401472:CUREI RS00445
gene id: 401472:CUREI_RS00445
uniprot id: A0A077HIM8
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS09135
gene id: 401472:CUREI_RS09135
uniprot id: A0A077HS19
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

401472:CUREI RS08605
gene id: 401472:CUREI_RS08605
uniprot id: A0A077HK26
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS10510
gene id: 401472:CUREI_RS10510
uniprot id: A0A077HMP6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

401472:CUREI RS06985
gene id: 401472:CUREI_RS06985
uniprot id: A0A077HJ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

401472:CUREI RS11135
gene id: 401472:CUREI_RS11135
uniprot id: A0A077HSX0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

401472:CUREI RS05705
gene id: 401472:CUREI_RS05705
uniprot id: A0A077HIL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

401472:CUREI RS02330
gene id: 401472:CUREI_RS02330
uniprot id: A0A077HNU3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

401472:CUREI RS01115
gene id: 401472:CUREI_RS01115
uniprot id: A0A077HI69
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS03815
gene id: 401472:CUREI_RS03815
uniprot id: A0A077HK38
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

401472:CUREI RS03850
gene id: 401472:CUREI_RS03850
uniprot id: A0A077HJB1
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS09335
gene id: 401472:CUREI_RS09335
uniprot id: A0A077HS38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

401472:CUREI RS01470
gene id: 401472:CUREI_RS01470
uniprot id: A0A077HJ53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

401472:CUREI RS06890
gene id: 401472:CUREI_RS06890
uniprot id: A0A077HL77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

401472:CUREI RS06830
gene id: 401472:CUREI_RS06830
uniprot id: A0A077HLB6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

401472:CUREI RS09340
gene id: 401472:CUREI_RS09340
uniprot id: A0A077HK94
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

401472:CUREI RS05175
gene id: 401472:CUREI_RS05175
uniprot id: A0A077HIA0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS05725
gene id: 401472:CUREI_RS05725
uniprot id: A0A077HQE3
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

401472:CUREI RS01435
gene id: 401472:CUREI_RS01435
uniprot id: A0A077HN97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

401472:CUREI RS01050
gene id: 401472:CUREI_RS01050
uniprot id: A0A077HI60
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

401472:CUREI RS09260
gene id: 401472:CUREI_RS09260
uniprot id: A0A077HK83
names: Similarity
messages: Belongs to the PhoU family.

401472:CUREI RS01290
gene id: 401472:CUREI_RS01290
uniprot id: A0A077HN76
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS08945
gene id: 401472:CUREI_RS08945
uniprot id: A0A077HM15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

401472:CUREI RS08725
gene id: 401472:CUREI_RS08725
uniprot id: A0A077HM81
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

401472:CUREI RS02230
gene id: 401472:CUREI_RS02230
uniprot id: A0A077HJI8
names: Similarity
messages: Belongs to the AccD/PCCB family.

401472:CUREI RS08300
gene id: 401472:CUREI_RS08300
uniprot id: A0A077HLX3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

401472:CUREI RS11105
gene id: 401472:CUREI_RS11105
uniprot id: A0A077HMY4
names: Similarity
messages: Belongs to the ParB family.

401472:CUREI RS03585
gene id: 401472:CUREI_RS03585
uniprot id: A0A077HK08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

401472:CUREI RS00585
gene id: 401472:CUREI_RS00585
uniprot id: A0A077HIB7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

401472:CUREI RS00500
gene id: 401472:CUREI_RS00500
uniprot id: A0A077HHY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

401472:CUREI RS01815
gene id: 401472:CUREI_RS01815
uniprot id: A0A077HJA4
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

401472:CUREI RS00700
gene id: 401472:CUREI_RS00700
uniprot id: A0A077HMY5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

401472:CUREI RS04910
gene id: 401472:CUREI_RS04910
uniprot id: A0A077HKN0
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS06325
gene id: 401472:CUREI_RS06325
uniprot id: A0A077HKL0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

401472:CUREI RS08625
gene id: 401472:CUREI_RS08625
uniprot id: A0A077HLY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

401472:CUREI RS03935
gene id: 401472:CUREI_RS03935
uniprot id: A0A077HJC3
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

401472:CUREI RS02370
gene id: 401472:CUREI_RS02370
uniprot id: A0A077HH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpqB lipoprotein family.
messages: Cell membrane

401472:CUREI RS06405
gene id: 401472:CUREI_RS06405
uniprot id: A0A077HL02
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

401472:CUREI RS07885
gene id: 401472:CUREI_RS07885
uniprot id: A0A077HRE5
names: Similarity
messages: Belongs to the asparagine synthetase family.

401472:CUREI RS09455
gene id: 401472:CUREI_RS09455
uniprot id: A0A077HKA6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

401472:CUREI RS06345
gene id: 401472:CUREI_RS06345
uniprot id: A0A077HKZ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS08550
gene id: 401472:CUREI_RS08550
uniprot id: A0A077HK19
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

401472:CUREI RS09805
gene id: 401472:CUREI_RS09805
uniprot id: A0A077HKE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

401472:CUREI RS11120
gene id: 401472:CUREI_RS11120
uniprot id: A0A077HN11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

401472:CUREI RS07060
gene id: 401472:CUREI_RS07060
uniprot id: A0A077HJ34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

401472:CUREI RS01820
gene id: 401472:CUREI_RS01820
uniprot id: A0A077HJ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

401472:CUREI RS02730
gene id: 401472:CUREI_RS02730
uniprot id: A0A077HH79
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

401472:CUREI RS06365
gene id: 401472:CUREI_RS06365
uniprot id: A0A077HQN2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS06260
gene id: 401472:CUREI_RS06260
uniprot id: A0A077HIT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

401472:CUREI RS01480
gene id: 401472:CUREI_RS01480
uniprot id: A0A077HIC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

401472:CUREI RS09085
gene id: 401472:CUREI_RS09085
uniprot id: A0A077HM35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

401472:CUREI RS08415
gene id: 401472:CUREI_RS08415
uniprot id: A0A077HM42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

401472:CUREI RS01860
gene id: 401472:CUREI_RS01860
uniprot id: A0A077HGT0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

401472:CUREI RS00150
gene id: 401472:CUREI_RS00150
uniprot id: A0A077HI66
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

401472:CUREI RS00305
gene id: 401472:CUREI_RS00305
uniprot id: A0A077HMU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

401472:CUREI RS01705
gene id: 401472:CUREI_RS01705
uniprot id: A0A077HNF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

401472:CUREI RS05355
gene id: 401472:CUREI_RS05355
uniprot id: A0A077HQA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

401472:CUREI RS08930
gene id: 401472:CUREI_RS08930
uniprot id: A0A077HK51
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

401472:CUREI RS01850
gene id: 401472:CUREI_RS01850
uniprot id: A0A077HII3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

401472:CUREI RS01415
gene id: 401472:CUREI_RS01415
uniprot id: A0A077HJ49
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

401472:CUREI RS07605
gene id: 401472:CUREI_RS07605
uniprot id: A0A077HJE5
names: Similarity
messages: Belongs to the IMPACT family.

401472:CUREI RS01720
gene id: 401472:CUREI_RS01720
uniprot id: A0A077HIY9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

401472:CUREI RS07880
gene id: 401472:CUREI_RS07880
uniprot id: A0A077HLI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

401472:CUREI RS02385
gene id: 401472:CUREI_RS02385
uniprot id: A0A077HIR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

401472:CUREI RS05985
gene id: 401472:CUREI_RS05985
uniprot id: A0A077HIR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

401472:CUREI RS05620
gene id: 401472:CUREI_RS05620
uniprot id: A0A077HK97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

401472:CUREI RS01990
gene id: 401472:CUREI_RS01990
uniprot id: A0A077HJD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

401472:CUREI RS08615
gene id: 401472:CUREI_RS08615
uniprot id: A0A077HLZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

401472:CUREI RS11080
gene id: 401472:CUREI_RS11080
uniprot id: A0A077HMY0
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS05495
gene id: 401472:CUREI_RS05495
uniprot id: A0A077HK79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

401472:CUREI RS06580
gene id: 401472:CUREI_RS06580
uniprot id: A0A077HL26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

401472:CUREI RS09380
gene id: 401472:CUREI_RS09380
uniprot id: A0A077HM70
names: Similarity
messages: Belongs to the SAICAR synthetase family.

401472:CUREI RS00565
gene id: 401472:CUREI_RS00565
uniprot id: A0A077HHY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

401472:CUREI RS01600
gene id: 401472:CUREI_RS01600
uniprot id: A0A077HND2
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS03710
gene id: 401472:CUREI_RS03710
uniprot id: A0A077HPI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

401472:CUREI RS09095
gene id: 401472:CUREI_RS09095
uniprot id: A0A077HS14
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS02010
gene id: 401472:CUREI_RS02010
uniprot id: A0A077HNL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS03170
gene id: 401472:CUREI_RS03170
uniprot id: A0A077HIZ7
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

401472:CUREI RS03230
gene id: 401472:CUREI_RS03230
uniprot id: A0A077HJJ8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

401472:CUREI RS07445
gene id: 401472:CUREI_RS07445
uniprot id: A0A077HLJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

401472:CUREI RS06945
gene id: 401472:CUREI_RS06945
uniprot id: A0A077HL91
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

401472:CUREI RS05760
gene id: 401472:CUREI_RS05760
uniprot id: A0A077HL11
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

401472:CUREI RS01715
gene id: 401472:CUREI_RS01715
uniprot id: A0A077HJ92
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

401472:CUREI RS03885
gene id: 401472:CUREI_RS03885
uniprot id: A0A077HPK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS02435
gene id: 401472:CUREI_RS02435
uniprot id: A0A077HJC2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

401472:CUREI RS10455
gene id: 401472:CUREI_RS10455
uniprot id: A0A077HSJ8
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

401472:CUREI RS06400
gene id: 401472:CUREI_RS06400
uniprot id: A0A077HL76
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

401472:CUREI RS07295
gene id: 401472:CUREI_RS07295
uniprot id: A0A077HLH6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

401472:CUREI RS09945
gene id: 401472:CUREI_RS09945
uniprot id: A0A077HSB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS11095
gene id: 401472:CUREI_RS11095
uniprot id: A0A077HN07
names: Similarity
messages: Belongs to the thioredoxin family.

