446466:CFLA RS05320
gene id: 446466:CFLA_RS05320
uniprot id: D5ULB9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

446466:CFLA RS17400
gene id: 446466:CFLA_RS17400
uniprot id: D5UCU5
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

446466:CFLA RS04115
gene id: 446466:CFLA_RS04115
uniprot id: D5UJY6
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS02245
gene id: 446466:CFLA_RS02245
uniprot id: D5UHT7
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

446466:CFLA RS09310
gene id: 446466:CFLA_RS09310
uniprot id: D5UES6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

446466:CFLA RS08315
gene id: 446466:CFLA_RS08315
uniprot id: D5UDY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

446466:CFLA RS13185
gene id: 446466:CFLA_RS13185
uniprot id: D5UIT3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

446466:CFLA RS03150
gene id: 446466:CFLA_RS03150
uniprot id: D5UIN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

446466:CFLA RS14475
gene id: 446466:CFLA_RS14475
uniprot id: D5UK87
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13390
gene id: 446466:CFLA_RS13390
uniprot id: D5UIX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

446466:CFLA RS10040
gene id: 446466:CFLA_RS10040
uniprot id: D5UF81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

446466:CFLA RS05650
gene id: 446466:CFLA_RS05650
uniprot id: D5ULI0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

446466:CFLA RS08005
gene id: 446466:CFLA_RS08005
uniprot id: D5UDS7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

446466:CFLA RS05370
gene id: 446466:CFLA_RS05370
uniprot id: D5ULC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

446466:CFLA RS13585
gene id: 446466:CFLA_RS13585
uniprot id: D5UJ09
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09420
gene id: 446466:CFLA_RS09420
uniprot id: D5UEU8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

446466:CFLA RS13435
gene id: 446466:CFLA_RS13435
uniprot id: D5UIY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

446466:CFLA RS05415
gene id: 446466:CFLA_RS05415
uniprot id: D5ULD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

446466:CFLA RS01140
gene id: 446466:CFLA_RS01140
uniprot id: D5UGG2
names: Similarity
messages: Belongs to the YciI family.

446466:CFLA RS03080
gene id: 446466:CFLA_RS03080
uniprot id: D5UIM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

446466:CFLA RS09160
gene id: 446466:CFLA_RS09160
uniprot id: D5UEP8
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS14360
gene id: 446466:CFLA_RS14360
uniprot id: D5UJT7
names: Similarity
messages: Belongs to the YciI family.

446466:CFLA RS12650
gene id: 446466:CFLA_RS12650
uniprot id: D5UI47
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS08075
gene id: 446466:CFLA_RS08075
uniprot id: D5UDU1
names: Similarity
messages: Belongs to the YggT family.

446466:CFLA RS16110
gene id: 446466:CFLA_RS16110
uniprot id: D5ULW7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

446466:CFLA RS16145
gene id: 446466:CFLA_RS16145
uniprot id: D5ULX4
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

446466:CFLA RS01050
gene id: 446466:CFLA_RS01050
uniprot id: D5UGE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

446466:CFLA RS17320
gene id: 446466:CFLA_RS17320
uniprot id: D5UCS8
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

446466:CFLA RS05380
gene id: 446466:CFLA_RS05380
uniprot id: D5ULD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

446466:CFLA RS18060
gene id: 446466:CFLA_RS18060
uniprot id: D5UDK3
names: Function
names: Similarity
messages: Belongs to the Stf0 sulfotransferase family.
messages: Catalyzes the sulfuryl group transfer from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to trehalose, leading to trehalose-2-sulfate (T2S).

446466:CFLA RS09200
gene id: 446466:CFLA_RS09200
uniprot id: D5UEQ5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

446466:CFLA RS13845
gene id: 446466:CFLA_RS13845
uniprot id: D5UJI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

446466:CFLA RS09710
gene id: 446466:CFLA_RS09710
uniprot id: D5UF06
names: Similarity
messages: Belongs to the universal stress protein A family.

446466:CFLA RS12790
gene id: 446466:CFLA_RS12790
uniprot id: D5UI75
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

446466:CFLA RS02135
gene id: 446466:CFLA_RS02135
uniprot id: D5UHR5
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

446466:CFLA RS10385
gene id: 446466:CFLA_RS10385
uniprot id: D5UFE9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

446466:CFLA RS13275
gene id: 446466:CFLA_RS13275
uniprot id: D5UIV0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

446466:CFLA RS11090
gene id: 446466:CFLA_RS11090
uniprot id: D5UG58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

446466:CFLA RS08240
gene id: 446466:CFLA_RS08240
uniprot id: D5UDX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

446466:CFLA RS02790
gene id: 446466:CFLA_RS02790
uniprot id: D5UIG7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446466:CFLA RS10345
gene id: 446466:CFLA_RS10345
uniprot id: D5UFE1
names: Similarity
messages: Belongs to the UPF0098 family.

446466:CFLA RS08245
gene id: 446466:CFLA_RS08245
uniprot id: D5UDX4
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

446466:CFLA RS01265
gene id: 446466:CFLA_RS01265
uniprot id: D5UGI6
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS15325
gene id: 446466:CFLA_RS15325
uniprot id: D5UL33
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

446466:CFLA RS18585
gene id: 446466:CFLA_RS18585
uniprot id: D5UE89
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

446466:CFLA RS09890
gene id: 446466:CFLA_RS09890
uniprot id: D5UF51
names: Similarity
messages: Belongs to the YciI family.

446466:CFLA RS12000
gene id: 446466:CFLA_RS12000
uniprot id: D5UHE1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

446466:CFLA RS16950
gene id: 446466:CFLA_RS16950
uniprot id: D5UC84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS11215
gene id: 446466:CFLA_RS11215
uniprot id: D5UGK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

446466:CFLA RS07705
gene id: 446466:CFLA_RS07705
uniprot id: D5UD87
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446466:CFLA RS05210
gene id: 446466:CFLA_RS05210
uniprot id: D5UKX3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

446466:CFLA RS18725
gene id: 446466:CFLA_RS18725
uniprot id: D5UEC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

446466:CFLA RS15005
gene id: 446466:CFLA_RS15005
uniprot id: D5UKJ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

446466:CFLA RS11540
gene id: 446466:CFLA_RS11540
uniprot id: D5UGS5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

446466:CFLA RS04460
gene id: 446466:CFLA_RS04460
uniprot id: D5UK55
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

446466:CFLA RS15575
gene id: 446466:CFLA_RS15575
uniprot id: D5UL83
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS20685
gene id: 446466:CFLA_RS20685
uniprot id: D5UIW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

446466:CFLA RS10125
gene id: 446466:CFLA_RS10125
uniprot id: D5UF98
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
messages: The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

446466:CFLA RS09170
gene id: 446466:CFLA_RS09170
uniprot id: D5UEQ0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS05845
gene id: 446466:CFLA_RS05845
uniprot id: D5ULL9
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS14605
gene id: 446466:CFLA_RS14605
uniprot id: D5UKB3
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS03310
gene id: 446466:CFLA_RS03310
uniprot id: D5UJ47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

446466:CFLA RS16230
gene id: 446466:CFLA_RS16230
uniprot id: D5ULZ2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13405
gene id: 446466:CFLA_RS13405
uniprot id: D5UIX6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

446466:CFLA RS05875
gene id: 446466:CFLA_RS05875
uniprot id: D5ULM5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

446466:CFLA RS18240
gene id: 446466:CFLA_RS18240
uniprot id: D5UDN9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

446466:CFLA RS17270
gene id: 446466:CFLA_RS17270
uniprot id: D5UCR8
names: Function
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

446466:CFLA RS04595
gene id: 446466:CFLA_RS04595
uniprot id: D5UKK6
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS03920
gene id: 446466:CFLA_RS03920
uniprot id: D5UJG6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

446466:CFLA RS13150
gene id: 446466:CFLA_RS13150
uniprot id: D5UIS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

446466:CFLA RS04740
gene id: 446466:CFLA_RS04740
uniprot id: D5UKN4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

446466:CFLA RS06115
gene id: 446466:CFLA_RS06115
uniprot id: D5UBL8
names: Similarity
messages: Belongs to the GSP E family.

446466:CFLA RS07085
gene id: 446466:CFLA_RS07085
uniprot id: D5UCI7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

446466:CFLA RS05135
gene id: 446466:CFLA_RS05135
uniprot id: D5UKV8
names: Similarity
messages: Belongs to the BMP lipoprotein family.

446466:CFLA RS17365
gene id: 446466:CFLA_RS17365
uniprot id: D5UCT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Membrane

446466:CFLA RS15750
gene id: 446466:CFLA_RS15750
uniprot id: D5ULP5
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

446466:CFLA RS14425
gene id: 446466:CFLA_RS14425
uniprot id: D5UJV0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

446466:CFLA RS06165
gene id: 446466:CFLA_RS06165
uniprot id: D5UBM9
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS05885
gene id: 446466:CFLA_RS05885
uniprot id: D5ULM7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS10885
gene id: 446466:CFLA_RS10885
uniprot id: D5UG21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

446466:CFLA RS12075
gene id: 446466:CFLA_RS12075
uniprot id: D5UHF6
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

446466:CFLA RS09630
gene id: 446466:CFLA_RS09630
uniprot id: D5UEZ1
names: Similarity
messages: Belongs to the Dps family.

446466:CFLA RS07875
gene id: 446466:CFLA_RS07875
uniprot id: D5UDQ0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS10435
gene id: 446466:CFLA_RS10435
uniprot id: D5UFF9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

446466:CFLA RS13810
gene id: 446466:CFLA_RS13810
uniprot id: D5UJH9
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS04100
gene id: 446466:CFLA_RS04100
uniprot id: D5UJY2
names: Similarity
messages: Belongs to the YciI family.

446466:CFLA RS09390
gene id: 446466:CFLA_RS09390
uniprot id: D5UEU2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

446466:CFLA RS10660
gene id: 446466:CFLA_RS10660
uniprot id: D5UFX7
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS11970
gene id: 446466:CFLA_RS11970
uniprot id: D5UHD5
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS17325
gene id: 446466:CFLA_RS17325
uniprot id: D5UCS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS07615
gene id: 446466:CFLA_RS07615
uniprot id: D5UD69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

446466:CFLA RS11555
gene id: 446466:CFLA_RS11555
uniprot id: D5UGS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

446466:CFLA RS18045
gene id: 446466:CFLA_RS18045
uniprot id: D5UDK0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

446466:CFLA RS11190
gene id: 446466:CFLA_RS11190
uniprot id: D5UGK3
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

446466:CFLA RS06575
gene id: 446466:CFLA_RS06575
uniprot id: D5UC92
names: Similarity
messages: Belongs to the HSP15 family.

446466:CFLA RS02780
gene id: 446466:CFLA_RS02780
uniprot id: D5UIG5
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

446466:CFLA RS02555
gene id: 446466:CFLA_RS02555
uniprot id: D5UHZ8
names: Similarity
messages: Belongs to the pirin family.

446466:CFLA RS12120
gene id: 446466:CFLA_RS12120
uniprot id: D5UHG5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

446466:CFLA RS13410
gene id: 446466:CFLA_RS13410
uniprot id: D5UIX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

446466:CFLA RS01850
gene id: 446466:CFLA_RS01850
uniprot id: D5UH80
names: Similarity
messages: Belongs to the peptidase S1 family.

446466:CFLA RS15275
gene id: 446466:CFLA_RS15275
uniprot id: D5UL23
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

446466:CFLA RS07650
gene id: 446466:CFLA_RS07650
uniprot id: D5UD76
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

446466:CFLA RS10510
gene id: 446466:CFLA_RS10510
uniprot id: D5UFH4
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

446466:CFLA RS03885
gene id: 446466:CFLA_RS03885
uniprot id: D5UJF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS10475
gene id: 446466:CFLA_RS10475
uniprot id: D5UFG7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

446466:CFLA RS03340
gene id: 446466:CFLA_RS03340
uniprot id: D5UJ53
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

446466:CFLA RS01915
gene id: 446466:CFLA_RS01915
uniprot id: D5UH93
names: Subcellular Location Annotation
messages: Cytoplasm

446466:CFLA RS09030
gene id: 446466:CFLA_RS09030
uniprot id: D5UEM2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

446466:CFLA RS09020
gene id: 446466:CFLA_RS09020
uniprot id: D5UEM0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS06845
gene id: 446466:CFLA_RS06845
uniprot id: D5UCE2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

446466:CFLA RS17295
gene id: 446466:CFLA_RS17295
uniprot id: D5UCS3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

446466:CFLA RS10525
gene id: 446466:CFLA_RS10525
uniprot id: D5UFV1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

446466:CFLA RS03460
gene id: 446466:CFLA_RS03460
uniprot id: D5UJ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

446466:CFLA RS06230
gene id: 446466:CFLA_RS06230
uniprot id: D5UBP1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS11255
gene id: 446466:CFLA_RS11255
uniprot id: D5UGL6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

446466:CFLA RS14160
gene id: 446466:CFLA_RS14160
uniprot id: D5UJP7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

446466:CFLA RS12575
gene id: 446466:CFLA_RS12575
uniprot id: D5UI32
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

446466:CFLA RS09100
gene id: 446466:CFLA_RS09100
uniprot id: D5UEN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

446466:CFLA RS11590
gene id: 446466:CFLA_RS11590
uniprot id: D5UGT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

446466:CFLA RS10900
gene id: 446466:CFLA_RS10900
uniprot id: D5UG24
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.

