431947:PGN RS08845
gene id: 431947:PGN_RS08845
uniprot id: B2RLY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

431947:PGN RS02065
gene id: 431947:PGN_RS02065
uniprot id: B2RHV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

431947:PGN RS05410
gene id: 431947:PGN_RS05410
uniprot id: B2RJV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

431947:PGN RS06910
gene id: 431947:PGN_RS06910
uniprot id: B2RKS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

431947:PGN RS05320
gene id: 431947:PGN_RS05320
uniprot id: B2RJT5
names: Caution
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS08855
gene id: 431947:PGN_RS08855
uniprot id: B2RLZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

431947:PGN RS08410
gene id: 431947:PGN_RS08410
uniprot id: B2RLP5
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

431947:PGN RS08075
gene id: 431947:PGN_RS08075
uniprot id: B2RLH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

431947:PGN RS03060
gene id: 431947:PGN_RS03060
uniprot id: B2RIG5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

431947:PGN RS02405
gene id: 431947:PGN_RS02405
uniprot id: B2RI28
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

431947:PGN RS09890
gene id: 431947:PGN_RS09890
uniprot id: B2RMK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

431947:PGN RS03945
gene id: 431947:PGN_RS03945
uniprot id: B2RJ01
names: Activity Regulation
names: Function
names: Similarity
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.

431947:PGN RS01375
gene id: 431947:PGN_RS01375
uniprot id: B2RHG1
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacteroidetes fimbrillin superfamily.
messages: Cell outer membrane
messages: Fimbrium
messages: Mfa1-deficient cells show increased autoaggregation. Double mutants lacking both FimA and Mfa1 lack major and minor fimbriae; they fail to adhere to host cells.
messages: Structural component of the fimbrial stalk. Minor fimbriae are composed of a structural subunit, most often Mfa1, and the accessory subunits Mfa3, Mfa4 and Mfa5 (PubMed:19589838, PubMed:24118823, PubMed:26001707, PubMed:26437277). Mfa1 interacts with Mfa2; this anchors the fimbrium in the membrane (PubMed:19589838). Fimbrium assembly occurs by linear, head-to-tail oligomerization of fimbrial subunits. This is mediated via insertion of a C-terminal beta-strand from one subunit into a groove in the N-terminal domain of the following subunit (Probable). Interacts with S.gordonii ssp5 (PubMed:11083792, PubMed:15972485).
messages: Structural subunit of the minor fimbriae (PubMed:12593606, PubMed:19589838, PubMed:24118823). These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:11083792, PubMed:12593606, PubMed:15972485, PubMed:19589838, PubMed:23809984, PubMed:24118823, PubMed:26001707, PubMed:26437277). They play an important role in invasion of periodontal tissues and are recognized as major virulence factors. Mfa1 orthologs from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).
messages: The name (minor fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.

431947:PGN RS03005
gene id: 431947:PGN_RS03005
uniprot id: B2RIF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

431947:PGN RS05895
gene id: 431947:PGN_RS05895
uniprot id: B2RK50
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

431947:PGN RS04005
gene id: 431947:PGN_RS04005
uniprot id: B2RJ14
names: Similarity
messages: Belongs to the XseB family.

431947:PGN RS05645
gene id: 431947:PGN_RS05645
uniprot id: B2RK00
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

431947:PGN RS03325
gene id: 431947:PGN_RS03325
uniprot id: B2RIM0
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

431947:PGN RS07510
gene id: 431947:PGN_RS07510
uniprot id: B2RL51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

431947:PGN RS01125
gene id: 431947:PGN_RS01125
uniprot id: B2RHA8
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

431947:PGN RS08445
gene id: 431947:PGN_RS08445
uniprot id: B2RLQ4
names: Similarity
messages: Belongs to the RutC family.

431947:PGN RS01185
gene id: 431947:PGN_RS01185
uniprot id: B2RHC0
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS03535
gene id: 431947:PGN_RS03535
uniprot id: B2RIR6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

431947:PGN RS08810
gene id: 431947:PGN_RS08810
uniprot id: B2RLY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

431947:PGN RS00085
gene id: 431947:PGN_RS00085
uniprot id: B2RGP0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

431947:PGN RS01970
gene id: 431947:PGN_RS01970
uniprot id: B2RHT7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

431947:PGN RS05180
gene id: 431947:PGN_RS05180
uniprot id: B2RJQ4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

431947:PGN RS06830
gene id: 431947:PGN_RS06830
uniprot id: B2RKQ7
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS02060
gene id: 431947:PGN_RS02060
uniprot id: B2RHV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

431947:PGN RS00645
gene id: 431947:PGN_RS00645
uniprot id: B2RH11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS03035
gene id: 431947:PGN_RS03035
uniprot id: B2RIG0
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

431947:PGN RS06935
gene id: 431947:PGN_RS06935
uniprot id: B2RKS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

431947:PGN RS02380
gene id: 431947:PGN_RS02380
uniprot id: B2RI23
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

431947:PGN RS00470
gene id: 431947:PGN_RS00470
uniprot id: B2RGX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

431947:PGN RS02610
gene id: 431947:PGN_RS02610
uniprot id: B2RI72
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

431947:PGN RS04235
gene id: 431947:PGN_RS04235
uniprot id: B2RJ60
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS09565
gene id: 431947:PGN_RS09565
uniprot id: B2RME4
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

431947:PGN RS04140
gene id: 431947:PGN_RS04140
uniprot id: B2RJ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

431947:PGN RS07475
gene id: 431947:PGN_RS07475
uniprot id: B2RL44
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

431947:PGN RS06105
gene id: 431947:PGN_RS06105
uniprot id: B2RGX8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS09360
gene id: 431947:PGN_RS09360
uniprot id: B2RMA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

431947:PGN RS05020
gene id: 431947:PGN_RS05020
uniprot id: B2RJM0
names: Similarity
messages: Belongs to the UPF0758 family.

431947:PGN RS07080
gene id: 431947:PGN_RS07080
uniprot id: B2RKV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

431947:PGN RS03795
gene id: 431947:PGN_RS03795
uniprot id: B2RIW9
names: Similarity
messages: Belongs to the peptidase C25 family.

431947:PGN RS09420
gene id: 431947:PGN_RS09420
uniprot id: B2RMB4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

431947:PGN RS08125
gene id: 431947:PGN_RS08125
uniprot id: B2RLI2
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

431947:PGN RS03195
gene id: 431947:PGN_RS03195
uniprot id: B2RIJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

431947:PGN RS05390
gene id: 431947:PGN_RS05390
uniprot id: B2RJU9
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS03620
gene id: 431947:PGN_RS03620
uniprot id: B2RIT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

431947:PGN RS00670
gene id: 431947:PGN_RS00670
uniprot id: B2RH16
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS07550
gene id: 431947:PGN_RS07550
uniprot id: B2RL56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

431947:PGN RS03490
gene id: 431947:PGN_RS03490
uniprot id: B2RIQ7
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

431947:PGN RS08860
gene id: 431947:PGN_RS08860
uniprot id: B2RLZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

431947:PGN RS04545
gene id: 431947:PGN_RS04545
uniprot id: B2RJC6
names: Similarity
messages: Belongs to the peptidase S41A family.

431947:PGN RS08230
gene id: 431947:PGN_RS08230
uniprot id: B2RLK7
names: Similarity
messages: Belongs to the peptidase C25 family.

431947:PGN RS02135
gene id: 431947:PGN_RS02135
uniprot id: B2RHW9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

431947:PGN RS03435
gene id: 431947:PGN_RS03435
uniprot id: B2RIP4
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS00975
gene id: 431947:PGN_RS00975
uniprot id: B2RH82
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

431947:PGN RS05025
gene id: 431947:PGN_RS05025
uniprot id: B2RJM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

431947:PGN RS04960
gene id: 431947:PGN_RS04960
uniprot id: B2RJK9
names: Similarity
messages: Belongs to the UPF0597 family.

431947:PGN RS03165
gene id: 431947:PGN_RS03165
uniprot id: B2RII9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

431947:PGN RS00195
gene id: 431947:PGN_RS00195
uniprot id: B2RGR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

431947:PGN RS08375
gene id: 431947:PGN_RS08375
uniprot id: B2RLN6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

431947:PGN RS03675
gene id: 431947:PGN_RS03675
uniprot id: B2RIU5
names: Similarity
messages: Belongs to the peptidase C40 family.

431947:PGN RS03025
gene id: 431947:PGN_RS03025
uniprot id: B2RIF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

431947:PGN RS04010
gene id: 431947:PGN_RS04010
uniprot id: B2RJ15
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

431947:PGN RS05710
gene id: 431947:PGN_RS05710
uniprot id: B2RK14
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

431947:PGN RS06000
gene id: 431947:PGN_RS06000
uniprot id: B2RK76
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

431947:PGN RS06265
gene id: 431947:PGN_RS06265
uniprot id: B2RKD5
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS06325
gene id: 431947:PGN_RS06325
uniprot id: B2RKE8
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS06530
gene id: 431947:PGN_RS06530
uniprot id: B2RKJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Cell surface
messages: Homohexamer.
messages: Probably involved in degradation rather than biosynthesis of glutamate.

431947:PGN RS02875
gene id: 431947:PGN_RS02875
uniprot id: B2RIC6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS04975
gene id: 431947:PGN_RS04975
uniprot id: B2RJL2
names: Similarity
messages: Belongs to the pyruvoyl-dependent arginine decarboxylase family.

431947:PGN RS01170
gene id: 431947:PGN_RS01170
uniprot id: B2RHB7
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

431947:PGN RS07335
gene id: 431947:PGN_RS07335
uniprot id: B2RL11
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

431947:PGN RS03140
gene id: 431947:PGN_RS03140
uniprot id: B2RII4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

431947:PGN RS05655
gene id: 431947:PGN_RS05655
uniprot id: B2RK02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

431947:PGN RS02310
gene id: 431947:PGN_RS02310
uniprot id: B2RI07
names: Similarity
messages: Belongs to the aldose epimerase family.

431947:PGN RS06580
gene id: 431947:PGN_RS06580
uniprot id: B2RKK5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

431947:PGN RS01210
gene id: 431947:PGN_RS01210
uniprot id: B2RHC5
names: Similarity
messages: Belongs to the fabD family.

431947:PGN RS06710
gene id: 431947:PGN_RS06710
uniprot id: B2RKM7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

431947:PGN RS03240
gene id: 431947:PGN_RS03240
uniprot id: B2RIK4
names: Similarity
messages: Belongs to the peptidase S49 family.

431947:PGN RS04780
gene id: 431947:PGN_RS04780
uniprot id: B2RJH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

431947:PGN RS07015
gene id: 431947:PGN_RS07015
uniprot id: B2RKU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

431947:PGN RS00455
gene id: 431947:PGN_RS00455
uniprot id: B2RGX0
names: Similarity
messages: Belongs to the aspartokinase family.

431947:PGN RS08890
gene id: 431947:PGN_RS08890
uniprot id: B2RLZ8
names: Similarity
messages: Belongs to the EPSP synthase family.

431947:PGN RS06390
gene id: 431947:PGN_RS06390
uniprot id: B2RKG2
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

431947:PGN RS01405
gene id: 431947:PGN_RS01405
uniprot id: B2RHG8
names: Similarity
messages: Belongs to the SusD family.

431947:PGN RS07645
gene id: 431947:PGN_RS07645
uniprot id: B2RL77
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

431947:PGN RS01625
gene id: 431947:PGN_RS01625
uniprot id: B2RHL4
names: Similarity
messages: Belongs to the peptidase S41A family.