401472:CUREI RS10985
gene id: 401472:CUREI_RS10985
uniprot id: A0A077HL46
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS08870
gene id: 401472:CUREI_RS08870
uniprot id: A0A077HM97
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

401472:CUREI RS09230
gene id: 401472:CUREI_RS09230
uniprot id: A0A077HM54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

401472:CUREI RS03480
gene id: 401472:CUREI_RS03480
uniprot id: A0A077HPD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS06040
gene id: 401472:CUREI_RS06040
uniprot id: A0A077HL38
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

401472:CUREI RS02015
gene id: 401472:CUREI_RS02015
uniprot id: A0A077HGU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

401472:CUREI RS03505
gene id: 401472:CUREI_RS03505
uniprot id: A0A077HJ46
names: Similarity
messages: Belongs to the FPG family.

401472:CUREI RS05615
gene id: 401472:CUREI_RS05615
uniprot id: A0A077HKN5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS10675
gene id: 401472:CUREI_RS10675
uniprot id: A0A077HMS4
names: Similarity
messages: Belongs to the thioredoxin family.

401472:CUREI RS08500
gene id: 401472:CUREI_RS08500
uniprot id: A0A077HLY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

401472:CUREI RS00660
gene id: 401472:CUREI_RS00660
uniprot id: A0A077HMY1
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS00905
gene id: 401472:CUREI_RS00905
uniprot id: A0A077HN13
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

401472:CUREI RS00135
gene id: 401472:CUREI_RS00135
uniprot id: A0A077HMR7
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

401472:CUREI RS07625
gene id: 401472:CUREI_RS07625
uniprot id: A0A077HR89
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS06465
gene id: 401472:CUREI_RS06465
uniprot id: A0A077HL82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

401472:CUREI RS09680
gene id: 401472:CUREI_RS09680
uniprot id: A0A077HMB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS06185
gene id: 401472:CUREI_RS06185
uniprot id: A0A077HKX5
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

401472:CUREI RS02800
gene id: 401472:CUREI_RS02800
uniprot id: A0A077HJS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

401472:CUREI RS00390
gene id: 401472:CUREI_RS00390
uniprot id: A0A077HHW8
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS04925
gene id: 401472:CUREI_RS04925
uniprot id: A0A077HQ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

401472:CUREI RS09860
gene id: 401472:CUREI_RS09860
uniprot id: A0A077HKF2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

401472:CUREI RS00790
gene id: 401472:CUREI_RS00790
uniprot id: A0A077HIE7
names: Subcellular Location Annotation
messages: Cytoplasm

401472:CUREI RS09965
gene id: 401472:CUREI_RS09965
uniprot id: A0A077HMG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

401472:CUREI RS02510
gene id: 401472:CUREI_RS02510
uniprot id: A0A077HJC9
names: Similarity
messages: Belongs to the peptidase S16 family.

401472:CUREI RS04035
gene id: 401472:CUREI_RS04035
uniprot id: A0A077HPN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

401472:CUREI RS02755
gene id: 401472:CUREI_RS02755
uniprot id: A0A077HP45
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

401472:CUREI RS05570
gene id: 401472:CUREI_RS05570
uniprot id: A0A077HK88
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

401472:CUREI RS01550
gene id: 401472:CUREI_RS01550
uniprot id: A0A077HNC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

401472:CUREI RS06265
gene id: 401472:CUREI_RS06265
uniprot id: A0A077HL61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

401472:CUREI RS06380
gene id: 401472:CUREI_RS06380
uniprot id: A0A077HKZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

401472:CUREI RS05105
gene id: 401472:CUREI_RS05105
uniprot id: A0A077HQ57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS07405
gene id: 401472:CUREI_RS07405
uniprot id: A0A077HR48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

401472:CUREI RS09530
gene id: 401472:CUREI_RS09530
uniprot id: A0A077HS67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

401472:CUREI RS04300
gene id: 401472:CUREI_RS04300
uniprot id: A0A077HHU0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

401472:CUREI RS04940
gene id: 401472:CUREI_RS04940
uniprot id: A0A077HKC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

401472:CUREI RS04330
gene id: 401472:CUREI_RS04330
uniprot id: A0A077HKC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

401472:CUREI RS02105
gene id: 401472:CUREI_RS02105
uniprot id: A0A077HNN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

401472:CUREI RS02100
gene id: 401472:CUREI_RS02100
uniprot id: A0A077HIL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS00755
gene id: 401472:CUREI_RS00755
uniprot id: A0A077HGD7
names: Similarity
messages: Belongs to the GSP E family.

401472:CUREI RS06105
gene id: 401472:CUREI_RS06105
uniprot id: A0A077HKW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS00605
gene id: 401472:CUREI_RS00605
uniprot id: A0A077HIQ3
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

401472:CUREI RS06450
gene id: 401472:CUREI_RS06450
uniprot id: A0A077HKM6
names: Similarity
messages: Belongs to the peptidase M24B family.

401472:CUREI RS04570
gene id: 401472:CUREI_RS04570
uniprot id: A0A077HHX9
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS08640
gene id: 401472:CUREI_RS08640
uniprot id: A0A077HK29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

401472:CUREI RS10775
gene id: 401472:CUREI_RS10775
uniprot id: A0A077HMZ9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS01605
gene id: 401472:CUREI_RS01605
uniprot id: A0A077HGQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

401472:CUREI RS03950
gene id: 401472:CUREI_RS03950
uniprot id: A0A077HK63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

401472:CUREI RS11000
gene id: 401472:CUREI_RS11000
uniprot id: A0A077HMW6
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

401472:CUREI RS11020
gene id: 401472:CUREI_RS11020
uniprot id: A0A077HN36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

401472:CUREI RS06270
gene id: 401472:CUREI_RS06270
uniprot id: A0A077HKY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

401472:CUREI RS06775
gene id: 401472:CUREI_RS06775
uniprot id: A0A077HLA9
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

401472:CUREI RS05410
gene id: 401472:CUREI_RS05410
uniprot id: A0A077HIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

401472:CUREI RS06310
gene id: 401472:CUREI_RS06310
uniprot id: A0A077HIU1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

401472:CUREI RS06555
gene id: 401472:CUREI_RS06555
uniprot id: A0A077HQR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS03475
gene id: 401472:CUREI_RS03475
uniprot id: A0A077HJ40
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

401472:CUREI RS07970
gene id: 401472:CUREI_RS07970
uniprot id: A0A077HJM7
names: Similarity
messages: Belongs to the glutamine synthetase family.

401472:CUREI RS09070
gene id: 401472:CUREI_RS09070
uniprot id: A0A077HK62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS08995
gene id: 401472:CUREI_RS08995
uniprot id: A0A077HM22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

401472:CUREI RS07040
gene id: 401472:CUREI_RS07040
uniprot id: A0A077HLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

401472:CUREI RS01770
gene id: 401472:CUREI_RS01770
uniprot id: A0A077HGS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

401472:CUREI RS05140
gene id: 401472:CUREI_RS05140
uniprot id: A0A077HQ64
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

401472:CUREI RS06140
gene id: 401472:CUREI_RS06140
uniprot id: A0A077HKH7
names: Similarity
messages: Belongs to the UPF0237 family.

401472:CUREI RS01700
gene id: 401472:CUREI_RS01700
uniprot id: A0A077HIG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

401472:CUREI RS01695
gene id: 401472:CUREI_RS01695
uniprot id: A0A077HIY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

401472:CUREI RS09390
gene id: 401472:CUREI_RS09390
uniprot id: A0A077HM71
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

401472:CUREI RS07235
gene id: 401472:CUREI_RS07235
uniprot id: A0A077HLF9
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

401472:CUREI RS04110
gene id: 401472:CUREI_RS04110
uniprot id: A0A077HJF2
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS09650
gene id: 401472:CUREI_RS09650
uniprot id: A0A077HS79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

401472:CUREI RS03615
gene id: 401472:CUREI_RS03615
uniprot id: A0A077HJN7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

401472:CUREI RS07220
gene id: 401472:CUREI_RS07220
uniprot id: A0A077HJ75
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-72 and Arg-75) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

401472:CUREI RS00300
gene id: 401472:CUREI_RS00300
uniprot id: A0A077HHV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS08005
gene id: 401472:CUREI_RS08005
uniprot id: A0A077HLS0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

401472:CUREI RS00530
gene id: 401472:CUREI_RS00530
uniprot id: A0A077HIA9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

401472:CUREI RS00655
gene id: 401472:CUREI_RS00655
uniprot id: A0A077HI06
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS10555
gene id: 401472:CUREI_RS10555
uniprot id: A0A077HKT8
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS05535
gene id: 401472:CUREI_RS05535
uniprot id: A0A077HKZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

401472:CUREI RS00005
gene id: 401472:CUREI_RS00005
uniprot id: A0A077HHT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

401472:CUREI RS06795
gene id: 401472:CUREI_RS06795
uniprot id: A0A077HIZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

401472:CUREI RS10160
gene id: 401472:CUREI_RS10160
uniprot id: A0A077HSD9
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS05240
gene id: 401472:CUREI_RS05240
uniprot id: A0A077HKI1
names: Similarity
messages: Belongs to the isochorismate synthase family.

401472:CUREI RS04880
gene id: 401472:CUREI_RS04880
uniprot id: A0A077HI29
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

401472:CUREI RS01890
gene id: 401472:CUREI_RS01890
uniprot id: A0A077HGT3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

401472:CUREI RS03790
gene id: 401472:CUREI_RS03790
uniprot id: A0A077HJR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

401472:CUREI RS02300
gene id: 401472:CUREI_RS02300
uniprot id: A0A077HNT5
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

401472:CUREI RS01275
gene id: 401472:CUREI_RS01275
uniprot id: A0A077HJ30
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Could possibly oxidize fatty acids using specific components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS10890
gene id: 401472:CUREI_RS10890
uniprot id: A0A077HSR1
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS10830
gene id: 401472:CUREI_RS10830
uniprot id: A0A077HSQ1
names: Similarity
messages: Belongs to the UPF0371 family.