446466:CFLA RS07820
gene id: 446466:CFLA_RS07820
uniprot id: D5UDB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS13365
gene id: 446466:CFLA_RS13365
uniprot id: D5UIW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

446466:CFLA RS13855
gene id: 446466:CFLA_RS13855
uniprot id: D5UJI8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

446466:CFLA RS00420
gene id: 446466:CFLA_RS00420
uniprot id: D5UFP1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

446466:CFLA RS14885
gene id: 446466:CFLA_RS14885
uniprot id: D5UKG6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

446466:CFLA RS02375
gene id: 446466:CFLA_RS02375
uniprot id: D5UHW4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS14625
gene id: 446466:CFLA_RS14625
uniprot id: D5UKB7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

446466:CFLA RS06085
gene id: 446466:CFLA_RS06085
uniprot id: D5UBL2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

446466:CFLA RS17130
gene id: 446466:CFLA_RS17130
uniprot id: D5UCP3
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

446466:CFLA RS06615
gene id: 446466:CFLA_RS06615
uniprot id: D5UC99
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

446466:CFLA RS09985
gene id: 446466:CFLA_RS09985
uniprot id: D5UF71
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS08290
gene id: 446466:CFLA_RS08290
uniprot id: D5UDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

446466:CFLA RS05065
gene id: 446466:CFLA_RS05065
uniprot id: D5UKU4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS06925
gene id: 446466:CFLA_RS06925
uniprot id: D5UCF8
names: Similarity
messages: Belongs to the peptidase M13 family.

446466:CFLA RS13195
gene id: 446466:CFLA_RS13195
uniprot id: D5UIT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

446466:CFLA RS14785
gene id: 446466:CFLA_RS14785
uniprot id: D5UKE6
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

446466:CFLA RS08885
gene id: 446466:CFLA_RS08885
uniprot id: D5UEJ7
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09935
gene id: 446466:CFLA_RS09935
uniprot id: D5UF61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS00005
gene id: 446466:CFLA_RS00005
uniprot id: D5UF34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

446466:CFLA RS08115
gene id: 446466:CFLA_RS08115
uniprot id: D5UDU9
names: Similarity
messages: Belongs to the AHA1 family.

446466:CFLA RS13100
gene id: 446466:CFLA_RS13100
uniprot id: D5UIR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

446466:CFLA RS05895
gene id: 446466:CFLA_RS05895
uniprot id: D5ULM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS13020
gene id: 446466:CFLA_RS13020
uniprot id: D5UIC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

446466:CFLA RS11315
gene id: 446466:CFLA_RS11315
uniprot id: D5UGM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS10865
gene id: 446466:CFLA_RS10865
uniprot id: D5UG18
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

446466:CFLA RS04200
gene id: 446466:CFLA_RS04200
uniprot id: D5UK04
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

446466:CFLA RS03600
gene id: 446466:CFLA_RS03600
uniprot id: D5UJA3
names: Similarity
messages: Belongs to the WXG100 family.

446466:CFLA RS07230
gene id: 446466:CFLA_RS07230
uniprot id: D5UCZ3
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

446466:CFLA RS14710
gene id: 446466:CFLA_RS14710
uniprot id: D5UKD0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

446466:CFLA RS07440
gene id: 446466:CFLA_RS07440
uniprot id: D5UD34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

446466:CFLA RS10990
gene id: 446466:CFLA_RS10990
uniprot id: D5UG38
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

446466:CFLA RS03000
gene id: 446466:CFLA_RS03000
uniprot id: D5UIK6
names: Similarity
messages: Belongs to the peptidase S8 family.

446466:CFLA RS08700
gene id: 446466:CFLA_RS08700
uniprot id: D5UEF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

446466:CFLA RS16295
gene id: 446466:CFLA_RS16295
uniprot id: D5UM05
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09670
gene id: 446466:CFLA_RS09670
uniprot id: D5UEZ8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS17775
gene id: 446466:CFLA_RS17775
uniprot id: D5UDE7
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

446466:CFLA RS14910
gene id: 446466:CFLA_RS14910
uniprot id: D5UKH1
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

446466:CFLA RS04875
gene id: 446466:CFLA_RS04875
uniprot id: D5UKQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

446466:CFLA RS19210
gene id: 446466:CFLA_RS19210
uniprot id: D5ULU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

446466:CFLA RS13865
gene id: 446466:CFLA_RS13865
uniprot id: D5UJJ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

446466:CFLA RS15345
gene id: 446466:CFLA_RS15345
uniprot id: D5UL37
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS18635
gene id: 446466:CFLA_RS18635
uniprot id: D5UE99
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS02830
gene id: 446466:CFLA_RS02830
uniprot id: D5UIH3
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

446466:CFLA RS06090
gene id: 446466:CFLA_RS06090
uniprot id: D5UBL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

446466:CFLA RS10035
gene id: 446466:CFLA_RS10035
uniprot id: D5UF80
names: Similarity
messages: Belongs to the glutamate synthase family.

446466:CFLA RS07560
gene id: 446466:CFLA_RS07560
uniprot id: D5UD58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

446466:CFLA RS05215
gene id: 446466:CFLA_RS05215
uniprot id: D5UKX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

446466:CFLA RS15060
gene id: 446466:CFLA_RS15060
uniprot id: D5UKK1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446466:CFLA RS00020
gene id: 446466:CFLA_RS00020
uniprot id: D5UF37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

446466:CFLA RS07355
gene id: 446466:CFLA_RS07355
uniprot id: D5UD17
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

446466:CFLA RS15405
gene id: 446466:CFLA_RS15405
uniprot id: D5UL49
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

446466:CFLA RS14805
gene id: 446466:CFLA_RS14805
uniprot id: D5UKF0
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

446466:CFLA RS18495
gene id: 446466:CFLA_RS18495
uniprot id: D5UE72
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

446466:CFLA RS11165
gene id: 446466:CFLA_RS11165
uniprot id: D5UG73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

446466:CFLA RS14415
gene id: 446466:CFLA_RS14415
uniprot id: D5UJU8
names: Similarity
messages: Belongs to the AHA1 family.

446466:CFLA RS12520
gene id: 446466:CFLA_RS12520
uniprot id: D5UI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS16810
gene id: 446466:CFLA_RS16810
uniprot id: D5UC54
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

446466:CFLA RS07805
gene id: 446466:CFLA_RS07805
uniprot id: D5UDA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

446466:CFLA RS12340
gene id: 446466:CFLA_RS12340
uniprot id: D5UHL0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446466:CFLA RS13395
gene id: 446466:CFLA_RS13395
uniprot id: D5UIX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

446466:CFLA RS18365
gene id: 446466:CFLA_RS18365
uniprot id: D5UE46
names: Similarity
messages: Belongs to the thioredoxin family.

446466:CFLA RS13675
gene id: 446466:CFLA_RS13675
uniprot id: D5UJ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

446466:CFLA RS02480
gene id: 446466:CFLA_RS02480
uniprot id: D5UHY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

446466:CFLA RS03635
gene id: 446466:CFLA_RS03635
uniprot id: D5UJB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

446466:CFLA RS13640
gene id: 446466:CFLA_RS13640
uniprot id: D5UJ17
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

446466:CFLA RS07840
gene id: 446466:CFLA_RS07840
uniprot id: D5UDB4
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

446466:CFLA RS16120
gene id: 446466:CFLA_RS16120
uniprot id: D5ULW9
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

446466:CFLA RS13440
gene id: 446466:CFLA_RS13440
uniprot id: D5UIY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

446466:CFLA RS07565
gene id: 446466:CFLA_RS07565
uniprot id: D5UD59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS11705
gene id: 446466:CFLA_RS11705
uniprot id: D5UGV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

446466:CFLA RS05945
gene id: 446466:CFLA_RS05945
uniprot id: D5UBI4
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS16945
gene id: 446466:CFLA_RS16945
uniprot id: D5UC83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS05190
gene id: 446466:CFLA_RS05190
uniprot id: D5UKW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.

446466:CFLA RS17495
gene id: 446466:CFLA_RS17495
uniprot id: D5UCW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS01150
gene id: 446466:CFLA_RS01150
uniprot id: D5UGG4
names: Similarity
messages: Belongs to the peptidase C56 family.

446466:CFLA RS11435
gene id: 446466:CFLA_RS11435
uniprot id: D5UGQ3
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

446466:CFLA RS13450
gene id: 446466:CFLA_RS13450
uniprot id: D5UIY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

446466:CFLA RS04805
gene id: 446466:CFLA_RS04805
uniprot id: D5UKP3
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09745
gene id: 446466:CFLA_RS09745
uniprot id: D5UF09
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

446466:CFLA RS10640
gene id: 446466:CFLA_RS10640
uniprot id: D5UFX3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

446466:CFLA RS00805
gene id: 446466:CFLA_RS00805
uniprot id: D5UG95
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

446466:CFLA RS08775
gene id: 446466:CFLA_RS08775
uniprot id: D5UEH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

446466:CFLA RS00625
gene id: 446466:CFLA_RS00625
uniprot id: D5UFT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

446466:CFLA RS11560
gene id: 446466:CFLA_RS11560
uniprot id: D5UGS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

446466:CFLA RS09285
gene id: 446466:CFLA_RS09285
uniprot id: D5UES2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS13155
gene id: 446466:CFLA_RS13155
uniprot id: D5UIS7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS03045
gene id: 446466:CFLA_RS03045
uniprot id: D5UIL5
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

446466:CFLA RS01590
gene id: 446466:CFLA_RS01590
uniprot id: D5UH29
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

446466:CFLA RS10135
gene id: 446466:CFLA_RS10135
uniprot id: D5UFA0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

446466:CFLA RS05620
gene id: 446466:CFLA_RS05620
uniprot id: D5ULH5
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

446466:CFLA RS16115
gene id: 446466:CFLA_RS16115
uniprot id: D5ULW8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

446466:CFLA RS10690
gene id: 446466:CFLA_RS10690
uniprot id: D5UFY3
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09940
gene id: 446466:CFLA_RS09940
uniprot id: D5UF62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS14075
gene id: 446466:CFLA_RS14075
uniprot id: D5UJN0
names: Function
names: Similarity
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.

446466:CFLA RS04645
gene id: 446466:CFLA_RS04645
uniprot id: D5UKL5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

446466:CFLA RS04165
gene id: 446466:CFLA_RS04165
uniprot id: D5UJZ7
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS04195
gene id: 446466:CFLA_RS04195
uniprot id: D5UK03
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

446466:CFLA RS05095
gene id: 446466:CFLA_RS05095
uniprot id: D5UKV0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS05160
gene id: 446466:CFLA_RS05160
uniprot id: D5UKW3
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

446466:CFLA RS00435
gene id: 446466:CFLA_RS00435
uniprot id: D5UFP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

446466:CFLA RS13085
gene id: 446466:CFLA_RS13085
uniprot id: D5UID4
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

446466:CFLA RS10895
gene id: 446466:CFLA_RS10895
uniprot id: D5UG23
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

446466:CFLA RS15985
gene id: 446466:CFLA_RS15985
uniprot id: D5ULU2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS05460
gene id: 446466:CFLA_RS05460
uniprot id: D5ULE7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

446466:CFLA RS04785
gene id: 446466:CFLA_RS04785
uniprot id: D5UKP1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS07575
gene id: 446466:CFLA_RS07575
uniprot id: D5UD61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

446466:CFLA RS04395
gene id: 446466:CFLA_RS04395
uniprot id: D5UK42
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09175
gene id: 446466:CFLA_RS09175
uniprot id: D5UEQ1
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

446466:CFLA RS05385
gene id: 446466:CFLA_RS05385
uniprot id: D5ULD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

446466:CFLA RS07220
gene id: 446466:CFLA_RS07220
uniprot id: D5UCZ1
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

446466:CFLA RS04295
gene id: 446466:CFLA_RS04295
uniprot id: D5UK23
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

446466:CFLA RS08225
gene id: 446466:CFLA_RS08225
uniprot id: D5UDX0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

446466:CFLA RS07520
gene id: 446466:CFLA_RS07520
uniprot id: D5UD50
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

446466:CFLA RS10780
gene id: 446466:CFLA_RS10780
uniprot id: D5UG02
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

446466:CFLA RS10210
gene id: 446466:CFLA_RS10210
uniprot id: D5UFB5
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

446466:CFLA RS18690
gene id: 446466:CFLA_RS18690
uniprot id: D5UEB0
names: Similarity
messages: Belongs to the thioredoxin family.

446466:CFLA RS09575
gene id: 446466:CFLA_RS09575
uniprot id: D5UEY0
names: Similarity
messages: Belongs to the DEAD box helicase family.

446466:CFLA RS00995
gene id: 446466:CFLA_RS00995
uniprot id: D5UGD3
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

446466:CFLA RS08760
gene id: 446466:CFLA_RS08760
uniprot id: D5UEH1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

446466:CFLA RS11895
gene id: 446466:CFLA_RS11895
uniprot id: D5UHC0
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.

446466:CFLA RS08025
gene id: 446466:CFLA_RS08025
uniprot id: D5UDT1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS05545
gene id: 446466:CFLA_RS05545
uniprot id: D5ULG0
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

446466:CFLA RS00110
gene id: 446466:CFLA_RS00110
uniprot id: D5UFI2
names: Similarity
messages: Belongs to the UPF0749 family.

446466:CFLA RS13125
gene id: 446466:CFLA_RS13125
uniprot id: D5UIS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

446466:CFLA RS07570
gene id: 446466:CFLA_RS07570
uniprot id: D5UD60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS05360
gene id: 446466:CFLA_RS05360
uniprot id: D5ULC7
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS02825
gene id: 446466:CFLA_RS02825
uniprot id: D5UIH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

446466:CFLA RS11690
gene id: 446466:CFLA_RS11690
uniprot id: D5UGV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

446466:CFLA RS16285
gene id: 446466:CFLA_RS16285
uniprot id: D5UM03
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

446466:CFLA RS04445
gene id: 446466:CFLA_RS04445
uniprot id: D5UK52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

446466:CFLA RS07860
gene id: 446466:CFLA_RS07860
uniprot id: D5UDP7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446466:CFLA RS14090
gene id: 446466:CFLA_RS14090
uniprot id: D5UJN3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

446466:CFLA RS04555
gene id: 446466:CFLA_RS04555
uniprot id: D5UK74
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

446466:CFLA RS15250
gene id: 446466:CFLA_RS15250
uniprot id: D5UL18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS01005
gene id: 446466:CFLA_RS01005
uniprot id: D5UGD5
names: Similarity
messages: Belongs to the IucA/IucC family.