431947:PGN RS02585
gene id: 431947:PGN_RS02585
uniprot id: B2RI67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

431947:PGN RS04265
gene id: 431947:PGN_RS04265
uniprot id: B2RJ67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

431947:PGN RS08270
gene id: 431947:PGN_RS08270
uniprot id: B2RLL5
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS09625
gene id: 431947:PGN_RS09625
uniprot id: B2RMF6
names: Similarity
messages: Belongs to the DEAD box helicase family.

431947:PGN RS06330
gene id: 431947:PGN_RS06330
uniprot id: B2RKE9
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS06085
gene id: 431947:PGN_RS06085
uniprot id: B2RGX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

431947:PGN RS08185
gene id: 431947:PGN_RS08185
uniprot id: B2RLJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

431947:PGN RS07105
gene id: 431947:PGN_RS07105
uniprot id: B2RKW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the precorrin methyltransferase family.
messages: Homodimer.
messages: Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway.

431947:PGN RS04845
gene id: 431947:PGN_RS04845
uniprot id: B2RJI6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

431947:PGN RS07090
gene id: 431947:PGN_RS07090
uniprot id: B2RKW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

431947:PGN RS08465
gene id: 431947:PGN_RS08465
uniprot id: B2RLQ8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS02695
gene id: 431947:PGN_RS02695
uniprot id: B2RI93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

431947:PGN RS03670
gene id: 431947:PGN_RS03670
uniprot id: B2RIU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

431947:PGN RS05240
gene id: 431947:PGN_RS05240
uniprot id: B2RJR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

431947:PGN RS07990
gene id: 431947:PGN_RS07990
uniprot id: B2RLF3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

431947:PGN RS07520
gene id: 431947:PGN_RS07520
uniprot id: B2RL52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

431947:PGN RS04605
gene id: 431947:PGN_RS04605
uniprot id: B2RJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

431947:PGN RS08315
gene id: 431947:PGN_RS08315
uniprot id: B2RLM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

431947:PGN RS07075
gene id: 431947:PGN_RS07075
uniprot id: B2RKV8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

431947:PGN RS09010
gene id: 431947:PGN_RS09010
uniprot id: B2RH84
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS05775
gene id: 431947:PGN_RS05775
uniprot id: B2RK25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

431947:PGN RS00050
gene id: 431947:PGN_RS00050
uniprot id: B2RGN3
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

431947:PGN RS08415
gene id: 431947:PGN_RS08415
uniprot id: B2RLP6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Belongs to the peptidase C25 family.

431947:PGN RS06040
gene id: 431947:PGN_RS06040
uniprot id: B2RK85
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

431947:PGN RS03375
gene id: 431947:PGN_RS03375
uniprot id: B2RIN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

431947:PGN RS06885
gene id: 431947:PGN_RS06885
uniprot id: B2RKR5
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

431947:PGN RS05570
gene id: 431947:PGN_RS05570
uniprot id: B2RJY5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS08370
gene id: 431947:PGN_RS08370
uniprot id: B2RLN5
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

431947:PGN RS00005
gene id: 431947:PGN_RS00005
uniprot id: B2RGM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

431947:PGN RS07940
gene id: 431947:PGN_RS07940
uniprot id: B2RLE3
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS02895
gene id: 431947:PGN_RS02895
uniprot id: B2RID1
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Shows a strict specificity for acidic residues (Asp or Glu) in the P1 position, and has a hydrophobic residue preference at the P2 position. Preferentially cleaves the synthetic substrate Leu-Asp-methylcoumaryl-7-amide (Leu-Asp-MCA) as compared to Leu-Glu-MCA. Is involved in amino acid metabolism and bacterial growth of asaccharolytic P.gingivalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources.
messages: Cell growth is retarded. Complete loss of hydrolysis for ac-DNLD- and LE-MCA. The efficiency of peptide utilization of proteinaceous nutrients is reduced in mutant cells.
messages: Cell surface
messages: Enzyme activity is completely blocked by diisopropyl-fluorophosphates, moderately by phenylmethylsulfonyl fluoride (PMSF) and 4-(2-methyl)benzenesulfonyl fluoride, and slightly by pepstatin in vitro.
messages: Homodimer.

431947:PGN RS05370
gene id: 431947:PGN_RS05370
uniprot id: B2RJU5
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

431947:PGN RS07885
gene id: 431947:PGN_RS07885
uniprot id: B2RLD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

431947:PGN RS08820
gene id: 431947:PGN_RS08820
uniprot id: B2RLY4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

431947:PGN RS00845
gene id: 431947:PGN_RS00845
uniprot id: B2RH57
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.
messages: Cell outer membrane
messages: Fimbriae are composed of a major, structural subunit and the minor components FimC, FimD and FimE (PubMed:17526848). Identified in a complex composed of FimC, FimD and FimE (in vitro) (PubMed:19506009). The complex interacts with host extracellular matrix proteins, including fibronectin and type I collagen (PubMed:17526848, PubMed:19506009). Interacts with host CXCR4 (PubMed:19506009).
messages: Fimbrium
messages: Minor component of fimbriae (PubMed:17526848). These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:17526848, PubMed:19506009). They play an important role in invasion of periodontal tissues and are major virulence factors (Probable). FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response (PubMed:19506009).
messages: The name (major fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
messages: Triple mutants lacking FimC, FimD and FimE show strongly decreased interaction with host CXCR4 and impaired down-regulation of the TLR2-mediated innate immune response, resulting in strongly reduced survival of the bacteria.

431947:PGN RS05630
gene id: 431947:PGN_RS05630
uniprot id: B2RJZ7
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

431947:PGN RS09270
gene id: 431947:PGN_RS09270
uniprot id: B2RM83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

431947:PGN RS06965
gene id: 431947:PGN_RS06965
uniprot id: B2RKT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

431947:PGN RS08355
gene id: 431947:PGN_RS08355
uniprot id: B2RLN2
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS07810
gene id: 431947:PGN_RS07810
uniprot id: B2RLB6
names: Similarity
messages: Belongs to the peptidase C25 family.

431947:PGN RS08770
gene id: 431947:PGN_RS08770
uniprot id: B2RLX4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

431947:PGN RS07560
gene id: 431947:PGN_RS07560
uniprot id: B2RL59
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

431947:PGN RS08850
gene id: 431947:PGN_RS08850
uniprot id: B2RLZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

431947:PGN RS09775
gene id: 431947:PGN_RS09775
uniprot id: B2RMI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS08475
gene id: 431947:PGN_RS08475
uniprot id: B2RLR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

431947:PGN RS09390
gene id: 431947:PGN_RS09390
uniprot id: B2RMA8
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

431947:PGN RS00805
gene id: 431947:PGN_RS00805
uniprot id: B2RH47
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

431947:PGN RS02690
gene id: 431947:PGN_RS02690
uniprot id: B2RI92
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

431947:PGN RS04745
gene id: 431947:PGN_RS04745
uniprot id: B2RJG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

431947:PGN RS03965
gene id: 431947:PGN_RS03965
uniprot id: B2RJ05
names: Similarity
messages: Belongs to the NusB family.

431947:PGN RS09620
gene id: 431947:PGN_RS09620
uniprot id: B2RMF5
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Belongs to the peptidase C25 family.

431947:PGN RS08150
gene id: 431947:PGN_RS08150
uniprot id: B2RLI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

431947:PGN RS05800
gene id: 431947:PGN_RS05800
uniprot id: B2RK30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

431947:PGN RS03585
gene id: 431947:PGN_RS03585
uniprot id: B2RIS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

431947:PGN RS04715
gene id: 431947:PGN_RS04715
uniprot id: B2RJF8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

431947:PGN RS07930
gene id: 431947:PGN_RS07930
uniprot id: B2RLE1
names: Similarity
messages: Belongs to the DprA/Smf family.

431947:PGN RS04320
gene id: 431947:PGN_RS04320
uniprot id: B2RJ80
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

431947:PGN RS08100
gene id: 431947:PGN_RS08100
uniprot id: B2RLH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

431947:PGN RS07845
gene id: 431947:PGN_RS07845
uniprot id: B2RLC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

431947:PGN RS08110
gene id: 431947:PGN_RS08110
uniprot id: B2RLH9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

431947:PGN RS08835
gene id: 431947:PGN_RS08835
uniprot id: B2RLY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

431947:PGN RS06485
gene id: 431947:PGN_RS06485
uniprot id: B2RKI3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
messages: Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS03010
gene id: 431947:PGN_RS03010
uniprot id: B2RIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

431947:PGN RS03600
gene id: 431947:PGN_RS03600
uniprot id: B2RIT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Prefers Ala and hydrophobic residues except Pro at the P1 position, and has no preference for P2 residues. Shows high dipeptidyl peptidase activity toward the synthetic substrates Lys-Ala-, Gly-Phe-, Met-Leu-, and Ser-Tyr-methylcoumaryl-7-amide (MCA), and slowly hydrolyzes Val-Tyr-MCA. Is likely involved in amino acid metabolism and bacterial growth of asaccharolytic P.gingivalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources.
messages: Homodimer.
messages: Periplasm

431947:PGN RS06400
gene id: 431947:PGN_RS06400
uniprot id: B2RKG5
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

431947:PGN RS07275
gene id: 431947:PGN_RS07275
uniprot id: B2RKZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

431947:PGN RS09815
gene id: 431947:PGN_RS09815
uniprot id: B2RMJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

431947:PGN RS09525
gene id: 431947:PGN_RS09525
uniprot id: B2RMD5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

431947:PGN RS02880
gene id: 431947:PGN_RS02880
uniprot id: B2RIC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

431947:PGN RS07790
gene id: 431947:PGN_RS07790
uniprot id: B2RLB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

431947:PGN RS08225
gene id: 431947:PGN_RS08225
uniprot id: B2RLK4
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS01720
gene id: 431947:PGN_RS01720
uniprot id: B2RHN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS00740
gene id: 431947:PGN_RS00740
uniprot id: B2RH32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

431947:PGN RS01925
gene id: 431947:PGN_RS01925
uniprot id: B2RHS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

431947:PGN RS08915
gene id: 431947:PGN_RS08915
uniprot id: B2RM04
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

431947:PGN RS02955
gene id: 431947:PGN_RS02955
uniprot id: B2RIE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

431947:PGN RS08500
gene id: 431947:PGN_RS08500
uniprot id: B2RLR5
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

431947:PGN RS01195
gene id: 431947:PGN_RS01195
uniprot id: B2RHC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

431947:PGN RS08795
gene id: 431947:PGN_RS08795
uniprot id: B2RLX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

431947:PGN RS07570
gene id: 431947:PGN_RS07570
uniprot id: B2RL62
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

431947:PGN RS08985
gene id: 431947:PGN_RS08985
uniprot id: B2RM20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

431947:PGN RS06025
gene id: 431947:PGN_RS06025
uniprot id: B2RK82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

431947:PGN RS03130
gene id: 431947:PGN_RS03130
uniprot id: B2RII2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

431947:PGN RS05550
gene id: 431947:PGN_RS05550
uniprot id: B2RJY1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS00095
gene id: 431947:PGN_RS00095
uniprot id: B2RGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

431947:PGN RS05250
gene id: 431947:PGN_RS05250
uniprot id: B2RJS0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

431947:PGN RS03345
gene id: 431947:PGN_RS03345
uniprot id: B2RIM5
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Belongs to the peptidase C25 family.