401472:CUREI RS09535
gene id: 401472:CUREI_RS09535
uniprot id: A0A077HKB7
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS05680
gene id: 401472:CUREI_RS05680
uniprot id: A0A077HL04
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS00560
gene id: 401472:CUREI_RS00560
uniprot id: A0A077HIB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

401472:CUREI RS01150
gene id: 401472:CUREI_RS01150
uniprot id: A0A077HGI3
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS06835
gene id: 401472:CUREI_RS06835
uniprot id: A0A077HL64
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS09730
gene id: 401472:CUREI_RS09730
uniprot id: A0A077HMB7
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS05960
gene id: 401472:CUREI_RS05960
uniprot id: A0A077HL30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

401472:CUREI RS06295
gene id: 401472:CUREI_RS06295
uniprot id: A0A077HKY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

401472:CUREI RS09790
gene id: 401472:CUREI_RS09790
uniprot id: A0A077HMM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

401472:CUREI RS08805
gene id: 401472:CUREI_RS08805
uniprot id: A0A077HM14
names: Similarity
messages: Belongs to the peptidase M1 family.

401472:CUREI RS01615
gene id: 401472:CUREI_RS01615
uniprot id: A0A077HIW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

401472:CUREI RS05190
gene id: 401472:CUREI_RS05190
uniprot id: A0A077HK04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

401472:CUREI RS00275
gene id: 401472:CUREI_RS00275
uniprot id: A0A077HHV6
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS09515
gene id: 401472:CUREI_RS09515
uniprot id: A0A077HMI9
names: Similarity
messages: Belongs to the Nth/MutY family.

401472:CUREI RS04615
gene id: 401472:CUREI_RS04615
uniprot id: A0A077HPU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

401472:CUREI RS00735
gene id: 401472:CUREI_RS00735
uniprot id: A0A077HIS1
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS04955
gene id: 401472:CUREI_RS04955
uniprot id: A0A077HI58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

401472:CUREI RS09585
gene id: 401472:CUREI_RS09585
uniprot id: A0A077HM99
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

401472:CUREI RS01840
gene id: 401472:CUREI_RS01840
uniprot id: A0A077HJB0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

401472:CUREI RS06000
gene id: 401472:CUREI_RS06000
uniprot id: A0A077HKF7
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

401472:CUREI RS05820
gene id: 401472:CUREI_RS05820
uniprot id: A0A077HL17
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS08745
gene id: 401472:CUREI_RS08745
uniprot id: A0A077HK37
names: Similarity
messages: Belongs to the EfeM/EfeO family.

401472:CUREI RS07400
gene id: 401472:CUREI_RS07400
uniprot id: A0A077HL80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

401472:CUREI RS01880
gene id: 401472:CUREI_RS01880
uniprot id: A0A077HII7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

401472:CUREI RS04930
gene id: 401472:CUREI_RS04930
uniprot id: A0A077HI52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

401472:CUREI RS07120
gene id: 401472:CUREI_RS07120
uniprot id: A0A077HJ44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

401472:CUREI RS09840
gene id: 401472:CUREI_RS09840
uniprot id: A0A077HMN0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS06010
gene id: 401472:CUREI_RS06010
uniprot id: A0A077HIR2
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

401472:CUREI RS07350
gene id: 401472:CUREI_RS07350
uniprot id: A0A077HR39
names: Similarity
messages: Belongs to the UPF0102 family.

401472:CUREI RS04975
gene id: 401472:CUREI_RS04975
uniprot id: A0A077HQ26
names: Similarity
messages: Belongs to the UPF0045 family.

401472:CUREI RS06255
gene id: 401472:CUREI_RS06255
uniprot id: A0A077HQL5
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

401472:CUREI RS09645
gene id: 401472:CUREI_RS09645
uniprot id: A0A077HMA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

401472:CUREI RS09075
gene id: 401472:CUREI_RS09075
uniprot id: A0A077HM40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

401472:CUREI RS10690
gene id: 401472:CUREI_RS10690
uniprot id: A0A077HSM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

401472:CUREI RS09580
gene id: 401472:CUREI_RS09580
uniprot id: A0A077HMJ5
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

401472:CUREI RS00595
gene id: 401472:CUREI_RS00595
uniprot id: A0A077HMX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

401472:CUREI RS10465
gene id: 401472:CUREI_RS10465
uniprot id: A0A077HMP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

401472:CUREI RS09035
gene id: 401472:CUREI_RS09035
uniprot id: A0A077HK58
names: Similarity
messages: Belongs to the fructosamine kinase family.

401472:CUREI RS05890
gene id: 401472:CUREI_RS05890
uniprot id: A0A077HQG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

401472:CUREI RS10440
gene id: 401472:CUREI_RS10440
uniprot id: A0A077HMN9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

401472:CUREI RS02580
gene id: 401472:CUREI_RS02580
uniprot id: A0A077HJD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

401472:CUREI RS05860
gene id: 401472:CUREI_RS05860
uniprot id: A0A077HQF8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

401472:CUREI RS06510
gene id: 401472:CUREI_RS06510
uniprot id: A0A077HIW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS00955
gene id: 401472:CUREI_RS00955
uniprot id: A0A077HI46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

401472:CUREI RS04315
gene id: 401472:CUREI_RS04315
uniprot id: A0A077HJI6
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

401472:CUREI RS04165
gene id: 401472:CUREI_RS04165
uniprot id: A0A077HJW4
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

401472:CUREI RS07240
gene id: 401472:CUREI_RS07240
uniprot id: A0A077HL60
names: Similarity
messages: Belongs to the MQO family.

401472:CUREI RS10815
gene id: 401472:CUREI_RS10815
uniprot id: A0A077HN04
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

401472:CUREI RS07610
gene id: 401472:CUREI_RS07610
uniprot id: A0A077HLL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

401472:CUREI RS11025
gene id: 401472:CUREI_RS11025
uniprot id: A0A077HMX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

401472:CUREI RS09285
gene id: 401472:CUREI_RS09285
uniprot id: A0A077HK87
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

401472:CUREI RS03185
gene id: 401472:CUREI_RS03185
uniprot id: A0A077HJW2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

401472:CUREI RS08835
gene id: 401472:CUREI_RS08835
uniprot id: A0A077HM17
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

401472:CUREI RS07680
gene id: 401472:CUREI_RS07680
uniprot id: A0A077HRA1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

401472:CUREI RS02340
gene id: 401472:CUREI_RS02340
uniprot id: A0A077HGZ2
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

401472:CUREI RS00335
gene id: 401472:CUREI_RS00335
uniprot id: A0A077HG85
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

401472:CUREI RS05515
gene id: 401472:CUREI_RS05515
uniprot id: A0A077HKM8
names: Similarity
messages: Belongs to the universal stress protein A family.

401472:CUREI RS07035
gene id: 401472:CUREI_RS07035
uniprot id: A0A077HJ29
names: Similarity
messages: Belongs to the YciI family.

401472:CUREI RS09120
gene id: 401472:CUREI_RS09120
uniprot id: A0A077HM43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS09500
gene id: 401472:CUREI_RS09500
uniprot id: A0A077HS64
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

401472:CUREI RS10625
gene id: 401472:CUREI_RS10625
uniprot id: A0A077HMR9
names: Similarity
messages: Belongs to the universal stress protein A family.

401472:CUREI RS04935
gene id: 401472:CUREI_RS04935
uniprot id: A0A077HKP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

401472:CUREI RS08590
gene id: 401472:CUREI_RS08590
uniprot id: A0A077HM66
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

401472:CUREI RS08810
gene id: 401472:CUREI_RS08810
uniprot id: A0A077HM89
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

401472:CUREI RS02565
gene id: 401472:CUREI_RS02565
uniprot id: A0A077HP11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

401472:CUREI RS09025
gene id: 401472:CUREI_RS09025
uniprot id: A0A077HM27
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

401472:CUREI RS00025
gene id: 401472:CUREI_RS00025
uniprot id: A0A077HI51
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

401472:CUREI RS00505
gene id: 401472:CUREI_RS00505
uniprot id: A0A077HMW7
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

401472:CUREI RS02470
gene id: 401472:CUREI_RS02470
uniprot id: A0A077HJC6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

401472:CUREI RS04530
gene id: 401472:CUREI_RS04530
uniprot id: A0A077HPT1
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

401472:CUREI RS07320
gene id: 401472:CUREI_RS07320
uniprot id: A0A077HR36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

401472:CUREI RS04145
gene id: 401472:CUREI_RS04145
uniprot id: A0A077HPP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

401472:CUREI RS09930
gene id: 401472:CUREI_RS09930
uniprot id: A0A077HMP3
names: Similarity
messages: Belongs to the peptidase C56 family.