446466:CFLA RS00495
gene id: 446466:CFLA_RS00495
uniprot id: D5UFQ8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446466:CFLA RS17420
gene id: 446466:CFLA_RS17420
uniprot id: D5UCU9
names: Similarity
messages: Belongs to the class-D beta-lactamase family.

446466:CFLA RS05305
gene id: 446466:CFLA_RS05305
uniprot id: D5ULB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

446466:CFLA RS08100
gene id: 446466:CFLA_RS08100
uniprot id: D5UDU6
names: Subcellular Location Annotation
messages: Cytoplasm

446466:CFLA RS03155
gene id: 446466:CFLA_RS03155
uniprot id: D5UIN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

446466:CFLA RS13260
gene id: 446466:CFLA_RS13260
uniprot id: D5UIU7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

446466:CFLA RS00810
gene id: 446466:CFLA_RS00810
uniprot id: D5UG96
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

446466:CFLA RS09825
gene id: 446466:CFLA_RS09825
uniprot id: D5UF25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

446466:CFLA RS01025
gene id: 446466:CFLA_RS01025
uniprot id: D5UGD9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

446466:CFLA RS18510
gene id: 446466:CFLA_RS18510
uniprot id: D5UE75
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

446466:CFLA RS12105
gene id: 446466:CFLA_RS12105
uniprot id: D5UHG2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09555
gene id: 446466:CFLA_RS09555
uniprot id: D5UEX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

446466:CFLA RS16080
gene id: 446466:CFLA_RS16080
uniprot id: D5ULW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

446466:CFLA RS08040
gene id: 446466:CFLA_RS08040
uniprot id: D5UDT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

446466:CFLA RS03830
gene id: 446466:CFLA_RS03830
uniprot id: D5UJE9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

446466:CFLA RS09065
gene id: 446466:CFLA_RS09065
uniprot id: D5UEM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

446466:CFLA RS14225
gene id: 446466:CFLA_RS14225
uniprot id: D5UJR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Monomer.

446466:CFLA RS07835
gene id: 446466:CFLA_RS07835
uniprot id: D5UDB3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

446466:CFLA RS06930
gene id: 446466:CFLA_RS06930
uniprot id: D5UCF9
names: Similarity
messages: Belongs to the LacAB/RpiB family.

446466:CFLA RS16135
gene id: 446466:CFLA_RS16135
uniprot id: D5ULX2
names: Similarity
messages: Belongs to the TPP enzyme family.

446466:CFLA RS04970
gene id: 446466:CFLA_RS04970
uniprot id: D5UKS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

446466:CFLA RS18210
gene id: 446466:CFLA_RS18210
uniprot id: D5UDN3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS05315
gene id: 446466:CFLA_RS05315
uniprot id: D5ULB8
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

446466:CFLA RS07170
gene id: 446466:CFLA_RS07170
uniprot id: D5UCK4
names: Similarity
messages: Belongs to the WXG100 family.

446466:CFLA RS05000
gene id: 446466:CFLA_RS05000
uniprot id: D5UKT1
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

446466:CFLA RS08745
gene id: 446466:CFLA_RS08745
uniprot id: D5UEG8
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

446466:CFLA RS09820
gene id: 446466:CFLA_RS09820
uniprot id: D5UF24
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

446466:CFLA RS13470
gene id: 446466:CFLA_RS13470
uniprot id: D5UIY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

446466:CFLA RS08460
gene id: 446466:CFLA_RS08460
uniprot id: D5UE13
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

446466:CFLA RS04625
gene id: 446466:CFLA_RS04625
uniprot id: D5UKL1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS10110
gene id: 446466:CFLA_RS10110
uniprot id: D5UF95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

446466:CFLA RS08200
gene id: 446466:CFLA_RS08200
uniprot id: D5UDW5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

446466:CFLA RS01960
gene id: 446466:CFLA_RS01960
uniprot id: D5UHA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS05300
gene id: 446466:CFLA_RS05300
uniprot id: D5ULB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

446466:CFLA RS18795
gene id: 446466:CFLA_RS18795
uniprot id: D5UGB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

446466:CFLA RS05085
gene id: 446466:CFLA_RS05085
uniprot id: D5UKU8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS07320
gene id: 446466:CFLA_RS07320
uniprot id: D5UD11
names: Similarity
messages: Belongs to the peptidase S66 family.

446466:CFLA RS18485
gene id: 446466:CFLA_RS18485
uniprot id: D5UE70
names: Similarity
messages: Belongs to the Lgt family.

446466:CFLA RS14070
gene id: 446466:CFLA_RS14070
uniprot id: D5UJM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

446466:CFLA RS01055
gene id: 446466:CFLA_RS01055
uniprot id: D5UGE5
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS12795
gene id: 446466:CFLA_RS12795
uniprot id: D5UI76
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

446466:CFLA RS08330
gene id: 446466:CFLA_RS08330
uniprot id: D5UDZ1
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

446466:CFLA RS10735
gene id: 446466:CFLA_RS10735
uniprot id: D5UFZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

446466:CFLA RS18405
gene id: 446466:CFLA_RS18405
uniprot id: D5UE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS05010
gene id: 446466:CFLA_RS05010
uniprot id: D5UKT3
names: Similarity
messages: Belongs to the citrate synthase family.

446466:CFLA RS08060
gene id: 446466:CFLA_RS08060
uniprot id: D5UDT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

446466:CFLA RS08635
gene id: 446466:CFLA_RS08635
uniprot id: D5UEE6
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13340
gene id: 446466:CFLA_RS13340
uniprot id: D5UIW3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

446466:CFLA RS11710
gene id: 446466:CFLA_RS11710
uniprot id: D5UGV8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

446466:CFLA RS13980
gene id: 446466:CFLA_RS13980
uniprot id: D5UJL2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS05110
gene id: 446466:CFLA_RS05110
uniprot id: D5UKV3
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

446466:CFLA RS00285
gene id: 446466:CFLA_RS00285
uniprot id: D5UFL5
names: Similarity
messages: Belongs to the IMPACT family.

446466:CFLA RS01880
gene id: 446466:CFLA_RS01880
uniprot id: D5UH86
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS04750
gene id: 446466:CFLA_RS04750
uniprot id: D5UKN6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS12960
gene id: 446466:CFLA_RS12960
uniprot id: D5UIA9
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS10875
gene id: 446466:CFLA_RS10875
uniprot id: D5UG19
names: Similarity
messages: Belongs to the CdaR family.

446466:CFLA RS02855
gene id: 446466:CFLA_RS02855
uniprot id: D5UIH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.

446466:CFLA RS07045
gene id: 446466:CFLA_RS07045
uniprot id: D5UCH9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

446466:CFLA RS13375
gene id: 446466:CFLA_RS13375
uniprot id: D5UIX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

446466:CFLA RS17620
gene id: 446466:CFLA_RS17620
uniprot id: D5UCY6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS08735
gene id: 446466:CFLA_RS08735
uniprot id: D5UEG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

446466:CFLA RS03210
gene id: 446466:CFLA_RS03210
uniprot id: D5UIQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

446466:CFLA RS12885
gene id: 446466:CFLA_RS12885
uniprot id: D5UI94
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

446466:CFLA RS06170
gene id: 446466:CFLA_RS06170
uniprot id: D5UBN0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09365
gene id: 446466:CFLA_RS09365
uniprot id: D5UET7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

446466:CFLA RS01250
gene id: 446466:CFLA_RS01250
uniprot id: D5UGI3
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS10460
gene id: 446466:CFLA_RS10460
uniprot id: D5UFG4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'P' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Non-allosteric.

446466:CFLA RS07370
gene id: 446466:CFLA_RS07370
uniprot id: D5UD20
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

446466:CFLA RS08555
gene id: 446466:CFLA_RS08555
uniprot id: D5UED0
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

446466:CFLA RS02860
gene id: 446466:CFLA_RS02860
uniprot id: D5UIH9
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

446466:CFLA RS09110
gene id: 446466:CFLA_RS09110
uniprot id: D5UEN8
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

446466:CFLA RS05860
gene id: 446466:CFLA_RS05860
uniprot id: D5ULM2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

446466:CFLA RS08250
gene id: 446466:CFLA_RS08250
uniprot id: D5UDX5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

446466:CFLA RS07250
gene id: 446466:CFLA_RS07250
uniprot id: D5UCZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS15100
gene id: 446466:CFLA_RS15100
uniprot id: D5UKY8
names: Similarity
messages: Belongs to the heat shock protein 90 family.

446466:CFLA RS17490
gene id: 446466:CFLA_RS17490
uniprot id: D5UCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

446466:CFLA RS15320
gene id: 446466:CFLA_RS15320
uniprot id: D5UL32
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

446466:CFLA RS18230
gene id: 446466:CFLA_RS18230
uniprot id: D5UDN7
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

446466:CFLA RS13730
gene id: 446466:CFLA_RS13730
uniprot id: D5UJ35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

446466:CFLA RS01900
gene id: 446466:CFLA_RS01900
uniprot id: D5UH90
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

446466:CFLA RS02145
gene id: 446466:CFLA_RS02145
uniprot id: D5UHR7
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS07665
gene id: 446466:CFLA_RS07665
uniprot id: D5UD79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

446466:CFLA RS07010
gene id: 446466:CFLA_RS07010
uniprot id: D5UCH4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

446466:CFLA RS08095
gene id: 446466:CFLA_RS08095
uniprot id: D5UDU5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

446466:CFLA RS15685
gene id: 446466:CFLA_RS15685
uniprot id: D5ULA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS11030
gene id: 446466:CFLA_RS11030
uniprot id: D5UG46
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

446466:CFLA RS15220
gene id: 446466:CFLA_RS15220
uniprot id: D5UL12
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

446466:CFLA RS04225
gene id: 446466:CFLA_RS04225
uniprot id: D5UK08
names: Similarity
messages: Belongs to the UDPGP type 1 family.

446466:CFLA RS04830
gene id: 446466:CFLA_RS04830
uniprot id: D5UKP8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

446466:CFLA RS19085
gene id: 446466:CFLA_RS19085
uniprot id: D5UHE8
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

446466:CFLA RS03135
gene id: 446466:CFLA_RS03135
uniprot id: D5UIN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

446466:CFLA RS19145
gene id: 446466:CFLA_RS19145
uniprot id: D5UJU3
names: Similarity
messages: Belongs to the ice-binding protein family.

446466:CFLA RS07400
gene id: 446466:CFLA_RS07400
uniprot id: D5UD26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS04340
gene id: 446466:CFLA_RS04340
uniprot id: D5UK32
names: Similarity
messages: Belongs to the AHA1 family.

446466:CFLA RS12355
gene id: 446466:CFLA_RS12355
uniprot id: D5UHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

446466:CFLA RS00085
gene id: 446466:CFLA_RS00085
uniprot id: D5UFH7
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

446466:CFLA RS07040
gene id: 446466:CFLA_RS07040
uniprot id: D5UCH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

446466:CFLA RS04705
gene id: 446466:CFLA_RS04705
uniprot id: D5UKM7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446466:CFLA RS09595
gene id: 446466:CFLA_RS09595
uniprot id: D5UEY4
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

446466:CFLA RS08800
gene id: 446466:CFLA_RS08800
uniprot id: D5UEI0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446466:CFLA RS07395
gene id: 446466:CFLA_RS07395
uniprot id: D5UD25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

446466:CFLA RS16020
gene id: 446466:CFLA_RS16020
uniprot id: D5ULU8
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

446466:CFLA RS13505
gene id: 446466:CFLA_RS13505
uniprot id: D5UIZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

446466:CFLA RS14850
gene id: 446466:CFLA_RS14850
uniprot id: D5UKF9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

446466:CFLA RS13005
gene id: 446466:CFLA_RS13005
uniprot id: D5UIB8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS15360
gene id: 446466:CFLA_RS15360
uniprot id: D5UL40
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS10495
gene id: 446466:CFLA_RS10495
uniprot id: D5UFH1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS04180
gene id: 446466:CFLA_RS04180
uniprot id: D5UK00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

446466:CFLA RS18995
gene id: 446466:CFLA_RS18995
uniprot id: D5UDV6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

446466:CFLA RS08190
gene id: 446466:CFLA_RS08190
uniprot id: D5UDW3
names: Similarity
messages: Belongs to the Fur family.

446466:CFLA RS09855
gene id: 446466:CFLA_RS09855
uniprot id: D5UF31
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

446466:CFLA RS07515
gene id: 446466:CFLA_RS07515
uniprot id: D5UD49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

446466:CFLA RS13910
gene id: 446466:CFLA_RS13910
uniprot id: D5UJK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

446466:CFLA RS17545
gene id: 446466:CFLA_RS17545
uniprot id: D5UCX4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446466:CFLA RS06690
gene id: 446466:CFLA_RS06690
uniprot id: D5UCB5
names: Similarity
messages: Belongs to the thioredoxin family.

