449:LHA RS10430
gene id: 449:LHA_RS10430
uniprot id: A0A0A8UWX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

449:LHA RS04305
gene id: 449:LHA_RS04305
uniprot id: A0A0A8UR60
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

449:LHA RS07050
gene id: 449:LHA_RS07050
uniprot id: A0A0A8UNY3
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

449:LHA RS09570
gene id: 449:LHA_RS09570
uniprot id: A0A0A8UQH1
names: Function
names: Similarity
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

449:LHA RS08515
gene id: 449:LHA_RS08515
uniprot id: A0A0A8UVR2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

449:LHA RS10610
gene id: 449:LHA_RS10610
uniprot id: A0A0A8UUV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

449:LHA RS05505
gene id: 449:LHA_RS05505
uniprot id: A0A0A8URV8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

449:LHA RS09090
gene id: 449:LHA_RS09090
uniprot id: A0A0A8UQG9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

449:LHA RS04210
gene id: 449:LHA_RS04210
uniprot id: A0A0A8UR34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

449:LHA RS09415
gene id: 449:LHA_RS09415
uniprot id: A0A0A8UQD5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

449:LHA RS00910
gene id: 449:LHA_RS00910
uniprot id: A0A0A8UKB8
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

449:LHA RS06135
gene id: 449:LHA_RS06135
uniprot id: A0A0A8UUB0
names: Similarity
messages: Belongs to the Gfa family.

449:LHA RS14400
gene id: 449:LHA_RS14400
uniprot id: A0A0A8UX33
names: Similarity
messages: Belongs to the PhoH family.

449:LHA RS02310
gene id: 449:LHA_RS02310
uniprot id: A0A0A8UL88
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

449:LHA RS14020
gene id: 449:LHA_RS14020
uniprot id: A0A0A8UWT9
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS04565
gene id: 449:LHA_RS04565
uniprot id: A0A0A8URC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

449:LHA RS02545
gene id: 449:LHA_RS02545
uniprot id: A0A0A8UQ87
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

449:LHA RS02080
gene id: 449:LHA_RS02080
uniprot id: A0A0A8UR50
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

449:LHA RS02120
gene id: 449:LHA_RS02120
uniprot id: A0A0A8UL34
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS09700
gene id: 449:LHA_RS09700
uniprot id: A0A0A8UUF2
names: Similarity
messages: Belongs to the polysaccharide synthase family.

449:LHA RS00760
gene id: 449:LHA_RS00760
uniprot id: A0A0A8UKN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

449:LHA RS08245
gene id: 449:LHA_RS08245
uniprot id: A0A0A8UUQ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

449:LHA RS09460
gene id: 449:LHA_RS09460
uniprot id: A0A0A8UWD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

449:LHA RS03250
gene id: 449:LHA_RS03250
uniprot id: A0A0A8ULN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

449:LHA RS11350
gene id: 449:LHA_RS11350
uniprot id: A0A0A8UV99
names: Similarity
messages: Belongs to the UPF0276 family.

449:LHA RS15675
gene id: 449:LHA_RS15675
uniprot id: A0A0A8V001
names: Similarity
messages: Belongs to the ParB family.

449:LHA RS08460
gene id: 449:LHA_RS08460
uniprot id: A0A0A8UQ19
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome
messages: Secreted

449:LHA RS04510
gene id: 449:LHA_RS04510
uniprot id: A0A0A8UTE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M4 family.
messages: Extracellular zinc metalloprotease.
messages: Secreted

449:LHA RS11380
gene id: 449:LHA_RS11380
uniprot id: A0A0A8UWH7
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS06715
gene id: 449:LHA_RS06715
uniprot id: A0A0A8USJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinylarginine dihydrolase family.
messages: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
messages: Homodimer.

449:LHA RS15285
gene id: 449:LHA_RS15285
uniprot id: A0A0A8UZS0
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS10540
gene id: 449:LHA_RS10540
uniprot id: A0A0A8URB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

449:LHA RS07530
gene id: 449:LHA_RS07530
uniprot id: A0A0A8UP87
names: Similarity
messages: Belongs to the citrate synthase family.

449:LHA RS02150
gene id: 449:LHA_RS02150
uniprot id: A0A0A8UPY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

449:LHA RS08345
gene id: 449:LHA_RS08345
uniprot id: A0A0A8UPZ3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

449:LHA RS08235
gene id: 449:LHA_RS08235
uniprot id: A0A0A8UPK6
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

449:LHA RS10325
gene id: 449:LHA_RS10325
uniprot id: A0A0A8UVX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

449:LHA RS08835
gene id: 449:LHA_RS08835
uniprot id: A0A0A8UVY0
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS08990
gene id: 449:LHA_RS08990
uniprot id: A0A0A8UV44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

449:LHA RS04545
gene id: 449:LHA_RS04545
uniprot id: A0A0A8URB5
names: Similarity
messages: Belongs to the glutamine synthetase family.

449:LHA RS15215
gene id: 449:LHA_RS15215
uniprot id: A0A0A8UZQ6
names: Similarity
messages: Belongs to the transposase 7 family.

449:LHA RS13500
gene id: 449:LHA_RS13500
uniprot id: A0A0A8UWH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

449:LHA RS15480
gene id: 449:LHA_RS15480
uniprot id: A0A0A8UTV7
names: Similarity
messages: Belongs to the UPF0310 family.

449:LHA RS05795
gene id: 449:LHA_RS05795
uniprot id: A0A0A8UT90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

449:LHA RS03215
gene id: 449:LHA_RS03215
uniprot id: A0A0A8UM14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

449:LHA RS02510
gene id: 449:LHA_RS02510
uniprot id: A0A0A8USC0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

449:LHA RS03375
gene id: 449:LHA_RS03375
uniprot id: A0A0A8ULQ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

449:LHA RS01230
gene id: 449:LHA_RS01230
uniprot id: A0A0A8UQK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

449:LHA RS04520
gene id: 449:LHA_RS04520
uniprot id: A0A0A8URB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

449:LHA RS01925
gene id: 449:LHA_RS01925
uniprot id: A0A0A8UPT5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

449:LHA RS00305
gene id: 449:LHA_RS00305
uniprot id: A0A0A8UNX1
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

449:LHA RS08800
gene id: 449:LHA_RS08800
uniprot id: A0A0A8UV01
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

449:LHA RS11215
gene id: 449:LHA_RS11215
uniprot id: A0A0A8UXD4
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

449:LHA RS12380
gene id: 449:LHA_RS12380
uniprot id: A0A0A8UY48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

449:LHA RS02245
gene id: 449:LHA_RS02245
uniprot id: A0A0A8UQ06
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03920
gene id: 449:LHA_RS03920
uniprot id: A0A0A8US41
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS05950
gene id: 449:LHA_RS05950
uniprot id: A0A0A8UNJ9
names: Similarity
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.

449:LHA RS06520
gene id: 449:LHA_RS06520
uniprot id: A0A0A8USE1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

449:LHA RS09580
gene id: 449:LHA_RS09580
uniprot id: A0A0A8UVG5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

449:LHA RS03845
gene id: 449:LHA_RS03845
uniprot id: A0A0A8US24
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

449:LHA RS02585
gene id: 449:LHA_RS02585
uniprot id: A0A0A8USC8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

449:LHA RS10075
gene id: 449:LHA_RS10075
uniprot id: A0A0A8UUL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane
messages: Required for nicotinamide riboside transport across the inner membrane.

449:LHA RS14985
gene id: 449:LHA_RS14985
uniprot id: A0A0A8UTM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

449:LHA RS04840
gene id: 449:LHA_RS04840
uniprot id: A0A0A8USU1
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

449:LHA RS12450
gene id: 449:LHA_RS12450
uniprot id: A0A0A8USI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

449:LHA RS12745
gene id: 449:LHA_RS12745
uniprot id: A0A0A8USA1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

449:LHA RS11330
gene id: 449:LHA_RS11330
uniprot id: A0A0A8UWG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

449:LHA RS03360
gene id: 449:LHA_RS03360
uniprot id: A0A0A8URT7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS07580
gene id: 449:LHA_RS07580
uniprot id: A0A0A8UUC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

449:LHA RS08465
gene id: 449:LHA_RS08465
uniprot id: A0A0A8UVQ4
names: Similarity
messages: Belongs to the histone deacetylase family.

449:LHA RS06180
gene id: 449:LHA_RS06180
uniprot id: A0A0A8UUC1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS12905
gene id: 449:LHA_RS12905
uniprot id: A0A0A8UXD1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS00455
gene id: 449:LHA_RS00455
uniprot id: A0A0A8UQ68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

449:LHA RS00080
gene id: 449:LHA_RS00080
uniprot id: A0A0A8UJZ0
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

449:LHA RS04260
gene id: 449:LHA_RS04260
uniprot id: A0A0A8USC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

449:LHA RS07525
gene id: 449:LHA_RS07525
uniprot id: A0A0A8UV72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
messages: Homotetramer; dimer of dimers.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.

449:LHA RS03315
gene id: 449:LHA_RS03315
uniprot id: A0A0A8ULP5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

449:LHA RS05640
gene id: 449:LHA_RS05640
uniprot id: A0A0A8UNE9
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS14140
gene id: 449:LHA_RS14140
uniprot id: A0A0A8UWW8
names: Similarity
messages: Belongs to the peptidase M1 family.

449:LHA RS06720
gene id: 449:LHA_RS06720
uniprot id: A0A0A8UTR6
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family. AstD subfamily.
messages: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.

449:LHA RS15165
gene id: 449:LHA_RS15165
uniprot id: A0A0A8UTP9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS11780
gene id: 449:LHA_RS11780
uniprot id: A0A0A8UWR2
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS10025
gene id: 449:LHA_RS10025
uniprot id: A0A0A8UVS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

449:LHA RS03735
gene id: 449:LHA_RS03735
uniprot id: A0A0A8ULY0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

449:LHA RS08405
gene id: 449:LHA_RS08405
uniprot id: A0A0A8UUS9
names: Similarity
messages: Belongs to the glutamine synthetase family.

449:LHA RS10785
gene id: 449:LHA_RS10785
uniprot id: A0A0A8UR31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

449:LHA RS13880
gene id: 449:LHA_RS13880
uniprot id: A0A0A8UYZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

449:LHA RS11680
gene id: 449:LHA_RS11680
uniprot id: A0A0A8UWP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

449:LHA RS00830
gene id: 449:LHA_RS00830
uniprot id: A0A0A8URA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

449:LHA RS08765
gene id: 449:LHA_RS08765
uniprot id: A0A0A8UPX3
names: Similarity
messages: Belongs to the thioredoxin family.

449:LHA RS05800
gene id: 449:LHA_RS05800
uniprot id: A0A0A8UNH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

449:LHA RS11930
gene id: 449:LHA_RS11930
uniprot id: A0A0A8US73
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS13650
gene id: 449:LHA_RS13650
uniprot id: A0A0A8UWK2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

449:LHA RS10930
gene id: 449:LHA_RS10930
uniprot id: A0A0A8UX68
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS08855
gene id: 449:LHA_RS08855
uniprot id: A0A0A8UQB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

449:LHA RS02735
gene id: 449:LHA_RS02735
uniprot id: A0A0A8ULF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

449:LHA RS10045
gene id: 449:LHA_RS10045
uniprot id: A0A0A8UUK6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

449:LHA RS01645
gene id: 449:LHA_RS01645
uniprot id: A0A0A8UQT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

449:LHA RS01490
gene id: 449:LHA_RS01490
uniprot id: A0A0A8UPG8
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

449:LHA RS13490
gene id: 449:LHA_RS13490
uniprot id: A0A0A8UYQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

449:LHA RS13400
gene id: 449:LHA_RS13400
uniprot id: A0A0A8USN2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

449:LHA RS15745
gene id: 449:LHA_RS15745
uniprot id: A0A0A8UUF7
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

449:LHA RS08565
gene id: 449:LHA_RS08565
uniprot id: A0A0A8UPT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

449:LHA RS08350
gene id: 449:LHA_RS08350
uniprot id: A0A0A8UVN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

449:LHA RS10380
gene id: 449:LHA_RS10380
uniprot id: A0A0A8UWX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

449:LHA RS01420
gene id: 449:LHA_RS01420
uniprot id: A0A0A8UPG2
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

449:LHA RS07690
gene id: 449:LHA_RS07690
uniprot id: A0A0A8UVA0
names: Similarity
messages: Belongs to the intimin/invasin family.

449:LHA RS13210
gene id: 449:LHA_RS13210
uniprot id: A0A0A8USJ1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03210
gene id: 449:LHA_RS03210
uniprot id: A0A0A8URR4
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

449:LHA RS01935
gene id: 449:LHA_RS01935
uniprot id: A0A0A8ULB6
names: Similarity
messages: Belongs to the peptidase S1C family.

449:LHA RS14860
gene id: 449:LHA_RS14860
uniprot id: A0A0A8UZK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

449:LHA RS01780
gene id: 449:LHA_RS01780
uniprot id: A0A0A8UPP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

449:LHA RS15460
gene id: 449:LHA_RS15460
uniprot id: A0A0A8UXP2
names: Similarity
messages: Belongs to the UPF0235 family.

449:LHA RS12740
gene id: 449:LHA_RS12740
uniprot id: A0A0A8UYA5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

449:LHA RS15335
gene id: 449:LHA_RS15335
uniprot id: A0A0A8UZT1
names: Similarity
messages: Belongs to the class-D beta-lactamase family.

449:LHA RS02720
gene id: 449:LHA_RS02720
uniprot id: A0A0A8URI6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

449:LHA RS06515
gene id: 449:LHA_RS06515
uniprot id: A0A0A8UNJ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

449:LHA RS06150
gene id: 449:LHA_RS06150
uniprot id: A0A0A8UTF0
names: Similarity
messages: Belongs to the class-A beta-lactamase family.

449:LHA RS10225
gene id: 449:LHA_RS10225
uniprot id: A0A0A8UUN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

449:LHA RS05790
gene id: 449:LHA_RS05790
uniprot id: A0A0A8US02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

449:LHA RS08570
gene id: 449:LHA_RS08570
uniprot id: A0A0A8UTM1
names: Similarity
messages: Belongs to the YkuD family.

449:LHA RS07745
gene id: 449:LHA_RS07745
uniprot id: A0A0A8UPB7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

449:LHA RS02885
gene id: 449:LHA_RS02885
uniprot id: A0A0A8ULH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

449:LHA RS10510
gene id: 449:LHA_RS10510
uniprot id: A0A0A8UW14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

449:LHA RS08110
gene id: 449:LHA_RS08110
uniprot id: A0A0A8UVJ2
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS08705
gene id: 449:LHA_RS08705
uniprot id: A0A0A8UQ71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

449:LHA RS10265
gene id: 449:LHA_RS10265
uniprot id: A0A0A8UWU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS11235
gene id: 449:LHA_RS11235
uniprot id: A0A0A8URQ3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

449:LHA RS13050
gene id: 449:LHA_RS13050
uniprot id: A0A0A8UST3
names: Similarity
messages: Belongs to the ArsC family.

449:LHA RS00500
gene id: 449:LHA_RS00500
uniprot id: A0A0A8UQ77
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

449:LHA RS09275
gene id: 449:LHA_RS09275
uniprot id: A0A0A8UU25
names: Similarity
messages: Belongs to the peptidase C56 family.

