47304:DFR88 RS10570
gene id: 47304:DFR88_RS10570
uniprot id: A0A4D8RVC8
names: Similarity
messages: Belongs to the glutaredoxin family.

47304:DFR88 RS06560
gene id: 47304:DFR88_RS06560
uniprot id: A0A4D8S3L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

47304:DFR88 RS09910
gene id: 47304:DFR88_RS09910
uniprot id: A0A4D8RUC2
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

47304:DFR88 RS09475
gene id: 47304:DFR88_RS09475
uniprot id: A0A4D8S782
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS00660
gene id: 47304:DFR88_RS00660
uniprot id: A0A4D8RPY0
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

47304:DFR88 RS08300
gene id: 47304:DFR88_RS08300
uniprot id: A0A4D8RU73
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

47304:DFR88 RS05105
gene id: 47304:DFR88_RS05105
uniprot id: A0A4D8S4Z5
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS05275
gene id: 47304:DFR88_RS05275
uniprot id: A0A4D8RW47
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

47304:DFR88 RS01990
gene id: 47304:DFR88_RS01990
uniprot id: A0A4D8S3F9
names: Similarity
messages: Belongs to the HupF/HypC family.

47304:DFR88 RS01705
gene id: 47304:DFR88_RS01705
uniprot id: A0A4D8S3B0
names: Similarity
messages: Belongs to the selenium-binding protein family.

47304:DFR88 RS03110
gene id: 47304:DFR88_RS03110
uniprot id: A0A4D8RV27
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

47304:DFR88 RS03955
gene id: 47304:DFR88_RS03955
uniprot id: A0A4D8RXQ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS10720
gene id: 47304:DFR88_RS10720
uniprot id: A0A4D8S5R1
names: Similarity
messages: Belongs to the citrate synthase family.

47304:DFR88 RS06130
gene id: 47304:DFR88_RS06130
uniprot id: A0A4D8SEL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

47304:DFR88 RS07920
gene id: 47304:DFR88_RS07920
uniprot id: A0A4D8RZT6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

47304:DFR88 RS04590
gene id: 47304:DFR88_RS04590
uniprot id: A0A4D8RVT1
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS11755
gene id: 47304:DFR88_RS11755
uniprot id: A0A4D8S181
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

47304:DFR88 RS09920
gene id: 47304:DFR88_RS09920
uniprot id: A0A4D8RV15
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

47304:DFR88 RS09785
gene id: 47304:DFR88_RS09785
uniprot id: A0A4D8SGS1
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS01515
gene id: 47304:DFR88_RS01515
uniprot id: A0A4D8S1L0
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS08145
gene id: 47304:DFR88_RS08145
uniprot id: A0A4D8RXI8
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

47304:DFR88 RS09510
gene id: 47304:DFR88_RS09510
uniprot id: A0A4D8S713
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

47304:DFR88 RS11090
gene id: 47304:DFR88_RS11090
uniprot id: A0A4D8RUZ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS06260
gene id: 47304:DFR88_RS06260
uniprot id: A0A4D8RSP8
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

47304:DFR88 RS04635
gene id: 47304:DFR88_RS04635
uniprot id: A0A4D8S6H7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

47304:DFR88 RS11220
gene id: 47304:DFR88_RS11220
uniprot id: A0A4D8RZ03
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

47304:DFR88 RS06835
gene id: 47304:DFR88_RS06835
uniprot id: A0A4D8RZ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

47304:DFR88 RS01310
gene id: 47304:DFR88_RS01310
uniprot id: A0A4D8RQ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS06540
gene id: 47304:DFR88_RS06540
uniprot id: A0A4D8S1R5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

47304:DFR88 RS09615
gene id: 47304:DFR88_RS09615
uniprot id: A0A4D8S524
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

47304:DFR88 RS07060
gene id: 47304:DFR88_RS07060
uniprot id: A0A4D8S1Z7
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

47304:DFR88 RS06670
gene id: 47304:DFR88_RS06670
uniprot id: A0A4D8S3N0
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

47304:DFR88 RS00615
gene id: 47304:DFR88_RS00615
uniprot id: A0A4D8RQG9
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS06940
gene id: 47304:DFR88_RS06940
uniprot id: A0A4D8S3S3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

47304:DFR88 RS04385
gene id: 47304:DFR88_RS04385
uniprot id: A0A4D8SDG5
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

47304:DFR88 RS05520
gene id: 47304:DFR88_RS05520
uniprot id: A0A4D8S569
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS00420
gene id: 47304:DFR88_RS00420
uniprot id: A0A4D8RW09
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

47304:DFR88 RS08530
gene id: 47304:DFR88_RS08530
uniprot id: A0A4D8RW05
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

47304:DFR88 RS11155
gene id: 47304:DFR88_RS11155
uniprot id: A0A4D8RYZ6
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

47304:DFR88 RS05720
gene id: 47304:DFR88_RS05720
uniprot id: A0A4D8S184
names: Similarity
messages: Belongs to the peptidase M24B family.

47304:DFR88 RS02530
gene id: 47304:DFR88_RS02530
uniprot id: A0A4D8SII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

47304:DFR88 RS06125
gene id: 47304:DFR88_RS06125
uniprot id: A0A4D8RYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

47304:DFR88 RS07400
gene id: 47304:DFR88_RS07400
uniprot id: A0A4D8S406
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

47304:DFR88 RS03010
gene id: 47304:DFR88_RS03010
uniprot id: A0A4D8RX88
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

47304:DFR88 RS06760
gene id: 47304:DFR88_RS06760
uniprot id: A0A4D8S5Y1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

47304:DFR88 RS08555
gene id: 47304:DFR88_RS08555
uniprot id: A0A4D8SG20
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

47304:DFR88 RS00510
gene id: 47304:DFR88_RS00510
uniprot id: A0A4D8RQF1
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS08245
gene id: 47304:DFR88_RS08245
uniprot id: A0A4D8RU62
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

47304:DFR88 RS06210
gene id: 47304:DFR88_RS06210
uniprot id: A0A4D8RT86
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

47304:DFR88 RS01475
gene id: 47304:DFR88_RS01475
uniprot id: A0A4D8RQB1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

47304:DFR88 RS06520
gene id: 47304:DFR88_RS06520
uniprot id: A0A4D8S6L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS07010
gene id: 47304:DFR88_RS07010
uniprot id: A0A4D8S1Y7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS11180
gene id: 47304:DFR88_RS11180
uniprot id: A0A4D8SHQ5
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS10375
gene id: 47304:DFR88_RS10375
uniprot id: A0A4D8S3T8
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS05915
gene id: 47304:DFR88_RS05915
uniprot id: A0A4D8S2Q0
names: Similarity
messages: Belongs to the glutaredoxin family.

47304:DFR88 RS11920
gene id: 47304:DFR88_RS11920
uniprot id: A0A4D8S8K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS04905
gene id: 47304:DFR88_RS04905
uniprot id: A0A4D8S2W7
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS08630
gene id: 47304:DFR88_RS08630
uniprot id: A0A4D8RTR2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

47304:DFR88 RS07685
gene id: 47304:DFR88_RS07685
uniprot id: A0A4D8RTC6
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

47304:DFR88 RS10170
gene id: 47304:DFR88_RS10170
uniprot id: A0A4D8RYG5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

47304:DFR88 RS07500
gene id: 47304:DFR88_RS07500
uniprot id: A0A4D8SFJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

47304:DFR88 RS00975
gene id: 47304:DFR88_RS00975
uniprot id: A0A4D8RQ24
names: Similarity
messages: Belongs to the class-I fumarase family.

47304:DFR88 RS07935
gene id: 47304:DFR88_RS07935
uniprot id: A0A4D8S2N4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

47304:DFR88 RS06625
gene id: 47304:DFR88_RS06625
uniprot id: A0A4D8S5V6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

47304:DFR88 RS03760
gene id: 47304:DFR88_RS03760
uniprot id: A0A4D8S1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

47304:DFR88 RS07055
gene id: 47304:DFR88_RS07055
uniprot id: A0A4D8S3Y5
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

47304:DFR88 RS08875
gene id: 47304:DFR88_RS08875
uniprot id: A0A4D8RZY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

47304:DFR88 RS08470
gene id: 47304:DFR88_RS08470
uniprot id: A0A4D8S6Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

47304:DFR88 RS09555
gene id: 47304:DFR88_RS09555
uniprot id: A0A4D8RWM4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

47304:DFR88 RS08635
gene id: 47304:DFR88_RS08635
uniprot id: A0A4D8S4L7
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

47304:DFR88 RS07980
gene id: 47304:DFR88_RS07980
uniprot id: A0A4D8RZU5
names: Similarity
messages: Belongs to the MCM family.