401472:CUREI RS07485
gene id: 401472:CUREI_RS07485
uniprot id: A0A077HR58
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

401472:CUREI RS05185
gene id: 401472:CUREI_RS05185
uniprot id: A0A077HKG7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

401472:CUREI RS07325
gene id: 401472:CUREI_RS07325
uniprot id: A0A077HJ90
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

401472:CUREI RS00090
gene id: 401472:CUREI_RS00090
uniprot id: A0A077HI59
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

401472:CUREI RS09440
gene id: 401472:CUREI_RS09440
uniprot id: A0A077HMH7
names: Function
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

401472:CUREI RS07740
gene id: 401472:CUREI_RS07740
uniprot id: A0A077HJH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

401472:CUREI RS06415
gene id: 401472:CUREI_RS06415
uniprot id: A0A077HQP1
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

401472:CUREI RS06370
gene id: 401472:CUREI_RS06370
uniprot id: A0A077HIU7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS07765
gene id: 401472:CUREI_RS07765
uniprot id: A0A077HLF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

401472:CUREI RS08015
gene id: 401472:CUREI_RS08015
uniprot id: A0A077HLL8
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

401472:CUREI RS05250
gene id: 401472:CUREI_RS05250
uniprot id: A0A077HK15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

401472:CUREI RS08750
gene id: 401472:CUREI_RS08750
uniprot id: A0A077HM11
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

401472:CUREI RS09430
gene id: 401472:CUREI_RS09430
uniprot id: A0A077HKA3
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

401472:CUREI RS01455
gene id: 401472:CUREI_RS01455
uniprot id: A0A077HIC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

401472:CUREI RS02560
gene id: 401472:CUREI_RS02560
uniprot id: A0A077HIT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

401472:CUREI RS09780
gene id: 401472:CUREI_RS09780
uniprot id: A0A077HKD9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

401472:CUREI RS03730
gene id: 401472:CUREI_RS03730
uniprot id: A0A077HJQ3
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

401472:CUREI RS07695
gene id: 401472:CUREI_RS07695
uniprot id: A0A077HLN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

401472:CUREI RS08485
gene id: 401472:CUREI_RS08485
uniprot id: A0A077HLW3
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

401472:CUREI RS02570
gene id: 401472:CUREI_RS02570
uniprot id: A0A077HH61
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

401472:CUREI RS01120
gene id: 401472:CUREI_RS01120
uniprot id: A0A077HN50
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS06285
gene id: 401472:CUREI_RS06285
uniprot id: A0A077HIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

401472:CUREI RS04225
gene id: 401472:CUREI_RS04225
uniprot id: A0A077HKA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

401472:CUREI RS09685
gene id: 401472:CUREI_RS09685
uniprot id: A0A077HS82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS02270
gene id: 401472:CUREI_RS02270
uniprot id: A0A077HIP3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

401472:CUREI RS03655
gene id: 401472:CUREI_RS03655
uniprot id: A0A077HPH4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

401472:CUREI RS06530
gene id: 401472:CUREI_RS06530
uniprot id: A0A077HQR0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS01365
gene id: 401472:CUREI_RS01365
uniprot id: A0A077HGL9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

401472:CUREI RS11015
gene id: 401472:CUREI_RS11015
uniprot id: A0A077HMZ3
names: Function
names: Similarity
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

401472:CUREI RS03890
gene id: 401472:CUREI_RS03890
uniprot id: A0A077HHN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS07720
gene id: 401472:CUREI_RS07720
uniprot id: A0A077HLP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

401472:CUREI RS06320
gene id: 401472:CUREI_RS06320
uniprot id: A0A077HKZ1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

401472:CUREI RS06550
gene id: 401472:CUREI_RS06550
uniprot id: A0A077HKP8
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

401472:CUREI RS09695
gene id: 401472:CUREI_RS09695
uniprot id: A0A077HMB3
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

401472:CUREI RS10925
gene id: 401472:CUREI_RS10925
uniprot id: A0A077HL32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

401472:CUREI RS11115
gene id: 401472:CUREI_RS11115
uniprot id: A0A077HL88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

401472:CUREI RS04580
gene id: 401472:CUREI_RS04580
uniprot id: A0A077HK30
names: Similarity
messages: Belongs to the LOG family.

401472:CUREI RS04490
gene id: 401472:CUREI_RS04490
uniprot id: A0A077HK13
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS09030
gene id: 401472:CUREI_RS09030
uniprot id: A0A077HS05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

401472:CUREI RS00760
gene id: 401472:CUREI_RS00760
uniprot id: A0A077HIS6
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS07465
gene id: 401472:CUREI_RS07465
uniprot id: A0A077HJB3
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

401472:CUREI RS07645
gene id: 401472:CUREI_RS07645
uniprot id: A0A077HLM8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

401472:CUREI RS03610
gene id: 401472:CUREI_RS03610
uniprot id: A0A077HK12
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

401472:CUREI RS00570
gene id: 401472:CUREI_RS00570
uniprot id: A0A077HMX2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

401472:CUREI RS05395
gene id: 401472:CUREI_RS05395
uniprot id: A0A077HKL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

401472:CUREI RS06090
gene id: 401472:CUREI_RS06090
uniprot id: A0A077HQI8
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS05400
gene id: 401472:CUREI_RS05400
uniprot id: A0A077HK70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS07965
gene id: 401472:CUREI_RS07965
uniprot id: A0A077HRG5
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS07925
gene id: 401472:CUREI_RS07925
uniprot id: A0A077HLT7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

401472:CUREI RS05950
gene id: 401472:CUREI_RS05950
uniprot id: A0A077HQG8
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.

401472:CUREI RS03740
gene id: 401472:CUREI_RS03740
uniprot id: A0A077HPJ2
names: Caution
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS07670
gene id: 401472:CUREI_RS07670
uniprot id: A0A077HLN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

401472:CUREI RS01885
gene id: 401472:CUREI_RS01885
uniprot id: A0A077HNJ0
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

401472:CUREI RS00580
gene id: 401472:CUREI_RS00580
uniprot id: A0A077HIP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

401472:CUREI RS01055
gene id: 401472:CUREI_RS01055
uniprot id: A0A077HN38
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

401472:CUREI RS03785
gene id: 401472:CUREI_RS03785
uniprot id: A0A077HK36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

401472:CUREI RS05815
gene id: 401472:CUREI_RS05815
uniprot id: A0A077HIN5
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS01520
gene id: 401472:CUREI_RS01520
uniprot id: A0A077HID0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

401472:CUREI RS07385
gene id: 401472:CUREI_RS07385
uniprot id: A0A077HJ97
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

401472:CUREI RS10695
gene id: 401472:CUREI_RS10695
uniprot id: A0A077HKX3
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS05525
gene id: 401472:CUREI_RS05525
uniprot id: A0A077HQC8
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS10050
gene id: 401472:CUREI_RS10050
uniprot id: A0A077HMF9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

401472:CUREI RS04895
gene id: 401472:CUREI_RS04895
uniprot id: A0A077HJT8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

401472:CUREI RS08305
gene id: 401472:CUREI_RS08305
uniprot id: A0A077HM20
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

401472:CUREI RS09315
gene id: 401472:CUREI_RS09315
uniprot id: A0A077HM64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

401472:CUREI RS08940
gene id: 401472:CUREI_RS08940
uniprot id: A0A077HMA5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

401472:CUREI RS01075
gene id: 401472:CUREI_RS01075
uniprot id: A0A077HIZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS08430
gene id: 401472:CUREI_RS08430
uniprot id: A0A077HK03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

401472:CUREI RS04255
gene id: 401472:CUREI_RS04255
uniprot id: A0A077HJX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

401472:CUREI RS05065
gene id: 401472:CUREI_RS05065
uniprot id: A0A077HKR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS08565
gene id: 401472:CUREI_RS08565
uniprot id: A0A077HLX5
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS06885
gene id: 401472:CUREI_RS06885
uniprot id: A0A077HLC4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

401472:CUREI RS03925
gene id: 401472:CUREI_RS03925
uniprot id: A0A077HK60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

401472:CUREI RS01980
gene id: 401472:CUREI_RS01980
uniprot id: A0A077HNL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

401472:CUREI RS05020
gene id: 401472:CUREI_RS05020
uniprot id: A0A077HJW6
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

401472:CUREI RS03795
gene id: 401472:CUREI_RS03795
uniprot id: A0A077HJA0
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

401472:CUREI RS03895
gene id: 401472:CUREI_RS03895
uniprot id: A0A077HK55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS07435
gene id: 401472:CUREI_RS07435
uniprot id: A0A077HR51
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

401472:CUREI RS09040
gene id: 401472:CUREI_RS09040
uniprot id: A0A077HM36
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

401472:CUREI RS09250
gene id: 401472:CUREI_RS09250
uniprot id: A0A077HM50
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

401472:CUREI RS05545
gene id: 401472:CUREI_RS05545
uniprot id: A0A077HK85
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

401472:CUREI RS07940
gene id: 401472:CUREI_RS07940
uniprot id: A0A077HRF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

401472:CUREI RS07750
gene id: 401472:CUREI_RS07750
uniprot id: A0A077HLQ0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS05225
gene id: 401472:CUREI_RS05225
uniprot id: A0A077HQ80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS09715
gene id: 401472:CUREI_RS09715
uniprot id: A0A077HS86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

401472:CUREI RS05685
gene id: 401472:CUREI_RS05685
uniprot id: A0A077HKP1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

401472:CUREI RS06445
gene id: 401472:CUREI_RS06445
uniprot id: A0A077HL06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

401472:CUREI RS00865
gene id: 401472:CUREI_RS00865
uniprot id: A0A077HIW3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

401472:CUREI RS03520
gene id: 401472:CUREI_RS03520
uniprot id: A0A077HK00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

401472:CUREI RS00290
gene id: 401472:CUREI_RS00290
uniprot id: A0A077HIK2
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

401472:CUREI RS00635
gene id: 401472:CUREI_RS00635
uniprot id: A0A077HGC3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

401472:CUREI RS10055
gene id: 401472:CUREI_RS10055
uniprot id: A0A077HMQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

401472:CUREI RS01015
gene id: 401472:CUREI_RS01015
uniprot id: A0A077HII8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

401472:CUREI RS08120
gene id: 401472:CUREI_RS08120
uniprot id: A0A077HJT1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

401472:CUREI RS06500
gene id: 401472:CUREI_RS06500
uniprot id: A0A077HKN7
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

401472:CUREI RS09550
gene id: 401472:CUREI_RS09550
uniprot id: A0A077HMJ2
names: Similarity
messages: Belongs to the pantothenate synthetase family.