449:LHA RS13660
gene id: 449:LHA_RS13660
uniprot id: A0A0A8UT65
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

449:LHA RS09420
gene id: 449:LHA_RS09420
uniprot id: A0A0A8UU57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

449:LHA RS10145
gene id: 449:LHA_RS10145
uniprot id: A0A0A8UQS2
names: Similarity
messages: Belongs to the AlaDH/PNT family.

449:LHA RS03690
gene id: 449:LHA_RS03690
uniprot id: A0A0A8UQR3
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03790
gene id: 449:LHA_RS03790
uniprot id: A0A0A8UQT1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

449:LHA RS04235
gene id: 449:LHA_RS04235
uniprot id: A0A0A8USB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

449:LHA RS00235
gene id: 449:LHA_RS00235
uniprot id: A0A0A8UQ38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

449:LHA RS03915
gene id: 449:LHA_RS03915
uniprot id: A0A0A8UQV5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

449:LHA RS03530
gene id: 449:LHA_RS03530
uniprot id: A0A0A8UM57
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

449:LHA RS09720
gene id: 449:LHA_RS09720
uniprot id: A0A0A8UQL9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

449:LHA RS02765
gene id: 449:LHA_RS02765
uniprot id: A0A0A8UQB9
names: Similarity
messages: Belongs to the peptidase S41A family.

449:LHA RS08745
gene id: 449:LHA_RS08745
uniprot id: A0A0A8UTQ1
names: Similarity
messages: Belongs to the citrate synthase family.

449:LHA RS10150
gene id: 449:LHA_RS10150
uniprot id: A0A0A8UUM3
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

449:LHA RS00960
gene id: 449:LHA_RS00960
uniprot id: A0A0A8UKC8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

449:LHA RS02860
gene id: 449:LHA_RS02860
uniprot id: A0A0A8ULH4
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

449:LHA RS06885
gene id: 449:LHA_RS06885
uniprot id: A0A0A8USP3
names: Function
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.

449:LHA RS00925
gene id: 449:LHA_RS00925
uniprot id: A0A0A8UKR3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

449:LHA RS12480
gene id: 449:LHA_RS12480
uniprot id: A0A0A8UY60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

449:LHA RS12925
gene id: 449:LHA_RS12925
uniprot id: A0A0A8UW70
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

449:LHA RS14030
gene id: 449:LHA_RS14030
uniprot id: A0A0A8UTE6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS05935
gene id: 449:LHA_RS05935
uniprot id: A0A0A8UN79
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS14100
gene id: 449:LHA_RS14100
uniprot id: A0A0A8UTG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

449:LHA RS03475
gene id: 449:LHA_RS03475
uniprot id: A0A0A8URV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

449:LHA RS03095
gene id: 449:LHA_RS03095
uniprot id: A0A0A8URP2
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

449:LHA RS04220
gene id: 449:LHA_RS04220
uniprot id: A0A0A8UMK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS14425
gene id: 449:LHA_RS14425
uniprot id: A0A0A8UX39
names: Similarity
messages: Belongs to the RNase T2 family.

449:LHA RS10165
gene id: 449:LHA_RS10165
uniprot id: A0A0A8UWS8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

449:LHA RS09610
gene id: 449:LHA_RS09610
uniprot id: A0A0A8UQU3
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS05355
gene id: 449:LHA_RS05355
uniprot id: A0A0A8URT6
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS04680
gene id: 449:LHA_RS04680
uniprot id: A0A0A8URF2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

449:LHA RS03130
gene id: 449:LHA_RS03130
uniprot id: A0A0A8USL6
names: Similarity
messages: Belongs to the peptidase S8 family.

449:LHA RS03540
gene id: 449:LHA_RS03540
uniprot id: A0A0A8ULT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

449:LHA RS00840
gene id: 449:LHA_RS00840
uniprot id: A0A0A8UP49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

449:LHA RS06035
gene id: 449:LHA_RS06035
uniprot id: A0A0A8UU92
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

449:LHA RS05850
gene id: 449:LHA_RS05850
uniprot id: A0A0A8UNI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

449:LHA RS11650
gene id: 449:LHA_RS11650
uniprot id: A0A0A8US00
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS08870
gene id: 449:LHA_RS08870
uniprot id: A0A0A8UTS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
messages: Belongs to the GSP E family.
messages: Cell inner membrane

449:LHA RS03785
gene id: 449:LHA_RS03785
uniprot id: A0A0A8ULY9
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

449:LHA RS02155
gene id: 449:LHA_RS02155
uniprot id: A0A0A8UR70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

449:LHA RS09535
gene id: 449:LHA_RS09535
uniprot id: A0A0A8UWF8
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS01045
gene id: 449:LHA_RS01045
uniprot id: A0A0A8UKT4
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS09605
gene id: 449:LHA_RS09605
uniprot id: A0A0A8UVH1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

449:LHA RS06405
gene id: 449:LHA_RS06405
uniprot id: A0A0A8UUG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

449:LHA RS07535
gene id: 449:LHA_RS07535
uniprot id: A0A0A8UT46
names: Similarity
messages: Belongs to the PrpD family.

449:LHA RS07855
gene id: 449:LHA_RS07855
uniprot id: A0A0A8UUG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS12835
gene id: 449:LHA_RS12835
uniprot id: A0A0A8USQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

449:LHA RS07665
gene id: 449:LHA_RS07665
uniprot id: A0A0A8UV95
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

449:LHA RS08435
gene id: 449:LHA_RS08435
uniprot id: A0A0A8UQ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS05345
gene id: 449:LHA_RS05345
uniprot id: A0A0A8UTY0
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS07455
gene id: 449:LHA_RS07455
uniprot id: A0A0A8UP79
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

449:LHA RS01620
gene id: 449:LHA_RS01620
uniprot id: A0A0A8UQT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

449:LHA RS11950
gene id: 449:LHA_RS11950
uniprot id: A0A0A8UWV4
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

449:LHA RS02650
gene id: 449:LHA_RS02650
uniprot id: A0A0A8URH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M4 family.
messages: Extracellular zinc metalloprotease.
messages: Secreted

449:LHA RS03555
gene id: 449:LHA_RS03555
uniprot id: A0A0A8UM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

449:LHA RS04160
gene id: 449:LHA_RS04160
uniprot id: A0A0A8UR20
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

449:LHA RS07325
gene id: 449:LHA_RS07325
uniprot id: A0A0A8UV40
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

449:LHA RS04320
gene id: 449:LHA_RS04320
uniprot id: A0A0A8UTA9
names: Similarity
messages: Belongs to the UPF0434 family.

449:LHA RS05825
gene id: 449:LHA_RS05825
uniprot id: A0A0A8UNH9
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

449:LHA RS04750
gene id: 449:LHA_RS04750
uniprot id: A0A0A8UTL1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

449:LHA RS08265
gene id: 449:LHA_RS08265
uniprot id: A0A0A8UTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

449:LHA RS04500
gene id: 449:LHA_RS04500
uniprot id: A0A0A8USI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP L family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

449:LHA RS08965
gene id: 449:LHA_RS08965
uniprot id: A0A0A8UV35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

449:LHA RS12640
gene id: 449:LHA_RS12640
uniprot id: A0A0A8USL9
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS07410
gene id: 449:LHA_RS07410
uniprot id: A0A0A8UT29
names: Similarity
messages: Belongs to the YfgM family.

449:LHA RS14630
gene id: 449:LHA_RS14630
uniprot id: A0A0A8UZH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

449:LHA RS10715
gene id: 449:LHA_RS10715
uniprot id: A0A0A8UUX3
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

449:LHA RS10845
gene id: 449:LHA_RS10845
uniprot id: A0A0A8UW71
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

449:LHA RS15230
gene id: 449:LHA_RS15230
uniprot id: A0A0A8UYQ0
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS13890
gene id: 449:LHA_RS13890
uniprot id: A0A0A8UWQ9
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

449:LHA RS03125
gene id: 449:LHA_RS03125
uniprot id: A0A0A8UM00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

449:LHA RS14580
gene id: 449:LHA_RS14580
uniprot id: A0A0A8UZG5
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

449:LHA RS03580
gene id: 449:LHA_RS03580
uniprot id: A0A0A8UM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

449:LHA RS08695
gene id: 449:LHA_RS08695
uniprot id: A0A0A8UTP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

449:LHA RS14350
gene id: 449:LHA_RS14350
uniprot id: A0A0A8UY70
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS09000
gene id: 449:LHA_RS09000
uniprot id: A0A0A8UW23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

449:LHA RS03110
gene id: 449:LHA_RS03110
uniprot id: A0A0A8ULL0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

449:LHA RS03060
gene id: 449:LHA_RS03060
uniprot id: A0A0A8ULK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

449:LHA RS05635
gene id: 449:LHA_RS05635
uniprot id: O32766
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family.
messages: Cell outer membrane
messages: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.
messages: Membrane

449:LHA RS07485
gene id: 449:LHA_RS07485
uniprot id: A0A0A8UT39
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS11075
gene id: 449:LHA_RS11075
uniprot id: A0A0A8UR93
names: Subcellular Location Annotation
messages: Cytoplasm

449:LHA RS02760
gene id: 449:LHA_RS02760
uniprot id: A0A0A8ULG2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

449:LHA RS02805
gene id: 449:LHA_RS02805
uniprot id: A0A0A8USG2
names: Similarity
messages: Belongs to the skp family.

449:LHA RS02270
gene id: 449:LHA_RS02270
uniprot id: A0A0A8UR96
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

449:LHA RS12395
gene id: 449:LHA_RS12395
uniprot id: A0A0A8UX56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

449:LHA RS00530
gene id: 449:LHA_RS00530
uniprot id: A0A0A8UKJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

449:LHA RS10375
gene id: 449:LHA_RS10375
uniprot id: A0A0A8UR90
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

449:LHA RS04030
gene id: 449:LHA_RS04030
uniprot id: A0A0A8UQY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0187 family.
messages: Membrane

449:LHA RS12555
gene id: 449:LHA_RS12555
uniprot id: A0A0A8US76
names: Similarity
messages: Belongs to the GSP E family.

449:LHA RS14870
gene id: 449:LHA_RS14870
uniprot id: A0A0A8UXE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

449:LHA RS10940
gene id: 449:LHA_RS10940
uniprot id: A0A0A8UV15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

449:LHA RS15055
gene id: 449:LHA_RS15055
uniprot id: A0A0A8UXH5
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

449:LHA RS08240
gene id: 449:LHA_RS08240
uniprot id: A0A0A8UTF5
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

449:LHA RS08430
gene id: 449:LHA_RS08430
uniprot id: A0A0A8UUT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP J family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS14845
gene id: 449:LHA_RS14845
uniprot id: A0A0A8UXE2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

449:LHA RS04350
gene id: 449:LHA_RS04350
uniprot id: A0A0A8UMB2
names: Similarity
messages: Belongs to the UPF0047 family.

449:LHA RS01025
gene id: 449:LHA_RS01025
uniprot id: A0A0A8URD5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

449:LHA RS13625
gene id: 449:LHA_RS13625
uniprot id: A0A0A8UWJ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS15170
gene id: 449:LHA_RS15170
uniprot id: A0A0A8UXJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

449:LHA RS07280
gene id: 449:LHA_RS07280
uniprot id: A0A0A8UP54
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

449:LHA RS11230
gene id: 449:LHA_RS11230
uniprot id: A0A0A8UWE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

449:LHA RS04265
gene id: 449:LHA_RS04265
uniprot id: A0A0A8UMM1
names: Function
names: Similarity
messages: Belongs to the ADC family.
messages: Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.

449:LHA RS06390
gene id: 449:LHA_RS06390
uniprot id: A0A0A8USB2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

449:LHA RS10270
gene id: 449:LHA_RS10270
uniprot id: A0A0A8UUP6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

449:LHA RS04805
gene id: 449:LHA_RS04805
uniprot id: A0A0A8UMQ0
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

449:LHA RS13375
gene id: 449:LHA_RS13375
uniprot id: A0A0A8USM7
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

449:LHA RS03120
gene id: 449:LHA_RS03120
uniprot id: A0A0A8URP6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS03490
gene id: 449:LHA_RS03490
uniprot id: A0A0A8ULS9
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

449:LHA RS02795
gene id: 449:LHA_RS02795
uniprot id: A0A0A8URJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

449:LHA RS15995
gene id: 449:LHA_RS15995
uniprot id: A0A0A8UTN2
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

449:LHA RS00015
gene id: 449:LHA_RS00015
uniprot id: A0A0A8UJY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

449:LHA RS07670
gene id: 449:LHA_RS07670
uniprot id: A0A0A8UPA7
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

449:LHA RS12515
gene id: 449:LHA_RS12515
uniprot id: A0A0A8UX72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

449:LHA RS05495
gene id: 449:LHA_RS05495
uniprot id: A0A0A8UU05
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

449:LHA RS07045
gene id: 449:LHA_RS07045
uniprot id: A0A0A8UUU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

449:LHA RS13030
gene id: 449:LHA_RS13030
uniprot id: A0A0A8UYF5
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

449:LHA RS10850
gene id: 449:LHA_RS10850
uniprot id: A0A0A8URH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

449:LHA RS08400
gene id: 449:LHA_RS08400
uniprot id: A0A0A8UTI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

449:LHA RS07865
gene id: 449:LHA_RS07865
uniprot id: A0A0A8UPD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MutH family.
messages: Cytoplasm
messages: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.

449:LHA RS00465
gene id: 449:LHA_RS00465
uniprot id: A0A0A8UR38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

449:LHA RS06575
gene id: 449:LHA_RS06575
uniprot id: A0A0A8UTN7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

449:LHA RS07205
gene id: 449:LHA_RS07205
uniprot id: A0A0A8UUY1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

449:LHA RS04340
gene id: 449:LHA_RS04340
uniprot id: A0A0A8UMN3
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS13900
gene id: 449:LHA_RS13900
uniprot id: A0A0A8UTC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

449:LHA RS01020
gene id: 449:LHA_RS01020
uniprot id: A0A0A8UKT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

449:LHA RS08210
gene id: 449:LHA_RS08210
uniprot id: A0A0A8UPK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS13655
gene id: 449:LHA_RS13655
uniprot id: A0A0A8UXR3
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

449:LHA RS13555
gene id: 449:LHA_RS13555
uniprot id: A0A0A8UT41
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS07840
gene id: 449:LHA_RS07840
uniprot id: A0A0A8UVD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS03075
gene id: 449:LHA_RS03075
uniprot id: A0A0A8ULZ1
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

449:LHA RS04885
gene id: 449:LHA_RS04885
uniprot id: A0A0A8UN34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

449:LHA RS04255
gene id: 449:LHA_RS04255
uniprot id: A0A0A8UR46
names: Similarity
messages: Belongs to the MotB family.

