RS14050
gene id: 485914:HMUK_RS14050
uniprot id: C7P0Y9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

485914:HMUK RS10265
gene id: 485914:HMUK_RS10265
uniprot id: C7NWN7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS14550
gene id: 485914:HMUK_RS14550
uniprot id: C7P1L7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for chromosome condensation and partitioning.

485914:HMUK RS09220
gene id: 485914:HMUK_RS09220
uniprot id: C7P4L6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS05180
gene id: 485914:HMUK_RS05180
uniprot id: C7P1Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

485914:HMUK RS11665
gene id: 485914:HMUK_RS11665
uniprot id: C7NY66
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

485914:HMUK RS01855
gene id: 485914:HMUK_RS01855
uniprot id: C7NXU9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

485914:HMUK RS13945
gene id: 485914:HMUK_RS13945
uniprot id: C7P0W8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

485914:HMUK RS10520
gene id: 485914:HMUK_RS10520
uniprot id: C7NWT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

485914:HMUK RS10250
gene id: 485914:HMUK_RS10250
uniprot id: C7NWN4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

485914:HMUK RS10920
gene id: 485914:HMUK_RS10920
uniprot id: C7NXE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS02145
gene id: 485914:HMUK_RS02145
uniprot id: C7NYD8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

485914:HMUK RS00145
gene id: 485914:HMUK_RS00145
uniprot id: C7NVR5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

485914:HMUK RS05850
gene id: 485914:HMUK_RS05850
uniprot id: C7P2N2
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

485914:HMUK RS13800
gene id: 485914:HMUK_RS13800
uniprot id: C7P0G3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

485914:HMUK RS06225
gene id: 485914:HMUK_RS06225
uniprot id: C7P2V8
names: Similarity
messages: Belongs to the PdaD family.

485914:HMUK RS15355
gene id: 485914:HMUK_RS15355
uniprot id: C7P2G0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

485914:HMUK RS03700
gene id: 485914:HMUK_RS03700
uniprot id: C7NZZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS14885
gene id: 485914:HMUK_RS14885
uniprot id: C7P1T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS05165
gene id: 485914:HMUK_RS05165
uniprot id: C7P1Y1
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS03410
gene id: 485914:HMUK_RS03410
uniprot id: C7NZT6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

485914:HMUK RS01820
gene id: 485914:HMUK_RS01820
uniprot id: C7NXU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

485914:HMUK RS04160
gene id: 485914:HMUK_RS04160
uniprot id: C7P0M4
names: Similarity
messages: Belongs to the IMPACT family.

485914:HMUK RS11545
gene id: 485914:HMUK_RS11545
uniprot id: C7NY42
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

485914:HMUK RS14720
gene id: 485914:HMUK_RS14720
uniprot id: C7P1Q1
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

485914:HMUK RS14565
gene id: 485914:HMUK_RS14565
uniprot id: C7P1M0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

485914:HMUK RS09075
gene id: 485914:HMUK_RS09075
uniprot id: C7P4I4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

485914:HMUK RS06060
gene id: 485914:HMUK_RS06060
uniprot id: C7P2S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

485914:HMUK RS09160
gene id: 485914:HMUK_RS09160
uniprot id: C7P4K4
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS00845
gene id: 485914:HMUK_RS00845
uniprot id: C7NWI4
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

485914:HMUK RS05970
gene id: 485914:HMUK_RS05970
uniprot id: C7P2Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

485914:HMUK RS11465
gene id: 485914:HMUK_RS11465
uniprot id: C7NY27
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

485914:HMUK RS04765
gene id: 485914:HMUK_RS04765
uniprot id: C7P1C3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

485914:HMUK RS15185
gene id: 485914:HMUK_RS15185
uniprot id: C7P2C4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

485914:HMUK RS09940
gene id: 485914:HMUK_RS09940
uniprot id: C7NW52
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485914:HMUK RS02910
gene id: 485914:HMUK_RS02910
uniprot id: C7NZ62
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS03705
gene id: 485914:HMUK_RS03705
uniprot id: C7NZZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

485914:HMUK RS00500
gene id: 485914:HMUK_RS00500
uniprot id: C7NWB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS04960
gene id: 485914:HMUK_RS04960
uniprot id: C7P1F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

485914:HMUK RS09050
gene id: 485914:HMUK_RS09050
uniprot id: C7P4H9
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS06415
gene id: 485914:HMUK_RS06415
uniprot id: C7P2Z6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS12940
gene id: 485914:HMUK_RS12940
uniprot id: C7NZK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

485914:HMUK RS11355
gene id: 485914:HMUK_RS11355
uniprot id: C7NY07
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

485914:HMUK RS08785
gene id: 485914:HMUK_RS08785
uniprot id: C7P4C6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS16035
gene id: 485914:HMUK_RS16035
uniprot id: C7P515
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

485914:HMUK RS15615
gene id: 485914:HMUK_RS15615
uniprot id: C7P4T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS03195
gene id: 485914:HMUK_RS03195
uniprot id: C7NZB6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

485914:HMUK RS05805
gene id: 485914:HMUK_RS05805
uniprot id: C7P2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485914:HMUK RS10640
gene id: 485914:HMUK_RS10640
uniprot id: C7NWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

485914:HMUK RS04715
gene id: 485914:HMUK_RS04715
uniprot id: C7P1B4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

485914:HMUK RS04390
gene id: 485914:HMUK_RS04390
uniprot id: C7P0S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

485914:HMUK RS03460
gene id: 485914:HMUK_RS03460
uniprot id: C7NZU9
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

485914:HMUK RS15745
gene id: 485914:HMUK_RS15745
uniprot id: C7P4V7
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

485914:HMUK RS08575
gene id: 485914:HMUK_RS08575
uniprot id: C7P483
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485914:HMUK RS05880
gene id: 485914:HMUK_RS05880
uniprot id: C7P2N8
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

485914:HMUK RS09175
gene id: 485914:HMUK_RS09175
uniprot id: C7P4K7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

485914:HMUK RS09920
gene id: 485914:HMUK_RS09920
uniprot id: C7NW49
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

485914:HMUK RS09595
gene id: 485914:HMUK_RS09595
uniprot id: C7NVY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

485914:HMUK RS11120
gene id: 485914:HMUK_RS11120
uniprot id: C7NXI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS12495
gene id: 485914:HMUK_RS12495
uniprot id: C7NZ02
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

485914:HMUK RS06160
gene id: 485914:HMUK_RS06160
uniprot id: C7P2U5
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS06840
gene id: 485914:HMUK_RS06840
uniprot id: C7P383
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

485914:HMUK RS01140
gene id: 485914:HMUK_RS01140
uniprot id: C7NX20
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

485914:HMUK RS11065
gene id: 485914:HMUK_RS11065
uniprot id: C7NXH4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS14600
gene id: 485914:HMUK_RS14600
uniprot id: C7P1M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

485914:HMUK RS12245
gene id: 485914:HMUK_RS12245
uniprot id: C7NYV4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

485914:HMUK RS00755
gene id: 485914:HMUK_RS00755
uniprot id: C7NWG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

485914:HMUK RS05755
gene id: 485914:HMUK_RS05755
uniprot id: C7P2L0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

485914:HMUK RS12180
gene id: 485914:HMUK_RS12180
uniprot id: C7NYU1
names: Similarity
messages: Belongs to the PEPCase type 1 family.

485914:HMUK RS13595
gene id: 485914:HMUK_RS13595
uniprot id: C7P0B9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

485914:HMUK RS05705
gene id: 485914:HMUK_RS05705
uniprot id: C7P293
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

485914:HMUK RS11370
gene id: 485914:HMUK_RS11370
uniprot id: C7NY10
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

485914:HMUK RS14715
gene id: 485914:HMUK_RS14715
uniprot id: C7P1Q0
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

485914:HMUK RS12580
gene id: 485914:HMUK_RS12580
uniprot id: C7NZ16
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

485914:HMUK RS04015
gene id: 485914:HMUK_RS04015
uniprot id: C7P0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

485914:HMUK RS03630
gene id: 485914:HMUK_RS03630
uniprot id: C7NZY3
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS00885
gene id: 485914:HMUK_RS00885
uniprot id: C7NWJ2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

485914:HMUK RS03155
gene id: 485914:HMUK_RS03155
uniprot id: C7NZA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

485914:HMUK RS01110
gene id: 485914:HMUK_RS01110
uniprot id: C7NX14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

485914:HMUK RS06145
gene id: 485914:HMUK_RS06145
uniprot id: C7P2U2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS09350
gene id: 485914:HMUK_RS09350
uniprot id: C7P4P3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS04795
gene id: 485914:HMUK_RS04795
uniprot id: C7P1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

485914:HMUK RS01440
gene id: 485914:HMUK_RS01440
uniprot id: C7NX85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

485914:HMUK RS11055
gene id: 485914:HMUK_RS11055
uniprot id: C7NXH2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

485914:HMUK RS03425
gene id: 485914:HMUK_RS03425
uniprot id: C7NZT9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

485914:HMUK RS00230
gene id: 485914:HMUK_RS00230
uniprot id: C7NVT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS07555
gene id: 485914:HMUK_RS07555
uniprot id: C7P3M7
names: Similarity
messages: Belongs to the Ahb/Nir family.