47304:DFR88 RS04415
gene id: 47304:DFR88_RS04415
uniprot id: A0A4D8RVP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS08260
gene id: 47304:DFR88_RS08260
uniprot id: A0A4D8RZM6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS04695
gene id: 47304:DFR88_RS04695
uniprot id: A0A4D8RRU0
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS05965
gene id: 47304:DFR88_RS05965
uniprot id: A0A4D8S3A1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS06390
gene id: 47304:DFR88_RS06390
uniprot id: A0A4D8RYY1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

47304:DFR88 RS03370
gene id: 47304:DFR88_RS03370
uniprot id: A0A4D8RXE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

47304:DFR88 RS11060
gene id: 47304:DFR88_RS11060
uniprot id: A0A4D8S0X5
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS07015
gene id: 47304:DFR88_RS07015
uniprot id: A0A4D8RT17
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS00950
gene id: 47304:DFR88_RS00950
uniprot id: A0A4D8RWA5
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS03335
gene id: 47304:DFR88_RS03335
uniprot id: A0A4D8RZY1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

47304:DFR88 RS01155
gene id: 47304:DFR88_RS01155
uniprot id: A0A4D8SIF2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

47304:DFR88 RS09875
gene id: 47304:DFR88_RS09875
uniprot id: A0A4D8S589
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

47304:DFR88 RS09950
gene id: 47304:DFR88_RS09950
uniprot id: A0A4D8S575
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

47304:DFR88 RS11525
gene id: 47304:DFR88_RS11525
uniprot id: A0A4D8S144
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

47304:DFR88 RS08750
gene id: 47304:DFR88_RS08750
uniprot id: A0A4D8RUF2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

47304:DFR88 RS06315
gene id: 47304:DFR88_RS06315
uniprot id: A0A4D8S3H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

47304:DFR88 RS11480
gene id: 47304:DFR88_RS11480
uniprot id: A0A4D8SHW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

47304:DFR88 RS00605
gene id: 47304:DFR88_RS00605
uniprot id: A0A4D8RPX0
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS07145
gene id: 47304:DFR88_RS07145
uniprot id: A0A4D8S636
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS05835
gene id: 47304:DFR88_RS05835
uniprot id: A0A4D8RSE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

47304:DFR88 RS06275
gene id: 47304:DFR88_RS06275
uniprot id: A0A4D8RWK4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

47304:DFR88 RS02145
gene id: 47304:DFR88_RS02145
uniprot id: A0A4D8RUL9
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

47304:DFR88 RS03790
gene id: 47304:DFR88_RS03790
uniprot id: A0A4D8RXM5
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS05660
gene id: 47304:DFR88_RS05660
uniprot id: A0A4D8S386
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS08345
gene id: 47304:DFR88_RS08345
uniprot id: A0A4D8S4F8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

47304:DFR88 RS07420
gene id: 47304:DFR88_RS07420
uniprot id: A0A4D8S677
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

47304:DFR88 RS05830
gene id: 47304:DFR88_RS05830
uniprot id: A0A4D8S1A8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

47304:DFR88 RS05770
gene id: 47304:DFR88_RS05770
uniprot id: A0A4D8RZM4
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS08580
gene id: 47304:DFR88_RS08580
uniprot id: A0A4D8RUC4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

47304:DFR88 RS06305
gene id: 47304:DFR88_RS06305
uniprot id: A0A4D8RSQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

47304:DFR88 RS09925
gene id: 47304:DFR88_RS09925
uniprot id: A0A4D8RYC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

47304:DFR88 RS08870
gene id: 47304:DFR88_RS08870
uniprot id: A0A4D8S6X8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

47304:DFR88 RS06205
gene id: 47304:DFR88_RS06205
uniprot id: A0A4D8S3E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

47304:DFR88 RS07125
gene id: 47304:DFR88_RS07125
uniprot id: A0A4D8S3V7
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

47304:DFR88 RS09720
gene id: 47304:DFR88_RS09720
uniprot id: A0A4D8S0B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

47304:DFR88 RS07485
gene id: 47304:DFR88_RS07485
uniprot id: A0A4D8RZL7
names: Similarity
messages: Belongs to the MEMO1 family.

47304:DFR88 RS05475
gene id: 47304:DFR88_RS05475
uniprot id: A0A4D8S2N5
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

47304:DFR88 RS06910
gene id: 47304:DFR88_RS06910
uniprot id: A0A4D8RZ86
names: Similarity
messages: Belongs to the HerA family.

47304:DFR88 RS10725
gene id: 47304:DFR88_RS10725
uniprot id: A0A4D8RVF9
names: Similarity
messages: Belongs to the UPF0111 family.

47304:DFR88 RS08210
gene id: 47304:DFR88_RS08210
uniprot id: A0A4D8RZL6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

47304:DFR88 RS03005
gene id: 47304:DFR88_RS03005
uniprot id: A0A4D8S3X5
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

47304:DFR88 RS07345
gene id: 47304:DFR88_RS07345
uniprot id: A0A4D8RZA6
names: Similarity
messages: Belongs to the HerA family.

47304:DFR88 RS11095
gene id: 47304:DFR88_RS11095
uniprot id: A0A4D8S5Z2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

47304:DFR88 RS11100
gene id: 47304:DFR88_RS11100
uniprot id: A0A4D8RVM2
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS10235
gene id: 47304:DFR88_RS10235
uniprot id: A0A4D8S0J4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

47304:DFR88 RS05150
gene id: 47304:DFR88_RS05150
uniprot id: A0A4D8RSQ9
names: Similarity
messages: Belongs to the peptidase M1 family.

47304:DFR88 RS09855
gene id: 47304:DFR88_RS09855
uniprot id: A0A4D8S591
names: Similarity
messages: Belongs to the TrpF family.

47304:DFR88 RS03225
gene id: 47304:DFR88_RS03225
uniprot id: A0A4D8RRU4
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

47304:DFR88 RS07415
gene id: 47304:DFR88_RS07415
uniprot id: A0A4D8S6W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

47304:DFR88 RS01110
gene id: 47304:DFR88_RS01110
uniprot id: A0A4D8RWD8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

47304:DFR88 RS07045
gene id: 47304:DFR88_RS07045
uniprot id: A0A4D8RZB5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

47304:DFR88 RS04865
gene id: 47304:DFR88_RS04865
uniprot id: A0A4D8S2N6
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS06155
gene id: 47304:DFR88_RS06155
uniprot id: A0A4D8RT79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

47304:DFR88 RS09155
gene id: 47304:DFR88_RS09155
uniprot id: A0A4D8S4X5
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS09525
gene id: 47304:DFR88_RS09525
uniprot id: A0A4D8RY58
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

47304:DFR88 RS08460
gene id: 47304:DFR88_RS08460
uniprot id: A0A4D8SJ41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

47304:DFR88 RS06385
gene id: 47304:DFR88_RS06385
uniprot id: A0A4D8RYX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

47304:DFR88 RS04490
gene id: 47304:DFR88_RS04490
uniprot id: A0A4D8S1K6
names: Similarity
messages: Belongs to the WrbA family.

47304:DFR88 RS06300
gene id: 47304:DFR88_RS06300
uniprot id: A0A4D8S1K9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

47304:DFR88 RS04355
gene id: 47304:DFR88_RS04355
uniprot id: A0A4D8RSC6
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

47304:DFR88 RS03125
gene id: 47304:DFR88_RS03125
uniprot id: A0A4D8S6D9
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS03055
gene id: 47304:DFR88_RS03055
uniprot id: A0A4D8S3Y6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS09035
gene id: 47304:DFR88_RS09035
uniprot id: A0A4D8RUK6
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

47304:DFR88 RS07000
gene id: 47304:DFR88_RS07000
uniprot id: A0A4D8SF75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

47304:DFR88 RS11405
gene id: 47304:DFR88_RS11405
uniprot id: A0A4D8S8A8
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

47304:DFR88 RS07300
gene id: 47304:DFR88_RS07300
uniprot id: A0A4D8S2A2
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

47304:DFR88 RS05630
gene id: 47304:DFR88_RS05630
uniprot id: A0A4D8S6S6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

47304:DFR88 RS09830
gene id: 47304:DFR88_RS09830
uniprot id: A0A4D8S0U4
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

47304:DFR88 RS02065
gene id: 47304:DFR88_RS02065
uniprot id: A0A4D8S1V0
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS06510
gene id: 47304:DFR88_RS06510
uniprot id: A0A4D8S5T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS11520
gene id: 47304:DFR88_RS11520
uniprot id: A0A4D8S745
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

47304:DFR88 RS05495
gene id: 47304:DFR88_RS05495
uniprot id: A0A4D8S323
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

47304:DFR88 RS09340
gene id: 47304:DFR88_RS09340
uniprot id: A0A4D8S056
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

47304:DFR88 RS01090
gene id: 47304:DFR88_RS01090
uniprot id: A0A4D8S0F6
names: Similarity
messages: Belongs to the pirin family.

47304:DFR88 RS11820
gene id: 47304:DFR88_RS11820
uniprot id: A0A4D8SI81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

47304:DFR88 RS06720
gene id: 47304:DFR88_RS06720
uniprot id: A0A4D8RSX8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

47304:DFR88 RS07120
gene id: 47304:DFR88_RS07120
uniprot id: A0A4D8RT44
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

47304:DFR88 RS11925
gene id: 47304:DFR88_RS11925
uniprot id: A0A4D8S1A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS06950
gene id: 47304:DFR88_RS06950
uniprot id: A0A4D8RTL0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

47304:DFR88 RS00440
gene id: 47304:DFR88_RS00440
uniprot id: A0A4D8RYC6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

47304:DFR88 RS07450
gene id: 47304:DFR88_RS07450
uniprot id: A0A4D8RT91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS06825
gene id: 47304:DFR88_RS06825
uniprot id: A0A4D8S5Z1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

47304:DFR88 RS05775
gene id: 47304:DFR88_RS05775
uniprot id: A0A4D8S196
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

47304:DFR88 RS06240
gene id: 47304:DFR88_RS06240
uniprot id: A0A4D8SEP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

47304:DFR88 RS01645
gene id: 47304:DFR88_RS01645
uniprot id: A0A4D8RUC9
names: Similarity
messages: Belongs to the thymidylate kinase family.