449:LHA RS00525
gene id: 449:LHA_RS00525
uniprot id: A0A0A8UQ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Cell inner membrane
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

449:LHA RS08410
gene id: 449:LHA_RS08410
uniprot id: A0A0A8UQ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

449:LHA RS01145
gene id: 449:LHA_RS01145
uniprot id: A0A0A8UKV2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

449:LHA RS06040
gene id: 449:LHA_RS06040
uniprot id: A0A0A8UNA0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

449:LHA RS04315
gene id: 449:LHA_RS04315
uniprot id: A0A0A8UMM8
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

449:LHA RS10210
gene id: 449:LHA_RS10210
uniprot id: A0A0A8UR63
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS05855
gene id: 449:LHA_RS05855
uniprot id: A0A0A8UU65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

449:LHA RS01505
gene id: 449:LHA_RS01505
uniprot id: A0A0A8URN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

449:LHA RS12820
gene id: 449:LHA_RS12820
uniprot id: A0A0A8USB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

449:LHA RS03570
gene id: 449:LHA_RS03570
uniprot id: A0A0A8UQN8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

449:LHA RS10625
gene id: 449:LHA_RS10625
uniprot id: A0A0A8UX15
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

449:LHA RS03410
gene id: 449:LHA_RS03410
uniprot id: A0A0A8UQL0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

449:LHA RS07390
gene id: 449:LHA_RS07390
uniprot id: A0A0A8UUA3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

449:LHA RS13430
gene id: 449:LHA_RS13430
uniprot id: A0A0A8UXM6
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

449:LHA RS14370
gene id: 449:LHA_RS14370
uniprot id: A0A0A8UX25
names: Similarity
messages: Belongs to the peptidase M20A family. ArgE subfamily.

449:LHA RS15025
gene id: 449:LHA_RS15025
uniprot id: A0A0A8UU27
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03040
gene id: 449:LHA_RS03040
uniprot id: A0A0A8UQG0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

449:LHA RS01950
gene id: 449:LHA_RS01950
uniprot id: A0A0A8UPU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

449:LHA RS08315
gene id: 449:LHA_RS08315
uniprot id: A0A0A8UUR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

449:LHA RS01890
gene id: 449:LHA_RS01890
uniprot id: A0A0A8ULA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

449:LHA RS11270
gene id: 449:LHA_RS11270
uniprot id: A0A0A8URC9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS05615
gene id: 449:LHA_RS05615
uniprot id: A0A0A8UNE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

449:LHA RS04880
gene id: 449:LHA_RS04880
uniprot id: A0A0A8USU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

449:LHA RS08840
gene id: 449:LHA_RS08840
uniprot id: A0A0A8UPY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

449:LHA RS12415
gene id: 449:LHA_RS12415
uniprot id: A0A0A8UVZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

449:LHA RS02940
gene id: 449:LHA_RS02940
uniprot id: A0A0A8UQE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

449:LHA RS00230
gene id: 449:LHA_RS00230
uniprot id: A0A0A8UNW0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

449:LHA RS13040
gene id: 449:LHA_RS13040
uniprot id: A0A0A8UW84
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

449:LHA RS02100
gene id: 449:LHA_RS02100
uniprot id: A0A0A8UPX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

449:LHA RS13495
gene id: 449:LHA_RS13495
uniprot id: A0A0A8USQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

449:LHA RS01675
gene id: 449:LHA_RS01675
uniprot id: A0A0A8URS3
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

449:LHA RS03310
gene id: 449:LHA_RS03310
uniprot id: A0A0A8USP5
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

449:LHA RS05480
gene id: 449:LHA_RS05480
uniprot id: A0A0A8URV4
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

449:LHA RS09600
gene id: 449:LHA_RS09600
uniprot id: A0A0A8UU95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

449:LHA RS07645
gene id: 449:LHA_RS07645
uniprot id: A0A0A8UPA3
names: Similarity
messages: Belongs to the UPF0250 family.

449:LHA RS08355
gene id: 449:LHA_RS08355
uniprot id: A0A0A8UPN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

449:LHA RS07880
gene id: 449:LHA_RS07880
uniprot id: A0A0A8UPR2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS15530
gene id: 449:LHA_RS15530
uniprot id: A0A0A8UZW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

449:LHA RS11955
gene id: 449:LHA_RS11955
uniprot id: A0A0A8US79
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

449:LHA RS08250
gene id: 449:LHA_RS08250
uniprot id: A0A0A8UPX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

449:LHA RS06780
gene id: 449:LHA_RS06780
uniprot id: A0A0A8UNR1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

449:LHA RS10730
gene id: 449:LHA_RS10730
uniprot id: A0A0A8UR19
names: Similarity
messages: Belongs to the Dps family.

449:LHA RS12885
gene id: 449:LHA_RS12885
uniprot id: A0A0A8USR0
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

449:LHA RS09440
gene id: 449:LHA_RS09440
uniprot id: A0A0A8UQE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

449:LHA RS13790
gene id: 449:LHA_RS13790
uniprot id: A0A0A8UWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

449:LHA RS02195
gene id: 449:LHA_RS02195
uniprot id: A0A0A8UPZ2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

449:LHA RS08865
gene id: 449:LHA_RS08865
uniprot id: A0A0A8UPZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane
messages: Membrane

449:LHA RS11225
gene id: 449:LHA_RS11225
uniprot id: A0A0A8UV73
names: Similarity
messages: Belongs to the P(II) protein family.

449:LHA RS08970
gene id: 449:LHA_RS08970
uniprot id: A0A0A8UQE2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

449:LHA RS10955
gene id: 449:LHA_RS10955
uniprot id: A0A0A8UX73
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

449:LHA RS03655
gene id: 449:LHA_RS03655
uniprot id: A0A0A8USU9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

449:LHA RS07210
gene id: 449:LHA_RS07210
uniprot id: A0A0A8UP22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

449:LHA RS03890
gene id: 449:LHA_RS03890
uniprot id: A0A0A8UQV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

449:LHA RS12870
gene id: 449:LHA_RS12870
uniprot id: A0A0A8USC1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

449:LHA RS10350
gene id: 449:LHA_RS10350
uniprot id: A0A0A8UVY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

449:LHA RS03270
gene id: 449:LHA_RS03270
uniprot id: A0A0A8USP1
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

449:LHA RS04445
gene id: 449:LHA_RS04445
uniprot id: A0A0A8UTD6
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS14275
gene id: 449:LHA_RS14275
uniprot id: A0A0A8UY50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

449:LHA RS15175
gene id: 449:LHA_RS15175
uniprot id: A0A0A8UU51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

449:LHA RS10855
gene id: 449:LHA_RS10855
uniprot id: A0A0A8UX54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS06775
gene id: 449:LHA_RS06775
uniprot id: A0A0A8UUP4
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS12510
gene id: 449:LHA_RS12510
uniprot id: A0A0A8UW08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

449:LHA RS03370
gene id: 449:LHA_RS03370
uniprot id: A0A0A8USQ4
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.

449:LHA RS10640
gene id: 449:LHA_RS10640
uniprot id: A0A0A8UW37
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

449:LHA RS11290
gene id: 449:LHA_RS11290
uniprot id: A0A0A8UXF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

449:LHA RS08735
gene id: 449:LHA_RS08735
uniprot id: A0A0A8UVV2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

449:LHA RS00330
gene id: 449:LHA_RS00330
uniprot id: A0A0A8UQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

449:LHA RS09255
gene id: 449:LHA_RS09255
uniprot id: A0A0A8UV81
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

449:LHA RS06680
gene id: 449:LHA_RS06680
uniprot id: A0A0A8UP04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

449:LHA RS12280
gene id: 449:LHA_RS12280
uniprot id: A0A0A8UX38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

449:LHA RS04105
gene id: 449:LHA_RS04105
uniprot id: A0A0A8UM59
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

449:LHA RS14220
gene id: 449:LHA_RS14220
uniprot id: A0A0A8UWY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS03000
gene id: 449:LHA_RS03000
uniprot id: A0A0A8ULX8
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS09780
gene id: 449:LHA_RS09780
uniprot id: A0A0A8UVN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

449:LHA RS06095
gene id: 449:LHA_RS06095
uniprot id: A0A0A8UNB2
names: Similarity
messages: Belongs to the AlaDH/PNT family.

449:LHA RS14575
gene id: 449:LHA_RS14575
uniprot id: A0A0A8UTV4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

449:LHA RS00030
gene id: 449:LHA_RS00030
uniprot id: A0A0A8UQX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

449:LHA RS03200
gene id: 449:LHA_RS03200
uniprot id: A0A0A8ULM6
names: Similarity
messages: Belongs to the YggT family.

449:LHA RS08890
gene id: 449:LHA_RS08890
uniprot id: A0A0A8UTT0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

449:LHA RS08475
gene id: 449:LHA_RS08475
uniprot id: A0A0A8UTK2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

449:LHA RS04610
gene id: 449:LHA_RS04610
uniprot id: A0A0A8UMH8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS00020
gene id: 449:LHA_RS00020
uniprot id: A0A0A8UNT0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

449:LHA RS00625
gene id: 449:LHA_RS00625
uniprot id: A0A0A8UR65
names: Similarity
messages: Belongs to the asparaginase 1 family.

449:LHA RS01535
gene id: 449:LHA_RS01535
uniprot id: A0A0A8UKP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

449:LHA RS16150
gene id: 449:LHA_RS16150
uniprot id: A0A0A8UR76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

449:LHA RS09080
gene id: 449:LHA_RS09080
uniprot id: A0A0A8UTX8
names: Similarity
messages: Belongs to the PhzF family.

449:LHA RS14330
gene id: 449:LHA_RS14330
uniprot id: A0A0A8UTL7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

449:LHA RS03670
gene id: 449:LHA_RS03670
uniprot id: A0A0A8URY9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

449:LHA RS00170
gene id: 449:LHA_RS00170
uniprot id: A0A0A8UKE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
messages: Cell membrane

449:LHA RS09025
gene id: 449:LHA_RS09025
uniprot id: A0A0A8UQ31
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS14895
gene id: 449:LHA_RS14895
uniprot id: A0A0A8UXE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

449:LHA RS14900
gene id: 449:LHA_RS14900
uniprot id: A0A0A8UYJ8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

449:LHA RS08915
gene id: 449:LHA_RS08915
uniprot id: A0A0A8UTT6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS02715
gene id: 449:LHA_RS02715
uniprot id: A0A0A8UQB1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

449:LHA RS08295
gene id: 449:LHA_RS08295
uniprot id: A0A0A8UPY5
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

449:LHA RS05160
gene id: 449:LHA_RS05160
uniprot id: A0A0A8UTV1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS06045
gene id: 449:LHA_RS06045
uniprot id: A0A0A8US48
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

449:LHA RS13905
gene id: 449:LHA_RS13905
uniprot id: A0A0A8UYZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

449:LHA RS01280
gene id: 449:LHA_RS01280
uniprot id: A0A0A8UQL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

449:LHA RS02855
gene id: 449:LHA_RS02855
uniprot id: A0A0A8ULV4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

449:LHA RS05590
gene id: 449:LHA_RS05590
uniprot id: A0A0A8UNE1
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.

449:LHA RS09530
gene id: 449:LHA_RS09530
uniprot id: A0A0A8UQS6
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS06005
gene id: 449:LHA_RS06005
uniprot id: A0A0A8UNK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

449:LHA RS11255
gene id: 449:LHA_RS11255
uniprot id: A0A0A8UWF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

449:LHA RS04050
gene id: 449:LHA_RS04050
uniprot id: A0A0A8UM42
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

449:LHA RS05610
gene id: 449:LHA_RS05610
uniprot id: A0A0A8UT54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

449:LHA RS12460
gene id: 449:LHA_RS12460
uniprot id: A0A0A8US63
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

449:LHA RS06220
gene id: 449:LHA_RS06220
uniprot id: A0A0A8US77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS09065
gene id: 449:LHA_RS09065
uniprot id: A0A0A8UQG4
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS01365
gene id: 449:LHA_RS01365
uniprot id: A0A0A8UKL5
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

449:LHA RS12825
gene id: 449:LHA_RS12825
uniprot id: A0A0A8UW55
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

449:LHA RS04475
gene id: 449:LHA_RS04475
uniprot id: A0A0A8USI0
names: Subcellular Location Annotation
messages: Cell inner membrane

449:LHA RS05090
gene id: 449:LHA_RS05090
uniprot id: A0A0A8UTU1
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

449:LHA RS09425
gene id: 449:LHA_RS09425
uniprot id: A0A0A8UVC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

449:LHA RS13945
gene id: 449:LHA_RS13945
uniprot id: A0A0A8UWS2
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

449:LHA RS08270
gene id: 449:LHA_RS08270
uniprot id: A0A0A8UUQ5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

449:LHA RS15325
gene id: 449:LHA_RS15325
uniprot id: A0A0A8UYS0
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

449:LHA RS13820
gene id: 449:LHA_RS13820
uniprot id: A0A0A8UXV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

449:LHA RS10520
gene id: 449:LHA_RS10520
uniprot id: A0A0A8UWZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

449:LHA RS13885
gene id: 449:LHA_RS13885
uniprot id: A0A0A8USY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

449:LHA RS12425
gene id: 449:LHA_RS12425
uniprot id: A0A0A8USI6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS01525
gene id: 449:LHA_RS01525
uniprot id: A0A0A8UL26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

449:LHA RS13740
gene id: 449:LHA_RS13740
uniprot id: A0A0A8USV3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

449:LHA RS08825
gene id: 449:LHA_RS08825
uniprot id: A0A0A8UV05
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS01805
gene id: 449:LHA_RS01805
uniprot id: A0A0A8UPQ5
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

449:LHA RS04685
gene id: 449:LHA_RS04685
uniprot id: A0A0A8USN9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

449:LHA RS06770
gene id: 449:LHA_RS06770
uniprot id: A0A0A8UP27
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

449:LHA RS06670
gene id: 449:LHA_RS06670
uniprot id: A0A0A8USI4
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

449:LHA RS00855
gene id: 449:LHA_RS00855
uniprot id: A0A0A8URA7
names: Similarity
messages: Belongs to the AHA1 family.

449:LHA RS01385
gene id: 449:LHA_RS01385
uniprot id: A0A0A8URL1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

449:LHA RS10215
gene id: 449:LHA_RS10215
uniprot id: A0A0A8UWT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

449:LHA RS13645
gene id: 449:LHA_RS13645
uniprot id: A0A0A8UST1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

449:LHA RS13815
gene id: 449:LHA_RS13815
uniprot id: A0A0A8UWP1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

449:LHA RS09525
gene id: 449:LHA_RS09525
uniprot id: A0A0A8UVF3
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

449:LHA RS12055
gene id: 449:LHA_RS12055
uniprot id: A0A0A8US08
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

449:LHA RS01550
gene id: 449:LHA_RS01550
uniprot id: A0A0A8UL32
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

449:LHA RS01670
gene id: 449:LHA_RS01670
uniprot id: A0A0A8UL60
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

449:LHA RS03320
gene id: 449:LHA_RS03320
uniprot id: A0A0A8UQJ9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

449:LHA RS01640
gene id: 449:LHA_RS01640
uniprot id: A0A0A8UPL0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

449:LHA RS03225
gene id: 449:LHA_RS03225
uniprot id: A0A0A8ULN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

449:LHA RS13670
gene id: 449:LHA_RS13670
uniprot id: A0A0A8UST6
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: The heme is bound between the two transmembrane subunits.

449:LHA RS07655
gene id: 449:LHA_RS07655
uniprot id: A0A0A8UUD6
names: Similarity
messages: Belongs to the peptidase S11 family.

449:LHA RS02595
gene id: 449:LHA_RS02595
uniprot id: A0A0A8UQ94
names: Similarity
messages: Belongs to the FrmR/RcnR family.

