453591:IGNI RS05645
gene id: 453591:IGNI_RS05645
uniprot id: A8ABH2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Heterodimer composed of an alpha and a beta subunit.

453591:IGNI RS00555
gene id: 453591:IGNI_RS00555
uniprot id: A8A8N6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

453591:IGNI RS02075
gene id: 453591:IGNI_RS02075
uniprot id: A8A9I2
names: Similarity
messages: Belongs to the CutA family.

453591:IGNI RS01945
gene id: 453591:IGNI_RS01945
uniprot id: A8A9F7
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

453591:IGNI RS04105
gene id: 453591:IGNI_RS04105
uniprot id: A8AAM6
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

453591:IGNI RS02945
gene id: 453591:IGNI_RS02945
uniprot id: A8A9Z6
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

453591:IGNI RS04620
gene id: 453591:IGNI_RS04620
uniprot id: A8AAX5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

453591:IGNI RS04540
gene id: 453591:IGNI_RS04540
uniprot id: A8AAW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

453591:IGNI RS03320
gene id: 453591:IGNI_RS03320
uniprot id: A8AA67
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

453591:IGNI RS04865
gene id: 453591:IGNI_RS04865
uniprot id: A8AB24
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

453591:IGNI RS03635
gene id: 453591:IGNI_RS03635
uniprot id: A8AAD2
names: Similarity
messages: Belongs to the DtxR/MntR family.

453591:IGNI RS01260
gene id: 453591:IGNI_RS01260
uniprot id: A8A925
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

453591:IGNI RS04740
gene id: 453591:IGNI_RS04740
uniprot id: A8AAZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

453591:IGNI RS05710
gene id: 453591:IGNI_RS05710
uniprot id: A8ABI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

453591:IGNI RS01640
gene id: 453591:IGNI_RS01640
uniprot id: A8A998
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

453591:IGNI RS03230
gene id: 453591:IGNI_RS03230
uniprot id: A8AA51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

453591:IGNI RS04940
gene id: 453591:IGNI_RS04940
uniprot id: A8AB39
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

453591:IGNI RS04100
gene id: 453591:IGNI_RS04100
uniprot id: A8AAM5
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

453591:IGNI RS07350
gene id: 453591:IGNI_RS07350
uniprot id: A8ACE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

453591:IGNI RS06530
gene id: 453591:IGNI_RS06530
uniprot id: A8ABZ3
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS03525
gene id: 453591:IGNI_RS03525
uniprot id: A8AAA9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

453591:IGNI RS03000
gene id: 453591:IGNI_RS03000
uniprot id: A8AA07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

453591:IGNI RS04990
gene id: 453591:IGNI_RS04990
uniprot id: A8AB48
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

453591:IGNI RS06925
gene id: 453591:IGNI_RS06925
uniprot id: A8AC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

453591:IGNI RS03945
gene id: 453591:IGNI_RS03945
uniprot id: A8AAJ5
names: Similarity
messages: Belongs to the eIF-2-alpha family.

453591:IGNI RS03895
gene id: 453591:IGNI_RS03895
uniprot id: A8AAI4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

453591:IGNI RS05100
gene id: 453591:IGNI_RS05100
uniprot id: A8AB68
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

453591:IGNI RS06585
gene id: 453591:IGNI_RS06585
uniprot id: A8AC04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

453591:IGNI RS00965
gene id: 453591:IGNI_RS00965
uniprot id: A8A8W6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

453591:IGNI RS06555
gene id: 453591:IGNI_RS06555
uniprot id: A8ABZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

453591:IGNI RS06975
gene id: 453591:IGNI_RS06975
uniprot id: A8AC73
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

453591:IGNI RS02875
gene id: 453591:IGNI_RS02875
uniprot id: A8A9Y4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS04495
gene id: 453591:IGNI_RS04495
uniprot id: A8AAV1
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

453591:IGNI RS07775
gene id: 453591:IGNI_RS07775
uniprot id: A8AAU4
names: Similarity
messages: Belongs to the Nth/MutY family.

453591:IGNI RS06065
gene id: 453591:IGNI_RS06065
uniprot id: A8ABQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

453591:IGNI RS07100
gene id: 453591:IGNI_RS07100
uniprot id: A8AC95
names: Similarity
messages: Belongs to the arginase family.

453591:IGNI RS02110
gene id: 453591:IGNI_RS02110
uniprot id: A8A9I9
names: Similarity
messages: Belongs to the glutamate synthase family.

453591:IGNI RS04385
gene id: 453591:IGNI_RS04385
uniprot id: A8AAS9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

453591:IGNI RS02640
gene id: 453591:IGNI_RS02640
uniprot id: A8A9U2
names: Similarity
messages: Belongs to the UPF0282 family.

453591:IGNI RS05780
gene id: 453591:IGNI_RS05780
uniprot id: A8ABJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

453591:IGNI RS02930
gene id: 453591:IGNI_RS02930
uniprot id: A8A9Z3
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

453591:IGNI RS00935
gene id: 453591:IGNI_RS00935
uniprot id: A8A8W0
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

453591:IGNI RS04095
gene id: 453591:IGNI_RS04095
uniprot id: A8AAM4
names: Function
messages: Probably involved in the biogenesis of the ribosome.