47304:DFR88 RS01920
gene id: 47304:DFR88_RS01920
uniprot id: A0A4D8S4Q1
names: Similarity
messages: Belongs to the HupF/HypC family.

47304:DFR88 RS06705
gene id: 47304:DFR88_RS06705
uniprot id: A0A4D8SF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

47304:DFR88 RS11745
gene id: 47304:DFR88_RS11745
uniprot id: A0A4D8RZ79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

47304:DFR88 RS08660
gene id: 47304:DFR88_RS08660
uniprot id: A0A4D8S072
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS08715
gene id: 47304:DFR88_RS08715
uniprot id: A0A4D8S086
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS09360
gene id: 47304:DFR88_RS09360
uniprot id: A0A4D8SGI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS09575
gene id: 47304:DFR88_RS09575
uniprot id: A0A4D8S542
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

47304:DFR88 RS08290
gene id: 47304:DFR88_RS08290
uniprot id: A0A4D8RTK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

47304:DFR88 RS00985
gene id: 47304:DFR88_RS00985
uniprot id: A0A4D8S0C6
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

47304:DFR88 RS03750
gene id: 47304:DFR88_RS03750
uniprot id: A0A4D8S059
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

47304:DFR88 RS04115
gene id: 47304:DFR88_RS04115
uniprot id: A0A4D8RXT4
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

47304:DFR88 RS02160
gene id: 47304:DFR88_RS02160
uniprot id: A0A4D8RWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

47304:DFR88 RS03320
gene id: 47304:DFR88_RS03320
uniprot id: A0A4D8RXC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

47304:DFR88 RS02020
gene id: 47304:DFR88_RS02020
uniprot id: A0A4D8RQK1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

47304:DFR88 RS08650
gene id: 47304:DFR88_RS08650
uniprot id: A0A4D8S6T3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

47304:DFR88 RS05840
gene id: 47304:DFR88_RS05840
uniprot id: A0A4D8S387
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

47304:DFR88 RS08915
gene id: 47304:DFR88_RS08915
uniprot id: A0A4D8RXX0
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

47304:DFR88 RS01985
gene id: 47304:DFR88_RS01985
uniprot id: A0A4D8RUJ0
names: Similarity
messages: Belongs to the HupF/HypC family.

47304:DFR88 RS05405
gene id: 47304:DFR88_RS05405
uniprot id: A0A4D8SE23
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS04990
gene id: 47304:DFR88_RS04990
uniprot id: A0A4D8S4X0
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

47304:DFR88 RS09600
gene id: 47304:DFR88_RS09600
uniprot id: A0A4D8S093
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

47304:DFR88 RS08495
gene id: 47304:DFR88_RS08495
uniprot id: A0A4D8S4L1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

47304:DFR88 RS05115
gene id: 47304:DFR88_RS05115
uniprot id: A0A4D8RYA3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

47304:DFR88 RS06545
gene id: 47304:DFR88_RS06545
uniprot id: A0A4D8RVV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

47304:DFR88 RS06180
gene id: 47304:DFR88_RS06180
uniprot id: A0A4D8SEM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

47304:DFR88 RS08935
gene id: 47304:DFR88_RS08935
uniprot id: A0A4D8SJ55
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

47304:DFR88 RS00945
gene id: 47304:DFR88_RS00945
uniprot id: A0A4D8RZD1
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

47304:DFR88 RS09305
gene id: 47304:DFR88_RS09305
uniprot id: A0A4D8S4Y4
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

47304:DFR88 RS02780
gene id: 47304:DFR88_RS02780
uniprot id: A0A4D8S1E9
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

47304:DFR88 RS03575
gene id: 47304:DFR88_RS03575
uniprot id: A0A4D8RRZ6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

47304:DFR88 RS09780
gene id: 47304:DFR88_RS09780
uniprot id: A0A4D8S0T4
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

47304:DFR88 RS07570
gene id: 47304:DFR88_RS07570
uniprot id: A0A4D8SFK6
names: Similarity
messages: Belongs to the UPF0173 family.

47304:DFR88 RS07510
gene id: 47304:DFR88_RS07510
uniprot id: A0A4D8S2E2
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS05110
gene id: 47304:DFR88_RS05110
uniprot id: A0A4D8RYA4
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS05740
gene id: 47304:DFR88_RS05740
uniprot id: A0A4D8RWC3
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

47304:DFR88 RS10640
gene id: 47304:DFR88_RS10640
uniprot id: A0A4D8S1A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

47304:DFR88 RS11000
gene id: 47304:DFR88_RS11000
uniprot id: A0A4D8S838
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

47304:DFR88 RS07455
gene id: 47304:DFR88_RS07455
uniprot id: A0A4D8RWI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

47304:DFR88 RS06515
gene id: 47304:DFR88_RS06515
uniprot id: A0A4D8RYZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

47304:DFR88 RS10220
gene id: 47304:DFR88_RS10220
uniprot id: A0A4D8RYH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

47304:DFR88 RS10690
gene id: 47304:DFR88_RS10690
uniprot id: A0A4D8S0R4
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS07025
gene id: 47304:DFR88_RS07025
uniprot id: A0A4D8RTM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
messages: Homotetramer; dimer of dimers.

47304:DFR88 RS11325
gene id: 47304:DFR88_RS11325
uniprot id: A0A4D8RVQ5
names: Similarity
messages: Belongs to the RutC family.

47304:DFR88 RS09310
gene id: 47304:DFR88_RS09310
uniprot id: A0A4D8S3C7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

47304:DFR88 RS06980
gene id: 47304:DFR88_RS06980
uniprot id: A0A4D8RZ51
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS07430
gene id: 47304:DFR88_RS07430
uniprot id: A0A4D8RZK6
names: Similarity
messages: Belongs to the UPF0047 family.

47304:DFR88 RS09480
gene id: 47304:DFR88_RS09480
uniprot id: A0A4D8S074
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

47304:DFR88 RS01640
gene id: 47304:DFR88_RS01640
uniprot id: A0A4D8RR02
names: Similarity
messages: Belongs to the thymidylate kinase family.

47304:DFR88 RS05470
gene id: 47304:DFR88_RS05470
uniprot id: A0A4D8S353
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

47304:DFR88 RS07580
gene id: 47304:DFR88_RS07580
uniprot id: A0A4D8S2F9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

47304:DFR88 RS09860
gene id: 47304:DFR88_RS09860
uniprot id: A0A4D8RV05
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

47304:DFR88 RS06875
gene id: 47304:DFR88_RS06875
uniprot id: A0A4D8S2S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

47304:DFR88 RS11435
gene id: 47304:DFR88_RS11435
uniprot id: A0A4D8RV55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS08390
gene id: 47304:DFR88_RS08390
uniprot id: A0A4D8RTM4
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

47304:DFR88 RS06225
gene id: 47304:DFR88_RS06225
uniprot id: A0A4D8S5M2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

47304:DFR88 RS06320
gene id: 47304:DFR88_RS06320
uniprot id: A0A4D8RTA4
names: Similarity
messages: Belongs to the SDO1/SBDS family.

47304:DFR88 RS10415
gene id: 47304:DFR88_RS10415
uniprot id: A0A4D8S0L9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS08905
gene id: 47304:DFR88_RS08905
uniprot id: A0A4D8S4R4
names: Similarity
messages: Belongs to the glutaredoxin family.

47304:DFR88 RS06280
gene id: 47304:DFR88_RS06280
uniprot id: A0A4D8S5N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

47304:DFR88 RS08595
gene id: 47304:DFR88_RS08595
uniprot id: A0A4D8RZT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

47304:DFR88 RS05930
gene id: 47304:DFR88_RS05930
uniprot id: A0A4D8RYP1
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

47304:DFR88 RS03155
gene id: 47304:DFR88_RS03155
uniprot id: A0A4D8RZU7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

47304:DFR88 RS03765
gene id: 47304:DFR88_RS03765
uniprot id: A0A4D8RS27
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

47304:DFR88 RS05400
gene id: 47304:DFR88_RS05400
uniprot id: A0A4D8RYF1
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS07410
gene id: 47304:DFR88_RS07410
uniprot id: A0A4D8RX75
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

47304:DFR88 RS02960
gene id: 47304:DFR88_RS02960
uniprot id: A0A4D8SCP8
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

47304:DFR88 RS03630
gene id: 47304:DFR88_RS03630
uniprot id: A0A4D8RRB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

47304:DFR88 RS07065
gene id: 47304:DFR88_RS07065
uniprot id: A0A4D8RT33
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

47304:DFR88 RS09625
gene id: 47304:DFR88_RS09625
uniprot id: A0A4D8RU71
names: Similarity
messages: Belongs to the TFIIB family.