485914:HMUK RS13580
gene id: 485914:HMUK_RS13580
uniprot id: C7P0B6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS09195
gene id: 485914:HMUK_RS09195
uniprot id: C7P4L1
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS13840
gene id: 485914:HMUK_RS13840
uniprot id: C7P0H1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS03900
gene id: 485914:HMUK_RS03900
uniprot id: C7P042
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

485914:HMUK RS01280
gene id: 485914:HMUK_RS01280
uniprot id: C7NX49
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

485914:HMUK RS06005
gene id: 485914:HMUK_RS06005
uniprot id: C7P2R3
names: Similarity
messages: Belongs to the UPF0201 family.

485914:HMUK RS12040
gene id: 485914:HMUK_RS12040
uniprot id: C7NYR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

485914:HMUK RS14295
gene id: 485914:HMUK_RS14295
uniprot id: C7P138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

485914:HMUK RS14015
gene id: 485914:HMUK_RS14015
uniprot id: C7P0Y2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS15080
gene id: 485914:HMUK_RS15080
uniprot id: C7P1X7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS12350
gene id: 485914:HMUK_RS12350
uniprot id: C7NYX4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

485914:HMUK RS07600
gene id: 485914:HMUK_RS07600
uniprot id: C7P3N6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS06650
gene id: 485914:HMUK_RS06650
uniprot id: C7P343
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

485914:HMUK RS10370
gene id: 485914:HMUK_RS10370
uniprot id: C7NWQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

485914:HMUK RS05645
gene id: 485914:HMUK_RS05645
uniprot id: C7P281
names: Function
messages: Part of a potassium transport system.

485914:HMUK RS06215
gene id: 485914:HMUK_RS06215
uniprot id: C7P2V6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

485914:HMUK RS03515
gene id: 485914:HMUK_RS03515
uniprot id: C7NZW0
names: Similarity
messages: Belongs to the thioesterase PaaI family.

485914:HMUK RS13410
gene id: 485914:HMUK_RS13410
uniprot id: C7P079
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

485914:HMUK RS06905
gene id: 485914:HMUK_RS06905
uniprot id: C7P396
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

485914:HMUK RS12215
gene id: 485914:HMUK_RS12215
uniprot id: C7NYU8
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS01400
gene id: 485914:HMUK_RS01400
uniprot id: C7NX77
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

485914:HMUK RS03300
gene id: 485914:HMUK_RS03300
uniprot id: C7NZD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

485914:HMUK RS08300
gene id: 485914:HMUK_RS08300
uniprot id: C7P428
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485914:HMUK RS00085
gene id: 485914:HMUK_RS00085
uniprot id: C7NVQ3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

485914:HMUK RS12855
gene id: 485914:HMUK_RS12855
uniprot id: C7NZJ2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS12220
gene id: 485914:HMUK_RS12220
uniprot id: C7NYU9
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS15435
gene id: 485914:HMUK_RS15435
uniprot id: C7P2H7
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

485914:HMUK RS01300
gene id: 485914:HMUK_RS01300
uniprot id: C7NX53
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

485914:HMUK RS16300
gene id: 485914:HMUK_RS16300
uniprot id: C7P572
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS13905
gene id: 485914:HMUK_RS13905
uniprot id: C7P0W1
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

485914:HMUK RS14575
gene id: 485914:HMUK_RS14575
uniprot id: C7P1M2
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

485914:HMUK RS02510
gene id: 485914:HMUK_RS02510
uniprot id: C7NYL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS15590
gene id: 485914:HMUK_RS15590
uniprot id: C7P2K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

485914:HMUK RS07610
gene id: 485914:HMUK_RS07610
uniprot id: C7P3N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS14520
gene id: 485914:HMUK_RS14520
uniprot id: C7P1L0
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

485914:HMUK RS06270
gene id: 485914:HMUK_RS06270
uniprot id: C7P2W7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS02345
gene id: 485914:HMUK_RS02345
uniprot id: C7NYI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

485914:HMUK RS06180
gene id: 485914:HMUK_RS06180
uniprot id: C7P2U9
names: Similarity
messages: Belongs to the PDCD5 family.

485914:HMUK RS14405
gene id: 485914:HMUK_RS14405
uniprot id: C7P162
names: Similarity
messages: Belongs to the glutaredoxin family.

485914:HMUK RS07105
gene id: 485914:HMUK_RS07105
uniprot id: C7P3D5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

485914:HMUK RS01525
gene id: 485914:HMUK_RS01525
uniprot id: C7NXM8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS10770
gene id: 485914:HMUK_RS10770
uniprot id: C7NXB4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.

485914:HMUK RS11585
gene id: 485914:HMUK_RS11585
uniprot id: C7NY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

485914:HMUK RS03590
gene id: 485914:HMUK_RS03590
uniprot id: C7NZX5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

485914:HMUK RS00565
gene id: 485914:HMUK_RS00565
uniprot id: C7NWC4
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS07680
gene id: 485914:HMUK_RS07680
uniprot id: C7P3Q1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

485914:HMUK RS07220
gene id: 485914:HMUK_RS07220
uniprot id: C7P3F6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS02350
gene id: 485914:HMUK_RS02350
uniprot id: C7NYI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS15490
gene id: 485914:HMUK_RS15490
uniprot id: C7P2I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

485914:HMUK RS11625
gene id: 485914:HMUK_RS11625
uniprot id: C7NY58
names: Similarity
messages: Belongs to the UPF0212 family.

485914:HMUK RS09180
gene id: 485914:HMUK_RS09180
uniprot id: C7P4K8
names: Similarity
messages: Belongs to the complex I subunit 3 family.

485914:HMUK RS07010
gene id: 485914:HMUK_RS07010
uniprot id: C7P3B4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

485914:HMUK RS02465
gene id: 485914:HMUK_RS02465
uniprot id: C7NYK3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

485914:HMUK RS06735
gene id: 485914:HMUK_RS06735
uniprot id: C7P361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

485914:HMUK RS07970
gene id: 485914:HMUK_RS07970
uniprot id: C7P3W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

485914:HMUK RS04200
gene id: 485914:HMUK_RS04200
uniprot id: C7P0N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

485914:HMUK RS01420
gene id: 485914:HMUK_RS01420
uniprot id: C7NX81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS15555
gene id: 485914:HMUK_RS15555
uniprot id: C7P2K1
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS01860
gene id: 485914:HMUK_RS01860
uniprot id: C7NXV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS14380
gene id: 485914:HMUK_RS14380
uniprot id: C7P156
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

485914:HMUK RS13290
gene id: 485914:HMUK_RS13290
uniprot id: C7P053
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

485914:HMUK RS02290
gene id: 485914:HMUK_RS02290
uniprot id: C7NYH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

485914:HMUK RS13260
gene id: 485914:HMUK_RS13260
uniprot id: C7P047
names: Similarity
messages: Belongs to the arginase family.

485914:HMUK RS14045
gene id: 485914:HMUK_RS14045
uniprot id: C7P0Y8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

485914:HMUK RS05430
gene id: 485914:HMUK_RS05430
uniprot id: C7P237
names: Similarity
messages: Belongs to the phosphohexose mutase family.

485914:HMUK RS13465
gene id: 485914:HMUK_RS13465
uniprot id: C7P091
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

485914:HMUK RS06175
gene id: 485914:HMUK_RS06175
uniprot id: C7P2U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS00240
gene id: 485914:HMUK_RS00240
uniprot id: C7NVT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS05360
gene id: 485914:HMUK_RS05360
uniprot id: C7P221
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

485914:HMUK RS14475
gene id: 485914:HMUK_RS14475
uniprot id: C7P1K1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

485914:HMUK RS07670
gene id: 485914:HMUK_RS07670
uniprot id: C7P3P9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

485914:HMUK RS04500
gene id: 485914:HMUK_RS04500
uniprot id: C7P0U3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS08725
gene id: 485914:HMUK_RS08725
uniprot id: C7P4B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS03830
gene id: 485914:HMUK_RS03830
uniprot id: C7P026
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

485914:HMUK RS05530
gene id: 485914:HMUK_RS05530
uniprot id: C7P256
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

485914:HMUK RS02380
gene id: 485914:HMUK_RS02380
uniprot id: C7NYI8
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

485914:HMUK RS14260
gene id: 485914:HMUK_RS14260
uniprot id: C7P131
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS12535
gene id: 485914:HMUK_RS12535
uniprot id: C7NZ08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS02515
gene id: 485914:HMUK_RS02515
uniprot id: C7NYL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS11730
gene id: 485914:HMUK_RS11730
uniprot id: C7NY80
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

485914:HMUK RS05860
gene id: 485914:HMUK_RS05860
uniprot id: C7P2N4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

485914:HMUK RS04090
gene id: 485914:HMUK_RS04090
uniprot id: C7P0K9
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