453591:IGNI RS07095
gene id: 453591:IGNI_RS07095
uniprot id: A8AC94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

453591:IGNI RS04715
gene id: 453591:IGNI_RS04715
uniprot id: A8AAZ4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

453591:IGNI RS00455
gene id: 453591:IGNI_RS00455
uniprot id: A8A8L6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

453591:IGNI RS05555
gene id: 453591:IGNI_RS05555
uniprot id: A8ABF5
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

453591:IGNI RS01040
gene id: 453591:IGNI_RS01040
uniprot id: A8A8Y1
names: Similarity
messages: Belongs to the aspartokinase family.

453591:IGNI RS05805
gene id: 453591:IGNI_RS05805
uniprot id: A8ABK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

453591:IGNI RS06695
gene id: 453591:IGNI_RS06695
uniprot id: A8AC23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

453591:IGNI RS07370
gene id: 453591:IGNI_RS07370
uniprot id: A8ACE3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

453591:IGNI RS05340
gene id: 453591:IGNI_RS05340
uniprot id: A8ABB4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

453591:IGNI RS02350
gene id: 453591:IGNI_RS02350
uniprot id: A8A9N4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

453591:IGNI RS05925
gene id: 453591:IGNI_RS05925
uniprot id: A8ABM7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

453591:IGNI RS01770
gene id: 453591:IGNI_RS01770
uniprot id: A8A9C3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

453591:IGNI RS05450
gene id: 453591:IGNI_RS05450
uniprot id: A8ABD5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

453591:IGNI RS06950
gene id: 453591:IGNI_RS06950
uniprot id: A8AC69
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

453591:IGNI RS00240
gene id: 453591:IGNI_RS00240
uniprot id: A8A8H5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

453591:IGNI RS05560
gene id: 453591:IGNI_RS05560
uniprot id: A8ABF6
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

453591:IGNI RS07320
gene id: 453591:IGNI_RS07320
uniprot id: A8ACD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

453591:IGNI RS06300
gene id: 453591:IGNI_RS06300
uniprot id: A8ABU6
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS00230
gene id: 453591:IGNI_RS00230
uniprot id: A8A8H3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

453591:IGNI RS00945
gene id: 453591:IGNI_RS00945
uniprot id: A8A8W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

453591:IGNI RS07120
gene id: 453591:IGNI_RS07120
uniprot id: A8AC98
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

453591:IGNI RS00305
gene id: 453591:IGNI_RS00305
uniprot id: A8A8I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

453591:IGNI RS00570
gene id: 453591:IGNI_RS00570
uniprot id: A8A8N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

453591:IGNI RS04515
gene id: 453591:IGNI_RS04515
uniprot id: A8AAV5
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS00340
gene id: 453591:IGNI_RS00340
uniprot id: A8A8J4
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

453591:IGNI RS03575
gene id: 453591:IGNI_RS03575
uniprot id: A8AAC0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

453591:IGNI RS03985
gene id: 453591:IGNI_RS03985
uniprot id: A8AAK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

453591:IGNI RS04390
gene id: 453591:IGNI_RS04390
uniprot id: A8AAT0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

453591:IGNI RS06480
gene id: 453591:IGNI_RS06480
uniprot id: A8ABY3
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

453591:IGNI RS00170
gene id: 453591:IGNI_RS00170
uniprot id: A8A8G2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

453591:IGNI RS03210
gene id: 453591:IGNI_RS03210
uniprot id: A8AA47
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

453591:IGNI RS02680
gene id: 453591:IGNI_RS02680
uniprot id: A8A9U9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

453591:IGNI RS05950
gene id: 453591:IGNI_RS05950
uniprot id: A8ABN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

453591:IGNI RS00955
gene id: 453591:IGNI_RS00955
uniprot id: A8A8W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS02775
gene id: 453591:IGNI_RS02775
uniprot id: A8A9W6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS03860
gene id: 453591:IGNI_RS03860
uniprot id: A8AAH7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

453591:IGNI RS04355
gene id: 453591:IGNI_RS04355
uniprot id: A8AAS3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

453591:IGNI RS03415
gene id: 453591:IGNI_RS03415
uniprot id: A8AA87
names: Similarity
messages: Belongs to the diphthine synthase family.

453591:IGNI RS00310
gene id: 453591:IGNI_RS00310
uniprot id: A8A8I9
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

453591:IGNI RS00960
gene id: 453591:IGNI_RS00960
uniprot id: A8A8W5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

453591:IGNI RS05590
gene id: 453591:IGNI_RS05590
uniprot id: A8ABG2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

453591:IGNI RS03905
gene id: 453591:IGNI_RS03905
uniprot id: A8AAI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

453591:IGNI RS04440
gene id: 453591:IGNI_RS04440
uniprot id: A8AAU0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS05205
gene id: 453591:IGNI_RS05205
uniprot id: A8AB88
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS07455
gene id: 453591:IGNI_RS07455
uniprot id: A8ACF9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS07260
gene id: 453591:IGNI_RS07260
uniprot id: A8ACC3
names: Subunit
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

453591:IGNI RS01095
gene id: 453591:IGNI_RS01095
uniprot id: A8A8Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

453591:IGNI RS03580
gene id: 453591:IGNI_RS03580
uniprot id: A8AAC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

453591:IGNI RS00235
gene id: 453591:IGNI_RS00235
uniprot id: A8A8H4
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

453591:IGNI RS02150
gene id: 453591:IGNI_RS02150
uniprot id: A8A9J6
names: Similarity
messages: Belongs to the archaeal-type GPI family.