446466:CFLA RS01545
gene id: 446466:CFLA_RS01545
uniprot id: D5UH21
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS12145
gene id: 446466:CFLA_RS12145
uniprot id: D5UHH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS16010
gene id: 446466:CFLA_RS16010
uniprot id: D5ULU6
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

446466:CFLA RS08650
gene id: 446466:CFLA_RS08650
uniprot id: D5UEE9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

446466:CFLA RS03345
gene id: 446466:CFLA_RS03345
uniprot id: D5UJ54
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS08080
gene id: 446466:CFLA_RS08080
uniprot id: D5UDU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

446466:CFLA RS07030
gene id: 446466:CFLA_RS07030
uniprot id: D5UCH6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

446466:CFLA RS19255
gene id: 446466:CFLA_RS19255
uniprot id: D5UCR3
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

446466:CFLA RS11180
gene id: 446466:CFLA_RS11180
uniprot id: D5UGK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

446466:CFLA RS11000
gene id: 446466:CFLA_RS11000
uniprot id: D5UG40
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

446466:CFLA RS09305
gene id: 446466:CFLA_RS09305
uniprot id: D5UES5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

446466:CFLA RS14245
gene id: 446466:CFLA_RS14245
uniprot id: D5UJR5
names: Similarity
messages: Belongs to the PhoU family.
messages: Belongs to the UPF0111 family.

446466:CFLA RS13635
gene id: 446466:CFLA_RS13635
uniprot id: D5UJ16
names: Similarity
messages: Belongs to the UPF0234 family.

446466:CFLA RS15310
gene id: 446466:CFLA_RS15310
uniprot id: D5UL30
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

446466:CFLA RS03890
gene id: 446466:CFLA_RS03890
uniprot id: D5UJG0
names: Similarity
messages: Belongs to the peptidase C40 family.

446466:CFLA RS14600
gene id: 446466:CFLA_RS14600
uniprot id: D5UKB2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS04665
gene id: 446466:CFLA_RS04665
uniprot id: D5UKL9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

446466:CFLA RS08445
gene id: 446466:CFLA_RS08445
uniprot id: D5UE10
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

446466:CFLA RS07670
gene id: 446466:CFLA_RS07670
uniprot id: D5UD80
names: Similarity
messages: Belongs to the peptidase M16 family.

446466:CFLA RS14460
gene id: 446466:CFLA_RS14460
uniprot id: D5UK84
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS05330
gene id: 446466:CFLA_RS05330
uniprot id: D5ULC1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS03200
gene id: 446466:CFLA_RS03200
uniprot id: D5UIP8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

446466:CFLA RS06815
gene id: 446466:CFLA_RS06815
uniprot id: D5UCD6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

446466:CFLA RS07595
gene id: 446466:CFLA_RS07595
uniprot id: D5UD65
names: Similarity
messages: Belongs to the FPG family.

446466:CFLA RS08140
gene id: 446466:CFLA_RS08140
uniprot id: D5UDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

446466:CFLA RS13720
gene id: 446466:CFLA_RS13720
uniprot id: D5UJ33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

446466:CFLA RS08905
gene id: 446466:CFLA_RS08905
uniprot id: D5UEK1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS08030
gene id: 446466:CFLA_RS08030
uniprot id: D5UDT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

446466:CFLA RS00935
gene id: 446466:CFLA_RS00935
uniprot id: D5UGC1
names: Similarity
messages: Belongs to the LacAB/RpiB family.

446466:CFLA RS00980
gene id: 446466:CFLA_RS00980
uniprot id: D5UGD0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS01450
gene id: 446466:CFLA_RS01450
uniprot id: D5UH02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS08715
gene id: 446466:CFLA_RS08715
uniprot id: D5UEG2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

446466:CFLA RS07925
gene id: 446466:CFLA_RS07925
uniprot id: D5UDR1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

446466:CFLA RS15600
gene id: 446466:CFLA_RS15600
uniprot id: D5UL88
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

446466:CFLA RS16935
gene id: 446466:CFLA_RS16935
uniprot id: D5UC81
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. Sucrose phosphorylase subfamily.

446466:CFLA RS15470
gene id: 446466:CFLA_RS15470
uniprot id: D5UL63
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

446466:CFLA RS14550
gene id: 446466:CFLA_RS14550
uniprot id: D5UKA2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09340
gene id: 446466:CFLA_RS09340
uniprot id: D5UET2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

446466:CFLA RS04890
gene id: 446466:CFLA_RS04890
uniprot id: D5UKQ9
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

446466:CFLA RS12160
gene id: 446466:CFLA_RS12160
uniprot id: D5UHH3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

446466:CFLA RS04415
gene id: 446466:CFLA_RS04415
uniprot id: D5UK46
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

446466:CFLA RS17100
gene id: 446466:CFLA_RS17100
uniprot id: D5UCN7
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

446466:CFLA RS17030
gene id: 446466:CFLA_RS17030
uniprot id: D5UCM4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

446466:CFLA RS00385
gene id: 446466:CFLA_RS00385
uniprot id: D5UFN5
names: Similarity
messages: Belongs to the malate synthase family.

446466:CFLA RS06610
gene id: 446466:CFLA_RS06610
uniprot id: D5UC98
names: Similarity
messages: Belongs to the polysaccharide lyase 3 family.

446466:CFLA RS18455
gene id: 446466:CFLA_RS18455
uniprot id: D5UE64
names: Similarity
messages: Belongs to the CsoR family.

446466:CFLA RS17610
gene id: 446466:CFLA_RS17610
uniprot id: D5UCY5
names: Similarity
messages: Belongs to the cytochrome P450 family.

446466:CFLA RS11035
gene id: 446466:CFLA_RS11035
uniprot id: D5UG47
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS00485
gene id: 446466:CFLA_RS00485
uniprot id: D5UFQ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

446466:CFLA RS11155
gene id: 446466:CFLA_RS11155
uniprot id: D5UG71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

446466:CFLA RS13400
gene id: 446466:CFLA_RS13400
uniprot id: D5UIX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

446466:CFLA RS13490
gene id: 446466:CFLA_RS13490
uniprot id: D5UIZ3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS09795
gene id: 446466:CFLA_RS09795
uniprot id: D5UF19
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Homodimer.

446466:CFLA RS05400
gene id: 446466:CFLA_RS05400
uniprot id: D5ULD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

446466:CFLA RS04540
gene id: 446466:CFLA_RS04540
uniprot id: D5UK71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

446466:CFLA RS04845
gene id: 446466:CFLA_RS04845
uniprot id: D5UKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS16835
gene id: 446466:CFLA_RS16835
uniprot id: D5UC59
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13590
gene id: 446466:CFLA_RS13590
uniprot id: D5UJ10
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS16760
gene id: 446466:CFLA_RS16760
uniprot id: D5UC44
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS14725
gene id: 446466:CFLA_RS14725
uniprot id: D5UKD3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

446466:CFLA RS09425
gene id: 446466:CFLA_RS09425
uniprot id: D5UEU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

446466:CFLA RS08220
gene id: 446466:CFLA_RS08220
uniprot id: D5UDW9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

446466:CFLA RS13265
gene id: 446466:CFLA_RS13265
uniprot id: D5UIU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

446466:CFLA RS03280
gene id: 446466:CFLA_RS03280
uniprot id: D5UIR5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS08035
gene id: 446466:CFLA_RS08035
uniprot id: D5UDT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

446466:CFLA RS12965
gene id: 446466:CFLA_RS12965
uniprot id: D5UIB0
names: Similarity
messages: Belongs to the GSP E family.

446466:CFLA RS13335
gene id: 446466:CFLA_RS13335
uniprot id: D5UIW2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

446466:CFLA RS10130
gene id: 446466:CFLA_RS10130
uniprot id: D5UF99
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
messages: The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

446466:CFLA RS14045
gene id: 446466:CFLA_RS14045
uniprot id: D5UJM4
names: Similarity
messages: Belongs to the GSP E family.

446466:CFLA RS18595
gene id: 446466:CFLA_RS18595
uniprot id: D5UE91
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS05145
gene id: 446466:CFLA_RS05145
uniprot id: D5UKW0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS05670
gene id: 446466:CFLA_RS05670
uniprot id: D5ULI4
names: Similarity
messages: Belongs to the DNA photolyase family.

446466:CFLA RS03160
gene id: 446466:CFLA_RS03160
uniprot id: D5UIP0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS02140
gene id: 446466:CFLA_RS02140
uniprot id: D5UHR6
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS07430
gene id: 446466:CFLA_RS07430
uniprot id: D5UD32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

446466:CFLA RS10175
gene id: 446466:CFLA_RS10175
uniprot id: D5UFA8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

446466:CFLA RS04745
gene id: 446466:CFLA_RS04745
uniprot id: D5UKN5
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS07470
gene id: 446466:CFLA_RS07470
uniprot id: D5UD40
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

446466:CFLA RS05855
gene id: 446466:CFLA_RS05855
uniprot id: D5ULM1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS06095
gene id: 446466:CFLA_RS06095
uniprot id: D5UBL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446466:CFLA RS04825
gene id: 446466:CFLA_RS04825
uniprot id: D5UKP7
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13180
gene id: 446466:CFLA_RS13180
uniprot id: D5UIT2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

446466:CFLA RS16850
gene id: 446466:CFLA_RS16850
uniprot id: D5UC63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes.

446466:CFLA RS06470
gene id: 446466:CFLA_RS06470
uniprot id: D5UBU0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

446466:CFLA RS09135
gene id: 446466:CFLA_RS09135
uniprot id: D5UEP3
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

446466:CFLA RS07625
gene id: 446466:CFLA_RS07625
uniprot id: D5UD71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

446466:CFLA RS12955
gene id: 446466:CFLA_RS12955
uniprot id: D5UIA8
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS16275
gene id: 446466:CFLA_RS16275
uniprot id: D5UM01
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446466:CFLA RS08310
gene id: 446466:CFLA_RS08310
uniprot id: D5UDY7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS06970
gene id: 446466:CFLA_RS06970
uniprot id: D5UCG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

446466:CFLA RS10120
gene id: 446466:CFLA_RS10120
uniprot id: D5UF97
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

446466:CFLA RS09460
gene id: 446466:CFLA_RS09460
uniprot id: D5UEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

446466:CFLA RS09380
gene id: 446466:CFLA_RS09380
uniprot id: D5UEU0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS13280
gene id: 446466:CFLA_RS13280
uniprot id: D5UIV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

446466:CFLA RS20720
gene id: 446466:CFLA_RS20720
uniprot id: D5UC74
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

446466:CFLA RS13055
gene id: 446466:CFLA_RS13055
uniprot id: D5UIC8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

446466:CFLA RS12530
gene id: 446466:CFLA_RS12530
uniprot id: D5UI24
names: Similarity
messages: Belongs to the peptidase M24B family.

446466:CFLA RS09835
gene id: 446466:CFLA_RS09835
uniprot id: D5UF27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

446466:CFLA RS18590
gene id: 446466:CFLA_RS18590
uniprot id: D5UE90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

446466:CFLA RS12775
gene id: 446466:CFLA_RS12775
uniprot id: D5UI72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

446466:CFLA RS06235
gene id: 446466:CFLA_RS06235
uniprot id: D5UBP2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS07715
gene id: 446466:CFLA_RS07715
uniprot id: D5UD89
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

446466:CFLA RS11505
gene id: 446466:CFLA_RS11505
uniprot id: D5UGR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

446466:CFLA RS00660
gene id: 446466:CFLA_RS00660
uniprot id: D5UFU1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS08780
gene id: 446466:CFLA_RS08780
uniprot id: D5UEH6
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

446466:CFLA RS17340
gene id: 446466:CFLA_RS17340
uniprot id: D5UCT2
names: Similarity
messages: Belongs to the CsoR family.

446466:CFLA RS11185
gene id: 446466:CFLA_RS11185
uniprot id: D5UGK2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

446466:CFLA RS09075
gene id: 446466:CFLA_RS09075
uniprot id: D5UEN1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

446466:CFLA RS01310
gene id: 446466:CFLA_RS01310
uniprot id: D5UGJ5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

446466:CFLA RS09610
gene id: 446466:CFLA_RS09610
uniprot id: D5UEY7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

446466:CFLA RS19200
gene id: 446466:CFLA_RS19200
uniprot id: D5ULT9
names: Similarity
messages: Belongs to the UPF0098 family.

446466:CFLA RS03240
gene id: 446466:CFLA_RS03240
uniprot id: D5UIQ7
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

446466:CFLA RS13070
gene id: 446466:CFLA_RS13070
uniprot id: D5UID1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

446466:CFLA RS06955
gene id: 446466:CFLA_RS06955
uniprot id: D5UCG4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446466:CFLA RS07710
gene id: 446466:CFLA_RS07710
uniprot id: D5UD88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS10055
gene id: 446466:CFLA_RS10055
uniprot id: D5UF84
names: Similarity
messages: Belongs to the TrpC family.

446466:CFLA RS12720
gene id: 446466:CFLA_RS12720
uniprot id: D5UI61
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS14260
gene id: 446466:CFLA_RS14260
uniprot id: D5UJR8
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS06665
gene id: 446466:CFLA_RS06665
uniprot id: D5UCB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

446466:CFLA RS07660
gene id: 446466:CFLA_RS07660
uniprot id: D5UD78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

446466:CFLA RS18685
gene id: 446466:CFLA_RS18685
uniprot id: D5UEA9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

446466:CFLA RS15960
gene id: 446466:CFLA_RS15960
uniprot id: D5ULT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS15775
gene id: 446466:CFLA_RS15775
uniprot id: D5ULQ0
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

446466:CFLA RS00375
gene id: 446466:CFLA_RS00375
uniprot id: D5UFN3
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

446466:CFLA RS00715
gene id: 446466:CFLA_RS00715
uniprot id: D5UG79
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13510
gene id: 446466:CFLA_RS13510
uniprot id: D5UIZ7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

446466:CFLA RS02700
gene id: 446466:CFLA_RS02700
uniprot id: D5UIF0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS10045
gene id: 446466:CFLA_RS10045
uniprot id: D5UF82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

446466:CFLA RS04535
gene id: 446466:CFLA_RS04535
uniprot id: D5UK70
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

446466:CFLA RS16140
gene id: 446466:CFLA_RS16140
uniprot id: D5ULX3
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS01065
gene id: 446466:CFLA_RS01065
uniprot id: D5UGE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS18720
gene id: 446466:CFLA_RS18720
uniprot id: D5UEB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

446466:CFLA RS13075
gene id: 446466:CFLA_RS13075
uniprot id: D5UID2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

446466:CFLA RS05200
gene id: 446466:CFLA_RS05200
uniprot id: D5UKX1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446466:CFLA RS03245
gene id: 446466:CFLA_RS03245
uniprot id: D5UIQ8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS12495
gene id: 446466:CFLA_RS12495
uniprot id: D5UI17
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

446466:CFLA RS01735
gene id: 446466:CFLA_RS01735
uniprot id: D5UH58
names: Similarity
messages: Belongs to the cytochrome P450 family.