401472:CUREI RS01775
gene id: 401472:CUREI_RS01775
uniprot id: A0A077HJ99
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

401472:CUREI RS04735
gene id: 401472:CUREI_RS04735
uniprot id: A0A077HPW6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS09010
gene id: 401472:CUREI_RS09010
uniprot id: A0A077HM33
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

401472:CUREI RS02490
gene id: 401472:CUREI_RS02490
uniprot id: A0A077HP03
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

401472:CUREI RS07305
gene id: 401472:CUREI_RS07305
uniprot id: A0A077HLG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

401472:CUREI RS03555
gene id: 401472:CUREI_RS03555
uniprot id: A0A077HJN3
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS02145
gene id: 401472:CUREI_RS02145
uniprot id: A0A077HJG9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

401472:CUREI RS04055
gene id: 401472:CUREI_RS04055
uniprot id: A0A077HJE2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

401472:CUREI RS09000
gene id: 401472:CUREI_RS09000
uniprot id: A0A077HS02
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

401472:CUREI RS08420
gene id: 401472:CUREI_RS08420
uniprot id: A0A077HLV7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

401472:CUREI RS03345
gene id: 401472:CUREI_RS03345
uniprot id: A0A077HJL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

401472:CUREI RS04865
gene id: 401472:CUREI_RS04865
uniprot id: A0A077HKA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

401472:CUREI RS09865
gene id: 401472:CUREI_RS09865
uniprot id: A0A077HMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

401472:CUREI RS04900
gene id: 401472:CUREI_RS04900
uniprot id: A0A077HQ07
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

401472:CUREI RS06840
gene id: 401472:CUREI_RS06840
uniprot id: A0A077HKV0
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

401472:CUREI RS09975
gene id: 401472:CUREI_RS09975
uniprot id: A0A077HKH6
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

401472:CUREI RS00360
gene id: 401472:CUREI_RS00360
uniprot id: A0A077HHW6
names: Similarity
messages: Belongs to the peptidase M13 family.

401472:CUREI RS06545
gene id: 401472:CUREI_RS06545
uniprot id: A0A077HL21
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

401472:CUREI RS05840
gene id: 401472:CUREI_RS05840
uniprot id: A0A077HIP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

401472:CUREI RS01580
gene id: 401472:CUREI_RS01580
uniprot id: A0A077HGP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS10910
gene id: 401472:CUREI_RS10910
uniprot id: A0A077HN19
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS05845
gene id: 401472:CUREI_RS05845
uniprot id: A0A077HL19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

401472:CUREI RS05590
gene id: 401472:CUREI_RS05590
uniprot id: A0A077HKN4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

401472:CUREI RS00985
gene id: 401472:CUREI_RS00985
uniprot id: A0A077HII2
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

401472:CUREI RS11130
gene id: 401472:CUREI_RS11130
uniprot id: A0A077HMY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

401472:CUREI RS06280
gene id: 401472:CUREI_RS06280
uniprot id: A0A077HQL9
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

401472:CUREI RS02630
gene id: 401472:CUREI_RS02630
uniprot id: A0A077HJQ9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS02575
gene id: 401472:CUREI_RS02575
uniprot id: A0A077HJQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

401472:CUREI RS04150
gene id: 401472:CUREI_RS04150
uniprot id: A0A077HHS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

401472:CUREI RS01680
gene id: 401472:CUREI_RS01680
uniprot id: A0A077HNF5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

401472:CUREI RS00220
gene id: 401472:CUREI_RS00220
uniprot id: A0A077HIJ3
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS01465
gene id: 401472:CUREI_RS01465
uniprot id: A0A077HGN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

401472:CUREI RS06590
gene id: 401472:CUREI_RS06590
uniprot id: A0A077HKQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

401472:CUREI RS08280
gene id: 401472:CUREI_RS08280
uniprot id: A0A077HM10
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

401472:CUREI RS02415
gene id: 401472:CUREI_RS02415
uniprot id: A0A077HNZ3
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

401472:CUREI RS03635
gene id: 401472:CUREI_RS03635
uniprot id: A0A077HK16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

401472:CUREI RS07170
gene id: 401472:CUREI_RS07170
uniprot id: A0A077HJ61
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

401472:CUREI RS05605
gene id: 401472:CUREI_RS05605
uniprot id: A0A077HIJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

401472:CUREI RS00015
gene id: 401472:CUREI_RS00015
uniprot id: A0A077HG51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

401472:CUREI RS00805
gene id: 401472:CUREI_RS00805
uniprot id: A0A077HGE4
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

401472:CUREI RS05610
gene id: 401472:CUREI_RS05610
uniprot id: A0A077HKZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

401472:CUREI RS07275
gene id: 401472:CUREI_RS07275
uniprot id: A0A077HL63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

401472:CUREI RS10200
gene id: 401472:CUREI_RS10200
uniprot id: A0A077HKK9
names: Similarity
messages: Belongs to the AccD/PCCB family.

401472:CUREI RS10315
gene id: 401472:CUREI_RS10315
uniprot id: A0A077HMU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

401472:CUREI RS07370
gene id: 401472:CUREI_RS07370
uniprot id: A0A077HLI2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

401472:CUREI RS01080
gene id: 401472:CUREI_RS01080
uniprot id: A0A077HIJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

401472:CUREI RS07195
gene id: 401472:CUREI_RS07195
uniprot id: A0A077HJ67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS09280
gene id: 401472:CUREI_RS09280
uniprot id: A0A077HS31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

401472:CUREI RS03595
gene id: 401472:CUREI_RS03595
uniprot id: A0A077HJ65
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

401472:CUREI RS02075
gene id: 401472:CUREI_RS02075
uniprot id: A0A077HNN0
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

401472:CUREI RS08380
gene id: 401472:CUREI_RS08380
uniprot id: A0A077HLY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

401472:CUREI RS05625
gene id: 401472:CUREI_RS05625
uniprot id: A0A077HQD7
names: Similarity
messages: Belongs to the UPF0434 family.

401472:CUREI RS04030
gene id: 401472:CUREI_RS04030
uniprot id: A0A077HJD7
names: Similarity
messages: Belongs to the DNA photolyase family.

401472:CUREI RS10450
gene id: 401472:CUREI_RS10450
uniprot id: A0A077HMN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

401472:CUREI RS03200
gene id: 401472:CUREI_RS03200
uniprot id: A0A077HPA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

401472:CUREI RS02260
gene id: 401472:CUREI_RS02260
uniprot id: A0A077HJJ3
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

401472:CUREI RS09970
gene id: 401472:CUREI_RS09970
uniprot id: A0A077HSB2
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

401472:CUREI RS01565
gene id: 401472:CUREI_RS01565
uniprot id: A0A077HIU9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

401472:CUREI RS07705
gene id: 401472:CUREI_RS07705
uniprot id: A0A077HRA8
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

401472:CUREI RS02615
gene id: 401472:CUREI_RS02615
uniprot id: A0A077HIU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

401472:CUREI RS04965
gene id: 401472:CUREI_RS04965
uniprot id: A0A077HKD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

401472:CUREI RS08680
gene id: 401472:CUREI_RS08680
uniprot id: A0A077HM78
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

401472:CUREI RS07725
gene id: 401472:CUREI_RS07725
uniprot id: A0A077HLE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS07390
gene id: 401472:CUREI_RS07390
uniprot id: A0A077HLI8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

401472:CUREI RS08065
gene id: 401472:CUREI_RS08065
uniprot id: A0A077HLV8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

401472:CUREI RS06760
gene id: 401472:CUREI_RS06760
uniprot id: A0A077HQT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

401472:CUREI RS06420
gene id: 401472:CUREI_RS06420
uniprot id: A0A077HIV5
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

401472:CUREI RS10960
gene id: 401472:CUREI_RS10960
uniprot id: A0A077HL40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

401472:CUREI RS04640
gene id: 401472:CUREI_RS04640
uniprot id: A0A077HJN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

401472:CUREI RS11085
gene id: 401472:CUREI_RS11085
uniprot id: A0A077HSV6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

401472:CUREI RS04155
gene id: 401472:CUREI_RS04155
uniprot id: A0A077HK90
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

401472:CUREI RS01095
gene id: 401472:CUREI_RS01095
uniprot id: A0A077HN43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS08400
gene id: 401472:CUREI_RS08400
uniprot id: A0A077HJZ8
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS09610
gene id: 401472:CUREI_RS09610
uniprot id: A0A077HMJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

401472:CUREI RS05550
gene id: 401472:CUREI_RS05550
uniprot id: A0A077HQC9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

401472:CUREI RS00885
gene id: 401472:CUREI_RS00885
uniprot id: A0A077HGF1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

401472:CUREI RS10835
gene id: 401472:CUREI_RS10835
uniprot id: A0A077HL08
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS01560
gene id: 401472:CUREI_RS01560
uniprot id: A0A077HJ66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

401472:CUREI RS08425
gene id: 401472:CUREI_RS08425
uniprot id: A0A077HRS6
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

401472:CUREI RS00140
gene id: 401472:CUREI_RS00140
uniprot id: A0A077HG59
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

401472:CUREI RS07950
gene id: 401472:CUREI_RS07950
uniprot id: A0A077HLR3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

401472:CUREI RS07335
gene id: 401472:CUREI_RS07335
uniprot id: A0A077HLI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

401472:CUREI RS04890
gene id: 401472:CUREI_RS04890
uniprot id: A0A077HKB6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS03685
gene id: 401472:CUREI_RS03685
uniprot id: A0A077HPI1
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS04510
gene id: 401472:CUREI_RS04510
uniprot id: A0A077HKG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

401472:CUREI RS09915
gene id: 401472:CUREI_RS09915
uniprot id: A0A077HKG3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

401472:CUREI RS06455
gene id: 401472:CUREI_RS06455
uniprot id: A0A077HQP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

401472:CUREI RS06340
gene id: 401472:CUREI_RS06340
uniprot id: A0A077HL69
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

401472:CUREI RS01970
gene id: 401472:CUREI_RS01970
uniprot id: A0A077HJ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

401472:CUREI RS07690
gene id: 401472:CUREI_RS07690
uniprot id: A0A077HLM9
names: Similarity
messages: Belongs to the YggT family.

401472:CUREI RS07415
gene id: 401472:CUREI_RS07415
uniprot id: A0A077HLJ2
names: Similarity
messages: Belongs to the acylphosphatase family.