453591:IGNI RS01400
gene id: 453591:IGNI_RS01400
uniprot id: A8A953
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

453591:IGNI RS06315
gene id: 453591:IGNI_RS06315
uniprot id: A8ABV0
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

453591:IGNI RS00165
gene id: 453591:IGNI_RS00165
uniprot id: A8A8G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

453591:IGNI RS03610
gene id: 453591:IGNI_RS03610
uniprot id: A8AAC7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

453591:IGNI RS07280
gene id: 453591:IGNI_RS07280
uniprot id: A8ACC7
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

453591:IGNI RS07355
gene id: 453591:IGNI_RS07355
uniprot id: A8ACE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

453591:IGNI RS05135
gene id: 453591:IGNI_RS05135
uniprot id: A8AB75
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

453591:IGNI RS06590
gene id: 453591:IGNI_RS06590
uniprot id: A8AC05
names: Similarity
messages: Belongs to the SUI1 family.

453591:IGNI RS00055
gene id: 453591:IGNI_RS00055
uniprot id: A8A8D9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

453591:IGNI RS05405
gene id: 453591:IGNI_RS05405
uniprot id: A8ABC6
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

453591:IGNI RS06290
gene id: 453591:IGNI_RS06290
uniprot id: A8ABU4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

453591:IGNI RS03555
gene id: 453591:IGNI_RS03555
uniprot id: A8AAB6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

453591:IGNI RS04405
gene id: 453591:IGNI_RS04405
uniprot id: A8AAT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

453591:IGNI RS01880
gene id: 453591:IGNI_RS01880
uniprot id: A8A9E4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

453591:IGNI RS04285
gene id: 453591:IGNI_RS04285
uniprot id: A8AAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

453591:IGNI RS01755
gene id: 453591:IGNI_RS01755
uniprot id: A8A9B9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

453591:IGNI RS05725
gene id: 453591:IGNI_RS05725
uniprot id: A8ABI8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

453591:IGNI RS02155
gene id: 453591:IGNI_RS02155
uniprot id: A8A9J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

453591:IGNI RS02295
gene id: 453591:IGNI_RS02295
uniprot id: A8A9M3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

453591:IGNI RS02480
gene id: 453591:IGNI_RS02480
uniprot id: A8A9R0
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS00370
gene id: 453591:IGNI_RS00370
uniprot id: A8A8J9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

453591:IGNI RS02805
gene id: 453591:IGNI_RS02805
uniprot id: A8A9X2
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

453591:IGNI RS00795
gene id: 453591:IGNI_RS00795
uniprot id: A8A8T5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

453591:IGNI RS06685
gene id: 453591:IGNI_RS06685
uniprot id: A8AC21
names: Similarity
messages: Belongs to the MCM family.

453591:IGNI RS06905
gene id: 453591:IGNI_RS06905
uniprot id: A8AC61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

453591:IGNI RS02380
gene id: 453591:IGNI_RS02380
uniprot id: A8A9P0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

453591:IGNI RS03120
gene id: 453591:IGNI_RS03120
uniprot id: A8AA30
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

453591:IGNI RS04945
gene id: 453591:IGNI_RS04945
uniprot id: A8AB40
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS01375
gene id: 453591:IGNI_RS01375
uniprot id: A8A948
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

453591:IGNI RS00015
gene id: 453591:IGNI_RS00015
uniprot id: A8A8D3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

453591:IGNI RS01010
gene id: 453591:IGNI_RS01010
uniprot id: A8A8X5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

453591:IGNI RS03060
gene id: 453591:IGNI_RS03060
uniprot id: A8AA18
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

453591:IGNI RS02140
gene id: 453591:IGNI_RS02140
uniprot id: A8A9J4
names: Similarity
messages: Belongs to the HypD family.

453591:IGNI RS05015
gene id: 453591:IGNI_RS05015
uniprot id: A8AB53
names: Similarity
messages: Belongs to the PstS family.

453591:IGNI RS05145
gene id: 453591:IGNI_RS05145
uniprot id: A8AB77
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

453591:IGNI RS04980
gene id: 453591:IGNI_RS04980
uniprot id: A8AB46
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

453591:IGNI RS05150
gene id: 453591:IGNI_RS05150
uniprot id: A8AB78
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

453591:IGNI RS04410
gene id: 453591:IGNI_RS04410
uniprot id: A8AAT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

453591:IGNI RS05295
gene id: 453591:IGNI_RS05295
uniprot id: A8ABA5
names: Similarity
messages: Belongs to the glutaredoxin family.