449:LHA RS12540
gene id: 449:LHA_RS12540
uniprot id: A0A0A8UX75
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

449:LHA RS15400
gene id: 449:LHA_RS15400
uniprot id: A0A0A8UU85
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

449:LHA RS09165
gene id: 449:LHA_RS09165
uniprot id: A0A0A8UQ67
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

449:LHA RS11310
gene id: 449:LHA_RS11310
uniprot id: A0A0A8URS1
names: Similarity
messages: Belongs to the SCO1/2 family.

449:LHA RS09925
gene id: 449:LHA_RS09925
uniprot id: A0A0A8UUI4
names: Similarity
messages: Belongs to the peptidase U62 family.

449:LHA RS01975
gene id: 449:LHA_RS01975
uniprot id: A0A0A8UPU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

449:LHA RS07825
gene id: 449:LHA_RS07825
uniprot id: A0A0A8UT89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

449:LHA RS10125
gene id: 449:LHA_RS10125
uniprot id: A0A0A8UUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

449:LHA RS10065
gene id: 449:LHA_RS10065
uniprot id: A0A0A8UQR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

449:LHA RS08385
gene id: 449:LHA_RS08385
uniprot id: A0A0A8UUS4
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

449:LHA RS11140
gene id: 449:LHA_RS11140
uniprot id: A0A0A8UXB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbI/VirB10 family.
messages: Membrane

449:LHA RS12595
gene id: 449:LHA_RS12595
uniprot id: A0A0A8UY80
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS04845
gene id: 449:LHA_RS04845
uniprot id: A0A0A8UN26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS03980
gene id: 449:LHA_RS03980
uniprot id: A0A0A8UM26
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

449:LHA RS00825
gene id: 449:LHA_RS00825
uniprot id: A0A0A8UKP4
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

449:LHA RS05985
gene id: 449:LHA_RS05985
uniprot id: A0A0A8UU84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

449:LHA RS04745
gene id: 449:LHA_RS04745
uniprot id: A0A0A8UMY2
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

449:LHA RS08790
gene id: 449:LHA_RS08790
uniprot id: A0A0A8UPX7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

449:LHA RS06690
gene id: 449:LHA_RS06690
uniprot id: A0A0A8USJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

449:LHA RS12420
gene id: 449:LHA_RS12420
uniprot id: A0A0A8UX58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

449:LHA RS02210
gene id: 449:LHA_RS02210
uniprot id: A0A0A8US45
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03945
gene id: 449:LHA_RS03945
uniprot id: A0A0A8UME3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

449:LHA RS15340
gene id: 449:LHA_RS15340
uniprot id: A0A0A8UTS6
names: Similarity
messages: Belongs to the AB hydrolase superfamily.

449:LHA RS01660
gene id: 449:LHA_RS01660
uniprot id: A0A0A8UPL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

449:LHA RS06685
gene id: 449:LHA_RS06685
uniprot id: A0A0A8UNN8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

449:LHA RS03955
gene id: 449:LHA_RS03955
uniprot id: A0A0A8UM21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

449:LHA RS03085
gene id: 449:LHA_RS03085
uniprot id: A0A0A8ULK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS05630
gene id: 449:LHA_RS05630
uniprot id: A0A0A8URX9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

449:LHA RS05065
gene id: 449:LHA_RS05065
uniprot id: A0A0A8UTT8
names: Subcellular Location Annotation
messages: Cytoplasm

449:LHA RS03895
gene id: 449:LHA_RS03895
uniprot id: A0A0A8US35
names: Similarity
messages: Belongs to the YkuD family.

449:LHA RS02025
gene id: 449:LHA_RS02025
uniprot id: A0A0A8UPV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS11050
gene id: 449:LHA_RS11050
uniprot id: A0A0A8UR88
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

449:LHA RS12695
gene id: 449:LHA_RS12695
uniprot id: A0A0A8US94
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

449:LHA RS07620
gene id: 449:LHA_RS07620
uniprot id: A0A0A8UPA1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS10385
gene id: 449:LHA_RS10385
uniprot id: A0A0A8UQV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

449:LHA RS09825
gene id: 449:LHA_RS09825
uniprot id: A0A0A8UUH1
names: Similarity
messages: Belongs to the archease family.

449:LHA RS03820
gene id: 449:LHA_RS03820
uniprot id: A0A0A8US18
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

449:LHA RS13345
gene id: 449:LHA_RS13345
uniprot id: A0A0A8USZ1
names: Similarity
messages: Belongs to the type III secretion exporter family.

449:LHA RS10655
gene id: 449:LHA_RS10655
uniprot id: A0A0A8UR04
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

449:LHA RS13805
gene id: 449:LHA_RS13805
uniprot id: A0A0A8UYX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

449:LHA RS02790
gene id: 449:LHA_RS02790
uniprot id: A0A0A8UQC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

449:LHA RS07660
gene id: 449:LHA_RS07660
uniprot id: A0A0A8UPM8
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

449:LHA RS13450
gene id: 449:LHA_RS13450
uniprot id: A0A0A8UWG4
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

449:LHA RS07175
gene id: 449:LHA_RS07175
uniprot id: A0A0A8UPC3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

449:LHA RS01360
gene id: 449:LHA_RS01360
uniprot id: A0A0A8URK5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

449:LHA RS08590
gene id: 449:LHA_RS08590
uniprot id: A0A0A8UPT6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

449:LHA RS02875
gene id: 449:LHA_RS02875
uniprot id: A0A0A8ULV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

449:LHA RS01655
gene id: 449:LHA_RS01655
uniprot id: A0A0A8UKS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

449:LHA RS07920
gene id: 449:LHA_RS07920
uniprot id: A0A0A8UVE9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

449:LHA RS02645
gene id: 449:LHA_RS02645
uniprot id: A0A0A8UQA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

449:LHA RS04630
gene id: 449:LHA_RS04630
uniprot id: A0A0A8UTH8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS11995
gene id: 449:LHA_RS11995
uniprot id: A0A0A8UWW4
names: Similarity
messages: Belongs to the YkuD family.

449:LHA RS11750
gene id: 449:LHA_RS11750
uniprot id: A0A0A8UVK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

449:LHA RS13480
gene id: 449:LHA_RS13480
uniprot id: A0A0A8UXN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

449:LHA RS14975
gene id: 449:LHA_RS14975
uniprot id: A0A0A8UU17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

449:LHA RS03240
gene id: 449:LHA_RS03240
uniprot id: A0A0A8UM17
names: Similarity
messages: Belongs to the RutC family.

449:LHA RS05365
gene id: 449:LHA_RS05365
uniprot id: A0A0A8UNA7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

449:LHA RS09930
gene id: 449:LHA_RS09930
uniprot id: A0A0A8UVR1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

449:LHA RS04130
gene id: 449:LHA_RS04130
uniprot id: A0A0A8UM66
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

449:LHA RS00575
gene id: 449:LHA_RS00575
uniprot id: A0A0A8UR57
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

449:LHA RS03550
gene id: 449:LHA_RS03550
uniprot id: A0A0A8URW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS09740
gene id: 449:LHA_RS09740
uniprot id: A0A0A8UWL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS07470
gene id: 449:LHA_RS07470
uniprot id: A0A0A8UPJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

449:LHA RS13975
gene id: 449:LHA_RS13975
uniprot id: A0A0A8UXY3
names: Similarity
messages: Belongs to the IucA/IucC family.

449:LHA RS13640
gene id: 449:LHA_RS13640
uniprot id: A0A0A8UYT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

449:LHA RS12530
gene id: 449:LHA_RS12530
uniprot id: A0A0A8US72
names: Similarity
messages: Belongs to the peptidase M16 family.

449:LHA RS07335
gene id: 449:LHA_RS07335
uniprot id: A0A0A8UT17
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

449:LHA RS03495
gene id: 449:LHA_RS03495
uniprot id: A0A0A8UQM4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

449:LHA RS01010
gene id: 449:LHA_RS01010
uniprot id: A0A0A8UP82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

449:LHA RS14085
gene id: 449:LHA_RS14085
uniprot id: A0A0A8UT36
names: Similarity
messages: Belongs to the CapA family.

449:LHA RS13875
gene id: 449:LHA_RS13875
uniprot id: A0A0A8UTB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

449:LHA RS05550
gene id: 449:LHA_RS05550
uniprot id: A0A0A8UN01
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

449:LHA RS06580
gene id: 449:LHA_RS06580
uniprot id: A0A0A8UNY0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

449:LHA RS06545
gene id: 449:LHA_RS06545
uniprot id: A0A0A8USE8
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

449:LHA RS07090
gene id: 449:LHA_RS07090
uniprot id: A0A0A8UPA5
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS13045
gene id: 449:LHA_RS13045
uniprot id: A0A0A8UXF1
names: Similarity
messages: Belongs to the WrbA family.

449:LHA RS05560
gene id: 449:LHA_RS05560
uniprot id: A0A0A8UT45
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

449:LHA RS01905
gene id: 449:LHA_RS01905
uniprot id: A0A0A8UPS9
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

449:LHA RS06825
gene id: 449:LHA_RS06825
uniprot id: A0A0A8UUQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

449:LHA RS01200
gene id: 449:LHA_RS01200
uniprot id: A0A0A8UPB9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

449:LHA RS09490
gene id: 449:LHA_RS09490
uniprot id: A0A0A8UQF2
names: Subcellular Location Annotation
messages: Cytoplasm

449:LHA RS09815
gene id: 449:LHA_RS09815
uniprot id: A0A0A8UWM7
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

449:LHA RS12875
gene id: 449:LHA_RS12875
uniprot id: A0A0A8UW64
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

449:LHA RS04325
gene id: 449:LHA_RS04325
uniprot id: A0A0A8UMA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

449:LHA RS01540
gene id: 449:LHA_RS01540
uniprot id: A0A0A8URM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

449:LHA RS12680
gene id: 449:LHA_RS12680
uniprot id: A0A0A8UX95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

449:LHA RS01945
gene id: 449:LHA_RS01945
uniprot id: A0A0A8UKY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

449:LHA RS14850
gene id: 449:LHA_RS14850
uniprot id: A0A0A8UYJ2
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

449:LHA RS13390
gene id: 449:LHA_RS13390
uniprot id: A0A0A8UT02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

449:LHA RS13780
gene id: 449:LHA_RS13780
uniprot id: A0A0A8UT92
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

449:LHA RS08950
gene id: 449:LHA_RS08950
uniprot id: A0A0A8UW12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

449:LHA RS00265
gene id: 449:LHA_RS00265
uniprot id: A0A0A8UKF9
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

449:LHA RS04240
gene id: 449:LHA_RS04240
uniprot id: A0A0A8UML3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS06915
gene id: 449:LHA_RS06915
uniprot id: A0A0A8UTW2
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS07255
gene id: 449:LHA_RS07255
uniprot id: A0A0A8UV24
names: Similarity
messages: Belongs to the YkuD family.

449:LHA RS09445
gene id: 449:LHA_RS09445
uniprot id: A0A0A8UU62
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

449:LHA RS14840
gene id: 449:LHA_RS14840
uniprot id: A0A0A8UTK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

449:LHA RS03840
gene id: 449:LHA_RS03840
uniprot id: A0A0A8UQU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

449:LHA RS08700
gene id: 449:LHA_RS08700
uniprot id: A0A0A8UUY6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

449:LHA RS15570
gene id: 449:LHA_RS15570
uniprot id: A0A0A8UYX1
names: Similarity
messages: Belongs to the peptidase S66 family.

449:LHA RS01590
gene id: 449:LHA_RS01590
uniprot id: A0A0A8UPJ7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

449:LHA RS09040
gene id: 449:LHA_RS09040
uniprot id: A0A0A8UQF7
names: Similarity
messages: Belongs to the YkuD family.

449:LHA RS00145
gene id: 449:LHA_RS00145
uniprot id: A0A0A8UKE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipid A palmitoyltransferase family.
messages: Cell outer membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.

449:LHA RS10310
gene id: 449:LHA_RS10310
uniprot id: A0A0A8UWV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

449:LHA RS03855
gene id: 449:LHA_RS03855
uniprot id: A0A0A8USZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

449:LHA RS08930
gene id: 449:LHA_RS08930
uniprot id: A0A0A8UQ07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

449:LHA RS07755
gene id: 449:LHA_RS07755
uniprot id: A0A0A8UUE9
names: Similarity
messages: Belongs to the RecJ family.

449:LHA RS08615
gene id: 449:LHA_RS08615
uniprot id: A0A0A8UPU1
names: Similarity
messages: Belongs to the PhoH family.

449:LHA RS12735
gene id: 449:LHA_RS12735
uniprot id: A0A0A8USN5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

449:LHA RS08960
gene id: 449:LHA_RS08960
uniprot id: A0A0A8UTU5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

449:LHA RS00975
gene id: 449:LHA_RS00975
uniprot id: A0A0A8URC7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

449:LHA RS06320
gene id: 449:LHA_RS06320
uniprot id: A0A0A8UTI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

449:LHA RS13465
gene id: 449:LHA_RS13465
uniprot id: A0A0A8UYP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

449:LHA RS14990
gene id: 449:LHA_RS14990
uniprot id: A0A0A8UXG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

449:LHA RS07910
gene id: 449:LHA_RS07910
uniprot id: A0A0A8UPR6
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS08785
gene id: 449:LHA_RS08785
uniprot id: A0A0A8UVW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS11320
gene id: 449:LHA_RS11320
uniprot id: A0A0A8URD9
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03380
gene id: 449:LHA_RS03380
uniprot id: A0A0A8UQK6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS10220
gene id: 449:LHA_RS10220
uniprot id: A0A0A8UQT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

449:LHA RS03235
gene id: 449:LHA_RS03235
uniprot id: A0A0A8URR9
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

449:LHA RS06840
gene id: 449:LHA_RS06840
uniprot id: A0A0A8UTU2
names: Similarity
messages: Belongs to the CFA/CMAS family.

449:LHA RS15085
gene id: 449:LHA_RS15085
uniprot id: A0A0A8UYN0
names: Similarity
messages: Belongs to the UPF0102 family.

449:LHA RS00045
gene id: 449:LHA_RS00045
uniprot id: A0A0A8UQ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

449:LHA RS08260
gene id: 449:LHA_RS08260
uniprot id: A0A0A8UPL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

449:LHA RS01170
gene id: 449:LHA_RS01170
uniprot id: A0A0A8UKH5
names: Similarity
messages: Belongs to the LOG family.

449:LHA RS12080
gene id: 449:LHA_RS12080
uniprot id: A0A0A8US12
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

449:LHA RS05755
gene id: 449:LHA_RS05755
uniprot id: A0A0A8URZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

449:LHA RS06565
gene id: 449:LHA_RS06565
uniprot id: A0A0A8UNK9
names: Similarity
messages: Belongs to the YkuD family.

449:LHA RS03715
gene id: 449:LHA_RS03715
uniprot id: A0A0A8UQR8
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS14435
gene id: 449:LHA_RS14435
uniprot id: A0A0A8UTN9
names: Subcellular Location Annotation
messages: Cytoplasm

449:LHA RS00075
gene id: 449:LHA_RS00075
uniprot id: A0A0A8UQX5
names: Similarity
messages: Belongs to the pirin family.

449:LHA RS09765
gene id: 449:LHA_RS09765
uniprot id: A0A0A8UWL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

449:LHA RS05660
gene id: 449:LHA_RS05660
uniprot id: A0A0A8UT63
names: Similarity
messages: Belongs to the glutathione peroxidase family.