446466:CFLA RS02710
gene id: 446466:CFLA_RS02710
uniprot id: D5UIF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS07425
gene id: 446466:CFLA_RS07425
uniprot id: D5UD31
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

446466:CFLA RS02215
gene id: 446466:CFLA_RS02215
uniprot id: D5UHT1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

446466:CFLA RS14175
gene id: 446466:CFLA_RS14175
uniprot id: D5UJQ0
names: Similarity
messages: Belongs to the malic enzymes family.

446466:CFLA RS03655
gene id: 446466:CFLA_RS03655
uniprot id: D5UJB3
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

446466:CFLA RS07260
gene id: 446466:CFLA_RS07260
uniprot id: D5UCZ9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

446466:CFLA RS13010
gene id: 446466:CFLA_RS13010
uniprot id: D5UIB9
names: Similarity
messages: Belongs to the XFP family.

446466:CFLA RS09070
gene id: 446466:CFLA_RS09070
uniprot id: D5UEN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

446466:CFLA RS08935
gene id: 446466:CFLA_RS08935
uniprot id: D5UEK7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

446466:CFLA RS14645
gene id: 446466:CFLA_RS14645
uniprot id: D5UKC1
names: Similarity
messages: Belongs to the peptidase S1 family.

446466:CFLA RS07540
gene id: 446466:CFLA_RS07540
uniprot id: D5UD54
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

446466:CFLA RS08790
gene id: 446466:CFLA_RS08790
uniprot id: D5UEH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

446466:CFLA RS08900
gene id: 446466:CFLA_RS08900
uniprot id: D5UEK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS13050
gene id: 446466:CFLA_RS13050
uniprot id: D5UIC7
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

446466:CFLA RS06740
gene id: 446466:CFLA_RS06740
uniprot id: D5UCC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS05175
gene id: 446466:CFLA_RS05175
uniprot id: D5UKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

446466:CFLA RS16220
gene id: 446466:CFLA_RS16220
uniprot id: D5ULZ0
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

446466:CFLA RS11660
gene id: 446466:CFLA_RS11660
uniprot id: D5UGU8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

446466:CFLA RS11595
gene id: 446466:CFLA_RS11595
uniprot id: D5UGT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

446466:CFLA RS18775
gene id: 446466:CFLA_RS18775
uniprot id: D5UFN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

446466:CFLA RS07415
gene id: 446466:CFLA_RS07415
uniprot id: D5UD29
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

446466:CFLA RS14705
gene id: 446466:CFLA_RS14705
uniprot id: D5UKC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

446466:CFLA RS15390
gene id: 446466:CFLA_RS15390
uniprot id: D5UL46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

446466:CFLA RS18260
gene id: 446466:CFLA_RS18260
uniprot id: D5UDP3
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

446466:CFLA RS08495
gene id: 446466:CFLA_RS08495
uniprot id: D5UE20
names: Similarity
messages: Belongs to the BioY family.

446466:CFLA RS13290
gene id: 446466:CFLA_RS13290
uniprot id: D5UIV3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446466:CFLA RS01475
gene id: 446466:CFLA_RS01475
uniprot id: D5UH07
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

446466:CFLA RS00105
gene id: 446466:CFLA_RS00105
uniprot id: D5UFI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

446466:CFLA RS10845
gene id: 446466:CFLA_RS10845
uniprot id: D5UG15
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446466:CFLA RS08955
gene id: 446466:CFLA_RS08955
uniprot id: D5UEL1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

446466:CFLA RS00425
gene id: 446466:CFLA_RS00425
uniprot id: D5UFP2
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS07005
gene id: 446466:CFLA_RS07005
uniprot id: D5UCH3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

446466:CFLA RS11525
gene id: 446466:CFLA_RS11525
uniprot id: D5UGS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

446466:CFLA RS17750
gene id: 446466:CFLA_RS17750
uniprot id: D5UDE2
names: Similarity
messages: Belongs to the globin family. Two-domain flavohemoproteins subfamily.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

446466:CFLA RS12825
gene id: 446466:CFLA_RS12825
uniprot id: D5UI82
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

446466:CFLA RS02770
gene id: 446466:CFLA_RS02770
uniprot id: D5UIG3
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

446466:CFLA RS05255
gene id: 446466:CFLA_RS05255
uniprot id: D5ULA7
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

446466:CFLA RS11780
gene id: 446466:CFLA_RS11780
uniprot id: D5UGX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

446466:CFLA RS04950
gene id: 446466:CFLA_RS04950
uniprot id: D5UKS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS10025
gene id: 446466:CFLA_RS10025
uniprot id: D5UF78
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

446466:CFLA RS03590
gene id: 446466:CFLA_RS03590
uniprot id: D5UJA1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS07445
gene id: 446466:CFLA_RS07445
uniprot id: D5UD35
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

446466:CFLA RS13430
gene id: 446466:CFLA_RS13430
uniprot id: D5UIY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

446466:CFLA RS02585
gene id: 446466:CFLA_RS02585
uniprot id: D5UI04
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446466:CFLA RS18280
gene id: 446466:CFLA_RS18280
uniprot id: D5UE27
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS04420
gene id: 446466:CFLA_RS04420
uniprot id: D5UK47
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS07495
gene id: 446466:CFLA_RS07495
uniprot id: D5UD45
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

446466:CFLA RS00095
gene id: 446466:CFLA_RS00095
uniprot id: D5UFH9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

446466:CFLA RS12580
gene id: 446466:CFLA_RS12580
uniprot id: D5UI33
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

446466:CFLA RS09590
gene id: 446466:CFLA_RS09590
uniprot id: D5UEY3
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

446466:CFLA RS08045
gene id: 446466:CFLA_RS08045
uniprot id: D5UDT5
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS17300
gene id: 446466:CFLA_RS17300
uniprot id: D5UCS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS02250
gene id: 446466:CFLA_RS02250
uniprot id: D5UHT8
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

446466:CFLA RS05560
gene id: 446466:CFLA_RS05560
uniprot id: D5ULG3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446466:CFLA RS10085
gene id: 446466:CFLA_RS10085
uniprot id: D5UF90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

446466:CFLA RS14240
gene id: 446466:CFLA_RS14240
uniprot id: D5UJR4
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09765
gene id: 446466:CFLA_RS09765
uniprot id: D5UF13
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

446466:CFLA RS14940
gene id: 446466:CFLA_RS14940
uniprot id: D5UKH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

446466:CFLA RS02235
gene id: 446466:CFLA_RS02235
uniprot id: D5UHT5
names: Similarity
messages: Belongs to the AAA ATPase family.

446466:CFLA RS15625
gene id: 446466:CFLA_RS15625
uniprot id: D5UL94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

446466:CFLA RS12815
gene id: 446466:CFLA_RS12815
uniprot id: D5UI80
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

446466:CFLA RS10695
gene id: 446466:CFLA_RS10695
uniprot id: D5UFY4
names: Similarity
messages: Belongs to the glutamine synthetase family.

446466:CFLA RS12435
gene id: 446466:CFLA_RS12435
uniprot id: D5UHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

446466:CFLA RS07380
gene id: 446466:CFLA_RS07380
uniprot id: D5UD22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

446466:CFLA RS15910
gene id: 446466:CFLA_RS15910
uniprot id: D5ULS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

446466:CFLA RS01060
gene id: 446466:CFLA_RS01060
uniprot id: D5UGE6
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS15165
gene id: 446466:CFLA_RS15165
uniprot id: D5UL01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS10645
gene id: 446466:CFLA_RS10645
uniprot id: D5UFX4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

446466:CFLA RS10840
gene id: 446466:CFLA_RS10840
uniprot id: D5UG14
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

446466:CFLA RS07315
gene id: 446466:CFLA_RS07315
uniprot id: D5UD10
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS04435
gene id: 446466:CFLA_RS04435
uniprot id: D5UK50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

446466:CFLA RS08590
gene id: 446466:CFLA_RS08590
uniprot id: D5UED7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

446466:CFLA RS03295
gene id: 446466:CFLA_RS03295
uniprot id: D5UJ44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

446466:CFLA RS11600
gene id: 446466:CFLA_RS11600
uniprot id: D5UGT7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

446466:CFLA RS00305
gene id: 446466:CFLA_RS00305
uniprot id: D5UFL9
names: Similarity
messages: Belongs to the UPF0225 family.

446466:CFLA RS09090
gene id: 446466:CFLA_RS09090
uniprot id: D5UEN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

446466:CFLA RS10420
gene id: 446466:CFLA_RS10420
uniprot id: D5UFF6
names: Similarity
messages: Belongs to the universal stress protein A family.

446466:CFLA RS08205
gene id: 446466:CFLA_RS08205
uniprot id: D5UDW6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

446466:CFLA RS08485
gene id: 446466:CFLA_RS08485
uniprot id: D5UE18
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13930
gene id: 446466:CFLA_RS13930
uniprot id: D5UJK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

446466:CFLA RS14875
gene id: 446466:CFLA_RS14875
uniprot id: D5UKG4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

446466:CFLA RS14735
gene id: 446466:CFLA_RS14735
uniprot id: D5UKD5
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

446466:CFLA RS04205
gene id: 446466:CFLA_RS04205
uniprot id: D5UK05
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

446466:CFLA RS08840
gene id: 446466:CFLA_RS08840
uniprot id: D5UEI8
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

446466:CFLA RS13955
gene id: 446466:CFLA_RS13955
uniprot id: D5UJK9
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

446466:CFLA RS12975
gene id: 446466:CFLA_RS12975
uniprot id: D5UIB2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS03320
gene id: 446466:CFLA_RS03320
uniprot id: D5UJ49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

446466:CFLA RS11490
gene id: 446466:CFLA_RS11490
uniprot id: D5UGR5
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

446466:CFLA RS17450
gene id: 446466:CFLA_RS17450
uniprot id: D5UCV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

446466:CFLA RS02420
gene id: 446466:CFLA_RS02420
uniprot id: D5UHX3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

446466:CFLA RS07800
gene id: 446466:CFLA_RS07800
uniprot id: D5UDA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

446466:CFLA RS10540
gene id: 446466:CFLA_RS10540
uniprot id: D5UFV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

446466:CFLA RS09150
gene id: 446466:CFLA_RS09150
uniprot id: D5UEP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS05450
gene id: 446466:CFLA_RS05450
uniprot id: D5ULE5
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

446466:CFLA RS08285
gene id: 446466:CFLA_RS08285
uniprot id: D5UDY2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

446466:CFLA RS13170
gene id: 446466:CFLA_RS13170
uniprot id: D5UIT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS13875
gene id: 446466:CFLA_RS13875
uniprot id: D5UJJ3
names: Similarity
messages: Belongs to the histone deacetylase family.

446466:CFLA RS04270
gene id: 446466:CFLA_RS04270
uniprot id: D5UK18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

446466:CFLA RS05965
gene id: 446466:CFLA_RS05965
uniprot id: D5UBI8
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

446466:CFLA RS08255
gene id: 446466:CFLA_RS08255
uniprot id: D5UDX6
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

446466:CFLA RS06910
gene id: 446466:CFLA_RS06910
uniprot id: D5UCF5
names: Similarity
messages: Belongs to the peptidase M1 family.