453591:IGNI RS05355
gene id: 453591:IGNI_RS05355
uniprot id: A8ABB6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS06605
gene id: 453591:IGNI_RS06605
uniprot id: A8AC08
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

453591:IGNI RS00220
gene id: 453591:IGNI_RS00220
uniprot id: A8A8H1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

453591:IGNI RS02750
gene id: 453591:IGNI_RS02750
uniprot id: A8A9W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

453591:IGNI RS04735
gene id: 453591:IGNI_RS04735
uniprot id: A8AAZ8
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

453591:IGNI RS03690
gene id: 453591:IGNI_RS03690
uniprot id: A8AAE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

453591:IGNI RS01600
gene id: 453591:IGNI_RS01600
uniprot id: A8A990
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

453591:IGNI RS02040
gene id: 453591:IGNI_RS02040
uniprot id: A8A9H6
names: Similarity
messages: Belongs to the peptidase C56 family.

453591:IGNI RS00975
gene id: 453591:IGNI_RS00975
uniprot id: A8A8W8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

453591:IGNI RS04955
gene id: 453591:IGNI_RS04955
uniprot id: A8AB42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

453591:IGNI RS06955
gene id: 453591:IGNI_RS06955
uniprot id: A8AC70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

453591:IGNI RS00950
gene id: 453591:IGNI_RS00950
uniprot id: A8A8W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

453591:IGNI RS06700
gene id: 453591:IGNI_RS06700
uniprot id: A8AC24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

453591:IGNI RS04185
gene id: 453591:IGNI_RS04185
uniprot id: A8AAP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

453591:IGNI RS06485
gene id: 453591:IGNI_RS06485
uniprot id: A8ABY4
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

453591:IGNI RS02955
gene id: 453591:IGNI_RS02955
uniprot id: A8A9Z8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

453591:IGNI RS03205
gene id: 453591:IGNI_RS03205
uniprot id: A8AA46
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

453591:IGNI RS02030
gene id: 453591:IGNI_RS02030
uniprot id: A8A9H4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

453591:IGNI RS04765
gene id: 453591:IGNI_RS04765
uniprot id: A8AB04
names: Similarity
messages: Belongs to the TrpF family.

453591:IGNI RS04060
gene id: 453591:IGNI_RS04060
uniprot id: A8AAL8
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

453591:IGNI RS03080
gene id: 453591:IGNI_RS03080
uniprot id: A8AA22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

453591:IGNI RS01470
gene id: 453591:IGNI_RS01470
uniprot id: A8A966
names: Similarity
messages: Belongs to the PDCD5 family.

453591:IGNI RS04845
gene id: 453591:IGNI_RS04845
uniprot id: A8AB20
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

453591:IGNI RS01980
gene id: 453591:IGNI_RS01980
uniprot id: A8A9G4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

453591:IGNI RS03940
gene id: 453591:IGNI_RS03940
uniprot id: A8AAJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

453591:IGNI RS04140
gene id: 453591:IGNI_RS04140
uniprot id: A8AAN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

453591:IGNI RS04360
gene id: 453591:IGNI_RS04360
uniprot id: A8AAS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

453591:IGNI RS00080
gene id: 453591:IGNI_RS00080
uniprot id: A8A8E4
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

453591:IGNI RS06070
gene id: 453591:IGNI_RS06070
uniprot id: A8ABQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

453591:IGNI RS05605
gene id: 453591:IGNI_RS05605
uniprot id: A8ABG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

453591:IGNI RS05040
gene id: 453591:IGNI_RS05040
uniprot id: A8AB57
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

453591:IGNI RS01290
gene id: 453591:IGNI_RS01290
uniprot id: A8A931
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS04875
gene id: 453591:IGNI_RS04875
uniprot id: A8AB26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

453591:IGNI RS07880
gene id: 453591:IGNI_RS07880
uniprot id: A8AAA8
names: Similarity
messages: Belongs to the class-I fumarase family.

453591:IGNI RS04535
gene id: 453591:IGNI_RS04535
uniprot id: A8AAV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

453591:IGNI RS06205
gene id: 453591:IGNI_RS06205
uniprot id: A8ABS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

453591:IGNI RS05235
gene id: 453591:IGNI_RS05235
uniprot id: A8AB94
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

453591:IGNI RS01270
gene id: 453591:IGNI_RS01270
uniprot id: A8A927
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

453591:IGNI RS05610
gene id: 453591:IGNI_RS05610
uniprot id: A8ABG6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS00915
gene id: 453591:IGNI_RS00915
uniprot id: A8A8V6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

453591:IGNI RS03540
gene id: 453591:IGNI_RS03540
uniprot id: A8AAB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

453591:IGNI RS02820
gene id: 453591:IGNI_RS02820
uniprot id: A8A9X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

453591:IGNI RS02340
gene id: 453591:IGNI_RS02340
uniprot id: A8A9N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

453591:IGNI RS01275
gene id: 453591:IGNI_RS01275
uniprot id: A8A928
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

453591:IGNI RS06650
gene id: 453591:IGNI_RS06650
uniprot id: A8AC17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

453591:IGNI RS03605
gene id: 453591:IGNI_RS03605
uniprot id: A8AAC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS00515
gene id: 453591:IGNI_RS00515
uniprot id: A8A8M8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

453591:IGNI RS03195
gene id: 453591:IGNI_RS03195
uniprot id: A8AA44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

453591:IGNI RS06060
gene id: 453591:IGNI_RS06060
uniprot id: A8ABQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

453591:IGNI RS02165
gene id: 453591:IGNI_RS02165
uniprot id: A8A9J9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