485914:HMUK RS10665
gene id: 485914:HMUK_RS10665
uniprot id: C7NWW8
names: Subcellular Location Annotation
messages: Cell membrane

485914:HMUK RS10540
gene id: 485914:HMUK_RS10540
uniprot id: C7NWU2
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

485914:HMUK RS08685
gene id: 485914:HMUK_RS08685
uniprot id: C7P4A6
names: Caution
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS01730
gene id: 485914:HMUK_RS01730
uniprot id: C7NXS0
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS09045
gene id: 485914:HMUK_RS09045
uniprot id: C7P4H8
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS12065
gene id: 485914:HMUK_RS12065
uniprot id: C7NYR9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS08450
gene id: 485914:HMUK_RS08450
uniprot id: C7P458
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

485914:HMUK RS06770
gene id: 485914:HMUK_RS06770
uniprot id: C7P368
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS11825
gene id: 485914:HMUK_RS11825
uniprot id: C7NY98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

485914:HMUK RS15295
gene id: 485914:HMUK_RS15295
uniprot id: C7P2E8
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

485914:HMUK RS06300
gene id: 485914:HMUK_RS06300
uniprot id: C7P2X3
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

485914:HMUK RS04360
gene id: 485914:HMUK_RS04360
uniprot id: C7P0R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

485914:HMUK RS12790
gene id: 485914:HMUK_RS12790
uniprot id: C7NZH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485914:HMUK RS13445
gene id: 485914:HMUK_RS13445
uniprot id: C7P087
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

485914:HMUK RS05235
gene id: 485914:HMUK_RS05235
uniprot id: C7P1Z5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

485914:HMUK RS15655
gene id: 485914:HMUK_RS15655
uniprot id: C7P4T8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

485914:HMUK RS09225
gene id: 485914:HMUK_RS09225
uniprot id: C7P4L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

485914:HMUK RS12150
gene id: 485914:HMUK_RS12150
uniprot id: C7NYT5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

485914:HMUK RS03670
gene id: 485914:HMUK_RS03670
uniprot id: C7NZZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

485914:HMUK RS15580
gene id: 485914:HMUK_RS15580
uniprot id: C7P2K7
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

485914:HMUK RS05615
gene id: 485914:HMUK_RS05615
uniprot id: C7P275
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

485914:HMUK RS11925
gene id: 485914:HMUK_RS11925
uniprot id: C7NYB8
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

485914:HMUK RS16370
gene id: 485914:HMUK_RS16370
uniprot id: C7P4R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS08695
gene id: 485914:HMUK_RS08695
uniprot id: C7P4A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

485914:HMUK RS10965
gene id: 485914:HMUK_RS10965
uniprot id: C7NXF2
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS05185
gene id: 485914:HMUK_RS05185
uniprot id: C7P1Y5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS06485
gene id: 485914:HMUK_RS06485
uniprot id: C7P310
names: Subcellular Location Annotation
messages: Cell membrane

485914:HMUK RS03715
gene id: 485914:HMUK_RS03715
uniprot id: C7P000
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

485914:HMUK RS13285
gene id: 485914:HMUK_RS13285
uniprot id: C7P052
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

485914:HMUK RS10525
gene id: 485914:HMUK_RS10525
uniprot id: C7NWT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

485914:HMUK RS08915
gene id: 485914:HMUK_RS08915
uniprot id: C7P4F2
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

485914:HMUK RS14745
gene id: 485914:HMUK_RS14745
uniprot id: C7P1Q6
names: Similarity
messages: Belongs to the UPF0175 family.

485914:HMUK RS12650
gene id: 485914:HMUK_RS12650
uniprot id: C7NZF2
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

485914:HMUK RS08830
gene id: 485914:HMUK_RS08830
uniprot id: C7P4D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS09070
gene id: 485914:HMUK_RS09070
uniprot id: C7P4I3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

485914:HMUK RS09795
gene id: 485914:HMUK_RS09795
uniprot id: C7NW27
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

485914:HMUK RS14220
gene id: 485914:HMUK_RS14220
uniprot id: C7P123
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS12540
gene id: 485914:HMUK_RS12540
uniprot id: C7NZ09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

485914:HMUK RS14450
gene id: 485914:HMUK_RS14450
uniprot id: C7P171
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmE subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS04050
gene id: 485914:HMUK_RS04050
uniprot id: C7P0K1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

485914:HMUK RS03070
gene id: 485914:HMUK_RS03070
uniprot id: C7NZ95
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS09290
gene id: 485914:HMUK_RS09290
uniprot id: C7P4N0
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

485914:HMUK RS16335
gene id: 485914:HMUK_RS16335
uniprot id: C7P579
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

485914:HMUK RS00495
gene id: 485914:HMUK_RS00495
uniprot id: C7NWB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS06000
gene id: 485914:HMUK_RS06000
uniprot id: C7P2R2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

485914:HMUK RS02285
gene id: 485914:HMUK_RS02285
uniprot id: C7NYG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS06800
gene id: 485914:HMUK_RS06800
uniprot id: C7P375
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

485914:HMUK RS01165
gene id: 485914:HMUK_RS01165
uniprot id: C7NX25
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

485914:HMUK RS08335
gene id: 485914:HMUK_RS08335
uniprot id: C7P435
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

485914:HMUK RS04310
gene id: 485914:HMUK_RS04310
uniprot id: C7P0Q4
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

485914:HMUK RS14735
gene id: 485914:HMUK_RS14735
uniprot id: C7P1Q4
names: Similarity
messages: Belongs to the TrpC family.

485914:HMUK RS06745
gene id: 485914:HMUK_RS06745
uniprot id: C7P363
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

485914:HMUK RS06750
gene id: 485914:HMUK_RS06750
uniprot id: C7P364
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

485914:HMUK RS08870
gene id: 485914:HMUK_RS08870
uniprot id: C7P4E3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

485914:HMUK RS01115
gene id: 485914:HMUK_RS01115
uniprot id: C7NX15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

485914:HMUK RS03505
gene id: 485914:HMUK_RS03505
uniprot id: C7NZV8
names: Similarity
messages: Belongs to the AAA ATPase family.

485914:HMUK RS08720
gene id: 485914:HMUK_RS08720
uniprot id: C7P4B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS00805
gene id: 485914:HMUK_RS00805
uniprot id: C7NWH6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS08625
gene id: 485914:HMUK_RS08625
uniprot id: C7P493
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

485914:HMUK RS13700
gene id: 485914:HMUK_RS13700
uniprot id: C7P0E3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

485914:HMUK RS05610
gene id: 485914:HMUK_RS05610
uniprot id: C7P273
names: Similarity
messages: Belongs to the HAM1 NTPase family.

485914:HMUK RS15360
gene id: 485914:HMUK_RS15360
uniprot id: C7P2G1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

485914:HMUK RS10335
gene id: 485914:HMUK_RS10335
uniprot id: C7NWQ0
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS12005
gene id: 485914:HMUK_RS12005
uniprot id: C7NYQ6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS08850
gene id: 485914:HMUK_RS08850
uniprot id: C7P4D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

485914:HMUK RS11320
gene id: 485914:HMUK_RS11320
uniprot id: C7NY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

485914:HMUK RS08470
gene id: 485914:HMUK_RS08470
uniprot id: C7P462
names: Similarity
messages: Belongs to the TrpF family.

485914:HMUK RS03920
gene id: 485914:HMUK_RS03920
uniprot id: C7P0H3
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS06100
gene id: 485914:HMUK_RS06100
uniprot id: C7P2T3
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS00355
gene id: 485914:HMUK_RS00355
uniprot id: C7NW84
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

485914:HMUK RS03645
gene id: 485914:HMUK_RS03645
uniprot id: C7NZY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

485914:HMUK RS07785
gene id: 485914:HMUK_RS07785
uniprot id: C7P3S3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

485914:HMUK RS12390
gene id: 485914:HMUK_RS12390
uniprot id: C7NYY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

485914:HMUK RS03510
gene id: 485914:HMUK_RS03510
uniprot id: C7NZV9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

485914:HMUK RS10515
gene id: 485914:HMUK_RS10515
uniprot id: C7NWT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

485914:HMUK RS05305
gene id: 485914:HMUK_RS05305
uniprot id: C7P210
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

485914:HMUK RS08295
gene id: 485914:HMUK_RS08295
uniprot id: C7P427
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS10205
gene id: 485914:HMUK_RS10205
uniprot id: C7NWM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Cytoplasm

485914:HMUK RS15385
gene id: 485914:HMUK_RS15385
uniprot id: C7P2G6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS07270
gene id: 485914:HMUK_RS07270
uniprot id: C7P3G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

485914:HMUK RS14105
gene id: 485914:HMUK_RS14105
uniprot id: C7P101
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

485914:HMUK RS04285
gene id: 485914:HMUK_RS04285
uniprot id: C7P0Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

485914:HMUK RS05255
gene id: 485914:HMUK_RS05255
uniprot id: C7P1Z9
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS01235
gene id: 485914:HMUK_RS01235
uniprot id: C7NX39
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

485914:HMUK RS05270
gene id: 485914:HMUK_RS05270
uniprot id: C7P202
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

485914:HMUK RS11235
gene id: 485914:HMUK_RS11235
uniprot id: C7NXK8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

485914:HMUK RS05640
gene id: 485914:HMUK_RS05640
uniprot id: C7P280
names: Similarity
messages: Belongs to the UPF0215 family.