446466:CFLA RS03480
gene id: 446466:CFLA_RS03480
uniprot id: D5UJ78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

446466:CFLA RS08090
gene id: 446466:CFLA_RS08090
uniprot id: D5UDU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

446466:CFLA RS13520
gene id: 446466:CFLA_RS13520
uniprot id: D5UIZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

446466:CFLA RS06640
gene id: 446466:CFLA_RS06640
uniprot id: D5UCA5
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

446466:CFLA RS08540
gene id: 446466:CFLA_RS08540
uniprot id: D5UEC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

446466:CFLA RS09210
gene id: 446466:CFLA_RS09210
uniprot id: D5UEQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

446466:CFLA RS09490
gene id: 446466:CFLA_RS09490
uniprot id: D5UEW2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

446466:CFLA RS09330
gene id: 446466:CFLA_RS09330
uniprot id: D5UET0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

446466:CFLA RS13415
gene id: 446466:CFLA_RS13415
uniprot id: D5UIX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

446466:CFLA RS13285
gene id: 446466:CFLA_RS13285
uniprot id: D5UIV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

446466:CFLA RS07760
gene id: 446466:CFLA_RS07760
uniprot id: D5UD98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

446466:CFLA RS02515
gene id: 446466:CFLA_RS02515
uniprot id: D5UHZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS10520
gene id: 446466:CFLA_RS10520
uniprot id: D5UFV0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS17310
gene id: 446466:CFLA_RS17310
uniprot id: D5UCS6
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

446466:CFLA RS12470
gene id: 446466:CFLA_RS12470
uniprot id: D5UI12
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

446466:CFLA RS13685
gene id: 446466:CFLA_RS13685
uniprot id: D5UJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

446466:CFLA RS08305
gene id: 446466:CFLA_RS08305
uniprot id: D5UDY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

446466:CFLA RS05900
gene id: 446466:CFLA_RS05900
uniprot id: D5ULN0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

446466:CFLA RS03375
gene id: 446466:CFLA_RS03375
uniprot id: D5UJ60
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

446466:CFLA RS12595
gene id: 446466:CFLA_RS12595
uniprot id: D5UI36
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS00500
gene id: 446466:CFLA_RS00500
uniprot id: D5UFQ9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

446466:CFLA RS02325
gene id: 446466:CFLA_RS02325
uniprot id: D5UHV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

446466:CFLA RS09885
gene id: 446466:CFLA_RS09885
uniprot id: D5UF50
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

446466:CFLA RS02820
gene id: 446466:CFLA_RS02820
uniprot id: D5UIH1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS02600
gene id: 446466:CFLA_RS02600
uniprot id: D5UI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

446466:CFLA RS02715
gene id: 446466:CFLA_RS02715
uniprot id: D5UIF3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

446466:CFLA RS09925
gene id: 446466:CFLA_RS09925
uniprot id: D5UF59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS14975
gene id: 446466:CFLA_RS14975
uniprot id: D5UKI4
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13950
gene id: 446466:CFLA_RS13950
uniprot id: D5UJK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

446466:CFLA RS07350
gene id: 446466:CFLA_RS07350
uniprot id: D5UD16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

446466:CFLA RS05565
gene id: 446466:CFLA_RS05565
uniprot id: D5ULG4
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

446466:CFLA RS06935
gene id: 446466:CFLA_RS06935
uniprot id: D5UCG0
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase Eis family.
messages: Homohexamer; trimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS10365
gene id: 446466:CFLA_RS10365
uniprot id: D5UFE5
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS05405
gene id: 446466:CFLA_RS05405
uniprot id: D5ULD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

446466:CFLA RS09280
gene id: 446466:CFLA_RS09280
uniprot id: D5UES1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446466:CFLA RS11175
gene id: 446466:CFLA_RS11175
uniprot id: D5UGK0
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

446466:CFLA RS17440
gene id: 446466:CFLA_RS17440
uniprot id: D5UCV3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS06855
gene id: 446466:CFLA_RS06855
uniprot id: D5UCE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

446466:CFLA RS11365
gene id: 446466:CFLA_RS11365
uniprot id: D5UGN9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446466:CFLA RS13735
gene id: 446466:CFLA_RS13735
uniprot id: D5UJ36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

446466:CFLA RS09915
gene id: 446466:CFLA_RS09915
uniprot id: D5UF57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

446466:CFLA RS17480
gene id: 446466:CFLA_RS17480
uniprot id: D5UCW1
names: Similarity
messages: Belongs to the AHA1 family.

446466:CFLA RS02960
gene id: 446466:CFLA_RS02960
uniprot id: D5UIJ8
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS03575
gene id: 446466:CFLA_RS03575
uniprot id: D5UJ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

446466:CFLA RS11105
gene id: 446466:CFLA_RS11105
uniprot id: D5UG61
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

446466:CFLA RS08185
gene id: 446466:CFLA_RS08185
uniprot id: D5UDW2
names: Similarity
messages: Belongs to the catalase family.

446466:CFLA RS13350
gene id: 446466:CFLA_RS13350
uniprot id: D5UIW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

446466:CFLA RS02905
gene id: 446466:CFLA_RS02905
uniprot id: D5UII8
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

446466:CFLA RS16595
gene id: 446466:CFLA_RS16595
uniprot id: D5UC13
names: Similarity
messages: Belongs to the heat shock protein 70 family.

446466:CFLA RS14235
gene id: 446466:CFLA_RS14235
uniprot id: D5UJR3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446466:CFLA RS12555
gene id: 446466:CFLA_RS12555
uniprot id: D5UI29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

446466:CFLA RS02220
gene id: 446466:CFLA_RS02220
uniprot id: D5UHT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

446466:CFLA RS07775
gene id: 446466:CFLA_RS07775
uniprot id: D5UDA1
names: Similarity
messages: Belongs to the FPG family.

446466:CFLA RS09320
gene id: 446466:CFLA_RS09320
uniprot id: D5UES8
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

446466:CFLA RS16045
gene id: 446466:CFLA_RS16045
uniprot id: D5ULV3
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

446466:CFLA RS17330
gene id: 446466:CFLA_RS17330
uniprot id: D5UCT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS05700
gene id: 446466:CFLA_RS05700
uniprot id: D5ULJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS00065
gene id: 446466:CFLA_RS00065
uniprot id: D5UF45
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

446466:CFLA RS04240
gene id: 446466:CFLA_RS04240
uniprot id: D5UK11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Cell membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

446466:CFLA RS00535
gene id: 446466:CFLA_RS00535
uniprot id: D5UFR6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

446466:CFLA RS20980
gene id: 446466:CFLA_RS20980
uniprot id: D5UL25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.
messages: Secreted

446466:CFLA RS11080
gene id: 446466:CFLA_RS11080
uniprot id: D5UG56
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

446466:CFLA RS08585
gene id: 446466:CFLA_RS08585
uniprot id: D5UED6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

446466:CFLA RS10145
gene id: 446466:CFLA_RS10145
uniprot id: D5UFA2
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

446466:CFLA RS07895
gene id: 446466:CFLA_RS07895
uniprot id: D5UDQ4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS01625
gene id: 446466:CFLA_RS01625
uniprot id: D5UH36
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

446466:CFLA RS15460
gene id: 446466:CFLA_RS15460
uniprot id: D5UL61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbxX/CfxQ family.
messages: Cytoplasm

446466:CFLA RS05520
gene id: 446466:CFLA_RS05520
uniprot id: D5ULF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

446466:CFLA RS16130
gene id: 446466:CFLA_RS16130
uniprot id: D5ULX1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS04945
gene id: 446466:CFLA_RS04945
uniprot id: D5UKS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS08695
gene id: 446466:CFLA_RS08695
uniprot id: D5UEF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS08010
gene id: 446466:CFLA_RS08010
uniprot id: D5UDS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

446466:CFLA RS03715
gene id: 446466:CFLA_RS03715
uniprot id: D5UJC4
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

446466:CFLA RS08385
gene id: 446466:CFLA_RS08385
uniprot id: D5UDZ8
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

446466:CFLA RS01215
gene id: 446466:CFLA_RS01215
uniprot id: D5UGH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

446466:CFLA RS05570
gene id: 446466:CFLA_RS05570
uniprot id: D5ULG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

446466:CFLA RS08945
gene id: 446466:CFLA_RS08945
uniprot id: D5UEK9
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

446466:CFLA RS05910
gene id: 446466:CFLA_RS05910
uniprot id: D5ULN2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

446466:CFLA RS07725
gene id: 446466:CFLA_RS07725
uniprot id: D5UD91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

446466:CFLA RS17635
gene id: 446466:CFLA_RS17635
uniprot id: D5UDB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

446466:CFLA RS11110
gene id: 446466:CFLA_RS11110
uniprot id: D5UG62
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS14980
gene id: 446466:CFLA_RS14980
uniprot id: D5UKI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

446466:CFLA RS11885
gene id: 446466:CFLA_RS11885
uniprot id: D5UHB8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

446466:CFLA RS04440
gene id: 446466:CFLA_RS04440
uniprot id: D5UK51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

446466:CFLA RS07385
gene id: 446466:CFLA_RS07385
uniprot id: D5UD23
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

446466:CFLA RS07500
gene id: 446466:CFLA_RS07500
uniprot id: D5UD46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

446466:CFLA RS14610
gene id: 446466:CFLA_RS14610
uniprot id: D5UKB4
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

446466:CFLA RS18600
gene id: 446466:CFLA_RS18600
uniprot id: D5UE92
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

446466:CFLA RS12140
gene id: 446466:CFLA_RS12140
uniprot id: D5UHG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS07405
gene id: 446466:CFLA_RS07405
uniprot id: D5UD27
names: Similarity
messages: Belongs to the P(II) protein family.

446466:CFLA RS08525
gene id: 446466:CFLA_RS08525
uniprot id: D5UEC4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

446466:CFLA RS07035
gene id: 446466:CFLA_RS07035
uniprot id: D5UCH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

446466:CFLA RS05390
gene id: 446466:CFLA_RS05390
uniprot id: D5ULD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

446466:CFLA RS13715
gene id: 446466:CFLA_RS13715
uniprot id: D5UJ32
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

446466:CFLA RS13745
gene id: 446466:CFLA_RS13745
uniprot id: D5UJ38
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

446466:CFLA RS07915
gene id: 446466:CFLA_RS07915
uniprot id: D5UDQ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

446466:CFLA RS13360
gene id: 446466:CFLA_RS13360
uniprot id: D5UIW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

446466:CFLA RS04510
gene id: 446466:CFLA_RS04510
uniprot id: D5UK65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

446466:CFLA RS10370
gene id: 446466:CFLA_RS10370
uniprot id: D5UFE6
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

446466:CFLA RS04730
gene id: 446466:CFLA_RS04730
uniprot id: D5UKN2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

446466:CFLA RS13795
gene id: 446466:CFLA_RS13795
uniprot id: D5UJH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

446466:CFLA RS11530
gene id: 446466:CFLA_RS11530
uniprot id: D5UGS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

446466:CFLA RS03290
gene id: 446466:CFLA_RS03290
uniprot id: D5UJ43
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

446466:CFLA RS07815
gene id: 446466:CFLA_RS07815
uniprot id: D5UDA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS04285
gene id: 446466:CFLA_RS04285
uniprot id: D5UK21
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

446466:CFLA RS03085
gene id: 446466:CFLA_RS03085
uniprot id: D5UIM3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446466:CFLA RS11995
gene id: 446466:CFLA_RS11995
uniprot id: D5UHE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS05105
gene id: 446466:CFLA_RS05105
uniprot id: D5UKV2
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

446466:CFLA RS08465
gene id: 446466:CFLA_RS08465
uniprot id: D5UE14
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

446466:CFLA RS02255
gene id: 446466:CFLA_RS02255
uniprot id: D5UHT9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

446466:CFLA RS05185
gene id: 446466:CFLA_RS05185
uniprot id: D5UKW8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

446466:CFLA RS15415
gene id: 446466:CFLA_RS15415
uniprot id: D5UL51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS04125
gene id: 446466:CFLA_RS04125
uniprot id: D5UJY8
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

446466:CFLA RS15615
gene id: 446466:CFLA_RS15615
uniprot id: D5UL92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

446466:CFLA RS04695
gene id: 446466:CFLA_RS04695
uniprot id: D5UKM5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

446466:CFLA RS05585
gene id: 446466:CFLA_RS05585
uniprot id: D5ULG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS12740
gene id: 446466:CFLA_RS12740
uniprot id: D5UI65
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

446466:CFLA RS05035
gene id: 446466:CFLA_RS05035
uniprot id: D5UKT8
names: Similarity
messages: Belongs to the LOG family.

446466:CFLA RS13385
gene id: 446466:CFLA_RS13385
uniprot id: D5UIX2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

446466:CFLA RS06840
gene id: 446466:CFLA_RS06840
uniprot id: D5UCE1
names: Similarity
messages: Belongs to the type IB topoisomerase family.

446466:CFLA RS14210
gene id: 446466:CFLA_RS14210
uniprot id: D5UJQ8
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

446466:CFLA RS15150
gene id: 446466:CFLA_RS15150
uniprot id: D5UKZ8
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

446466:CFLA RS03545
gene id: 446466:CFLA_RS03545
uniprot id: D5UJ91
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS10740
gene id: 446466:CFLA_RS10740
uniprot id: D5UFZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

446466:CFLA RS04685
gene id: 446466:CFLA_RS04685
uniprot id: D5UKM3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

446466:CFLA RS13650
gene id: 446466:CFLA_RS13650
uniprot id: D5UJ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

446466:CFLA RS08480
gene id: 446466:CFLA_RS08480
uniprot id: D5UE17
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS19045
gene id: 446466:CFLA_RS19045
uniprot id: D5UG11
names: Similarity
messages: Belongs to the peptidase C40 family.

446466:CFLA RS04880
gene id: 446466:CFLA_RS04880
uniprot id: D5UKQ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

446466:CFLA RS09220
gene id: 446466:CFLA_RS09220
uniprot id: D5UEQ9
names: Similarity
messages: Belongs to the GSP E family.

446466:CFLA RS09905
gene id: 446466:CFLA_RS09905
uniprot id: D5UF55
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

446466:CFLA RS12635
gene id: 446466:CFLA_RS12635
uniprot id: D5UI44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS14205
gene id: 446466:CFLA_RS14205
uniprot id: D5UJQ7
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS17930
gene id: 446466:CFLA_RS17930
uniprot id: D5UDH9
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

446466:CFLA RS06600
gene id: 446466:CFLA_RS06600
uniprot id: D5UC96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

446466:CFLA RS11050
gene id: 446466:CFLA_RS11050
uniprot id: D5UG50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS09345
gene id: 446466:CFLA_RS09345
uniprot id: D5UET3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS01455
gene id: 446466:CFLA_RS01455
uniprot id: D5UH03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS06060
gene id: 446466:CFLA_RS06060
uniprot id: D5UBK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS10680
gene id: 446466:CFLA_RS10680
uniprot id: D5UFY1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

446466:CFLA RS03140
gene id: 446466:CFLA_RS03140
uniprot id: D5UIN6
names: Similarity
messages: Belongs to the peptidase S13 family.

446466:CFLA RS17395
gene id: 446466:CFLA_RS17395
uniprot id: D5UCU3
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS17000
gene id: 446466:CFLA_RS17000
uniprot id: D5UCL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

446466:CFLA RS08215
gene id: 446466:CFLA_RS08215
uniprot id: D5UDW8
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

446466:CFLA RS20385
gene id: 446466:CFLA_RS20385
uniprot id: D5ULF7
names: Similarity
names: Subunit
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Monomer.