453591:IGNI RS05885
gene id: 453591:IGNI_RS05885
uniprot id: A8ABL9
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS00225
gene id: 453591:IGNI_RS00225
uniprot id: A8A8H2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

453591:IGNI RS04455
gene id: 453591:IGNI_RS04455
uniprot id: A8AAU3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

453591:IGNI RS00870
gene id: 453591:IGNI_RS00870
uniprot id: A8A8U9
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

453591:IGNI RS00985
gene id: 453591:IGNI_RS00985
uniprot id: A8A8X0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

453591:IGNI RS01675
gene id: 453591:IGNI_RS01675
uniprot id: A8A9A5
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

453591:IGNI RS05620
gene id: 453591:IGNI_RS05620
uniprot id: A8ABG8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

453591:IGNI RS00940
gene id: 453591:IGNI_RS00940
uniprot id: A8A8W1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

453591:IGNI RS05520
gene id: 453591:IGNI_RS05520
uniprot id: A8ABE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

453591:IGNI RS01725
gene id: 453591:IGNI_RS01725
uniprot id: A8A9B3
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

453591:IGNI RS06575
gene id: 453591:IGNI_RS06575
uniprot id: A8AC02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

453591:IGNI RS05995
gene id: 453591:IGNI_RS05995
uniprot id: A8ABP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

453591:IGNI RS03140
gene id: 453591:IGNI_RS03140
uniprot id: A8AA33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

453591:IGNI RS01570
gene id: 453591:IGNI_RS01570
uniprot id: A8A984
names: Similarity
messages: Belongs to the UPF0237 family.

453591:IGNI RS02355
gene id: 453591:IGNI_RS02355
uniprot id: A8A9N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

453591:IGNI RS07335
gene id: 453591:IGNI_RS07335
uniprot id: A8ACD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS02285
gene id: 453591:IGNI_RS02285
uniprot id: A8A9M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

453591:IGNI RS00120
gene id: 453591:IGNI_RS00120
uniprot id: A8A8F2
names: Similarity
messages: Belongs to the UPF0047 family.

453591:IGNI RS02665
gene id: 453591:IGNI_RS02665
uniprot id: A8A9U6
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

453591:IGNI RS01560
gene id: 453591:IGNI_RS01560
uniprot id: A8A982
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

453591:IGNI RS06500
gene id: 453591:IGNI_RS06500
uniprot id: A8ABY7
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

453591:IGNI RS02420
gene id: 453591:IGNI_RS02420
uniprot id: A8A9P8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

453591:IGNI RS01910
gene id: 453591:IGNI_RS01910
uniprot id: A8A9F0
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

453591:IGNI RS01750
gene id: 453591:IGNI_RS01750
uniprot id: A8A9B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

453591:IGNI RS06170
gene id: 453591:IGNI_RS06170
uniprot id: A8ABS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

453591:IGNI RS02915
gene id: 453591:IGNI_RS02915
uniprot id: A8A9Z0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS00785
gene id: 453591:IGNI_RS00785
uniprot id: A8A8T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

453591:IGNI RS05155
gene id: 453591:IGNI_RS05155
uniprot id: A8AB79
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS05060
gene id: 453591:IGNI_RS05060
uniprot id: A8AB61
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

453591:IGNI RS01485
gene id: 453591:IGNI_RS01485
uniprot id: A8A969
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

453591:IGNI RS00970
gene id: 453591:IGNI_RS00970
uniprot id: A8A8W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

453591:IGNI RS05915
gene id: 453591:IGNI_RS05915
uniprot id: A8ABM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

453591:IGNI RS07075
gene id: 453591:IGNI_RS07075
uniprot id: A8AC90
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

453591:IGNI RS07270
gene id: 453591:IGNI_RS07270
uniprot id: A8ACC5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

453591:IGNI RS00575
gene id: 453591:IGNI_RS00575
uniprot id: A8A8P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

453591:IGNI RS02730
gene id: 453591:IGNI_RS02730
uniprot id: A8A9V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

453591:IGNI RS03295
gene id: 453591:IGNI_RS03295
uniprot id: A8AA62
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

453591:IGNI RS04775
gene id: 453591:IGNI_RS04775
uniprot id: A8AB06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

453591:IGNI RS07325
gene id: 453591:IGNI_RS07325
uniprot id: A8ACD4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

453591:IGNI RS07435
gene id: 453591:IGNI_RS07435
uniprot id: A8ACF7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

453591:IGNI RS06970
gene id: 453591:IGNI_RS06970
uniprot id: A8AC72
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

453591:IGNI RS06980
gene id: 453591:IGNI_RS06980
uniprot id: A8AC74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

453591:IGNI RS02830
gene id: 453591:IGNI_RS02830
uniprot id: A8A9X7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

453591:IGNI RS00670
gene id: 453591:IGNI_RS00670
uniprot id: A8A8R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

453591:IGNI RS00765
gene id: 453591:IGNI_RS00765
uniprot id: A8A8S9
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS06825
gene id: 453591:IGNI_RS06825
uniprot id: A8AC48
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS04120
gene id: 453591:IGNI_RS04120
uniprot id: A8AAM9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

453591:IGNI RS06725
gene id: 453591:IGNI_RS06725
uniprot id: A8AC29
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