431947:PGN RS03315
gene id: 431947:PGN_RS03315
uniprot id: B2RIL8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

431947:PGN RS02160
gene id: 431947:PGN_RS02160
uniprot id: B2RHX4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

431947:PGN RS07005
gene id: 431947:PGN_RS07005
uniprot id: B2RKU2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

431947:PGN RS08300
gene id: 431947:PGN_RS08300
uniprot id: B2RLM1
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS03530
gene id: 431947:PGN_RS03530
uniprot id: B2RIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

431947:PGN RS08865
gene id: 431947:PGN_RS08865
uniprot id: B2RLZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

431947:PGN RS00980
gene id: 431947:PGN_RS00980
uniprot id: B2RH83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS00180
gene id: 431947:PGN_RS00180
uniprot id: B2RGR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS02375
gene id: 431947:PGN_RS02375
uniprot id: B2RI22
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

431947:PGN RS05650
gene id: 431947:PGN_RS05650
uniprot id: B2RJ08
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS00485
gene id: 431947:PGN_RS00485
uniprot id: B2RGX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS07100
gene id: 431947:PGN_RS07100
uniprot id: B2RKW3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS07500
gene id: 431947:PGN_RS07500
uniprot id: B2RL49
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

431947:PGN RS05785
gene id: 431947:PGN_RS05785
uniprot id: B2RK27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

431947:PGN RS01280
gene id: 431947:PGN_RS01280
uniprot id: B2RHD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS05790
gene id: 431947:PGN_RS05790
uniprot id: B2RK28
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

431947:PGN RS01345
gene id: 431947:PGN_RS01345
uniprot id: B2RHF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

431947:PGN RS03815
gene id: 431947:PGN_RS03815
uniprot id: B2RIX4
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

431947:PGN RS01275
gene id: 431947:PGN_RS01275
uniprot id: B2RHD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

431947:PGN RS05360
gene id: 431947:PGN_RS05360
uniprot id: B2RJU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.

431947:PGN RS09205
gene id: 431947:PGN_RS09205
uniprot id: B2RM67
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

431947:PGN RS05730
gene id: 431947:PGN_RS05730
uniprot id: B2RK18
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

431947:PGN RS01585
gene id: 431947:PGN_RS01585
uniprot id: B2RHK4
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

431947:PGN RS00200
gene id: 431947:PGN_RS00200
uniprot id: B2RGR7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

431947:PGN RS07240
gene id: 431947:PGN_RS07240
uniprot id: B2RKZ2
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS05595
gene id: 431947:PGN_RS05595
uniprot id: B2RJZ0
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

431947:PGN RS03520
gene id: 431947:PGN_RS03520
uniprot id: B2RIR3
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

431947:PGN RS08680
gene id: 431947:PGN_RS08680
uniprot id: B2RLV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

431947:PGN RS04675
gene id: 431947:PGN_RS04675
uniprot id: B2RJE9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

431947:PGN RS05620
gene id: 431947:PGN_RS05620
uniprot id: B2RJZ5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

431947:PGN RS02555
gene id: 431947:PGN_RS02555
uniprot id: B2RI59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

431947:PGN RS00020
gene id: 431947:PGN_RS00020
uniprot id: B2RGM8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-55 and Arg-58) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

431947:PGN RS05890
gene id: 431947:PGN_RS05890
uniprot id: B2RK49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

431947:PGN RS06280
gene id: 431947:PGN_RS06280
uniprot id: B2RKD8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

431947:PGN RS00625
gene id: 431947:PGN_RS00625
uniprot id: B2RH08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

431947:PGN RS00935
gene id: 431947:PGN_RS00935
uniprot id: B2RH74
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS09895
gene id: 431947:PGN_RS09895
uniprot id: B2RMK6
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS09615
gene id: 431947:PGN_RS09615
uniprot id: B2RMF4
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

431947:PGN RS01665
gene id: 431947:PGN_RS01665
uniprot id: B2RHM2
names: Similarity
messages: Belongs to the universal stress protein A family.

431947:PGN RS05175
gene id: 431947:PGN_RS05175
uniprot id: B2RJQ3
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

431947:PGN RS03715
gene id: 431947:PGN_RS03715
uniprot id: B2RIV3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

431947:PGN RS01390
gene id: 431947:PGN_RS01390
uniprot id: B2RHG4
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.
messages: Cell outer membrane
messages: Component of the fimbrium tip. Minor fimbriae are composed of a structural subunit, most often Mfa1, and the accessory subunits Mfa3, Mfa4 and Mfa5 (PubMed:19589838, PubMed:24118823, PubMed:26001707, PubMed:26437277, PubMed:26972441). Mfa4 is required for Mfa3 and Mfa5 insertion into the fimbrium (PubMed:26437277). Fimbrium assembly occurs by linear, head-to-tail oligomerization of fimbrial subunits. This is mediated via insertion of a C-terminal beta-strand from one subunit into a groove in the N-terminal domain of the following subunit (PubMed:26972441).
messages: Fimbrium
messages: No effect on autoaggregation.
messages: The name (minor fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
messages: Tip subunit of the minor fimbriae. These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:19589838, PubMed:26001707). They play an important role in invasion of periodontal tissues and are recognized as major virulence factors (Probable).

431947:PGN RS09790
gene id: 431947:PGN_RS09790
uniprot id: B2RMI7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

431947:PGN RS07395
gene id: 431947:PGN_RS07395
uniprot id: B2RL25
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

431947:PGN RS01335
gene id: 431947:PGN_RS01335
uniprot id: B2RHF1
names: Similarity
messages: Belongs to the HSP15 family.

431947:PGN RS09480
gene id: 431947:PGN_RS09480
uniprot id: B2RMC6
names: Similarity
messages: Belongs to the RecJ family.

431947:PGN RS01855
gene id: 431947:PGN_RS01855
uniprot id: B2RHR4
names: Similarity
messages: Belongs to the CvfB family.

431947:PGN RS03955
gene id: 431947:PGN_RS03955
uniprot id: B2RJ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

431947:PGN RS08095
gene id: 431947:PGN_RS08095
uniprot id: B2RLH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

431947:PGN RS04775
gene id: 431947:PGN_RS04775
uniprot id: B2RJH1
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

431947:PGN RS05000
gene id: 431947:PGN_RS05000
uniprot id: B2RJL7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS06900
gene id: 431947:PGN_RS06900
uniprot id: B2RKR8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

431947:PGN RS01480
gene id: 431947:PGN_RS01480
uniprot id: B2RHI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

431947:PGN RS03780
gene id: 431947:PGN_RS03780
uniprot id: B2RIW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

431947:PGN RS09225
gene id: 431947:PGN_RS09225
uniprot id: B2RM71
names: Similarity
messages: Belongs to the DapB family.

431947:PGN RS08780
gene id: 431947:PGN_RS08780
uniprot id: B2RLX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

431947:PGN RS09660
gene id: 431947:PGN_RS09660
uniprot id: B2RMG4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

431947:PGN RS01075
gene id: 431947:PGN_RS01075
uniprot id: B2RH98
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

431947:PGN RS09495
gene id: 431947:PGN_RS09495
uniprot id: B2RMC9
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

431947:PGN RS04610
gene id: 431947:PGN_RS04610
uniprot id: B2RJD8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

431947:PGN RS02985
gene id: 431947:PGN_RS02985
uniprot id: B2RIF0
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS07385
gene id: 431947:PGN_RS07385
uniprot id: B2RL23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

431947:PGN RS06740
gene id: 431947:PGN_RS06740
uniprot id: B2RKN5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS08145
gene id: 431947:PGN_RS08145
uniprot id: B2RLI7
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: No longer responds to changes in hemin, decreased removal of 1-phosphate from lipid A species. Accumulates bi-phosphorylated pentaacyl and tetraacyl 1-phosphate lipid A species. Lipopolysaccharide (LPS) from this strain is a mild inducer of the human innate immune response via Toll-like receptor 4 (TLR4) in cultured HEK293 cells; double lpxE-lpxF mutants are more potent than either single mutant. No change in resistance to the cationic antimicrobial peptide (CAMP) polymyxin B. Double lpxE-lpxF mutants accumulate multiple mono- and bi-phosphorylated lipid A species (PubMed:19552698). Unable to colonize rabbit periodontium, a model for periodontal disease (PubMed:24478080).
messages: Periplasm
messages: Removes the 1-phosphate group from lipid A species. Absence of phosphate groups in lipid A renders the bacteria resistant to host-derived cationic antimicrobial peptides (CAMP) and allowing it to camouflage itself from the host innate immune response.
messages: When grown in low hemin conditions the major lipid A species are non-phosphorylated tetraacyl and 4'-phosphate pentaacyl lipid A, while under high hemin conditions the major lipid A species are non-phosphorylated tetraacyl and 1-phosphate tetraacyl lipid A (hemin is protoporphyrin IX containing Fe(3+) with a chloride ligand (CHEBI:50385) involved in the change from healthy to diseased gums).

431947:PGN RS05850
gene id: 431947:PGN_RS05850
uniprot id: B2RGQ1
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS00955
gene id: 431947:PGN_RS00955
uniprot id: B2RH78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

431947:PGN RS03860
gene id: 431947:PGN_RS03860
uniprot id: B2RIY2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

431947:PGN RS06405
gene id: 431947:PGN_RS06405
uniprot id: B2RKG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

431947:PGN RS00630
gene id: 431947:PGN_RS00630
uniprot id: B2RH09
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS03980
gene id: 431947:PGN_RS03980
uniprot id: B2RJ08
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS01340
gene id: 431947:PGN_RS01340
uniprot id: B2RHF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

431947:PGN RS00655
gene id: 431947:PGN_RS00655
uniprot id: B2RH13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

431947:PGN RS01685
gene id: 431947:PGN_RS01685
uniprot id: B2RHM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

431947:PGN RS00490
gene id: 431947:PGN_RS00490
uniprot id: B2RGX8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS07815
gene id: 431947:PGN_RS07815
uniprot id: B2RLB7
names: Similarity
messages: Belongs to the peptidase C25 family.

431947:PGN RS09810
gene id: 431947:PGN_RS09810
uniprot id: B2RMJ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

431947:PGN RS03595
gene id: 431947:PGN_RS03595
uniprot id: B2RIS8
names: Similarity
messages: Belongs to the peptidase C40 family.

431947:PGN RS08115
gene id: 431947:PGN_RS08115
uniprot id: B2RLI0
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS08215
gene id: 431947:PGN_RS08215
uniprot id: B2RLK2
names: Activity Regulation
names: Function
names: PTM
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
messages: Activated by the thiol-reducing agents cysteine, 2-mercaptoethanol and dithiothreitol. Inhibited by idoacetamide, idoacetic acid, leupeptin, tosyl-L-lysine and tosyl-L-phenylalanine. Not inhibited by elastatinal, chymostatin, cystatins, alpha1-antichymotrypsin or the serine protease inhibitors phenylmethylsulfonyl fluoride and diisopropylfluorophosphate. Not inhibited by metal ion chelators. Inhibited by the heavy metal ions Fe(3+), Zn(2+), Cu(2+) and Mn(2+).
messages: Belongs to the peptidase C25 family.
messages: Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria.
messages: Proteolytically cleaved into a catalytic subunit and three adhesins. Arg-gingipain is involved in this post-translational processing (By similarity).
messages: Secreted
messages: Several forms of kgp with differences at the C-terminus exist in different P.gingivalis strains.

