416348:HLAC RS02420
gene id: 416348:HLAC_RS02420
uniprot id: B9LT24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS11495
gene id: 416348:HLAC_RS11495
uniprot id: B9LS15
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

416348:HLAC RS11900
gene id: 416348:HLAC_RS11900
uniprot id: B9LSM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

416348:HLAC RS09095
gene id: 416348:HLAC_RS09095
uniprot id: B9LPX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Homodimer.

416348:HLAC RS10620
gene id: 416348:HLAC_RS10620
uniprot id: B9LR58
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

416348:HLAC RS12050
gene id: 416348:HLAC_RS12050
uniprot id: B9LSQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

416348:HLAC RS05100
gene id: 416348:HLAC_RS05100
uniprot id: B9LMP0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03945
gene id: 416348:HLAC_RS03945
uniprot id: B9LUR9
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS06970
gene id: 416348:HLAC_RS06970
uniprot id: B9LNQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

416348:HLAC RS07550
gene id: 416348:HLAC_RS07550
uniprot id: B9LP23
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS04075
gene id: 416348:HLAC_RS04075
uniprot id: B9LUU5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

416348:HLAC RS00505
gene id: 416348:HLAC_RS00505
uniprot id: B9LQV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

416348:HLAC RS16280
gene id: 416348:HLAC_RS16280
uniprot id: B9LWM6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

416348:HLAC RS02165
gene id: 416348:HLAC_RS02165
uniprot id: B9LSW4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS11885
gene id: 416348:HLAC_RS11885
uniprot id: B9LSM0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

416348:HLAC RS05455
gene id: 416348:HLAC_RS05455
uniprot id: B9LMW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

416348:HLAC RS04630
gene id: 416348:HLAC_RS04630
uniprot id: B9LME8
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

416348:HLAC RS16290
gene id: 416348:HLAC_RS16290
uniprot id: B9LWM8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

416348:HLAC RS00535
gene id: 416348:HLAC_RS00535
uniprot id: B9LQW1
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

416348:HLAC RS07720
gene id: 416348:HLAC_RS07720
uniprot id: B9LP55
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

416348:HLAC RS17135
gene id: 416348:HLAC_RS17135
uniprot id: B9LX59
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

416348:HLAC RS00095
gene id: 416348:HLAC_RS00095
uniprot id: B9LQM5
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

416348:HLAC RS02600
gene id: 416348:HLAC_RS02600
uniprot id: B9LTJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

416348:HLAC RS11520
gene id: 416348:HLAC_RS11520
uniprot id: B9LS20
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

416348:HLAC RS01965
gene id: 416348:HLAC_RS01965
uniprot id: B9LST5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS02480
gene id: 416348:HLAC_RS02480
uniprot id: B9LT36
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

416348:HLAC RS16545
gene id: 416348:HLAC_RS16545
uniprot id: B9LWT4
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS01070
gene id: 416348:HLAC_RS01070
uniprot id: B9LRJ7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

416348:HLAC RS14095
gene id: 416348:HLAC_RS14095
uniprot id: B9LW21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

416348:HLAC RS01440
gene id: 416348:HLAC_RS01440
uniprot id: B9LS51
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

416348:HLAC RS14535
gene id: 416348:HLAC_RS14535
uniprot id: B9LWA5
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.

416348:HLAC RS03215
gene id: 416348:HLAC_RS03215
uniprot id: B9LTW6
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10805
gene id: 416348:HLAC_RS10805
uniprot id: B9LR98
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

416348:HLAC RS01225
gene id: 416348:HLAC_RS01225
uniprot id: B9LRM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS01250
gene id: 416348:HLAC_RS01250
uniprot id: B9LRN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS05355
gene id: 416348:HLAC_RS05355
uniprot id: B9LMU0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

416348:HLAC RS05035
gene id: 416348:HLAC_RS05035
uniprot id: B9LMM8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

416348:HLAC RS04460
gene id: 416348:HLAC_RS04460
uniprot id: B9LV23
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

416348:HLAC RS10220
gene id: 416348:HLAC_RS10220
uniprot id: B9LQL2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS09770
gene id: 416348:HLAC_RS09770
uniprot id: B9LQC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

416348:HLAC RS15955
gene id: 416348:HLAC_RS15955
uniprot id: B9LWF7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

416348:HLAC RS01695
gene id: 416348:HLAC_RS01695
uniprot id: B9LSA2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

416348:HLAC RS12970
gene id: 416348:HLAC_RS12970
uniprot id: B9LTY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

416348:HLAC RS16165
gene id: 416348:HLAC_RS16165
uniprot id: B9LWK1
names: Caution
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS01400
gene id: 416348:HLAC_RS01400
uniprot id: B9LS42
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

416348:HLAC RS09775
gene id: 416348:HLAC_RS09775
uniprot id: B9LQC3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

416348:HLAC RS04515
gene id: 416348:HLAC_RS04515
uniprot id: B9LMC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS13195
gene id: 416348:HLAC_RS13195
uniprot id: B9LU36
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

416348:HLAC RS02100
gene id: 416348:HLAC_RS02100
uniprot id: B9LSW1
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03405
gene id: 416348:HLAC_RS03405
uniprot id: B9LUD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

416348:HLAC RS04625
gene id: 416348:HLAC_RS04625
uniprot id: B9LME7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Cytoplasm

416348:HLAC RS05335
gene id: 416348:HLAC_RS05335
uniprot id: B9LMT6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

416348:HLAC RS10565
gene id: 416348:HLAC_RS10565
uniprot id: B9LR47
names: Similarity
messages: Belongs to the thioesterase PaaI family.

416348:HLAC RS00350
gene id: 416348:HLAC_RS00350
uniprot id: B9LQS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS01840
gene id: 416348:HLAC_RS01840
uniprot id: B9LSC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.

416348:HLAC RS05750
gene id: 416348:HLAC_RS05750
uniprot id: B9LN17
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10960
gene id: 416348:HLAC_RS10960
uniprot id: B9LRR0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

416348:HLAC RS03540
gene id: 416348:HLAC_RS03540
uniprot id: B9LUF9
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10170
gene id: 416348:HLAC_RS10170
uniprot id: B9LQK2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

416348:HLAC RS12980
gene id: 416348:HLAC_RS12980
uniprot id: B9LTZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS07675
gene id: 416348:HLAC_RS07675
uniprot id: B9LP47
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

416348:HLAC RS00345
gene id: 416348:HLAC_RS00345
uniprot id: B9LQS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS13015
gene id: 416348:HLAC_RS13015
uniprot id: B9LTZ8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS08970
gene id: 416348:HLAC_RS08970
uniprot id: B9LPU9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

416348:HLAC RS13565
gene id: 416348:HLAC_RS13565
uniprot id: B9LUN5
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS09025
gene id: 416348:HLAC_RS09025
uniprot id: B9LPV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

416348:HLAC RS01690
gene id: 416348:HLAC_RS01690
uniprot id: B9LSA1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

416348:HLAC RS04655
gene id: 416348:HLAC_RS04655
uniprot id: B9LMF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

416348:HLAC RS12795
gene id: 416348:HLAC_RS12795
uniprot id: B9LTH7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

416348:HLAC RS06605
gene id: 416348:HLAC_RS06605
uniprot id: B9LNI7
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS00005
gene id: 416348:HLAC_RS00005
uniprot id: B9LQ73
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

416348:HLAC RS11020
gene id: 416348:HLAC_RS11020
uniprot id: B9LRS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

416348:HLAC RS05255
gene id: 416348:HLAC_RS05255
uniprot id: B9LMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

416348:HLAC RS14425
gene id: 416348:HLAC_RS14425
uniprot id: B9LW84
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS01185
gene id: 416348:HLAC_RS01185
uniprot id: B9LRM0
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

416348:HLAC RS10095
gene id: 416348:HLAC_RS10095
uniprot id: B9LQI7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

416348:HLAC RS13525
gene id: 416348:HLAC_RS13525
uniprot id: B9LUM7
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS12485
gene id: 416348:HLAC_RS12485
uniprot id: B9LTB7
names: Similarity
messages: Belongs to the pirin family.

416348:HLAC RS10925
gene id: 416348:HLAC_RS10925
uniprot id: B9LRQ3
names: Similarity
messages: Belongs to the HAM1 NTPase family.

416348:HLAC RS12660
gene id: 416348:HLAC_RS12660
uniprot id: B9LTF1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

416348:HLAC RS02640
gene id: 416348:HLAC_RS02640
uniprot id: B9LTJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

416348:HLAC RS01670
gene id: 416348:HLAC_RS01670
uniprot id: B9LS97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

416348:HLAC RS10020
gene id: 416348:HLAC_RS10020
uniprot id: B9LQH2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

416348:HLAC RS11260
gene id: 416348:HLAC_RS11260
uniprot id: B9LRW8
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

416348:HLAC RS08540
gene id: 416348:HLAC_RS08540
uniprot id: B9LPL5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS09000
gene id: 416348:HLAC_RS09000
uniprot id: B9LPV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

416348:HLAC RS06330
gene id: 416348:HLAC_RS06330
uniprot id: B9LND0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10235
gene id: 416348:HLAC_RS10235
uniprot id: B9LQL5
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS13110
gene id: 416348:HLAC_RS13110
uniprot id: B9LU18
names: Similarity
messages: Belongs to the band 7/mec-2 family.

416348:HLAC RS02425
gene id: 416348:HLAC_RS02425
uniprot id: B9LT25
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS01410
gene id: 416348:HLAC_RS01410
uniprot id: B9LS45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS09510
gene id: 416348:HLAC_RS09510
uniprot id: B9LQ53
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS08100
gene id: 416348:HLAC_RS08100
uniprot id: B9LPC8
names: Similarity
messages: Belongs to the SCO1/2 family.

416348:HLAC RS07025
gene id: 416348:HLAC_RS07025
uniprot id: B9LNR6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS12135
gene id: 416348:HLAC_RS12135
uniprot id: B9LSS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS07445
gene id: 416348:HLAC_RS07445
uniprot id: B9LP05
names: Similarity
messages: Belongs to the disproportionating enzyme family.

416348:HLAC RS08825
gene id: 416348:HLAC_RS08825
uniprot id: B9LPR8
names: Similarity
messages: Belongs to the glutaredoxin family.

416348:HLAC RS07360
gene id: 416348:HLAC_RS07360
uniprot id: B9LNY7
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Belongs to the isochorismate synthase family.

416348:HLAC RS17185
gene id: 416348:HLAC_RS17185
uniprot id: B9LX70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS11320
gene id: 416348:HLAC_RS11320
uniprot id: B9LRY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

416348:HLAC RS13125
gene id: 416348:HLAC_RS13125
uniprot id: B9LU21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS06300
gene id: 416348:HLAC_RS06300
uniprot id: B9LNC4
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

416348:HLAC RS09250
gene id: 416348:HLAC_RS09250
uniprot id: B9LQ01
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

416348:HLAC RS14165
gene id: 416348:HLAC_RS14165
uniprot id: B9LW35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS01945
gene id: 416348:HLAC_RS01945
uniprot id: B9LSF1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

416348:HLAC RS16725
gene id: 416348:HLAC_RS16725
uniprot id: B9LWX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS01035
gene id: 416348:HLAC_RS01035
uniprot id: B9LRJ0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS06180
gene id: 416348:HLAC_RS06180
uniprot id: B9LNA1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS07395
gene id: 416348:HLAC_RS07395
uniprot id: B9LNZ5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

416348:HLAC RS00810
gene id: 416348:HLAC_RS00810
uniprot id: B9LRE2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03885
gene id: 416348:HLAC_RS03885
uniprot id: B9LUQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

416348:HLAC RS03455
gene id: 416348:HLAC_RS03455
uniprot id: B9LUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

416348:HLAC RS02935
gene id: 416348:HLAC_RS02935
uniprot id: B9LTQ9
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

416348:HLAC RS08350
gene id: 416348:HLAC_RS08350
uniprot id: B9LPH6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

416348:HLAC RS10430
gene id: 416348:HLAC_RS10430
uniprot id: B9LR20
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS06280
gene id: 416348:HLAC_RS06280
uniprot id: B9LNC0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS12120
gene id: 416348:HLAC_RS12120
uniprot id: B9LSR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS12035
gene id: 416348:HLAC_RS12035
uniprot id: B9LSQ1
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS05950
gene id: 416348:HLAC_RS05950
uniprot id: B9LN57
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

416348:HLAC RS02790
gene id: 416348:HLAC_RS02790
uniprot id: B9LTN0
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

416348:HLAC RS11815
gene id: 416348:HLAC_RS11815
uniprot id: B9LSK5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

416348:HLAC RS07560
gene id: 416348:HLAC_RS07560
uniprot id: B9LP25
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

416348:HLAC RS03460
gene id: 416348:HLAC_RS03460
uniprot id: B9LUE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS15870
gene id: 416348:HLAC_RS15870
uniprot id: B9LVR4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

416348:HLAC RS04390
gene id: 416348:HLAC_RS04390
uniprot id: B9LV08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

416348:HLAC RS07410
gene id: 416348:HLAC_RS07410
uniprot id: B9LNZ8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

416348:HLAC RS08520
gene id: 416348:HLAC_RS08520
uniprot id: B9LPL1
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

416348:HLAC RS05380
gene id: 416348:HLAC_RS05380
uniprot id: B9LMU5
names: Similarity
messages: Belongs to the PrpD family.