446466:CFLA RS12630
gene id: 446466:CFLA_RS12630
uniprot id: D5UI43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

446466:CFLA RS10730
gene id: 446466:CFLA_RS10730
uniprot id: D5UFZ1
names: Similarity
messages: Belongs to the glutamine synthetase family.

446466:CFLA RS14105
gene id: 446466:CFLA_RS14105
uniprot id: D5UJN6
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

446466:CFLA RS09370
gene id: 446466:CFLA_RS09370
uniprot id: D5UET8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

446466:CFLA RS04235
gene id: 446466:CFLA_RS04235
uniprot id: D5UK10
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

446466:CFLA RS13355
gene id: 446466:CFLA_RS13355
uniprot id: D5UIW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

446466:CFLA RS01010
gene id: 446466:CFLA_RS01010
uniprot id: D5UGD6
names: Similarity
messages: Belongs to the peptidase S45 family.

446466:CFLA RS17850
gene id: 446466:CFLA_RS17850
uniprot id: D5UDG3
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

446466:CFLA RS10530
gene id: 446466:CFLA_RS10530
uniprot id: D5UFV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

446466:CFLA RS07435
gene id: 446466:CFLA_RS07435
uniprot id: D5UD33
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

446466:CFLA RS05020
gene id: 446466:CFLA_RS05020
uniprot id: D5UKT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

446466:CFLA RS06070
gene id: 446466:CFLA_RS06070
uniprot id: D5UBK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446466:CFLA RS10230
gene id: 446466:CFLA_RS10230
uniprot id: D5UFB9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

446466:CFLA RS13475
gene id: 446466:CFLA_RS13475
uniprot id: D5UIZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

446466:CFLA RS05395
gene id: 446466:CFLA_RS05395
uniprot id: D5ULD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

446466:CFLA RS09105
gene id: 446466:CFLA_RS09105
uniprot id: D5UEN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS13465
gene id: 446466:CFLA_RS13465
uniprot id: D5UIY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

446466:CFLA RS13665
gene id: 446466:CFLA_RS13665
uniprot id: D5UJ22
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

446466:CFLA RS07465
gene id: 446466:CFLA_RS07465
uniprot id: D5UD39
names: Similarity
messages: Belongs to the UPF0102 family.

446466:CFLA RS05710
gene id: 446466:CFLA_RS05710
uniprot id: D5ULJ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS12375
gene id: 446466:CFLA_RS12375
uniprot id: D5UHL7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446466:CFLA RS07530
gene id: 446466:CFLA_RS07530
uniprot id: D5UD52
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS04260
gene id: 446466:CFLA_RS04260
uniprot id: D5UK16
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

446466:CFLA RS05880
gene id: 446466:CFLA_RS05880
uniprot id: D5ULM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

446466:CFLA RS05150
gene id: 446466:CFLA_RS05150
uniprot id: D5UKW1
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS17760
gene id: 446466:CFLA_RS17760
uniprot id: D5UDE4
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

446466:CFLA RS13565
gene id: 446466:CFLA_RS13565
uniprot id: D5UJ06
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

446466:CFLA RS12695
gene id: 446466:CFLA_RS12695
uniprot id: D5UI56
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS15025
gene id: 446466:CFLA_RS15025
uniprot id: D5UKJ4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

446466:CFLA RS08575
gene id: 446466:CFLA_RS08575
uniprot id: D5UED4
names: Similarity
messages: Belongs to the thymidine kinase family.

446466:CFLA RS03840
gene id: 446466:CFLA_RS03840
uniprot id: D5UJF1
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

446466:CFLA RS11700
gene id: 446466:CFLA_RS11700
uniprot id: D5UGV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS05645
gene id: 446466:CFLA_RS05645
uniprot id: D5ULH9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

446466:CFLA RS08335
gene id: 446466:CFLA_RS08335
uniprot id: D5UDZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS08770
gene id: 446466:CFLA_RS08770
uniprot id: D5UEH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

446466:CFLA RS07240
gene id: 446466:CFLA_RS07240
uniprot id: D5UCZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS07810
gene id: 446466:CFLA_RS07810
uniprot id: D5UDA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

446466:CFLA RS18500
gene id: 446466:CFLA_RS18500
uniprot id: D5UE73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

446466:CFLA RS08155
gene id: 446466:CFLA_RS08155
uniprot id: D5UDV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

446466:CFLA RS09755
gene id: 446466:CFLA_RS09755
uniprot id: D5UF11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

446466:CFLA RS16775
gene id: 446466:CFLA_RS16775
uniprot id: D5UC47
names: Function
names: Similarity
messages: Belongs to the UPF0677 family.
messages: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.

446466:CFLA RS04230
gene id: 446466:CFLA_RS04230
uniprot id: D5UK09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

446466:CFLA RS03905
gene id: 446466:CFLA_RS03905
uniprot id: D5UJG3
names: Similarity
messages: Belongs to the universal stress protein A family.

446466:CFLA RS07655
gene id: 446466:CFLA_RS07655
uniprot id: D5UD77
names: Similarity
messages: Belongs to the ribF family.

446466:CFLA RS08860
gene id: 446466:CFLA_RS08860
uniprot id: D5UEJ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

446466:CFLA RS05285
gene id: 446466:CFLA_RS05285
uniprot id: D5ULB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

446466:CFLA RS04860
gene id: 446466:CFLA_RS04860
uniprot id: D5UKQ4
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

446466:CFLA RS05170
gene id: 446466:CFLA_RS05170
uniprot id: D5UKW5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

446466:CFLA RS15865
gene id: 446466:CFLA_RS15865
uniprot id: D5ULR7
names: Subcellular Location Annotation
messages: Cytoplasm

446466:CFLA RS03770
gene id: 446466:CFLA_RS03770
uniprot id: D5UJD4
names: Subcellular Location Annotation
messages: Cytoplasm

446466:CFLA RS12810
gene id: 446466:CFLA_RS12810
uniprot id: D5UI79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

446466:CFLA RS12490
gene id: 446466:CFLA_RS12490
uniprot id: D5UI16
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

446466:CFLA RS10455
gene id: 446466:CFLA_RS10455
uniprot id: D5UFG3
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

446466:CFLA RS13755
gene id: 446466:CFLA_RS13755
uniprot id: D5UJ40
names: Similarity
messages: Belongs to the isochorismate synthase family.

446466:CFLA RS14935
gene id: 446466:CFLA_RS14935
uniprot id: D5UKH6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

446466:CFLA RS13445
gene id: 446466:CFLA_RS13445
uniprot id: D5UIY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

446466:CFLA RS12290
gene id: 446466:CFLA_RS12290
uniprot id: D5UHJ9
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

446466:CFLA RS04710
gene id: 446466:CFLA_RS04710
uniprot id: D5UKM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

446466:CFLA RS09830
gene id: 446466:CFLA_RS09830
uniprot id: D5UF26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

446466:CFLA RS14230
gene id: 446466:CFLA_RS14230
uniprot id: D5UJR2
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

446466:CFLA RS04820
gene id: 446466:CFLA_RS04820
uniprot id: D5UKP6
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09015
gene id: 446466:CFLA_RS09015
uniprot id: D5UEL9
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

446466:CFLA RS07600
gene id: 446466:CFLA_RS07600
uniprot id: D5UD66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

446466:CFLA RS06535
gene id: 446466:CFLA_RS06535
uniprot id: D5UBV3
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS00015
gene id: 446466:CFLA_RS00015
uniprot id: D5UF36
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

446466:CFLA RS18805
gene id: 446466:CFLA_RS18805
uniprot id: D5UHX1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS09840
gene id: 446466:CFLA_RS09840
uniprot id: D5UF28
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

446466:CFLA RS12215
gene id: 446466:CFLA_RS12215
uniprot id: D5UHI4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446466:CFLA RS16060
gene id: 446466:CFLA_RS16060
uniprot id: D5ULV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS12380
gene id: 446466:CFLA_RS12380
uniprot id: D5UHL8
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

446466:CFLA RS13295
gene id: 446466:CFLA_RS13295
uniprot id: D5UIV4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

446466:CFLA RS10670
gene id: 446466:CFLA_RS10670
uniprot id: D5UFX9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

446466:CFLA RS14965
gene id: 446466:CFLA_RS14965
uniprot id: D5UKI2
names: Similarity
messages: Belongs to the GARS family.

446466:CFLA RS05340
gene id: 446466:CFLA_RS05340
uniprot id: D5ULC3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

446466:CFLA RS01160
gene id: 446466:CFLA_RS01160
uniprot id: D5UGG6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446466:CFLA RS11085
gene id: 446466:CFLA_RS11085
uniprot id: D5UG57
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

446466:CFLA RS15140
gene id: 446466:CFLA_RS15140
uniprot id: D5UKZ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

446466:CFLA RS04400
gene id: 446466:CFLA_RS04400
uniprot id: D5UK43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS07970
gene id: 446466:CFLA_RS07970
uniprot id: D5UDS0
names: Subcellular Location Annotation
messages: Cytoplasm

446466:CFLA RS02885
gene id: 446466:CFLA_RS02885
uniprot id: D5UII4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

446466:CFLA RS11670
gene id: 446466:CFLA_RS11670
uniprot id: D5UGV0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

446466:CFLA RS11065
gene id: 446466:CFLA_RS11065
uniprot id: D5UG53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS09275
gene id: 446466:CFLA_RS09275
uniprot id: D5UES0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

446466:CFLA RS06270
gene id: 446466:CFLA_RS06270
uniprot id: D5UBP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

446466:CFLA RS02675
gene id: 446466:CFLA_RS02675
uniprot id: D5UIE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

446466:CFLA RS05730
gene id: 446466:CFLA_RS05730
uniprot id: D5ULJ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS00815
gene id: 446466:CFLA_RS00815
uniprot id: D5UG97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

446466:CFLA RS03520
gene id: 446466:CFLA_RS03520
uniprot id: D5UJ86
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

446466:CFLA RS07510
gene id: 446466:CFLA_RS07510
uniprot id: D5UD48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

446466:CFLA RS09980
gene id: 446466:CFLA_RS09980
uniprot id: D5UF70
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13345
gene id: 446466:CFLA_RS13345
uniprot id: D5UIW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

446466:CFLA RS10390
gene id: 446466:CFLA_RS10390
uniprot id: D5UFF0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS00820
gene id: 446466:CFLA_RS00820
uniprot id: D5UG98
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

446466:CFLA RS08690
gene id: 446466:CFLA_RS08690
uniprot id: D5UEF7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

446466:CFLA RS10725
gene id: 446466:CFLA_RS10725
uniprot id: D5UFZ0
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

446466:CFLA RS08380
gene id: 446466:CFLA_RS08380
uniprot id: D5UDZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS04290
gene id: 446466:CFLA_RS04290
uniprot id: D5UK22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

446466:CFLA RS13035
gene id: 446466:CFLA_RS13035
uniprot id: D5UIC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

446466:CFLA RS00010
gene id: 446466:CFLA_RS00010
uniprot id: D5UF35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

446466:CFLA RS08810
gene id: 446466:CFLA_RS08810
uniprot id: D5UEI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

446466:CFLA RS03400
gene id: 446466:CFLA_RS03400
uniprot id: D5UJ65
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

446466:CFLA RS06745
gene id: 446466:CFLA_RS06745
uniprot id: D5UCC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS13775
gene id: 446466:CFLA_RS13775
uniprot id: D5UJH2
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS07280
gene id: 446466:CFLA_RS07280
uniprot id: D5UD03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

446466:CFLA RS02265
gene id: 446466:CFLA_RS02265
uniprot id: D5UHU1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

446466:CFLA RS15225
gene id: 446466:CFLA_RS15225
uniprot id: D5UL13
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

446466:CFLA RS04720
gene id: 446466:CFLA_RS04720
uniprot id: D5UKN0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

446466:CFLA RS11010
gene id: 446466:CFLA_RS11010
uniprot id: D5UG42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

446466:CFLA RS13460
gene id: 446466:CFLA_RS13460
uniprot id: D5UIY7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

446466:CFLA RS15965
gene id: 446466:CFLA_RS15965
uniprot id: D5ULT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

446466:CFLA RS06275
gene id: 446466:CFLA_RS06275
uniprot id: D5UBQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

446466:CFLA RS18655
gene id: 446466:CFLA_RS18655
uniprot id: D5UEA3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS07745
gene id: 446466:CFLA_RS07745
uniprot id: D5UD95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

446466:CFLA RS06100
gene id: 446466:CFLA_RS06100
uniprot id: D5UBL5
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13420
gene id: 446466:CFLA_RS13420
uniprot id: D5UIX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

446466:CFLA RS12335
gene id: 446466:CFLA_RS12335
uniprot id: D5UHK9
names: Similarity
messages: Belongs to the Fur family.