449:LHA RS10230
gene id: 449:LHA_RS10230
uniprot id: A0A0A8UVW1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

449:LHA RS01015
gene id: 449:LHA_RS01015
uniprot id: A0A0A8UQH2
names: Similarity
messages: Belongs to the YciI family.

449:LHA RS07285
gene id: 449:LHA_RS07285
uniprot id: A0A0A8UT09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

449:LHA RS00805
gene id: 449:LHA_RS00805
uniprot id: A0A0A8UKP0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS03030
gene id: 449:LHA_RS03030
uniprot id: A0A0A8USK0
names: Similarity
messages: Belongs to the DSD1 family.

449:LHA RS03460
gene id: 449:LHA_RS03460
uniprot id: A0A0A8USR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

449:LHA RS03805
gene id: 449:LHA_RS03805
uniprot id: A0A0A8USY1
names: Similarity
messages: Belongs to the YkuD family.

449:LHA RS15665
gene id: 449:LHA_RS15665
uniprot id: A0A0A8UYZ4
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

449:LHA RS06505
gene id: 449:LHA_RS06505
uniprot id: A0A0A8UNW2
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.

449:LHA RS00295
gene id: 449:LHA_RS00295
uniprot id: A0A0A8UR09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

449:LHA RS03705
gene id: 449:LHA_RS03705
uniprot id: A0A0A8USW1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

449:LHA RS14610
gene id: 449:LHA_RS14610
uniprot id: A0A0A8UTH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

449:LHA RS09430
gene id: 449:LHA_RS09430
uniprot id: A0A0A8UQQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

449:LHA RS13610
gene id: 449:LHA_RS13610
uniprot id: A0A0A8UT52
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS11670
gene id: 449:LHA_RS11670
uniprot id: A0A0A8US05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

449:LHA RS12910
gene id: 449:LHA_RS12910
uniprot id: A0A0A8USR4
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

449:LHA RS06075
gene id: 449:LHA_RS06075
uniprot id: A0A0A8US53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

449:LHA RS08770
gene id: 449:LHA_RS08770
uniprot id: A0A0A8UTQ6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

449:LHA RS05490
gene id: 449:LHA_RS05490
uniprot id: A0A0A8UNC6
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS07770
gene id: 449:LHA_RS07770
uniprot id: A0A0A8UPC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

449:LHA RS13010
gene id: 449:LHA_RS13010
uniprot id: A0A0A8USE5
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS07275
gene id: 449:LHA_RS07275
uniprot id: A0A0A8UPG5
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

449:LHA RS08975
gene id: 449:LHA_RS08975
uniprot id: A0A0A8UW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

449:LHA RS07775
gene id: 449:LHA_RS07775
uniprot id: A0A0A8UT82
names: Similarity
messages: Belongs to the Nudix hydrolase family.

449:LHA RS10330
gene id: 449:LHA_RS10330
uniprot id: A0A0A8UR83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

449:LHA RS02090
gene id: 449:LHA_RS02090
uniprot id: A0A0A8US19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

449:LHA RS13925
gene id: 449:LHA_RS13925
uniprot id: A0A0A8UXX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

449:LHA RS16790
gene id: 449:LHA_RS16790
uniprot id: A0A0A8UU47
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

449:LHA RS13950
gene id: 449:LHA_RS13950
uniprot id: A0A0A8UXX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS10175
gene id: 449:LHA_RS10175
uniprot id: A0A0A8UUM8
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS00100
gene id: 449:LHA_RS00100
uniprot id: A0A0A8UQX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

449:LHA RS10425
gene id: 449:LHA_RS10425
uniprot id: A0A0A8UR98
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

449:LHA RS01270
gene id: 449:LHA_RS01270
uniprot id: A0A0A8UKJ7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

449:LHA RS00005
gene id: 449:LHA_RS00005
uniprot id: A0A0A8UKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

449:LHA RS08495
gene id: 449:LHA_RS08495
uniprot id: A0A0A8UPR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

449:LHA RS17335
gene id: 449:LHA_RS17335
uniprot id: A0A0A8UTY4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS06675
gene id: 449:LHA_RS06675
uniprot id: A0A0A8UTQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

449:LHA RS01970
gene id: 449:LHA_RS01970
uniprot id: A0A0A8UKZ5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

449:LHA RS01210
gene id: 449:LHA_RS01210
uniprot id: A0A0A8UKW6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

449:LHA RS13825
gene id: 449:LHA_RS13825
uniprot id: A0A0A8UTA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

449:LHA RS00435
gene id: 449:LHA_RS00435
uniprot id: A0A0A8UKI3
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

449:LHA RS00835
gene id: 449:LHA_RS00835
uniprot id: A0A0A8UKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

449:LHA RS01495
gene id: 449:LHA_RS01495
uniprot id: A0A0A8UQQ5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

449:LHA RS05225
gene id: 449:LHA_RS05225
uniprot id: A0A0A8URS0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

449:LHA RS04620
gene id: 449:LHA_RS04620
uniprot id: A0A0A8USM2
names: Similarity
messages: Belongs to the peptidase M13 family.

449:LHA RS13600
gene id: 449:LHA_RS13600
uniprot id: A0A0A8UWJ3
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

449:LHA RS04540
gene id: 449:LHA_RS04540
uniprot id: A0A0A8UMF8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

449:LHA RS14190
gene id: 449:LHA_RS14190
uniprot id: A0A0A8UWX8
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS13770
gene id: 449:LHA_RS13770
uniprot id: A0A0A8UWN1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS07435
gene id: 449:LHA_RS07435
uniprot id: A0A0A8UT33
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

449:LHA RS03695
gene id: 449:LHA_RS03695
uniprot id: A0A0A8URZ3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

449:LHA RS13455
gene id: 449:LHA_RS13455
uniprot id: A0A0A8UXN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

449:LHA RS07415
gene id: 449:LHA_RS07415
uniprot id: A0A0A8UUA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

449:LHA RS06490
gene id: 449:LHA_RS06490
uniprot id: A0A0A8UNJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

449:LHA RS11280
gene id: 449:LHA_RS11280
uniprot id: A0A0A8UWF5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

449:LHA RS06250
gene id: 449:LHA_RS06250
uniprot id: A0A0A8UNQ4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.

449:LHA RS08300
gene id: 449:LHA_RS08300
uniprot id: A0A0A8UVM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

449:LHA RS09455
gene id: 449:LHA_RS09455
uniprot id: A0A0A8UQQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

449:LHA RS01560
gene id: 449:LHA_RS01560
uniprot id: A0A0A8UKP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

449:LHA RS07295
gene id: 449:LHA_RS07295
uniprot id: A0A0A8UPG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

449:LHA RS04355
gene id: 449:LHA_RS04355
uniprot id: A0A0A8UR73
names: Similarity
messages: Belongs to the BolA/IbaG family.

449:LHA RS04075
gene id: 449:LHA_RS04075
uniprot id: A0A0A8UT48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

449:LHA RS02275
gene id: 449:LHA_RS02275
uniprot id: A0A0A8ULI9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

449:LHA RS00470
gene id: 449:LHA_RS00470
uniprot id: A0A0A8UK42
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

449:LHA RS08415
gene id: 449:LHA_RS08415
uniprot id: A0A0A8UVP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS04835
gene id: 449:LHA_RS04835
uniprot id: A0A0A8URL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

449:LHA RS01615
gene id: 449:LHA_RS01615
uniprot id: A0A0A8UPK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

449:LHA RS05995
gene id: 449:LHA_RS05995
uniprot id: A0A0A8US39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

449:LHA RS10590
gene id: 449:LHA_RS10590
uniprot id: A0A0A8UW28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

449:LHA RS10085
gene id: 449:LHA_RS10085
uniprot id: A0A0A8UR44
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

449:LHA RS05335
gene id: 449:LHA_RS05335
uniprot id: A0A0A8UT08
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

449:LHA RS07820
gene id: 449:LHA_RS07820
uniprot id: A0A0A8UPC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS06025
gene id: 449:LHA_RS06025
uniprot id: A0A0A8UTD0
names: Similarity
messages: Belongs to the peptidase S66 family.

449:LHA RS06610
gene id: 449:LHA_RS06610
uniprot id: A0A0A8UUL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

449:LHA RS06495
gene id: 449:LHA_RS06495
uniprot id: A0A0A8USD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

449:LHA RS10485
gene id: 449:LHA_RS10485
uniprot id: A0A0A8UW09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

449:LHA RS10020
gene id: 449:LHA_RS10020
uniprot id: A0A0A8UUK1
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

449:LHA RS12755
gene id: 449:LHA_RS12755
uniprot id: A0A0A8USP0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS01500
gene id: 449:LHA_RS01500
uniprot id: A0A0A8UL19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

449:LHA RS12720
gene id: 449:LHA_RS12720
uniprot id: A0A0A8US98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

449:LHA RS05545
gene id: 449:LHA_RS05545
uniprot id: A0A0A8UU16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

449:LHA RS04800
gene id: 449:LHA_RS04800
uniprot id: A0A0A8UTQ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

449:LHA RS12850
gene id: 449:LHA_RS12850
uniprot id: A0A0A8UW60
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS04270
gene id: 449:LHA_RS04270
uniprot id: A0A0A8UT97
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS04615
gene id: 449:LHA_RS04615
uniprot id: A0A0A8URD0
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

449:LHA RS09735
gene id: 449:LHA_RS09735
uniprot id: A0A0A8UQZ1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

449:LHA RS01855
gene id: 449:LHA_RS01855
uniprot id: A0A0A8UPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

449:LHA RS06245
gene id: 449:LHA_RS06245
uniprot id: A0A0A8UTH0
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

449:LHA RS11205
gene id: 449:LHA_RS11205
uniprot id: A0A0A8UWE1
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

449:LHA RS03645
gene id: 449:LHA_RS03645
uniprot id: A0A0A8URY5
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

449:LHA RS02690
gene id: 449:LHA_RS02690
uniprot id: A0A0A8ULF1
names: Subcellular Location Annotation
messages: Cytoplasm

449:LHA RS14055
gene id: 449:LHA_RS14055
uniprot id: A0A0A8UTF1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

449:LHA RS14960
gene id: 449:LHA_RS14960
uniprot id: A0A0A8UZL3
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS09795
gene id: 449:LHA_RS09795
uniprot id: A0A0A8UQM9
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

449:LHA RS01810
gene id: 449:LHA_RS01810
uniprot id: A0A0A8UQX4
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

449:LHA RS05685
gene id: 449:LHA_RS05685
uniprot id: A0A0A8UT69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

449:LHA RS08810
gene id: 449:LHA_RS08810
uniprot id: A0A0A8UVX3
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

449:LHA RS06595
gene id: 449:LHA_RS06595
uniprot id: A0A0A8USG3
names: Similarity
messages: Belongs to the cytochrome P450 family.

449:LHA RS04640
gene id: 449:LHA_RS04640
uniprot id: A0A0A8URD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

449:LHA RS01720
gene id: 449:LHA_RS01720
uniprot id: A0A0A8UL71
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

449:LHA RS02815
gene id: 449:LHA_RS02815
uniprot id: A0A0A8UQC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

449:LHA RS07510
gene id: 449:LHA_RS07510
uniprot id: A0A0A8UT44
names: Similarity
messages: Belongs to the PhzF family.

449:LHA RS08725
gene id: 449:LHA_RS08725
uniprot id: A0A0A8UUZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

449:LHA RS02615
gene id: 449:LHA_RS02615
uniprot id: A0A0A8ULD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

449:LHA RS10200
gene id: 449:LHA_RS10200
uniprot id: A0A0A8UUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

449:LHA RS07030
gene id: 449:LHA_RS07030
uniprot id: A0A0A8USS5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS14130
gene id: 449:LHA_RS14130
uniprot id: A0A0A8UZ43
names: Similarity
messages: Belongs to the UPF0229 family.

449:LHA RS03950
gene id: 449:LHA_RS03950
uniprot id: A0A0A8UT13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

449:LHA RS00520
gene id: 449:LHA_RS00520
uniprot id: A0A0A8UP02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

449:LHA RS03105
gene id: 449:LHA_RS03105
uniprot id: A0A0A8USL1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

449:LHA RS13810
gene id: 449:LHA_RS13810
uniprot id: A0A0A8USX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

449:LHA RS01275
gene id: 449:LHA_RS01275
uniprot id: A0A0A8UPD4
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

449:LHA RS05510
gene id: 449:LHA_RS05510
uniprot id: A0A0A8UT35
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS01685
gene id: 449:LHA_RS01685
uniprot id: A0A0A8UPM3
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

449:LHA RS04365
gene id: 449:LHA_RS04365
uniprot id: A0A0A8UMN7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

449:LHA RS04215
gene id: 449:LHA_RS04215
uniprot id: A0A0A8USB0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

449:LHA RS00815
gene id: 449:LHA_RS00815
uniprot id: A0A0A8UKA0
names: Similarity
messages: Belongs to the asparaginase 1 family.

449:LHA RS09470
gene id: 449:LHA_RS09470
uniprot id: A0A0A8UU68
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

449:LHA RS01920
gene id: 449:LHA_RS01920
uniprot id: A0A0A8UKY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

449:LHA RS10055
gene id: 449:LHA_RS10055
uniprot id: A0A0A8UR40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

449:LHA RS03635
gene id: 449:LHA_RS03635
uniprot id: A0A0A8ULV9
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

449:LHA RS05415
gene id: 449:LHA_RS05415
uniprot id: A0A0A8UNB4
names: Similarity
messages: Belongs to the HisA/HisF family.