416348:HLAC RS01240
gene id: 416348:HLAC_RS01240
uniprot id: B9LRN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS06250
gene id: 416348:HLAC_RS06250
uniprot id: B9LNB4
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS00515
gene id: 416348:HLAC_RS00515
uniprot id: B9LQV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

416348:HLAC RS09115
gene id: 416348:HLAC_RS09115
uniprot id: B9LPX5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

416348:HLAC RS03490
gene id: 416348:HLAC_RS03490
uniprot id: B9LUE9
names: Similarity
messages: Belongs to the complex I subunit 3 family.

416348:HLAC RS07330
gene id: 416348:HLAC_RS07330
uniprot id: B9LNY0
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

416348:HLAC RS01865
gene id: 416348:HLAC_RS01865
uniprot id: B9LSD5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS14540
gene id: 416348:HLAC_RS14540
uniprot id: B9LWA6
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

416348:HLAC RS04705
gene id: 416348:HLAC_RS04705
uniprot id: B9LMG3
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11190
gene id: 416348:HLAC_RS11190
uniprot id: B9LRV4
names: Similarity
messages: Belongs to the HMBS family.

416348:HLAC RS11730
gene id: 416348:HLAC_RS11730
uniprot id: B9LSI8
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS08090
gene id: 416348:HLAC_RS08090
uniprot id: B9LPC6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

416348:HLAC RS06365
gene id: 416348:HLAC_RS06365
uniprot id: B9LND9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

416348:HLAC RS07780
gene id: 416348:HLAC_RS07780
uniprot id: B9LP66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

416348:HLAC RS01380
gene id: 416348:HLAC_RS01380
uniprot id: B9LS38
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

416348:HLAC RS11770
gene id: 416348:HLAC_RS11770
uniprot id: B9LSJ6
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

416348:HLAC RS10435
gene id: 416348:HLAC_RS10435
uniprot id: B9LR21
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03950
gene id: 416348:HLAC_RS03950
uniprot id: B9LUS0
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

416348:HLAC RS00725
gene id: 416348:HLAC_RS00725
uniprot id: B9LRC5
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

416348:HLAC RS15930
gene id: 416348:HLAC_RS15930
uniprot id: B9LWF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS07725
gene id: 416348:HLAC_RS07725
uniprot id: B9LP56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

416348:HLAC RS08200
gene id: 416348:HLAC_RS08200
uniprot id: B9LPE7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

416348:HLAC RS04825
gene id: 416348:HLAC_RS04825
uniprot id: B9LMI7
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS12090
gene id: 416348:HLAC_RS12090
uniprot id: B9LSR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS04170
gene id: 416348:HLAC_RS04170
uniprot id: B9LUW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS04325
gene id: 416348:HLAC_RS04325
uniprot id: B9LUZ5
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

416348:HLAC RS09055
gene id: 416348:HLAC_RS09055
uniprot id: B9LPW3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

416348:HLAC RS14200
gene id: 416348:HLAC_RS14200
uniprot id: B9LW42
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS00370
gene id: 416348:HLAC_RS00370
uniprot id: B9LQS6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

416348:HLAC RS05015
gene id: 416348:HLAC_RS05015
uniprot id: B9LMM4
names: Similarity
messages: Belongs to the UPF0145 family.

416348:HLAC RS06455
gene id: 416348:HLAC_RS06455
uniprot id: B9LNF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

416348:HLAC RS05865
gene id: 416348:HLAC_RS05865
uniprot id: B9LN40
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11985
gene id: 416348:HLAC_RS11985
uniprot id: B9LSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

416348:HLAC RS08180
gene id: 416348:HLAC_RS08180
uniprot id: B9LPE3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

416348:HLAC RS12330
gene id: 416348:HLAC_RS12330
uniprot id: B9LT85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS12165
gene id: 416348:HLAC_RS12165
uniprot id: B9LSS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

416348:HLAC RS00560
gene id: 416348:HLAC_RS00560
uniprot id: B9LQW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

416348:HLAC RS11535
gene id: 416348:HLAC_RS11535
uniprot id: B9LS23
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

416348:HLAC RS04790
gene id: 416348:HLAC_RS04790
uniprot id: B9LMI0
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

416348:HLAC RS02845
gene id: 416348:HLAC_RS02845
uniprot id: B9LTP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

416348:HLAC RS01590
gene id: 416348:HLAC_RS01590
uniprot id: B9LS82
names: Subcellular Location Annotation
messages: Cytoplasm

416348:HLAC RS07850
gene id: 416348:HLAC_RS07850
uniprot id: B9LP79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

416348:HLAC RS07450
gene id: 416348:HLAC_RS07450
uniprot id: B9LP06
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11805
gene id: 416348:HLAC_RS11805
uniprot id: B9LSK3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

416348:HLAC RS12750
gene id: 416348:HLAC_RS12750
uniprot id: B9LTG9
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS00425
gene id: 416348:HLAC_RS00425
uniprot id: B9LQT7
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS12305
gene id: 416348:HLAC_RS12305
uniprot id: B9LT79
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

416348:HLAC RS09060
gene id: 416348:HLAC_RS09060
uniprot id: B9LPW4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

416348:HLAC RS09030
gene id: 416348:HLAC_RS09030
uniprot id: B9LPV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS08075
gene id: 416348:HLAC_RS08075
uniprot id: B9LPC3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

416348:HLAC RS07700
gene id: 416348:HLAC_RS07700
uniprot id: B9LP51
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group I subfamily.

416348:HLAC RS04345
gene id: 416348:HLAC_RS04345
uniprot id: B9LUZ9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

416348:HLAC RS11275
gene id: 416348:HLAC_RS11275
uniprot id: B9LRX1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

416348:HLAC RS07020
gene id: 416348:HLAC_RS07020
uniprot id: B9LNR5
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11540
gene id: 416348:HLAC_RS11540
uniprot id: B9LS24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

416348:HLAC RS07040
gene id: 416348:HLAC_RS07040
uniprot id: B9LNR9
names: Similarity
messages: Belongs to the acylphosphatase family.

416348:HLAC RS03525
gene id: 416348:HLAC_RS03525
uniprot id: B9LUF6
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03845
gene id: 416348:HLAC_RS03845
uniprot id: B9LUM0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

416348:HLAC RS03305
gene id: 416348:HLAC_RS03305
uniprot id: B9LUB2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

416348:HLAC RS01680
gene id: 416348:HLAC_RS01680
uniprot id: B9LS99
names: Similarity
messages: Belongs to the HerA family.

416348:HLAC RS06310
gene id: 416348:HLAC_RS06310
uniprot id: B9LNC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

416348:HLAC RS00365
gene id: 416348:HLAC_RS00365
uniprot id: B9LQS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

416348:HLAC RS05365
gene id: 416348:HLAC_RS05365
uniprot id: B9LMU2
names: Caution
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS04100
gene id: 416348:HLAC_RS04100
uniprot id: B9LUV0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

416348:HLAC RS15925
gene id: 416348:HLAC_RS15925
uniprot id: B9LWF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS12215
gene id: 416348:HLAC_RS12215
uniprot id: B9LT61
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS01675
gene id: 416348:HLAC_RS01675
uniprot id: B9LS98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

416348:HLAC RS04835
gene id: 416348:HLAC_RS04835
uniprot id: B9LMI9
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS09995
gene id: 416348:HLAC_RS09995
uniprot id: B9LQG7
names: Similarity
messages: Belongs to the PdaD family.

416348:HLAC RS16775
gene id: 416348:HLAC_RS16775
uniprot id: B9LWY1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

416348:HLAC RS00860
gene id: 416348:HLAC_RS00860
uniprot id: B9LRF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

416348:HLAC RS09435
gene id: 416348:HLAC_RS09435
uniprot id: B9LQ38
names: Subcellular Location Annotation
messages: Cell membrane

416348:HLAC RS16195
gene id: 416348:HLAC_RS16195
uniprot id: B9LWK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

416348:HLAC RS06335
gene id: 416348:HLAC_RS06335
uniprot id: B9LND1
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

416348:HLAC RS13530
gene id: 416348:HLAC_RS13530
uniprot id: B9LUM8
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

416348:HLAC RS09975
gene id: 416348:HLAC_RS09975
uniprot id: B9LQG3
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS09070
gene id: 416348:HLAC_RS09070
uniprot id: B9LPW6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

416348:HLAC RS11060
gene id: 416348:HLAC_RS11060
uniprot id: B9LRT0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

416348:HLAC RS05600
gene id: 416348:HLAC_RS05600
uniprot id: B9LMY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

416348:HLAC RS08455
gene id: 416348:HLAC_RS08455
uniprot id: B9LPJ7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

416348:HLAC RS09050
gene id: 416348:HLAC_RS09050
uniprot id: B9LPW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

416348:HLAC RS09640
gene id: 416348:HLAC_RS09640
uniprot id: B9LQ96
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

416348:HLAC RS13020
gene id: 416348:HLAC_RS13020
uniprot id: B9LTZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

416348:HLAC RS15410
gene id: 416348:HLAC_RS15410
uniprot id: B9LVG5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

416348:HLAC RS13385
gene id: 416348:HLAC_RS13385
uniprot id: B9LU73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS04440
gene id: 416348:HLAC_RS04440
uniprot id: B9LV19
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS11780
gene id: 416348:HLAC_RS11780
uniprot id: B9LSJ8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

416348:HLAC RS09090
gene id: 416348:HLAC_RS09090
uniprot id: B9LPX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

416348:HLAC RS09940
gene id: 416348:HLAC_RS09940
uniprot id: B9LQF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

416348:HLAC RS10245
gene id: 416348:HLAC_RS10245
uniprot id: B9LQL7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

416348:HLAC RS13070
gene id: 416348:HLAC_RS13070
uniprot id: B9LU09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

416348:HLAC RS00720
gene id: 416348:HLAC_RS00720
uniprot id: B9LRC4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

416348:HLAC RS04990
gene id: 416348:HLAC_RS04990
uniprot id: B9LML9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

416348:HLAC RS05875
gene id: 416348:HLAC_RS05875
uniprot id: B9LN42
names: Function
messages: Part of a potassium transport system.

416348:HLAC RS02205
gene id: 416348:HLAC_RS02205
uniprot id: B9LSY1
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS02970
gene id: 416348:HLAC_RS02970
uniprot id: B9LTR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

416348:HLAC RS00910
gene id: 416348:HLAC_RS00910
uniprot id: B9LRG3
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

416348:HLAC RS14120
gene id: 416348:HLAC_RS14120
uniprot id: B9LW25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS09415
gene id: 416348:HLAC_RS09415
uniprot id: B9LQ34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

416348:HLAC RS09165
gene id: 416348:HLAC_RS09165
uniprot id: B9LPY4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

416348:HLAC RS09020
gene id: 416348:HLAC_RS09020
uniprot id: B9LPV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

416348:HLAC RS15640
gene id: 416348:HLAC_RS15640
uniprot id: B9LVL4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

416348:HLAC RS07055
gene id: 416348:HLAC_RS07055
uniprot id: B9LNS2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS05550
gene id: 416348:HLAC_RS05550
uniprot id: B9LMX8
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS11600
gene id: 416348:HLAC_RS11600
uniprot id: B9LSG3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS08670
gene id: 416348:HLAC_RS08670
uniprot id: B9LPP0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS16680
gene id: 416348:HLAC_RS16680
uniprot id: B9LWW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

416348:HLAC RS09240
gene id: 416348:HLAC_RS09240
uniprot id: B9LPZ9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS05360
gene id: 416348:HLAC_RS05360
uniprot id: B9LMU1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

416348:HLAC RS10205
gene id: 416348:HLAC_RS10205
uniprot id: B9LQK9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

416348:HLAC RS03250
gene id: 416348:HLAC_RS03250
uniprot id: B9LUA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

416348:HLAC RS00200
gene id: 416348:HLAC_RS00200
uniprot id: B9LQP4
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

416348:HLAC RS04760
gene id: 416348:HLAC_RS04760
uniprot id: B9LMH4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

416348:HLAC RS05385
gene id: 416348:HLAC_RS05385
uniprot id: B9LMU6
names: Similarity
messages: Belongs to the PrpD family.