453591:IGNI RS06425
gene id: 453591:IGNI_RS06425
uniprot id: A8ABX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

453591:IGNI RS06675
gene id: 453591:IGNI_RS06675
uniprot id: A8AC19
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

453591:IGNI RS02645
gene id: 453591:IGNI_RS02645
uniprot id: A8A9U3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

453591:IGNI RS04965
gene id: 453591:IGNI_RS04965
uniprot id: A8AB44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

453591:IGNI RS07400
gene id: 453591:IGNI_RS07400
uniprot id: A8ACE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

453591:IGNI RS03615
gene id: 453591:IGNI_RS03615
uniprot id: A8AAC8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS00335
gene id: 453591:IGNI_RS00335
uniprot id: A8A8J3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

453591:IGNI RS00780
gene id: 453591:IGNI_RS00780
uniprot id: A8A8T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

453591:IGNI RS00145
gene id: 453591:IGNI_RS00145
uniprot id: A8A8F7
names: Similarity
messages: Belongs to the AOR/FOR family.

453591:IGNI RS05660
gene id: 453591:IGNI_RS05660
uniprot id: A8ABH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

453591:IGNI RS06055
gene id: 453591:IGNI_RS06055
uniprot id: A8ABQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

453591:IGNI RS00550
gene id: 453591:IGNI_RS00550
uniprot id: A8A8N5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

453591:IGNI RS02505
gene id: 453591:IGNI_RS02505
uniprot id: A8A9R5
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

453591:IGNI RS01465
gene id: 453591:IGNI_RS01465
uniprot id: A8A965
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS02025
gene id: 453591:IGNI_RS02025
uniprot id: A8A9H3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

453591:IGNI RS06020
gene id: 453591:IGNI_RS06020
uniprot id: A8ABP5
names: Similarity
messages: Belongs to the HerA family.

453591:IGNI RS01150
gene id: 453591:IGNI_RS01150
uniprot id: A8A903
names: Similarity
messages: Belongs to the HerA family.

453591:IGNI RS00100
gene id: 453591:IGNI_RS00100
uniprot id: A8A8E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

453591:IGNI RS03765
gene id: 453591:IGNI_RS03765
uniprot id: A8AAF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.

453591:IGNI RS00665
gene id: 453591:IGNI_RS00665
uniprot id: A8A8Q9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

453591:IGNI RS04570
gene id: 453591:IGNI_RS04570
uniprot id: A8AAW6
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS03070
gene id: 453591:IGNI_RS03070
uniprot id: A8AA20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS04815
gene id: 453591:IGNI_RS04815
uniprot id: A8AB14
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

453591:IGNI RS06570
gene id: 453591:IGNI_RS06570
uniprot id: A8AC01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

453591:IGNI RS00460
gene id: 453591:IGNI_RS00460
uniprot id: A8A8L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

453591:IGNI RS05830
gene id: 453591:IGNI_RS05830
uniprot id: A8ABK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

453591:IGNI RS00285
gene id: 453591:IGNI_RS00285
uniprot id: A8A8I4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

453591:IGNI RS00245
gene id: 453591:IGNI_RS00245
uniprot id: A8A8H6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

453591:IGNI RS00425
gene id: 453591:IGNI_RS00425
uniprot id: A8A8L0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

453591:IGNI RS06230
gene id: 453591:IGNI_RS06230
uniprot id: A8ABT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

453591:IGNI RS00675
gene id: 453591:IGNI_RS00675
uniprot id: A8A8R1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

453591:IGNI RS03065
gene id: 453591:IGNI_RS03065
uniprot id: A8AA19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

453591:IGNI RS01165
gene id: 453591:IGNI_RS01165
uniprot id: A8A906
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

453591:IGNI RS02535
gene id: 453591:IGNI_RS02535
uniprot id: A8A9S1
names: Similarity
messages: Belongs to the HypE family.

453591:IGNI RS03360
gene id: 453591:IGNI_RS03360
uniprot id: A8AA75
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

453591:IGNI RS01670
gene id: 453591:IGNI_RS01670
uniprot id: A8A9A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

453591:IGNI RS01405
gene id: 453591:IGNI_RS01405
uniprot id: A8A954
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

453591:IGNI RS05690
gene id: 453591:IGNI_RS05690
uniprot id: A8ABI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

453591:IGNI RS01625
gene id: 453591:IGNI_RS01625
uniprot id: A8A995
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

453591:IGNI RS04090
gene id: 453591:IGNI_RS04090
uniprot id: A8AAM3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

453591:IGNI RS01125
gene id: 453591:IGNI_RS01125
uniprot id: A8A8Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

453591:IGNI RS07165
gene id: 453591:IGNI_RS07165
uniprot id: A8ACA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

453591:IGNI RS05045
gene id: 453591:IGNI_RS05045
uniprot id: A8AB58
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

453591:IGNI RS04665
gene id: 453591:IGNI_RS04665
uniprot id: A8AAY4
names: Similarity
messages: Belongs to the glutaredoxin family.

453591:IGNI RS00990
gene id: 453591:IGNI_RS00990
uniprot id: A8A8X1
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

453591:IGNI RS06490
gene id: 453591:IGNI_RS06490
uniprot id: A8ABY5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

453591:IGNI RS05115
gene id: 453591:IGNI_RS05115
uniprot id: A8AB71
names: Similarity
messages: Belongs to the AAA ATPase family.