431947:PGN RS08275
gene id: 431947:PGN_RS08275
uniprot id: B2RLL7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

431947:PGN RS03665
gene id: 431947:PGN_RS03665
uniprot id: B2RIU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

431947:PGN RS03415
gene id: 431947:PGN_RS03415
uniprot id: B2RIP0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

431947:PGN RS08135
gene id: 431947:PGN_RS08135
uniprot id: B2RLI5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

431947:PGN RS06745
gene id: 431947:PGN_RS06745
uniprot id: B2RKN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

431947:PGN RS09885
gene id: 431947:PGN_RS09885
uniprot id: B2RMK4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

431947:PGN RS04515
gene id: 431947:PGN_RS04515
uniprot id: B2RJC0
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS08970
gene id: 431947:PGN_RS08970
uniprot id: B2RM16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

431947:PGN RS01510
gene id: 431947:PGN_RS01510
uniprot id: B2RHI9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

431947:PGN RS02415
gene id: 431947:PGN_RS02415
uniprot id: B2RI32
names: Similarity
messages: Belongs to the peptidase C1 family.

431947:PGN RS06275
gene id: 431947:PGN_RS06275
uniprot id: B2RKD7
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS03835
gene id: 431947:PGN_RS03835
uniprot id: B2RIX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

431947:PGN RS00950
gene id: 431947:PGN_RS00950
uniprot id: B2RH77
names: Similarity
messages: Belongs to the SufE family.

431947:PGN RS08030
gene id: 431947:PGN_RS08030
uniprot id: B2RLG3
names: Similarity
messages: Belongs to the transketolase family.

431947:PGN RS09795
gene id: 431947:PGN_RS09795
uniprot id: B2RMI8
names: Similarity
messages: Belongs to the peptidase C25 family.

431947:PGN RS03265
gene id: 431947:PGN_RS03265
uniprot id: B2RIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

431947:PGN RS00850
gene id: 431947:PGN_RS00850
uniprot id: B2RH58
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FimD family.
messages: Cell outer membrane
messages: Fimbriae are composed of a major, structural subunit and the minor components FimC, FimD and FimE (PubMed:17526848, PubMed:19506009). Identified in a complex composed of FimC, FimD and FimE (in vitro) (PubMed:19506009). The complex interacts with host extracellular matrix proteins, including fibronectin and type I collagen (PubMed:17526848, PubMed:19506009). Interacts with host CXCR4 (PubMed:19506009).
messages: Fimbrium
messages: Probably a component of the fimbrium tip (PubMed:17526848, PubMed:19506009). These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:17526848). They play an important role in invasion of periodontal tissues and are major virulence factors. FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response (PubMed:17675496, PubMed:19506009).
messages: The name (major fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
messages: Triple mutants lacking FimC, FimD and FimE show strongly decreased interaction with host CXCR4 and impaired down-regulation of the TLR2-mediated innate immune response, resulting in strongly reduced survival of the bacteria.

431947:PGN RS08760
gene id: 431947:PGN_RS08760
uniprot id: B2RLX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

431947:PGN RS06045
gene id: 431947:PGN_RS06045
uniprot id: B2RK86
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

431947:PGN RS07870
gene id: 431947:PGN_RS07870
uniprot id: B2RLC7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

431947:PGN RS06225
gene id: 431947:PGN_RS06225
uniprot id: B2RKC6
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS01815
gene id: 431947:PGN_RS01815
uniprot id: B2RHQ6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

431947:PGN RS08320
gene id: 431947:PGN_RS08320
uniprot id: B2RLM5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

431947:PGN RS01700
gene id: 431947:PGN_RS01700
uniprot id: B2RHN0
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS00190
gene id: 431947:PGN_RS00190
uniprot id: B2RGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

431947:PGN RS02475
gene id: 431947:PGN_RS02475
uniprot id: B2RI44
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

431947:PGN RS05635
gene id: 431947:PGN_RS05635
uniprot id: B2RJZ8
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

431947:PGN RS00705
gene id: 431947:PGN_RS00705
uniprot id: B2RH24
names: Similarity
messages: Belongs to the DEAD box helicase family.

431947:PGN RS04785
gene id: 431947:PGN_RS04785
uniprot id: B2RJH3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

431947:PGN RS05265
gene id: 431947:PGN_RS05265
uniprot id: B2RJS3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

431947:PGN RS03150
gene id: 431947:PGN_RS03150
uniprot id: B2RII6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

431947:PGN RS08790
gene id: 431947:PGN_RS08790
uniprot id: B2RLX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

431947:PGN RS04365
gene id: 431947:PGN_RS04365
uniprot id: B2RJ90
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

431947:PGN RS02620
gene id: 431947:PGN_RS02620
uniprot id: B2RI74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

431947:PGN RS02995
gene id: 431947:PGN_RS02995
uniprot id: B2RIF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

431947:PGN RS01270
gene id: 431947:PGN_RS01270
uniprot id: B2RHD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

431947:PGN RS05400
gene id: 431947:PGN_RS05400
uniprot id: B2RJV0
names: Similarity
messages: Belongs to the peptidase S24 family.

431947:PGN RS00875
gene id: 431947:PGN_RS00875
uniprot id: B2RH63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

431947:PGN RS06825
gene id: 431947:PGN_RS06825
uniprot id: B2RKQ6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

431947:PGN RS03425
gene id: 431947:PGN_RS03425
uniprot id: B2RIP2
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS09235
gene id: 431947:PGN_RS09235
uniprot id: B2RM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

431947:PGN RS07950
gene id: 431947:PGN_RS07950
uniprot id: B2RLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

431947:PGN RS02670
gene id: 431947:PGN_RS02670
uniprot id: B2RI88
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

431947:PGN RS07730
gene id: 431947:PGN_RS07730
uniprot id: B2RLA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

431947:PGN RS04695
gene id: 431947:PGN_RS04695
uniprot id: B2RJF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

431947:PGN RS02935
gene id: 431947:PGN_RS02935
uniprot id: B2RIE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

431947:PGN RS03885
gene id: 431947:PGN_RS03885
uniprot id: B2RIY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

431947:PGN RS03360
gene id: 431947:PGN_RS03360
uniprot id: B2RIM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

431947:PGN RS05070
gene id: 431947:PGN_RS05070
uniprot id: B2RJN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

431947:PGN RS01835
gene id: 431947:PGN_RS01835
uniprot id: B2RHR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

431947:PGN RS02980
gene id: 431947:PGN_RS02980
uniprot id: B2RIE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

431947:PGN RS01425
gene id: 431947:PGN_RS01425
uniprot id: B2RHH2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

431947:PGN RS05285
gene id: 431947:PGN_RS05285
uniprot id: B2RJS8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

431947:PGN RS02975
gene id: 431947:PGN_RS02975
uniprot id: B2RIE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

431947:PGN RS08540
gene id: 431947:PGN_RS08540
uniprot id: B2RLS5
names: Similarity
messages: Belongs to the UPF0102 family.

431947:PGN RS03940
gene id: 431947:PGN_RS03940
uniprot id: B2RJ00
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

431947:PGN RS08160
gene id: 431947:PGN_RS08160
uniprot id: B2RLJ0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

431947:PGN RS03065
gene id: 431947:PGN_RS03065
uniprot id: B2RIG6
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS06730
gene id: 431947:PGN_RS06730
uniprot id: B2RKN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane
messages: Membrane

431947:PGN RS00385
gene id: 431947:PGN_RS00385
uniprot id: B2RGV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

431947:PGN RS01245
gene id: 431947:PGN_RS01245
uniprot id: B2RHD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

431947:PGN RS06555
gene id: 431947:PGN_RS06555
uniprot id: B2RKJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

431947:PGN RS00700
gene id: 431947:PGN_RS00700
uniprot id: B2RH23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

431947:PGN RS00160
gene id: 431947:PGN_RS00160
uniprot id: B2RGQ7
names: Similarity
messages: Belongs to the thioredoxin family.

431947:PGN RS08960
gene id: 431947:PGN_RS08960
uniprot id: B2RM14
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

431947:PGN RS03570
gene id: 431947:PGN_RS03570
uniprot id: B2RIS3
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS08830
gene id: 431947:PGN_RS08830
uniprot id: B2RLY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

431947:PGN RS01760
gene id: 431947:PGN_RS01760
uniprot id: B2RHP4
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS04885
gene id: 431947:PGN_RS04885
uniprot id: B2RJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

431947:PGN RS06975
gene id: 431947:PGN_RS06975
uniprot id: B2RKT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

431947:PGN RS03890
gene id: 431947:PGN_RS03890
uniprot id: B2RIY8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

431947:PGN RS02450
gene id: 431947:PGN_RS02450
uniprot id: B2RI39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

431947:PGN RS06635
gene id: 431947:PGN_RS06635
uniprot id: B2RKL7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

431947:PGN RS08870
gene id: 431947:PGN_RS08870
uniprot id: B2RLZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

431947:PGN RS04205
gene id: 431947:PGN_RS04205
uniprot id: B2RJ54
names: Similarity
messages: Belongs to the beta-eliminating lyase family.

431947:PGN RS07575
gene id: 431947:PGN_RS07575
uniprot id: B2RL63
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

431947:PGN RS08360
gene id: 431947:PGN_RS08360
uniprot id: B2RLN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

431947:PGN RS09315
gene id: 431947:PGN_RS09315
uniprot id: B2RM92
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

431947:PGN RS00885
gene id: 431947:PGN_RS00885
uniprot id: B2RH65
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

431947:PGN RS09780
gene id: 431947:PGN_RS09780
uniprot id: B2RMI4
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

431947:PGN RS04600
gene id: 431947:PGN_RS04600
uniprot id: B2RJD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS01755
gene id: 431947:PGN_RS01755
uniprot id: B2RHP3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS02495
gene id: 431947:PGN_RS02495
uniprot id: B2RI47
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

431947:PGN RS03935
gene id: 431947:PGN_RS03935
uniprot id: B2RIZ8
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

431947:PGN RS04850
gene id: 431947:PGN_RS04850
uniprot id: B2RJI7
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

431947:PGN RS02915
gene id: 431947:PGN_RS02915
uniprot id: B2RID5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

431947:PGN RS05315
gene id: 431947:PGN_RS05315
uniprot id: B2RJT4
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS07565
gene id: 431947:PGN_RS07565
uniprot id: B2RL61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

431947:PGN RS01350
gene id: 431947:PGN_RS01350
uniprot id: B2RHF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

431947:PGN RS03500
gene id: 431947:PGN_RS03500
uniprot id: B2RIQ9
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

431947:PGN RS00540
gene id: 431947:PGN_RS00540
uniprot id: B2RGY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

431947:PGN RS00835
gene id: 431947:PGN_RS00835
uniprot id: B2RH54
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.
messages: Cell outer membrane
messages: FimA-deficient cells lack major fimbriae, resulting in strongly decreased adherence to host cells (PubMed:12593606, PubMed:17675496). Double mutants lacking both FimA and Mfa1 lack major and minor fimbriae; they fail to adhere to host cells.
messages: Fimbriae are composed of a major, structural subunit (FimA) and the minor components FimC, FimD and FimE (PubMed:17675496, PubMed:17526848). Head-to-tail oligomerization of FimA molecules mediates assembly of the fimbrium stalk, while the minor components probably form the fimbrium tip. Linear, head-to-tail oligomerization of FimA is mediated by a conformation change, facilitating the insertion of a C-terminal beta-strand into a groove in the N-terminal domain of the following subunit (By similarity). The anchoring subunit FimB limits fimbrium length and is important for solid fimbrium attachment to the outer membrane. In its absence, the major fimbriae become very long and are easily detached from the membrane (PubMed:27062925).
messages: Fimbrium
messages: In some prokaryotes, a valine codon can be used as start of translation. The Val-37 codon had been proposed to serve as start of translation for FimA, but mutagenesis of Val-37 to Ala has no effect on FimA biosynthesis.
messages: Structural subunit of the major fimbriae. These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:9786913, PubMed:12593606, PubMed:15165251, PubMed:17675496, PubMed:17526848, PubMed:20530728, PubMed:27062925). They play an important role in the invasion of periodontal tissues (PubMed:12593606). Fimbriae and their constituents are major virulence factors. FimA proteins from different strains have highly divergent sequences, and this has been used for classification (PubMed:23809984). The sequence-based classification correlates with pathogenicity (PubMed:17675496).
messages: Synthesized as palmitoylated precursor (PubMed:15165251). Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide (PubMed:8778568, PubMed:9786913, PubMed:15165251).
messages: The name (major fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.