416348:HLAC RS01220
gene id: 416348:HLAC_RS01220
uniprot id: B9LRM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS14770
gene id: 416348:HLAC_RS14770
uniprot id: B9LV30
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

416348:HLAC RS06400
gene id: 416348:HLAC_RS06400
uniprot id: B9LNE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

416348:HLAC RS09935
gene id: 416348:HLAC_RS09935
uniprot id: B9LQF5
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

416348:HLAC RS04445
gene id: 416348:HLAC_RS04445
uniprot id: B9LV20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

416348:HLAC RS16205
gene id: 416348:HLAC_RS16205
uniprot id: B9LWK8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

416348:HLAC RS04355
gene id: 416348:HLAC_RS04355
uniprot id: B9LV01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

416348:HLAC RS09225
gene id: 416348:HLAC_RS09225
uniprot id: B9LPZ6
names: Similarity
messages: Belongs to the UPF0201 family.

416348:HLAC RS01875
gene id: 416348:HLAC_RS01875
uniprot id: B9LSD7
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

416348:HLAC RS04755
gene id: 416348:HLAC_RS04755
uniprot id: B9LMH3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

416348:HLAC RS02800
gene id: 416348:HLAC_RS02800
uniprot id: B9LTN2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

416348:HLAC RS12405
gene id: 416348:HLAC_RS12405
uniprot id: B9LTA1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

416348:HLAC RS04980
gene id: 416348:HLAC_RS04980
uniprot id: B9LML7
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

416348:HLAC RS10465
gene id: 416348:HLAC_RS10465
uniprot id: B9LR27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

416348:HLAC RS03585
gene id: 416348:HLAC_RS03585
uniprot id: B9LUG8
names: Similarity
messages: Belongs to the citrate synthase family.

416348:HLAC RS03555
gene id: 416348:HLAC_RS03555
uniprot id: B9LUG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

416348:HLAC RS04025
gene id: 416348:HLAC_RS04025
uniprot id: B9LUT5
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

416348:HLAC RS10820
gene id: 416348:HLAC_RS10820
uniprot id: B9LRA1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS00665
gene id: 416348:HLAC_RS00665
uniprot id: B9LQY4
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS05915
gene id: 416348:HLAC_RS05915
uniprot id: B9LN50
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04365
gene id: 416348:HLAC_RS04365
uniprot id: B9LV03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS00305
gene id: 416348:HLAC_RS00305
uniprot id: B9LQR3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

416348:HLAC RS13655
gene id: 416348:HLAC_RS13655
uniprot id: B9LVS8
names: Caution
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS03165
gene id: 416348:HLAC_RS03165
uniprot id: B9LTV5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

416348:HLAC RS02400
gene id: 416348:HLAC_RS02400
uniprot id: B9LT20
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS05090
gene id: 416348:HLAC_RS05090
uniprot id: B9LMN8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

416348:HLAC RS10040
gene id: 416348:HLAC_RS10040
uniprot id: B9LQH6
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

416348:HLAC RS07155
gene id: 416348:HLAC_RS07155
uniprot id: B9LNU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

416348:HLAC RS14690
gene id: 416348:HLAC_RS14690
uniprot id: B9LWD6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS13535
gene id: 416348:HLAC_RS13535
uniprot id: B9LUM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

416348:HLAC RS10995
gene id: 416348:HLAC_RS10995
uniprot id: B9LRR7
names: Similarity
messages: Belongs to the UPF0175 family.

416348:HLAC RS05445
gene id: 416348:HLAC_RS05445
uniprot id: B9LMV8
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

416348:HLAC RS06860
gene id: 416348:HLAC_RS06860
uniprot id: B9LNN3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

416348:HLAC RS08055
gene id: 416348:HLAC_RS08055
uniprot id: B9LPB9
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

416348:HLAC RS01425
gene id: 416348:HLAC_RS01425
uniprot id: B9LS48
names: Similarity
messages: Belongs to the DNA photolyase family.

416348:HLAC RS13130
gene id: 416348:HLAC_RS13130
uniprot id: B9LU22
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

416348:HLAC RS08065
gene id: 416348:HLAC_RS08065
uniprot id: B9LPC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

416348:HLAC RS07015
gene id: 416348:HLAC_RS07015
uniprot id: B9LNR4
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS13495
gene id: 416348:HLAC_RS13495
uniprot id: B9LUM1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

416348:HLAC RS08985
gene id: 416348:HLAC_RS08985
uniprot id: B9LPV2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03325
gene id: 416348:HLAC_RS03325
uniprot id: B9LUB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS11525
gene id: 416348:HLAC_RS11525
uniprot id: B9LS21
names: Similarity
messages: Belongs to the UPF0179 family.

416348:HLAC RS15170
gene id: 416348:HLAC_RS15170
uniprot id: B9LVB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

416348:HLAC RS05125
gene id: 416348:HLAC_RS05125
uniprot id: B9LMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

416348:HLAC RS00450
gene id: 416348:HLAC_RS00450
uniprot id: B9LQU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

416348:HLAC RS02115
gene id: 416348:HLAC_RS02115
uniprot id: B9LSW4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS08010
gene id: 416348:HLAC_RS08010
uniprot id: B9LPB0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

416348:HLAC RS08005
gene id: 416348:HLAC_RS08005
uniprot id: B9LPA9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

416348:HLAC RS13370
gene id: 416348:HLAC_RS13370
uniprot id: B9LU70
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS06840
gene id: 416348:HLAC_RS06840
uniprot id: B9LNM9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

416348:HLAC RS04415
gene id: 416348:HLAC_RS04415
uniprot id: B9LV13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

416348:HLAC RS03505
gene id: 416348:HLAC_RS03505
uniprot id: B9LUF2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS12555
gene id: 416348:HLAC_RS12555
uniprot id: B9LTD0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

416348:HLAC RS10770
gene id: 416348:HLAC_RS10770
uniprot id: B9LR90
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

416348:HLAC RS02780
gene id: 416348:HLAC_RS02780
uniprot id: B9LTM8
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS07555
gene id: 416348:HLAC_RS07555
uniprot id: B9LP24
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

416348:HLAC RS13150
gene id: 416348:HLAC_RS13150
uniprot id: B9LU26
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

416348:HLAC RS02660
gene id: 416348:HLAC_RS02660
uniprot id: B9LTK4
names: Similarity
messages: Belongs to the Dps family.

416348:HLAC RS04610
gene id: 416348:HLAC_RS04610
uniprot id: B9LME4
names: Similarity
messages: Belongs to the arginase family.

416348:HLAC RS04165
gene id: 416348:HLAC_RS04165
uniprot id: B9LUW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS12065
gene id: 416348:HLAC_RS12065
uniprot id: B9LSQ7
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

416348:HLAC RS02510
gene id: 416348:HLAC_RS02510
uniprot id: B9LT42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS08490
gene id: 416348:HLAC_RS08490
uniprot id: B9LPK3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

416348:HLAC RS10055
gene id: 416348:HLAC_RS10055
uniprot id: B9LQH9
names: Similarity
messages: Belongs to the archease family.

416348:HLAC RS12880
gene id: 416348:HLAC_RS12880
uniprot id: B9LTX2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS11210
gene id: 416348:HLAC_RS11210
uniprot id: B9LRV8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

416348:HLAC RS07325
gene id: 416348:HLAC_RS07325
uniprot id: B9LNX9
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

416348:HLAC RS15145
gene id: 416348:HLAC_RS15145
uniprot id: B9LVB0
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

416348:HLAC RS06835
gene id: 416348:HLAC_RS06835
uniprot id: B9LNM8
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS13030
gene id: 416348:HLAC_RS13030
uniprot id: B9LU01
names: Caution
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS12575
gene id: 416348:HLAC_RS12575
uniprot id: B9LTD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

416348:HLAC RS01465
gene id: 416348:HLAC_RS01465
uniprot id: B9LS56
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

416348:HLAC RS17180
gene id: 416348:HLAC_RS17180
uniprot id: B9LX69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

416348:HLAC RS05870
gene id: 416348:HLAC_RS05870
uniprot id: B9LN41
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS06650
gene id: 416348:HLAC_RS06650
uniprot id: B9LNJ6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

416348:HLAC RS11055
gene id: 416348:HLAC_RS11055
uniprot id: B9LRS9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

416348:HLAC RS00335
gene id: 416348:HLAC_RS00335
uniprot id: B9LQR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS01705
gene id: 416348:HLAC_RS01705
uniprot id: B9LSA4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

416348:HLAC RS02265
gene id: 416348:HLAC_RS02265
uniprot id: B9LSZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

416348:HLAC RS16385
gene id: 416348:HLAC_RS16385
uniprot id: B9LWQ0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

416348:HLAC RS08995
gene id: 416348:HLAC_RS08995
uniprot id: B9LPV3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

416348:HLAC RS03310
gene id: 416348:HLAC_RS03310
uniprot id: B9LUB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

416348:HLAC RS12975
gene id: 416348:HLAC_RS12975
uniprot id: B9LTZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

416348:HLAC RS08965
gene id: 416348:HLAC_RS08965
uniprot id: B9LPU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS02620
gene id: 416348:HLAC_RS02620
uniprot id: B9LTJ5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for chromosome condensation and partitioning.

416348:HLAC RS02650
gene id: 416348:HLAC_RS02650
uniprot id: B9LTK1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

416348:HLAC RS13945
gene id: 416348:HLAC_RS13945
uniprot id: B9LVZ5
names: Similarity
messages: Belongs to the TBP family.

416348:HLAC RS06350
gene id: 416348:HLAC_RS06350
uniprot id: B9LND5
names: Similarity
messages: Belongs to the threonine aldolase family.

416348:HLAC RS12115
gene id: 416348:HLAC_RS12115
uniprot id: B9LSR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

416348:HLAC RS14545
gene id: 416348:HLAC_RS14545
uniprot id: B9LWA7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

416348:HLAC RS05675
gene id: 416348:HLAC_RS05675
uniprot id: B9LN02
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS12990
gene id: 416348:HLAC_RS12990
uniprot id: B9LTZ3
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

416348:HLAC RS12780
gene id: 416348:HLAC_RS12780
uniprot id: B9LTH4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

416348:HLAC RS07480
gene id: 416348:HLAC_RS07480
uniprot id: B9LP13
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

416348:HLAC RS00770
gene id: 416348:HLAC_RS00770
uniprot id: B9LRD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

416348:HLAC RS12950
gene id: 416348:HLAC_RS12950
uniprot id: B9LTY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS05650
gene id: 416348:HLAC_RS05650
uniprot id: B9LMZ7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

416348:HLAC RS04315
gene id: 416348:HLAC_RS04315
uniprot id: B9LUZ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

416348:HLAC RS11865
gene id: 416348:HLAC_RS11865
uniprot id: B9LSL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS06480
gene id: 416348:HLAC_RS06480
uniprot id: B9LNG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

416348:HLAC RS11265
gene id: 416348:HLAC_RS11265
uniprot id: B9LRW9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

416348:HLAC RS02180
gene id: 416348:HLAC_RS02180
uniprot id: B9LSX6
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS15600
gene id: 416348:HLAC_RS15600
uniprot id: B9LVK8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

416348:HLAC RS09155
gene id: 416348:HLAC_RS09155
uniprot id: B9LPY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

416348:HLAC RS00855
gene id: 416348:HLAC_RS00855
uniprot id: B9LRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

416348:HLAC RS02675
gene id: 416348:HLAC_RS02675
uniprot id: B9LTK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

416348:HLAC RS08235
gene id: 416348:HLAC_RS08235
uniprot id: B9LPF4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS15000
gene id: 416348:HLAC_RS15000
uniprot id: B9LV77
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

416348:HLAC RS06555
gene id: 416348:HLAC_RS06555
uniprot id: B9LNH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

416348:HLAC RS06215
gene id: 416348:HLAC_RS06215
uniprot id: B9LNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

416348:HLAC RS16010
gene id: 416348:HLAC_RS16010
uniprot id: B9LWH2
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS04320
gene id: 416348:HLAC_RS04320
uniprot id: B9LUZ4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS11785
gene id: 416348:HLAC_RS11785
uniprot id: B9LSJ9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

416348:HLAC RS10260
gene id: 416348:HLAC_RS10260
uniprot id: B9LQM0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS11410
gene id: 416348:HLAC_RS11410
uniprot id: B9LRZ8
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS07415
gene id: 416348:HLAC_RS07415
uniprot id: B9LNZ9
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS13055
gene id: 416348:HLAC_RS13055
uniprot id: B9LU06
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS13090
gene id: 416348:HLAC_RS13090
uniprot id: B9LU14
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

416348:HLAC RS04120
gene id: 416348:HLAC_RS04120
uniprot id: B9LUV4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS13625
gene id: 416348:HLAC_RS13625
uniprot id: B9LUP7
names: Similarity
messages: Belongs to the aspartokinase family.