449:LHA RS03585
gene id: 449:LHA_RS03585
uniprot id: A0A0A8UST4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

449:LHA RS04660
gene id: 449:LHA_RS04660
uniprot id: A0A0A8UMJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

449:LHA RS14225
gene id: 449:LHA_RS14225
uniprot id: A0A0A8UY37
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

449:LHA RS08905
gene id: 449:LHA_RS08905
uniprot id: A0A0A8UVZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

449:LHA RS00770
gene id: 449:LHA_RS00770
uniprot id: A0A0A8UP39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

449:LHA RS03990
gene id: 449:LHA_RS03990
uniprot id: A0A0A8US59
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS12375
gene id: 449:LHA_RS12375
uniprot id: A0A0A8USH9
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

449:LHA RS09410
gene id: 449:LHA_RS09410
uniprot id: A0A0A8UWC2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

449:LHA RS03230
gene id: 449:LHA_RS03230
uniprot id: A0A0A8UQI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

449:LHA RS01690
gene id: 449:LHA_RS01690
uniprot id: A0A0A8UQU6
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS12915
gene id: 449:LHA_RS12915
uniprot id: A0A0A8UYD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

449:LHA RS08900
gene id: 449:LHA_RS08900
uniprot id: A0A0A8UQC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

449:LHA RS13870
gene id: 449:LHA_RS13870
uniprot id: A0A0A8UXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

449:LHA RS09920
gene id: 449:LHA_RS09920
uniprot id: A0A0A8UQP4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS02670
gene id: 449:LHA_RS02670
uniprot id: A0A0A8UQA4
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

449:LHA RS06440
gene id: 449:LHA_RS06440
uniprot id: A0A0A8UNI1
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

449:LHA RS12505
gene id: 449:LHA_RS12505
uniprot id: A0A0A8US70
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

449:LHA RS01475
gene id: 449:LHA_RS01475
uniprot id: A0A0A8URM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

449:LHA RS07425
gene id: 449:LHA_RS07425
uniprot id: A0A0A8UV61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

449:LHA RS07180
gene id: 449:LHA_RS07180
uniprot id: A0A0A8UUX5
names: Similarity
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

449:LHA RS01790
gene id: 449:LHA_RS01790
uniprot id: A0A0A8UL84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS02625
gene id: 449:LHA_RS02625
uniprot id: A0A0A8URH4
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

449:LHA RS05305
gene id: 449:LHA_RS05305
uniprot id: A0A0A8UT03
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS04525
gene id: 449:LHA_RS04525
uniprot id: A0A0A8USJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

449:LHA RS01605
gene id: 449:LHA_RS01605
uniprot id: A0A0A8URQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

449:LHA RS00270
gene id: 449:LHA_RS00270
uniprot id: A0A0A8UR05
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

449:LHA RS01965
gene id: 449:LHA_RS01965
uniprot id: A0A0A8URZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

449:LHA RS03675
gene id: 449:LHA_RS03675
uniprot id: A0A0A8UM87
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

449:LHA RS12990
gene id: 449:LHA_RS12990
uniprot id: A0A0A8USE0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

449:LHA RS02780
gene id: 449:LHA_RS02780
uniprot id: A0A0A8USF8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

449:LHA RS07635
gene id: 449:LHA_RS07635
uniprot id: A0A0A8UPM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Membrane

449:LHA RS09380
gene id: 449:LHA_RS09380
uniprot id: A0A0A8UQN7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

449:LHA RS13545
gene id: 449:LHA_RS13545
uniprot id: A0A0A8UWI3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS07495
gene id: 449:LHA_RS07495
uniprot id: A0A0A8UPK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

449:LHA RS08575
gene id: 449:LHA_RS08575
uniprot id: A0A0A8UUW0
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

449:LHA RS08660
gene id: 449:LHA_RS08660
uniprot id: A0A0A8UVT8
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

449:LHA RS00780
gene id: 449:LHA_RS00780
uniprot id: A0A0A8UKN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Tetramer of two alpha and two beta subunits.

449:LHA RS11575
gene id: 449:LHA_RS11575
uniprot id: A0A0A8UWM1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

449:LHA RS13330
gene id: 449:LHA_RS13330
uniprot id: A0A0A8USL7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

449:LHA RS08505
gene id: 449:LHA_RS08505
uniprot id: A0A0A8UUU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

449:LHA RS14805
gene id: 449:LHA_RS14805
uniprot id: A0A0A8UXD6
names: Similarity
messages: Belongs to the peptidase C56 family.

449:LHA RS00955
gene id: 449:LHA_RS00955
uniprot id: A0A0A8URC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

449:LHA RS03930
gene id: 449:LHA_RS03930
uniprot id: A0A0A8UT05
names: Similarity
messages: Belongs to the peptidase M17 family.

449:LHA RS08285
gene id: 449:LHA_RS08285
uniprot id: A0A0A8UPL6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

449:LHA RS00345
gene id: 449:LHA_RS00345
uniprot id: A0A0A8UK25
names: Similarity
messages: Belongs to the TPP enzyme family.

449:LHA RS06085
gene id: 449:LHA_RS06085
uniprot id: A0A0A8UNM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

449:LHA RS08500
gene id: 449:LHA_RS08500
uniprot id: A0A0A8UTK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

449:LHA RS10535
gene id: 449:LHA_RS10535
uniprot id: A0A0A8UW19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

449:LHA RS07450
gene id: 449:LHA_RS07450
uniprot id: A0A0A8UV63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

449:LHA RS08685
gene id: 449:LHA_RS08685
uniprot id: A0A0A8UVU2
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

449:LHA RS02870
gene id: 449:LHA_RS02870
uniprot id: A0A0A8URK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

449:LHA RS12125
gene id: 449:LHA_RS12125
uniprot id: A0A0A8US17
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS01755
gene id: 449:LHA_RS01755
uniprot id: A0A0A8UPP1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

449:LHA RS06695
gene id: 449:LHA_RS06695
uniprot id: A0A0A8UTQ9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS09635
gene id: 449:LHA_RS09635
uniprot id: A0A0A8UQW5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

449:LHA RS05475
gene id: 449:LHA_RS05475
uniprot id: A0A0A8UMZ0
names: Similarity
messages: Belongs to the polysaccharide synthase family.

449:LHA RS13025
gene id: 449:LHA_RS13025
uniprot id: A0A0A8USS9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

449:LHA RS07220
gene id: 449:LHA_RS07220
uniprot id: A0A0A8UU40
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

449:LHA RS10525
gene id: 449:LHA_RS10525
uniprot id: A0A0A8UQX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

449:LHA RS14820
gene id: 449:LHA_RS14820
uniprot id: A0A0A8UXE0
names: Similarity
messages: Belongs to the UPF0145 family.

449:LHA RS13930
gene id: 449:LHA_RS13930
uniprot id: A0A0A8UTC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

449:LHA RS02060
gene id: 449:LHA_RS02060
uniprot id: A0A0A8ULE7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS08895
gene id: 449:LHA_RS08895
uniprot id: A0A0A8UV20
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

449:LHA RS03765
gene id: 449:LHA_RS03765
uniprot id: A0A0A8UQS7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

449:LHA RS01635
gene id: 449:LHA_RS01635
uniprot id: A0A0A8UKR5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

449:LHA RS13370
gene id: 449:LHA_RS13370
uniprot id: A0A0A8UYM9
names: Similarity
messages: Belongs to the peptidase S13 family.

449:LHA RS14540
gene id: 449:LHA_RS14540
uniprot id: A0A0A8UTG3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

449:LHA RS08450
gene id: 449:LHA_RS08450
uniprot id: A0A0A8UTJ7
names: Similarity
messages: Belongs to the acylphosphatase family.

449:LHA RS02040
gene id: 449:LHA_RS02040
uniprot id: A0A0A8US06
names: Similarity
messages: Belongs to the TPP enzyme family.

449:LHA RS06310
gene id: 449:LHA_RS06310
uniprot id: A0A0A8UNF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

449:LHA RS10050
gene id: 449:LHA_RS10050
uniprot id: A0A0A8UVS8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

449:LHA RS00865
gene id: 449:LHA_RS00865
uniprot id: A0A0A8UP55
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

449:LHA RS14530
gene id: 449:LHA_RS14530
uniprot id: A0A0A8UTU8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS10030
gene id: 449:LHA_RS10030
uniprot id: A0A0A8UR37
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

449:LHA RS09830
gene id: 449:LHA_RS09830
uniprot id: A0A0A8UVP4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

449:LHA RS00705
gene id: 449:LHA_RS00705
uniprot id: A0A0A8UP29
names: Similarity
messages: Belongs to the stealth family.

449:LHA RS13850
gene id: 449:LHA_RS13850
uniprot id: A0A0A8UTB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

449:LHA RS01570
gene id: 449:LHA_RS01570
uniprot id: A0A0A8UQS4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

449:LHA RS11885
gene id: 449:LHA_RS11885
uniprot id: A0A0A8UXU9
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

449:LHA RS09675
gene id: 449:LHA_RS09675
uniprot id: A0A0A8UUE8
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS10370
gene id: 449:LHA_RS10370
uniprot id: A0A0A8UVY7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

449:LHA RS03560
gene id: 449:LHA_RS03560
uniprot id: A0A0A8UST0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

449:LHA RS11105
gene id: 449:LHA_RS11105
uniprot id: A0A0A8UWB8
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03775
gene id: 449:LHA_RS03775
uniprot id: A0A0A8UMA7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

449:LHA RS13705
gene id: 449:LHA_RS13705
uniprot id: A0A0A8UT76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

449:LHA RS02950
gene id: 449:LHA_RS02950
uniprot id: A0A0A8ULX1
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

449:LHA RS10770
gene id: 449:LHA_RS10770
uniprot id: A0A0A8UW59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

449:LHA RS02830
gene id: 449:LHA_RS02830
uniprot id: A0A0A8USG6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS00035
gene id: 449:LHA_RS00035
uniprot id: A0A0A8UJY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

449:LHA RS07385
gene id: 449:LHA_RS07385
uniprot id: A0A0A8UT26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

449:LHA RS10035
gene id: 449:LHA_RS10035
uniprot id: A0A0A8UWQ6
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

449:LHA RS13985
gene id: 449:LHA_RS13985
uniprot id: A0A0A8UZ14
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03825
gene id: 449:LHA_RS03825
uniprot id: A0A0A8UMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

449:LHA RS14925
gene id: 449:LHA_RS14925
uniprot id: A0A0A8UU11
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

449:LHA RS03005
gene id: 449:LHA_RS03005
uniprot id: A0A0A8USJ6
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

449:LHA RS12955
gene id: 449:LHA_RS12955
uniprot id: A0A0A8USR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

449:LHA RS07185
gene id: 449:LHA_RS07185
uniprot id: A0A0A8UP16
names: Similarity
messages: Belongs to the YkuD family.

449:LHA RS06630
gene id: 449:LHA_RS06630
uniprot id: A0A0A8UNZ3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

449:LHA RS02265
gene id: 449:LHA_RS02265
uniprot id: A0A0A8UQ12
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS05670
gene id: 449:LHA_RS05670
uniprot id: A0A0A8UU35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

449:LHA RS00915
gene id: 449:LHA_RS00915
uniprot id: A0A0A8UP65
names: Subcellular Location Annotation
messages: Mitochondrion

449:LHA RS06430
gene id: 449:LHA_RS06430
uniprot id: A0A0A8UNU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

449:LHA RS03575
gene id: 449:LHA_RS03575
uniprot id: A0A0A8URX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

449:LHA RS12525
gene id: 449:LHA_RS12525
uniprot id: A0A0A8UY68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

449:LHA RS14765
gene id: 449:LHA_RS14765
uniprot id: A0A0A8UYH7
names: Similarity
messages: Belongs to the peptidase S24 family.

449:LHA RS03830
gene id: 449:LHA_RS03830
uniprot id: A0A0A8USY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

449:LHA RS14205
gene id: 449:LHA_RS14205
uniprot id: A0A0A8UTI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell inner membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

449:LHA RS06700
gene id: 449:LHA_RS06700
uniprot id: A0A0A8UP10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

449:LHA RS11590
gene id: 449:LHA_RS11590
uniprot id: A0A0A8URK8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

449:LHA RS08115
gene id: 449:LHA_RS08115
uniprot id: A0A0A8UPI5
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS05735
gene id: 449:LHA_RS05735
uniprot id: A0A0A8UT77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

449:LHA RS11665
gene id: 449:LHA_RS11665
uniprot id: A0A0A8UWN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS13910
gene id: 449:LHA_RS13910
uniprot id: A0A0A8USZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

449:LHA RS09640
gene id: 449:LHA_RS09640
uniprot id: A0A0A8UWK0
names: Subcellular Location Annotation
messages: Cell inner membrane

449:LHA RS01600
gene id: 449:LHA_RS01600
uniprot id: A0A0A8UL44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

449:LHA RS10885
gene id: 449:LHA_RS10885
uniprot id: A0A0A8UR52
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

449:LHA RS01650
gene id: 449:LHA_RS01650
uniprot id: A0A0A8UL55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

449:LHA RS04485
gene id: 449:LHA_RS04485
uniprot id: A0A0A8UTE0
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

449:LHA RS05815
gene id: 449:LHA_RS05815
uniprot id: A0A0A8US04
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS16815
gene id: 449:LHA_RS16815
uniprot id: A0A0A8URT1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

449:LHA RS10280
gene id: 449:LHA_RS10280
uniprot id: A0A0A8UR75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

449:LHA RS13955
gene id: 449:LHA_RS13955
uniprot id: A0A0A8UTD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

449:LHA RS09805
gene id: 449:LHA_RS09805
uniprot id: A0A0A8UVP0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS07245
gene id: 449:LHA_RS07245
uniprot id: A0A0A8UU63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell inner membrane
messages: Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP.
messages: Membrane

449:LHA RS02420
gene id: 449:LHA_RS02420
uniprot id: A0A0A8ULP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

449:LHA RS02665
gene id: 449:LHA_RS02665
uniprot id: A0A0A8ULE6
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

449:LHA RS12715
gene id: 449:LHA_RS12715
uniprot id: A0A0A8UYA1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

449:LHA RS01665
gene id: 449:LHA_RS01665
uniprot id: A0A0A8UQU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

449:LHA RS04335
gene id: 449:LHA_RS04335
uniprot id: A0A0A8USE3
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

449:LHA RS04655
gene id: 449:LHA_RS04655
uniprot id: A0A0A8UTI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

449:LHA RS05470
gene id: 449:LHA_RS05470
uniprot id: A0A0A8UU00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

449:LHA RS07460
gene id: 449:LHA_RS07460
uniprot id: A0A0A8UT37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS15760
gene id: 449:LHA_RS15760
uniprot id: A0A0A8UXU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TraA family.
messages: Cell inner membrane
messages: Membrane
messages: Monomer. Interacts with itself to form filaments; also interacts with TraQ.
messages: Secreted

449:LHA RS08360
gene id: 449:LHA_RS08360
uniprot id: A0A0A8UTH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

449:LHA RS03300
gene id: 449:LHA_RS03300
uniprot id: A0A0A8URS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

449:LHA RS08330
gene id: 449:LHA_RS08330
uniprot id: A0A0A8UPM7
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS09450
gene id: 449:LHA_RS09450
uniprot id: A0A0A8UVD5
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

449:LHA RS06500
gene id: 449:LHA_RS06500
uniprot id: A0A0A8UTM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

449:LHA RS09745
gene id: 449:LHA_RS09745
uniprot id: A0A0A8UQM2
names: Similarity
messages: Belongs to the BolA/IbaG family.

449:LHA RS06400
gene id: 449:LHA_RS06400
uniprot id: A0A0A8UNT8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS08220
gene id: 449:LHA_RS08220
uniprot id: A0A0A8UUP5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

449:LHA RS02865
gene id: 449:LHA_RS02865
uniprot id: A0A0A8UQD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

449:LHA RS07365
gene id: 449:LHA_RS07365
uniprot id: A0A0A8UU99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

449:LHA RS03760
gene id: 449:LHA_RS03760
uniprot id: A0A0A8ULY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS01090
gene id: 449:LHA_RS01090
uniprot id: A0A0A8UQI3
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS10875
gene id: 449:LHA_RS10875
uniprot id: A0A0A8URH5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

449:LHA RS05140
gene id: 449:LHA_RS05140
uniprot id: A0A0A8UMU9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

449:LHA RS02785
gene id: 449:LHA_RS02785
uniprot id: A0A0A8ULG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

449:LHA RS03090
gene id: 449:LHA_RS03090
uniprot id: A0A0A8UQG6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

449:LHA RS13895
gene id: 449:LHA_RS13895
uniprot id: A0A0A8UXW6
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

449:LHA RS03800
gene id: 449:LHA_RS03800
uniprot id: A0A0A8UMA9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

449:LHA RS15650
gene id: 449:LHA_RS15650
uniprot id: A0A0A8UUD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

449:LHA RS01725
gene id: 449:LHA_RS01725
uniprot id: A0A0A8URT5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

449:LHA RS12665
gene id: 449:LHA_RS12665
uniprot id: A0A0A8USM3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

449:LHA RS08755
gene id: 449:LHA_RS08755
uniprot id: A0A0A8UQ83
names: Similarity
messages: Belongs to the FGGY kinase family.