446466:CFLA RS12660
gene id: 446466:CFLA_RS12660
uniprot id: D5UI49
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS03205
gene id: 446466:CFLA_RS03205
uniprot id: D5UIP9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

446466:CFLA RS12615
gene id: 446466:CFLA_RS12615
uniprot id: D5UI40
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09785
gene id: 446466:CFLA_RS09785
uniprot id: D5UF17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

446466:CFLA RS13880
gene id: 446466:CFLA_RS13880
uniprot id: D5UJJ4
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS01135
gene id: 446466:CFLA_RS01135
uniprot id: D5UGG1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS01220
gene id: 446466:CFLA_RS01220
uniprot id: D5UGH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the faeC family.
messages: Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.
messages: Secreted

446466:CFLA RS05055
gene id: 446466:CFLA_RS05055
uniprot id: D5UKU2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

446466:CFLA RS07865
gene id: 446466:CFLA_RS07865
uniprot id: D5UDP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS18140
gene id: 446466:CFLA_RS18140
uniprot id: D5UDL9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

446466:CFLA RS06265
gene id: 446466:CFLA_RS06265
uniprot id: D5UBP8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

446466:CFLA RS00825
gene id: 446466:CFLA_RS00825
uniprot id: D5UG99
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

446466:CFLA RS18615
gene id: 446466:CFLA_RS18615
uniprot id: D5UE95
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

446466:CFLA RS12855
gene id: 446466:CFLA_RS12855
uniprot id: D5UI88
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS18625
gene id: 446466:CFLA_RS18625
uniprot id: D5UE97
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS03395
gene id: 446466:CFLA_RS03395
uniprot id: D5UJ64
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

446466:CFLA RS09430
gene id: 446466:CFLA_RS09430
uniprot id: D5UEV0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

446466:CFLA RS13270
gene id: 446466:CFLA_RS13270
uniprot id: D5UIU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

446466:CFLA RS13645
gene id: 446466:CFLA_RS13645
uniprot id: D5UJ18
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

446466:CFLA RS13210
gene id: 446466:CFLA_RS13210
uniprot id: D5UIT8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

446466:CFLA RS08425
gene id: 446466:CFLA_RS08425
uniprot id: D5UE06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS18300
gene id: 446466:CFLA_RS18300
uniprot id: D5UE31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

446466:CFLA RS08640
gene id: 446466:CFLA_RS08640
uniprot id: D5UEE7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

446466:CFLA RS03540
gene id: 446466:CFLA_RS03540
uniprot id: D5UJ90
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13515
gene id: 446466:CFLA_RS13515
uniprot id: D5UIZ8
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

446466:CFLA RS13610
gene id: 446466:CFLA_RS13610
uniprot id: D5UJ14
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

446466:CFLA RS09845
gene id: 446466:CFLA_RS09845
uniprot id: D5UF29
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

446466:CFLA RS11305
gene id: 446466:CFLA_RS11305
uniprot id: D5UGM7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS11025
gene id: 446466:CFLA_RS11025
uniprot id: D5UG45
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446466:CFLA RS01835
gene id: 446466:CFLA_RS01835
uniprot id: D5UH76
names: Similarity
messages: Belongs to the CsoR family.

446466:CFLA RS09955
gene id: 446466:CFLA_RS09955
uniprot id: D5UF65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

446466:CFLA RS02355
gene id: 446466:CFLA_RS02355
uniprot id: D5UHW0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09080
gene id: 446466:CFLA_RS09080
uniprot id: D5UEN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

446466:CFLA RS14840
gene id: 446466:CFLA_RS14840
uniprot id: D5UKF7
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

446466:CFLA RS02755
gene id: 446466:CFLA_RS02755
uniprot id: D5UIG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

446466:CFLA RS09005
gene id: 446466:CFLA_RS09005
uniprot id: D5UEL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

446466:CFLA RS14650
gene id: 446466:CFLA_RS14650
uniprot id: D5UKC2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS11280
gene id: 446466:CFLA_RS11280
uniprot id: D5UGM2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS15085
gene id: 446466:CFLA_RS15085
uniprot id: D5UKY5
names: Similarity
messages: Belongs to the glycosyl hydrolase 67 family.

446466:CFLA RS10325
gene id: 446466:CFLA_RS10325
uniprot id: D5UFD7
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

446466:CFLA RS08300
gene id: 446466:CFLA_RS08300
uniprot id: D5UDY5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

446466:CFLA RS07885
gene id: 446466:CFLA_RS07885
uniprot id: D5UDQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

446466:CFLA RS07610
gene id: 446466:CFLA_RS07610
uniprot id: D5UD68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

446466:CFLA RS00675
gene id: 446466:CFLA_RS00675
uniprot id: D5UFU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

446466:CFLA RS14770
gene id: 446466:CFLA_RS14770
uniprot id: D5UKE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

446466:CFLA RS04700
gene id: 446466:CFLA_RS04700
uniprot id: D5UKM6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

446466:CFLA RS13190
gene id: 446466:CFLA_RS13190
uniprot id: D5UIT4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

446466:CFLA RS15090
gene id: 446466:CFLA_RS15090
uniprot id: D5UKY6
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

446466:CFLA RS00590
gene id: 446466:CFLA_RS00590
uniprot id: D5UFS7
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS09385
gene id: 446466:CFLA_RS09385
uniprot id: D5UEU1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS01335
gene id: 446466:CFLA_RS01335
uniprot id: D5UGY0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

446466:CFLA RS02125
gene id: 446466:CFLA_RS02125
uniprot id: D5UHR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

446466:CFLA RS04545
gene id: 446466:CFLA_RS04545
uniprot id: D5UK72
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

446466:CFLA RS07475
gene id: 446466:CFLA_RS07475
uniprot id: D5UD41
names: Similarity
messages: Belongs to the DprA/Smf family.

446466:CFLA RS16370
gene id: 446466:CFLA_RS16370
uniprot id: D5UBW7
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

446466:CFLA RS09395
gene id: 446466:CFLA_RS09395
uniprot id: D5UEU3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

446466:CFLA RS13140
gene id: 446466:CFLA_RS13140
uniprot id: D5UIS4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS01145
gene id: 446466:CFLA_RS01145
uniprot id: D5UGG3
names: Similarity
messages: Belongs to the YciI family.

446466:CFLA RS10920
gene id: 446466:CFLA_RS10920
uniprot id: D5UG28
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

446466:CFLA RS03530
gene id: 446466:CFLA_RS03530
uniprot id: D5UJ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm

446466:CFLA RS04840
gene id: 446466:CFLA_RS04840
uniprot id: D5UKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446466:CFLA RS06670
gene id: 446466:CFLA_RS06670
uniprot id: D5UCB1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

446466:CFLA RS09800
gene id: 446466:CFLA_RS09800
uniprot id: D5UF20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

446466:CFLA RS10255
gene id: 446466:CFLA_RS10255
uniprot id: D5UFC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

446466:CFLA RS04920
gene id: 446466:CFLA_RS04920
uniprot id: D5UKR5
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

446466:CFLA RS10535
gene id: 446466:CFLA_RS10535
uniprot id: D5UFV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

446466:CFLA RS09805
gene id: 446466:CFLA_RS09805
uniprot id: D5UF21
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS11160
gene id: 446466:CFLA_RS11160
uniprot id: D5UG72
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS14195
gene id: 446466:CFLA_RS14195
uniprot id: D5UJQ5
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS11375
gene id: 446466:CFLA_RS11375
uniprot id: D5UGP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

446466:CFLA RS09230
gene id: 446466:CFLA_RS09230
uniprot id: D5UER1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS11975
gene id: 446466:CFLA_RS11975
uniprot id: D5UHD6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS14755
gene id: 446466:CFLA_RS14755
uniprot id: D5UKD9
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

446466:CFLA RS05655
gene id: 446466:CFLA_RS05655
uniprot id: D5ULI1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

446466:CFLA RS03865
gene id: 446466:CFLA_RS03865
uniprot id: D5UJF5
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS13425
gene id: 446466:CFLA_RS13425
uniprot id: D5UIY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

446466:CFLA RS13770
gene id: 446466:CFLA_RS13770
uniprot id: D5UJH1
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

446466:CFLA RS17465
gene id: 446466:CFLA_RS17465
uniprot id: D5UCV8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS07505
gene id: 446466:CFLA_RS07505
uniprot id: D5UD47
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS03055
gene id: 446466:CFLA_RS03055
uniprot id: D5UIL7
names: Similarity
messages: Belongs to the UPF0045 family.

446466:CFLA RS13370
gene id: 446466:CFLA_RS13370
uniprot id: D5UIW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

446466:CFLA RS07720
gene id: 446466:CFLA_RS07720
uniprot id: D5UD90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

446466:CFLA RS09620
gene id: 446466:CFLA_RS09620
uniprot id: D5UEY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

446466:CFLA RS09860
gene id: 446466:CFLA_RS09860
uniprot id: D5UF32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

446466:CFLA RS12285
gene id: 446466:CFLA_RS12285
uniprot id: D5UHJ8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

446466:CFLA RS01595
gene id: 446466:CFLA_RS01595
uniprot id: D5UH30
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

446466:CFLA RS08870
gene id: 446466:CFLA_RS08870
uniprot id: D5UEJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

446466:CFLA RS09690
gene id: 446466:CFLA_RS09690
uniprot id: D5UF02
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

446466:CFLA RS09325
gene id: 446466:CFLA_RS09325
uniprot id: D5UES9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

446466:CFLA RS08505
gene id: 446466:CFLA_RS08505
uniprot id: D5UE22
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS15780
gene id: 446466:CFLA_RS15780
uniprot id: D5ULQ1
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

446466:CFLA RS08125
gene id: 446466:CFLA_RS08125
uniprot id: D5UDV1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

446466:CFLA RS00670
gene id: 446466:CFLA_RS00670
uniprot id: D5UFU3
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

446466:CFLA RS05325
gene id: 446466:CFLA_RS05325
uniprot id: D5ULC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

446466:CFLA RS13255
gene id: 446466:CFLA_RS13255
uniprot id: D5UIU6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

446466:CFLA RS11535
gene id: 446466:CFLA_RS11535
uniprot id: D5UGS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

446466:CFLA RS11055
gene id: 446466:CFLA_RS11055
uniprot id: D5UG51
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

446466:CFLA RS13040
gene id: 446466:CFLA_RS13040
uniprot id: D5UIC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

446466:CFLA RS18675
gene id: 446466:CFLA_RS18675
uniprot id: D5UEA7
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS02495
gene id: 446466:CFLA_RS02495
uniprot id: D5UHY6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS11765
gene id: 446466:CFLA_RS11765
uniprot id: D5UGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

446466:CFLA RS12065
gene id: 446466:CFLA_RS12065
uniprot id: D5UHF4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

446466:CFLA RS09565
gene id: 446466:CFLA_RS09565
uniprot id: D5UEX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

446466:CFLA RS04425
gene id: 446466:CFLA_RS04425
uniprot id: D5UK48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

446466:CFLA RS09180
gene id: 446466:CFLA_RS09180
uniprot id: D5UEQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

446466:CFLA RS09465
gene id: 446466:CFLA_RS09465
uniprot id: D5UEV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

446466:CFLA RS18855
gene id: 446466:CFLA_RS18855
uniprot id: D5UJ83
names: Similarity
messages: Belongs to the UreD family.

446466:CFLA RS18130
gene id: 446466:CFLA_RS18130
uniprot id: D5UDL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GmhB family.
messages: Cytoplasm

446466:CFLA RS00940
gene id: 446466:CFLA_RS00940
uniprot id: D5UGC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

446466:CFLA RS17535
gene id: 446466:CFLA_RS17535
uniprot id: D5UCX2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS10635
gene id: 446466:CFLA_RS10635
uniprot id: D5UFX2
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

446466:CFLA RS15450
gene id: 446466:CFLA_RS15450
uniprot id: D5UL59
names: Similarity
messages: Belongs to the TelA family.

446466:CFLA RS12050
gene id: 446466:CFLA_RS12050
uniprot id: D5UHF1
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

446466:CFLA RS08925
gene id: 446466:CFLA_RS08925
uniprot id: D5UEK5
names: Similarity
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Homotrimer.

446466:CFLA RS10890
gene id: 446466:CFLA_RS10890
uniprot id: D5UG22
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

446466:CFLA RS13605
gene id: 446466:CFLA_RS13605
uniprot id: D5UJ13
names: Similarity
messages: Belongs to the UPF0336 family.

446466:CFLA RS13220
gene id: 446466:CFLA_RS13220
uniprot id: D5UIU0
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS02430
gene id: 446466:CFLA_RS02430
uniprot id: D5UHX5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

446466:CFLA RS06260
gene id: 446466:CFLA_RS06260
uniprot id: D5UBP7
names: Similarity
messages: Belongs to the universal stress protein A family.

446466:CFLA RS00665
gene id: 446466:CFLA_RS00665
uniprot id: D5UFU2
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS15045
gene id: 446466:CFLA_RS15045
uniprot id: D5UKJ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS09375
gene id: 446466:CFLA_RS09375
uniprot id: D5UET9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446466:CFLA RS01990
gene id: 446466:CFLA_RS01990
uniprot id: D5UHN8
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

446466:CFLA RS04505
gene id: 446466:CFLA_RS04505
uniprot id: D5UK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

446466:CFLA RS07630
gene id: 446466:CFLA_RS07630
uniprot id: D5UD72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

446466:CFLA RS00070
gene id: 446466:CFLA_RS00070
uniprot id: D5UF46
names: Subcellular Location Annotation
messages: Cytoplasm

446466:CFLA RS17725
gene id: 446466:CFLA_RS17725
uniprot id: D5UDD6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446466:CFLA RS19150
gene id: 446466:CFLA_RS19150
uniprot id: D5UK79
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS06570
gene id: 446466:CFLA_RS06570
uniprot id: D5UC91
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

446466:CFLA RS18695
gene id: 446466:CFLA_RS18695
uniprot id: D5UEB1
names: Similarity
messages: Belongs to the ParB family.

446466:CFLA RS07480
gene id: 446466:CFLA_RS07480
uniprot id: D5UD42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

446466:CFLA RS05970
gene id: 446466:CFLA_RS05970
uniprot id: D5UBI9
names: Subcellular Location Annotation
messages: Membrane

446466:CFLA RS14730
gene id: 446466:CFLA_RS14730
uniprot id: D5UKD4
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

446466:CFLA RS08835
gene id: 446466:CFLA_RS08835
uniprot id: D5UEI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

446466:CFLA RS04715
gene id: 446466:CFLA_RS04715
uniprot id: D5UKM9
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.