431947:PGN RS08675
gene id: 431947:PGN_RS08675
uniprot id: B2RLV5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

431947:PGN RS09180
gene id: 431947:PGN_RS09180
uniprot id: B2RM61
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

431947:PGN RS01710
gene id: 431947:PGN_RS01710
uniprot id: B2RHN2
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

431947:PGN RS09220
gene id: 431947:PGN_RS09220
uniprot id: B2RM70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

431947:PGN RS02315
gene id: 431947:PGN_RS02315
uniprot id: B2RI08
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

431947:PGN RS09760
gene id: 431947:PGN_RS09760
uniprot id: B2RMI0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

431947:PGN RS00170
gene id: 431947:PGN_RS00170
uniprot id: B2RGQ9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

431947:PGN RS09545
gene id: 431947:PGN_RS09545
uniprot id: B2RME0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS02700
gene id: 431947:PGN_RS02700
uniprot id: B2RI94
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

431947:PGN RS03320
gene id: 431947:PGN_RS03320
uniprot id: B2RIL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

431947:PGN RS06720
gene id: 431947:PGN_RS06720
uniprot id: B2RIE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

431947:PGN RS00685
gene id: 431947:PGN_RS00685
uniprot id: B2RH19
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS10835
gene id: 431947:PGN_RS10835
uniprot id: B2RLW9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

431947:PGN RS05905
gene id: 431947:PGN_RS05905
uniprot id: B2RK53
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

431947:PGN RS00535
gene id: 431947:PGN_RS00535
uniprot id: B2RGY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

431947:PGN RS04680
gene id: 431947:PGN_RS04680
uniprot id: B2RJF0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

431947:PGN RS08755
gene id: 431947:PGN_RS08755
uniprot id: B2RLX1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

431947:PGN RS03460
gene id: 431947:PGN_RS03460
uniprot id: B2RIP9
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

431947:PGN RS04905
gene id: 431947:PGN_RS04905
uniprot id: B2RJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

431947:PGN RS08305
gene id: 431947:PGN_RS08305
uniprot id: B2RLM2
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS04995
gene id: 431947:PGN_RS04995
uniprot id: B2RJL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

431947:PGN RS01130
gene id: 431947:PGN_RS01130
uniprot id: B2RHA9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

431947:PGN RS07170
gene id: 431947:PGN_RS07170
uniprot id: B2RKX8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

431947:PGN RS06255
gene id: 431947:PGN_RS06255
uniprot id: B2RKD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

431947:PGN RS03730
gene id: 431947:PGN_RS03730
uniprot id: B2RIV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

431947:PGN RS05750
gene id: 431947:PGN_RS05750
uniprot id: B2RK20
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

431947:PGN RS05540
gene id: 431947:PGN_RS05540
uniprot id: B2RJX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS01310
gene id: 431947:PGN_RS01310
uniprot id: B2RHE5
names: Similarity
messages: Belongs to the peptidase M13 family.

431947:PGN RS05865
gene id: 431947:PGN_RS05865
uniprot id: B2RK44
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

431947:PGN RS07685
gene id: 431947:PGN_RS07685
uniprot id: B2RL88
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

431947:PGN RS03580
gene id: 431947:PGN_RS03580
uniprot id: B2RIS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

431947:PGN RS04295
gene id: 431947:PGN_RS04295
uniprot id: B2RJ75
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

431947:PGN RS02565
gene id: 431947:PGN_RS02565
uniprot id: B2RI62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

431947:PGN RS06060
gene id: 431947:PGN_RS06060
uniprot id: B2RK91
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

431947:PGN RS09485
gene id: 431947:PGN_RS09485
uniprot id: B2RMC7
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS01575
gene id: 431947:PGN_RS01575
uniprot id: B2RHK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

431947:PGN RS08155
gene id: 431947:PGN_RS08155
uniprot id: B2RLI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

431947:PGN RS08685
gene id: 431947:PGN_RS08685
uniprot id: B2RLV7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS04720
gene id: 431947:PGN_RS04720
uniprot id: B2RJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

431947:PGN RS03505
gene id: 431947:PGN_RS03505
uniprot id: B2RIR0
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

431947:PGN RS08105
gene id: 431947:PGN_RS08105
uniprot id: B2RLH8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

431947:PGN RS07800
gene id: 431947:PGN_RS07800
uniprot id: B2RLB4
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS01325
gene id: 431947:PGN_RS01325
uniprot id: B2RHE9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

431947:PGN RS00155
gene id: 431947:PGN_RS00155
uniprot id: B2RGQ5
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

431947:PGN RS09825
gene id: 431947:PGN_RS09825
uniprot id: B2RMJ4
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

431947:PGN RS01045
gene id: 431947:PGN_RS01045
uniprot id: B2RH92
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS09500
gene id: 431947:PGN_RS09500
uniprot id: B2RMD0
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

431947:PGN RS00750
gene id: 431947:PGN_RS00750
uniprot id: B2RH34
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

431947:PGN RS04095
gene id: 431947:PGN_RS04095
uniprot id: B2RJ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

431947:PGN RS05275
gene id: 431947:PGN_RS05275
uniprot id: B2RJS7
names: Similarity
messages: Belongs to the peptidase C69 family.

431947:PGN RS01895
gene id: 431947:PGN_RS01895
uniprot id: B2RHS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

431947:PGN RS08365
gene id: 431947:PGN_RS08365
uniprot id: B2RLN4
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

431947:PGN RS03030
gene id: 431947:PGN_RS03030
uniprot id: B2RIF9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

431947:PGN RS08800
gene id: 431947:PGN_RS08800
uniprot id: B2RLY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

431947:PGN RS09555
gene id: 431947:PGN_RS09555
uniprot id: B2RME2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

431947:PGN RS00115
gene id: 431947:PGN_RS00115
uniprot id: B2RGP8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

431947:PGN RS08950
gene id: 431947:PGN_RS08950
uniprot id: B2RM12
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

431947:PGN RS01695
gene id: 431947:PGN_RS01695
uniprot id: B2RHM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

431947:PGN RS08880
gene id: 431947:PGN_RS08880
uniprot id: B2RLZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

431947:PGN RS02885
gene id: 431947:PGN_RS02885
uniprot id: B2RIC9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS01400
gene id: 431947:PGN_RS01400
uniprot id: B2RHG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

431947:PGN RS09130
gene id: 431947:PGN_RS09130
uniprot id: B2RKQ7
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS05430
gene id: 431947:PGN_RS05430
uniprot id: B2RJV6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS08725
gene id: 431947:PGN_RS08725
uniprot id: B2RLW4
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

431947:PGN RS07345
gene id: 431947:PGN_RS07345
uniprot id: B2RL13
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

431947:PGN RS07495
gene id: 431947:PGN_RS07495
uniprot id: B2RL48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

431947:PGN RS02465
gene id: 431947:PGN_RS02465
uniprot id: B2RI42
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

431947:PGN RS02330
gene id: 431947:PGN_RS02330
uniprot id: B2RI11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

431947:PGN RS04840
gene id: 431947:PGN_RS04840
uniprot id: B2RJI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

431947:PGN RS05510
gene id: 431947:PGN_RS05510
uniprot id: B2RJX3
names: Function
names: Similarity
messages: Belongs to the peptidase S9B family.
messages: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position (By similarity).

431947:PGN RS07235
gene id: 431947:PGN_RS07235
uniprot id: B2RKZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

431947:PGN RS04340
gene id: 431947:PGN_RS04340
uniprot id: B2RJ85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase H family.
messages: Binds 2 metal ions per subunit. Manganese or magnesium.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

431947:PGN RS09260
gene id: 431947:PGN_RS09260
uniprot id: B2RM81
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS08590
gene id: 431947:PGN_RS08590
uniprot id: B2RLT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

431947:PGN RS03055
gene id: 431947:PGN_RS03055
uniprot id: B2RIG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

431947:PGN RS02600
gene id: 431947:PGN_RS02600
uniprot id: B2RI70
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

431947:PGN RS08585
gene id: 431947:PGN_RS08585
uniprot id: B2RLT6
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

431947:PGN RS08525
gene id: 431947:PGN_RS08525
uniprot id: B2RLS1
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS01555
gene id: 431947:PGN_RS01555
uniprot id: B2RHJ8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS01460
gene id: 431947:PGN_RS01460
uniprot id: B2RHH7
names: Similarity
messages: Belongs to the peptidase M16 family.

431947:PGN RS07895
gene id: 431947:PGN_RS07895
uniprot id: B2RLD2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

431947:PGN RS01475
gene id: 431947:PGN_RS01475
uniprot id: B2RHI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

431947:PGN RS02795
gene id: 431947:PGN_RS02795
uniprot id: B2RIB1
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS02920
gene id: 431947:PGN_RS02920
uniprot id: B2RID6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS04650
gene id: 431947:PGN_RS04650
uniprot id: B2RJE5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS07115
gene id: 431947:PGN_RS07115
uniprot id: B2RKW6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

431947:PGN RS01830
gene id: 431947:PGN_RS01830
uniprot id: B2RHQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

431947:PGN RS09675
gene id: 431947:PGN_RS09675
uniprot id: B2RMG8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

431947:PGN RS05525
gene id: 431947:PGN_RS05525
uniprot id: B2RJX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

431947:PGN RS08815
gene id: 431947:PGN_RS08815
uniprot id: B2RLY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

431947:PGN RS02705
gene id: 431947:PGN_RS02705
uniprot id: B2RI95
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

431947:PGN RS09075
gene id: 431947:PGN_RS09075
uniprot id: B2RJC6
names: Similarity
messages: Belongs to the peptidase S41A family.

431947:PGN RS06570
gene id: 431947:PGN_RS06570
uniprot id: B2RKK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

431947:PGN RS01505
gene id: 431947:PGN_RS01505
uniprot id: B2RHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

431947:PGN RS06205
gene id: 431947:PGN_RS06205
uniprot id: B2RKC1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS08435
gene id: 431947:PGN_RS08435
uniprot id: B2RLQ0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

431947:PGN RS07825
gene id: 431947:PGN_RS07825
uniprot id: B2RHJ8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS08535
gene id: 431947:PGN_RS08535
uniprot id: B2RLS4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS01395
gene id: 431947:PGN_RS01395
uniprot id: B2RHG5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the minor fimbriae. These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:26001707). They play an important role in invasion of periodontal tissues and are recognized as major virulence factors. Fimbrium subunits from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).
messages: Fimbrium
messages: Minor fimbriae are composed of a structural subunit, most often Mfa1, and the accessory subunits Mfa3, Mfa4 and Mfa5 (PubMed:19589838, PubMed:24118823, PubMed:26001707, PubMed:26437277). Fimbrium assembly occurs by linear, head-to-tail oligomerization of fimbrial subunits. This is mediated via insertion of a C-terminal beta-strand from one subunit into a groove in the N-terminal domain of the following subunit (Probable).
messages: The name (minor fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.