449:LHA RS09665
gene id: 449:LHA_RS09665
uniprot id: A0A0A8UWK4
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS03795
gene id: 449:LHA_RS03795
uniprot id: A0A0A8US13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

449:LHA RS02315
gene id: 449:LHA_RS02315
uniprot id: A0A0A8UQ43
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

449:LHA RS13470
gene id: 449:LHA_RS13470
uniprot id: A0A0A8USP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

449:LHA RS10675
gene id: 449:LHA_RS10675
uniprot id: A0A0A8UX24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

449:LHA RS01375
gene id: 449:LHA_RS01375
uniprot id: A0A0A8UQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

449:LHA RS12920
gene id: 449:LHA_RS12920
uniprot id: A0A0A8USD0
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

449:LHA RS01555
gene id: 449:LHA_RS01555
uniprot id: A0A0A8URP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

449:LHA RS11565
gene id: 449:LHA_RS11565
uniprot id: A0A0A8URK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

449:LHA RS11895
gene id: 449:LHA_RS11895
uniprot id: A0A0A8UVN0
names: Similarity
messages: Belongs to the UPF0166 family.

449:LHA RS09485
gene id: 449:LHA_RS09485
uniprot id: A0A0A8UWE6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS13035
gene id: 449:LHA_RS13035
uniprot id: A0A0A8USF0
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

449:LHA RS04125
gene id: 449:LHA_RS04125
uniprot id: A0A0A8UT61
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

449:LHA RS10775
gene id: 449:LHA_RS10775
uniprot id: A0A0A8URF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

449:LHA RS10205
gene id: 449:LHA_RS10205
uniprot id: A0A0A8UVV8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

449:LHA RS02710
gene id: 449:LHA_RS02710
uniprot id: A0A0A8USE6
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

449:LHA RS02990
gene id: 449:LHA_RS02990
uniprot id: A0A0A8UQF1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS13865
gene id: 449:LHA_RS13865
uniprot id: A0A0A8UWQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

449:LHA RS08805
gene id: 449:LHA_RS08805
uniprot id: A0A0A8UQ96
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

449:LHA RS13510
gene id: 449:LHA_RS13510
uniprot id: A0A0A8UYQ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

449:LHA RS10840
gene id: 449:LHA_RS10840
uniprot id: A0A0A8UUZ3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

449:LHA RS02750
gene id: 449:LHA_RS02750
uniprot id: A0A0A8ULU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

449:LHA RS08940
gene id: 449:LHA_RS08940
uniprot id: A0A0A8UV30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

449:LHA RS15690
gene id: 449:LHA_RS15690
uniprot id: A0A0A8UZ00
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS04850
gene id: 449:LHA_RS04850
uniprot id: A0A0A8UTR1
names: Cofactor
messages: Binds 1 FMN per subunit.

449:LHA RS08120
gene id: 449:LHA_RS08120
uniprot id: A0A0A8UTE2
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS12615
gene id: 449:LHA_RS12615
uniprot id: A0A0A8USL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

449:LHA RS10335
gene id: 449:LHA_RS10335
uniprot id: A0A0A8UWW1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

449:LHA RS03305
gene id: 449:LHA_RS03305
uniprot id: A0A0A8UM23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

449:LHA RS03700
gene id: 449:LHA_RS03700
uniprot id: A0A0A8UM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

449:LHA RS13460
gene id: 449:LHA_RS13460
uniprot id: A0A0A8UT16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

449:LHA RS08560
gene id: 449:LHA_RS08560
uniprot id: A0A0A8UQ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

449:LHA RS00950
gene id: 449:LHA_RS00950
uniprot id: A0A0A8UKR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

449:LHA RS09950
gene id: 449:LHA_RS09950
uniprot id: A0A0A8UVR4
names: Similarity
messages: Belongs to the DEAD box helicase family.

449:LHA RS05870
gene id: 449:LHA_RS05870
uniprot id: A0A0A8UTA2
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

449:LHA RS03020
gene id: 449:LHA_RS03020
uniprot id: A0A0A8URM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

449:LHA RS01515
gene id: 449:LHA_RS01515
uniprot id: A0A0A8UPH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

449:LHA RS08620
gene id: 449:LHA_RS08620
uniprot id: A0A0A8UTN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

449:LHA RS13075
gene id: 449:LHA_RS13075
uniprot id: A0A0A8UYG4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

449:LHA RS01530
gene id: 449:LHA_RS01530
uniprot id: A0A0A8URN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

449:LHA RS00545
gene id: 449:LHA_RS00545
uniprot id: A0A0A8UQ85
names: Similarity
messages: Belongs to the UPF0178 family.

449:LHA RS11495
gene id: 449:LHA_RS11495
uniprot id: A0A0A8URW7
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

449:LHA RS10260
gene id: 449:LHA_RS10260
uniprot id: A0A0A8UR71
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

449:LHA RS15095
gene id: 449:LHA_RS15095
uniprot id: A0A0A8UZN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

449:LHA RS02115
gene id: 449:LHA_RS02115
uniprot id: A0A0A8US25
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS01205
gene id: 449:LHA_RS01205
uniprot id: A0A0A8UQK2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

449:LHA RS12535
gene id: 449:LHA_RS12535
uniprot id: A0A0A8UW13
names: Similarity
messages: Belongs to the peptidase M16 family.

449:LHA RS03115
gene id: 449:LHA_RS03115
uniprot id: A0A0A8UQH0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

449:LHA RS10240
gene id: 449:LHA_RS10240
uniprot id: A0A0A8UWU3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS05840
gene id: 449:LHA_RS05840
uniprot id: A0A0A8US09
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS06510
gene id: 449:LHA_RS06510
uniprot id: A0A0A8UUI7
names: Subunit
messages: Homodimer.

449:LHA RS08720
gene id: 449:LHA_RS08720
uniprot id: A0A0A8UTP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

449:LHA RS07475
gene id: 449:LHA_RS07475
uniprot id: A0A0A8UV66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

449:LHA RS11315
gene id: 449:LHA_RS11315
uniprot id: A0A0A8UXG1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

449:LHA RS03100
gene id: 449:LHA_RS03100
uniprot id: A0A0A8ULZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

449:LHA RS03455
gene id: 449:LHA_RS03455
uniprot id: A0A0A8UM43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

449:LHA RS05760
gene id: 449:LHA_RS05760
uniprot id: A0A0A8UT83
names: Similarity
messages: Belongs to the ClpA/ClpB family.

449:LHA RS04425
gene id: 449:LHA_RS04425
uniprot id: A0A0A8UMD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

449:LHA RS06000
gene id: 449:LHA_RS06000
uniprot id: A0A0A8UTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS05805
gene id: 449:LHA_RS05805
uniprot id: A0A0A8UU58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

449:LHA RS08310
gene id: 449:LHA_RS08310
uniprot id: A0A0A8UTG9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

449:LHA RS09250
gene id: 449:LHA_RS09250
uniprot id: A0A0A8UU19
names: Similarity
messages: Belongs to the phosphohexose mutase family.

449:LHA RS08365
gene id: 449:LHA_RS08365
uniprot id: A0A0A8UUS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

449:LHA RS01260
gene id: 449:LHA_RS01260
uniprot id: A0A0A8UKX8
names: Similarity
messages: Belongs to the HIBADH-related family.

449:LHA RS08845
gene id: 449:LHA_RS08845
uniprot id: A0A0A8UTS0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

449:LHA RS07055
gene id: 449:LHA_RS07055
uniprot id: A0A0A8UST2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

449:LHA RS08485
gene id: 449:LHA_RS08485
uniprot id: A0A0A8UQ24
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

449:LHA RS13860
gene id: 449:LHA_RS13860
uniprot id: A0A0A8USY2
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS11620
gene id: 449:LHA_RS11620
uniprot id: A0A0A8UWN0
names: Subcellular Location Annotation
messages: Cytoplasm

449:LHA RS13515
gene id: 449:LHA_RS13515
uniprot id: A0A0A8USQ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

449:LHA RS05260
gene id: 449:LHA_RS05260
uniprot id: A0A0A8UN92
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS01580
gene id: 449:LHA_RS01580
uniprot id: A0A0A8URQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

449:LHA RS03485
gene id: 449:LHA_RS03485
uniprot id: A0A0A8USR9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS13020
gene id: 449:LHA_RS13020
uniprot id: A0A0A8UXE7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

449:LHA RS03420
gene id: 449:LHA_RS03420
uniprot id: A0A0A8UM38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

449:LHA RS10160
gene id: 449:LHA_RS10160
uniprot id: A0A0A8UR55
names: Similarity
messages: Belongs to the UDPGP type 2 family.

449:LHA RS14945
gene id: 449:LHA_RS14945
uniprot id: A0A0A8UXF7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

449:LHA RS09495
gene id: 449:LHA_RS09495
uniprot id: A0A0A8UU72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

449:LHA RS15685
gene id: 449:LHA_RS15685
uniprot id: A0A0A8UXT2
names: Similarity
messages: Belongs to the LOG family.

449:LHA RS08040
gene id: 449:LHA_RS08040
uniprot id: A0A0A8UPU8
names: Similarity
messages: Belongs to the acetyltransferase YopJ family.

449:LHA RS11570
gene id: 449:LHA_RS11570
uniprot id: A0A0A8UVG1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS09935
gene id: 449:LHA_RS09935
uniprot id: A0A0A8UR23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

449:LHA RS09270
gene id: 449:LHA_RS09270
uniprot id: A0A0A8UQ95
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

449:LHA RS01900
gene id: 449:LHA_RS01900
uniprot id: A0A0A8UKX5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS01955
gene id: 449:LHA_RS01955
uniprot id: A0A0A8UR13
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS06655
gene id: 449:LHA_RS06655
uniprot id: A0A0A8UNZ8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

449:LHA RS10605
gene id: 449:LHA_RS10605
uniprot id: A0A0A8UQZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

449:LHA RS05580
gene id: 449:LHA_RS05580
uniprot id: A0A0A8URX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

449:LHA RS10450
gene id: 449:LHA_RS10450
uniprot id: A0A0A8UQW4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS00945
gene id: 449:LHA_RS00945
uniprot id: A0A0A8UQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

449:LHA RS12685
gene id: 449:LHA_RS12685
uniprot id: A0A0A8USM8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS03595
gene id: 449:LHA_RS03595
uniprot id: A0A0A8URX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

449:LHA RS05290
gene id: 449:LHA_RS05290
uniprot id: A0A0A8UTX1
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

449:LHA RS05705
gene id: 449:LHA_RS05705
uniprot id: A0A0A8URY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS14595
gene id: 449:LHA_RS14595
uniprot id: A0A0A8UYF1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

449:LHA RS08540
gene id: 449:LHA_RS08540
uniprot id: A0A0A8UVR7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

449:LHA RS16810
gene id: 449:LHA_RS16810
uniprot id: A0A0A8UXT6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

449:LHA RS02525
gene id: 449:LHA_RS02525
uniprot id: A0A0A8URG2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

449:LHA RS00745
gene id: 449:LHA_RS00745
uniprot id: A0A0A8UK89
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

449:LHA RS10245
gene id: 449:LHA_RS10245
uniprot id: A0A0A8UQT4
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

449:LHA RS00150
gene id: 449:LHA_RS00150
uniprot id: A0A0A8UQY7
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS09870
gene id: 449:LHA_RS09870
uniprot id: A0A0A8UQN9
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS05285
gene id: 449:LHA_RS05285
uniprot id: A0A0A8UN95
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

449:LHA RS15000
gene id: 449:LHA_RS15000
uniprot id: A0A0A8UU22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

449:LHA RS13855
gene id: 449:LHA_RS13855
uniprot id: A0A0A8UYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

449:LHA RS14770
gene id: 449:LHA_RS14770
uniprot id: A0A0A8UTY3
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

449:LHA RS13405
gene id: 449:LHA_RS13405
uniprot id: A0A0A8UWF4
names: Similarity
messages: Belongs to the DprA/Smf family.

449:LHA RS09725
gene id: 449:LHA_RS09725
uniprot id: A0A0A8UUF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

449:LHA RS14910
gene id: 449:LHA_RS14910
uniprot id: A0A0A8UTL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

449:LHA RS14625
gene id: 449:LHA_RS14625
uniprot id: A0A0A8UTW1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

449:LHA RS04550
gene id: 449:LHA_RS04550
uniprot id: A0A0A8UMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

449:LHA RS13175
gene id: 449:LHA_RS13175
uniprot id: A0A0A8USW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

449:LHA RS14390
gene id: 449:LHA_RS14390
uniprot id: A0A0A8UZA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

449:LHA RS13215
gene id: 449:LHA_RS13215
uniprot id: A0A0A8UWB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

449:LHA RS12960
gene id: 449:LHA_RS12960
uniprot id: A0A0A8UYD7
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS11340
gene id: 449:LHA_RS11340
uniprot id: A0A0A8UXG6
names: Similarity
messages: Belongs to the GST superfamily.

449:LHA RS15180
gene id: 449:LHA_RS15180
uniprot id: A0A0A8UZQ1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

449:LHA RS14590
gene id: 449:LHA_RS14590
uniprot id: A0A0A8UXA1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

449:LHA RS10505
gene id: 449:LHA_RS10505
uniprot id: A0A0A8UUT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

449:LHA RS13180
gene id: 449:LHA_RS13180
uniprot id: A0A0A8UYJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

449:LHA RS01030
gene id: 449:LHA_RS01030
uniprot id: A0A0A8UKE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

449:LHA RS00990
gene id: 449:LHA_RS00990
uniprot id: A0A0A8UQG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

449:LHA RS07040
gene id: 449:LHA_RS07040
uniprot id: A0A0A8UP90
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

449:LHA RS10965
gene id: 449:LHA_RS10965
uniprot id: A0A0A8UV19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

449:LHA RS00460
gene id: 449:LHA_RS00460
uniprot id: A0A0A8UKI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS07615
gene id: 449:LHA_RS07615
uniprot id: A0A0A8UV89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

449:LHA RS01630
gene id: 449:LHA_RS01630
uniprot id: A0A0A8URR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

449:LHA RS13710
gene id: 449:LHA_RS13710
uniprot id: A0A0A8UYV3
names: Similarity
messages: Belongs to the FeoA family.

449:LHA RS00845
gene id: 449:LHA_RS00845
uniprot id: A0A0A8UQD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS10405
gene id: 449:LHA_RS10405
uniprot id: A0A0A8UWX5
names: Similarity
messages: Belongs to the peptidase U62 family.

449:LHA RS00790
gene id: 449:LHA_RS00790
uniprot id: A0A0A8UK97
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

449:LHA RS09810
gene id: 449:LHA_RS09810
uniprot id: A0A0A8UR03
names: Similarity
messages: Belongs to the TrpC family.