485914:HMUK RS00830
gene id: 485914:HMUK_RS00830
uniprot id: C7NWI1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

485914:HMUK RS07455
gene id: 485914:HMUK_RS07455
uniprot id: C7P3K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

485914:HMUK RS11115
gene id: 485914:HMUK_RS11115
uniprot id: C7NXI4
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

485914:HMUK RS07975
gene id: 485914:HMUK_RS07975
uniprot id: C7P3W2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS09995
gene id: 485914:HMUK_RS09995
uniprot id: C7NW63
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

485914:HMUK RS08560
gene id: 485914:HMUK_RS08560
uniprot id: C7P480
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

485914:HMUK RS08835
gene id: 485914:HMUK_RS08835
uniprot id: C7P4D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

485914:HMUK RS08975
gene id: 485914:HMUK_RS08975
uniprot id: C7P4G4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

485914:HMUK RS12685
gene id: 485914:HMUK_RS12685
uniprot id: C7NZG0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

485914:HMUK RS09550
gene id: 485914:HMUK_RS09550
uniprot id: C7NVX5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

485914:HMUK RS13950
gene id: 485914:HMUK_RS13950
uniprot id: C7P0W9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

485914:HMUK RS16095
gene id: 485914:HMUK_RS16095
uniprot id: C7P526
names: Similarity
messages: Belongs to the group II decarboxylase family.

485914:HMUK RS01355
gene id: 485914:HMUK_RS01355
uniprot id: C7NX68
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS03390
gene id: 485914:HMUK_RS03390
uniprot id: C7NZT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

485914:HMUK RS06165
gene id: 485914:HMUK_RS06165
uniprot id: C7P2U6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

485914:HMUK RS12955
gene id: 485914:HMUK_RS12955
uniprot id: C7NZL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

485914:HMUK RS15415
gene id: 485914:HMUK_RS15415
uniprot id: C7P2H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

485914:HMUK RS12950
gene id: 485914:HMUK_RS12950
uniprot id: C7NZL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

485914:HMUK RS03890
gene id: 485914:HMUK_RS03890
uniprot id: C7P040
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

485914:HMUK RS06105
gene id: 485914:HMUK_RS06105
uniprot id: C7P2T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane

485914:HMUK RS06070
gene id: 485914:HMUK_RS06070
uniprot id: C7P2S7
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

485914:HMUK RS09185
gene id: 485914:HMUK_RS09185
uniprot id: C7P4K9
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

485914:HMUK RS00480
gene id: 485914:HMUK_RS00480
uniprot id: C7NWA7
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS06285
gene id: 485914:HMUK_RS06285
uniprot id: C7P2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

485914:HMUK RS07965
gene id: 485914:HMUK_RS07965
uniprot id: C7P3W0
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS13955
gene id: 485914:HMUK_RS13955
uniprot id: C7P0X0
names: Similarity
messages: Belongs to the eIF-2-alpha family.

485914:HMUK RS13210
gene id: 485914:HMUK_RS13210
uniprot id: C7NZR1
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

485914:HMUK RS05835
gene id: 485914:HMUK_RS05835
uniprot id: C7P2M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

485914:HMUK RS15060
gene id: 485914:HMUK_RS15060
uniprot id: C7P1X3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485914:HMUK RS03110
gene id: 485914:HMUK_RS03110
uniprot id: C7NZA4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

485914:HMUK RS05685
gene id: 485914:HMUK_RS05685
uniprot id: C7P289
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS11700
gene id: 485914:HMUK_RS11700
uniprot id: C7NY74
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS02485
gene id: 485914:HMUK_RS02485
uniprot id: C7NYK7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485914:HMUK RS06730
gene id: 485914:HMUK_RS06730
uniprot id: C7P360
names: Similarity
messages: Belongs to the thymidylate kinase family.

485914:HMUK RS09190
gene id: 485914:HMUK_RS09190
uniprot id: C7P4L0
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

485914:HMUK RS09640
gene id: 485914:HMUK_RS09640
uniprot id: C7NVZ2
names: Subcellular Location Annotation
messages: Cytoplasm

485914:HMUK RS05150
gene id: 485914:HMUK_RS05150
uniprot id: C7P1X8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

485914:HMUK RS03160
gene id: 485914:HMUK_RS03160
uniprot id: C7NZA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

485914:HMUK RS14245
gene id: 485914:HMUK_RS14245
uniprot id: C7P128
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

485914:HMUK RS00505
gene id: 485914:HMUK_RS00505
uniprot id: C7NWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS05820
gene id: 485914:HMUK_RS05820
uniprot id: C7P2M6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

485914:HMUK RS13635
gene id: 485914:HMUK_RS13635
uniprot id: C7P0C8
names: Subcellular Location Annotation
messages: Cell membrane

485914:HMUK RS13235
gene id: 485914:HMUK_RS13235
uniprot id: C7NZR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

485914:HMUK RS05975
gene id: 485914:HMUK_RS05975
uniprot id: C7P2Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

485914:HMUK RS11980
gene id: 485914:HMUK_RS11980
uniprot id: C7NYQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

485914:HMUK RS12420
gene id: 485914:HMUK_RS12420
uniprot id: C7NYY7
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS07545
gene id: 485914:HMUK_RS07545
uniprot id: C7P3M5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

485914:HMUK RS10365
gene id: 485914:HMUK_RS10365
uniprot id: C7NWQ6
names: Similarity
messages: Belongs to the BtpA family.

485914:HMUK RS13915
gene id: 485914:HMUK_RS13915
uniprot id: C7P0W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

485914:HMUK RS05925
gene id: 485914:HMUK_RS05925
uniprot id: C7P2P7
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

485914:HMUK RS11885
gene id: 485914:HMUK_RS11885
uniprot id: C7NYB0
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS04165
gene id: 485914:HMUK_RS04165
uniprot id: C7P0M5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

485914:HMUK RS14670
gene id: 485914:HMUK_RS14670
uniprot id: C7P1P1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

485914:HMUK RS12430
gene id: 485914:HMUK_RS12430
uniprot id: C7NYY9
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

485914:HMUK RS09415
gene id: 485914:HMUK_RS09415
uniprot id: C7P4Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

485914:HMUK RS14700
gene id: 485914:HMUK_RS14700
uniprot id: C7P1P7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

485914:HMUK RS00105
gene id: 485914:HMUK_RS00105
uniprot id: C7NVQ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS15560
gene id: 485914:HMUK_RS15560
uniprot id: C7P2K2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS13520
gene id: 485914:HMUK_RS13520
uniprot id: C7P0A4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

485914:HMUK RS11965
gene id: 485914:HMUK_RS11965
uniprot id: C7NYP8
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS10975
gene id: 485914:HMUK_RS10975
uniprot id: C7NXF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS00965
gene id: 485914:HMUK_RS00965
uniprot id: C7NWY4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS14215
gene id: 485914:HMUK_RS14215
uniprot id: C7P122
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS12680
gene id: 485914:HMUK_RS12680
uniprot id: C7NZF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

485914:HMUK RS15495
gene id: 485914:HMUK_RS15495
uniprot id: C7P2I9
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

485914:HMUK RS11655
gene id: 485914:HMUK_RS11655
uniprot id: C7NY64
names: Subcellular Location Annotation
messages: Cytoplasm

485914:HMUK RS10385
gene id: 485914:HMUK_RS10385
uniprot id: C7NWR0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485914:HMUK RS09215
gene id: 485914:HMUK_RS09215
uniprot id: C7P4L5
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS11570
gene id: 485914:HMUK_RS11570
uniprot id: C7NY47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

485914:HMUK RS10660
gene id: 485914:HMUK_RS10660
uniprot id: C7NWW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

485914:HMUK RS05015
gene id: 485914:HMUK_RS05015
uniprot id: C7P1H0
names: Similarity
messages: Belongs to the UPF0047 family.

485914:HMUK RS17980
gene id: 485914:HMUK_RS17980
uniprot id: C7P570
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

485914:HMUK RS13255
gene id: 485914:HMUK_RS13255
uniprot id: C7NZS0
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

485914:HMUK RS13505
gene id: 485914:HMUK_RS13505
uniprot id: C7P0A1
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS06325
gene id: 485914:HMUK_RS06325
uniprot id: C7P2X8
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

485914:HMUK RS04275
gene id: 485914:HMUK_RS04275
uniprot id: C7P0P8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

485914:HMUK RS11030
gene id: 485914:HMUK_RS11030
uniprot id: C7NXG7
names: Similarity
messages: Belongs to the Dps family.