47304:DFR88 RS06500
gene id: 47304:DFR88_RS06500
uniprot id: A0A4D8RWQ5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

47304:DFR88 RS02615
gene id: 47304:DFR88_RS02615
uniprot id: A0A4D8S1B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

47304:DFR88 RS08340
gene id: 47304:DFR88_RS08340
uniprot id: A0A4D8RTL6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS00015
gene id: 47304:DFR88_RS00015
uniprot id: A0A4D8RTG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS08325
gene id: 47304:DFR88_RS08325
uniprot id: A0A4D8SFY2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

47304:DFR88 RS08450
gene id: 47304:DFR88_RS08450
uniprot id: A0A4D8S4H8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

47304:DFR88 RS05285
gene id: 47304:DFR88_RS05285
uniprot id: A0A4D8RYD8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

47304:DFR88 RS06245
gene id: 47304:DFR88_RS06245
uniprot id: A0A4D8S3J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

47304:DFR88 RS10175
gene id: 47304:DFR88_RS10175
uniprot id: A0A4D8S7L9
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

47304:DFR88 RS04470
gene id: 47304:DFR88_RS04470
uniprot id: A0A4D8RSE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS01655
gene id: 47304:DFR88_RS01655
uniprot id: A0A4D8RWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

47304:DFR88 RS05665
gene id: 47304:DFR88_RS05665
uniprot id: A0A4D8S175
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

47304:DFR88 RS07295
gene id: 47304:DFR88_RS07295
uniprot id: A0A4D8S436
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

47304:DFR88 RS07945
gene id: 47304:DFR88_RS07945
uniprot id: A0A4D8S489
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

47304:DFR88 RS00010
gene id: 47304:DFR88_RS00010
uniprot id: A0A4D8RQ61
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS00130
gene id: 47304:DFR88_RS00130
uniprot id: A0A4D8RQ77
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

47304:DFR88 RS06465
gene id: 47304:DFR88_RS06465
uniprot id: A0A4D8RYY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

47304:DFR88 RS09325
gene id: 47304:DFR88_RS09325
uniprot id: A0A4D8RUQ6
names: Similarity
messages: Belongs to the UPF0201 family.

47304:DFR88 RS08275
gene id: 47304:DFR88_RS08275
uniprot id: A0A4D8S1T4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS08730
gene id: 47304:DFR88_RS08730
uniprot id: A0A4D8S336
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS01380
gene id: 47304:DFR88_RS01380
uniprot id: A0A4D8RU76
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

47304:DFR88 RS08830
gene id: 47304:DFR88_RS08830
uniprot id: A0A4D8S4S0
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS07720
gene id: 47304:DFR88_RS07720
uniprot id: A0A4D8RZF3
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

47304:DFR88 RS05340
gene id: 47304:DFR88_RS05340
uniprot id: A0A4D8RYE4
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS08925
gene id: 47304:DFR88_RS08925
uniprot id: A0A4D8S6Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

47304:DFR88 RS09375
gene id: 47304:DFR88_RS09375
uniprot id: A0A4D8S3D4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

47304:DFR88 RS06290
gene id: 47304:DFR88_RS06290
uniprot id: A0A4D8RYV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

47304:DFR88 RS09915
gene id: 47304:DFR88_RS09915
uniprot id: A0A4D8S5A1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

47304:DFR88 RS11175
gene id: 47304:DFR88_RS11175
uniprot id: A0A4D8S1L9
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS10190
gene id: 47304:DFR88_RS10190
uniprot id: A0A4D8SH02
names: Similarity
messages: Belongs to the PDCD5 family.

47304:DFR88 RS07465
gene id: 47304:DFR88_RS07465
uniprot id: A0A4D8RTU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

47304:DFR88 RS05280
gene id: 47304:DFR88_RS05280
uniprot id: A0A4D8S533
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

47304:DFR88 RS06325
gene id: 47304:DFR88_RS06325
uniprot id: A0A4D8RWL6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

47304:DFR88 RS05925
gene id: 47304:DFR88_RS05925
uniprot id: A0A4D8RYQ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS03890
gene id: 47304:DFR88_RS03890
uniprot id: A0A4D8RVF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

47304:DFR88 RS05455
gene id: 47304:DFR88_RS05455
uniprot id: A0A4D8RYH1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

47304:DFR88 RS05860
gene id: 47304:DFR88_RS05860
uniprot id: A0A4D8S5E2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS08480
gene id: 47304:DFR88_RS08480
uniprot id: A0A4D8S6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

47304:DFR88 RS03105
gene id: 47304:DFR88_RS03105
uniprot id: A0A4D8RRS6
names: Caution
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS09505
gene id: 47304:DFR88_RS09505
uniprot id: A0A4D8RU52
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

47304:DFR88 RS08510
gene id: 47304:DFR88_RS08510
uniprot id: A0A4D8S572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

47304:DFR88 RS06165
gene id: 47304:DFR88_RS06165
uniprot id: A0A4D8S5K8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

47304:DFR88 RS04790
gene id: 47304:DFR88_RS04790
uniprot id: A0A4D8S6Q6
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS10060
gene id: 47304:DFR88_RS10060
uniprot id: A0A4D8S0Y7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS10130
gene id: 47304:DFR88_RS10130
uniprot id: A0A4D8S1W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

47304:DFR88 RS07865
gene id: 47304:DFR88_RS07865
uniprot id: A0A4D8S4B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

47304:DFR88 RS02865
gene id: 47304:DFR88_RS02865
uniprot id: A0A4D8S3V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

47304:DFR88 RS08655
gene id: 47304:DFR88_RS08655
uniprot id: A0A4D8RZU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

47304:DFR88 RS04730
gene id: 47304:DFR88_RS04730
uniprot id: A0A4D8SDL9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

47304:DFR88 RS04000
gene id: 47304:DFR88_RS04000
uniprot id: A0A4D8S4F2
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS04065
gene id: 47304:DFR88_RS04065
uniprot id: A0A4D8SDA9
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

47304:DFR88 RS07135
gene id: 47304:DFR88_RS07135
uniprot id: A0A4D8RWH5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS03135
gene id: 47304:DFR88_RS03135
uniprot id: A0A4D8RX90
names: Similarity
messages: Belongs to the band 7/mec-2 family.

47304:DFR88 RS08150
gene id: 47304:DFR88_RS08150
uniprot id: A0A4D8S6J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

47304:DFR88 RS07505
gene id: 47304:DFR88_RS07505
uniprot id: A0A4D8S464
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

47304:DFR88 RS02440
gene id: 47304:DFR88_RS02440
uniprot id: A0A4D8S182
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

47304:DFR88 RS06355
gene id: 47304:DFR88_RS06355
uniprot id: A0A4D8S1M1
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

47304:DFR88 RS06185
gene id: 47304:DFR88_RS06185
uniprot id: A0A4D8S3I3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

47304:DFR88 RS09835
gene id: 47304:DFR88_RS09835
uniprot id: A0A4D8SGT5
names: Similarity
messages: Belongs to the acylphosphatase family.

47304:DFR88 RS10635
gene id: 47304:DFR88_RS10635
uniprot id: A0A4D8S0Q6
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS05545
gene id: 47304:DFR88_RS05545
uniprot id: A0A4D8S364
names: Similarity
messages: Belongs to the phosphohexose mutase family.

47304:DFR88 RS08590
gene id: 47304:DFR88_RS08590
uniprot id: A0A4D8S6T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

47304:DFR88 RS12005
gene id: 47304:DFR88_RS12005
uniprot id: A0A4D8S670
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS11840
gene id: 47304:DFR88_RS11840
uniprot id: A0A4D8S6C4
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS10705
gene id: 47304:DFR88_RS10705
uniprot id: A0A4D8S5K5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

47304:DFR88 RS11025
gene id: 47304:DFR88_RS11025
uniprot id: A0A4D8S5Q9
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

47304:DFR88 RS03880
gene id: 47304:DFR88_RS03880
uniprot id: A0A4D8S1Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

47304:DFR88 RS00445
gene id: 47304:DFR88_RS00445
uniprot id: A0A4D8SID4
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS07080
gene id: 47304:DFR88_RS07080
uniprot id: A0A4D8S6V5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

47304:DFR88 RS02945
gene id: 47304:DFR88_RS02945
uniprot id: A0A4D8RX80
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

47304:DFR88 RS06890
gene id: 47304:DFR88_RS06890
uniprot id: A0A4D8RWY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

47304:DFR88 RS03655
gene id: 47304:DFR88_RS03655
uniprot id: A0A4D8RXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

47304:DFR88 RS06755
gene id: 47304:DFR88_RS06755
uniprot id: A0A4D8RWV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

47304:DFR88 RS05375
gene id: 47304:DFR88_RS05375
uniprot id: A0A4D8S302
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

47304:DFR88 RS10930
gene id: 47304:DFR88_RS10930
uniprot id: A0A4D8S5V3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

47304:DFR88 RS05370
gene id: 47304:DFR88_RS05370
uniprot id: A0A4D8RS67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

47304:DFR88 RS11115
gene id: 47304:DFR88_RS11115
uniprot id: A0A4D8S0Y4
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

47304:DFR88 RS06680
gene id: 47304:DFR88_RS06680
uniprot id: A0A4D8RWU1
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

47304:DFR88 RS08920
gene id: 47304:DFR88_RS08920
uniprot id: A0A4D8S308
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

47304:DFR88 RS04005
gene id: 47304:DFR88_RS04005
uniprot id: A0A4D8RXR1
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS06140
gene id: 47304:DFR88_RS06140
uniprot id: A0A4D8S1G5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