401472:CUREI RS09670
gene id: 401472:CUREI_RS09670
uniprot id: A0A077HMK5
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS02170
gene id: 401472:CUREI_RS02170
uniprot id: A0A077HJH5
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

401472:CUREI RS01760
gene id: 401472:CUREI_RS01760
uniprot id: A0A077HIG9
names: Similarity
messages: Belongs to the WXG100 family.

401472:CUREI RS03600
gene id: 401472:CUREI_RS03600
uniprot id: A0A077HPG0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

401472:CUREI RS06005
gene id: 401472:CUREI_RS06005
uniprot id: A0A077HQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

401472:CUREI RS06940
gene id: 401472:CUREI_RS06940
uniprot id: A0A077HLD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS01525
gene id: 401472:CUREI_RS01525
uniprot id: A0A077HNB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

401472:CUREI RS07010
gene id: 401472:CUREI_RS07010
uniprot id: A0A077HJ25
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS07110
gene id: 401472:CUREI_RS07110
uniprot id: A0A077HL29
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

401472:CUREI RS01125
gene id: 401472:CUREI_RS01125
uniprot id: A0A077HGH9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

401472:CUREI RS05385
gene id: 401472:CUREI_RS05385
uniprot id: A0A077HIF2
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

401472:CUREI RS10620
gene id: 401472:CUREI_RS10620
uniprot id: A0A077HKV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

401472:CUREI RS01475
gene id: 401472:CUREI_RS01475
uniprot id: A0A077HIS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

401472:CUREI RS07945
gene id: 401472:CUREI_RS07945
uniprot id: A0A077HJM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

401472:CUREI RS06330
gene id: 401472:CUREI_RS06330
uniprot id: A0A077HQM8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

401472:CUREI RS04085
gene id: 401472:CUREI_RS04085
uniprot id: A0A077HPN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS02885
gene id: 401472:CUREI_RS02885
uniprot id: A0A077HLA7
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS07165
gene id: 401472:CUREI_RS07165
uniprot id: A0A077HR17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

401472:CUREI RS07910
gene id: 401472:CUREI_RS07910
uniprot id: A0A077HRF2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

401472:CUREI RS04870
gene id: 401472:CUREI_RS04870
uniprot id: A0A077HJT3
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

401472:CUREI RS08495
gene id: 401472:CUREI_RS08495
uniprot id: A0A077HK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS06460
gene id: 401472:CUREI_RS06460
uniprot id: A0A077HIV7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS04860
gene id: 401472:CUREI_RS04860
uniprot id: A0A077HKL8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

401472:CUREI RS06490
gene id: 401472:CUREI_RS06490
uniprot id: A0A077HL84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

401472:CUREI RS01710
gene id: 401472:CUREI_RS01710
uniprot id: A0A077HGR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

401472:CUREI RS02115
gene id: 401472:CUREI_RS02115
uniprot id: A0A077HJG3
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS07360
gene id: 401472:CUREI_RS07360
uniprot id: A0A077HLI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

401472:CUREI RS07665
gene id: 401472:CUREI_RS07665
uniprot id: A0A077HLM7
names: Similarity
messages: Belongs to the asparaginase 1 family.

401472:CUREI RS02380
gene id: 401472:CUREI_RS02380
uniprot id: A0A077HJA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

401472:CUREI RS09295
gene id: 401472:CUREI_RS09295
uniprot id: A0A077HMF2
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

401472:CUREI RS05170
gene id: 401472:CUREI_RS05170
uniprot id: A0A077HQ70
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS07510
gene id: 401472:CUREI_RS07510
uniprot id: A0A077HLA0
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

401472:CUREI RS10380
gene id: 401472:CUREI_RS10380
uniprot id: A0A077HMM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

401472:CUREI RS03940
gene id: 401472:CUREI_RS03940
uniprot id: A0A077HPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

401472:CUREI RS01335
gene id: 401472:CUREI_RS01335
uniprot id: A0A077HGL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

401472:CUREI RS00515
gene id: 401472:CUREI_RS00515
uniprot id: A0A077HGA6
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS07685
gene id: 401472:CUREI_RS07685
uniprot id: A0A077HJG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

401472:CUREI RS05730
gene id: 401472:CUREI_RS05730
uniprot id: A0A077HIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

401472:CUREI RS01655
gene id: 401472:CUREI_RS01655
uniprot id: A0A077HGR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

401472:CUREI RS01530
gene id: 401472:CUREI_RS01530
uniprot id: A0A077HGP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

401472:CUREI RS09545
gene id: 401472:CUREI_RS09545
uniprot id: A0A077HM98
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS09910
gene id: 401472:CUREI_RS09910
uniprot id: A0A077HSA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

401472:CUREI RS01665
gene id: 401472:CUREI_RS01665
uniprot id: A0A077HIX9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

401472:CUREI RS07855
gene id: 401472:CUREI_RS07855
uniprot id: A0A077HRE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
messages: Membrane

401472:CUREI RS06525
gene id: 401472:CUREI_RS06525
uniprot id: A0A077HKP4
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

401472:CUREI RS08845
gene id: 401472:CUREI_RS08845
uniprot id: A0A077HM93
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

401472:CUREI RS01610
gene id: 401472:CUREI_RS01610
uniprot id: A0A077HJ76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

401472:CUREI RS05675
gene id: 401472:CUREI_RS05675
uniprot id: A0A077HIL0
names: Similarity
messages: Belongs to the TlyA family.

401472:CUREI RS07815
gene id: 401472:CUREI_RS07815
uniprot id: A0A077HLP5
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

401472:CUREI RS04755
gene id: 401472:CUREI_RS04755
uniprot id: A0A077HK74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

401472:CUREI RS06915
gene id: 401472:CUREI_RS06915
uniprot id: A0A077HL85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

401472:CUREI RS07340
gene id: 401472:CUREI_RS07340
uniprot id: A0A077HLH5
names: Similarity
messages: Belongs to the DprA/Smf family.

401472:CUREI RS07460
gene id: 401472:CUREI_RS07460
uniprot id: A0A077HR54
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

401472:CUREI RS08685
gene id: 401472:CUREI_RS08685
uniprot id: A0A077HLZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

401472:CUREI RS06870
gene id: 401472:CUREI_RS06870
uniprot id: A0A077HQV7
names: Subcellular Location Annotation
messages: Cytoplasm

401472:CUREI RS06395
gene id: 401472:CUREI_RS06395
uniprot id: A0A077HIV1
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS02080
gene id: 401472:CUREI_RS02080
uniprot id: A0A077HGU9
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

401472:CUREI RS08535
gene id: 401472:CUREI_RS08535
uniprot id: A0A077HM58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

401472:CUREI RS06825
gene id: 401472:CUREI_RS06825
uniprot id: A0A077HIZ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS11220
gene id: 401472:CUREI_RS11220
uniprot id: A0A077HLA7
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS06410
gene id: 401472:CUREI_RS06410
uniprot id: A0A077HKM1
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

401472:CUREI RS10485
gene id: 401472:CUREI_RS10485
uniprot id: A0A077HKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

401472:CUREI RS07345
gene id: 401472:CUREI_RS07345
uniprot id: A0A077HL72
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

401472:CUREI RS04065
gene id: 401472:CUREI_RS04065
uniprot id: A0A077HHQ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

401472:CUREI RS07185
gene id: 401472:CUREI_RS07185
uniprot id: A0A077HL49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

401472:CUREI RS02165
gene id: 401472:CUREI_RS02165
uniprot id: A0A077HGW3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

401472:CUREI RS07745
gene id: 401472:CUREI_RS07745
uniprot id: A0A077HLN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

401472:CUREI RS01440
gene id: 401472:CUREI_RS01440
uniprot id: A0A077HGM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

401472:CUREI RS10290
gene id: 401472:CUREI_RS10290
uniprot id: A0A077HML1
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

401472:CUREI RS08320
gene id: 401472:CUREI_RS08320
uniprot id: A0A077HJY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

401472:CUREI RS06030
gene id: 401472:CUREI_RS06030
uniprot id: A0A077HQI0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

401472:CUREI RS00850
gene id: 401472:CUREI_RS00850
uniprot id: A0A077HI33
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

401472:CUREI RS09960
gene id: 401472:CUREI_RS09960
uniprot id: A0A077HMP7
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

401472:CUREI RS05580
gene id: 401472:CUREI_RS05580
uniprot id: A0A077HIJ4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

401472:CUREI RS02640
gene id: 401472:CUREI_RS02640
uniprot id: A0A077HIU5
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS08405
gene id: 401472:CUREI_RS08405
uniprot id: A0A077HLY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

401472:CUREI RS05945
gene id: 401472:CUREI_RS05945
uniprot id: A0A077HKF0
names: Similarity
messages: Belongs to the prokaryotic ubiquitin-like protein family.

401472:CUREI RS09395
gene id: 401472:CUREI_RS09395
uniprot id: A0A077HS48
names: Similarity
messages: Belongs to the GARS family.

401472:CUREI RS04075
gene id: 401472:CUREI_RS04075
uniprot id: A0A077HJV3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS01620
gene id: 401472:CUREI_RS01620
uniprot id: A0A077HIE9
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS01675
gene id: 401472:CUREI_RS01675
uniprot id: A0A077HIF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

401472:CUREI RS07985
gene id: 401472:CUREI_RS07985
uniprot id: A0A077HLL1
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

401472:CUREI RS07130
gene id: 401472:CUREI_RS07130
uniprot id: A0A077HLD5
names: Similarity
messages: Belongs to the ribF family.

401472:CUREI RS01375
gene id: 401472:CUREI_RS01375
uniprot id: A0A077HIQ6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

401472:CUREI RS08585
gene id: 401472:CUREI_RS08585
uniprot id: A0A077HLZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

401472:CUREI RS05630
gene id: 401472:CUREI_RS05630
uniprot id: A0A077HIK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS00440
gene id: 401472:CUREI_RS00440
uniprot id: A0A077HG96
names: Similarity
messages: Belongs to the ABC transporter superfamily.

401472:CUREI RS01765
gene id: 401472:CUREI_RS01765
uniprot id: A0A077HNG9
names: Similarity
messages: Belongs to the WXG100 family.