485914:HMUK RS16110
gene id: 485914:HMUK_RS16110
uniprot id: C7P529
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

485914:HMUK RS00930
gene id: 485914:HMUK_RS00930
uniprot id: C7NWX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS12145
gene id: 485914:HMUK_RS12145
uniprot id: C7NYT4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS01105
gene id: 485914:HMUK_RS01105
uniprot id: C7NX13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

485914:HMUK RS09735
gene id: 485914:HMUK_RS09735
uniprot id: C7NW13
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

485914:HMUK RS07890
gene id: 485914:HMUK_RS07890
uniprot id: C7P3U4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

485914:HMUK RS12560
gene id: 485914:HMUK_RS12560
uniprot id: C7NZ12
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

485914:HMUK RS01670
gene id: 485914:HMUK_RS01670
uniprot id: C7NXQ7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

485914:HMUK RS14370
gene id: 485914:HMUK_RS14370
uniprot id: C7P154
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

485914:HMUK RS09040
gene id: 485914:HMUK_RS09040
uniprot id: C7P4H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

485914:HMUK RS01175
gene id: 485914:HMUK_RS01175
uniprot id: C7NX27
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

485914:HMUK RS14110
gene id: 485914:HMUK_RS14110
uniprot id: C7P102
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS13425
gene id: 485914:HMUK_RS13425
uniprot id: C7P083
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

485914:HMUK RS10020
gene id: 485914:HMUK_RS10020
uniprot id: C7NW66
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485914:HMUK RS13295
gene id: 485914:HMUK_RS13295
uniprot id: C7P054
names: Similarity
messages: Belongs to the phosphohexose mutase family.

485914:HMUK RS11605
gene id: 485914:HMUK_RS11605
uniprot id: C7NY54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

485914:HMUK RS11210
gene id: 485914:HMUK_RS11210
uniprot id: C7NXK3
names: Similarity
messages: Belongs to the glutaredoxin family.

485914:HMUK RS11895
gene id: 485914:HMUK_RS11895
uniprot id: C7NYB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

485914:HMUK RS09345
gene id: 485914:HMUK_RS09345
uniprot id: C7P4P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the halobacterial S-layer protein family.
messages: Cell membrane
messages: Membrane
messages: S-layer

485914:HMUK RS07775
gene id: 485914:HMUK_RS07775
uniprot id: C7P3S1
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

485914:HMUK RS16355
gene id: 485914:HMUK_RS16355
uniprot id: C7P583
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS13750
gene id: 485914:HMUK_RS13750
uniprot id: C7P0F3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

485914:HMUK RS08100
gene id: 485914:HMUK_RS08100
uniprot id: C7P3Y7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

485914:HMUK RS03610
gene id: 485914:HMUK_RS03610
uniprot id: C7NZX9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

485914:HMUK RS01840
gene id: 485914:HMUK_RS01840
uniprot id: C7NXU6
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

485914:HMUK RS14730
gene id: 485914:HMUK_RS14730
uniprot id: C7P1Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

485914:HMUK RS15670
gene id: 485914:HMUK_RS15670
uniprot id: C7P4U1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

485914:HMUK RS10830
gene id: 485914:HMUK_RS10830
uniprot id: C7NXC5
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

485914:HMUK RS08810
gene id: 485914:HMUK_RS08810
uniprot id: C7P4D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

485914:HMUK RS15460
gene id: 485914:HMUK_RS15460
uniprot id: C7P2I2
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS16375
gene id: 485914:HMUK_RS16375
uniprot id: C7P4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS09145
gene id: 485914:HMUK_RS09145
uniprot id: C7P4K0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

485914:HMUK RS13745
gene id: 485914:HMUK_RS13745
uniprot id: C7P0F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

485914:HMUK RS11195
gene id: 485914:HMUK_RS11195
uniprot id: C7NXK0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

485914:HMUK RS15795
gene id: 485914:HMUK_RS15795
uniprot id: C7P4W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

485914:HMUK RS04485
gene id: 485914:HMUK_RS04485
uniprot id: C7P0U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS14195
gene id: 485914:HMUK_RS14195
uniprot id: C7P118
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

485914:HMUK RS03115
gene id: 485914:HMUK_RS03115
uniprot id: C7NZA5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

485914:HMUK RS09860
gene id: 485914:HMUK_RS09860
uniprot id: C7NW37
names: Similarity
messages: Belongs to the threonine aldolase family.

485914:HMUK RS01705
gene id: 485914:HMUK_RS01705
uniprot id: C7NXR5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

485914:HMUK RS07905
gene id: 485914:HMUK_RS07905
uniprot id: C7P3U7
names: Similarity
messages: Belongs to the peptidase S9C family.

485914:HMUK RS15240
gene id: 485914:HMUK_RS15240
uniprot id: C7P2D6
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

485914:HMUK RS00090
gene id: 485914:HMUK_RS00090
uniprot id: C7NVQ4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

485914:HMUK RS03910
gene id: 485914:HMUK_RS03910
uniprot id: C7P044
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

485914:HMUK RS09270
gene id: 485914:HMUK_RS09270
uniprot id: C7P4M6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS08665
gene id: 485914:HMUK_RS08665
uniprot id: C7P4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

485914:HMUK RS14760
gene id: 485914:HMUK_RS14760
uniprot id: C7P1Q9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS02365
gene id: 485914:HMUK_RS02365
uniprot id: C7NYI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

485914:HMUK RS10090
gene id: 485914:HMUK_RS10090
uniprot id: C7NWK1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

485914:HMUK RS08860
gene id: 485914:HMUK_RS08860
uniprot id: C7P4E1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

485914:HMUK RS12280
gene id: 485914:HMUK_RS12280
uniprot id: C7NYW1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

485914:HMUK RS07655
gene id: 485914:HMUK_RS07655
uniprot id: C7P3P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

485914:HMUK RS06075
gene id: 485914:HMUK_RS06075
uniprot id: C7P2S8
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

485914:HMUK RS12030
gene id: 485914:HMUK_RS12030
uniprot id: C7NYR1
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

485914:HMUK RS11455
gene id: 485914:HMUK_RS11455
uniprot id: C7NY25
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

485914:HMUK RS05585
gene id: 485914:HMUK_RS05585
uniprot id: C7P268
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

485914:HMUK RS08520
gene id: 485914:HMUK_RS08520
uniprot id: C7P472
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

485914:HMUK RS09100
gene id: 485914:HMUK_RS09100
uniprot id: C7P4I9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS07470
gene id: 485914:HMUK_RS07470
uniprot id: C7P3K8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

485914:HMUK RS13525
gene id: 485914:HMUK_RS13525
uniprot id: C7P0A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

485914:HMUK RS10900
gene id: 485914:HMUK_RS10900
uniprot id: C7NXD9
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

485914:HMUK RS08595
gene id: 485914:HMUK_RS08595
uniprot id: C7P487
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

485914:HMUK RS13160
gene id: 485914:HMUK_RS13160
uniprot id: C7NZQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

485914:HMUK RS03535
gene id: 485914:HMUK_RS03535
uniprot id: C7NZW4
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS04060
gene id: 485914:HMUK_RS04060
uniprot id: C7P0K3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

485914:HMUK RS00995
gene id: 485914:HMUK_RS00995
uniprot id: C7NWZ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS08075
gene id: 485914:HMUK_RS08075
uniprot id: C7P3Y2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS09030
gene id: 485914:HMUK_RS09030
uniprot id: C7P4H5
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

485914:HMUK RS12610
gene id: 485914:HMUK_RS12610
uniprot id: C7NZE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Homodimer.

485914:HMUK RS04830
gene id: 485914:HMUK_RS04830
uniprot id: C7P1D6
names: Subunit
messages: Homotrimer.

485914:HMUK RS12990
gene id: 485914:HMUK_RS12990
uniprot id: C7NZL9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS05275
gene id: 485914:HMUK_RS05275
uniprot id: C7P203
names: Similarity
messages: Belongs to the HMBS family.