416348:HLAC RS09630
gene id: 416348:HLAC_RS09630
uniprot id: B9LQ94
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

416348:HLAC RS17530
gene id: 416348:HLAC_RS17530
uniprot id: B9LXF2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

416348:HLAC RS00520
gene id: 416348:HLAC_RS00520
uniprot id: B9LQV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

416348:HLAC RS00795
gene id: 416348:HLAC_RS00795
uniprot id: B9LRD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS09475
gene id: 416348:HLAC_RS09475
uniprot id: B9LQ46
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

416348:HLAC RS07230
gene id: 416348:HLAC_RS07230
uniprot id: B9LNW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

416348:HLAC RS03620
gene id: 416348:HLAC_RS03620
uniprot id: B9LUH5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

416348:HLAC RS07610
gene id: 416348:HLAC_RS07610
uniprot id: B9LP35
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

416348:HLAC RS10585
gene id: 416348:HLAC_RS10585
uniprot id: B9LR51
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

416348:HLAC RS09780
gene id: 416348:HLAC_RS09780
uniprot id: B9LQC4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS00435
gene id: 416348:HLAC_RS00435
uniprot id: B9LQT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

416348:HLAC RS00390
gene id: 416348:HLAC_RS00390
uniprot id: B9LQT0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

416348:HLAC RS13000
gene id: 416348:HLAC_RS13000
uniprot id: B9LTZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

416348:HLAC RS04090
gene id: 416348:HLAC_RS04090
uniprot id: B9LUU8
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

416348:HLAC RS10910
gene id: 416348:HLAC_RS10910
uniprot id: B9LRP9
names: Similarity
messages: Belongs to the peptidase S8 family.

416348:HLAC RS07680
gene id: 416348:HLAC_RS07680
uniprot id: B9LP48
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS04310
gene id: 416348:HLAC_RS04310
uniprot id: B9LUZ2
names: Function
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

416348:HLAC RS01835
gene id: 416348:HLAC_RS01835
uniprot id: B9LSC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

416348:HLAC RS11240
gene id: 416348:HLAC_RS11240
uniprot id: B9LRW4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

416348:HLAC RS14505
gene id: 416348:HLAC_RS14505
uniprot id: B9LW99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS05685
gene id: 416348:HLAC_RS05685
uniprot id: B9LN04
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11835
gene id: 416348:HLAC_RS11835
uniprot id: B9LSK9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

416348:HLAC RS01120
gene id: 416348:HLAC_RS01120
uniprot id: B9LRK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS01295
gene id: 416348:HLAC_RS01295
uniprot id: B9LRP2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS09180
gene id: 416348:HLAC_RS09180
uniprot id: B9LPY7
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

416348:HLAC RS12220
gene id: 416348:HLAC_RS12220
uniprot id: B9LT62
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

416348:HLAC RS04750
gene id: 416348:HLAC_RS04750
uniprot id: B9LMH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

416348:HLAC RS11490
gene id: 416348:HLAC_RS11490
uniprot id: B9LS14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS08850
gene id: 416348:HLAC_RS08850
uniprot id: B9LPS3
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

416348:HLAC RS04775
gene id: 416348:HLAC_RS04775
uniprot id: B9LMH7
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

416348:HLAC RS08760
gene id: 416348:HLAC_RS08760
uniprot id: B9LPQ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

416348:HLAC RS00360
gene id: 416348:HLAC_RS00360
uniprot id: B9LQS4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

416348:HLAC RS01815
gene id: 416348:HLAC_RS01815
uniprot id: B9LSC4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

416348:HLAC RS08980
gene id: 416348:HLAC_RS08980
uniprot id: B9LPV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

416348:HLAC RS09410
gene id: 416348:HLAC_RS09410
uniprot id: B9LQ33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

416348:HLAC RS10950
gene id: 416348:HLAC_RS10950
uniprot id: B9LRQ8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

416348:HLAC RS12690
gene id: 416348:HLAC_RS12690
uniprot id: B9LTF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

416348:HLAC RS02220
gene id: 416348:HLAC_RS02220
uniprot id: B9LSY4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS02805
gene id: 416348:HLAC_RS02805
uniprot id: B9LTN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

416348:HLAC RS04145
gene id: 416348:HLAC_RS04145
uniprot id: B9LUV9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS05150
gene id: 416348:HLAC_RS05150
uniprot id: B9LMQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

416348:HLAC RS02080
gene id: 416348:HLAC_RS02080
uniprot id: B9LSV7
names: Similarity
messages: Belongs to the RutC family.

416348:HLAC RS05530
gene id: 416348:HLAC_RS05530
uniprot id: B9LMX4
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

416348:HLAC RS14675
gene id: 416348:HLAC_RS14675
uniprot id: B9LWD3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS00845
gene id: 416348:HLAC_RS00845
uniprot id: B9LRE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS07830
gene id: 416348:HLAC_RS07830
uniprot id: B9LP75
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

416348:HLAC RS01075
gene id: 416348:HLAC_RS01075
uniprot id: B9LRJ8
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04710
gene id: 416348:HLAC_RS04710
uniprot id: B9LMG4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

416348:HLAC RS12520
gene id: 416348:HLAC_RS12520
uniprot id: B9LTC4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS05970
gene id: 416348:HLAC_RS05970
uniprot id: B9LN61
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

416348:HLAC RS11800
gene id: 416348:HLAC_RS11800
uniprot id: B9LSK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

416348:HLAC RS11725
gene id: 416348:HLAC_RS11725
uniprot id: B9LSI7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

416348:HLAC RS12140
gene id: 416348:HLAC_RS12140
uniprot id: B9LSS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

416348:HLAC RS00480
gene id: 416348:HLAC_RS00480
uniprot id: B9LQV0
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

416348:HLAC RS09260
gene id: 416348:HLAC_RS09260
uniprot id: B9LQ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

416348:HLAC RS01745
gene id: 416348:HLAC_RS01745
uniprot id: B9LSB3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

416348:HLAC RS11950
gene id: 416348:HLAC_RS11950
uniprot id: B9LSN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

416348:HLAC RS10075
gene id: 416348:HLAC_RS10075
uniprot id: B9LQI3
names: Similarity
messages: Belongs to the UPF0045 family.

416348:HLAC RS04115
gene id: 416348:HLAC_RS04115
uniprot id: B9LUV3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

416348:HLAC RS01405
gene id: 416348:HLAC_RS01405
uniprot id: B9LS43
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

416348:HLAC RS12155
gene id: 416348:HLAC_RS12155
uniprot id: B9LSS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

416348:HLAC RS11195
gene id: 416348:HLAC_RS11195
uniprot id: B9LRV5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

416348:HLAC RS00020
gene id: 416348:HLAC_RS00020
uniprot id: B9LQ76
names: Similarity
messages: Belongs to the IMPACT family.

416348:HLAC RS06125
gene id: 416348:HLAC_RS06125
uniprot id: B9LN90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

416348:HLAC RS00595
gene id: 416348:HLAC_RS00595
uniprot id: B9LQX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Homodimer.

416348:HLAC RS12310
gene id: 416348:HLAC_RS12310
uniprot id: B9LT80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

416348:HLAC RS10610
gene id: 416348:HLAC_RS10610
uniprot id: B9LR56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

416348:HLAC RS14585
gene id: 416348:HLAC_RS14585
uniprot id: B9LWB8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

416348:HLAC RS01100
gene id: 416348:HLAC_RS01100
uniprot id: B9LRK3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

416348:HLAC RS05080
gene id: 416348:HLAC_RS05080
uniprot id: B9LMN6
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11530
gene id: 416348:HLAC_RS11530
uniprot id: B9LS22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

416348:HLAC RS13415
gene id: 416348:HLAC_RS13415
uniprot id: B9LU79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

416348:HLAC RS01725
gene id: 416348:HLAC_RS01725
uniprot id: B9LSA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

416348:HLAC RS06320
gene id: 416348:HLAC_RS06320
uniprot id: B9LNC8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS12275
gene id: 416348:HLAC_RS12275
uniprot id: B9LT73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

416348:HLAC RS10180
gene id: 416348:HLAC_RS10180
uniprot id: B9LQK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

416348:HLAC RS00080
gene id: 416348:HLAC_RS00080
uniprot id: B9LQM2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

416348:HLAC RS06070
gene id: 416348:HLAC_RS06070
uniprot id: B9LN81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS06890
gene id: 416348:HLAC_RS06890
uniprot id: B9LNN8
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

416348:HLAC RS13115
gene id: 416348:HLAC_RS13115
uniprot id: B9LU19
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

416348:HLAC RS09765
gene id: 416348:HLAC_RS09765
uniprot id: B9LQC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

416348:HLAC RS05815
gene id: 416348:HLAC_RS05815
uniprot id: B9LN30
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

416348:HLAC RS02475
gene id: 416348:HLAC_RS02475
uniprot id: B9LT35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

416348:HLAC RS02410
gene id: 416348:HLAC_RS02410
uniprot id: B9LT22
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS00300
gene id: 416348:HLAC_RS00300
uniprot id: B9LQR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

416348:HLAC RS06655
gene id: 416348:HLAC_RS06655
uniprot id: B9LNJ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS10880
gene id: 416348:HLAC_RS10880
uniprot id: B9LRB5
names: Subcellular Location Annotation
messages: Cell membrane

416348:HLAC RS04270
gene id: 416348:HLAC_RS04270
uniprot id: B9LUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

416348:HLAC RS06075
gene id: 416348:HLAC_RS06075
uniprot id: B9LN82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS05395
gene id: 416348:HLAC_RS05395
uniprot id: B9LMU8
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS13420
gene id: 416348:HLAC_RS13420
uniprot id: B9LU80
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

416348:HLAC RS09505
gene id: 416348:HLAC_RS09505
uniprot id: B9LQ52
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

416348:HLAC RS02345
gene id: 416348:HLAC_RS02345
uniprot id: B9LT09
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS12960
gene id: 416348:HLAC_RS12960
uniprot id: B9LTY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

416348:HLAC RS03130
gene id: 416348:HLAC_RS03130
uniprot id: B9LTU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS12160
gene id: 416348:HLAC_RS12160
uniprot id: B9LSS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

416348:HLAC RS13250
gene id: 416348:HLAC_RS13250
uniprot id: B9LU46
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04635
gene id: 416348:HLAC_RS04635
uniprot id: B9LME9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

416348:HLAC RS04300
gene id: 416348:HLAC_RS04300
uniprot id: B9LUZ0
names: Similarity
messages: Belongs to the UPF0212 family.

416348:HLAC RS04135
gene id: 416348:HLAC_RS04135
uniprot id: B9LUV7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

416348:HLAC RS02255
gene id: 416348:HLAC_RS02255
uniprot id: B9LSZ1
names: Similarity
messages: Belongs to the peptidase S49 family.

416348:HLAC RS12655
gene id: 416348:HLAC_RS12655
uniprot id: B9LTF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

416348:HLAC RS07880
gene id: 416348:HLAC_RS07880
uniprot id: B9LP86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

416348:HLAC RS04435
gene id: 416348:HLAC_RS04435
uniprot id: B9LV18
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS09700
gene id: 416348:HLAC_RS09700
uniprot id: B9LQA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

416348:HLAC RS02375
gene id: 416348:HLAC_RS02375
uniprot id: B9LT16
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS01135
gene id: 416348:HLAC_RS01135
uniprot id: B9LRL0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04700
gene id: 416348:HLAC_RS04700
uniprot id: B9LMG2
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.

416348:HLAC RS03360
gene id: 416348:HLAC_RS03360
uniprot id: B9LUC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS06535
gene id: 416348:HLAC_RS06535
uniprot id: B9LNH3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS01855
gene id: 416348:HLAC_RS01855
uniprot id: B9LSD3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

416348:HLAC RS06360
gene id: 416348:HLAC_RS06360
uniprot id: B9LND8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

416348:HLAC RS12410
gene id: 416348:HLAC_RS12410
uniprot id: B9LTA2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

416348:HLAC RS08955
gene id: 416348:HLAC_RS08955
uniprot id: B9LPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS05880
gene id: 416348:HLAC_RS05880
uniprot id: B9LN43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

416348:HLAC RS02195
gene id: 416348:HLAC_RS02195
uniprot id: B9LSX9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

416348:HLAC RS06120
gene id: 416348:HLAC_RS06120
uniprot id: B9LN89
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS08450
gene id: 416348:HLAC_RS08450
uniprot id: B9LPJ6
names: Similarity
messages: Belongs to the UPF0111 family.

416348:HLAC RS06855
gene id: 416348:HLAC_RS06855
uniprot id: B9LNN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

416348:HLAC RS02030
gene id: 416348:HLAC_RS02030
uniprot id: B9LSU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

416348:HLAC RS12585
gene id: 416348:HLAC_RS12585
uniprot id: B9LTD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

416348:HLAC RS07920
gene id: 416348:HLAC_RS07920
uniprot id: B9LP93
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS12070
gene id: 416348:HLAC_RS12070
uniprot id: B9LSQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

416348:HLAC RS17360
gene id: 416348:HLAC_RS17360
uniprot id: B9LXB9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

416348:HLAC RS11635
gene id: 416348:HLAC_RS11635
uniprot id: B9LSH0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

416348:HLAC RS09065
gene id: 416348:HLAC_RS09065
uniprot id: B9LPW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

416348:HLAC RS04640
gene id: 416348:HLAC_RS04640
uniprot id: B9LMF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

416348:HLAC RS03485
gene id: 416348:HLAC_RS03485
uniprot id: B9LUE8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

416348:HLAC RS13605
gene id: 416348:HLAC_RS13605
uniprot id: B9LUP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

416348:HLAC RS00895
gene id: 416348:HLAC_RS00895
uniprot id: B9LRF9
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

416348:HLAC RS07595
gene id: 416348:HLAC_RS07595
uniprot id: B9LP32
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

416348:HLAC RS02465
gene id: 416348:HLAC_RS02465
uniprot id: B9LT33
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

416348:HLAC RS02695
gene id: 416348:HLAC_RS02695
uniprot id: B9LTL1
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

416348:HLAC RS08845
gene id: 416348:HLAC_RS08845
uniprot id: B9LPS2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10440
gene id: 416348:HLAC_RS10440
uniprot id: B9LR22
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

416348:HLAC RS06805
gene id: 416348:HLAC_RS06805
uniprot id: B9LNM1
names: Similarity
messages: Belongs to the AOR/FOR family.

416348:HLAC RS12800
gene id: 416348:HLAC_RS12800
uniprot id: B9LTH8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

416348:HLAC RS11290
gene id: 416348:HLAC_RS11290
uniprot id: B9LRX4
names: Similarity
messages: Belongs to the asparaginase 1 family.

416348:HLAC RS06645
gene id: 416348:HLAC_RS06645
uniprot id: B9LNJ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS11170
gene id: 416348:HLAC_RS11170
uniprot id: B9LRV1
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

416348:HLAC RS04130
gene id: 416348:HLAC_RS04130
uniprot id: B9LUV6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

416348:HLAC RS00605
gene id: 416348:HLAC_RS00605
uniprot id: B9LQX3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

416348:HLAC RS02240
gene id: 416348:HLAC_RS02240
uniprot id: B9LSY8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

416348:HLAC RS02515
gene id: 416348:HLAC_RS02515
uniprot id: B9LT43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

416348:HLAC RS04945
gene id: 416348:HLAC_RS04945
uniprot id: B9LML0
names: Subcellular Location Annotation
messages: Cell membrane

416348:HLAC RS15855
gene id: 416348:HLAC_RS15855
uniprot id: B9LVR1
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

416348:HLAC RS03530
gene id: 416348:HLAC_RS03530
uniprot id: B9LUF7
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS02895
gene id: 416348:HLAC_RS02895
uniprot id: B9LTQ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS12945
gene id: 416348:HLAC_RS12945
uniprot id: B9LTY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

416348:HLAC RS01610
gene id: 416348:HLAC_RS01610
uniprot id: B9LS86
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04175
gene id: 416348:HLAC_RS04175
uniprot id: B9LUW5
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11115
gene id: 416348:HLAC_RS11115
uniprot id: B9LRT9
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

416348:HLAC RS08420
gene id: 416348:HLAC_RS08420
uniprot id: B9LPJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

416348:HLAC RS10520
gene id: 416348:HLAC_RS10520
uniprot id: B9LR39
names: Similarity
messages: Belongs to the BtpA family.

416348:HLAC RS13560
gene id: 416348:HLAC_RS13560
uniprot id: B9LUN4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

416348:HLAC RS05510
gene id: 416348:HLAC_RS05510
uniprot id: B9LMX0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

416348:HLAC RS12965
gene id: 416348:HLAC_RS12965
uniprot id: B9LTY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

416348:HLAC RS12400
gene id: 416348:HLAC_RS12400
uniprot id: B9LTA0
names: Similarity
messages: Belongs to the HypE family.

416348:HLAC RS05845
gene id: 416348:HLAC_RS05845
uniprot id: B9LN36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

416348:HLAC RS07855
gene id: 416348:HLAC_RS07855
uniprot id: B9LP80
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

416348:HLAC RS03020
gene id: 416348:HLAC_RS03020
uniprot id: B9LTS6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

416348:HLAC RS07835
gene id: 416348:HLAC_RS07835
uniprot id: B9LP76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

416348:HLAC RS08890
gene id: 416348:HLAC_RS08890
uniprot id: B9LPT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS11030
gene id: 416348:HLAC_RS11030
uniprot id: B9LRS4
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10310
gene id: 416348:HLAC_RS10310
uniprot id: B9LQZ8
names: Caution
names: Similarity
messages: Belongs to the UPF0391 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS01645
gene id: 416348:HLAC_RS01645
uniprot id: B9LS94
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

416348:HLAC RS07035
gene id: 416348:HLAC_RS07035
uniprot id: B9LNR8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

416348:HLAC RS00675
gene id: 416348:HLAC_RS00675
uniprot id: B9LQY6
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10765
gene id: 416348:HLAC_RS10765
uniprot id: B9LR89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS06675
gene id: 416348:HLAC_RS06675
uniprot id: B9LNK1
names: Similarity
messages: Belongs to the UPF0173 family.

416348:HLAC RS12985
gene id: 416348:HLAC_RS12985
uniprot id: B9LTZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS10490
gene id: 416348:HLAC_RS10490
uniprot id: B9LR32
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

416348:HLAC RS06965
gene id: 416348:HLAC_RS06965
uniprot id: B9LNQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS05030
gene id: 416348:HLAC_RS05030
uniprot id: B9LMM7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

416348:HLAC RS10280
gene id: 416348:HLAC_RS10280
uniprot id: B9LQZ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

416348:HLAC RS03015
gene id: 416348:HLAC_RS03015
uniprot id: B9LTS5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

416348:HLAC RS12920
gene id: 416348:HLAC_RS12920
uniprot id: B9LTX9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

416348:HLAC RS03350
gene id: 416348:HLAC_RS03350
uniprot id: B9LUC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS17490
gene id: 416348:HLAC_RS17490
uniprot id: B9LXE5
names: Similarity
messages: Belongs to the SELO family.

416348:HLAC RS06915
gene id: 416348:HLAC_RS06915
uniprot id: B9LNP3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS11860
gene id: 416348:HLAC_RS11860
uniprot id: B9LSL4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

416348:HLAC RS14155
gene id: 416348:HLAC_RS14155
uniprot id: B9LW33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS02680
gene id: 416348:HLAC_RS02680
uniprot id: B9LTK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS06530
gene id: 416348:HLAC_RS06530
uniprot id: B9LNH2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

416348:HLAC RS05390
gene id: 416348:HLAC_RS05390
uniprot id: B9LMU7
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS05005
gene id: 416348:HLAC_RS05005
uniprot id: B9LMM2
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

416348:HLAC RS10840
gene id: 416348:HLAC_RS10840
uniprot id: B9LRA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

416348:HLAC RS15020
gene id: 416348:HLAC_RS15020
uniprot id: B9LV81
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

416348:HLAC RS12580
gene id: 416348:HLAC_RS12580
uniprot id: B9LTD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

416348:HLAC RS12105
gene id: 416348:HLAC_RS12105
uniprot id: B9LSR5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

416348:HLAC RS10115
gene id: 416348:HLAC_RS10115
uniprot id: B9LQJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

416348:HLAC RS03500
gene id: 416348:HLAC_RS03500
uniprot id: B9LUF1
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

416348:HLAC RS12420
gene id: 416348:HLAC_RS12420
uniprot id: B9LTA4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

416348:HLAC RS02505
gene id: 416348:HLAC_RS02505
uniprot id: B9LT41
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

416348:HLAC RS03410
gene id: 416348:HLAC_RS03410
uniprot id: B9LUD3
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS09695
gene id: 416348:HLAC_RS09695
uniprot id: B9LQA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

416348:HLAC RS01290
gene id: 416348:HLAC_RS01290
uniprot id: B9LRP1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

416348:HLAC RS01150
gene id: 416348:HLAC_RS01150
uniprot id: B9LRL3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

416348:HLAC RS05215
gene id: 416348:HLAC_RS05215
uniprot id: B9LMR3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS04225
gene id: 416348:HLAC_RS04225
uniprot id: B9LUX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

416348:HLAC RS04450
gene id: 416348:HLAC_RS04450
uniprot id: B9LV21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

416348:HLAC RS01130
gene id: 416348:HLAC_RS01130
uniprot id: B9LRK9
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS14555
gene id: 416348:HLAC_RS14555
uniprot id: B9LWB0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS09035
gene id: 416348:HLAC_RS09035
uniprot id: B9LPW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

416348:HLAC RS05120
gene id: 416348:HLAC_RS05120
uniprot id: B9LMP5
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

416348:HLAC RS10325
gene id: 416348:HLAC_RS10325
uniprot id: B9LR01
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS11620
gene id: 416348:HLAC_RS11620
uniprot id: B9LSG7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

416348:HLAC RS08960
gene id: 416348:HLAC_RS08960
uniprot id: B9LPU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS10165
gene id: 416348:HLAC_RS10165
uniprot id: B9LQK1
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

416348:HLAC RS13255
gene id: 416348:HLAC_RS13255
uniprot id: B9LU47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

416348:HLAC RS03345
gene id: 416348:HLAC_RS03345
uniprot id: B9LUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS02980
gene id: 416348:HLAC_RS02980
uniprot id: B9LTR8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS09390
gene id: 416348:HLAC_RS09390
uniprot id: B9LQ29
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS05910
gene id: 416348:HLAC_RS05910
uniprot id: B9LN49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

416348:HLAC RS02140
gene id: 416348:HLAC_RS02140
uniprot id: B9LSW9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

416348:HLAC RS01830
gene id: 416348:HLAC_RS01830
uniprot id: B9LSC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

416348:HLAC RS02095
gene id: 416348:HLAC_RS02095
uniprot id: B9LSW0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

416348:HLAC RS10720
gene id: 416348:HLAC_RS10720
uniprot id: B9LR80
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

416348:HLAC RS10650
gene id: 416348:HLAC_RS10650
uniprot id: B9LR64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

416348:HLAC RS10860
gene id: 416348:HLAC_RS10860
uniprot id: B9LRB1
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

416348:HLAC RS08030
gene id: 416348:HLAC_RS08030
uniprot id: B9LPB4
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS05045
gene id: 416348:HLAC_RS05045
uniprot id: B9LMN0
names: Subcellular Location Annotation
messages: Cytoplasm

416348:HLAC RS00185
gene id: 416348:HLAC_RS00185
uniprot id: B9LQP1
names: Similarity
messages: Belongs to the 2Fe2S plant-type ferredoxin family.

416348:HLAC RS12055
gene id: 416348:HLAC_RS12055
uniprot id: B9LSQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

416348:HLAC RS10185
gene id: 416348:HLAC_RS10185
uniprot id: B9LQK5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

416348:HLAC RS14180
gene id: 416348:HLAC_RS14180
uniprot id: B9LW38
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.
messages: Cleaves o-nitrophenyl-beta-D-galactopyranoside (ONPG) in vitro.
messages: Requires 4 M NaCl or KCl for maximal activity.

416348:HLAC RS17650
gene id: 416348:HLAC_RS17650
uniprot id: B9LSD1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

416348:HLAC RS03665
gene id: 416348:HLAC_RS03665
uniprot id: B9LUI3
names: Similarity
messages: Belongs to the MCM family.

416348:HLAC RS04995
gene id: 416348:HLAC_RS04995
uniprot id: B9LMM0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

416348:HLAC RS12345
gene id: 416348:HLAC_RS12345
uniprot id: B9LT88
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

416348:HLAC RS09160
gene id: 416348:HLAC_RS09160
uniprot id: B9LPY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

416348:HLAC RS07225
gene id: 416348:HLAC_RS07225
uniprot id: B9LNW0
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

416348:HLAC RS13095
gene id: 416348:HLAC_RS13095
uniprot id: B9LU15
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

416348:HLAC RS00440
gene id: 416348:HLAC_RS00440
uniprot id: B9LQU0
names: Similarity
messages: Belongs to the Ahb/Nir family.

416348:HLAC RS10965
gene id: 416348:HLAC_RS10965
uniprot id: B9LRR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

416348:HLAC RS05670
gene id: 416348:HLAC_RS05670
uniprot id: B9LN01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS10385
gene id: 416348:HLAC_RS10385
uniprot id: B9LR13
names: Caution
names: Similarity
messages: Belongs to the UPF0391 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS05980
gene id: 416348:HLAC_RS05980
uniprot id: B9LN63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

416348:HLAC RS03075
gene id: 416348:HLAC_RS03075
uniprot id: B9LTT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

416348:HLAC RS12095
gene id: 416348:HLAC_RS12095
uniprot id: B9LSR3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS12075
gene id: 416348:HLAC_RS12075
uniprot id: B9LSQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

416348:HLAC RS06415
gene id: 416348:HLAC_RS06415
uniprot id: B9LNE9
names: Similarity
messages: Belongs to the GARS family.

416348:HLAC RS08460
gene id: 416348:HLAC_RS08460
uniprot id: B9LPJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

416348:HLAC RS12060
gene id: 416348:HLAC_RS12060
uniprot id: B9LSQ6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

416348:HLAC RS14420
gene id: 416348:HLAC_RS14420
uniprot id: B9LW83
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS08130
gene id: 416348:HLAC_RS08130
uniprot id: B9LPD4
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04985
gene id: 416348:HLAC_RS04985
uniprot id: B9LML8
names: Similarity
messages: Belongs to the eIF-2-alpha family.

416348:HLAC RS06575
gene id: 416348:HLAC_RS06575
uniprot id: B9LNI1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

416348:HLAC RS03385
gene id: 416348:HLAC_RS03385
uniprot id: B9LUC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

416348:HLAC RS10975
gene id: 416348:HLAC_RS10975
uniprot id: B9LRR3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

416348:HLAC RS11035
gene id: 416348:HLAC_RS11035
uniprot id: B9LRS5
names: Similarity
messages: Belongs to the peptidase C56 family.

416348:HLAC RS04740
gene id: 416348:HLAC_RS04740
uniprot id: B9LMH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

416348:HLAC RS10135
gene id: 416348:HLAC_RS10135
uniprot id: B9LQJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

416348:HLAC RS06395
gene id: 416348:HLAC_RS06395
uniprot id: B9LNE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

416348:HLAC RS06305
gene id: 416348:HLAC_RS06305
uniprot id: B9LNC5
names: Similarity
messages: Belongs to the TrpC family.

416348:HLAC RS00400
gene id: 416348:HLAC_RS00400
uniprot id: B9LQT2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS11270
gene id: 416348:HLAC_RS11270
uniprot id: B9LRX0
names: Subunit
messages: Homotetramer.

416348:HLAC RS11895
gene id: 416348:HLAC_RS11895
uniprot id: B9LSM2
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

416348:HLAC RS01720
gene id: 416348:HLAC_RS01720
uniprot id: B9LSA8
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

416348:HLAC RS09385
gene id: 416348:HLAC_RS09385
uniprot id: B9LQ28
names: Similarity
messages: Belongs to the thymidylate kinase family.

416348:HLAC RS04510
gene id: 416348:HLAC_RS04510
uniprot id: B9LMC2
names: Similarity
messages: Belongs to the glutamate synthase family.

416348:HLAC RS00530
gene id: 416348:HLAC_RS00530
uniprot id: B9LQW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

416348:HLAC RS04910
gene id: 416348:HLAC_RS04910
uniprot id: B9LMK3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

416348:HLAC RS12515
gene id: 416348:HLAC_RS12515
uniprot id: B9LTC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS03065
gene id: 416348:HLAC_RS03065
uniprot id: B9LTT6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

416348:HLAC RS05195
gene id: 416348:HLAC_RS05195
uniprot id: B9LMQ9
names: Similarity
messages: Belongs to the AOR/FOR family.

416348:HLAC RS09760
gene id: 416348:HLAC_RS09760
uniprot id: B9LQC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

416348:HLAC RS01750
gene id: 416348:HLAC_RS01750
uniprot id: B9LSB4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS10780
gene id: 416348:HLAC_RS10780
uniprot id: B9LR93
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS06195
gene id: 416348:HLAC_RS06195
uniprot id: B9LNA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

416348:HLAC RS02810
gene id: 416348:HLAC_RS02810
uniprot id: B9LTN4
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

416348:HLAC RS08280
gene id: 416348:HLAC_RS08280
uniprot id: B9LPG2
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS07285
gene id: 416348:HLAC_RS07285
uniprot id: B9LNX2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

416348:HLAC RS12940
gene id: 416348:HLAC_RS12940
uniprot id: B9LTY2
names: Similarity
messages: Belongs to the RutC family.

416348:HLAC RS11005
gene id: 416348:HLAC_RS11005
uniprot id: B9LRR9
names: Similarity
messages: Belongs to the PDCD5 family.

416348:HLAC RS13005
gene id: 416348:HLAC_RS13005
uniprot id: B9LTZ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS07350
gene id: 416348:HLAC_RS07350
uniprot id: B9LNY5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

416348:HLAC RS02715
gene id: 416348:HLAC_RS02715
uniprot id: B9LTL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

416348:HLAC RS02700
gene id: 416348:HLAC_RS02700
uniprot id: B9LTL2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

416348:HLAC RS03915
gene id: 416348:HLAC_RS03915
uniprot id: B9LUR3
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04155
gene id: 416348:HLAC_RS04155
uniprot id: B9LUW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS10605
gene id: 416348:HLAC_RS10605
uniprot id: B9LR55
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

416348:HLAC RS08315
gene id: 416348:HLAC_RS08315
uniprot id: B9LPG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

416348:HLAC RS04110
gene id: 416348:HLAC_RS04110
uniprot id: B9LUV2
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

416348:HLAC RS14210
gene id: 416348:HLAC_RS14210
uniprot id: B9LW43
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

416348:HLAC RS08915
gene id: 416348:HLAC_RS08915
uniprot id: B9LPT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

416348:HLAC RS10740
gene id: 416348:HLAC_RS10740
uniprot id: B9LR84
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

416348:HLAC RS12455
gene id: 416348:HLAC_RS12455
uniprot id: B9LTB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

416348:HLAC RS03970
gene id: 416348:HLAC_RS03970
uniprot id: B9LUS4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

416348:HLAC RS00315
gene id: 416348:HLAC_RS00315
uniprot id: B9LQR5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS12340
gene id: 416348:HLAC_RS12340
uniprot id: B9LT87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS11585
gene id: 416348:HLAC_RS11585
uniprot id: B9LSG0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS01210
gene id: 416348:HLAC_RS01210
uniprot id: B9LRM5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS12150
gene id: 416348:HLAC_RS12150
uniprot id: B9LSS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

416348:HLAC RS13505
gene id: 416348:HLAC_RS13505
uniprot id: B9LUM3
names: Similarity
messages: Belongs to the threonine synthase family.

416348:HLAC RS13310
gene id: 416348:HLAC_RS13310
uniprot id: B9LU58
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS13400
gene id: 416348:HLAC_RS13400
uniprot id: B9LU76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

416348:HLAC RS15060
gene id: 416348:HLAC_RS15060
uniprot id: B9LV88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

416348:HLAC RS06090
gene id: 416348:HLAC_RS06090
uniprot id: B9LN84
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS13465
gene id: 416348:HLAC_RS13465
uniprot id: B9LU88
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04045
gene id: 416348:HLAC_RS04045
uniprot id: B9LUU0
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

416348:HLAC RS04590
gene id: 416348:HLAC_RS04590
uniprot id: B9LME0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS14025
gene id: 416348:HLAC_RS14025
uniprot id: B9LW07
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

416348:HLAC RS01200
gene id: 416348:HLAC_RS01200
uniprot id: B9LRM3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

416348:HLAC RS17095
gene id: 416348:HLAC_RS17095
uniprot id: B9LX51
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS12085
gene id: 416348:HLAC_RS12085
uniprot id: B9LSR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

416348:HLAC RS12100
gene id: 416348:HLAC_RS12100
uniprot id: B9LSR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

416348:HLAC RS02280
gene id: 416348:HLAC_RS02280
uniprot id: B9LSZ6
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

416348:HLAC RS01170
gene id: 416348:HLAC_RS01170
uniprot id: B9LRL7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS16365
gene id: 416348:HLAC_RS16365
uniprot id: B9LWP6
names: Caution
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS02290
gene id: 416348:HLAC_RS02290
uniprot id: B9LSZ8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS00340
gene id: 416348:HLAC_RS00340
uniprot id: B9LQS0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS09230
gene id: 416348:HLAC_RS09230
uniprot id: B9LPZ7
names: Similarity
messages: Belongs to the UPF0200 family.

416348:HLAC RS07150
gene id: 416348:HLAC_RS07150
uniprot id: B9LNU2
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

416348:HLAC RS09470
gene id: 416348:HLAC_RS09470
uniprot id: B9LQ45
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS02155
gene id: 416348:HLAC_RS02155
uniprot id: B9LSX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

416348:HLAC RS13510
gene id: 416348:HLAC_RS13510
uniprot id: B9LUM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

416348:HLAC RS01620
gene id: 416348:HLAC_RS01620
uniprot id: B9LS90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

416348:HLAC RS11890
gene id: 416348:HLAC_RS11890
uniprot id: B9LSM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

416348:HLAC RS13380
gene id: 416348:HLAC_RS13380
uniprot id: B9LU72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS00885
gene id: 416348:HLAC_RS00885
uniprot id: B9LRF7
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

416348:HLAC RS11845
gene id: 416348:HLAC_RS11845
uniprot id: B9LSL1
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS12955
gene id: 416348:HLAC_RS12955
uniprot id: B9LTY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

416348:HLAC RS06920
gene id: 416348:HLAC_RS06920
uniprot id: B9LNP4
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

416348:HLAC RS03535
gene id: 416348:HLAC_RS03535
uniprot id: B9LUF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

416348:HLAC RS05775
gene id: 416348:HLAC_RS05775
uniprot id: B9LN22
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

416348:HLAC RS05290
gene id: 416348:HLAC_RS05290
uniprot id: B9LMS7
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS17290
gene id: 416348:HLAC_RS17290
uniprot id: B9LX94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

416348:HLAC RS06580
gene id: 416348:HLAC_RS06580
uniprot id: B9LNI2
names: Similarity
messages: Belongs to the peptidase M24B family.

416348:HLAC RS04455
gene id: 416348:HLAC_RS04455
uniprot id: B9LV22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

416348:HLAC RS01495
gene id: 416348:HLAC_RS01495
uniprot id: B9LS63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

416348:HLAC RS04035
gene id: 416348:HLAC_RS04035
uniprot id: B9LUT7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

416348:HLAC RS11465
gene id: 416348:HLAC_RS11465
uniprot id: B9LS09
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

416348:HLAC RS02485
gene id: 416348:HLAC_RS02485
uniprot id: B9LT37
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS09680
gene id: 416348:HLAC_RS09680
uniprot id: B9LQA4
names: Subcellular Location Annotation
messages: Cytoplasm

416348:HLAC RS09735
gene id: 416348:HLAC_RS09735
uniprot id: B9LQB5
names: Similarity
messages: Belongs to the AAA ATPase family.

416348:HLAC RS07960
gene id: 416348:HLAC_RS07960
uniprot id: B9LPA0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS09100
gene id: 416348:HLAC_RS09100
uniprot id: B9LPX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

416348:HLAC RS12125
gene id: 416348:HLAC_RS12125
uniprot id: B9LSR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

416348:HLAC RS01375
gene id: 416348:HLAC_RS01375
uniprot id: B9LS37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

416348:HLAC RS07925
gene id: 416348:HLAC_RS07925
uniprot id: B9LP94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

416348:HLAC RS01525
gene id: 416348:HLAC_RS01525
uniprot id: B9LS69
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS12760
gene id: 416348:HLAC_RS12760
uniprot id: B9LTH1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

416348:HLAC RS07475
gene id: 416348:HLAC_RS07475
uniprot id: B9LP11
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

416348:HLAC RS14415
gene id: 416348:HLAC_RS14415
uniprot id: B9LW82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS09860
gene id: 416348:HLAC_RS09860
uniprot id: B9LQE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

416348:HLAC RS13120
gene id: 416348:HLAC_RS13120
uniprot id: B9LU20
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10685
gene id: 416348:HLAC_RS10685
uniprot id: B9LR71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS03590
gene id: 416348:HLAC_RS03590
uniprot id: B9LUG9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

416348:HLAC RS02065
gene id: 416348:HLAC_RS02065
uniprot id: B9LSV4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

416348:HLAC RS07315
gene id: 416348:HLAC_RS07315
uniprot id: B9LNX7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

416348:HLAC RS04875
gene id: 416348:HLAC_RS04875
uniprot id: B9LMJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

416348:HLAC RS11310
gene id: 416348:HLAC_RS11310
uniprot id: B9LRX8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

416348:HLAC RS12110
gene id: 416348:HLAC_RS12110
uniprot id: B9LSR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

416348:HLAC RS07585
gene id: 416348:HLAC_RS07585
uniprot id: B9LP30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

416348:HLAC RS01520
gene id: 416348:HLAC_RS01520
uniprot id: B9LS68
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

416348:HLAC RS06190
gene id: 416348:HLAC_RS06190
uniprot id: B9LNA3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

416348:HLAC RS01390
gene id: 416348:HLAC_RS01390
uniprot id: B9LS40
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

416348:HLAC RS06130
gene id: 416348:HLAC_RS06130
uniprot id: B9LN91
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

416348:HLAC RS13170
gene id: 416348:HLAC_RS13170
uniprot id: B9LU30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

416348:HLAC RS15445
gene id: 416348:HLAC_RS15445
uniprot id: B9LVH7
names: Similarity
messages: Belongs to the UPF0175 family.

416348:HLAC RS13410
gene id: 416348:HLAC_RS13410
uniprot id: B9LU78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

416348:HLAC RS13545
gene id: 416348:HLAC_RS13545
uniprot id: B9LUN1
names: Similarity
messages: Belongs to the cytochrome P450 family.

416348:HLAC RS00065
gene id: 416348:HLAC_RS00065
uniprot id: B9LQ87
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

416348:HLAC RS05330
gene id: 416348:HLAC_RS05330
uniprot id: B9LMT5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

416348:HLAC RS11555
gene id: 416348:HLAC_RS11555
uniprot id: B9LSF4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

416348:HLAC RS03045
gene id: 416348:HLAC_RS03045
uniprot id: B9LTT2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11905
gene id: 416348:HLAC_RS11905
uniprot id: B9LSM4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

416348:HLAC RS02670
gene id: 416348:HLAC_RS02670
uniprot id: B9LTK6
names: Subcellular Location Annotation
messages: Cytoplasm

416348:HLAC RS12370
gene id: 416348:HLAC_RS12370
uniprot id: B9LT94
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

416348:HLAC RS02535
gene id: 416348:HLAC_RS02535
uniprot id: B9LT47
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

416348:HLAC RS07875
gene id: 416348:HLAC_RS07875
uniprot id: B9LP84
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

416348:HLAC RS11550
gene id: 416348:HLAC_RS11550
uniprot id: B9LSF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

416348:HLAC RS06315
gene id: 416348:HLAC_RS06315
uniprot id: B9LNC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

416348:HLAC RS13365
gene id: 416348:HLAC_RS13365
uniprot id: B9LU69
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS03355
gene id: 416348:HLAC_RS03355
uniprot id: B9LUC2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS13065
gene id: 416348:HLAC_RS13065
uniprot id: B9LU08
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

416348:HLAC RS00430
gene id: 416348:HLAC_RS00430
uniprot id: B9LQT8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

416348:HLAC RS11350
gene id: 416348:HLAC_RS11350
uniprot id: B9LRY6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

416348:HLAC RS16200
gene id: 416348:HLAC_RS16200
uniprot id: B9LWK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

416348:HLAC RS02940
gene id: 416348:HLAC_RS02940
uniprot id: B9LTR0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

416348:HLAC RS02835
gene id: 416348:HLAC_RS02835
uniprot id: B9LTN9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

416348:HLAC RS01350
gene id: 416348:HLAC_RS01350
uniprot id: B9LS32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

416348:HLAC RS09325
gene id: 416348:HLAC_RS09325
uniprot id: B9LQ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

416348:HLAC RS03565
gene id: 416348:HLAC_RS03565
uniprot id: B9LUG4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

416348:HLAC RS01660
gene id: 416348:HLAC_RS01660
uniprot id: B9LS95
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

416348:HLAC RS05755
gene id: 416348:HLAC_RS05755
uniprot id: B9LN18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS13570
gene id: 416348:HLAC_RS13570
uniprot id: B9LUN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane

416348:HLAC RS16345
gene id: 416348:HLAC_RS16345
uniprot id: B9LWP2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS15055
gene id: 416348:HLAC_RS15055
uniprot id: B9LV87
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS06615
gene id: 416348:HLAC_RS06615
uniprot id: B9LNI9
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

416348:HLAC RS07170
gene id: 416348:HLAC_RS07170
uniprot id: B9LNU7
names: Similarity
messages: Belongs to the manganese catalase family.

416348:HLAC RS00760
gene id: 416348:HLAC_RS00760
uniprot id: B9LRD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

416348:HLAC RS13200
gene id: 416348:HLAC_RS13200
uniprot id: B9LU37
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

416348:HLAC RS00790
gene id: 416348:HLAC_RS00790
uniprot id: B9LRD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

416348:HLAC RS11790
gene id: 416348:HLAC_RS11790
uniprot id: B9LSK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

416348:HLAC RS00865
gene id: 416348:HLAC_RS00865
uniprot id: B9LRF3
names: Similarity
messages: Belongs to the DtxR/MntR family.

416348:HLAC RS09130
gene id: 416348:HLAC_RS09130
uniprot id: B9LPX8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

416348:HLAC RS02050
gene id: 416348:HLAC_RS02050
uniprot id: B9LSV1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

416348:HLAC RS09645
gene id: 416348:HLAC_RS09645
uniprot id: B9LQ97
names: Similarity
messages: Belongs to the TrpF family.

416348:HLAC RS05555
gene id: 416348:HLAC_RS05555
uniprot id: B9LMX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

416348:HLAC RS04065
gene id: 416348:HLAC_RS04065
uniprot id: B9LUU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

416348:HLAC RS01385
gene id: 416348:HLAC_RS01385
uniprot id: B9LS39
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

416348:HLAC RS09420
gene id: 416348:HLAC_RS09420
uniprot id: B9LQ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

416348:HLAC RS16170
gene id: 416348:HLAC_RS16170
uniprot id: B9LWK2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

416348:HLAC RS11025
gene id: 416348:HLAC_RS11025
uniprot id: B9LRS3
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03990
gene id: 416348:HLAC_RS03990
uniprot id: B9LUS8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

416348:HLAC RS00320
gene id: 416348:HLAC_RS00320
uniprot id: B9LQR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

416348:HLAC RS13025
gene id: 416348:HLAC_RS13025
uniprot id: B9LU00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P(II) protein family.
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

416348:HLAC RS12145
gene id: 416348:HLAC_RS12145
uniprot id: B9LSS3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

416348:HLAC RS08920
gene id: 416348:HLAC_RS08920
uniprot id: B9LPU0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04915
gene id: 416348:HLAC_RS04915
uniprot id: B9LMK4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

416348:HLAC RS16485
gene id: 416348:HLAC_RS16485
uniprot id: B9LWS1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

416348:HLAC RS01145
gene id: 416348:HLAC_RS01145
uniprot id: B9LRL2
names: Similarity
messages: Belongs to the UPF0284 family.

416348:HLAC RS10065
gene id: 416348:HLAC_RS10065
uniprot id: B9LQI1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

416348:HLAC RS12130
gene id: 416348:HLAC_RS12130
uniprot id: B9LSS0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

416348:HLAC RS12935
gene id: 416348:HLAC_RS12935
uniprot id: B9LTY1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

416348:HLAC RS04205
gene id: 416348:HLAC_RS04205
uniprot id: B9LUX1
names: Similarity
messages: Belongs to the SDO1/SBDS family.

416348:HLAC RS14755
gene id: 416348:HLAC_RS14755
uniprot id: B9LV27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

416348:HLAC RS10695
gene id: 416348:HLAC_RS10695
uniprot id: B9LR73
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS00930
gene id: 416348:HLAC_RS00930
uniprot id: B9LRG7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

416348:HLAC RS09540
gene id: 416348:HLAC_RS09540
uniprot id: B9LQ59
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

416348:HLAC RS11280
gene id: 416348:HLAC_RS11280
uniprot id: B9LRX2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

416348:HLAC RS02500
gene id: 416348:HLAC_RS02500
uniprot id: B9LT40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

416348:HLAC RS12350
gene id: 416348:HLAC_RS12350
uniprot id: B9LT89
names: Similarity
messages: Belongs to the glycosyl hydrolase 68 family.

416348:HLAC RS11100
gene id: 416348:HLAC_RS11100
uniprot id: B9LRT7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

416348:HLAC RS05940
gene id: 416348:HLAC_RS05940
uniprot id: B9LN55
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS04690
gene id: 416348:HLAC_RS04690
uniprot id: B9LMG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

416348:HLAC RS06660
gene id: 416348:HLAC_RS06660
uniprot id: B9LNJ8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

416348:HLAC RS14950
gene id: 416348:HLAC_RS14950
uniprot id: B9LV67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS03135
gene id: 416348:HLAC_RS03135
uniprot id: B9LTU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS09195
gene id: 416348:HLAC_RS09195
uniprot id: B9LPZ0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

416348:HLAC RS06515
gene id: 416348:HLAC_RS06515
uniprot id: B9LNG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

416348:HLAC RS02590
gene id: 416348:HLAC_RS02590
uniprot id: B9LTI9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

416348:HLAC RS07615
gene id: 416348:HLAC_RS07615
uniprot id: B9LP36
names: Similarity
messages: Belongs to the TPP enzyme family.

416348:HLAC RS17175
gene id: 416348:HLAC_RS17175
uniprot id: B9LX68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

416348:HLAC RS14745
gene id: 416348:HLAC_RS14745
uniprot id: B9LWE8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

416348:HLAC RS15915
gene id: 416348:HLAC_RS15915
uniprot id: B9LVS7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

416348:HLAC RS10285
gene id: 416348:HLAC_RS10285
uniprot id: B9LQZ2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS09200
gene id: 416348:HLAC_RS09200
uniprot id: B9LPZ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

416348:HLAC RS01450
gene id: 416348:HLAC_RS01450
uniprot id: B9LS53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

416348:HLAC RS10825
gene id: 416348:HLAC_RS10825
uniprot id: B9LRA2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

416348:HLAC RS10735
gene id: 416348:HLAC_RS10735
uniprot id: B9LR83
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

416348:HLAC RS04465
gene id: 416348:HLAC_RS04465
uniprot id: B9LV24
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10330
gene id: 416348:HLAC_RS10330
uniprot id: B9LR02
names: Similarity
messages: Belongs to the SUI1 family.

416348:HLAC RS10595
gene id: 416348:HLAC_RS10595
uniprot id: B9LR53
names: Similarity
messages: Belongs to the Ahb/Nir family.

416348:HLAC RS03375
gene id: 416348:HLAC_RS03375
uniprot id: B9LUC6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

416348:HLAC RS00990
gene id: 416348:HLAC_RS00990
uniprot id: B9LRI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

416348:HLAC RS02210
gene id: 416348:HLAC_RS02210
uniprot id: B9LSY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

416348:HLAC RS12080
gene id: 416348:HLAC_RS12080
uniprot id: B9LSR0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

416348:HLAC RS11485
gene id: 416348:HLAC_RS11485
uniprot id: B9LS13
names: Similarity
messages: Belongs to the PEPCase type 1 family.

416348:HLAC RS02130
gene id: 416348:HLAC_RS02130
uniprot id: B9LSW7
names: Subunit
messages: Homodimer.

416348:HLAC RS14410
gene id: 416348:HLAC_RS14410
uniprot id: B9LW81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS09955
gene id: 416348:HLAC_RS09955
uniprot id: B9LQF9
names: Similarity
messages: Belongs to the Nth/MutY family.

416348:HLAC RS04095
gene id: 416348:HLAC_RS04095
uniprot id: B9LUU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

416348:HLAC RS02975
gene id: 416348:HLAC_RS02975
uniprot id: B9LTR7
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS07145
gene id: 416348:HLAC_RS07145
uniprot id: B9LNU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

416348:HLAC RS09450
gene id: 416348:HLAC_RS09450
uniprot id: B9LQ41
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS00015
gene id: 416348:HLAC_RS00015
uniprot id: B9LQ75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

416348:HLAC RS13485
gene id: 416348:HLAC_RS13485
uniprot id: B9LU92
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

416348:HLAC RS00800
gene id: 416348:HLAC_RS00800
uniprot id: B9LRE0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS01615
gene id: 416348:HLAC_RS01615
uniprot id: B9LS88
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

416348:HLAC RS04150
gene id: 416348:HLAC_RS04150
uniprot id: B9LUW0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS12875
gene id: 416348:HLAC_RS12875
uniprot id: B9LTX1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

416348:HLAC RS10415
gene id: 416348:HLAC_RS10415
uniprot id: B9LR17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

416348:HLAC RS12490
gene id: 416348:HLAC_RS12490
uniprot id: B9LTB8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

416348:HLAC RS09740
gene id: 416348:HLAC_RS09740
uniprot id: B9LQB6
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

416348:HLAC RS06225
gene id: 416348:HLAC_RS06225
uniprot id: B9LNB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

416348:HLAC RS00540
gene id: 416348:HLAC_RS00540
uniprot id: B9LQW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

416348:HLAC RS11440
gene id: 416348:HLAC_RS11440
uniprot id: B9LS04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

416348:HLAC RS13520
gene id: 416348:HLAC_RS13520
uniprot id: B9LUM6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

416348:HLAC RS02340
gene id: 416348:HLAC_RS02340
uniprot id: B9LT08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

416348:HLAC RS02015
gene id: 416348:HLAC_RS02015
uniprot id: B9LSU5
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS13340
gene id: 416348:HLAC_RS13340
uniprot id: B9LU64
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS10000
gene id: 416348:HLAC_RS10000
uniprot id: B9LQG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

416348:HLAC RS12500
gene id: 416348:HLAC_RS12500
uniprot id: B9LTC0
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

416348:HLAC RS13430
gene id: 416348:HLAC_RS13430
uniprot id: B9LU81
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

416348:HLAC RS07245
gene id: 416348:HLAC_RS07245
uniprot id: B9LNW4
names: Similarity
messages: Belongs to the AOR/FOR family.

416348:HLAC RS05130
gene id: 416348:HLAC_RS05130
uniprot id: B9LMP7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

416348:HLAC RS11660
gene id: 416348:HLAC_RS11660
uniprot id: B9LSH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

416348:HLAC RS03890
gene id: 416348:HLAC_RS03890
uniprot id: B9LUQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

416348:HLAC RS02750
gene id: 416348:HLAC_RS02750
uniprot id: B9LTM2
names: Similarity
messages: Belongs to the cytochrome P450 family.

416348:HLAC RS09660
gene id: 416348:HLAC_RS09660
uniprot id: B9LQA0
names: Similarity
messages: Belongs to the MoaB/Mog family.

416348:HLAC RS03495
gene id: 416348:HLAC_RS03495
uniprot id: B9LUF0
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

416348:HLAC RS01160
gene id: 416348:HLAC_RS01160
uniprot id: B9LRL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

416348:HLAC RS14870
gene id: 416348:HLAC_RS14870
uniprot id: B9LV51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS08655
gene id: 416348:HLAC_RS08655
uniprot id: B9LPN7
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

416348:HLAC RS04360
gene id: 416348:HLAC_RS04360
uniprot id: B9LV02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

416348:HLAC RS07080
gene id: 416348:HLAC_RS07080
uniprot id: B9LNS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS09785
gene id: 416348:HLAC_RS09785
uniprot id: B9LQC5
names: Function
messages: Part of a potassium transport system.

416348:HLAC RS06510
gene id: 416348:HLAC_RS06510
uniprot id: B9LNG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

416348:HLAC RS10425
gene id: 416348:HLAC_RS10425
uniprot id: B9LR19
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS08255
gene id: 416348:HLAC_RS08255
uniprot id: B9LPF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

416348:HLAC RS04330
gene id: 416348:HLAC_RS04330
uniprot id: B9LUZ6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

416348:HLAC RS09075
gene id: 416348:HLAC_RS09075
uniprot id: B9LPW7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

416348:HLAC RS09170
gene id: 416348:HLAC_RS09170
uniprot id: B9LPY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

416348:HLAC RS05535
gene id: 416348:HLAC_RS05535
uniprot id: B9LMX5
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

416348:HLAC RS15745
gene id: 416348:HLAC_RS15745
uniprot id: B9LVP1
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS08220
gene id: 416348:HLAC_RS08220
uniprot id: B9LPF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

416348:HLAC RS07970
gene id: 416348:HLAC_RS07970
uniprot id: B9LPA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
messages: Homotetramer.

416348:HLAC RS01910
gene id: 416348:HLAC_RS01910
uniprot id: B9LSE4
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

416348:HLAC RS01270
gene id: 416348:HLAC_RS01270
uniprot id: B9LRN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

416348:HLAC RS05450
gene id: 416348:HLAC_RS05450
uniprot id: B9LMV9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

416348:HLAC RS05680
gene id: 416348:HLAC_RS05680
uniprot id: B9LN03
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS02540
gene id: 416348:HLAC_RS02540
uniprot id: B9LT48
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

416348:HLAC RS06390
gene id: 416348:HLAC_RS06390
uniprot id: B9LNE4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

416348:HLAC RS14230
gene id: 416348:HLAC_RS14230
uniprot id: B9LW48
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

416348:HLAC RS08340
gene id: 416348:HLAC_RS08340
uniprot id: B9LPH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS07380
gene id: 416348:HLAC_RS07380
uniprot id: B9LNZ1
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS11915
gene id: 416348:HLAC_RS11915
uniprot id: B9LSM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

416348:HLAC RS02460
gene id: 416348:HLAC_RS02460
uniprot id: B9LT32
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

416348:HLAC RS08225
gene id: 416348:HLAC_RS08225
uniprot id: B9LPF1
names: Similarity
messages: Belongs to the LarC family.

416348:HLAC RS01900
gene id: 416348:HLAC_RS01900
uniprot id: B9LSE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

416348:HLAC RS14115
gene id: 416348:HLAC_RS14115
uniprot id: B9LW24
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

416348:HLAC RS09650
gene id: 416348:HLAC_RS09650
uniprot id: B9LQ98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

416348:HLAC RS01085
gene id: 416348:HLAC_RS01085
uniprot id: B9LRK0
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03470
gene id: 416348:HLAC_RS03470
uniprot id: B9LUE5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

416348:HLAC RS01245
gene id: 416348:HLAC_RS01245
uniprot id: B9LRN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

416348:HLAC RS02840
gene id: 416348:HLAC_RS02840
uniprot id: B9LTP0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

416348:HLAC RS03120
gene id: 416348:HLAC_RS03120
uniprot id: B9LTU7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

416348:HLAC RS09045
gene id: 416348:HLAC_RS09045
uniprot id: B9LPW1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

416348:HLAC RS04680
gene id: 416348:HLAC_RS04680
uniprot id: B9LMF8
names: Subcellular Location Annotation
messages: Cytoplasm

416348:HLAC RS03320
gene id: 416348:HLAC_RS03320
uniprot id: B9LUB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

416348:HLAC RS00500
gene id: 416348:HLAC_RS00500
uniprot id: B9LQV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

416348:HLAC RS07105
gene id: 416348:HLAC_RS07105
uniprot id: B9LNT3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

416348:HLAC RS08355
gene id: 416348:HLAC_RS08355
uniprot id: B9LPH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

416348:HLAC RS09590
gene id: 416348:HLAC_RS09590
uniprot id: B9LQ69
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

416348:HLAC RS01235
gene id: 416348:HLAC_RS01235
uniprot id: B9LRN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS15005
gene id: 416348:HLAC_RS15005
uniprot id: B9LV78
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

416348:HLAC RS10305
gene id: 416348:HLAC_RS10305
uniprot id: B9LQZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

416348:HLAC RS06145
gene id: 416348:HLAC_RS06145
uniprot id: B9LN94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

416348:HLAC RS12720
gene id: 416348:HLAC_RS12720
uniprot id: B9LTG3
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

416348:HLAC RS14160
gene id: 416348:HLAC_RS14160
uniprot id: B9LW34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

416348:HLAC RS14970
gene id: 416348:HLAC_RS14970
uniprot id: B9LV71
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

416348:HLAC RS11040
gene id: 416348:HLAC_RS11040
uniprot id: B9LRS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

416348:HLAC RS08085
gene id: 416348:HLAC_RS08085
uniprot id: B9LPC5
names: Similarity
messages: Belongs to the peptidase S8 family.

416348:HLAC RS11365
gene id: 416348:HLAC_RS11365
uniprot id: B9LRY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

416348:HLAC RS12430
gene id: 416348:HLAC_RS12430
uniprot id: B9LTA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

416348:HLAC RS10790
gene id: 416348:HLAC_RS10790
uniprot id: B9LR95
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

416348:HLAC RS12250
gene id: 416348:HLAC_RS12250
uniprot id: B9LT67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

416348:HLAC RS10645
gene id: 416348:HLAC_RS10645
uniprot id: B9LR63
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

416348:HLAC RS16390
gene id: 416348:HLAC_RS16390
uniprot id: B9LWQ1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

416348:HLAC RS05525
gene id: 416348:HLAC_RS05525
uniprot id: B9LMX3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

416348:HLAC RS01155
gene id: 416348:HLAC_RS01155
uniprot id: B9LRL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

416348:HLAC RS00915
gene id: 416348:HLAC_RS00915
uniprot id: B9LRG4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

416348:HLAC RS10920
gene id: 416348:HLAC_RS10920
uniprot id: B9LRQ2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

416348:HLAC RS09895
gene id: 416348:HLAC_RS09895
uniprot id: B9LQE7
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

416348:HLAC RS10700
gene id: 416348:HLAC_RS10700
uniprot id: B9LR74
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

416348:HLAC RS00295
gene id: 416348:HLAC_RS00295
uniprot id: B9LQR1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

416348:HLAC RS06345
gene id: 416348:HLAC_RS06345
uniprot id: B9LND4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

416348:HLAC RS16835
gene id: 416348:HLAC_RS16835
uniprot id: B9LWZ5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

416348:HLAC RS15935
gene id: 416348:HLAC_RS15935
uniprot id: B9LWF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

416348:HLAC RS02985
gene id: 416348:HLAC_RS02985
uniprot id: B9LTR9
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

416348:HLAC RS17480
gene id: 416348:HLAC_RS17480
uniprot id: B9LXE2
names: Subcellular Location Annotation
messages: Membrane

416348:HLAC RS03185
gene id: 416348:HLAC_RS03185
uniprot id: B9LTW0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

416348:HLAC RS09930
gene id: 416348:HLAC_RS09930
uniprot id: B9LQF4
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

416348:HLAC RS01395
gene id: 416348:HLAC_RS01395
uniprot id: B9LS41
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.