47304:DFR88 RS09295
gene id: 47304:DFR88_RS09295
uniprot id: A0A4D8S0K0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

47304:DFR88 RS09300
gene id: 47304:DFR88_RS09300
uniprot id: A0A4D8SGH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

47304:DFR88 RS05680
gene id: 47304:DFR88_RS05680
uniprot id: A0A4D8RT03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

47304:DFR88 RS10185
gene id: 47304:DFR88_RS10185
uniprot id: A0A4D8S113
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

47304:DFR88 RS10125
gene id: 47304:DFR88_RS10125
uniprot id: A0A4D8SGY9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

47304:DFR88 RS09660
gene id: 47304:DFR88_RS09660
uniprot id: A0A4D8S0R2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

47304:DFR88 RS09805
gene id: 47304:DFR88_RS09805
uniprot id: A0A4D8S581
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

47304:DFR88 RS09090
gene id: 47304:DFR88_RS09090
uniprot id: A0A4D8S6S4
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS06145
gene id: 47304:DFR88_RS06145
uniprot id: A0A4D8RSJ6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

47304:DFR88 RS07825
gene id: 47304:DFR88_RS07825
uniprot id: A0A4D8S471
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

47304:DFR88 RS07330
gene id: 47304:DFR88_RS07330
uniprot id: A0A4D8RTS5
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS05635
gene id: 47304:DFR88_RS05635
uniprot id: A0A4D8S592
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS01375
gene id: 47304:DFR88_RS01375
uniprot id: A0A4D8RQV6
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS04435
gene id: 47304:DFR88_RS04435
uniprot id: A0A4D8RXY8
names: Similarity
messages: Belongs to the DNA photolyase family.

47304:DFR88 RS06850
gene id: 47304:DFR88_RS06850
uniprot id: A0A4D8S1X4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

47304:DFR88 RS10855
gene id: 47304:DFR88_RS10855
uniprot id: A0A4D8S6U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

47304:DFR88 RS10410
gene id: 47304:DFR88_RS10410
uniprot id: A0A4D8S7R6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

47304:DFR88 RS01180
gene id: 47304:DFR88_RS01180
uniprot id: A0A4D8SBP4
names: Similarity
messages: Belongs to the sterol desaturase family.

47304:DFR88 RS09590
gene id: 47304:DFR88_RS09590
uniprot id: A0A4D8RY69
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

47304:DFR88 RS08410
gene id: 47304:DFR88_RS08410
uniprot id: A0A4D8S6N9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS06195
gene id: 47304:DFR88_RS06195
uniprot id: A0A4D8S1I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

47304:DFR88 RS04875
gene id: 47304:DFR88_RS04875
uniprot id: A0A4D8RVY2
names: Similarity
messages: Belongs to the HerA family.

47304:DFR88 RS10155
gene id: 47304:DFR88_RS10155
uniprot id: A0A4D8S5E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

47304:DFR88 RS07590
gene id: 47304:DFR88_RS07590
uniprot id: A0A4D8S435
names: Similarity
messages: Belongs to the CinA family.

47304:DFR88 RS07995
gene id: 47304:DFR88_RS07995
uniprot id: A0A4D8S2Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

47304:DFR88 RS06930
gene id: 47304:DFR88_RS06930
uniprot id: A0A4D8S1Y1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

47304:DFR88 RS07540
gene id: 47304:DFR88_RS07540
uniprot id: A0A4D8RX94
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

47304:DFR88 RS09710
gene id: 47304:DFR88_RS09710
uniprot id: A0A4D8S7C1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

47304:DFR88 RS08620
gene id: 47304:DFR88_RS08620
uniprot id: A0A4D8S4M8
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

47304:DFR88 RS10145
gene id: 47304:DFR88_RS10145
uniprot id: A0A4D8S3P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

47304:DFR88 RS07270
gene id: 47304:DFR88_RS07270
uniprot id: A0A4D8RZA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

47304:DFR88 RS09520
gene id: 47304:DFR88_RS09520
uniprot id: A0A4D8RUU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

47304:DFR88 RS10165
gene id: 47304:DFR88_RS10165
uniprot id: A0A4D8SJ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

47304:DFR88 RS08425
gene id: 47304:DFR88_RS08425
uniprot id: A0A4D8S027
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

47304:DFR88 RS09930
gene id: 47304:DFR88_RS09930
uniprot id: A0A4D8S7G8
names: Similarity
messages: Belongs to the AAA ATPase family.

47304:DFR88 RS06535
gene id: 47304:DFR88_RS06535
uniprot id: A0A4D8S3P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

47304:DFR88 RS10050
gene id: 47304:DFR88_RS10050
uniprot id: A0A4D8S7J7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

47304:DFR88 RS11530
gene id: 47304:DFR88_RS11530
uniprot id: A0A4D8S1U7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

47304:DFR88 RS04095
gene id: 47304:DFR88_RS04095
uniprot id: A0A4D8RS83
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS03165
gene id: 47304:DFR88_RS03165
uniprot id: A0A4D8S1L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

47304:DFR88 RS05030
gene id: 47304:DFR88_RS05030
uniprot id: A0A4D8RSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

47304:DFR88 RS05625
gene id: 47304:DFR88_RS05625
uniprot id: A0A4D8RWA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

47304:DFR88 RS03705
gene id: 47304:DFR88_RS03705
uniprot id: A0A4D8RS17
names: Similarity
messages: Belongs to the UPF0282 family.

47304:DFR88 RS04290
gene id: 47304:DFR88_RS04290
uniprot id: A0A4D8RVR1
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

47304:DFR88 RS10260
gene id: 47304:DFR88_RS10260
uniprot id: A0A4D8RW27
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

47304:DFR88 RS08315
gene id: 47304:DFR88_RS08315
uniprot id: A0A4D8RZN5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

47304:DFR88 RS06905
gene id: 47304:DFR88_RS06905
uniprot id: A0A4D8S6M9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

47304:DFR88 RS06115
gene id: 47304:DFR88_RS06115
uniprot id: A0A4D8S5J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

47304:DFR88 RS07375
gene id: 47304:DFR88_RS07375
uniprot id: A0A4D8S447
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

47304:DFR88 RS03440
gene id: 47304:DFR88_RS03440
uniprot id: A0A4D8S2B8
names: Similarity
messages: Belongs to the AAA ATPase family.

47304:DFR88 RS08865
gene id: 47304:DFR88_RS08865
uniprot id: A0A4D8S1U2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS09745
gene id: 47304:DFR88_RS09745
uniprot id: A0A4D8RU92
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

47304:DFR88 RS08025
gene id: 47304:DFR88_RS08025
uniprot id: A0A4D8RVY9
names: Similarity
messages: Belongs to the UPF0147 family.

47304:DFR88 RS09530
gene id: 47304:DFR88_RS09530
uniprot id: A0A4D8S793
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

47304:DFR88 RS04815
gene id: 47304:DFR88_RS04815
uniprot id: A0A4D8RVX1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

47304:DFR88 RS00150
gene id: 47304:DFR88_RS00150
uniprot id: A0A4D8RVQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

47304:DFR88 RS10160
gene id: 47304:DFR88_RS10160
uniprot id: A0A4D8RV59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

47304:DFR88 RS06955
gene id: 47304:DFR88_RS06955
uniprot id: A0A4D8RWZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

47304:DFR88 RS09675
gene id: 47304:DFR88_RS09675
uniprot id: A0A4D8S1V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

47304:DFR88 RS09515
gene id: 47304:DFR88_RS09515
uniprot id: A0A4D8S532
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

47304:DFR88 RS08475
gene id: 47304:DFR88_RS08475
uniprot id: A0A4D8RZR2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

47304:DFR88 RS01005
gene id: 47304:DFR88_RS01005
uniprot id: A0A4D8RWB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS08485
gene id: 47304:DFR88_RS08485
uniprot id: A0A4D8S038
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

47304:DFR88 RS00870
gene id: 47304:DFR88_RS00870
uniprot id: A0A4D8RW30
names: Similarity
messages: Belongs to the BtpA family.

47304:DFR88 RS08605
gene id: 47304:DFR88_RS08605
uniprot id: A0A4D8SG27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

47304:DFR88 RS04025
gene id: 47304:DFR88_RS04025
uniprot id: A0A4D8S0B3
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS10065
gene id: 47304:DFR88_RS10065
uniprot id: A0A4D8SGX7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

47304:DFR88 RS06255
gene id: 47304:DFR88_RS06255
uniprot id: A0A4D8S1P0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

47304:DFR88 RS09320
gene id: 47304:DFR88_RS09320
uniprot id: A0A4D8S501
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

47304:DFR88 RS06990
gene id: 47304:DFR88_RS06990
uniprot id: A0A4D8RVW3
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

47304:DFR88 RS10085
gene id: 47304:DFR88_RS10085
uniprot id: A0A4D8S5D5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

47304:DFR88 RS03330
gene id: 47304:DFR88_RS03330
uniprot id: A0A4D8S298
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

47304:DFR88 RS06100
gene id: 47304:DFR88_RS06100
uniprot id: A0A4D8RT68
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

47304:DFR88 RS06360
gene id: 47304:DFR88_RS06360
uniprot id: A0A4D8RSR8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

47304:DFR88 RS07530
gene id: 47304:DFR88_RS07530
uniprot id: A0A4D8S426
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

47304:DFR88 RS09465
gene id: 47304:DFR88_RS09465
uniprot id: A0A4D8RUS9
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
messages: Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.

47304:DFR88 RS00035
gene id: 47304:DFR88_RS00035
uniprot id: A0A4D8RVN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

47304:DFR88 RS05825
gene id: 47304:DFR88_RS05825
uniprot id: A0A4D8S3B9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS10820
gene id: 47304:DFR88_RS10820
uniprot id: A0A4D8S410
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS07160
gene id: 47304:DFR88_RS07160
uniprot id: A0A4D8S404
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

47304:DFR88 RS07845
gene id: 47304:DFR88_RS07845
uniprot id: A0A4D8S6E5
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

47304:DFR88 RS03410
gene id: 47304:DFR88_RS03410
uniprot id: A0A4D8RRW9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

47304:DFR88 RS03415
gene id: 47304:DFR88_RS03415
uniprot id: A0A4D8RV78
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

47304:DFR88 RS01955
gene id: 47304:DFR88_RS01955
uniprot id: A0A4D8SC67
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

47304:DFR88 RS03375
gene id: 47304:DFR88_RS03375
uniprot id: A0A4D8RXE3
names: Subunit
messages: Homodimer.

47304:DFR88 RS00505
gene id: 47304:DFR88_RS00505
uniprot id: A0A4D8S029
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

47304:DFR88 RS07760
gene id: 47304:DFR88_RS07760
uniprot id: A0A4D8RTY7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

47304:DFR88 RS08985
gene id: 47304:DFR88_RS08985
uniprot id: A0A4D8S702
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

47304:DFR88 RS08880
gene id: 47304:DFR88_RS08880
uniprot id: A0A4D8S0B7
names: Similarity
messages: Belongs to the EPSP synthase family.

47304:DFR88 RS05290
gene id: 47304:DFR88_RS05290
uniprot id: A0A4D8RYD3
names: Similarity
messages: Belongs to the thioesterase PaaI family.

47304:DFR88 RS02335
gene id: 47304:DFR88_RS02335
uniprot id: A0A4D8RWZ2
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

47304:DFR88 RS03325
gene id: 47304:DFR88_RS03325
uniprot id: A0A4D8SCW6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

47304:DFR88 RS10135
gene id: 47304:DFR88_RS10135
uniprot id: A0A4D8S329
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

47304:DFR88 RS01480
gene id: 47304:DFR88_RS01480
uniprot id: A0A4D8S0P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

47304:DFR88 RS11930
gene id: 47304:DFR88_RS11930
uniprot id: A0A4D8S238
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS08200
gene id: 47304:DFR88_RS08200
uniprot id: A0A4D8RXJ7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

47304:DFR88 RS05855
gene id: 47304:DFR88_RS05855
uniprot id: A0A4D8RWE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

47304:DFR88 RS02230
gene id: 47304:DFR88_RS02230
uniprot id: A0A4D8S6I5
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS01065
gene id: 47304:DFR88_RS01065
uniprot id: A0A4D8RW74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

47304:DFR88 RS10270
gene id: 47304:DFR88_RS10270
uniprot id: A0A4D8RUI8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS02435
gene id: 47304:DFR88_RS02435
uniprot id: A0A4D8RQR8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

47304:DFR88 RS06650
gene id: 47304:DFR88_RS06650
uniprot id: A0A4D8S3S1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

47304:DFR88 RS08625
gene id: 47304:DFR88_RS08625
uniprot id: A0A4D8S319
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

47304:DFR88 RS08305
gene id: 47304:DFR88_RS08305
uniprot id: A0A4D8RXL3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

47304:DFR88 RS05670
gene id: 47304:DFR88_RS05670
uniprot id: A0A4D8RSB4
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

47304:DFR88 RS00640
gene id: 47304:DFR88_RS00640
uniprot id: A0A4D8SBF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS06690
gene id: 47304:DFR88_RS06690
uniprot id: A0A4D8RZ16
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

47304:DFR88 RS05610
gene id: 47304:DFR88_RS05610
uniprot id: A0A4D8RSA7
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

47304:DFR88 RS03720
gene id: 47304:DFR88_RS03720
uniprot id: A0A4D8RXK8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

47304:DFR88 RS07195
gene id: 47304:DFR88_RS07195
uniprot id: A0A4D8RZ85
names: Similarity
messages: Belongs to the SUI1 family.

47304:DFR88 RS01255
gene id: 47304:DFR88_RS01255
uniprot id: A0A4D8RQ72
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

47304:DFR88 RS03620
gene id: 47304:DFR88_RS03620
uniprot id: A0A4D8S2E0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS06530
gene id: 47304:DFR88_RS06530
uniprot id: A0A4D8SEW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

47304:DFR88 RS07440
gene id: 47304:DFR88_RS07440
uniprot id: A0A4D8S456
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

47304:DFR88 RS09680
gene id: 47304:DFR88_RS09680
uniprot id: A0A4D8S3H5
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

47304:DFR88 RS02800
gene id: 47304:DFR88_RS02800
uniprot id: A0A4D8S3U3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS01315
gene id: 47304:DFR88_RS01315
uniprot id: A0A4D8S0K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

47304:DFR88 RS07445
gene id: 47304:DFR88_RS07445
uniprot id: A0A4D8S2D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

47304:DFR88 RS01925
gene id: 47304:DFR88_RS01925
uniprot id: A0A4D8S0X9
names: Similarity
messages: Belongs to the HypD family.

47304:DFR88 RS07715
gene id: 47304:DFR88_RS07715
uniprot id: A0A4D8S6C8
names: Subcellular Location Annotation
messages: Cell membrane

47304:DFR88 RS03730
gene id: 47304:DFR88_RS03730
uniprot id: A0A4D8SD45
names: Similarity
messages: Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family.

47304:DFR88 RS06600
gene id: 47304:DFR88_RS06600
uniprot id: A0A4D8S1S9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

47304:DFR88 RS08180
gene id: 47304:DFR88_RS08180
uniprot id: A0A4D8RTI9
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

47304:DFR88 RS02850
gene id: 47304:DFR88_RS02850
uniprot id: A0A4D8RRN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

47304:DFR88 RS07225
gene id: 47304:DFR88_RS07225
uniprot id: A0A4D8S943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS05815
gene id: 47304:DFR88_RS05815
uniprot id: A0A4D8RYM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

47304:DFR88 RS08395
gene id: 47304:DFR88_RS08395
uniprot id: A0A4D8S4G9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

47304:DFR88 RS06550
gene id: 47304:DFR88_RS06550
uniprot id: A0A4D8S4Z8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

47304:DFR88 RS06200
gene id: 47304:DFR88_RS06200
uniprot id: A0A4D8RSL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS06445
gene id: 47304:DFR88_RS06445
uniprot id: A0A4D8RTC2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

47304:DFR88 RS08255
gene id: 47304:DFR88_RS08255
uniprot id: A0A4D8S6K5
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

47304:DFR88 RS11170
gene id: 47304:DFR88_RS11170
uniprot id: A0A4D8S0Z3
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

47304:DFR88 RS01070
gene id: 47304:DFR88_RS01070
uniprot id: A0A4D8SBM4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

47304:DFR88 RS09550
gene id: 47304:DFR88_RS09550
uniprot id: A0A4D8SGM1
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

47304:DFR88 RS03610
gene id: 47304:DFR88_RS03610
uniprot id: A0A4D8SD23
names: Similarity
messages: Belongs to the glutamine synthetase family.

47304:DFR88 RS06135
gene id: 47304:DFR88_RS06135
uniprot id: A0A4D8S3H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

47304:DFR88 RS04725
gene id: 47304:DFR88_RS04725
uniprot id: A0A4D8RY32
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

47304:DFR88 RS06640
gene id: 47304:DFR88_RS06640
uniprot id: A0A4D8RZ36
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

47304:DFR88 RS10460
gene id: 47304:DFR88_RS10460
uniprot id: A0A4D8RYL6
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

47304:DFR88 RS06615
gene id: 47304:DFR88_RS06615
uniprot id: A0A4D8RTF4
names: Similarity
messages: Belongs to the HTP reductase family.

47304:DFR88 RS08355
gene id: 47304:DFR88_RS08355
uniprot id: A0A4D8RXM4
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

47304:DFR88 RS06925
gene id: 47304:DFR88_RS06925
uniprot id: A0A4D8S509
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

47304:DFR88 RS08160
gene id: 47304:DFR88_RS08160
uniprot id: A0A4D8RZX7
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

47304:DFR88 RS06730
gene id: 47304:DFR88_RS06730
uniprot id: A0A4D8S3P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

47304:DFR88 RS01735
gene id: 47304:DFR88_RS01735
uniprot id: A0A4D8SC27
names: Function
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.

47304:DFR88 RS01170
gene id: 47304:DFR88_RS01170
uniprot id: A0A4D8RWE7
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS09200
gene id: 47304:DFR88_RS09200
uniprot id: A0A4D8RU02
names: Similarity
messages: Belongs to the UDPGP type 2 family.