453591:IGNI RS06580
gene id: 453591:IGNI_RS06580
uniprot id: A8AC03
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

453591:IGNI RS03445
gene id: 453591:IGNI_RS03445
uniprot id: A8AA94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

453591:IGNI RS05075
gene id: 453591:IGNI_RS05075
uniprot id: A8AB65
names: Subcellular Location Annotation
messages: Nucleus

453591:IGNI RS01415
gene id: 453591:IGNI_RS01415
uniprot id: A8A956
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

453591:IGNI RS04730
gene id: 453591:IGNI_RS04730
uniprot id: A8AAZ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

453591:IGNI RS06985
gene id: 453591:IGNI_RS06985
uniprot id: A8AC75
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS00810
gene id: 453591:IGNI_RS00810
uniprot id: A8A8T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

453591:IGNI RS04145
gene id: 453591:IGNI_RS04145
uniprot id: A8AAN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

453591:IGNI RS00450
gene id: 453591:IGNI_RS00450
uniprot id: A8A8L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

453591:IGNI RS02815
gene id: 453591:IGNI_RS02815
uniprot id: A8A9X4
names: Similarity
messages: Belongs to the complex I subunit 3 family.

453591:IGNI RS01005
gene id: 453591:IGNI_RS01005
uniprot id: A8A8X4
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS07265
gene id: 453591:IGNI_RS07265
uniprot id: A8ACC4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

453591:IGNI RS01790
gene id: 453591:IGNI_RS01790
uniprot id: A8A9C7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

453591:IGNI RS07315
gene id: 453591:IGNI_RS07315
uniprot id: A8ACD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

453591:IGNI RS00315
gene id: 453591:IGNI_RS00315
uniprot id: A8A8J0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

453591:IGNI RS04565
gene id: 453591:IGNI_RS04565
uniprot id: A8AAW5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

453591:IGNI RS01310
gene id: 453591:IGNI_RS01310
uniprot id: A8A935
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

453591:IGNI RS05900
gene id: 453591:IGNI_RS05900
uniprot id: A8ABM2
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS07105
gene id: 453591:IGNI_RS07105
uniprot id: A8AC96
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

453591:IGNI RS05675
gene id: 453591:IGNI_RS05675
uniprot id: A8ABH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

453591:IGNI RS07220
gene id: 453591:IGNI_RS07220
uniprot id: A8ACB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

453591:IGNI RS03545
gene id: 453591:IGNI_RS03545
uniprot id: A8AAB4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

453591:IGNI RS03500
gene id: 453591:IGNI_RS03500
uniprot id: A8AAA4
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

453591:IGNI RS05200
gene id: 453591:IGNI_RS05200
uniprot id: A8AB87
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS00805
gene id: 453591:IGNI_RS00805
uniprot id: A8A8T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

453591:IGNI RS03530
gene id: 453591:IGNI_RS03530
uniprot id: A8AAB0
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

453591:IGNI RS03790
gene id: 453591:IGNI_RS03790
uniprot id: A8AAG3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

453591:IGNI RS00385
gene id: 453591:IGNI_RS00385
uniprot id: A8A8K2
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

453591:IGNI RS06690
gene id: 453591:IGNI_RS06690
uniprot id: A8AC22
names: Subcellular Location Annotation
messages: Nucleus

453591:IGNI RS01480
gene id: 453591:IGNI_RS01480
uniprot id: A8A968
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

453591:IGNI RS01190
gene id: 453591:IGNI_RS01190
uniprot id: A8A911
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.

453591:IGNI RS02745
gene id: 453591:IGNI_RS02745
uniprot id: A8A9W1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

453591:IGNI RS05035
gene id: 453591:IGNI_RS05035
uniprot id: A8AB56
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

453591:IGNI RS06275
gene id: 453591:IGNI_RS06275
uniprot id: A8ABU1
names: Similarity
messages: Belongs to the UPF0166 family.

453591:IGNI RS03290
gene id: 453591:IGNI_RS03290
uniprot id: A8AA61
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

453591:IGNI RS05055
gene id: 453591:IGNI_RS05055
uniprot id: A8AB60
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

453591:IGNI RS06620
gene id: 453591:IGNI_RS06620
uniprot id: A8AC11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

453591:IGNI RS03770
gene id: 453591:IGNI_RS03770
uniprot id: A8AAF9
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS04265
gene id: 453591:IGNI_RS04265
uniprot id: A8AAQ5
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

453591:IGNI RS04925
gene id: 453591:IGNI_RS04925
uniprot id: A8AB36
names: Similarity
messages: Belongs to the UPF0201 family.