401472:CUREI RS08595
gene id: 401472:CUREI_RS08595
uniprot id: A0A077HLY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

401472:CUREI RS10170
gene id: 401472:CUREI_RS10170
uniprot id: A0A077HMI6
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS01785
gene id: 401472:CUREI_RS01785
uniprot id: A0A077HIZ8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

401472:CUREI RS00610
gene id: 401472:CUREI_RS00610
uniprot id: A0A077HIC2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS09575
gene id: 401472:CUREI_RS09575
uniprot id: A0A077HMA1
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

401472:CUREI RS04560
gene id: 401472:CUREI_RS04560
uniprot id: A0A077HJM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

401472:CUREI RS03560
gene id: 401472:CUREI_RS03560
uniprot id: A0A077HJ60
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

401472:CUREI RS01385
gene id: 401472:CUREI_RS01385
uniprot id: A0A077HN92
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

401472:CUREI RS05205
gene id: 401472:CUREI_RS05205
uniprot id: A0A077HKU2
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS07410
gene id: 401472:CUREI_RS07410
uniprot id: A0A077HJA2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

401472:CUREI RS09600
gene id: 401472:CUREI_RS09600
uniprot id: A0A077HKC0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

401472:CUREI RS09595
gene id: 401472:CUREI_RS09595
uniprot id: A0A077HS73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

401472:CUREI RS06060
gene id: 401472:CUREI_RS06060
uniprot id: A0A077HIR7
names: Similarity
messages: Belongs to the UPF0098 family.

401472:CUREI RS08020
gene id: 401472:CUREI_RS08020
uniprot id: A0A077HRH6
names: Similarity
messages: Belongs to the glutamine synthetase family.

401472:CUREI RS07280
gene id: 401472:CUREI_RS07280
uniprot id: A0A077HR34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

401472:CUREI RS09920
gene id: 401472:CUREI_RS09920
uniprot id: A0A077HME2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

401472:CUREI RS04990
gene id: 401472:CUREI_RS04990
uniprot id: A0A077HKD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

401472:CUREI RS10155
gene id: 401472:CUREI_RS10155
uniprot id: A0A077HMJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

401472:CUREI RS05600
gene id: 401472:CUREI_RS05600
uniprot id: A0A077HQD5
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

401472:CUREI RS02420
gene id: 401472:CUREI_RS02420
uniprot id: A0A077HH41
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

401472:CUREI RS01985
gene id: 401472:CUREI_RS01985
uniprot id: A0A077HGU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

401472:CUREI RS06335
gene id: 401472:CUREI_RS06335
uniprot id: A0A077HIU3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

401472:CUREI RS01855
gene id: 401472:CUREI_RS01855
uniprot id: A0A077HNI3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

401472:CUREI RS01425
gene id: 401472:CUREI_RS01425
uniprot id: A0A077HIB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

401472:CUREI RS08965
gene id: 401472:CUREI_RS08965
uniprot id: A0A077HMA9
names: Similarity
messages: Belongs to the peptidase S58 family.

401472:CUREI RS08730
gene id: 401472:CUREI_RS08730
uniprot id: A0A077HLZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

401472:CUREI RS08395
gene id: 401472:CUREI_RS08395
uniprot id: A0A077HRS0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

401472:CUREI RS05370
gene id: 401472:CUREI_RS05370
uniprot id: A0A077HKK3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

401472:CUREI RS01570
gene id: 401472:CUREI_RS01570
uniprot id: A0A077HIE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

401472:CUREI RS05990
gene id: 401472:CUREI_RS05990
uniprot id: A0A077HL33
names: Similarity
messages: Belongs to the peptidase M18 family.

401472:CUREI RS01540
gene id: 401472:CUREI_RS01540
uniprot id: A0A077HIT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

401472:CUREI RS07570
gene id: 401472:CUREI_RS07570
uniprot id: A0A077HLB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

401472:CUREI RS02585
gene id: 401472:CUREI_RS02585
uniprot id: A0A077HIU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

401472:CUREI RS09020
gene id: 401472:CUREI_RS09020
uniprot id: A0A077HMB6
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

401472:CUREI RS03705
gene id: 401472:CUREI_RS03705
uniprot id: A0A077HJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

401472:CUREI RS09130
gene id: 401472:CUREI_RS09130
uniprot id: A0A077HM37
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

401472:CUREI RS07070
gene id: 401472:CUREI_RS07070
uniprot id: A0A077HLE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

401472:CUREI RS10770
gene id: 401472:CUREI_RS10770
uniprot id: A0A077HMU5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

401472:CUREI RS10885
gene id: 401472:CUREI_RS10885
uniprot id: A0A077HMU8
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS08875
gene id: 401472:CUREI_RS08875
uniprot id: A0A077HM09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

401472:CUREI RS09475
gene id: 401472:CUREI_RS09475
uniprot id: A0A077HS60
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS05095
gene id: 401472:CUREI_RS05095
uniprot id: A0A077HKE8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

401472:CUREI RS00100
gene id: 401472:CUREI_RS00100
uniprot id: A0A077HHU2
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS05925
gene id: 401472:CUREI_RS05925
uniprot id: A0A077HQG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

401472:CUREI RS08705
gene id: 401472:CUREI_RS08705
uniprot id: A0A077HK35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

401472:CUREI RS05050
gene id: 401472:CUREI_RS05050
uniprot id: A0A077HJX3
names: Similarity
messages: Belongs to the CsoR family.

401472:CUREI RS00765
gene id: 401472:CUREI_RS00765
uniprot id: A0A077HIE3
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS04685
gene id: 401472:CUREI_RS04685
uniprot id: A0A077HK57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

401472:CUREI RS06610
gene id: 401472:CUREI_RS06610
uniprot id: A0A077HL31
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

401472:CUREI RS01685
gene id: 401472:CUREI_RS01685
uniprot id: A0A077HGR1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

401472:CUREI RS07915
gene id: 401472:CUREI_RS07915
uniprot id: A0A077HJL6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

401472:CUREI RS05335
gene id: 401472:CUREI_RS05335
uniprot id: A0A077HIC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

401472:CUREI RS04220
gene id: 401472:CUREI_RS04220
uniprot id: A0A077HHS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

401472:CUREI RS05955
gene id: 401472:CUREI_RS05955
uniprot id: A0A077HIQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

401472:CUREI RS10365
gene id: 401472:CUREI_RS10365
uniprot id: A0A077HKP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

401472:CUREI RS03880
gene id: 401472:CUREI_RS03880
uniprot id: A0A077HJB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS03175
gene id: 401472:CUREI_RS03175
uniprot id: A0A077HPA0
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

401472:CUREI RS03735
gene id: 401472:CUREI_RS03735
uniprot id: A0A077HJ91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

401472:CUREI RS05330
gene id: 401472:CUREI_RS05330
uniprot id: A0A077HQ96
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

401472:CUREI RS05830
gene id: 401472:CUREI_RS05830
uniprot id: A0A077HKD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

401472:CUREI RS12555
gene id: 401472:CUREI_RS12555
uniprot id: A0A077HM05
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

401472:CUREI RS00315
gene id: 401472:CUREI_RS00315
uniprot id: A0A077HIK7
names: Caution
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS01650
gene id: 401472:CUREI_RS01650
uniprot id: A0A077HNE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

401472:CUREI RS05510
gene id: 401472:CUREI_RS05510
uniprot id: A0A077HKY8
names: Similarity
messages: Belongs to the universal stress protein A family.

401472:CUREI RS01310
gene id: 401472:CUREI_RS01310
uniprot id: A0A077HIA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

401472:CUREI RS00055
gene id: 401472:CUREI_RS00055
uniprot id: A0A077HHT9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

401472:CUREI RS09725
gene id: 401472:CUREI_RS09725
uniprot id: A0A077HKD1
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

401472:CUREI RS07735
gene id: 401472:CUREI_RS07735
uniprot id: A0A077HRB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

401472:CUREI RS07015
gene id: 401472:CUREI_RS07015
uniprot id: A0A077HLE1
names: Similarity
messages: Belongs to the PspA/IM30 family.

401472:CUREI RS08365
gene id: 401472:CUREI_RS08365
uniprot id: A0A077HLV1
names: Similarity
messages: Belongs to the Fur family.

401472:CUREI RS03920
gene id: 401472:CUREI_RS03920
uniprot id: A0A077HHN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

401472:CUREI RS10515
gene id: 401472:CUREI_RS10515
uniprot id: A0A077HSK5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

401472:CUREI RS08510
gene id: 401472:CUREI_RS08510
uniprot id: A0A077HLW8
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

401472:CUREI RS07955
gene id: 401472:CUREI_RS07955
uniprot id: A0A077HLT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

401472:CUREI RS08795
gene id: 401472:CUREI_RS08795
uniprot id: A0A077HRX5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

401472:CUREI RS06075
gene id: 401472:CUREI_RS06075
uniprot id: A0A077HKW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS04135
gene id: 401472:CUREI_RS04135
uniprot id: A0A077HJW1
names: Similarity
messages: Belongs to the FBPase class 2 family.

401472:CUREI RS06575
gene id: 401472:CUREI_RS06575
uniprot id: A0A077HL93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

401472:CUREI RS07000
gene id: 401472:CUREI_RS07000
uniprot id: A0A077HKZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

401472:CUREI RS08355
gene id: 401472:CUREI_RS08355
uniprot id: A0A077HM32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS05080
gene id: 401472:CUREI_RS05080
uniprot id: A0A077HQ50
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

401472:CUREI RS09605
gene id: 401472:CUREI_RS09605
uniprot id: A0A077HMA3
names: Similarity
messages: Belongs to the peptidase S13 family.