485914:HMUK RS10155
gene id: 485914:HMUK_RS10155
uniprot id: C7NWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Nucleus

485914:HMUK RS09560
gene id: 485914:HMUK_RS09560
uniprot id: C7NVX7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

485914:HMUK RS12845
gene id: 485914:HMUK_RS12845
uniprot id: C7NZJ0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

485914:HMUK RS02430
gene id: 485914:HMUK_RS02430
uniprot id: C7NYJ6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

485914:HMUK RS02355
gene id: 485914:HMUK_RS02355
uniprot id: C7NYI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

485914:HMUK RS09165
gene id: 485914:HMUK_RS09165
uniprot id: C7P4K5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS15075
gene id: 485914:HMUK_RS15075
uniprot id: C7P1X6
names: Subcellular Location Annotation
messages: Cytoplasm

485914:HMUK RS01650
gene id: 485914:HMUK_RS01650
uniprot id: C7NXQ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS14590
gene id: 485914:HMUK_RS14590
uniprot id: C7P1M5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

485914:HMUK RS05115
gene id: 485914:HMUK_RS05115
uniprot id: C7P1J2
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS03880
gene id: 485914:HMUK_RS03880
uniprot id: C7P038
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

485914:HMUK RS13455
gene id: 485914:HMUK_RS13455
uniprot id: C7P089
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

485914:HMUK RS07125
gene id: 485914:HMUK_RS07125
uniprot id: C7P3D9
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

485914:HMUK RS08845
gene id: 485914:HMUK_RS08845
uniprot id: C7P4D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

485914:HMUK RS05595
gene id: 485914:HMUK_RS05595
uniprot id: C7P270
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

485914:HMUK RS05090
gene id: 485914:HMUK_RS05090
uniprot id: C7P1I6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

485914:HMUK RS11060
gene id: 485914:HMUK_RS11060
uniprot id: C7NXH3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A 'suicide' enzyme that participates in biotin synthesis. Catalyzes the formation of (S)-8-amino-7-oxononanoate (DAN-carbamic acid) from (7R,8S)-8-amino-7-(carboxyamino)nonanoate (DAN), a function equivalent to the cannonical BioA reaction and the first half-reaction of BioD. The cellular requirement for biotin is thought be low enough that this single turnover enzyme supplies a sufficient amount of the cofactor. Overall it catalyzes three reactions: formation of a covalent linkage with 8-amino-7-oxononanoate to yield a BioU-DAN conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-DAN-carbamic acid, and release of DAN-carbamic acid using NAD(P)+.
messages: Belongs to the BioU family.
messages: In cannonical biotin synthesis a pimeloyl-conjugate is transformed into biotin by the subsequent action of BioF, BioA, BioD and BioB. This enzyme replaces BioA and performs the first half-reaction of BioD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

485914:HMUK RS16175
gene id: 485914:HMUK_RS16175
uniprot id: C7P542
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.

485914:HMUK RS03960
gene id: 485914:HMUK_RS03960
uniprot id: C7P0I4
names: Similarity
messages: Belongs to the RutC family.

485914:HMUK RS08760
gene id: 485914:HMUK_RS08760
uniprot id: C7P4C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

485914:HMUK RS06575
gene id: 485914:HMUK_RS06575
uniprot id: C7P328
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

485914:HMUK RS11215
gene id: 485914:HMUK_RS11215
uniprot id: C7NXK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

485914:HMUK RS03340
gene id: 485914:HMUK_RS03340
uniprot id: C7NZS2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

485914:HMUK RS07140
gene id: 485914:HMUK_RS07140
uniprot id: C7P3E2
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

485914:HMUK RS01535
gene id: 485914:HMUK_RS01535
uniprot id: C7NXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS12120
gene id: 485914:HMUK_RS12120
uniprot id: C7NYS9
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

485914:HMUK RS01410
gene id: 485914:HMUK_RS01410
uniprot id: C7NX79
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

485914:HMUK RS12565
gene id: 485914:HMUK_RS12565
uniprot id: C7NZ13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

485914:HMUK RS01740
gene id: 485914:HMUK_RS01740
uniprot id: C7NXS2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

485914:HMUK RS07375
gene id: 485914:HMUK_RS07375
uniprot id: C7P3I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

485914:HMUK RS07350
gene id: 485914:HMUK_RS07350
uniprot id: C7P3I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

485914:HMUK RS00210
gene id: 485914:HMUK_RS00210
uniprot id: C7NVS9
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

485914:HMUK RS10505
gene id: 485914:HMUK_RS10505
uniprot id: C7NWT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

485914:HMUK RS07770
gene id: 485914:HMUK_RS07770
uniprot id: C7P3S0
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

485914:HMUK RS13390
gene id: 485914:HMUK_RS13390
uniprot id: C7P075
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

485914:HMUK RS11095
gene id: 485914:HMUK_RS11095
uniprot id: C7NXI0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

485914:HMUK RS00955
gene id: 485914:HMUK_RS00955
uniprot id: C7NWY2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

485914:HMUK RS03175
gene id: 485914:HMUK_RS03175
uniprot id: C7NZB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

485914:HMUK RS10930
gene id: 485914:HMUK_RS10930
uniprot id: C7NXE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS08290
gene id: 485914:HMUK_RS08290
uniprot id: C7P426
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

485914:HMUK RS08565
gene id: 485914:HMUK_RS08565
uniprot id: C7P481
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

485914:HMUK RS08715
gene id: 485914:HMUK_RS08715
uniprot id: C7P4B3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS05540
gene id: 485914:HMUK_RS05540
uniprot id: C7P258
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

485914:HMUK RS01785
gene id: 485914:HMUK_RS01785
uniprot id: C7NXT2
names: Subcellular Location Annotation
messages: Cytoplasm

485914:HMUK RS02795
gene id: 485914:HMUK_RS02795
uniprot id: C7NZ39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

485914:HMUK RS07790
gene id: 485914:HMUK_RS07790
uniprot id: C7P3S4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS13275
gene id: 485914:HMUK_RS13275
uniprot id: C7P050
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Cytoplasm

485914:HMUK RS14455
gene id: 485914:HMUK_RS14455
uniprot id: C7P172
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate ammonia-lyase family.
messages: Homodimer.

485914:HMUK RS14755
gene id: 485914:HMUK_RS14755
uniprot id: C7P1Q8
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS12595
gene id: 485914:HMUK_RS12595
uniprot id: C7NZ19
names: Similarity
messages: Belongs to the cytochrome P450 family.

485914:HMUK RS02385
gene id: 485914:HMUK_RS02385
uniprot id: C7NYI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

485914:HMUK RS13470
gene id: 485914:HMUK_RS13470
uniprot id: C7P092
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

485914:HMUK RS14725
gene id: 485914:HMUK_RS14725
uniprot id: C7P1Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

485914:HMUK RS15630
gene id: 485914:HMUK_RS15630
uniprot id: C7P4T5
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.

485914:HMUK RS11070
gene id: 485914:HMUK_RS11070
uniprot id: C7NXH5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

485914:HMUK RS07405
gene id: 485914:HMUK_RS07405
uniprot id: C7P3J5
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS07245
gene id: 485914:HMUK_RS07245
uniprot id: C7P3G1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS12890
gene id: 485914:HMUK_RS12890
uniprot id: C7NZJ9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

485914:HMUK RS02710
gene id: 485914:HMUK_RS02710
uniprot id: C7NZ22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Homodimer.

485914:HMUK RS14445
gene id: 485914:HMUK_RS14445
uniprot id: C7P170
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylamine corrinoid protein family.
messages: Belongs to the methylaspartate mutase GlmS subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.

485914:HMUK RS15485
gene id: 485914:HMUK_RS15485
uniprot id: C7P2I7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485914:HMUK RS05570
gene id: 485914:HMUK_RS05570
uniprot id: C7P265
names: Similarity
messages: Belongs to the NAD synthetase family.

485914:HMUK RS08865
gene id: 485914:HMUK_RS08865
uniprot id: C7P4E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

485914:HMUK RS15175
gene id: 485914:HMUK_RS15175
uniprot id: C7P2C2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

485914:HMUK RS09355
gene id: 485914:HMUK_RS09355
uniprot id: C7P4P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

485914:HMUK RS01295
gene id: 485914:HMUK_RS01295
uniprot id: C7NX52
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

485914:HMUK RS08705
gene id: 485914:HMUK_RS08705
uniprot id: C7P4B0
names: Similarity
messages: Belongs to the UPF0045 family.

485914:HMUK RS14160
gene id: 485914:HMUK_RS14160
uniprot id: C7P112
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

485914:HMUK RS11430
gene id: 485914:HMUK_RS11430
uniprot id: C7NY21
names: Similarity
messages: Belongs to the HerA family.

485914:HMUK RS10080
gene id: 485914:HMUK_RS10080
uniprot id: C7NWJ8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

485914:HMUK RS05680
gene id: 485914:HMUK_RS05680
uniprot id: C7P288
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS08890
gene id: 485914:HMUK_RS08890
uniprot id: C7P4E7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

485914:HMUK RS07080
gene id: 485914:HMUK_RS07080
uniprot id: C7P3C9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

485914:HMUK RS13515
gene id: 485914:HMUK_RS13515
uniprot id: C7P0A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

485914:HMUK RS12365
gene id: 485914:HMUK_RS12365
uniprot id: C7NYX7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

485914:HMUK RS11145
gene id: 485914:HMUK_RS11145
uniprot id: C7NXJ0
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS14740
gene id: 485914:HMUK_RS14740
uniprot id: C7P1Q5
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

485914:HMUK RS06135
gene id: 485914:HMUK_RS06135
uniprot id: C7P2U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

485914:HMUK RS03470
gene id: 485914:HMUK_RS03470
uniprot id: C7NZV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

485914:HMUK RS15760
gene id: 485914:HMUK_RS15760
uniprot id: C7P4W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

485914:HMUK RS12620
gene id: 485914:HMUK_RS12620
uniprot id: C7NZE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

485914:HMUK RS08995
gene id: 485914:HMUK_RS08995
uniprot id: C7P4G8
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS08855
gene id: 485914:HMUK_RS08855
uniprot id: C7P4E0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

485914:HMUK RS15225
gene id: 485914:HMUK_RS15225
uniprot id: C7P2D3
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS11165
gene id: 485914:HMUK_RS11165
uniprot id: C7NXJ4
names: Similarity
messages: Belongs to the GARS family.