47304:DFR88 RS03540
gene id: 47304:DFR88_RS03540
uniprot id: A0A4D8RXH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

47304:DFR88 RS02560
gene id: 47304:DFR88_RS02560
uniprot id: A0A4D8S1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

47304:DFR88 RS02575
gene id: 47304:DFR88_RS02575
uniprot id: A0A4D8S3Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

47304:DFR88 RS06765
gene id: 47304:DFR88_RS06765
uniprot id: A0A4D8RZ26
names: Subcellular Location Annotation
messages: Nucleus

47304:DFR88 RS10255
gene id: 47304:DFR88_RS10255
uniprot id: A0A4D8S5C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

47304:DFR88 RS10450
gene id: 47304:DFR88_RS10450
uniprot id: A0A4D8S5J9
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

47304:DFR88 RS08910
gene id: 47304:DFR88_RS08910
uniprot id: A0A4D8RUI6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

47304:DFR88 RS10005
gene id: 47304:DFR88_RS10005
uniprot id: A0A4D8RWN2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

47304:DFR88 RS04930
gene id: 47304:DFR88_RS04930
uniprot id: A0A4D8RVZ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

47304:DFR88 RS00840
gene id: 47304:DFR88_RS00840
uniprot id: A0A4D8SBH8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

47304:DFR88 RS04100
gene id: 47304:DFR88_RS04100
uniprot id: A0A4D8RVJ0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

47304:DFR88 RS08775
gene id: 47304:DFR88_RS08775
uniprot id: A0A4D8SG71
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

47304:DFR88 RS10325
gene id: 47304:DFR88_RS10325
uniprot id: A0A4D8S5H5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

47304:DFR88 RS05250
gene id: 47304:DFR88_RS05250
uniprot id: A0A4D8S314
names: Similarity
messages: Belongs to the citrate synthase family.

47304:DFR88 RS06170
gene id: 47304:DFR88_RS06170
uniprot id: A0A4D8RYT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS02095
gene id: 47304:DFR88_RS02095
uniprot id: A0A4D8RUK9
names: Similarity
messages: Belongs to the UPF0248 family.

47304:DFR88 RS11080
gene id: 47304:DFR88_RS11080
uniprot id: A0A4D8S5R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

47304:DFR88 RS07030
gene id: 47304:DFR88_RS07030
uniprot id: A0A4D8RX08
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

47304:DFR88 RS05820
gene id: 47304:DFR88_RS05820
uniprot id: A0A4D8SED9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS07185
gene id: 47304:DFR88_RS07185
uniprot id: A0A4D8RX41
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

47304:DFR88 RS09975
gene id: 47304:DFR88_RS09975
uniprot id: A0A4D8S7I0
names: Similarity
messages: Belongs to the GcvT family.

47304:DFR88 RS06190
gene id: 47304:DFR88_RS06190
uniprot id: A0A4D8RZN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

47304:DFR88 RS09250
gene id: 47304:DFR88_RS09250
uniprot id: A0A4D8RU15
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

47304:DFR88 RS05050
gene id: 47304:DFR88_RS05050
uniprot id: A0A4D8RY92
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 2 family.

47304:DFR88 RS06480
gene id: 47304:DFR88_RS06480
uniprot id: A0A4D8S3N5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

47304:DFR88 RS11945
gene id: 47304:DFR88_RS11945
uniprot id: A0A4D8S4L2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

47304:DFR88 RS07310
gene id: 47304:DFR88_RS07310
uniprot id: A0A4D8S6P4
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS06585
gene id: 47304:DFR88_RS06585
uniprot id: A0A4D8RZ22
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

47304:DFR88 RS08310
gene id: 47304:DFR88_RS08310
uniprot id: A0A4D8S6L8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

47304:DFR88 RS01365
gene id: 47304:DFR88_RS01365
uniprot id: A0A4D8RQ89
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

47304:DFR88 RS09595
gene id: 47304:DFR88_RS09595
uniprot id: A0A4D8S7A1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

47304:DFR88 RS07955
gene id: 47304:DFR88_RS07955
uniprot id: A0A4D8S6R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

47304:DFR88 RS05590
gene id: 47304:DFR88_RS05590
uniprot id: A0A4D8RYI0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

47304:DFR88 RS04940
gene id: 47304:DFR88_RS04940
uniprot id: A0A4D8RY72
names: Similarity
messages: Belongs to the UPF0237 family.

47304:DFR88 RS02785
gene id: 47304:DFR88_RS02785
uniprot id: A0A4D8S8S3
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

47304:DFR88 RS10340
gene id: 47304:DFR88_RS10340
uniprot id: A0A4D8RYJ6
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

47304:DFR88 RS11880
gene id: 47304:DFR88_RS11880
uniprot id: A0A4D8SI96
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

47304:DFR88 RS06595
gene id: 47304:DFR88_RS06595
uniprot id: A0A4D8S3R0
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

47304:DFR88 RS04410
gene id: 47304:DFR88_RS04410
uniprot id: A0A4D8RSD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS01860
gene id: 47304:DFR88_RS01860
uniprot id: A0A4D8SIG8
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

47304:DFR88 RS07150
gene id: 47304:DFR88_RS07150
uniprot id: A0A4D8RZE4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS06310
gene id: 47304:DFR88_RS06310
uniprot id: A0A4D8S2R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

47304:DFR88 RS03495
gene id: 47304:DFR88_RS03495
uniprot id: A0A4D8RXG8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

47304:DFR88 RS10920
gene id: 47304:DFR88_RS10920
uniprot id: A0A4D8S432
names: Similarity
messages: Belongs to the SfsA family.

47304:DFR88 RS05425
gene id: 47304:DFR88_RS05425
uniprot id: A0A4D8RS78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

47304:DFR88 RS03545
gene id: 47304:DFR88_RS03545
uniprot id: A0A4D8RXI0
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

47304:DFR88 RS06150
gene id: 47304:DFR88_RS06150
uniprot id: A0A4D8S3D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

47304:DFR88 RS10140
gene id: 47304:DFR88_RS10140
uniprot id: A0A4D8S5A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

47304:DFR88 RS02720
gene id: 47304:DFR88_RS02720
uniprot id: A0A4D8S1D8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

47304:DFR88 RS00805
gene id: 47304:DFR88_RS00805
uniprot id: A0A4D8RPZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

47304:DFR88 RS05580
gene id: 47304:DFR88_RS05580
uniprot id: A0A4D8S582
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

47304:DFR88 RS06220
gene id: 47304:DFR88_RS06220
uniprot id: A0A4D8S919
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

47304:DFR88 RS06590
gene id: 47304:DFR88_RS06590
uniprot id: A0A4D8SEY2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

47304:DFR88 RS08490
gene id: 47304:DFR88_RS08490
uniprot id: A0A4D8SG08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

47304:DFR88 RS03535
gene id: 47304:DFR88_RS03535
uniprot id: A0A4D8S466
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

47304:DFR88 RS08680
gene id: 47304:DFR88_RS08680
uniprot id: A0A4D8RTS2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

47304:DFR88 RS10150
gene id: 47304:DFR88_RS10150
uniprot id: A0A4D8RUG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

47304:DFR88 RS03115
gene id: 47304:DFR88_RS03115
uniprot id: A0A4D8SIL1
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

47304:DFR88 RS10785
gene id: 47304:DFR88_RS10785
uniprot id: A0A4D8SJ82
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

47304:DFR88 RS00620
gene id: 47304:DFR88_RS00620
uniprot id: A0A4D8RTS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47304:DFR88 RS07035
gene id: 47304:DFR88_RS07035
uniprot id: A0A4D8S619
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

47304:DFR88 RS06555
gene id: 47304:DFR88_RS06555
uniprot id: A0A4D8RSU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

47304:DFR88 RS03250
gene id: 47304:DFR88_RS03250
uniprot id: A0A4D8SCV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

47304:DFR88 RS09585
gene id: 47304:DFR88_RS09585
uniprot id: A0A4D8RUV2
names: Similarity
messages: Belongs to the CutA family.

47304:DFR88 RS09690
gene id: 47304:DFR88_RS09690
uniprot id: A0A4D8S563
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

47304:DFR88 RS09205
gene id: 47304:DFR88_RS09205
uniprot id: A0A4D8S4Y2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

47304:DFR88 RS06215
gene id: 47304:DFR88_RS06215
uniprot id: A0A4D8RWJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS02790
gene id: 47304:DFR88_RS02790
uniprot id: A0A4D8RRM8
names: Similarity
messages: Belongs to the HerA family.

47304:DFR88 RS07965
gene id: 47304:DFR88_RS07965
uniprot id: A0A4D8S6G4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

47304:DFR88 RS07050
gene id: 47304:DFR88_RS07050
uniprot id: A0A4D8SF91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

47304:DFR88 RS07495
gene id: 47304:DFR88_RS07495
uniprot id: A0A4D8RZR4
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

47304:DFR88 RS10080
gene id: 47304:DFR88_RS10080
uniprot id: A0A4D8RUF4
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

47304:DFR88 RS02890
gene id: 47304:DFR88_RS02890
uniprot id: A0A4D8SIJ8
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS08010
gene id: 47304:DFR88_RS08010
uniprot id: A0A4D8RU21
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

47304:DFR88 RS07575
gene id: 47304:DFR88_RS07575
uniprot id: A0A4D8S473
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

47304:DFR88 RS10180
gene id: 47304:DFR88_RS10180
uniprot id: A0A4D8S0I4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

47304:DFR88 RS07565
gene id: 47304:DFR88_RS07565
uniprot id: A0A4D8RZM8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

47304:DFR88 RS09235
gene id: 47304:DFR88_RS09235
uniprot id: A0A4D8SGG3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

47304:DFR88 RS09695
gene id: 47304:DFR88_RS09695
uniprot id: A0A4D8RUX4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

47304:DFR88 RS10490
gene id: 47304:DFR88_RS10490
uniprot id: A0A4D8S3V5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

47304:DFR88 RS09840
gene id: 47304:DFR88_RS09840
uniprot id: A0A4D8S557
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

47304:DFR88 RS09335
gene id: 47304:DFR88_RS09335
uniprot id: A0A4D8S760
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

47304:DFR88 RS09850
gene id: 47304:DFR88_RS09850
uniprot id: A0A4D8RUB2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS05575
gene id: 47304:DFR88_RS05575
uniprot id: A0A4D8RW95
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

47304:DFR88 RS05615
gene id: 47304:DFR88_RS05615
uniprot id: A0A4D8S347
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

47304:DFR88 RS03305
gene id: 47304:DFR88_RS03305
uniprot id: A0A4D8S424
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

47304:DFR88 RS07070
gene id: 47304:DFR88_RS07070
uniprot id: A0A4D8S3U4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

47304:DFR88 RS08500
gene id: 47304:DFR88_RS08500
uniprot id: A0A4D8S300
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

47304:DFR88 RS09970
gene id: 47304:DFR88_RS09970
uniprot id: A0A4D8RYD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

47304:DFR88 RS11210
gene id: 47304:DFR88_RS11210
uniprot id: A0A4D8RVN9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

47304:DFR88 RS07260
gene id: 47304:DFR88_RS07260
uniprot id: A0A4D8RX59
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

47304:DFR88 RS07805
gene id: 47304:DFR88_RS07805
uniprot id: A0A4D8S4A9
names: Similarity
messages: Belongs to the PGI/PMI family.

47304:DFR88 RS04090
gene id: 47304:DFR88_RS04090
uniprot id: A0A4D8S242
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS05765
gene id: 47304:DFR88_RS05765
uniprot id: A0A4D8S3A9
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

47304:DFR88 RS07950
gene id: 47304:DFR88_RS07950
uniprot id: A0A4D8RU12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

47304:DFR88 RS01345
gene id: 47304:DFR88_RS01345
uniprot id: A0A4D8SBU7
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS07535
gene id: 47304:DFR88_RS07535
uniprot id: A0A4D8RTV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

47304:DFR88 RS03640
gene id: 47304:DFR88_RS03640
uniprot id: A0A4D8RS08
names: Similarity
messages: Belongs to the RuvB family.

47304:DFR88 RS06230
gene id: 47304:DFR88_RS06230
uniprot id: A0A4D8RYU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

47304:DFR88 RS06345
gene id: 47304:DFR88_RS06345
uniprot id: A0A4D8SES4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

47304:DFR88 RS04630
gene id: 47304:DFR88_RS04630
uniprot id: A0A4D8RRS7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

47304:DFR88 RS04155
gene id: 47304:DFR88_RS04155
uniprot id: A0A4D8RS94
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

47304:DFR88 RS11075
gene id: 47304:DFR88_RS11075
uniprot id: A0A4D8S737
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS10195
gene id: 47304:DFR88_RS10195
uniprot id: A0A4D8S5B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

47304:DFR88 RS08845
gene id: 47304:DFR88_RS08845
uniprot id: A0A4D8RTU9
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS06370
gene id: 47304:DFR88_RS06370
uniprot id: A0A4D8RTB3
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

47304:DFR88 RS00875
gene id: 47304:DFR88_RS00875
uniprot id: A0A4D8RTX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

47304:DFR88 RS05260
gene id: 47304:DFR88_RS05260
uniprot id: A0A4D8RS46
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

47304:DFR88 RS10765
gene id: 47304:DFR88_RS10765
uniprot id: A0A4D8S400
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

47304:DFR88 RS05335
gene id: 47304:DFR88_RS05335
uniprot id: A0A4D8RYE8
names: Similarity
messages: Belongs to the thioesterase PaaI family.

47304:DFR88 RS08125
gene id: 47304:DFR88_RS08125
uniprot id: A0A4D8RTI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

47304:DFR88 RS11280
gene id: 47304:DFR88_RS11280
uniprot id: A0A4D8S888
names: Similarity
messages: Belongs to the pyruvate kinase family.

47304:DFR88 RS08860
gene id: 47304:DFR88_RS08860
uniprot id: A0A4D8RXW0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS10310
gene id: 47304:DFR88_RS10310
uniprot id: A0A4D8S5D6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS00980
gene id: 47304:DFR88_RS00980
uniprot id: A0A4D8S8P3
names: Similarity
messages: Belongs to the class-I fumarase family.

47304:DFR88 RS07140
gene id: 47304:DFR88_RS07140
uniprot id: A0A4D8RX31
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

47304:DFR88 RS05585
gene id: 47304:DFR88_RS05585
uniprot id: A0A4D8RYJ2
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

47304:DFR88 RS06160
gene id: 47304:DFR88_RS06160
uniprot id: A0A4D8RWI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

47304:DFR88 RS07130
gene id: 47304:DFR88_RS07130
uniprot id: A0A4D8RTP3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

47304:DFR88 RS07460
gene id: 47304:DFR88_RS07460
uniprot id: A0A4D8S415
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

47304:DFR88 RS06715
gene id: 47304:DFR88_RS06715
uniprot id: A0A4D8S1U6
names: Similarity
messages: Belongs to the UPF0215 family.

47304:DFR88 RS09870
gene id: 47304:DFR88_RS09870
uniprot id: A0A4D8S7F6
names: Similarity
messages: Belongs to the TrpC family.

47304:DFR88 RS08745
gene id: 47304:DFR88_RS08745
uniprot id: A0A4D8S4N6
names: Similarity
messages: Belongs to the complex I subunit 3 family.

47304:DFR88 RS07475
gene id: 47304:DFR88_RS07475
uniprot id: A0A4D8S687
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

47304:DFR88 RS01360
gene id: 47304:DFR88_RS01360
uniprot id: A0A4D8RYV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS02010
gene id: 47304:DFR88_RS02010
uniprot id: A0A4D8S1U3
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

47304:DFR88 RS08385
gene id: 47304:DFR88_RS08385
uniprot id: A0A4D8S2Y4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47304:DFR88 RS08840
gene id: 47304:DFR88_RS08840
uniprot id: A0A4D8S352
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS04015
gene id: 47304:DFR88_RS04015
uniprot id: A0A4D8SD98
names: Subcellular Location Annotation
messages: Membrane

47304:DFR88 RS06885
gene id: 47304:DFR88_RS06885
uniprot id: A0A4D8RTJ9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

47304:DFR88 RS08815
gene id: 47304:DFR88_RS08815
uniprot id: A0A4D8RZX2
names: Similarity
messages: Belongs to the glutamate synthase family.

47304:DFR88 RS06570
gene id: 47304:DFR88_RS06570
uniprot id: A0A4D8RWR7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

47304:DFR88 RS00515
gene id: 47304:DFR88_RS00515
uniprot id: A0A4D8RTQ4
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS09980
gene id: 47304:DFR88_RS09980
uniprot id: A0A4D8S0F9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

47304:DFR88 RS08640
gene id: 47304:DFR88_RS08640
uniprot id: A0A4D8RUD3
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

47304:DFR88 RS00800
gene id: 47304:DFR88_RS00800
uniprot id: A0A4D8RYI8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

47304:DFR88 RS08885
gene id: 47304:DFR88_RS08885
uniprot id: A0A4D8SG94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

47304:DFR88 RS08015
gene id: 47304:DFR88_RS08015
uniprot id: A0A4D8RXG9
names: Similarity
messages: Belongs to the thymidylate kinase family.

47304:DFR88 RS06455
gene id: 47304:DFR88_RS06455
uniprot id: A0A4D8S5S5
names: Similarity
messages: Belongs to the HerA family.

47304:DFR88 RS06235
gene id: 47304:DFR88_RS06235
uniprot id: A0A4D8RYU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

47304:DFR88 RS06330
gene id: 47304:DFR88_RS06330
uniprot id: A0A4D8S5Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

47304:DFR88 RS03050
gene id: 47304:DFR88_RS03050
uniprot id: A0A4D8RV17
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

47304:DFR88 RS09845
gene id: 47304:DFR88_RS09845
uniprot id: A0A4D8S3K4
names: Function
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

47304:DFR88 RS05265
gene id: 47304:DFR88_RS05265
uniprot id: A0A4D8S2X4
names: Similarity
messages: Belongs to the PrpD family.

47304:DFR88 RS08565
gene id: 47304:DFR88_RS08565
uniprot id: A0A4D8S310
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

47304:DFR88 RS07470
gene id: 47304:DFR88_RS07470
uniprot id: A0A4D8RX84
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

47304:DFR88 RS07480
gene id: 47304:DFR88_RS07480
uniprot id: A0A4D8RZC1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

47304:DFR88 RS05295
gene id: 47304:DFR88_RS05295
uniprot id: A0A4D8SDZ3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

47304:DFR88 RS06365
gene id: 47304:DFR88_RS06365
uniprot id: A0A4D8S3I0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

47304:DFR88 RS10580
gene id: 47304:DFR88_RS10580
uniprot id: A0A4D8S7V1
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.