453591:IGNI RS05085
gene id: 453591:IGNI_RS05085
uniprot id: A8AB67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

453591:IGNI RS06445
gene id: 453591:IGNI_RS06445
uniprot id: A8ABX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

453591:IGNI RS00085
gene id: 453591:IGNI_RS00085
uniprot id: A8A8E5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

453591:IGNI RS04330
gene id: 453591:IGNI_RS04330
uniprot id: A8AAR8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

453591:IGNI RS06090
gene id: 453591:IGNI_RS06090
uniprot id: A8ABQ9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

453591:IGNI RS05790
gene id: 453591:IGNI_RS05790
uniprot id: A8ABK0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

453591:IGNI RS05180
gene id: 453591:IGNI_RS05180
uniprot id: A8AB83
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

453591:IGNI RS06625
gene id: 453591:IGNI_RS06625
uniprot id: A8AC12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

453591:IGNI RS05140
gene id: 453591:IGNI_RS05140
uniprot id: A8AB76
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

453591:IGNI RS06455
gene id: 453591:IGNI_RS06455
uniprot id: A8ABX8
names: Similarity
messages: Belongs to the UPF0173 family.

453591:IGNI RS05575
gene id: 453591:IGNI_RS05575
uniprot id: A8ABF9
names: Subcellular Location Annotation
messages: Membrane

453591:IGNI RS01505
gene id: 453591:IGNI_RS01505
uniprot id: A8A972
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

453591:IGNI RS04475
gene id: 453591:IGNI_RS04475
uniprot id: A8AAU7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

453591:IGNI RS04240
gene id: 453591:IGNI_RS04240
uniprot id: A8AAQ2
names: Similarity
messages: Belongs to the BtpA family.

453591:IGNI RS00355
gene id: 453591:IGNI_RS00355
uniprot id: A8A8J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS03640
gene id: 453591:IGNI_RS03640
uniprot id: A8AAD3
names: Similarity
messages: Belongs to the UPF0045 family.

453591:IGNI RS04870
gene id: 453591:IGNI_RS04870
uniprot id: A8AB25
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

453591:IGNI RS03800
gene id: 453591:IGNI_RS03800
uniprot id: A8AAG5
names: Similarity
messages: Belongs to the HerA family.

453591:IGNI RS01025
gene id: 453591:IGNI_RS01025
uniprot id: A8A8X8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

453591:IGNI RS00420
gene id: 453591:IGNI_RS00420
uniprot id: A8A8K9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

453591:IGNI RS01425
gene id: 453591:IGNI_RS01425
uniprot id: A8A958
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

453591:IGNI RS03535
gene id: 453591:IGNI_RS03535
uniprot id: A8AAB2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

453591:IGNI RS01875
gene id: 453591:IGNI_RS01875
uniprot id: A8A9E3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

453591:IGNI RS06470
gene id: 453591:IGNI_RS06470
uniprot id: A8ABY1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

453591:IGNI RS07490
gene id: 453591:IGNI_RS07490
uniprot id: A8ACG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

453591:IGNI RS01460
gene id: 453591:IGNI_RS01460
uniprot id: A8A964
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

453591:IGNI RS04010
gene id: 453591:IGNI_RS04010
uniprot id: A8AAK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

453591:IGNI RS00465
gene id: 453591:IGNI_RS00465
uniprot id: A8A8L8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

453591:IGNI RS02975
gene id: 453591:IGNI_RS02975
uniprot id: A8AA02
names: Similarity
messages: Belongs to the HupF/HypC family.

453591:IGNI RS05315
gene id: 453591:IGNI_RS05315
uniprot id: A8ABA9
names: Similarity
messages: Belongs to the AOR/FOR family.

453591:IGNI RS05800
gene id: 453591:IGNI_RS05800
uniprot id: A8ABK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

453591:IGNI RS02410
gene id: 453591:IGNI_RS02410
uniprot id: A8A9P6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

453591:IGNI RS01195
gene id: 453591:IGNI_RS01195
uniprot id: A8A912
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

453591:IGNI RS06560
gene id: 453591:IGNI_RS06560
uniprot id: A8ABZ9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

453591:IGNI RS03960
gene id: 453591:IGNI_RS03960
uniprot id: A8AAJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

453591:IGNI RS01280
gene id: 453591:IGNI_RS01280
uniprot id: A8A929
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

453591:IGNI RS03310
gene id: 453591:IGNI_RS03310
uniprot id: A8AA65
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

453591:IGNI RS04395
gene id: 453591:IGNI_RS04395
uniprot id: A8AAT2
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

453591:IGNI RS01395
gene id: 453591:IGNI_RS01395
uniprot id: A8A952
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS07230
gene id: 453591:IGNI_RS07230
uniprot id: A8ACB7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

453591:IGNI RS04525
gene id: 453591:IGNI_RS04525
uniprot id: A8AAV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

453591:IGNI RS05375
gene id: 453591:IGNI_RS05375
uniprot id: A8ABC0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

453591:IGNI RS04950
gene id: 453591:IGNI_RS04950
uniprot id: A8AB41
names: Similarity
messages: Belongs to the RuvB family.

453591:IGNI RS07485
gene id: 453591:IGNI_RS07485
uniprot id: A8ACG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

453591:IGNI RS02345
gene id: 453591:IGNI_RS02345
uniprot id: A8A9N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

453591:IGNI RS00490
gene id: 453591:IGNI_RS00490
uniprot id: A8A8M4
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

453591:IGNI RS03955
gene id: 453591:IGNI_RS03955
uniprot id: A8AAJ7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

453591:IGNI RS03240
gene id: 453591:IGNI_RS03240
uniprot id: A8AA52
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

453591:IGNI RS04790
gene id: 453591:IGNI_RS04790
uniprot id: A8AB09
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.