431947:PGN RS02590
gene id: 431947:PGN_RS02590
uniprot id: B2RI68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

431947:PGN RS05870
gene id: 431947:PGN_RS05870
uniprot id: B2RK45
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

431947:PGN RS03410
gene id: 431947:PGN_RS03410
uniprot id: B2RIN9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

431947:PGN RS05355
gene id: 431947:PGN_RS05355
uniprot id: B2RH84
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS04125
gene id: 431947:PGN_RS04125
uniprot id: B2RJ39
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

431947:PGN RS02460
gene id: 431947:PGN_RS02460
uniprot id: B2RI41
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

431947:PGN RS03190
gene id: 431947:PGN_RS03190
uniprot id: B2RIJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

431947:PGN RS08750
gene id: 431947:PGN_RS08750
uniprot id: B2RLX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

431947:PGN RS03075
gene id: 431947:PGN_RS03075
uniprot id: B2RIG8
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS03785
gene id: 431947:PGN_RS03785
uniprot id: B2RIW7
names: Similarity
messages: Belongs to the disproportionating enzyme family.
messages: Belongs to the peptidase C25 family.

431947:PGN RS00205
gene id: 431947:PGN_RS00205
uniprot id: B2RGR8
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

431947:PGN RS01745
gene id: 431947:PGN_RS01745
uniprot id: B2RHP1
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

431947:PGN RS05795
gene id: 431947:PGN_RS05795
uniprot id: B2RK29
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

431947:PGN RS04790
gene id: 431947:PGN_RS04790
uniprot id: B2RJH4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

431947:PGN RS08060
gene id: 431947:PGN_RS08060
uniprot id: B2RLG9
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

431947:PGN RS00910
gene id: 431947:PGN_RS00910
uniprot id: B2RH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

431947:PGN RS09190
gene id: 431947:PGN_RS09190
uniprot id: B2RM63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS03650
gene id: 431947:PGN_RS03650
uniprot id: B2RIU0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

431947:PGN RS00775
gene id: 431947:PGN_RS00775
uniprot id: B2RH41
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

431947:PGN RS02020
gene id: 431947:PGN_RS02020
uniprot id: B2RHU7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

431947:PGN RS04115
gene id: 431947:PGN_RS04115
uniprot id: B2RJ37
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

431947:PGN RS00965
gene id: 431947:PGN_RS00965
uniprot id: B2RH80
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

431947:PGN RS09215
gene id: 431947:PGN_RS09215
uniprot id: B2RM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

431947:PGN RS04275
gene id: 431947:PGN_RS04275
uniprot id: B2RJ69
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

431947:PGN RS01500
gene id: 431947:PGN_RS01500
uniprot id: B2RHI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

431947:PGN RS05780
gene id: 431947:PGN_RS05780
uniprot id: B2RK26
names: Similarity
messages: Belongs to the sigma-54 factor family.

431947:PGN RS06890
gene id: 431947:PGN_RS06890
uniprot id: B2RIC9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS09445
gene id: 431947:PGN_RS09445
uniprot id: B2RMB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

431947:PGN RS01070
gene id: 431947:PGN_RS01070
uniprot id: B2RH97
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS02130
gene id: 431947:PGN_RS02130
uniprot id: B2RHW8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

431947:PGN RS02345
gene id: 431947:PGN_RS02345
uniprot id: B2RI15
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

431947:PGN RS09560
gene id: 431947:PGN_RS09560
uniprot id: B2RME3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

431947:PGN RS02970
gene id: 431947:PGN_RS02970
uniprot id: B2RIE7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS04135
gene id: 431947:PGN_RS04135
uniprot id: B2RJ41
names: Similarity
messages: Belongs to the MreC family.

431947:PGN RS01715
gene id: 431947:PGN_RS01715
uniprot id: B2RHN3
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

431947:PGN RS04480
gene id: 431947:PGN_RS04480
uniprot id: B2RJB2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

431947:PGN RS05760
gene id: 431947:PGN_RS05760
uniprot id: B2RK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

431947:PGN RS06340
gene id: 431947:PGN_RS06340
uniprot id: B2RKF1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

431947:PGN RS06305
gene id: 431947:PGN_RS06305
uniprot id: B2RGQ1
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS05575
gene id: 431947:PGN_RS05575
uniprot id: B2RJY6
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

431947:PGN RS03250
gene id: 431947:PGN_RS03250
uniprot id: B2RIK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

431947:PGN RS07025
gene id: 431947:PGN_RS07025
uniprot id: B2RKU6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS02595
gene id: 431947:PGN_RS02595
uniprot id: B2RI69
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

431947:PGN RS05260
gene id: 431947:PGN_RS05260
uniprot id: B2RJS2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

431947:PGN RS07490
gene id: 431947:PGN_RS07490
uniprot id: B2RL47
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

431947:PGN RS03205
gene id: 431947:PGN_RS03205
uniprot id: B2RIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

431947:PGN RS08265
gene id: 431947:PGN_RS08265
uniprot id: B2RLL4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

431947:PGN RS03915
gene id: 431947:PGN_RS03915
uniprot id: B2RIZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

431947:PGN RS01690
gene id: 431947:PGN_RS01690
uniprot id: B2RHM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

431947:PGN RS04290
gene id: 431947:PGN_RS04290
uniprot id: B2RJ74
names: Similarity
messages: Belongs to the peptidase C10 family.

431947:PGN RS06915
gene id: 431947:PGN_RS06915
uniprot id: B2RKS1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

431947:PGN RS01785
gene id: 431947:PGN_RS01785
uniprot id: B2RHQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

431947:PGN RS00030
gene id: 431947:PGN_RS00030
uniprot id: B2RGN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

431947:PGN RS02550
gene id: 431947:PGN_RS02550
uniprot id: B2RI58
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

431947:PGN RS07875
gene id: 431947:PGN_RS07875
uniprot id: B2RLC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

431947:PGN RS01155
gene id: 431947:PGN_RS01155
uniprot id: B2RHB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

431947:PGN RS01705
gene id: 431947:PGN_RS01705
uniprot id: B2RHN1
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

431947:PGN RS00815
gene id: 431947:PGN_RS00815
uniprot id: B2RH49
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

431947:PGN RS01200
gene id: 431947:PGN_RS01200
uniprot id: B2RHC3
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS09135
gene id: 431947:PGN_RS09135
uniprot id: B2RM51
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

431947:PGN RS08775
gene id: 431947:PGN_RS08775
uniprot id: B2RLX5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

431947:PGN RS01440
gene id: 431947:PGN_RS01440
uniprot id: B2RHH5
names: Similarity
messages: Belongs to the Skp family.

431947:PGN RS09375
gene id: 431947:PGN_RS09375
uniprot id: B2RMA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

431947:PGN RS04855
gene id: 431947:PGN_RS04855
uniprot id: B2RJI8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

431947:PGN RS06625
gene id: 431947:PGN_RS06625
uniprot id: B2RKL4
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

431947:PGN RS09380
gene id: 431947:PGN_RS09380
uniprot id: B2RMA6
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS08600
gene id: 431947:PGN_RS08600
uniprot id: B2RLT9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

431947:PGN RS05860
gene id: 431947:PGN_RS05860
uniprot id: B2RK43
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

431947:PGN RS02350
gene id: 431947:PGN_RS02350
uniprot id: B2RI16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

431947:PGN RS01600
gene id: 431947:PGN_RS01600
uniprot id: B2RHK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

431947:PGN RS00995
gene id: 431947:PGN_RS00995
uniprot id: B2RH86
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS08735
gene id: 431947:PGN_RS08735
uniprot id: B2RLW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

431947:PGN RS05465
gene id: 431947:PGN_RS05465
uniprot id: B2RJW4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS09275
gene id: 431947:PGN_RS09275
uniprot id: B2RM84
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

431947:PGN RS00130
gene id: 431947:PGN_RS00130
uniprot id: B2RGQ0
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

431947:PGN RS07460
gene id: 431947:PGN_RS07460
uniprot id: B2RL41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

431947:PGN RS00555
gene id: 431947:PGN_RS00555
uniprot id: B2RGZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

431947:PGN RS04385
gene id: 431947:PGN_RS04385
uniprot id: B2RJ92
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS06035
gene id: 431947:PGN_RS06035
uniprot id: B2RK84
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

431947:PGN RS02765
gene id: 431947:PGN_RS02765
uniprot id: B2RIA6
names: Similarity
messages: Belongs to the type IA topoisomerase family.

431947:PGN RS01750
gene id: 431947:PGN_RS01750
uniprot id: B2RHP2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

431947:PGN RS03430
gene id: 431947:PGN_RS03430
uniprot id: B2RIP3
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS01675
gene id: 431947:PGN_RS01675
uniprot id: B2RHM4
names: Similarity
messages: Belongs to the SUI1 family.

431947:PGN RS05920
gene id: 431947:PGN_RS05920
uniprot id: B2RK56
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

431947:PGN RS07840
gene id: 431947:PGN_RS07840
uniprot id: B2RLC1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

431947:PGN RS08825
gene id: 431947:PGN_RS08825
uniprot id: B2RLY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

431947:PGN RS05530
gene id: 431947:PGN_RS05530
uniprot id: B2RJX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS06270
gene id: 431947:PGN_RS06270
uniprot id: B2RKD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

431947:PGN RS03390
gene id: 431947:PGN_RS03390
uniprot id: B2RIN4
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.

431947:PGN RS08025
gene id: 431947:PGN_RS08025
uniprot id: B2RLG2
names: Similarity
messages: Belongs to the LacAB/RpiB family.

431947:PGN RS02990
gene id: 431947:PGN_RS02990
uniprot id: B2RIF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

431947:PGN RS05505
gene id: 431947:PGN_RS05505
uniprot id: B2RJX2
names: Similarity
messages: Belongs to the GARS family.

431947:PGN RS07485
gene id: 431947:PGN_RS07485
uniprot id: B2RL46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

431947:PGN RS02605
gene id: 431947:PGN_RS02605
uniprot id: B2RI71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

431947:PGN RS07805
gene id: 431947:PGN_RS07805
uniprot id: B2RLB5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

431947:PGN RS00620
gene id: 431947:PGN_RS00620
uniprot id: B2RH07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS06660
gene id: 431947:PGN_RS06660
uniprot id: B2RIC9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS08805
gene id: 431947:PGN_RS08805
uniprot id: B2RLY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

431947:PGN RS07125
gene id: 431947:PGN_RS07125
uniprot id: B2RKW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

431947:PGN RS05445
gene id: 431947:PGN_RS05445
uniprot id: B2RJW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

431947:PGN RS08730
gene id: 431947:PGN_RS08730
uniprot id: B2RLW5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

431947:PGN RS07680
gene id: 431947:PGN_RS07680
uniprot id: B2RL87
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

431947:PGN RS05195
gene id: 431947:PGN_RS05195
uniprot id: B2RJQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

431947:PGN RS01140
gene id: 431947:PGN_RS01140
uniprot id: B2RHB1
names: Similarity
messages: Belongs to the IMPACT family.

431947:PGN RS02410
gene id: 431947:PGN_RS02410
uniprot id: B2RI31
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS08050
gene id: 431947:PGN_RS08050
uniprot id: B2RLG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

431947:PGN RS01385
gene id: 431947:PGN_RS01385
uniprot id: B2RHG3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacteroidetes fimbrillin superfamily. FimB/Mfa2 family.
messages: Cell outer membrane
messages: Component of the fimbrium tip (PubMed:24118823). Minor fimbriae are composed of a structural subunit, most often Mfa1, and the accessory subunits Mfa3, Mfa4 and Mfa5 (PubMed:19589838, PubMed:24118823, PubMed:26001707). Fimbrium assembly occurs by linear, head-to-tail oligomerization of fimbrial subunits. This is mediated via insertion of a C-terminal beta-strand from one subunit into a groove in the N-terminal domain of the following subunit (Probable). Mfa3 is required for Mfa4 and Mfa5 insertion into the fimbrium (PubMed:24118823).
messages: Fimbrium
messages: Mildly increased autoaggregation.
messages: The name (minor fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
messages: Tip subunit of the minor fimbriae. These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:24118823, PubMed:26001707). They play an important role in invasion of periodontal tissues and are recognized as major virulence factors. Fimbrium subunits from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).

431947:PGN RS06090
gene id: 431947:PGN_RS06090
uniprot id: B2RK97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

431947:PGN RS03175
gene id: 431947:PGN_RS03175
uniprot id: B2RIJ1
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homomer.

431947:PGN RS06100
gene id: 431947:PGN_RS06100
uniprot id: B2RGX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS03830
gene id: 431947:PGN_RS03830
uniprot id: B2RIX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

431947:PGN RS00905
gene id: 431947:PGN_RS00905
uniprot id: B2RH69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS05010
gene id: 431947:PGN_RS05010
uniprot id: B2RJL9
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Belongs to the peptidase C25 family.

431947:PGN RS08990
gene id: 431947:PGN_RS08990
uniprot id: B2RM21
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS04355
gene id: 431947:PGN_RS04355
uniprot id: B2RJ88
names: Similarity
messages: Belongs to the peptidase M24B family.

431947:PGN RS07480
gene id: 431947:PGN_RS07480
uniprot id: B2RL45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

431947:PGN RS05880
gene id: 431947:PGN_RS05880
uniprot id: B2RK47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

431947:PGN RS07580
gene id: 431947:PGN_RS07580
uniprot id: B2RL64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

431947:PGN RS06985
gene id: 431947:PGN_RS06985
uniprot id: B2RKT6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

431947:PGN RS08580
gene id: 431947:PGN_RS08580
uniprot id: B2RLT5
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

431947:PGN RS07595
gene id: 431947:PGN_RS07595
uniprot id: B2RL67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

431947:PGN RS09640
gene id: 431947:PGN_RS09640
uniprot id: B2RMG0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Constitutively expressed but is up-regulated by exposure to atomospheric oxygen in an OxyR-dependent manner.
messages: Cytoplasm
messages: Homododecamer.
messages: Responsible for protection of cells against peroxide, especially against hydrogen peroxide. Required for survival in host cells. Although it binds iron, it may not contribute to iron storage. The iron-loaded dps has DNA-binding activity.

431947:PGN RS07545
gene id: 431947:PGN_RS07545
uniprot id: B2RL55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

431947:PGN RS00550
gene id: 431947:PGN_RS00550
uniprot id: B2RGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

431947:PGN RS03960
gene id: 431947:PGN_RS03960
uniprot id: B2RJ04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.
messages: Homodimer.

431947:PGN RS07890
gene id: 431947:PGN_RS07890
uniprot id: B2RLD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

431947:PGN RS00940
gene id: 431947:PGN_RS00940
uniprot id: B2RH75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

431947:PGN RS03845
gene id: 431947:PGN_RS03845
uniprot id: B2RIY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

431947:PGN RS00970
gene id: 431947:PGN_RS00970
uniprot id: B2RH81
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

431947:PGN RS05715
gene id: 431947:PGN_RS05715
uniprot id: B2RIA1
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS04895
gene id: 431947:PGN_RS04895
uniprot id: B2RJJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

431947:PGN RS00560
gene id: 431947:PGN_RS00560
uniprot id: B2RGZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

431947:PGN RS00855
gene id: 431947:PGN_RS00855
uniprot id: B2RH59
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FimE family.
messages: Cell outer membrane
messages: Fimbriae are composed of a major, structural subunit and the minor components FimC, FimD and FimE (PubMed:17526848, PubMed:19506009). Identified in a complex composed of FimC, FimD and FimE (in vitro) (PubMed:19506009). Does not directly interact with host proteins, but only as a complex with FimC and FimD (PubMed:19506009).
messages: Fimbrium
messages: Probably a component of the fimbrium tip; required for incorporation of FimC and FimD into fimbriae (PubMed:17526848, PubMed:19506009). These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:17526848, PubMed:19506009). They play an important role in invasion of periodontal tissues and are major virulence factors (Probable). FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response (PubMed:19506009).
messages: The name (major fimbrium subunit) does not indicate the abundance of the protein, but is derived from the greater length of the major fimbriae. In strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, major fimbriae are 300 - 1600 nM in length and about 5 nm in diameter. In contrast, minor fimbriae are only about 80 - 120 nm long. This length difference is observed only in a small number of strains, including strain ATCC 33277 and strain ATCC BAA-1703 / FDC 381, and is due to a loss of function mutation in FimB, a protein that restricts fimbrial length in other strains.
messages: Triple mutants lacking FimC, FimD and FimE show strongly decreased interaction with host CXCR4 and impaired down-regulation of the TLR2-mediated innate immune response, resulting in strongly reduced survival of the bacteria.

431947:PGN RS08925
gene id: 431947:PGN_RS08925
uniprot id: B2RM06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

431947:PGN RS07225
gene id: 431947:PGN_RS07225
uniprot id: B2RKY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS06895
gene id: 431947:PGN_RS06895
uniprot id: B2RKR7
names: Similarity
messages: Belongs to the CarB family.

431947:PGN RS07505
gene id: 431947:PGN_RS07505
uniprot id: B2RL50
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

431947:PGN RS07900
gene id: 431947:PGN_RS07900
uniprot id: B2RLD3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

431947:PGN RS08505
gene id: 431947:PGN_RS08505
uniprot id: B2RLR6
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

431947:PGN RS05640
gene id: 431947:PGN_RS05640
uniprot id: B2RJZ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

431947:PGN RS04920
gene id: 431947:PGN_RS04920
uniprot id: B2RJK1
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

431947:PGN RS01515
gene id: 431947:PGN_RS01515
uniprot id: B2RHJ0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

431947:PGN RS09290
gene id: 431947:PGN_RS09290
uniprot id: B2RM87
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

431947:PGN RS08180
gene id: 431947:PGN_RS08180
uniprot id: B2RLJ5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

431947:PGN RS04175
gene id: 431947:PGN_RS04175
uniprot id: B2RJ49
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

431947:PGN RS06820
gene id: 431947:PGN_RS06820
uniprot id: B2RKQ5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

431947:PGN RS08555
gene id: 431947:PGN_RS08555
uniprot id: B2RLS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

431947:PGN RS04930
gene id: 431947:PGN_RS04930
uniprot id: B2RJK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

431947:PGN RS01320
gene id: 431947:PGN_RS01320
uniprot id: B2RHE8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

431947:PGN RS01870
gene id: 431947:PGN_RS01870
uniprot id: B2RHR7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

431947:PGN RS01610
gene id: 431947:PGN_RS01610
uniprot id: B2RHK9
names: Similarity
messages: Belongs to the peptidase C25 family.

431947:PGN RS03020
gene id: 431947:PGN_RS03020
uniprot id: B2RIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

431947:PGN RS08575
gene id: 431947:PGN_RS08575
uniprot id: B2RLT2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Fimbrium
messages: Membrane

431947:PGN RS04150
gene id: 431947:PGN_RS04150
uniprot id: B2RJ44
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS01300
gene id: 431947:PGN_RS01300
uniprot id: B2RHE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

431947:PGN RS00675
gene id: 431947:PGN_RS00675
uniprot id: B2RH17
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

431947:PGN RS01525
gene id: 431947:PGN_RS01525
uniprot id: B2RHJ2
names: Similarity
messages: Belongs to the CobH/CbiC family.

431947:PGN RS05855
gene id: 431947:PGN_RS05855
uniprot id: B2RK42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS04130
gene id: 431947:PGN_RS04130
uniprot id: B2RJ40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS03865
gene id: 431947:PGN_RS03865
uniprot id: B2RIY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

431947:PGN RS09250
gene id: 431947:PGN_RS09250
uniprot id: B2RM78
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

431947:PGN RS08655
gene id: 431947:PGN_RS08655
uniprot id: B2RLV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

431947:PGN RS00880
gene id: 431947:PGN_RS00880
uniprot id: B2RH64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

431947:PGN RS03085
gene id: 431947:PGN_RS03085
uniprot id: B2RIH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

431947:PGN RS05290
gene id: 431947:PGN_RS05290
uniprot id: B2RJS9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

431947:PGN RS02945
gene id: 431947:PGN_RS02945
uniprot id: B2RIE2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS08875
gene id: 431947:PGN_RS08875
uniprot id: B2RLZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

431947:PGN RS08485
gene id: 431947:PGN_RS08485
uniprot id: B2RLR2
names: Similarity
messages: Belongs to the peptidase S41A family.

431947:PGN RS04270
gene id: 431947:PGN_RS04270
uniprot id: B2RJ68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

431947:PGN RS09575
gene id: 431947:PGN_RS09575
uniprot id: B2RME6
names: Similarity
messages: Belongs to the AIR synthase family.

431947:PGN RS00590
gene id: 431947:PGN_RS00590
uniprot id: B2RGZ9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

431947:PGN RS00475
gene id: 431947:PGN_RS00475
uniprot id: B2RGX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

431947:PGN RS07650
gene id: 431947:PGN_RS07650
uniprot id: B2RL78
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

431947:PGN RS03510
gene id: 431947:PGN_RS03510
uniprot id: B2RIR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

431947:PGN RS07030
gene id: 431947:PGN_RS07030
uniprot id: B2RKU8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

431947:PGN RS06210
gene id: 431947:PGN_RS06210
uniprot id: B2RKC2
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

431947:PGN RS05545
gene id: 431947:PGN_RS05545
uniprot id: B2RJY0
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

431947:PGN RS08140
gene id: 431947:PGN_RS08140
uniprot id: B2RLI6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

431947:PGN RS06930
gene id: 431947:PGN_RS06930
uniprot id: B2RKS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

431947:PGN RS05625
gene id: 431947:PGN_RS05625
uniprot id: B2RJZ6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

431947:PGN RS06030
gene id: 431947:PGN_RS06030
uniprot id: B2RK83
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

431947:PGN RS01225
gene id: 431947:PGN_RS01225
uniprot id: B2RHC8
names: Similarity
messages: Belongs to the ParB family.

431947:PGN RS07280
gene id: 431947:PGN_RS07280
uniprot id: B2RKZ9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

431947:PGN RS07750
gene id: 431947:PGN_RS07750
uniprot id: B2RLA4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS06505
gene id: 431947:PGN_RS06505
uniprot id: B2RKI6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

431947:PGN RS03160
gene id: 431947:PGN_RS03160
uniprot id: B2RII8
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS04020
gene id: 431947:PGN_RS04020
uniprot id: B2RJ16
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS05270
gene id: 431947:PGN_RS05270
uniprot id: B2RJS4
names: Similarity
messages: Belongs to the CapA family.

431947:PGN RS04615
gene id: 431947:PGN_RS04615
uniprot id: B2RJD9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

431947:PGN RS02240
gene id: 431947:PGN_RS02240
uniprot id: B2RHZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

431947:PGN RS09245
gene id: 431947:PGN_RS09245
uniprot id: B2RM77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

431947:PGN RS08740
gene id: 431947:PGN_RS08740
uniprot id: B2RLW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

431947:PGN RS08005
gene id: 431947:PGN_RS08005
uniprot id: B2RLF6
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS03545
gene id: 431947:PGN_RS03545
uniprot id: B2RIR8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

431947:PGN RS06780
gene id: 431947:PGN_RS06780
uniprot id: B2RJE5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS00745
gene id: 431947:PGN_RS00745
uniprot id: B2RH33
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS08965
gene id: 431947:PGN_RS08965
uniprot id: B2RM15
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

431947:PGN RS03070
gene id: 431947:PGN_RS03070
uniprot id: B2RIG7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

431947:PGN RS04220
gene id: 431947:PGN_RS04220
uniprot id: B2RJ57
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS05170
gene id: 431947:PGN_RS05170
uniprot id: B2RJQ2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS07705
gene id: 431947:PGN_RS07705
uniprot id: B2RL92
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily.

431947:PGN RS01880
gene id: 431947:PGN_RS01880
uniprot id: B2RHR8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

431947:PGN RS07415
gene id: 431947:PGN_RS07415
uniprot id: B2RL29
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

431947:PGN RS03145
gene id: 431947:PGN_RS03145
uniprot id: B2RII5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

431947:PGN RS02140
gene id: 431947:PGN_RS02140
uniprot id: B2RHX0
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS05165
gene id: 431947:PGN_RS05165
uniprot id: B2RJQ1
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS09120
gene id: 431947:PGN_RS09120
uniprot id: B2RM48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

431947:PGN RS07205
gene id: 431947:PGN_RS07205
uniprot id: B2RKY5
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS00135
gene id: 431947:PGN_RS00135
uniprot id: B2RGQ1
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS07880
gene id: 431947:PGN_RS07880
uniprot id: B2RLC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

431947:PGN RS07735
gene id: 431947:PGN_RS07735
uniprot id: B2RLA1
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS02740
gene id: 431947:PGN_RS02740
uniprot id: B2RIA1
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS09370
gene id: 431947:PGN_RS09370
uniprot id: B2RMA4
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

431947:PGN RS06610
gene id: 431947:PGN_RS06610
uniprot id: B2RKL1
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS10110
gene id: 431947:PGN_RS10110
uniprot id: B2RH62
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

431947:PGN RS08940
gene id: 431947:PGN_RS08940
uniprot id: B2RM09
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

431947:PGN RS05420
gene id: 431947:PGN_RS05420
uniprot id: B2RJV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

431947:PGN RS08455
gene id: 431947:PGN_RS08455
uniprot id: B2RLQ6
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

431947:PGN RS08745
gene id: 431947:PGN_RS08745
uniprot id: B2RLW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

431947:PGN RS06615
gene id: 431947:PGN_RS06615
uniprot id: B2RKL2
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

431947:PGN RS07710
gene id: 431947:PGN_RS07710
uniprot id: B2RL93
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS04645
gene id: 431947:PGN_RS04645
uniprot id: B2RJE4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

431947:PGN RS05330
gene id: 431947:PGN_RS05330
uniprot id: B2RJT7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

431947:PGN RS09450
gene id: 431947:PGN_RS09450
uniprot id: B2RMC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS05705
gene id: 431947:PGN_RS05705
uniprot id: B2RK13
names: Similarity
messages: Belongs to the phosphohexose mutase family.

431947:PGN RS01190
gene id: 431947:PGN_RS01190
uniprot id: B2RHC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

431947:PGN RS00545
gene id: 431947:PGN_RS00545
uniprot id: B2RGZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

431947:PGN RS08765
gene id: 431947:PGN_RS08765
uniprot id: B2RLX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

431947:PGN RS05520
gene id: 431947:PGN_RS05520
uniprot id: B2RJX5
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

431947:PGN RS05810
gene id: 431947:PGN_RS05810
uniprot id: B2RK32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

431947:PGN RS04910
gene id: 431947:PGN_RS04910
uniprot id: B2RJJ9
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS01995
gene id: 431947:PGN_RS01995
uniprot id: B2RHU2
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

431947:PGN RS07295
gene id: 431947:PGN_RS07295
uniprot id: B2RL02
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS03810
gene id: 431947:PGN_RS03810
uniprot id: B2RIX3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

431947:PGN RS07180
gene id: 431947:PGN_RS07180
uniprot id: B2RKY0
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS00060
gene id: 431947:PGN_RS00060
uniprot id: B2RGN5
names: Similarity
messages: Belongs to the ComB family.

431947:PGN RS07315
gene id: 431947:PGN_RS07315
uniprot id: B2RL07
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

431947:PGN RS01740
gene id: 431947:PGN_RS01740
uniprot id: B2RHP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

431947:PGN RS09020
gene id: 431947:PGN_RS09020
uniprot id: B2RM27
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

431947:PGN RS04730
gene id: 431947:PGN_RS04730
uniprot id: B2RJG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS03305
gene id: 431947:PGN_RS03305
uniprot id: B2RIL6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

431947:PGN RS07445
gene id: 431947:PGN_RS07445
uniprot id: B2RL38
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

431947:PGN RS09840
gene id: 431947:PGN_RS09840
uniprot id: B2RMJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

431947:PGN RS01735
gene id: 431947:PGN_RS01735
uniprot id: B2RHN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

431947:PGN RS00580
gene id: 431947:PGN_RS00580
uniprot id: B2RGZ6
names: Similarity
messages: Belongs to the peptidase C25 family.

431947:PGN RS02285
gene id: 431947:PGN_RS02285
uniprot id: B2RI01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

431947:PGN RS00400
gene id: 431947:PGN_RS00400
uniprot id: B2RGV8
names: Similarity
messages: Belongs to the type IA topoisomerase family.

431947:PGN RS02145
gene id: 431947:PGN_RS02145
uniprot id: B2RHX1
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS08190
gene id: 431947:PGN_RS08190
uniprot id: B2RLJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

431947:PGN RS09255
gene id: 431947:PGN_RS09255
uniprot id: B2RM79
names: Similarity
messages: Belongs to the phosphohexose mutase family.

431947:PGN RS09265
gene id: 431947:PGN_RS09265
uniprot id: B2RM82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

431947:PGN RS03135
gene id: 431947:PGN_RS03135
uniprot id: B2RII3
names: Similarity
messages: Belongs to the peptidase C25 family.

431947:PGN RS03725
gene id: 431947:PGN_RS03725
uniprot id: B2RIV5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

431947:PGN RS00090
gene id: 431947:PGN_RS00090
uniprot id: B2RGP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

431947:PGN RS08840
gene id: 431947:PGN_RS08840
uniprot id: B2RLY8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

431947:PGN RS08930
gene id: 431947:PGN_RS08930
uniprot id: B2RM07
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

431947:PGN RS05925
gene id: 431947:PGN_RS05925
uniprot id: B2RK57
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

431947:PGN RS07390
gene id: 431947:PGN_RS07390
uniprot id: B2RL24
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

431947:PGN RS07000
gene id: 431947:PGN_RS07000
uniprot id: B2RKU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C25 family.
messages: Secreted
messages: Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA (PubMed:9786913). Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (By similarity).

431947:PGN RS02645
gene id: 431947:PGN_RS02645
uniprot id: B2RI81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

431947:PGN RS04755
gene id: 431947:PGN_RS04755
uniprot id: B2RJG6
names: Similarity
messages: Belongs to the ribF family.

431947:PGN RS01285
gene id: 431947:PGN_RS01285
uniprot id: B2RHE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

431947:PGN RS07770
gene id: 431947:PGN_RS07770
uniprot id: B2RLA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

431947:PGN RS00660
gene id: 431947:PGN_RS00660
uniprot id: B2RH14
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

431947:PGN RS06770
gene id: 431947:PGN_RS06770
uniprot id: B2RKP2
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

431947:PGN RS04475
gene id: 431947:PGN_RS04475
uniprot id: B2RJB0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

431947:PGN RS02615
gene id: 431947:PGN_RS02615
uniprot id: B2RI73
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

431947:PGN RS03235
gene id: 431947:PGN_RS03235
uniprot id: B2RIK3
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

431947:PGN RS02185
gene id: 431947:PGN_RS02185
uniprot id: B2RHY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.
messages: Heterodimer of an alpha and a beta chain.

431947:PGN RS03230
gene id: 431947:PGN_RS03230
uniprot id: B2RIK2
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

431947:PGN RS03910
gene id: 431947:PGN_RS03910
uniprot id: B2RIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

431947:PGN RS06845
gene id: 431947:PGN_RS06845
uniprot id: B2RKR0
names: Similarity
messages: Belongs to the Skp family.

431947:PGN RS09535
gene id: 431947:PGN_RS09535
uniprot id: B2RMD7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

431947:PGN RS01650
gene id: 431947:PGN_RS01650
uniprot id: B2RHM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

431947:PGN RS02425
gene id: 431947:PGN_RS02425
uniprot id: B2RI34
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

431947:PGN RS07690
gene id: 431947:PGN_RS07690
uniprot id: B2RL89
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

431947:PGN RS08350
gene id: 431947:PGN_RS08350
uniprot id: B2RLN1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

431947:PGN RS07540
gene id: 431947:PGN_RS07540
uniprot id: B2RL54
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

431947:PGN RS03975
gene id: 431947:PGN_RS03975
uniprot id: B2RJ07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

431947:PGN RS08785
gene id: 431947:PGN_RS08785
uniprot id: B2RLX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

431947:PGN RS01635
gene id: 431947:PGN_RS01635
uniprot id: B2RHL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

431947:PGN RS09530
gene id: 431947:PGN_RS09530
uniprot id: B2RMD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

431947:PGN RS05660
gene id: 431947:PGN_RS05660
uniprot id: B2RK03
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

431947:PGN RS03050
gene id: 431947:PGN_RS03050
uniprot id: B2RIG3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

431947:PGN RS01290
gene id: 431947:PGN_RS01290
uniprot id: B2RHE1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

431947:PGN RS07155
gene id: 431947:PGN_RS07155
uniprot id: B2RKX5
names: Cofactor
messages: Binds 1 zinc ion per subunit.

431947:PGN RS00985
gene id: 431947:PGN_RS00985
uniprot id: B2RH84
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

431947:PGN RS07925
gene id: 431947:PGN_RS07925
uniprot id: B2RLE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

431947:PGN RS09105
gene id: 431947:PGN_RS09105
uniprot id: B2RJC0
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS06925
gene id: 431947:PGN_RS06925
uniprot id: B2RKS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

431947:PGN RS03395
gene id: 431947:PGN_RS03395
uniprot id: B2RIN5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

431947:PGN RS08010
gene id: 431947:PGN_RS08010
uniprot id: B2RLF7
names: Subcellular Location Annotation
messages: Membrane

431947:PGN RS04740
gene id: 431947:PGN_RS04740
uniprot id: B2RJG3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.