401472:CUREI RS01350
gene id: 401472:CUREI_RS01350
uniprot id: A0A077HIA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

401472:CUREI RS04080
gene id: 401472:CUREI_RS04080
uniprot id: A0A077HJE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

401472:CUREI RS00825
gene id: 401472:CUREI_RS00825
uniprot id: A0A077HI30
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

401472:CUREI RS07135
gene id: 401472:CUREI_RS07135
uniprot id: A0A077HL37
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

401472:CUREI RS11010
gene id: 401472:CUREI_RS11010
uniprot id: A0A077HL54
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS06025
gene id: 401472:CUREI_RS06025
uniprot id: A0A077HKG2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

401472:CUREI RS03535
gene id: 401472:CUREI_RS03535
uniprot id: A0A077HPE5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

401472:CUREI RS01270
gene id: 401472:CUREI_RS01270
uniprot id: A0A077HGK5
names: Similarity
messages: Belongs to the peptidase M20A family.

401472:CUREI RS06390
gene id: 401472:CUREI_RS06390
uniprot id: A0A077HQN6
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

401472:CUREI RS04565
gene id: 401472:CUREI_RS04565
uniprot id: A0A077HPT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

401472:CUREI RS04920
gene id: 401472:CUREI_RS04920
uniprot id: A0A077HJU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

401472:CUREI RS04875
gene id: 401472:CUREI_RS04875
uniprot id: A0A077HPZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

401472:CUREI RS06865
gene id: 401472:CUREI_RS06865
uniprot id: A0A077HKW1
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

401472:CUREI RS06905
gene id: 401472:CUREI_RS06905
uniprot id: A0A077HJ09
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

401472:CUREI RS05015
gene id: 401472:CUREI_RS05015
uniprot id: A0A077HKD7
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

401472:CUREI RS01410
gene id: 401472:CUREI_RS01410
uniprot id: A0A077HGM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

401472:CUREI RS05145
gene id: 401472:CUREI_RS05145
uniprot id: A0A077HI93
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

401472:CUREI RS01545
gene id: 401472:CUREI_RS01545
uniprot id: A0A077HID3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

401472:CUREI RS07180
gene id: 401472:CUREI_RS07180
uniprot id: A0A077HLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

401472:CUREI RS09890
gene id: 401472:CUREI_RS09890
uniprot id: A0A077HMD9
names: Similarity
messages: Belongs to the TPP enzyme family.

401472:CUREI RS11060
gene id: 401472:CUREI_RS11060
uniprot id: A0A077HL71
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

401472:CUREI RS05980
gene id: 401472:CUREI_RS05980
uniprot id: A0A077HQH2
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

401472:CUREI RS01645
gene id: 401472:CUREI_RS01645
uniprot id: A0A077HIF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

401472:CUREI RS07810
gene id: 401472:CUREI_RS07810
uniprot id: A0A077HJJ0
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

401472:CUREI RS07265
gene id: 401472:CUREI_RS07265
uniprot id: A0A077HLG3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

401472:CUREI RS05780
gene id: 401472:CUREI_RS05780
uniprot id: A0A077HKB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

401472:CUREI RS03195
gene id: 401472:CUREI_RS03195
uniprot id: A0A077HJ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

401472:CUREI RS06495
gene id: 401472:CUREI_RS06495
uniprot id: A0A077HL13
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

401472:CUREI RS01865
gene id: 401472:CUREI_RS01865
uniprot id: A0A077HJB4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

401472:CUREI RS06180
gene id: 401472:CUREI_RS06180
uniprot id: A0A077HL53
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

401472:CUREI RS03590
gene id: 401472:CUREI_RS03590
uniprot id: A0A077HJN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

401472:CUREI RS01045
gene id: 401472:CUREI_RS01045
uniprot id: A0A077HIJ2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

401472:CUREI RS03330
gene id: 401472:CUREI_RS03330
uniprot id: A0A077HPB8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

401472:CUREI RS08980
gene id: 401472:CUREI_RS08980
uniprot id: A0A077HK54
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

401472:CUREI RS02220
gene id: 401472:CUREI_RS02220
uniprot id: A0A077HNR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

401472:CUREI RS05150
gene id: 401472:CUREI_RS05150
uniprot id: A0A077HKT2
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS00010
gene id: 401472:CUREI_RS00010
uniprot id: A0A077HMP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

401472:CUREI RS07770
gene id: 401472:CUREI_RS07770
uniprot id: A0A077HRC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

401472:CUREI RS01950
gene id: 401472:CUREI_RS01950
uniprot id: A0A077HIJ6
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

401472:CUREI RS06990
gene id: 401472:CUREI_RS06990
uniprot id: A0A077HLD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

401472:CUREI RS04175
gene id: 401472:CUREI_RS04175
uniprot id: A0A077HJG2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

401472:CUREI RS11125
gene id: 401472:CUREI_RS11125
uniprot id: A0A077HN56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

401472:CUREI RS05155
gene id: 401472:CUREI_RS05155
uniprot id: A0A077HKG1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

401472:CUREI RS01160
gene id: 401472:CUREI_RS01160
uniprot id: A0A077HIL5
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS09065
gene id: 401472:CUREI_RS09065
uniprot id: A0A077HS10
names: Similarity
messages: Belongs to the phosphohexose mutase family.

401472:CUREI RS00795
gene id: 401472:CUREI_RS00795
uniprot id: A0A077HI27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS05880
gene id: 401472:CUREI_RS05880
uniprot id: A0A077HKE2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS05735
gene id: 401472:CUREI_RS05735
uniprot id: A0A077HL09
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

401472:CUREI RS10705
gene id: 401472:CUREI_RS10705
uniprot id: A0A077HMZ0
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

401472:CUREI RS00520
gene id: 401472:CUREI_RS00520
uniprot id: A0A077HIN6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS01180
gene id: 401472:CUREI_RS01180
uniprot id: A0A077HJ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

401472:CUREI RS04635
gene id: 401472:CUREI_RS04635
uniprot id: A0A077HK42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

401472:CUREI RS01660
gene id: 401472:CUREI_RS01660
uniprot id: A0A077HJ85
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

401472:CUREI RS02790
gene id: 401472:CUREI_RS02790
uniprot id: A0A077HP50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

401472:CUREI RS03700
gene id: 401472:CUREI_RS03700
uniprot id: A0A077HJP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

401472:CUREI RS10855
gene id: 401472:CUREI_RS10855
uniprot id: A0A077HSQ6
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS02795
gene id: 401472:CUREI_RS02795
uniprot id: A0A077HH88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

401472:CUREI RS03305
gene id: 401472:CUREI_RS03305
uniprot id: A0A077HPB6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

401472:CUREI RS05195
gene id: 401472:CUREI_RS05195
uniprot id: A0A077HQ75
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS05505
gene id: 401472:CUREI_RS05505
uniprot id: A0A077HII0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

401472:CUREI RS06620
gene id: 401472:CUREI_RS06620
uniprot id: A0A077HQS3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

401472:CUREI RS06470
gene id: 401472:CUREI_RS06470
uniprot id: A0A077HL10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

401472:CUREI RS09825
gene id: 401472:CUREI_RS09825
uniprot id: A0A077HS98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

401472:CUREI RS09450
gene id: 401472:CUREI_RS09450
uniprot id: A0A077HS56
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

401472:CUREI RS04945
gene id: 401472:CUREI_RS04945
uniprot id: A0A077HJV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

401472:CUREI RS00180
gene id: 401472:CUREI_RS00180
uniprot id: A0A077HII6
names: Subcellular Location Annotation
messages: Membrane

401472:CUREI RS08375
gene id: 401472:CUREI_RS08375
uniprot id: A0A077HJZ1
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

401472:CUREI RS07440
gene id: 401472:CUREI_RS07440
uniprot id: A0A077HJA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

401472:CUREI RS07700
gene id: 401472:CUREI_RS07700
uniprot id: A0A077HLE3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

401472:CUREI RS04125
gene id: 401472:CUREI_RS04125
uniprot id: A0A077HHR6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

401472:CUREI RS01555
gene id: 401472:CUREI_RS01555
uniprot id: A0A077HGP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

401472:CUREI RS01420
gene id: 401472:CUREI_RS01420
uniprot id: A0A077HIR1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

401472:CUREI RS04605
gene id: 401472:CUREI_RS04605
uniprot id: A0A077HK39
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

401472:CUREI RS09240
gene id: 401472:CUREI_RS09240
uniprot id: A0A077HME3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.

401472:CUREI RS06980
gene id: 401472:CUREI_RS06980
uniprot id: A0A077HQX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

401472:CUREI RS01535
gene id: 401472:CUREI_RS01535
uniprot id: A0A077HJ62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

401472:CUREI RS00160
gene id: 401472:CUREI_RS00160
uniprot id: A0A077HHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

401472:CUREI RS07115
gene id: 401472:CUREI_RS07115
uniprot id: A0A077HR06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

401472:CUREI RS09905
gene id: 401472:CUREI_RS09905
uniprot id: A0A077HMF1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

401472:CUREI RS02805
gene id: 401472:CUREI_RS02805
uniprot id: A0A077HJF5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

401472:CUREI RS05090
gene id: 401472:CUREI_RS05090
uniprot id: A0A077HKS0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

401472:CUREI RS02355
gene id: 401472:CUREI_RS02355
uniprot id: A0A077HIQ5
names: Similarity
messages: Belongs to the thymidylate kinase family.

401472:CUREI RS06275
gene id: 401472:CUREI_RS06275
uniprot id: A0A077HKK0
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

401472:CUREI RS06240
gene id: 401472:CUREI_RS06240
uniprot id: A0A077HL59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

401472:CUREI RS03985
gene id: 401472:CUREI_RS03985
uniprot id: A0A077HJU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

401472:CUREI RS04855
gene id: 401472:CUREI_RS04855
uniprot id: A0A077HI26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

401472:CUREI RS07875
gene id: 401472:CUREI_RS07875
uniprot id: A0A077HLS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

401472:CUREI RS07860
gene id: 401472:CUREI_RS07860
uniprot id: A0A077HJK4
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

401472:CUREI RS08445
gene id: 401472:CUREI_RS08445
uniprot id: A0A077HLW0
names: Similarity
messages: Belongs to the disproportionating enzyme family.

401472:CUREI RS09330
gene id: 401472:CUREI_RS09330
uniprot id: A0A077HM62
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.