485914:HMUK RS10200
gene id: 485914:HMUK_RS10200
uniprot id: C7NWM4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

485914:HMUK RS12575
gene id: 485914:HMUK_RS12575
uniprot id: C7NZ15
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

485914:HMUK RS03955
gene id: 485914:HMUK_RS03955
uniprot id: C7P0I3
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

485914:HMUK RS11790
gene id: 485914:HMUK_RS11790
uniprot id: C7NY92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

485914:HMUK RS13855
gene id: 485914:HMUK_RS13855
uniprot id: C7P0V1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS11590
gene id: 485914:HMUK_RS11590
uniprot id: C7NY51
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

485914:HMUK RS11645
gene id: 485914:HMUK_RS11645
uniprot id: C7NY62
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

485914:HMUK RS12785
gene id: 485914:HMUK_RS12785
uniprot id: C7NZH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

485914:HMUK RS01890
gene id: 485914:HMUK_RS01890
uniprot id: C7NXV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
messages: Homotetramer.

485914:HMUK RS03445
gene id: 485914:HMUK_RS03445
uniprot id: C7NZU4
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS14690
gene id: 485914:HMUK_RS14690
uniprot id: C7P1P5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

485914:HMUK RS13555
gene id: 485914:HMUK_RS13555
uniprot id: C7P0B1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485914:HMUK RS02440
gene id: 485914:HMUK_RS02440
uniprot id: C7NYJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

485914:HMUK RS06290
gene id: 485914:HMUK_RS06290
uniprot id: C7P2X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

485914:HMUK RS07030
gene id: 485914:HMUK_RS07030
uniprot id: C7P3B7
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS11770
gene id: 485914:HMUK_RS11770
uniprot id: C7NY88
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

485914:HMUK RS00095
gene id: 485914:HMUK_RS00095
uniprot id: C7NVQ5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

485914:HMUK RS10925
gene id: 485914:HMUK_RS10925
uniprot id: C7NXE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS12605
gene id: 485914:HMUK_RS12605
uniprot id: C7NZ21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS10345
gene id: 485914:HMUK_RS10345
uniprot id: C7NWQ2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

485914:HMUK RS06820
gene id: 485914:HMUK_RS06820
uniprot id: C7P379
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

485914:HMUK RS13230
gene id: 485914:HMUK_RS13230
uniprot id: C7NZR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

485914:HMUK RS10800
gene id: 485914:HMUK_RS10800
uniprot id: C7NXC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

485914:HMUK RS05340
gene id: 485914:HMUK_RS05340
uniprot id: C7P217
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

485914:HMUK RS12870
gene id: 485914:HMUK_RS12870
uniprot id: C7NZJ5
names: Function
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

485914:HMUK RS07695
gene id: 485914:HMUK_RS07695
uniprot id: C7P3Q4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

485914:HMUK RS04330
gene id: 485914:HMUK_RS04330
uniprot id: C7P0Q8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS04100
gene id: 485914:HMUK_RS04100
uniprot id: C7P0L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

485914:HMUK RS04660
gene id: 485914:HMUK_RS04660
uniprot id: C7P1A3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

485914:HMUK RS01755
gene id: 485914:HMUK_RS01755
uniprot id: C7NXS5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

485914:HMUK RS10730
gene id: 485914:HMUK_RS10730
uniprot id: C7NXA6
names: Similarity
messages: Belongs to the UPF0179 family.

485914:HMUK RS08825
gene id: 485914:HMUK_RS08825
uniprot id: C7P4D4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS14065
gene id: 485914:HMUK_RS14065
uniprot id: C7P0Z2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

485914:HMUK RS02575
gene id: 485914:HMUK_RS02575
uniprot id: C7NYM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

485914:HMUK RS01590
gene id: 485914:HMUK_RS01590
uniprot id: C7NXP1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

485914:HMUK RS01450
gene id: 485914:HMUK_RS01450
uniprot id: C7NX87
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

485914:HMUK RS08800
gene id: 485914:HMUK_RS08800
uniprot id: C7P4C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS07755
gene id: 485914:HMUK_RS07755
uniprot id: C7P3R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

485914:HMUK RS15550
gene id: 485914:HMUK_RS15550
uniprot id: C7P2K0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

485914:HMUK RS10950
gene id: 485914:HMUK_RS10950
uniprot id: C7NXE9
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

485914:HMUK RS14145
gene id: 485914:HMUK_RS14145
uniprot id: C7P109
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

485914:HMUK RS07420
gene id: 485914:HMUK_RS07420
uniprot id: C7P3J8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS09935
gene id: 485914:HMUK_RS09935
uniprot id: C7NW51
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

485914:HMUK RS04345
gene id: 485914:HMUK_RS04345
uniprot id: C7P0R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

485914:HMUK RS04425
gene id: 485914:HMUK_RS04425
uniprot id: C7P0S7
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS13780
gene id: 485914:HMUK_RS13780
uniprot id: C7P0F9
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

485914:HMUK RS00065
gene id: 485914:HMUK_RS00065
uniprot id: C7NVP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

485914:HMUK RS04640
gene id: 485914:HMUK_RS04640
uniprot id: C7P199
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS10050
gene id: 485914:HMUK_RS10050
uniprot id: C7NW72
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

485914:HMUK RS16380
gene id: 485914:HMUK_RS16380
uniprot id: C7P4R2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS12080
gene id: 485914:HMUK_RS12080
uniprot id: C7NYS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

485914:HMUK RS10445
gene id: 485914:HMUK_RS10445
uniprot id: C7NWS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

485914:HMUK RS09230
gene id: 485914:HMUK_RS09230
uniprot id: C7P4L8
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS00060
gene id: 485914:HMUK_RS00060
uniprot id: C7NVP8
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

485914:HMUK RS15335
gene id: 485914:HMUK_RS15335
uniprot id: C7P2F6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

485914:HMUK RS00075
gene id: 485914:HMUK_RS00075
uniprot id: C7NVQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

485914:HMUK RS14180
gene id: 485914:HMUK_RS14180
uniprot id: C7P116
names: Similarity
messages: Belongs to the DtxR/MntR family.

485914:HMUK RS15035
gene id: 485914:HMUK_RS15035
uniprot id: C7P1W8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

485914:HMUK RS11785
gene id: 485914:HMUK_RS11785
uniprot id: C7NY91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS14685
gene id: 485914:HMUK_RS14685
uniprot id: C7P1P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

485914:HMUK RS00650
gene id: 485914:HMUK_RS00650
uniprot id: C7NWE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485914:HMUK RS08840
gene id: 485914:HMUK_RS08840
uniprot id: C7P4D7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

485914:HMUK RS03250
gene id: 485914:HMUK_RS03250
uniprot id: C7NZC7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

485914:HMUK RS15250
gene id: 485914:HMUK_RS15250
uniprot id: C7P2D8
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

485914:HMUK RS07280
gene id: 485914:HMUK_RS07280
uniprot id: C7P3H0
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

485914:HMUK RS07750
gene id: 485914:HMUK_RS07750
uniprot id: C7P3R6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

485914:HMUK RS08400
gene id: 485914:HMUK_RS08400
uniprot id: C7P448
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS04035
gene id: 485914:HMUK_RS04035
uniprot id: C7P0J8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS13960
gene id: 485914:HMUK_RS13960
uniprot id: C7P0X1
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

485914:HMUK RS12510
gene id: 485914:HMUK_RS12510
uniprot id: C7NZ04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

485914:HMUK RS04780
gene id: 485914:HMUK_RS04780
uniprot id: C7P1C6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

485914:HMUK RS04400
gene id: 485914:HMUK_RS04400
uniprot id: C7P0S2
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

485914:HMUK RS09265
gene id: 485914:HMUK_RS09265
uniprot id: C7P4M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS03925
gene id: 485914:HMUK_RS03925
uniprot id: C7P0H4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

485914:HMUK RS01160
gene id: 485914:HMUK_RS01160
uniprot id: C7NX24
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

485914:HMUK RS08765
gene id: 485914:HMUK_RS08765
uniprot id: C7P4C2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

485914:HMUK RS11805
gene id: 485914:HMUK_RS11805
uniprot id: C7NY94
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS13710
gene id: 485914:HMUK_RS13710
uniprot id: C7P0E5
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

485914:HMUK RS02360
gene id: 485914:HMUK_RS02360
uniprot id: C7NYI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

485914:HMUK RS04675
gene id: 485914:HMUK_RS04675
uniprot id: C7P1A6
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

485914:HMUK RS08500
gene id: 485914:HMUK_RS08500
uniprot id: C7P467
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS08530
gene id: 485914:HMUK_RS08530
uniprot id: C7P474
names: Similarity
messages: Belongs to the LarC family.