449:LHA RS00250
gene id: 449:LHA_RS00250
uniprot id: A0A0A8UK11
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

449:LHA RS13200
gene id: 449:LHA_RS13200
uniprot id: A0A0A8USW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

449:LHA RS07300
gene id: 449:LHA_RS07300
uniprot id: A0A0A8UV36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

449:LHA RS13190
gene id: 449:LHA_RS13190
uniprot id: A0A0A8UWB1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

449:LHA RS07650
gene id: 449:LHA_RS07650
uniprot id: A0A0A8UT64
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

449:LHA RS09360
gene id: 449:LHA_RS09360
uniprot id: A0A0A8UWA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

449:LHA RS03720
gene id: 449:LHA_RS03720
uniprot id: A0A0A8URZ8
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

449:LHA RS01820
gene id: 449:LHA_RS01820
uniprot id: A0A0A8URW0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

449:LHA RS01485
gene id: 449:LHA_RS01485
uniprot id: A0A0A8UKM8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS07190
gene id: 449:LHA_RS07190
uniprot id: A0A0A8USW6
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS09855
gene id: 449:LHA_RS09855
uniprot id: A0A0A8UVP7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

449:LHA RS04900
gene id: 449:LHA_RS04900
uniprot id: A0A0A8URM2
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

449:LHA RS11305
gene id: 449:LHA_RS11305
uniprot id: A0A0A8UWG1
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

449:LHA RS05565
gene id: 449:LHA_RS05565
uniprot id: A0A0A8UND9
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS08535
gene id: 449:LHA_RS08535
uniprot id: A0A0A8UQ34
names: Function
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.
messages: Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

449:LHA RS06415
gene id: 449:LHA_RS06415
uniprot id: A0A0A8USB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

449:LHA RS12135
gene id: 449:LHA_RS12135
uniprot id: A0A0A8UX13
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

449:LHA RS15220
gene id: 449:LHA_RS15220
uniprot id: A0A0A8UTQ5
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

449:LHA RS10595
gene id: 449:LHA_RS10595
uniprot id: A0A0A8URC4
names: Similarity
messages: Belongs to the aspartokinase family.

449:LHA RS11100
gene id: 449:LHA_RS11100
uniprot id: A0A0A8UR97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane

449:LHA RS01625
gene id: 449:LHA_RS01625
uniprot id: A0A0A8UL49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

449:LHA RS07490
gene id: 449:LHA_RS07490
uniprot id: A0A0A8UUB3
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS02520
gene id: 449:LHA_RS02520
uniprot id: A0A0A8UQ84
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

449:LHA RS05690
gene id: 449:LHA_RS05690
uniprot id: A0A0A8UNF7
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

449:LHA RS11765
gene id: 449:LHA_RS11765
uniprot id: A0A0A8UXR6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

449:LHA RS08920
gene id: 449:LHA_RS08920
uniprot id: A0A0A8UV25
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS00010
gene id: 449:LHA_RS00010
uniprot id: A0A0A8UQW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

449:LHA RS09995
gene id: 449:LHA_RS09995
uniprot id: A0A0A8UUJ7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

449:LHA RS10985
gene id: 449:LHA_RS10985
uniprot id: A0A0A8UR72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

449:LHA RS06945
gene id: 449:LHA_RS06945
uniprot id: A0A0A8UP63
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

449:LHA RS12980
gene id: 449:LHA_RS12980
uniprot id: A0A0A8USS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell.

449:LHA RS03205
gene id: 449:LHA_RS03205
uniprot id: A0A0A8UQI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

449:LHA RS06315
gene id: 449:LHA_RS06315
uniprot id: A0A0A8US97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

449:LHA RS02535
gene id: 449:LHA_RS02535
uniprot id: A0A0A8USC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

449:LHA RS03015
gene id: 449:LHA_RS03015
uniprot id: A0A0A8UQF5
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

449:LHA RS06590
gene id: 449:LHA_RS06590
uniprot id: A0A0A8UNL5
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS15370
gene id: 449:LHA_RS15370
uniprot id: A0A0A8UYT0
names: Cofactor
messages: Binds 1 FMN per subunit.

449:LHA RS01140
gene id: 449:LHA_RS01140
uniprot id: A0A0A8UQJ1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

449:LHA RS05210
gene id: 449:LHA_RS05210
uniprot id: A0A0A8UTW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

449:LHA RS02985
gene id: 449:LHA_RS02985
uniprot id: A0A0A8ULJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

449:LHA RS01995
gene id: 449:LHA_RS01995
uniprot id: A0A0A8UL03
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

449:LHA RS14915
gene id: 449:LHA_RS14915
uniprot id: A0A0A8UXF3
names: Similarity
messages: Belongs to the thioredoxin family.

449:LHA RS01510
gene id: 449:LHA_RS01510
uniprot id: A0A0A8UKN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

449:LHA RS14295
gene id: 449:LHA_RS14295
uniprot id: A0A0A8UX01
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

449:LHA RS02725
gene id: 449:LHA_RS02725
uniprot id: A0A0A8ULT6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS00885
gene id: 449:LHA_RS00885
uniprot id: A0A0A8UKB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

449:LHA RS05200
gene id: 449:LHA_RS05200
uniprot id: A0A0A8USZ2
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

449:LHA RS13800
gene id: 449:LHA_RS13800
uniprot id: A0A0A8UT98
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

449:LHA RS02355
gene id: 449:LHA_RS02355
uniprot id: A0A0A8USA0
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS13415
gene id: 449:LHA_RS13415
uniprot id: A0A0A8UT06
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

449:LHA RS09435
gene id: 449:LHA_RS09435
uniprot id: A0A0A8UWD0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

449:LHA RS08760
gene id: 449:LHA_RS08760
uniprot id: A0A0A8UVV9
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

449:LHA RS03975
gene id: 449:LHA_RS03975
uniprot id: A0A0A8UT19
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS13220
gene id: 449:LHA_RS13220
uniprot id: A0A0A8UXI6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

449:LHA RS13835
gene id: 449:LHA_RS13835
uniprot id: A0A0A8USX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

449:LHA RS04450
gene id: 449:LHA_RS04450
uniprot id: A0A0A8UMD9
names: Similarity
messages: Belongs to the DDAH family.

449:LHA RS08715
gene id: 449:LHA_RS08715
uniprot id: A0A0A8UPW2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

449:LHA RS13665
gene id: 449:LHA_RS13665
uniprot id: A0A0A8UYU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

449:LHA RS13195
gene id: 449:LHA_RS13195
uniprot id: A0A0A8UXI1
names: Similarity
messages: Belongs to the Fur family.

449:LHA RS07540
gene id: 449:LHA_RS07540
uniprot id: A0A0A8UUB9
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

449:LHA RS00160
gene id: 449:LHA_RS00160
uniprot id: A0A0A8UNV0
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS10250
gene id: 449:LHA_RS10250
uniprot id: A0A0A8UUP2
names: Similarity
messages: Belongs to the HesB/IscA family.

449:LHA RS02350
gene id: 449:LHA_RS02350
uniprot id: A0A0A8ULM8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

449:LHA RS11260
gene id: 449:LHA_RS11260
uniprot id: A0A0A8URR0
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

449:LHA RS06640
gene id: 449:LHA_RS06640
uniprot id: A0A0A8UNM7
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

449:LHA RS13550
gene id: 449:LHA_RS13550
uniprot id: A0A0A8UXP6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS15105
gene id: 449:LHA_RS15105
uniprot id: A0A0A8UU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.
messages: Cell inner membrane
messages: Membrane

449:LHA RS04120
gene id: 449:LHA_RS04120
uniprot id: A0A0A8UMI7
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

449:LHA RS07725
gene id: 449:LHA_RS07725
uniprot id: A0A0A8UT74
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

449:LHA RS02085
gene id: 449:LHA_RS02085
uniprot id: A0A0A8ULF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

449:LHA RS10155
gene id: 449:LHA_RS10155
uniprot id: A0A0A8UVU9
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

449:LHA RS11245
gene id: 449:LHA_RS11245
uniprot id: A0A0A8URC5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

449:LHA RS04515
gene id: 449:LHA_RS04515
uniprot id: A0A0A8UMF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

449:LHA RS06090
gene id: 449:LHA_RS06090
uniprot id: A0A0A8UUA2
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

449:LHA RS05980
gene id: 449:LHA_RS05980
uniprot id: A0A0A8UNK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

449:LHA RS01215
gene id: 449:LHA_RS01215
uniprot id: A0A0A8URH7
names: Similarity
messages: Belongs to the pyruvate kinase family.

449:LHA RS13980
gene id: 449:LHA_RS13980
uniprot id: A0A0A8UTD7
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS12670
gene id: 449:LHA_RS12670
uniprot id: A0A0A8UY94
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

449:LHA RS04375
gene id: 449:LHA_RS04375
uniprot id: A0A0A8UR80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

449:LHA RS06660
gene id: 449:LHA_RS06660
uniprot id: A0A0A8UUM0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

449:LHA RS09010
gene id: 449:LHA_RS09010
uniprot id: A0A0A8UTV8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

449:LHA RS02740
gene id: 449:LHA_RS02740
uniprot id: A0A0A8UQB4
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

449:LHA RS14760
gene id: 449:LHA_RS14760
uniprot id: A0A0A8UXC9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

449:LHA RS09045
gene id: 449:LHA_RS09045
uniprot id: A0A0A8UW35
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

449:LHA RS05340
gene id: 449:LHA_RS05340
uniprot id: A0A0A8UNA3
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

449:LHA RS02685
gene id: 449:LHA_RS02685
uniprot id: A0A0A8USE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

449:LHA RS02880
gene id: 449:LHA_RS02880
uniprot id: A0A0A8USH4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

449:LHA RS02550
gene id: 449:LHA_RS02550
uniprot id: A0A0A8URG6
names: Subcellular Location Annotation
messages: Nucleus

449:LHA RS03880
gene id: 449:LHA_RS03880
uniprot id: A0A0A8USZ5
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

449:LHA RS13940
gene id: 449:LHA_RS13940
uniprot id: A0A0A8USZ9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

449:LHA RS01370
gene id: 449:LHA_RS01370
uniprot id: A0A0A8UPE7
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

449:LHA RS10390
gene id: 449:LHA_RS10390
uniprot id: A0A0A8UUR7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

449:LHA RS07585
gene id: 449:LHA_RS07585
uniprot id: A0A0A8UPL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

449:LHA RS10000
gene id: 449:LHA_RS10000
uniprot id: A0A0A8UVS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

449:LHA RS11835
gene id: 449:LHA_RS11835
uniprot id: A0A0A8US49
names: Similarity
messages: Belongs to the Gfa family.

449:LHA RS01595
gene id: 449:LHA_RS01595
uniprot id: A0A0A8UQS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

449:LHA RS08655
gene id: 449:LHA_RS08655
uniprot id: A0A0A8UQ60
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

449:LHA RS13475
gene id: 449:LHA_RS13475
uniprot id: A0A0A8UWG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

449:LHA RS13565
gene id: 449:LHA_RS13565
uniprot id: A0A0A8USR7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

449:LHA RS01290
gene id: 449:LHA_RS01290
uniprot id: A0A0A8URJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

449:LHA RS13735
gene id: 449:LHA_RS13735
uniprot id: A0A0A8UYV9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

449:LHA RS14215
gene id: 449:LHA_RS14215
uniprot id: A0A0A8UT68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

449:LHA RS13205
gene id: 449:LHA_RS13205
uniprot id: A0A0A8UYJ3
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS10835
gene id: 449:LHA_RS10835
uniprot id: A0A0A8UR42
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

449:LHA RS00755
gene id: 449:LHA_RS00755
uniprot id: A0A0A8UQC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

449:LHA RS03770
gene id: 449:LHA_RS03770
uniprot id: A0A0A8US07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Membrane

449:LHA RS04650
gene id: 449:LHA_RS04650
uniprot id: A0A0A8UMV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

449:LHA RS03600
gene id: 449:LHA_RS03600
uniprot id: A0A0A8UM72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

449:LHA RS04815
gene id: 449:LHA_RS04815
uniprot id: A0A0A8UST8
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

449:LHA RS01340
gene id: 449:LHA_RS01340
uniprot id: A0A0A8UKL0
names: Similarity
messages: Belongs to the UPF0234 family.

449:LHA RS01565
gene id: 449:LHA_RS01565
uniprot id: A0A0A8UPI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

449:LHA RS08255
gene id: 449:LHA_RS08255
uniprot id: A0A0A8UVL2
names: Similarity
messages: Belongs to the fabD family.

449:LHA RS09205
gene id: 449:LHA_RS09205
uniprot id: A0A0A8UQJ5
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

449:LHA RS02620
gene id: 449:LHA_RS02620
uniprot id: A0A0A8UQ98
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

449:LHA RS07805
gene id: 449:LHA_RS07805
uniprot id: A0A0A8UUF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

449:LHA RS01585
gene id: 449:LHA_RS01585
uniprot id: A0A0A8UKQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

449:LHA RS01610
gene id: 449:LHA_RS01610
uniprot id: A0A0A8UKQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

449:LHA RS14995
gene id: 449:LHA_RS14995
uniprot id: A0A0A8UYL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

449:LHA RS07730
gene id: 449:LHA_RS07730
uniprot id: A0A0A8UUE6
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

449:LHA RS06570
gene id: 449:LHA_RS06570
uniprot id: A0A0A8USF5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

449:LHA RS03355
gene id: 449:LHA_RS03355
uniprot id: A0A0A8UQK3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

449:LHA RS04830
gene id: 449:LHA_RS04830
uniprot id: A0A0A8UMQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

449:LHA RS08690
gene id: 449:LHA_RS08690
uniprot id: A0A0A8UPV7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS12340
gene id: 449:LHA_RS12340
uniprot id: A0A0A8US47
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS02145
gene id: 449:LHA_RS02145
uniprot id: A0A0A8UL41
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

449:LHA RS10600
gene id: 449:LHA_RS10600
uniprot id: A0A0A8UX09
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

449:LHA RS01410
gene id: 449:LHA_RS01410
uniprot id: A0A0A8URL7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

449:LHA RS06325
gene id: 449:LHA_RS06325
uniprot id: A0A0A8UNS1
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS07420
gene id: 449:LHA_RS07420
uniprot id: A0A0A8UPJ0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

449:LHA RS12110
gene id: 449:LHA_RS12110
uniprot id: A0A0A8UVV5
names: Subcellular Location Annotation
messages: Membrane

449:LHA RS12705
gene id: 449:LHA_RS12705
uniprot id: A0A0A8UXA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

449:LHA RS10315
gene id: 449:LHA_RS10315
uniprot id: A0A0A8UQU4
names: Subcellular Location Annotation
messages: Cytoplasm

449:LHA RS05125
gene id: 449:LHA_RS05125
uniprot id: A0A0A8USY3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

449:LHA RS02935
gene id: 449:LHA_RS02935
uniprot id: A0A0A8ULI4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

449:LHA RS08280
gene id: 449:LHA_RS08280
uniprot id: A0A0A8UVL7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

449:LHA RS02900
gene id: 449:LHA_RS02900
uniprot id: A0A0A8ULW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

449:LHA RS12440
gene id: 449:LHA_RS12440
uniprot id: A0A0A8UVZ8
names: Similarity
messages: Belongs to the YjdM family.

449:LHA RS13505
gene id: 449:LHA_RS13505
uniprot id: A0A0A8UT28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.

449:LHA RS03465
gene id: 449:LHA_RS03465
uniprot id: A0A0A8ULS2
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

449:LHA RS04285
gene id: 449:LHA_RS04285
uniprot id: A0A0A8USC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

449:LHA RS04905
gene id: 449:LHA_RS04905
uniprot id: A0A0A8USV1
names: Similarity
messages: Belongs to the peptidase S24 family.

449:LHA RS13595
gene id: 449:LHA_RS13595
uniprot id: A0A0A8USS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).