485914:HMUK RS02640
gene id: 485914:HMUK_RS02640
uniprot id: C7NYN5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

485914:HMUK RS15620
gene id: 485914:HMUK_RS15620
uniprot id: C7P4T3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS05725
gene id: 485914:HMUK_RS05725
uniprot id: C7P297
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

485914:HMUK RS14510
gene id: 485914:HMUK_RS14510
uniprot id: C7P1K8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS07705
gene id: 485914:HMUK_RS07705
uniprot id: C7P3Q6
names: Similarity
messages: Belongs to the Ahb/Nir family.

485914:HMUK RS04085
gene id: 485914:HMUK_RS04085
uniprot id: C7P0K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

485914:HMUK RS04740
gene id: 485914:HMUK_RS04740
uniprot id: C7P1B8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

485914:HMUK RS11955
gene id: 485914:HMUK_RS11955
uniprot id: C7NYC5
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

485914:HMUK RS12640
gene id: 485914:HMUK_RS12640
uniprot id: C7NZF0
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

485914:HMUK RS13730
gene id: 485914:HMUK_RS13730
uniprot id: C7P0E9
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

485914:HMUK RS12525
gene id: 485914:HMUK_RS12525
uniprot id: C7NZ06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

485914:HMUK RS00235
gene id: 485914:HMUK_RS00235
uniprot id: C7NVT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

485914:HMUK RS01365
gene id: 485914:HMUK_RS01365
uniprot id: C7NX70
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS04430
gene id: 485914:HMUK_RS04430
uniprot id: C7P0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

485914:HMUK RS06460
gene id: 485914:HMUK_RS06460
uniprot id: C7P305
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

485914:HMUK RS06420
gene id: 485914:HMUK_RS06420
uniprot id: C7P2Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

485914:HMUK RS03975
gene id: 485914:HMUK_RS03975
uniprot id: C7P0I6
names: Similarity
messages: Belongs to the citrate synthase family.

485914:HMUK RS02955
gene id: 485914:HMUK_RS02955
uniprot id: C7NZ71
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

485914:HMUK RS12550
gene id: 485914:HMUK_RS12550
uniprot id: C7NZ10
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

485914:HMUK RS12630
gene id: 485914:HMUK_RS12630
uniprot id: C7NZE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

485914:HMUK RS02505
gene id: 485914:HMUK_RS02505
uniprot id: C7NYL1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS07365
gene id: 485914:HMUK_RS07365
uniprot id: C7P3I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

485914:HMUK RS08770
gene id: 485914:HMUK_RS08770
uniprot id: C7P4C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

485914:HMUK RS12275
gene id: 485914:HMUK_RS12275
uniprot id: C7NYW0
names: Similarity
messages: Belongs to the DNA photolyase family.

485914:HMUK RS05190
gene id: 485914:HMUK_RS05190
uniprot id: C7P1Y6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

485914:HMUK RS08755
gene id: 485914:HMUK_RS08755
uniprot id: C7P4C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

485914:HMUK RS15000
gene id: 485914:HMUK_RS15000
uniprot id: C7P1W1
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS00900
gene id: 485914:HMUK_RS00900
uniprot id: C7NWJ5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

485914:HMUK RS14025
gene id: 485914:HMUK_RS14025
uniprot id: C7P0Y4
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

485914:HMUK RS05650
gene id: 485914:HMUK_RS05650
uniprot id: C7P282
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

485914:HMUK RS06795
gene id: 485914:HMUK_RS06795
uniprot id: C7P374
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

485914:HMUK RS05590
gene id: 485914:HMUK_RS05590
uniprot id: C7P269
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

485914:HMUK RS11600
gene id: 485914:HMUK_RS11600
uniprot id: C7NY53
names: Similarity
messages: Belongs to the FUN14 family.

485914:HMUK RS04845
gene id: 485914:HMUK_RS04845
uniprot id: C7P1D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

485914:HMUK RS03285
gene id: 485914:HMUK_RS03285
uniprot id: C7NZD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

485914:HMUK RS10035
gene id: 485914:HMUK_RS10035
uniprot id: C7NW69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

485914:HMUK RS01810
gene id: 485914:HMUK_RS01810
uniprot id: C7NXU0
names: Subcellular Location Annotation
messages: Cytoplasm

485914:HMUK RS12175
gene id: 485914:HMUK_RS12175
uniprot id: C7NYU0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS08570
gene id: 485914:HMUK_RS08570
uniprot id: C7P482
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS04075
gene id: 485914:HMUK_RS04075
uniprot id: C7P0K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

485914:HMUK RS01850
gene id: 485914:HMUK_RS01850
uniprot id: C7NXU8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS12555
gene id: 485914:HMUK_RS12555
uniprot id: C7NZ11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

485914:HMUK RS14080
gene id: 485914:HMUK_RS14080
uniprot id: C7P0Z6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS03620
gene id: 485914:HMUK_RS03620
uniprot id: C7NZY1
names: Similarity
messages: Belongs to the aspartokinase family.

485914:HMUK RS13765
gene id: 485914:HMUK_RS13765
uniprot id: C7P0F6
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

485914:HMUK RS12865
gene id: 485914:HMUK_RS12865
uniprot id: C7NZJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

485914:HMUK RS05280
gene id: 485914:HMUK_RS05280
uniprot id: C7P204
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

485914:HMUK RS06375
gene id: 485914:HMUK_RS06375
uniprot id: C7P2Y8
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

485914:HMUK RS11610
gene id: 485914:HMUK_RS11610
uniprot id: C7NY55
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS08780
gene id: 485914:HMUK_RS08780
uniprot id: C7P4C5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

485914:HMUK RS00950
gene id: 485914:HMUK_RS00950
uniprot id: C7NWY1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

485914:HMUK RS08435
gene id: 485914:HMUK_RS08435
uniprot id: C7P454
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS03795
gene id: 485914:HMUK_RS03795
uniprot id: C7P019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

485914:HMUK RS12675
gene id: 485914:HMUK_RS12675
uniprot id: C7NZF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

485914:HMUK RS12475
gene id: 485914:HMUK_RS12475
uniprot id: C7NYZ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS12980
gene id: 485914:HMUK_RS12980
uniprot id: C7NZL7
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

485914:HMUK RS14230
gene id: 485914:HMUK_RS14230
uniprot id: C7P125
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

485914:HMUK RS03290
gene id: 485914:HMUK_RS03290
uniprot id: C7NZD5
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

485914:HMUK RS07875
gene id: 485914:HMUK_RS07875
uniprot id: C7P3U1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

485914:HMUK RS04800
gene id: 485914:HMUK_RS04800
uniprot id: C7P1D0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS12530
gene id: 485914:HMUK_RS12530
uniprot id: C7NZ07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

485914:HMUK RS11615
gene id: 485914:HMUK_RS11615
uniprot id: C7NY56
names: Similarity
messages: Belongs to the acylphosphatase family.

485914:HMUK RS11225
gene id: 485914:HMUK_RS11225
uniprot id: C7NXK6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS08885
gene id: 485914:HMUK_RS08885
uniprot id: C7P4E6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

485914:HMUK RS08465
gene id: 485914:HMUK_RS08465
uniprot id: C7P461
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
messages: Tetramer of two components I and two components II.

485914:HMUK RS13310
gene id: 485914:HMUK_RS13310
uniprot id: C7P059
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

485914:HMUK RS15050
gene id: 485914:HMUK_RS15050
uniprot id: C7P1X1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

485914:HMUK RS10630
gene id: 485914:HMUK_RS10630
uniprot id: C7NWW0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

485914:HMUK RS05870
gene id: 485914:HMUK_RS05870
uniprot id: C7P2N6
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS07605
gene id: 485914:HMUK_RS07605
uniprot id: C7P3N7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

485914:HMUK RS10845
gene id: 485914:HMUK_RS10845
uniprot id: C7NXC8
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

485914:HMUK RS16360
gene id: 485914:HMUK_RS16360
uniprot id: C7P584
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

485914:HMUK RS15730
gene id: 485914:HMUK_RS15730
uniprot id: C7P4V4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

485914:HMUK RS05855
gene id: 485914:HMUK_RS05855
uniprot id: C7P2N3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

485914:HMUK RS04110
gene id: 485914:HMUK_RS04110
uniprot id: C7P0L4
names: Subcellular Location Annotation
messages: Membrane

485914:HMUK RS05395
gene id: 485914:HMUK_RS05395
uniprot id: C7P229
names: Similarity
messages: Belongs to the phosphohexose mutase family.

485914:HMUK RS12140
gene id: 485914:HMUK_RS12140
uniprot id: C7NYT3
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS06645
gene id: 485914:HMUK_RS06645
uniprot id: C7P342
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

485914:HMUK RS09000
gene id: 485914:HMUK_RS09000
uniprot id: C7P4G9
names: Function
messages: Part of a potassium transport system.

485914:HMUK RS02075
gene id: 485914:HMUK_RS02075
uniprot id: C7NXZ6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

485914:HMUK RS05035
gene id: 485914:HMUK_RS05035
uniprot id: C7P1H4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

485914:HMUK RS01655
gene id: 485914:HMUK_RS01655
uniprot id: C7NXQ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

485914:HMUK RS02650
gene id: 485914:HMUK_RS02650
uniprot id: C7NYN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm