398579:SPEA RS02030
gene id: 398579:SPEA_RS02030
uniprot id: A8GZG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

398579:SPEA RS13380
gene id: 398579:SPEA_RS13380
uniprot id: A8H5L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

398579:SPEA RS12755
gene id: 398579:SPEA_RS12755
uniprot id: A8H590
names: Similarity
messages: Belongs to the transglycosylase Slt family.

398579:SPEA RS09235
gene id: 398579:SPEA_RS09235
uniprot id: A8H3E4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

398579:SPEA RS03315
gene id: 398579:SPEA_RS03315
uniprot id: A8H067
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS21045
gene id: 398579:SPEA_RS21045
uniprot id: A8H9T2
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS10025
gene id: 398579:SPEA_RS10025
uniprot id: A8H3U9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

398579:SPEA RS14630
gene id: 398579:SPEA_RS14630
uniprot id: A8H697
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

398579:SPEA RS02370
gene id: 398579:SPEA_RS02370
uniprot id: A8GZN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

398579:SPEA RS06245
gene id: 398579:SPEA_RS06245
uniprot id: A8H1T6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

398579:SPEA RS01345
gene id: 398579:SPEA_RS01345
uniprot id: A8GZ35
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

398579:SPEA RS20205
gene id: 398579:SPEA_RS20205
uniprot id: A8H9B9
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

398579:SPEA RS01875
gene id: 398579:SPEA_RS01875
uniprot id: A8GZE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

398579:SPEA RS03375
gene id: 398579:SPEA_RS03375
uniprot id: A8H079
names: Similarity
messages: Belongs to the catalase family.

398579:SPEA RS12090
gene id: 398579:SPEA_RS12090
uniprot id: A8H4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

398579:SPEA RS15725
gene id: 398579:SPEA_RS15725
uniprot id: A8H6W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
messages: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS12475
gene id: 398579:SPEA_RS12475
uniprot id: A8H539
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

398579:SPEA RS12320
gene id: 398579:SPEA_RS12320
uniprot id: A8H521
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS13230
gene id: 398579:SPEA_RS13230
uniprot id: A8H5I3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

398579:SPEA RS19840
gene id: 398579:SPEA_RS19840
uniprot id: A8H952
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

398579:SPEA RS16090
gene id: 398579:SPEA_RS16090
uniprot id: A8H734
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer.
messages: May be involved in cell division.

398579:SPEA RS15780
gene id: 398579:SPEA_RS15780
uniprot id: A8H6X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

398579:SPEA RS14515
gene id: 398579:SPEA_RS14515
uniprot id: A8H675
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

398579:SPEA RS04065
gene id: 398579:SPEA_RS04065
uniprot id: A8H0L2
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

398579:SPEA RS20840
gene id: 398579:SPEA_RS20840
uniprot id: A8H9P4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

398579:SPEA RS12120
gene id: 398579:SPEA_RS12120
uniprot id: A8H4Y3
names: Similarity
messages: Belongs to the peptidase S8 family.

398579:SPEA RS10860
gene id: 398579:SPEA_RS10860
uniprot id: A8H4A6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

398579:SPEA RS22120
gene id: 398579:SPEA_RS22120
uniprot id: A8HAE2
names: Similarity
messages: Belongs to the peptidase S41A family.

398579:SPEA RS00565
gene id: 398579:SPEA_RS00565
uniprot id: A8GYP6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS08220
gene id: 398579:SPEA_RS08220
uniprot id: A8H2U5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS15190
gene id: 398579:SPEA_RS15190
uniprot id: A8H6K7
names: Similarity
messages: Belongs to the skp family.

398579:SPEA RS00780
gene id: 398579:SPEA_RS00780
uniprot id: A8GYU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP H family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS18600
gene id: 398579:SPEA_RS18600
uniprot id: A8H8G3
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

398579:SPEA RS06070
gene id: 398579:SPEA_RS06070
uniprot id: A8H1Q2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

398579:SPEA RS13635
gene id: 398579:SPEA_RS13635
uniprot id: A8H5Q2
names: Similarity
messages: Belongs to the peptidase S9A family.

398579:SPEA RS14235
gene id: 398579:SPEA_RS14235
uniprot id: A8H619
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

398579:SPEA RS05905
gene id: 398579:SPEA_RS05905
uniprot id: A8H1L9
names: Similarity
messages: Belongs to the GSP E family.

398579:SPEA RS05615
gene id: 398579:SPEA_RS05615
uniprot id: A8H1G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS17240
gene id: 398579:SPEA_RS17240
uniprot id: A8H7P4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

398579:SPEA RS21270
gene id: 398579:SPEA_RS21270
uniprot id: A8H9X7
names: Similarity
messages: Belongs to the transglycosylase Slt family.

398579:SPEA RS15205
gene id: 398579:SPEA_RS15205
uniprot id: A8H6L0
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

398579:SPEA RS14155
gene id: 398579:SPEA_RS14155
uniprot id: A8H606
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS22215
gene id: 398579:SPEA_RS22215
uniprot id: A8HAF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

398579:SPEA RS16600
gene id: 398579:SPEA_RS16600
uniprot id: A8H7C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

398579:SPEA RS11480
gene id: 398579:SPEA_RS11480
uniprot id: A8H4M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

398579:SPEA RS06205
gene id: 398579:SPEA_RS06205
uniprot id: A8H1S8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

398579:SPEA RS10665
gene id: 398579:SPEA_RS10665
uniprot id: A8H467
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS20845
gene id: 398579:SPEA_RS20845
uniprot id: A8H9P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

398579:SPEA RS13620
gene id: 398579:SPEA_RS13620
uniprot id: A8H5P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

398579:SPEA RS15635
gene id: 398579:SPEA_RS15635
uniprot id: A8H6U4
names: Similarity
messages: Belongs to the glutathione peroxidase family.

398579:SPEA RS14150
gene id: 398579:SPEA_RS14150
uniprot id: A8H605
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

398579:SPEA RS17625
gene id: 398579:SPEA_RS17625
uniprot id: A8H7X1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Exported by the Tat system.
messages: Periplasm
messages: Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.

398579:SPEA RS00800
gene id: 398579:SPEA_RS00800
uniprot id: A8GYU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP L family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

398579:SPEA RS22220
gene id: 398579:SPEA_RS22220
uniprot id: A8HAF7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS01150
gene id: 398579:SPEA_RS01150
uniprot id: A8GZ05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

398579:SPEA RS20550
gene id: 398579:SPEA_RS20550
uniprot id: A8H9I6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxine kinase family. PdxY subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.

398579:SPEA RS07770
gene id: 398579:SPEA_RS07770
uniprot id: A8H2K3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.
messages: Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate.
messages: Glycosidase.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

398579:SPEA RS21490
gene id: 398579:SPEA_RS21490
uniprot id: A8HA20
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

398579:SPEA RS10245
gene id: 398579:SPEA_RS10245
uniprot id: A8H3Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

398579:SPEA RS15085
gene id: 398579:SPEA_RS15085
uniprot id: A8H6I6
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

398579:SPEA RS05350
gene id: 398579:SPEA_RS05350
uniprot id: A8H1B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

398579:SPEA RS01445
gene id: 398579:SPEA_RS01445
uniprot id: A8GZ55
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

398579:SPEA RS05485
gene id: 398579:SPEA_RS05485
uniprot id: A8H1E2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

398579:SPEA RS10070
gene id: 398579:SPEA_RS10070
uniprot id: A8H3V8
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

398579:SPEA RS11515
gene id: 398579:SPEA_RS11515
uniprot id: A8H4M8
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

398579:SPEA RS14250
gene id: 398579:SPEA_RS14250
uniprot id: A8H622
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

398579:SPEA RS13405
gene id: 398579:SPEA_RS13405
uniprot id: A8H5L8
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

398579:SPEA RS10175
gene id: 398579:SPEA_RS10175
uniprot id: A8H3X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapC family.
messages: Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
messages: Cytoplasm
messages: Interacts directly with FtsZ.

398579:SPEA RS07235
gene id: 398579:SPEA_RS07235
uniprot id: A8H2C2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

398579:SPEA RS00940
gene id: 398579:SPEA_RS00940
uniprot id: A8GYW3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS17330
gene id: 398579:SPEA_RS17330
uniprot id: A8H7R2
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS04900
gene id: 398579:SPEA_RS04900
uniprot id: A8H127
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

398579:SPEA RS16615
gene id: 398579:SPEA_RS16615
uniprot id: A8H7C5
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

398579:SPEA RS14545
gene id: 398579:SPEA_RS14545
uniprot id: A8H681
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS08465
gene id: 398579:SPEA_RS08465
uniprot id: A8H2Z7
names: Similarity
messages: Belongs to the DSD1 family.

398579:SPEA RS10895
gene id: 398579:SPEA_RS10895
uniprot id: A8H4B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

398579:SPEA RS10775
gene id: 398579:SPEA_RS10775
uniprot id: A8H489
names: Similarity
messages: Belongs to the phosphohexose mutase family.

398579:SPEA RS20010
gene id: 398579:SPEA_RS20010
uniprot id: A8H980
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

398579:SPEA RS00860
gene id: 398579:SPEA_RS00860
uniprot id: A8GYV6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

398579:SPEA RS04035
gene id: 398579:SPEA_RS04035
uniprot id: A8H0K6
names: Similarity
messages: Belongs to the SufE family.

398579:SPEA RS04515
gene id: 398579:SPEA_RS04515
uniprot id: A8H0V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

398579:SPEA RS05475
gene id: 398579:SPEA_RS05475
uniprot id: A8H1E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

398579:SPEA RS06850
gene id: 398579:SPEA_RS06850
uniprot id: A8H248
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

398579:SPEA RS11510
gene id: 398579:SPEA_RS11510
uniprot id: A8H4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

398579:SPEA RS02080
gene id: 398579:SPEA_RS02080
uniprot id: A8GZH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

398579:SPEA RS21185
gene id: 398579:SPEA_RS21185
uniprot id: A8H9W0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS05800
gene id: 398579:SPEA_RS05800
uniprot id: A8H1J8
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

398579:SPEA RS16120
gene id: 398579:SPEA_RS16120
uniprot id: A8H740
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

398579:SPEA RS18530
gene id: 398579:SPEA_RS18530
uniprot id: A8H8E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

398579:SPEA RS02130
gene id: 398579:SPEA_RS02130
uniprot id: A8GZI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

398579:SPEA RS20835
gene id: 398579:SPEA_RS20835
uniprot id: A8H9P3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS03965
gene id: 398579:SPEA_RS03965
uniprot id: A8H0J2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

398579:SPEA RS13725
gene id: 398579:SPEA_RS13725
uniprot id: A8H5S0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS06015
gene id: 398579:SPEA_RS06015
uniprot id: A8H1P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS03085
gene id: 398579:SPEA_RS03085
uniprot id: A8H019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

398579:SPEA RS07360
gene id: 398579:SPEA_RS07360
uniprot id: A8H2E7
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS10530
gene id: 398579:SPEA_RS10530
uniprot id: A8H441
names: Similarity
messages: Belongs to the YkuD family.

398579:SPEA RS20110
gene id: 398579:SPEA_RS20110
uniprot id: A8H9A0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS22270
gene id: 398579:SPEA_RS22270
uniprot id: A8HAG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

398579:SPEA RS19515
gene id: 398579:SPEA_RS19515
uniprot id: A8H8Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraB family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
messages: Interacts with the C-terminal region of Rne.

398579:SPEA RS01000
gene id: 398579:SPEA_RS01000
uniprot id: A8GYX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

398579:SPEA RS13245
gene id: 398579:SPEA_RS13245
uniprot id: A8H5I6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

398579:SPEA RS02890
gene id: 398579:SPEA_RS02890
uniprot id: A8GZY0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

398579:SPEA RS01275
gene id: 398579:SPEA_RS01275
uniprot id: A8GZ21
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

398579:SPEA RS11850
gene id: 398579:SPEA_RS11850
uniprot id: A8H4U1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

398579:SPEA RS19630
gene id: 398579:SPEA_RS19630
uniprot id: A8H910
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

398579:SPEA RS02110
gene id: 398579:SPEA_RS02110
uniprot id: A8GZI4
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: The fumarate reductase enzyme complex is required for fumarate respiration. This subunit anchors the complex in the membrane and binds a diheme cytochrome b.

398579:SPEA RS03680
gene id: 398579:SPEA_RS03680
uniprot id: A8H0D7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

398579:SPEA RS10470
gene id: 398579:SPEA_RS10470
uniprot id: A8H430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

398579:SPEA RS15375
gene id: 398579:SPEA_RS15375
uniprot id: A8H6P4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

398579:SPEA RS14125
gene id: 398579:SPEA_RS14125
uniprot id: A8H600
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS16200
gene id: 398579:SPEA_RS16200
uniprot id: A8H754
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS18570
gene id: 398579:SPEA_RS18570
uniprot id: A8H8F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS22285
gene id: 398579:SPEA_RS22285
uniprot id: A8HAH0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS11345
gene id: 398579:SPEA_RS11345
uniprot id: A8H4J4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

398579:SPEA RS01035
gene id: 398579:SPEA_RS01035
uniprot id: A8GYY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

398579:SPEA RS07555
gene id: 398579:SPEA_RS07555
uniprot id: A8H2I6
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

398579:SPEA RS21030
gene id: 398579:SPEA_RS21030
uniprot id: A8H9S9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

398579:SPEA RS13105
gene id: 398579:SPEA_RS13105
uniprot id: A8H5G0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

398579:SPEA RS04525
gene id: 398579:SPEA_RS04525
uniprot id: A8H0V4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

398579:SPEA RS20315
gene id: 398579:SPEA_RS20315
uniprot id: A8H9E0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS10630
gene id: 398579:SPEA_RS10630
uniprot id: A8H460
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

398579:SPEA RS11865
gene id: 398579:SPEA_RS11865
uniprot id: A8H4U4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

398579:SPEA RS20380
gene id: 398579:SPEA_RS20380
uniprot id: A8H9F2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

398579:SPEA RS03685
gene id: 398579:SPEA_RS03685
uniprot id: A8H0D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

398579:SPEA RS19820
gene id: 398579:SPEA_RS19820
uniprot id: A8H948
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

398579:SPEA RS06165
gene id: 398579:SPEA_RS06165
uniprot id: A8H1S0
names: Subcellular Location Annotation
messages: Cell inner membrane

398579:SPEA RS21500
gene id: 398579:SPEA_RS21500
uniprot id: A8HA22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

398579:SPEA RS15210
gene id: 398579:SPEA_RS15210
uniprot id: A8H6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

398579:SPEA RS02560
gene id: 398579:SPEA_RS02560
uniprot id: A8GZS0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multiheme cytochrome c family.
messages: Binds 8 heme c groups covalently per monomer.
messages: Exposure to oxygen reduces copper binding and leads to the formation of a disulfide bond between the two Cys residues that bind the copper ion.
messages: Periplasm
messages: Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process.

398579:SPEA RS19720
gene id: 398579:SPEA_RS19720
uniprot id: A8H928
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

398579:SPEA RS01785
gene id: 398579:SPEA_RS01785
uniprot id: A8GZC3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

398579:SPEA RS20705
gene id: 398579:SPEA_RS20705
uniprot id: A8H9L7
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

398579:SPEA RS20025
gene id: 398579:SPEA_RS20025
uniprot id: A8H983
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

398579:SPEA RS07575
gene id: 398579:SPEA_RS07575
uniprot id: A8H2J0
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

398579:SPEA RS20990
gene id: 398579:SPEA_RS20990
uniprot id: A8H9S2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

398579:SPEA RS10015
gene id: 398579:SPEA_RS10015
uniprot id: A8H3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS07955
gene id: 398579:SPEA_RS07955
uniprot id: A8H2P1
names: Similarity
messages: Belongs to the UPF0276 family.

398579:SPEA RS11690
gene id: 398579:SPEA_RS11690
uniprot id: A8H4R2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

398579:SPEA RS17960
gene id: 398579:SPEA_RS17960
uniprot id: A8H837
names: Similarity
messages: Belongs to the peptidase C59 family.

398579:SPEA RS06135
gene id: 398579:SPEA_RS06135
uniprot id: A8H1R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

398579:SPEA RS13275
gene id: 398579:SPEA_RS13275
uniprot id: A8H5J2
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

398579:SPEA RS10950
gene id: 398579:SPEA_RS10950
uniprot id: A8H4C5
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS09510
gene id: 398579:SPEA_RS09510
uniprot id: A8H3J9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS03380
gene id: 398579:SPEA_RS03380
uniprot id: A8H080
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

398579:SPEA RS04345
gene id: 398579:SPEA_RS04345
uniprot id: A8H0R7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

398579:SPEA RS07095
gene id: 398579:SPEA_RS07095
uniprot id: A8H294
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

398579:SPEA RS03510
gene id: 398579:SPEA_RS03510
uniprot id: A8H0A3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

398579:SPEA RS09275
gene id: 398579:SPEA_RS09275
uniprot id: A8H3F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

398579:SPEA RS20710
gene id: 398579:SPEA_RS20710
uniprot id: A8H9L8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS11255
gene id: 398579:SPEA_RS11255
uniprot id: A8H4H6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS13290
gene id: 398579:SPEA_RS13290
uniprot id: A8H5J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS03630
gene id: 398579:SPEA_RS03630
uniprot id: A8H0C7
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS16110
gene id: 398579:SPEA_RS16110
uniprot id: A8H738
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

398579:SPEA RS02985
gene id: 398579:SPEA_RS02985
uniprot id: A8GZZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS18880
gene id: 398579:SPEA_RS18880
uniprot id: A8H8L2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

398579:SPEA RS22095
gene id: 398579:SPEA_RS22095
uniprot id: A8HAD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

398579:SPEA RS04980
gene id: 398579:SPEA_RS04980
uniprot id: A8H143
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

398579:SPEA RS18520
gene id: 398579:SPEA_RS18520
uniprot id: A8H8E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

398579:SPEA RS14135
gene id: 398579:SPEA_RS14135
uniprot id: A8H602
names: Similarity
messages: Belongs to the PspA/IM30 family.

398579:SPEA RS04485
gene id: 398579:SPEA_RS04485
uniprot id: A8H0U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

398579:SPEA RS01280
gene id: 398579:SPEA_RS01280
uniprot id: A8GZ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

398579:SPEA RS06870
gene id: 398579:SPEA_RS06870
uniprot id: A8H252
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

398579:SPEA RS05695
gene id: 398579:SPEA_RS05695
uniprot id: A8H1I3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS18525
gene id: 398579:SPEA_RS18525
uniprot id: A8H8E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

398579:SPEA RS03560
gene id: 398579:SPEA_RS03560
uniprot id: A8H0B3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
messages: Cell inner membrane

398579:SPEA RS12505
gene id: 398579:SPEA_RS12505
uniprot id: A8H545
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

398579:SPEA RS08530
gene id: 398579:SPEA_RS08530
uniprot id: A8H309
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS11680
gene id: 398579:SPEA_RS11680
uniprot id: A8H4R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

398579:SPEA RS09710
gene id: 398579:SPEA_RS09710
uniprot id: A8H3N8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS17595
gene id: 398579:SPEA_RS17595
uniprot id: A8H7W5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS13735
gene id: 398579:SPEA_RS13735
uniprot id: A8H5S2
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.

398579:SPEA RS10620
gene id: 398579:SPEA_RS10620
uniprot id: A8H458
names: Similarity
messages: Belongs to the HypD family.

398579:SPEA RS02210
gene id: 398579:SPEA_RS02210
uniprot id: A8GZK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

398579:SPEA RS21760
gene id: 398579:SPEA_RS21760
uniprot id: A8HA71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

398579:SPEA RS09390
gene id: 398579:SPEA_RS09390
uniprot id: A8H3H5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

398579:SPEA RS01070
gene id: 398579:SPEA_RS01070
uniprot id: A8GYY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

398579:SPEA RS00015
gene id: 398579:SPEA_RS00015
uniprot id: A8GYE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

398579:SPEA RS20320
gene id: 398579:SPEA_RS20320
uniprot id: A8H9E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS04715
gene id: 398579:SPEA_RS04715
uniprot id: A8H0Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

398579:SPEA RS07185
gene id: 398579:SPEA_RS07185
uniprot id: A8H2B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

398579:SPEA RS11025
gene id: 398579:SPEA_RS11025
uniprot id: A8H4D9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

398579:SPEA RS06810
gene id: 398579:SPEA_RS06810
uniprot id: A8H240
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

398579:SPEA RS02550
gene id: 398579:SPEA_RS02550
uniprot id: A8GZR8
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

398579:SPEA RS00550
gene id: 398579:SPEA_RS00550
uniprot id: A8GYP3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

398579:SPEA RS20970
gene id: 398579:SPEA_RS20970
uniprot id: A8H9R8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS13900
gene id: 398579:SPEA_RS13900
uniprot id: A8H5V7
names: Similarity
messages: Belongs to the DEAD box helicase family.

398579:SPEA RS02265
gene id: 398579:SPEA_RS02265
uniprot id: A8GZL2
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

398579:SPEA RS06100
gene id: 398579:SPEA_RS06100
uniprot id: A8H1Q8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

398579:SPEA RS05650
gene id: 398579:SPEA_RS05650
uniprot id: A8H1H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

398579:SPEA RS15320
gene id: 398579:SPEA_RS15320
uniprot id: A8H6N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS13375
gene id: 398579:SPEA_RS13375
uniprot id: A8H5L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

398579:SPEA RS02440
gene id: 398579:SPEA_RS02440
uniprot id: A8GZP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS07650
gene id: 398579:SPEA_RS07650
uniprot id: A8H2J4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS16290
gene id: 398579:SPEA_RS16290
uniprot id: A8H773
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

398579:SPEA RS11445
gene id: 398579:SPEA_RS11445
uniprot id: A8H4L4
names: Similarity
messages: Belongs to the peptidase S16 family.

398579:SPEA RS00785
gene id: 398579:SPEA_RS00785
uniprot id: A8GYU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GSP I family.
messages: Cell inner membrane
messages: Cleaved by prepilin peptidase.
messages: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane
messages: Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus.

398579:SPEA RS08325
gene id: 398579:SPEA_RS08325
uniprot id: A8H2W6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

398579:SPEA RS20930
gene id: 398579:SPEA_RS20930
uniprot id: A8H9R1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS08620
gene id: 398579:SPEA_RS08620
uniprot id: A8H327
names: Similarity
messages: Belongs to the YciI family.

398579:SPEA RS12520
gene id: 398579:SPEA_RS12520
uniprot id: A8H548
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

398579:SPEA RS13660
gene id: 398579:SPEA_RS13660
uniprot id: A8H5Q7
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

398579:SPEA RS02010
gene id: 398579:SPEA_RS02010
uniprot id: A8GZG3
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

398579:SPEA RS16590
gene id: 398579:SPEA_RS16590
uniprot id: A8H7C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS13520
gene id: 398579:SPEA_RS13520
uniprot id: A8H5P1
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

398579:SPEA RS13250
gene id: 398579:SPEA_RS13250
uniprot id: A8H5I7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

398579:SPEA RS14855
gene id: 398579:SPEA_RS14855
uniprot id: A8H6E0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS11090
gene id: 398579:SPEA_RS11090
uniprot id: A8H4E5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS08585
gene id: 398579:SPEA_RS08585
uniprot id: A8H320
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS07580
gene id: 398579:SPEA_RS07580
uniprot id: A8H2J1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS21920
gene id: 398579:SPEA_RS21920
uniprot id: A8HAA3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

398579:SPEA RS08865
gene id: 398579:SPEA_RS08865
uniprot id: A8H374
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

398579:SPEA RS11790
gene id: 398579:SPEA_RS11790
uniprot id: A8H4T1
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

398579:SPEA RS07800
gene id: 398579:SPEA_RS07800
uniprot id: A8H2K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

398579:SPEA RS20500
gene id: 398579:SPEA_RS20500
uniprot id: A8H9H6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

398579:SPEA RS00760
gene id: 398579:SPEA_RS00760
uniprot id: A8GYT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS20125
gene id: 398579:SPEA_RS20125
uniprot id: A8H9A3
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

398579:SPEA RS10840
gene id: 398579:SPEA_RS10840
uniprot id: A8H4A2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS00495
gene id: 398579:SPEA_RS00495
uniprot id: A8GYN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

398579:SPEA RS08150
gene id: 398579:SPEA_RS08150
uniprot id: A8H2T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

398579:SPEA RS01650
gene id: 398579:SPEA_RS01650
uniprot id: A8GZ96
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS01120
gene id: 398579:SPEA_RS01120
uniprot id: A8GYZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

398579:SPEA RS21550
gene id: 398579:SPEA_RS21550
uniprot id: A8HA30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

398579:SPEA RS08575
gene id: 398579:SPEA_RS08575
uniprot id: A8H318
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS00350
gene id: 398579:SPEA_RS00350
uniprot id: A8GYK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

398579:SPEA RS18535
gene id: 398579:SPEA_RS18535
uniprot id: A8H8F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

398579:SPEA RS10400
gene id: 398579:SPEA_RS10400
uniprot id: A8H417
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS09375
gene id: 398579:SPEA_RS09375
uniprot id: A8H3H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS20105
gene id: 398579:SPEA_RS20105
uniprot id: A8H999
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

398579:SPEA RS00025
gene id: 398579:SPEA_RS00025
uniprot id: A8GYE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

398579:SPEA RS11565
gene id: 398579:SPEA_RS11565
uniprot id: A8H4N8
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

398579:SPEA RS12260
gene id: 398579:SPEA_RS12260
uniprot id: A8H509
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS20035
gene id: 398579:SPEA_RS20035
uniprot id: A8H985
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

398579:SPEA RS15355
gene id: 398579:SPEA_RS15355
uniprot id: A8H6P0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS06730
gene id: 398579:SPEA_RS06730
uniprot id: A8H224
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

398579:SPEA RS02430
gene id: 398579:SPEA_RS02430
uniprot id: A8GZP5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS00995
gene id: 398579:SPEA_RS00995
uniprot id: A8GYW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

398579:SPEA RS07085
gene id: 398579:SPEA_RS07085
uniprot id: A8H292
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

398579:SPEA RS18375
gene id: 398579:SPEA_RS18375
uniprot id: A8H8B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

398579:SPEA RS04080
gene id: 398579:SPEA_RS04080
uniprot id: A8H0L5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS18725
gene id: 398579:SPEA_RS18725
uniprot id: A8H8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

398579:SPEA RS10815
gene id: 398579:SPEA_RS10815
uniprot id: A8H497
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

398579:SPEA RS05150
gene id: 398579:SPEA_RS05150
uniprot id: A8H175
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

398579:SPEA RS20400
gene id: 398579:SPEA_RS20400
uniprot id: A8H9F6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS10315
gene id: 398579:SPEA_RS10315
uniprot id: A8H400
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

398579:SPEA RS10710
gene id: 398579:SPEA_RS10710
uniprot id: A8H476
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

398579:SPEA RS04555
gene id: 398579:SPEA_RS04555
uniprot id: A8H0W0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

398579:SPEA RS00865
gene id: 398579:SPEA_RS00865
uniprot id: A8GYV7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

398579:SPEA RS10875
gene id: 398579:SPEA_RS10875
uniprot id: A8H4A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

398579:SPEA RS15920
gene id: 398579:SPEA_RS15920
uniprot id: A8H700
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

398579:SPEA RS05870
gene id: 398579:SPEA_RS05870
uniprot id: A8H1L2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

398579:SPEA RS15700
gene id: 398579:SPEA_RS15700
uniprot id: A8H6V6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Xni family.
messages: Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.
messages: Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.
messages: Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.

398579:SPEA RS16250
gene id: 398579:SPEA_RS16250
uniprot id: A8H764
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

398579:SPEA RS03135
gene id: 398579:SPEA_RS03135
uniprot id: A8H030
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS00775
gene id: 398579:SPEA_RS00775
uniprot id: A8GYT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS19120
gene id: 398579:SPEA_RS19120
uniprot id: A8H8Q9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.

398579:SPEA RS14710
gene id: 398579:SPEA_RS14710
uniprot id: A8H6B3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

398579:SPEA RS05580
gene id: 398579:SPEA_RS05580
uniprot id: A8H1G0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

398579:SPEA RS06210
gene id: 398579:SPEA_RS06210
uniprot id: A8H1S9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

398579:SPEA RS01695
gene id: 398579:SPEA_RS01695
uniprot id: A8GZA5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS19140
gene id: 398579:SPEA_RS19140
uniprot id: A8H8R3
names: Similarity
messages: Belongs to the UPF0251 family.

398579:SPEA RS07780
gene id: 398579:SPEA_RS07780
uniprot id: A8H2K5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

398579:SPEA RS08030
gene id: 398579:SPEA_RS08030
uniprot id: A8H2Q7
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

398579:SPEA RS21455
gene id: 398579:SPEA_RS21455
uniprot id: A8HA13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

398579:SPEA RS03570
gene id: 398579:SPEA_RS03570
uniprot id: A8H0B5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

398579:SPEA RS16445
gene id: 398579:SPEA_RS16445
uniprot id: A8H7A4
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

398579:SPEA RS09605
gene id: 398579:SPEA_RS09605
uniprot id: A8H3L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

398579:SPEA RS17750
gene id: 398579:SPEA_RS17750
uniprot id: A8H7Z5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

398579:SPEA RS07790
gene id: 398579:SPEA_RS07790
uniprot id: A8H2K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

398579:SPEA RS05140
gene id: 398579:SPEA_RS05140
uniprot id: A8H173
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS04545
gene id: 398579:SPEA_RS04545
uniprot id: A8H0V8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

398579:SPEA RS12770
gene id: 398579:SPEA_RS12770
uniprot id: A8H593
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

398579:SPEA RS00180
gene id: 398579:SPEA_RS00180
uniprot id: A8GYH5
names: Similarity
messages: Belongs to the DprA/Smf family.

398579:SPEA RS08875
gene id: 398579:SPEA_RS08875
uniprot id: A8H376
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

398579:SPEA RS04395
gene id: 398579:SPEA_RS04395
uniprot id: A8H0S7
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

398579:SPEA RS07000
gene id: 398579:SPEA_RS07000
uniprot id: A8H276
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

398579:SPEA RS06845
gene id: 398579:SPEA_RS06845
uniprot id: A8H247
names: Similarity
messages: Belongs to the YfgM family.

398579:SPEA RS01850
gene id: 398579:SPEA_RS01850
uniprot id: A8GZD5
names: Caution
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS22045
gene id: 398579:SPEA_RS22045
uniprot id: A8HAC8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

398579:SPEA RS07965
gene id: 398579:SPEA_RS07965
uniprot id: A8H2P4
names: Subcellular Location Annotation
messages: Cell inner membrane

398579:SPEA RS05655
gene id: 398579:SPEA_RS05655
uniprot id: A8H1H5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

398579:SPEA RS22290
gene id: 398579:SPEA_RS22290
uniprot id: A8HAH1
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

398579:SPEA RS13625
gene id: 398579:SPEA_RS13625
uniprot id: A8H5Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

398579:SPEA RS06670
gene id: 398579:SPEA_RS06670
uniprot id: A8H212
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

398579:SPEA RS04160
gene id: 398579:SPEA_RS04160
uniprot id: A8H0N1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

398579:SPEA RS21980
gene id: 398579:SPEA_RS21980
uniprot id: A8HAB5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS06195
gene id: 398579:SPEA_RS06195
uniprot id: A8H1S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

398579:SPEA RS04945
gene id: 398579:SPEA_RS04945
uniprot id: A8H136
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

398579:SPEA RS18590
gene id: 398579:SPEA_RS18590
uniprot id: A8H8G1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

398579:SPEA RS17420
gene id: 398579:SPEA_RS17420
uniprot id: A8H7S9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

398579:SPEA RS14320
gene id: 398579:SPEA_RS14320
uniprot id: A8H636
names: Similarity
messages: Belongs to the CdaR family.

398579:SPEA RS06060
gene id: 398579:SPEA_RS06060
uniprot id: A8H1Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS03415
gene id: 398579:SPEA_RS03415
uniprot id: A8H086
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

398579:SPEA RS14225
gene id: 398579:SPEA_RS14225
uniprot id: A8H617
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS06470
gene id: 398579:SPEA_RS06470
uniprot id: A8H1X1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

398579:SPEA RS05730
gene id: 398579:SPEA_RS05730
uniprot id: A8H1J0
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

398579:SPEA RS20150
gene id: 398579:SPEA_RS20150
uniprot id: A8H9A8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

398579:SPEA RS08050
gene id: 398579:SPEA_RS08050
uniprot id: A8H2R1
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

398579:SPEA RS15120
gene id: 398579:SPEA_RS15120
uniprot id: A8H6J3
names: Similarity
messages: Belongs to the universal stress protein A family.

398579:SPEA RS20895
gene id: 398579:SPEA_RS20895
uniprot id: A8H9Q4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

398579:SPEA RS22340
gene id: 398579:SPEA_RS22340
uniprot id: A8HAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

398579:SPEA RS13870
gene id: 398579:SPEA_RS13870
uniprot id: A8H5V1
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

398579:SPEA RS12400
gene id: 398579:SPEA_RS12400
uniprot id: A8H532
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

398579:SPEA RS02045
gene id: 398579:SPEA_RS02045
uniprot id: A8GZH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

398579:SPEA RS04765
gene id: 398579:SPEA_RS04765
uniprot id: A8H100
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

398579:SPEA RS01360
gene id: 398579:SPEA_RS01360
uniprot id: A8GZ38
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS02215
gene id: 398579:SPEA_RS02215
uniprot id: A8GZK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

398579:SPEA RS19055
gene id: 398579:SPEA_RS19055
uniprot id: A8H8P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

398579:SPEA RS14525
gene id: 398579:SPEA_RS14525
uniprot id: A8H677
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS05910
gene id: 398579:SPEA_RS05910
uniprot id: A8H1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

398579:SPEA RS07040
gene id: 398579:SPEA_RS07040
uniprot id: A8H284
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

398579:SPEA RS12635
gene id: 398579:SPEA_RS12635
uniprot id: A8H571
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS16955
gene id: 398579:SPEA_RS16955
uniprot id: A8H7I7
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

398579:SPEA RS10880
gene id: 398579:SPEA_RS10880
uniprot id: A8H4B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

398579:SPEA RS07935
gene id: 398579:SPEA_RS07935
uniprot id: A8H2N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS04795
gene id: 398579:SPEA_RS04795
uniprot id: A8H106
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

398579:SPEA RS11505
gene id: 398579:SPEA_RS11505
uniprot id: A8H4M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS05545
gene id: 398579:SPEA_RS05545
uniprot id: A8H1F3
names: Similarity
messages: Belongs to the TrpR family.

398579:SPEA RS19335
gene id: 398579:SPEA_RS19335
uniprot id: A8H8V0
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

398579:SPEA RS20175
gene id: 398579:SPEA_RS20175
uniprot id: A8H9B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoid occlusion factor SlmA family.
messages: Homodimer. Interacts with FtsZ.
messages: Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
messages: nucleoid

398579:SPEA RS10700
gene id: 398579:SPEA_RS10700
uniprot id: A8H474
names: Cofactor
messages: Can also use Mn(2+) ion.

398579:SPEA RS13860
gene id: 398579:SPEA_RS13860
uniprot id: A8H5U9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

398579:SPEA RS06010
gene id: 398579:SPEA_RS06010
uniprot id: A8H1P0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS16345
gene id: 398579:SPEA_RS16345
uniprot id: A8H784
names: Similarity
messages: Belongs to the BolA/IbaG family.

398579:SPEA RS06815
gene id: 398579:SPEA_RS06815
uniprot id: A8H241
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS19115
gene id: 398579:SPEA_RS19115
uniprot id: A8H8Q8
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS22305
gene id: 398579:SPEA_RS22305
uniprot id: A8HAH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

398579:SPEA RS05705
gene id: 398579:SPEA_RS05705
uniprot id: A8H1I5
names: Similarity
messages: Belongs to the P(II) protein family.

398579:SPEA RS18700
gene id: 398579:SPEA_RS18700
uniprot id: A8H8H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

398579:SPEA RS03325
gene id: 398579:SPEA_RS03325
uniprot id: A8H069
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS14430
gene id: 398579:SPEA_RS14430
uniprot id: A8H657
names: Similarity
messages: Belongs to the transglycosylase Slt family.

398579:SPEA RS21215
gene id: 398579:SPEA_RS21215
uniprot id: A8H9W6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS02140
gene id: 398579:SPEA_RS02140
uniprot id: A8GZJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

398579:SPEA RS06215
gene id: 398579:SPEA_RS06215
uniprot id: A8H1T0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

398579:SPEA RS04775
gene id: 398579:SPEA_RS04775
uniprot id: A8H102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

398579:SPEA RS11640
gene id: 398579:SPEA_RS11640
uniprot id: A8H4Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

398579:SPEA RS14080
gene id: 398579:SPEA_RS14080
uniprot id: A8H5Z2
names: Similarity
messages: Belongs to the UPF0319 family.

398579:SPEA RS07980
gene id: 398579:SPEA_RS07980
uniprot id: A8H2P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

398579:SPEA RS07975
gene id: 398579:SPEA_RS07975
uniprot id: A8H2P6
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

398579:SPEA RS10615
gene id: 398579:SPEA_RS10615
uniprot id: A8H457
names: Similarity
messages: Belongs to the HypE family.

398579:SPEA RS05605
gene id: 398579:SPEA_RS05605
uniprot id: A8H1G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS00685
gene id: 398579:SPEA_RS00685
uniprot id: A8GYS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

398579:SPEA RS16790
gene id: 398579:SPEA_RS16790
uniprot id: A8H7F3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS17435
gene id: 398579:SPEA_RS17435
uniprot id: A8H7T2
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

398579:SPEA RS16145
gene id: 398579:SPEA_RS16145
uniprot id: A8H743
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS18315
gene id: 398579:SPEA_RS18315
uniprot id: A8H8A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

398579:SPEA RS02015
gene id: 398579:SPEA_RS02015
uniprot id: A8GZG4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

398579:SPEA RS15645
gene id: 398579:SPEA_RS15645
uniprot id: A8H6U5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

398579:SPEA RS03915
gene id: 398579:SPEA_RS03915
uniprot id: A8H0I2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

398579:SPEA RS13600
gene id: 398579:SPEA_RS13600
uniprot id: A8H5P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

398579:SPEA RS03935
gene id: 398579:SPEA_RS03935
uniprot id: A8H0I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

398579:SPEA RS02200
gene id: 398579:SPEA_RS02200
uniprot id: A8GZJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

398579:SPEA RS16945
gene id: 398579:SPEA_RS16945
uniprot id: A8H7I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS03695
gene id: 398579:SPEA_RS03695
uniprot id: A8H0E0
names: Similarity
messages: Belongs to the peptidase M17 family.

398579:SPEA RS09430
gene id: 398579:SPEA_RS09430
uniprot id: A8H3I3
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-54 and Arg-57) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

398579:SPEA RS17295
gene id: 398579:SPEA_RS17295
uniprot id: A8H7Q5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

398579:SPEA RS11210
gene id: 398579:SPEA_RS11210
uniprot id: A8H4G7
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

398579:SPEA RS16405
gene id: 398579:SPEA_RS16405
uniprot id: A8H796
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

398579:SPEA RS10645
gene id: 398579:SPEA_RS10645
uniprot id: A8H463
names: Similarity
messages: Belongs to the peptidase A31 family.

398579:SPEA RS09450
gene id: 398579:SPEA_RS09450
uniprot id: A8H3I7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

398579:SPEA RS04955
gene id: 398579:SPEA_RS04955
uniprot id: A8H138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

398579:SPEA RS04470
gene id: 398579:SPEA_RS04470
uniprot id: A8H0U3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

398579:SPEA RS06725
gene id: 398579:SPEA_RS06725
uniprot id: A8H223
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

398579:SPEA RS16105
gene id: 398579:SPEA_RS16105
uniprot id: A8H737
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

398579:SPEA RS22110
gene id: 398579:SPEA_RS22110
uniprot id: A8HAE0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

398579:SPEA RS06455
gene id: 398579:SPEA_RS06455
uniprot id: A8H1W8
names: Similarity
messages: Belongs to the cytochrome c-552 family.

398579:SPEA RS02505
gene id: 398579:SPEA_RS02505
uniprot id: A8GZQ9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

398579:SPEA RS19085
gene id: 398579:SPEA_RS19085
uniprot id: A8H8Q2
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS22255
gene id: 398579:SPEA_RS22255
uniprot id: A8HAG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

398579:SPEA RS12535
gene id: 398579:SPEA_RS12535
uniprot id: A8H551
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

398579:SPEA RS22050
gene id: 398579:SPEA_RS22050
uniprot id: A8HAC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

398579:SPEA RS21195
gene id: 398579:SPEA_RS21195
uniprot id: A8H9W2
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

398579:SPEA RS10865
gene id: 398579:SPEA_RS10865
uniprot id: A8H4A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

398579:SPEA RS04480
gene id: 398579:SPEA_RS04480
uniprot id: A8H0U5
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

398579:SPEA RS14230
gene id: 398579:SPEA_RS14230
uniprot id: A8H618
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

398579:SPEA RS19310
gene id: 398579:SPEA_RS19310
uniprot id: A8H8U6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS20335
gene id: 398579:SPEA_RS20335
uniprot id: A8H9E4
names: Similarity
messages: Belongs to the group II decarboxylase family.

398579:SPEA RS22400
gene id: 398579:SPEA_RS22400
uniprot id: A8H3P4
names: Subcellular Location Annotation
messages: Cell surface

398579:SPEA RS01750
gene id: 398579:SPEA_RS01750
uniprot id: A8GZB6
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

398579:SPEA RS20975
gene id: 398579:SPEA_RS20975
uniprot id: A8H9R9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Cell inner membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

398579:SPEA RS13260
gene id: 398579:SPEA_RS13260
uniprot id: A8H5I9
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

398579:SPEA RS04000
gene id: 398579:SPEA_RS04000
uniprot id: A8H0J9
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

398579:SPEA RS18850
gene id: 398579:SPEA_RS18850
uniprot id: A8H8K7
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

398579:SPEA RS17570
gene id: 398579:SPEA_RS17570
uniprot id: A8H7W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

398579:SPEA RS07200
gene id: 398579:SPEA_RS07200
uniprot id: A8H2B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

398579:SPEA RS06880
gene id: 398579:SPEA_RS06880
uniprot id: A8H254
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

398579:SPEA RS08355
gene id: 398579:SPEA_RS08355
uniprot id: A8H2X5
names: Function
names: Similarity
messages: Belongs to the TrpC family.
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

398579:SPEA RS16055
gene id: 398579:SPEA_RS16055
uniprot id: A8H727
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.
messages: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

398579:SPEA RS14780
gene id: 398579:SPEA_RS14780
uniprot id: A8H6C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

398579:SPEA RS10045
gene id: 398579:SPEA_RS10045
uniprot id: A8H3V3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

398579:SPEA RS17910
gene id: 398579:SPEA_RS17910
uniprot id: A8H827
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

398579:SPEA RS12845
gene id: 398579:SPEA_RS12845
uniprot id: A8H5A8
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.
messages: Membrane

398579:SPEA RS21190
gene id: 398579:SPEA_RS21190
uniprot id: A8H9W1
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS15075
gene id: 398579:SPEA_RS15075
uniprot id: A8H6I4
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS19010
gene id: 398579:SPEA_RS19010
uniprot id: A8H8N8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

398579:SPEA RS16620
gene id: 398579:SPEA_RS16620
uniprot id: A8H7C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

398579:SPEA RS15915
gene id: 398579:SPEA_RS15915
uniprot id: A8H6Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

398579:SPEA RS05330
gene id: 398579:SPEA_RS05330
uniprot id: A8H1B1
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

398579:SPEA RS09835
gene id: 398579:SPEA_RS09835
uniprot id: A8H3R0
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

398579:SPEA RS01055
gene id: 398579:SPEA_RS01055
uniprot id: A8GYY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

398579:SPEA RS03490
gene id: 398579:SPEA_RS03490
uniprot id: A8H099
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

398579:SPEA RS18760
gene id: 398579:SPEA_RS18760
uniprot id: A8H8I9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

398579:SPEA RS08080
gene id: 398579:SPEA_RS08080
uniprot id: A8H2R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

398579:SPEA RS08265
gene id: 398579:SPEA_RS08265
uniprot id: A8H2V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

398579:SPEA RS10650
gene id: 398579:SPEA_RS10650
uniprot id: A8H464
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

398579:SPEA RS08840
gene id: 398579:SPEA_RS08840
uniprot id: A8H369
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

398579:SPEA RS01845
gene id: 398579:SPEA_RS01845
uniprot id: A8GZD4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS05195
gene id: 398579:SPEA_RS05195
uniprot id: A8H184
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS09770
gene id: 398579:SPEA_RS09770
uniprot id: A8H3P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS03845
gene id: 398579:SPEA_RS03845
uniprot id: A8H0G8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS00955
gene id: 398579:SPEA_RS00955
uniprot id: A8GYW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

398579:SPEA RS08760
gene id: 398579:SPEA_RS08760
uniprot id: A8H352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

398579:SPEA RS02585
gene id: 398579:SPEA_RS02585
uniprot id: A8GZS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

398579:SPEA RS15195
gene id: 398579:SPEA_RS15195
uniprot id: A8H6K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

398579:SPEA RS13955
gene id: 398579:SPEA_RS13955
uniprot id: A8H5W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

398579:SPEA RS07860
gene id: 398579:SPEA_RS07860
uniprot id: A8H2M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS09055
gene id: 398579:SPEA_RS09055
uniprot id: A8H3A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

398579:SPEA RS10725
gene id: 398579:SPEA_RS10725
uniprot id: A8H479
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

398579:SPEA RS05265
gene id: 398579:SPEA_RS05265
uniprot id: A8H198
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

398579:SPEA RS01080
gene id: 398579:SPEA_RS01080
uniprot id: A8GYZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

398579:SPEA RS06065
gene id: 398579:SPEA_RS06065
uniprot id: A8H1Q1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

398579:SPEA RS02390
gene id: 398579:SPEA_RS02390
uniprot id: A8GZN7
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

398579:SPEA RS05970
gene id: 398579:SPEA_RS05970
uniprot id: A8H1N2
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

398579:SPEA RS07485
gene id: 398579:SPEA_RS07485
uniprot id: A8H2H2
names: Subcellular Location Annotation
messages: Cell inner membrane

398579:SPEA RS17130
gene id: 398579:SPEA_RS17130
uniprot id: A8H7M2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

398579:SPEA RS12910
gene id: 398579:SPEA_RS12910
uniprot id: A8H5C1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Multifunctional regulator of fatty acid metabolism.

398579:SPEA RS13200
gene id: 398579:SPEA_RS13200
uniprot id: A8H5H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

398579:SPEA RS15070
gene id: 398579:SPEA_RS15070
uniprot id: A8H6I3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

398579:SPEA RS09545
gene id: 398579:SPEA_RS09545
uniprot id: A8H3K6
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

398579:SPEA RS14060
gene id: 398579:SPEA_RS14060
uniprot id: A8H5Y8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

398579:SPEA RS07130
gene id: 398579:SPEA_RS07130
uniprot id: A8H2A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

398579:SPEA RS18680
gene id: 398579:SPEA_RS18680
uniprot id: A8H8H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

398579:SPEA RS13395
gene id: 398579:SPEA_RS13395
uniprot id: A8H5L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

398579:SPEA RS11860
gene id: 398579:SPEA_RS11860
uniprot id: A8H4U3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

398579:SPEA RS08000
gene id: 398579:SPEA_RS08000
uniprot id: A8H2Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS02555
gene id: 398579:SPEA_RS02555
uniprot id: A8GZR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS10830
gene id: 398579:SPEA_RS10830
uniprot id: A8H4A0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

398579:SPEA RS09740
gene id: 398579:SPEA_RS09740
uniprot id: A8H3P3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

398579:SPEA RS17685
gene id: 398579:SPEA_RS17685
uniprot id: A8H7Y3
names: Similarity
messages: Belongs to the universal stress protein A family.

398579:SPEA RS11700
gene id: 398579:SPEA_RS11700
uniprot id: A8H4R4
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

398579:SPEA RS07890
gene id: 398579:SPEA_RS07890
uniprot id: A8H2M7
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

398579:SPEA RS07515
gene id: 398579:SPEA_RS07515
uniprot id: A8H2H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

398579:SPEA RS13980
gene id: 398579:SPEA_RS13980
uniprot id: A8H5X2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS05885
gene id: 398579:SPEA_RS05885
uniprot id: A8H1L5
names: Similarity
messages: Belongs to the YggT family.

398579:SPEA RS08290
gene id: 398579:SPEA_RS08290
uniprot id: A8H2V9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

398579:SPEA RS02380
gene id: 398579:SPEA_RS02380
uniprot id: A8GZN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

398579:SPEA RS11205
gene id: 398579:SPEA_RS11205
uniprot id: A8H4G6
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

398579:SPEA RS19170
gene id: 398579:SPEA_RS19170
uniprot id: A8H8R9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

398579:SPEA RS14105
gene id: 398579:SPEA_RS14105
uniprot id: A8H5Z6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS07140
gene id: 398579:SPEA_RS07140
uniprot id: A8H2A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

398579:SPEA RS11075
gene id: 398579:SPEA_RS11075
uniprot id: A8H4E2
names: Similarity
messages: Belongs to the DsrF/TusC family.

398579:SPEA RS13190
gene id: 398579:SPEA_RS13190
uniprot id: A8H5H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

398579:SPEA RS05410
gene id: 398579:SPEA_RS05410
uniprot id: A8H1C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

398579:SPEA RS20685
gene id: 398579:SPEA_RS20685
uniprot id: A8H9L3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS19600
gene id: 398579:SPEA_RS19600
uniprot id: A8H904
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS19020
gene id: 398579:SPEA_RS19020
uniprot id: A8H8P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

398579:SPEA RS02135
gene id: 398579:SPEA_RS02135
uniprot id: A8GZI9
names: Similarity
messages: Belongs to the thioredoxin family.

398579:SPEA RS15080
gene id: 398579:SPEA_RS15080
uniprot id: A8H6I5
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

398579:SPEA RS21850
gene id: 398579:SPEA_RS21850
uniprot id: A8HA89
names: Similarity
messages: Belongs to the RutC family.

398579:SPEA RS02295
gene id: 398579:SPEA_RS02295
uniprot id: A8GZL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS02000
gene id: 398579:SPEA_RS02000
uniprot id: A8GZG1
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS10390
gene id: 398579:SPEA_RS10390
uniprot id: A8H415
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

398579:SPEA RS10135
gene id: 398579:SPEA_RS10135
uniprot id: A8H3X1
names: Similarity
messages: Belongs to the peptidase M1 family.

398579:SPEA RS06940
gene id: 398579:SPEA_RS06940
uniprot id: A8H265
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS13010
gene id: 398579:SPEA_RS13010
uniprot id: A8H5E0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

398579:SPEA RS09850
gene id: 398579:SPEA_RS09850
uniprot id: A8H3R3
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

398579:SPEA RS00505
gene id: 398579:SPEA_RS00505
uniprot id: A8GYN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

398579:SPEA RS01045
gene id: 398579:SPEA_RS01045
uniprot id: A8GYY4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

398579:SPEA RS15345
gene id: 398579:SPEA_RS15345
uniprot id: A8H6N8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

398579:SPEA RS19265
gene id: 398579:SPEA_RS19265
uniprot id: A8H8T7
names: Similarity
messages: Belongs to the UPF0053 family.

398579:SPEA RS20095
gene id: 398579:SPEA_RS20095
uniprot id: A8H997
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS21970
gene id: 398579:SPEA_RS21970
uniprot id: A8HAB3
names: Similarity
messages: Belongs to the peptidase S33 family.

398579:SPEA RS14510
gene id: 398579:SPEA_RS14510
uniprot id: A8H674
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS04605
gene id: 398579:SPEA_RS04605
uniprot id: A8H0X0
names: Similarity
messages: Belongs to the MipA/OmpV family.

398579:SPEA RS03140
gene id: 398579:SPEA_RS03140
uniprot id: A8H031
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS04450
gene id: 398579:SPEA_RS04450
uniprot id: A8H0T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

398579:SPEA RS21480
gene id: 398579:SPEA_RS21480
uniprot id: A8HA18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

398579:SPEA RS00965
gene id: 398579:SPEA_RS00965
uniprot id: A8GYW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

398579:SPEA RS09280
gene id: 398579:SPEA_RS09280
uniprot id: A8H3F2
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

398579:SPEA RS14700
gene id: 398579:SPEA_RS14700
uniprot id: A8H6B1
names: Similarity
messages: Belongs to the HIBADH-related family.

398579:SPEA RS01330
gene id: 398579:SPEA_RS01330
uniprot id: A8GZ32
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

398579:SPEA RS05555
gene id: 398579:SPEA_RS05555
uniprot id: A8H1F5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

398579:SPEA RS03620
gene id: 398579:SPEA_RS03620
uniprot id: A8H0C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

398579:SPEA RS10125
gene id: 398579:SPEA_RS10125
uniprot id: A8H3W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ProQ family.
messages: Cytoplasm
messages: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.

398579:SPEA RS22000
gene id: 398579:SPEA_RS22000
uniprot id: A8HAB9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

398579:SPEA RS01880
gene id: 398579:SPEA_RS01880
uniprot id: A8GZE1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

398579:SPEA RS09040
gene id: 398579:SPEA_RS09040
uniprot id: A8H3A5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS00100
gene id: 398579:SPEA_RS00100
uniprot id: A8GYG0
names: Function
names: Similarity
names: Subunit
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).
messages: In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.

398579:SPEA RS18330
gene id: 398579:SPEA_RS18330
uniprot id: A8H8A8
names: Similarity
messages: Belongs to the PspA/IM30 family.

398579:SPEA RS08805
gene id: 398579:SPEA_RS08805
uniprot id: A8H361
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

398579:SPEA RS18815
gene id: 398579:SPEA_RS18815
uniprot id: A8H8K0
names: Cofactor
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN covalently per subunit.

398579:SPEA RS18900
gene id: 398579:SPEA_RS18900
uniprot id: A8H8L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

398579:SPEA RS01910
gene id: 398579:SPEA_RS01910
uniprot id: A8GZE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

398579:SPEA RS21695
gene id: 398579:SPEA_RS21695
uniprot id: A8HA58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

398579:SPEA RS21610
gene id: 398579:SPEA_RS21610
uniprot id: A8HA42
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

398579:SPEA RS03670
gene id: 398579:SPEA_RS03670
uniprot id: A8H0D5
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

398579:SPEA RS11110
gene id: 398579:SPEA_RS11110
uniprot id: A8H4E8
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS22025
gene id: 398579:SPEA_RS22025
uniprot id: A8HAC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS03790
gene id: 398579:SPEA_RS03790
uniprot id: A8H0F9
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS18345
gene id: 398579:SPEA_RS18345
uniprot id: A8H8B1
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS12515
gene id: 398579:SPEA_RS12515
uniprot id: A8H547
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

398579:SPEA RS19860
gene id: 398579:SPEA_RS19860
uniprot id: A8H956
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

398579:SPEA RS05365
gene id: 398579:SPEA_RS05365
uniprot id: A8H1B8
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

398579:SPEA RS06485
gene id: 398579:SPEA_RS06485
uniprot id: A8H1X4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS00750
gene id: 398579:SPEA_RS00750
uniprot id: A8GYT4
names: Similarity
messages: Belongs to the HSP15 family.

398579:SPEA RS01250
gene id: 398579:SPEA_RS01250
uniprot id: A8GZ16
names: Function
names: Similarity
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

398579:SPEA RS15220
gene id: 398579:SPEA_RS15220
uniprot id: A8H6L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

398579:SPEA RS07435
gene id: 398579:SPEA_RS07435
uniprot id: A8H2G2
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

398579:SPEA RS20005
gene id: 398579:SPEA_RS20005
uniprot id: A8H979
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

398579:SPEA RS08300
gene id: 398579:SPEA_RS08300
uniprot id: A8H2W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS04940
gene id: 398579:SPEA_RS04940
uniprot id: A8H135
names: Similarity
messages: Belongs to the glutamine synthetase family.

398579:SPEA RS08095
gene id: 398579:SPEA_RS08095
uniprot id: A8H2S0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS03460
gene id: 398579:SPEA_RS03460
uniprot id: A8H095
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS10385
gene id: 398579:SPEA_RS10385
uniprot id: A8H414
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS01025
gene id: 398579:SPEA_RS01025
uniprot id: A8GYY0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

398579:SPEA RS00710
gene id: 398579:SPEA_RS00710
uniprot id: A8GYS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

398579:SPEA RS01100
gene id: 398579:SPEA_RS01100
uniprot id: A8GYZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

398579:SPEA RS16305
gene id: 398579:SPEA_RS16305
uniprot id: A8H776
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

398579:SPEA RS00695
gene id: 398579:SPEA_RS00695
uniprot id: A8GYS3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

398579:SPEA RS02435
gene id: 398579:SPEA_RS02435
uniprot id: A8GZP6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS10085
gene id: 398579:SPEA_RS10085
uniprot id: A8H3W1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

398579:SPEA RS15245
gene id: 398579:SPEA_RS15245
uniprot id: A8H6L8
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

398579:SPEA RS15180
gene id: 398579:SPEA_RS15180
uniprot id: A8H6K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

398579:SPEA RS01030
gene id: 398579:SPEA_RS01030
uniprot id: A8GYY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

398579:SPEA RS17930
gene id: 398579:SPEA_RS17930
uniprot id: A8H831
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

398579:SPEA RS04770
gene id: 398579:SPEA_RS04770
uniprot id: A8H101
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

398579:SPEA RS01270
gene id: 398579:SPEA_RS01270
uniprot id: A8GZ20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS13665
gene id: 398579:SPEA_RS13665
uniprot id: A8H5Q8
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS18400
gene id: 398579:SPEA_RS18400
uniprot id: A8H8C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlE subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

398579:SPEA RS17870
gene id: 398579:SPEA_RS17870
uniprot id: A8H819
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.

398579:SPEA RS10005
gene id: 398579:SPEA_RS10005
uniprot id: A8H3U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

398579:SPEA RS21675
gene id: 398579:SPEA_RS21675
uniprot id: A8HA54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

398579:SPEA RS02195
gene id: 398579:SPEA_RS02195
uniprot id: A8GZJ8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

398579:SPEA RS12315
gene id: 398579:SPEA_RS12315
uniprot id: A8H520
names: Similarity
messages: Belongs to the pyruvate kinase family.

398579:SPEA RS01265
gene id: 398579:SPEA_RS01265
uniprot id: A8GZ19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

398579:SPEA RS18990
gene id: 398579:SPEA_RS18990
uniprot id: A8H8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

398579:SPEA RS11915
gene id: 398579:SPEA_RS11915
uniprot id: A8H4V4
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS08370
gene id: 398579:SPEA_RS08370
uniprot id: A8H2X8
names: Cofactor
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.

398579:SPEA RS20115
gene id: 398579:SPEA_RS20115
uniprot id: A8H9A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

398579:SPEA RS03430
gene id: 398579:SPEA_RS03430
uniprot id: A8H089
names: Similarity
messages: Belongs to the MipA/OmpV family.

398579:SPEA RS16930
gene id: 398579:SPEA_RS16930
uniprot id: A8H7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

398579:SPEA RS00375
gene id: 398579:SPEA_RS00375
uniprot id: A8GYK8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

398579:SPEA RS21025
gene id: 398579:SPEA_RS21025
uniprot id: A8H9S8
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS22235
gene id: 398579:SPEA_RS22235
uniprot id: A8HAG0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

398579:SPEA RS19715
gene id: 398579:SPEA_RS19715
uniprot id: A8H927
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

398579:SPEA RS21205
gene id: 398579:SPEA_RS21205
uniprot id: A8H9W4
names: Function
names: Similarity
messages: Belongs to the ETF-QO/FixC family.
messages: Part of an electron transfer system.

398579:SPEA RS12125
gene id: 398579:SPEA_RS12125
uniprot id: A8H4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

398579:SPEA RS17760
gene id: 398579:SPEA_RS17760
uniprot id: A8H7Z7
names: Subcellular Location Annotation
messages: Periplasm

398579:SPEA RS11630
gene id: 398579:SPEA_RS11630
uniprot id: A8H4Q0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

398579:SPEA RS21495
gene id: 398579:SPEA_RS21495
uniprot id: A8HA21
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

398579:SPEA RS08930
gene id: 398579:SPEA_RS08930
uniprot id: A8H387
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

398579:SPEA RS12950
gene id: 398579:SPEA_RS12950
uniprot id: A8H5C9
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

398579:SPEA RS07845
gene id: 398579:SPEA_RS07845
uniprot id: A8H2L8
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS21210
gene id: 398579:SPEA_RS21210
uniprot id: A8H9W5
names: Function
messages: Could be a 3Fe-4S cluster-containing protein.

398579:SPEA RS00650
gene id: 398579:SPEA_RS00650
uniprot id: A8GYR4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

398579:SPEA RS13130
gene id: 398579:SPEA_RS13130
uniprot id: A8H5G5
names: Similarity
messages: Belongs to the UPF0502 family.

398579:SPEA RS18495
gene id: 398579:SPEA_RS18495
uniprot id: A8H8E2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

398579:SPEA RS13425
gene id: 398579:SPEA_RS13425
uniprot id: A8H5M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell inner membrane
messages: Cytoplasm

398579:SPEA RS07465
gene id: 398579:SPEA_RS07465
uniprot id: A8H2G8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

398579:SPEA RS15755
gene id: 398579:SPEA_RS15755
uniprot id: A8H6W7
names: Similarity
messages: Belongs to the MotB family.

398579:SPEA RS03990
gene id: 398579:SPEA_RS03990
uniprot id: A8H0J7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS05815
gene id: 398579:SPEA_RS05815
uniprot id: A8H1K1
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

398579:SPEA RS00405
gene id: 398579:SPEA_RS00405
uniprot id: A8GYL4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

398579:SPEA RS16860
gene id: 398579:SPEA_RS16860
uniprot id: A8H7G7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

398579:SPEA RS06095
gene id: 398579:SPEA_RS06095
uniprot id: A8H1Q7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

398579:SPEA RS12500
gene id: 398579:SPEA_RS12500
uniprot id: A8H544
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS20890
gene id: 398579:SPEA_RS20890
uniprot id: A8H9Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

398579:SPEA RS22350
gene id: 398579:SPEA_RS22350
uniprot id: A8HAI3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

398579:SPEA RS08140
gene id: 398579:SPEA_RS08140
uniprot id: A8H2S9
names: Similarity
messages: Belongs to the acylphosphatase family.

398579:SPEA RS06925
gene id: 398579:SPEA_RS06925
uniprot id: A8H262
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

398579:SPEA RS15580
gene id: 398579:SPEA_RS15580
uniprot id: A8H6T3
names: Similarity
messages: Belongs to the group II decarboxylase family.

398579:SPEA RS11175
gene id: 398579:SPEA_RS11175
uniprot id: A8H4G0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS08045
gene id: 398579:SPEA_RS08045
uniprot id: A8H2R0
names: Similarity
messages: Belongs to the DapA family.

398579:SPEA RS08790
gene id: 398579:SPEA_RS08790
uniprot id: A8H358
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

398579:SPEA RS02330
gene id: 398579:SPEA_RS02330
uniprot id: A8GZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS03390
gene id: 398579:SPEA_RS03390
uniprot id: A8H081
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS14575
gene id: 398579:SPEA_RS14575
uniprot id: A8H687
names: Subcellular Location Annotation
messages: Secreted

398579:SPEA RS11560
gene id: 398579:SPEA_RS11560
uniprot id: A8H4N7
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

398579:SPEA RS18875
gene id: 398579:SPEA_RS18875
uniprot id: A8H8L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

398579:SPEA RS04250
gene id: 398579:SPEA_RS04250
uniprot id: A8H0P9
names: Similarity
messages: Belongs to the UPF0597 family.

398579:SPEA RS20390
gene id: 398579:SPEA_RS20390
uniprot id: A8H9F4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS09830
gene id: 398579:SPEA_RS09830
uniprot id: A8H3Q9
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

398579:SPEA RS01430
gene id: 398579:SPEA_RS01430
uniprot id: A8GZ52
names: Similarity
messages: Belongs to the AOR/FOR family.

398579:SPEA RS15020
gene id: 398579:SPEA_RS15020
uniprot id: A8H6H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS16085
gene id: 398579:SPEA_RS16085
uniprot id: A8H733
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

398579:SPEA RS05065
gene id: 398579:SPEA_RS05065
uniprot id: A8H159
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

398579:SPEA RS07730
gene id: 398579:SPEA_RS07730
uniprot id: A8H2J5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS04380
gene id: 398579:SPEA_RS04380
uniprot id: A8H0S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

398579:SPEA RS21295
gene id: 398579:SPEA_RS21295
uniprot id: A8H9Y2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

398579:SPEA RS00355
gene id: 398579:SPEA_RS00355
uniprot id: A8GYK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

398579:SPEA RS19915
gene id: 398579:SPEA_RS19915
uniprot id: A8H967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

398579:SPEA RS19635
gene id: 398579:SPEA_RS19635
uniprot id: A8H911
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS11705
gene id: 398579:SPEA_RS11705
uniprot id: A8H4R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

398579:SPEA RS01985
gene id: 398579:SPEA_RS01985
uniprot id: A8GZF8
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS00370
gene id: 398579:SPEA_RS00370
uniprot id: A8GYK7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

398579:SPEA RS12465
gene id: 398579:SPEA_RS12465
uniprot id: A8H537
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

398579:SPEA RS00970
gene id: 398579:SPEA_RS00970
uniprot id: A8GYW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

398579:SPEA RS13730
gene id: 398579:SPEA_RS13730
uniprot id: A8H5S1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

398579:SPEA RS04505
gene id: 398579:SPEA_RS04505
uniprot id: A8H0V0
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

398579:SPEA RS08945
gene id: 398579:SPEA_RS08945
uniprot id: A8H390
names: Similarity
messages: Belongs to the proline racemase family.

398579:SPEA RS21235
gene id: 398579:SPEA_RS21235
uniprot id: A8H9X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

398579:SPEA RS15760
gene id: 398579:SPEA_RS15760
uniprot id: A8H6W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

398579:SPEA RS20695
gene id: 398579:SPEA_RS20695
uniprot id: A8H9L5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

398579:SPEA RS18610
gene id: 398579:SPEA_RS18610
uniprot id: A8H8G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

398579:SPEA RS14730
gene id: 398579:SPEA_RS14730
uniprot id: A8H6B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

398579:SPEA RS05225
gene id: 398579:SPEA_RS05225
uniprot id: A8H190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS07335
gene id: 398579:SPEA_RS07335
uniprot id: A8H2E2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

398579:SPEA RS15090
gene id: 398579:SPEA_RS15090
uniprot id: A8H6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

398579:SPEA RS05915
gene id: 398579:SPEA_RS05915
uniprot id: A8H1M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

398579:SPEA RS05465
gene id: 398579:SPEA_RS05465
uniprot id: A8H1D8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

398579:SPEA RS17905
gene id: 398579:SPEA_RS17905
uniprot id: A8H826
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS03830
gene id: 398579:SPEA_RS03830
uniprot id: A8H0G5
names: Similarity
messages: Belongs to the BMP lipoprotein family.

398579:SPEA RS20135
gene id: 398579:SPEA_RS20135
uniprot id: A8H9A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

398579:SPEA RS02260
gene id: 398579:SPEA_RS02260
uniprot id: A8GZL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 3 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

398579:SPEA RS00665
gene id: 398579:SPEA_RS00665
uniprot id: A8GYR7
names: Similarity
messages: Belongs to the catalase family.

398579:SPEA RS01830
gene id: 398579:SPEA_RS01830
uniprot id: A8GZD1
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

398579:SPEA RS12945
gene id: 398579:SPEA_RS12945
uniprot id: A8H5C8
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

398579:SPEA RS17680
gene id: 398579:SPEA_RS17680
uniprot id: A8H7Y2
names: Similarity
messages: Belongs to the universal stress protein A family.

398579:SPEA RS04365
gene id: 398579:SPEA_RS04365
uniprot id: A8H0S1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-552 family.
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 5 heme c groups covalently per monomer.
messages: Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
messages: Periplasm

398579:SPEA RS19160
gene id: 398579:SPEA_RS19160
uniprot id: A8H8R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

398579:SPEA RS00560
gene id: 398579:SPEA_RS00560
uniprot id: A8GYP5
names: Function
names: Similarity
messages: Belongs to the peptidase C56 family.
messages: Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate.

398579:SPEA RS21845
gene id: 398579:SPEA_RS21845
uniprot id: A8HA88
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS11270
gene id: 398579:SPEA_RS11270
uniprot id: A8H4H9
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

398579:SPEA RS08780
gene id: 398579:SPEA_RS08780
uniprot id: A8H356
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

398579:SPEA RS14170
gene id: 398579:SPEA_RS14170
uniprot id: A8H609
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
messages: Monomer.

398579:SPEA RS03190
gene id: 398579:SPEA_RS03190
uniprot id: A8H041
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

398579:SPEA RS10160
gene id: 398579:SPEA_RS10160
uniprot id: A8H3X6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS16195
gene id: 398579:SPEA_RS16195
uniprot id: A8H753
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

398579:SPEA RS16900
gene id: 398579:SPEA_RS16900
uniprot id: A8H7H6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS17940
gene id: 398579:SPEA_RS17940
uniprot id: A8H833
names: Function
names: Similarity
messages: Belongs to the peptidase S9C family.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

398579:SPEA RS19990
gene id: 398579:SPEA_RS19990
uniprot id: A8H976
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

398579:SPEA RS05565
gene id: 398579:SPEA_RS05565
uniprot id: A8H1F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

398579:SPEA RS04560
gene id: 398579:SPEA_RS04560
uniprot id: A8H0W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

398579:SPEA RS15235
gene id: 398579:SPEA_RS15235
uniprot id: A8H6L6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

398579:SPEA RS13410
gene id: 398579:SPEA_RS13410
uniprot id: A8H5L9
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

398579:SPEA RS05890
gene id: 398579:SPEA_RS05890
uniprot id: A8H1L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

398579:SPEA RS15605
gene id: 398579:SPEA_RS15605
uniprot id: A8H6T8
names: Similarity
messages: Belongs to the UPF0178 family.

398579:SPEA RS04240
gene id: 398579:SPEA_RS04240
uniprot id: A8H0P7
names: Similarity
messages: Belongs to the RecJ family.

398579:SPEA RS02365
gene id: 398579:SPEA_RS02365
uniprot id: A8GZN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhE family.
messages: Cytoplasm
messages: Necessary for formate dehydrogenase activity.

398579:SPEA RS20645
gene id: 398579:SPEA_RS20645
uniprot id: A8H9K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

398579:SPEA RS13350
gene id: 398579:SPEA_RS13350
uniprot id: A8H5K7
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

398579:SPEA RS10250
gene id: 398579:SPEA_RS10250
uniprot id: A8H3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

398579:SPEA RS05070
gene id: 398579:SPEA_RS05070
uniprot id: A8H160
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
messages: Belongs to the Lpp family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cell wall

398579:SPEA RS11350
gene id: 398579:SPEA_RS11350
uniprot id: A8H4J5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

398579:SPEA RS15995
gene id: 398579:SPEA_RS15995
uniprot id: A8H715
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS18895
gene id: 398579:SPEA_RS18895
uniprot id: A8H8L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

398579:SPEA RS16645
gene id: 398579:SPEA_RS16645
uniprot id: A8H7D1
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

398579:SPEA RS17555
gene id: 398579:SPEA_RS17555
uniprot id: A8H7V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

398579:SPEA RS11250
gene id: 398579:SPEA_RS11250
uniprot id: A8H4H5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS00325
gene id: 398579:SPEA_RS00325
uniprot id: A8GYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

398579:SPEA RS05230
gene id: 398579:SPEA_RS05230
uniprot id: A8H191
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

398579:SPEA RS13670
gene id: 398579:SPEA_RS13670
uniprot id: A8H5Q9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

398579:SPEA RS16155
gene id: 398579:SPEA_RS16155
uniprot id: A8H745
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

398579:SPEA RS21615
gene id: 398579:SPEA_RS21615
uniprot id: A8HA43
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

398579:SPEA RS16650
gene id: 398579:SPEA_RS16650
uniprot id: A8H7D2
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

398579:SPEA RS15615
gene id: 398579:SPEA_RS15615
uniprot id: A8H6U0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS18795
gene id: 398579:SPEA_RS18795
uniprot id: A8H8J6
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.

398579:SPEA RS12660
gene id: 398579:SPEA_RS12660
uniprot id: A8H576
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS16450
gene id: 398579:SPEA_RS16450
uniprot id: A8H7A5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

398579:SPEA RS10050
gene id: 398579:SPEA_RS10050
uniprot id: A8H3V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

398579:SPEA RS17110
gene id: 398579:SPEA_RS17110
uniprot id: A8H7L8
names: Similarity
messages: Belongs to the peptidase M13 family.

398579:SPEA RS09045
gene id: 398579:SPEA_RS09045
uniprot id: A8H3A6
names: Similarity
messages: Belongs to the UPF0319 family.

398579:SPEA RS03285
gene id: 398579:SPEA_RS03285
uniprot id: A8H061
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.
messages: Periplasm

398579:SPEA RS01260
gene id: 398579:SPEA_RS01260
uniprot id: A8GZ18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

398579:SPEA RS00165
gene id: 398579:SPEA_RS00165
uniprot id: A8GYH2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

398579:SPEA RS13475
gene id: 398579:SPEA_RS13475
uniprot id: A8H5N2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

398579:SPEA RS16560
gene id: 398579:SPEA_RS16560
uniprot id: A8H7B4
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

398579:SPEA RS06890
gene id: 398579:SPEA_RS06890
uniprot id: A8H256
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: In the C-terminal section; belongs to the transglycosylase Slt family.
messages: In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
messages: Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
messages: The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.

398579:SPEA RS12410
gene id: 398579:SPEA_RS12410
uniprot id: A8H534
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

398579:SPEA RS04350
gene id: 398579:SPEA_RS04350
uniprot id: A8H0R8
names: Similarity
messages: Belongs to the UPF0231 family.

398579:SPEA RS03525
gene id: 398579:SPEA_RS03525
uniprot id: A8H0A6
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

398579:SPEA RS04360
gene id: 398579:SPEA_RS04360
uniprot id: A8H0S0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS12855
gene id: 398579:SPEA_RS12855
uniprot id: A8H5B0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

398579:SPEA RS21620
gene id: 398579:SPEA_RS21620
uniprot id: A8HA44
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

398579:SPEA RS12815
gene id: 398579:SPEA_RS12815
uniprot id: A8H5A2
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

398579:SPEA RS13710
gene id: 398579:SPEA_RS13710
uniprot id: A8H5R7
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

398579:SPEA RS15240
gene id: 398579:SPEA_RS15240
uniprot id: A8H6L7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

398579:SPEA RS14715
gene id: 398579:SPEA_RS14715
uniprot id: A8H6B4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS01545
gene id: 398579:SPEA_RS01545
uniprot id: A8GZ75
names: Similarity
messages: Belongs to the peptidase S9C family.

398579:SPEA RS16550
gene id: 398579:SPEA_RS16550
uniprot id: A8H7B2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

398579:SPEA RS20170
gene id: 398579:SPEA_RS20170
uniprot id: A8H9B2
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

398579:SPEA RS09180
gene id: 398579:SPEA_RS09180
uniprot id: A8H3D3
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

398579:SPEA RS01060
gene id: 398579:SPEA_RS01060
uniprot id: A8GYY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

398579:SPEA RS04675
gene id: 398579:SPEA_RS04675
uniprot id: A8H0Y2
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS17060
gene id: 398579:SPEA_RS17060
uniprot id: A8H7K8
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

398579:SPEA RS09085
gene id: 398579:SPEA_RS09085
uniprot id: A8H3B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS01510
gene id: 398579:SPEA_RS01510
uniprot id: A8GZ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

398579:SPEA RS18505
gene id: 398579:SPEA_RS18505
uniprot id: A8H8E4
names: Similarity
messages: Belongs to the peptidase S9C family.

398579:SPEA RS00205
gene id: 398579:SPEA_RS00205
uniprot id: A8GYI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

398579:SPEA RS15165
gene id: 398579:SPEA_RS15165
uniprot id: A8H6K2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

398579:SPEA RS08785
gene id: 398579:SPEA_RS08785
uniprot id: A8H357
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0208 family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS02100
gene id: 398579:SPEA_RS02100
uniprot id: A8GZI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

398579:SPEA RS00200
gene id: 398579:SPEA_RS00200
uniprot id: A8GYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

398579:SPEA RS10545
gene id: 398579:SPEA_RS10545
uniprot id: A8H443
names: Similarity
messages: Belongs to the peptidase A24 family.

398579:SPEA RS08525
gene id: 398579:SPEA_RS08525
uniprot id: A8H308
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS19830
gene id: 398579:SPEA_RS19830
uniprot id: A8H950
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

398579:SPEA RS09105
gene id: 398579:SPEA_RS09105
uniprot id: A8H3B8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

398579:SPEA RS18025
gene id: 398579:SPEA_RS18025
uniprot id: A8H850
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS04670
gene id: 398579:SPEA_RS04670
uniprot id: A8H0Y1
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS13015
gene id: 398579:SPEA_RS13015
uniprot id: A8H5E1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

398579:SPEA RS16605
gene id: 398579:SPEA_RS16605
uniprot id: A8H7C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

398579:SPEA RS03050
gene id: 398579:SPEA_RS03050
uniprot id: A8H012
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

398579:SPEA RS14440
gene id: 398579:SPEA_RS14440
uniprot id: A8H660
names: Similarity
messages: Belongs to the phosphohexose mutase family.

398579:SPEA RS16270
gene id: 398579:SPEA_RS16270
uniprot id: A8H769
names: Similarity
messages: Belongs to the peptidase M17 family.

398579:SPEA RS11235
gene id: 398579:SPEA_RS11235
uniprot id: A8H4H2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS15525
gene id: 398579:SPEA_RS15525
uniprot id: A8H6S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

398579:SPEA RS20245
gene id: 398579:SPEA_RS20245
uniprot id: A8H9C7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS00770
gene id: 398579:SPEA_RS00770
uniprot id: A8GYT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

398579:SPEA RS15315
gene id: 398579:SPEA_RS15315
uniprot id: A8H6N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Syd family.
messages: Cell inner membrane
messages: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.

398579:SPEA RS20830
gene id: 398579:SPEA_RS20830
uniprot id: A8H9P2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS19705
gene id: 398579:SPEA_RS19705
uniprot id: A8H925
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

398579:SPEA RS08870
gene id: 398579:SPEA_RS08870
uniprot id: A8H375
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
messages: Interacts with FtsZ via their C-terminal domains.

398579:SPEA RS16975
gene id: 398579:SPEA_RS16975
uniprot id: A8H7J1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS11830
gene id: 398579:SPEA_RS11830
uniprot id: A8H4T7
names: Similarity
messages: Belongs to the asparaginase 1 family.

398579:SPEA RS16205
gene id: 398579:SPEA_RS16205
uniprot id: A8H755
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

398579:SPEA RS14200
gene id: 398579:SPEA_RS14200
uniprot id: A8H615
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

398579:SPEA RS00980
gene id: 398579:SPEA_RS00980
uniprot id: A8GYX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

398579:SPEA RS05600
gene id: 398579:SPEA_RS05600
uniprot id: A8H1G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

398579:SPEA RS17630
gene id: 398579:SPEA_RS17630
uniprot id: A8H7X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TorD/DmsD family. TorD subfamily.
messages: Cytoplasm
messages: Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.

398579:SPEA RS18355
gene id: 398579:SPEA_RS18355
uniprot id: A8H8B3
names: Similarity
messages: Belongs to the UPF0111 family.

398579:SPEA RS18865
gene id: 398579:SPEA_RS18865
uniprot id: A8H8K9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

398579:SPEA RS08105
gene id: 398579:SPEA_RS08105
uniprot id: A8H2S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinylarginine dihydrolase family.
messages: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
messages: Homodimer.

398579:SPEA RS03595
gene id: 398579:SPEA_RS03595
uniprot id: A8H0C0
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS21450
gene id: 398579:SPEA_RS21450
uniprot id: A8HA12
names: Function
names: Similarity
messages: Belongs to the isochorismate synthase family.
messages: Catalyzes the conversion of chorismate to isochorismate.

398579:SPEA RS03660
gene id: 398579:SPEA_RS03660
uniprot id: A8H0D3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

398579:SPEA RS14245
gene id: 398579:SPEA_RS14245
uniprot id: A8H621
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS14775
gene id: 398579:SPEA_RS14775
uniprot id: A8H6C6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS05490
gene id: 398579:SPEA_RS05490
uniprot id: A8H1E3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

398579:SPEA RS03760
gene id: 398579:SPEA_RS03760
uniprot id: A8H0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS15925
gene id: 398579:SPEA_RS15925
uniprot id: A8H701
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

398579:SPEA RS11695
gene id: 398579:SPEA_RS11695
uniprot id: A8H4R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

398579:SPEA RS09540
gene id: 398579:SPEA_RS09540
uniprot id: A8H3K5
names: Function
messages: May be involved in the biogenesis of curli organelles.

398579:SPEA RS00555
gene id: 398579:SPEA_RS00555
uniprot id: A8GYP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

398579:SPEA RS16925
gene id: 398579:SPEA_RS16925
uniprot id: A8H7I1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

398579:SPEA RS11390
gene id: 398579:SPEA_RS11390
uniprot id: A8H4K3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

398579:SPEA RS19545
gene id: 398579:SPEA_RS19545
uniprot id: A8H8Z3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

398579:SPEA RS18745
gene id: 398579:SPEA_RS18745
uniprot id: A8H8I6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.

398579:SPEA RS07175
gene id: 398579:SPEA_RS07175
uniprot id: A8H2B0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

398579:SPEA RS20155
gene id: 398579:SPEA_RS20155
uniprot id: A8H9A9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

398579:SPEA RS16335
gene id: 398579:SPEA_RS16335
uniprot id: A8H782
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS08625
gene id: 398579:SPEA_RS08625
uniprot id: A8H328
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

398579:SPEA RS10595
gene id: 398579:SPEA_RS10595
uniprot id: A8H453
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS10995
gene id: 398579:SPEA_RS10995
uniprot id: A8H4D3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

398579:SPEA RS04040
gene id: 398579:SPEA_RS04040
uniprot id: A8H0K7
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

398579:SPEA RS11260
gene id: 398579:SPEA_RS11260
uniprot id: A8H4H7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS11095
gene id: 398579:SPEA_RS11095
uniprot id: A8H4E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS14220
gene id: 398579:SPEA_RS14220
uniprot id: A8H616
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

398579:SPEA RS07905
gene id: 398579:SPEA_RS07905
uniprot id: A8H2N0
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.

398579:SPEA RS20725
gene id: 398579:SPEA_RS20725
uniprot id: A8H9M1
names: Similarity
messages: Belongs to the peptidase M16 family.

398579:SPEA RS19280
gene id: 398579:SPEA_RS19280
uniprot id: A8H8U0
names: Subcellular Location Annotation
messages: Cell outer membrane

398579:SPEA RS07540
gene id: 398579:SPEA_RS07540
uniprot id: A8H2I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapF family.
messages: Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

398579:SPEA RS12495
gene id: 398579:SPEA_RS12495
uniprot id: A8H543
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

398579:SPEA RS04155
gene id: 398579:SPEA_RS04155
uniprot id: A8H0N0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS01530
gene id: 398579:SPEA_RS01530
uniprot id: A8GZ72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family.
messages: Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).
messages: Cell inner membrane

398579:SPEA RS18945
gene id: 398579:SPEA_RS18945
uniprot id: A8H8M5
names: Similarity
messages: Belongs to the peptidase S1C family.

398579:SPEA RS07075
gene id: 398579:SPEA_RS07075
uniprot id: A8H291
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

398579:SPEA RS11685
gene id: 398579:SPEA_RS11685
uniprot id: A8H4R1
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

398579:SPEA RS21780
gene id: 398579:SPEA_RS21780
uniprot id: A8HA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS17090
gene id: 398579:SPEA_RS17090
uniprot id: A8H7L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Fimbrium

398579:SPEA RS00755
gene id: 398579:SPEA_RS00755
uniprot id: A8GYT5
names: Similarity
messages: Belongs to the GSP C family.

398579:SPEA RS13085
gene id: 398579:SPEA_RS13085
uniprot id: A8H5F5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS04990
gene id: 398579:SPEA_RS04990
uniprot id: A8H145
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

398579:SPEA RS19025
gene id: 398579:SPEA_RS19025
uniprot id: A8H8P1
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

398579:SPEA RS16150
gene id: 398579:SPEA_RS16150
uniprot id: A8H744
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

398579:SPEA RS10730
gene id: 398579:SPEA_RS10730
uniprot id: A8H480
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5DNU family.
messages: Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS18305
gene id: 398579:SPEA_RS18305
uniprot id: A8H8A3
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

398579:SPEA RS05325
gene id: 398579:SPEA_RS05325
uniprot id: A8H1B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MutH family.
messages: Cytoplasm
messages: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.

398579:SPEA RS17220
gene id: 398579:SPEA_RS17220
uniprot id: A8H7P0
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS09705
gene id: 398579:SPEA_RS09705
uniprot id: A8H3N7
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

398579:SPEA RS05805
gene id: 398579:SPEA_RS05805
uniprot id: A8H1J9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

398579:SPEA RS10225
gene id: 398579:SPEA_RS10225
uniprot id: A8H3Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

398579:SPEA RS08100
gene id: 398579:SPEA_RS08100
uniprot id: A8H2S1
names: Similarity
messages: Belongs to the intimin/invasin family.

398579:SPEA RS13390
gene id: 398579:SPEA_RS13390
uniprot id: A8H5L5
names: Similarity
messages: Belongs to the ClpA/ClpB family.

398579:SPEA RS07500
gene id: 398579:SPEA_RS07500
uniprot id: A8H2H5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

398579:SPEA RS15560
gene id: 398579:SPEA_RS15560
uniprot id: A8H6S9
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS07865
gene id: 398579:SPEA_RS07865
uniprot id: A8H2M2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

398579:SPEA RS03025
gene id: 398579:SPEA_RS03025
uniprot id: A8H007
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

398579:SPEA RS06080
gene id: 398579:SPEA_RS06080
uniprot id: A8H1Q4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

398579:SPEA RS15185
gene id: 398579:SPEA_RS15185
uniprot id: A8H6K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

398579:SPEA RS08285
gene id: 398579:SPEA_RS08285
uniprot id: A8H2V8
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS20720
gene id: 398579:SPEA_RS20720
uniprot id: A8H9M0
names: Similarity
messages: Belongs to the peptidase M16 family.

398579:SPEA RS20015
gene id: 398579:SPEA_RS20015
uniprot id: A8H981
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

398579:SPEA RS03340
gene id: 398579:SPEA_RS03340
uniprot id: A8H072
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

398579:SPEA RS18365
gene id: 398579:SPEA_RS18365
uniprot id: A8H8B5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS03105
gene id: 398579:SPEA_RS03105
uniprot id: A8H024
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

398579:SPEA RS03940
gene id: 398579:SPEA_RS03940
uniprot id: A8H0I7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.

398579:SPEA RS14070
gene id: 398579:SPEA_RS14070
uniprot id: A8H5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS12355
gene id: 398579:SPEA_RS12355
uniprot id: A8H528
names: Similarity
messages: Belongs to the UPF0381 family.

398579:SPEA RS07390
gene id: 398579:SPEA_RS07390
uniprot id: A8H2F3
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

398579:SPEA RS12780
gene id: 398579:SPEA_RS12780
uniprot id: A8H595
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell inner membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

398579:SPEA RS21510
gene id: 398579:SPEA_RS21510
uniprot id: A8HA24
names: Similarity
messages: Belongs to the intimin/invasin family.

398579:SPEA RS06555
gene id: 398579:SPEA_RS06555
uniprot id: A8H1Y8
names: Similarity
messages: Belongs to the YjdM family.

398579:SPEA RS07215
gene id: 398579:SPEA_RS07215
uniprot id: A8H2B8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

398579:SPEA RS06085
gene id: 398579:SPEA_RS06085
uniprot id: A8H1Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

398579:SPEA RS05505
gene id: 398579:SPEA_RS05505
uniprot id: A8H1E6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS00075
gene id: 398579:SPEA_RS00075
uniprot id: A8GYF5
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

398579:SPEA RS07835
gene id: 398579:SPEA_RS07835
uniprot id: A8H2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

398579:SPEA RS15785
gene id: 398579:SPEA_RS15785
uniprot id: A8H6X3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS03000
gene id: 398579:SPEA_RS03000
uniprot id: A8H002
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

398579:SPEA RS11420
gene id: 398579:SPEA_RS11420
uniprot id: A8H4K9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS05795
gene id: 398579:SPEA_RS05795
uniprot id: A8H1J7
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

398579:SPEA RS19900
gene id: 398579:SPEA_RS19900
uniprot id: A8H964
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraA family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
messages: Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.

398579:SPEA RS19605
gene id: 398579:SPEA_RS19605
uniprot id: A8H905
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

398579:SPEA RS22020
gene id: 398579:SPEA_RS22020
uniprot id: A8HAC3
names: Similarity
messages: Belongs to the peptidase C40 family.

398579:SPEA RS21750
gene id: 398579:SPEA_RS21750
uniprot id: A8HA69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 1618 of 23S rRNA.

398579:SPEA RS15845
gene id: 398579:SPEA_RS15845
uniprot id: A8H6Y5
names: Similarity
messages: Belongs to the DEAD box helicase family.

398579:SPEA RS20100
gene id: 398579:SPEA_RS20100
uniprot id: A8H998
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

398579:SPEA RS19525
gene id: 398579:SPEA_RS19525
uniprot id: A8H8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS15170
gene id: 398579:SPEA_RS15170
uniprot id: A8H6K3
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

398579:SPEA RS00145
gene id: 398579:SPEA_RS00145
uniprot id: A8GYG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
messages: Cell inner membrane

398579:SPEA RS06350
gene id: 398579:SPEA_RS06350
uniprot id: A8H1U7
names: Similarity
messages: Belongs to the peptidase M16 family.

398579:SPEA RS02570
gene id: 398579:SPEA_RS02570
uniprot id: A8GZS2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

398579:SPEA RS20525
gene id: 398579:SPEA_RS20525
uniprot id: A8H9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

398579:SPEA RS17810
gene id: 398579:SPEA_RS17810
uniprot id: A8H806
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

398579:SPEA RS07190
gene id: 398579:SPEA_RS07190
uniprot id: A8H2B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

398579:SPEA RS02085
gene id: 398579:SPEA_RS02085
uniprot id: A8GZH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

398579:SPEA RS03175
gene id: 398579:SPEA_RS03175
uniprot id: A8H038
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RsmC family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.

398579:SPEA RS02220
gene id: 398579:SPEA_RS02220
uniprot id: A8GZK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS21540
gene id: 398579:SPEA_RS21540
uniprot id: A8HA28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS04810
gene id: 398579:SPEA_RS04810
uniprot id: A8H109
names: Similarity
messages: Belongs to the DEAD box helicase family.

398579:SPEA RS08610
gene id: 398579:SPEA_RS08610
uniprot id: A8H325
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

398579:SPEA RS04455
gene id: 398579:SPEA_RS04455
uniprot id: A8H0U0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Homodimer.

398579:SPEA RS12510
gene id: 398579:SPEA_RS12510
uniprot id: A8H546
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

398579:SPEA RS12045
gene id: 398579:SPEA_RS12045
uniprot id: A8H4W9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

398579:SPEA RS02115
gene id: 398579:SPEA_RS02115
uniprot id: A8GZI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS20345
gene id: 398579:SPEA_RS20345
uniprot id: A8H9E6
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

398579:SPEA RS01455
gene id: 398579:SPEA_RS01455
uniprot id: A8GZ57
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS18685
gene id: 398579:SPEA_RS18685
uniprot id: A8H8H4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

398579:SPEA RS12240
gene id: 398579:SPEA_RS12240
uniprot id: A8H505
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
messages: Homotetramer; dimer of dimers.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.

398579:SPEA RS05340
gene id: 398579:SPEA_RS05340
uniprot id: A8H1B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS13485
gene id: 398579:SPEA_RS13485
uniprot id: A8H5N4
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

398579:SPEA RS20880
gene id: 398579:SPEA_RS20880
uniprot id: A8H9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

398579:SPEA RS21035
gene id: 398579:SPEA_RS21035
uniprot id: A8H9T0
names: Similarity
messages: Belongs to the SCO1/2 family.

398579:SPEA RS04460
gene id: 398579:SPEA_RS04460
uniprot id: A8H0U1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

398579:SPEA RS17170
gene id: 398579:SPEA_RS17170
uniprot id: A8H7N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane

398579:SPEA RS00905
gene id: 398579:SPEA_RS00905
uniprot id: A8GYV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

398579:SPEA RS00150
gene id: 398579:SPEA_RS00150
uniprot id: A8GYG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

398579:SPEA RS16035
gene id: 398579:SPEA_RS16035
uniprot id: A8H723
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

398579:SPEA RS21755
gene id: 398579:SPEA_RS21755
uniprot id: A8HA70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

398579:SPEA RS20050
gene id: 398579:SPEA_RS20050
uniprot id: A8H988
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

398579:SPEA RS22335
gene id: 398579:SPEA_RS22335
uniprot id: A8HAH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

398579:SPEA RS19910
gene id: 398579:SPEA_RS19910
uniprot id: A8H966
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

398579:SPEA RS19005
gene id: 398579:SPEA_RS19005
uniprot id: A8H8N7
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

398579:SPEA RS13820
gene id: 398579:SPEA_RS13820
uniprot id: A8H5U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS08510
gene id: 398579:SPEA_RS08510
uniprot id: A8H305
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

398579:SPEA RS06905
gene id: 398579:SPEA_RS06905
uniprot id: A8H259
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

398579:SPEA RS07305
gene id: 398579:SPEA_RS07305
uniprot id: A8H2D6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS02765
gene id: 398579:SPEA_RS02765
uniprot id: A8GZW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

398579:SPEA RS04960
gene id: 398579:SPEA_RS04960
uniprot id: A8H139
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

398579:SPEA RS08320
gene id: 398579:SPEA_RS08320
uniprot id: A8H2W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS10635
gene id: 398579:SPEA_RS10635
uniprot id: A8H461
names: Function
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.

398579:SPEA RS08795
gene id: 398579:SPEA_RS08795
uniprot id: A8H359
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS22760
gene id: 398579:SPEA_RS22760
uniprot id: A8H3Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribosome modulation factor family.
messages: Cytoplasm
messages: During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).

398579:SPEA RS22300
gene id: 398579:SPEA_RS22300
uniprot id: A8HAH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

398579:SPEA RS01930
gene id: 398579:SPEA_RS01930
uniprot id: A8GZF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

398579:SPEA RS19400
gene id: 398579:SPEA_RS19400
uniprot id: A8H8W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

398579:SPEA RS04820
gene id: 398579:SPEA_RS04820
uniprot id: A8H111
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS07310
gene id: 398579:SPEA_RS07310
uniprot id: A8H2D7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

398579:SPEA RS08895
gene id: 398579:SPEA_RS08895
uniprot id: A8H380
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

398579:SPEA RS17895
gene id: 398579:SPEA_RS17895
uniprot id: A8H824
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

398579:SPEA RS03975
gene id: 398579:SPEA_RS03975
uniprot id: A8H0J4
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

398579:SPEA RS21585
gene id: 398579:SPEA_RS21585
uniprot id: A8HA37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

398579:SPEA RS13110
gene id: 398579:SPEA_RS13110
uniprot id: A8H5G1
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

398579:SPEA RS17325
gene id: 398579:SPEA_RS17325
uniprot id: A8H7R1
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS06370
gene id: 398579:SPEA_RS06370
uniprot id: A8H1V1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

398579:SPEA RS06330
gene id: 398579:SPEA_RS06330
uniprot id: A8H1U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

398579:SPEA RS10065
gene id: 398579:SPEA_RS10065
uniprot id: A8H3V7
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

398579:SPEA RS07225
gene id: 398579:SPEA_RS07225
uniprot id: A8H2C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).

398579:SPEA RS19775
gene id: 398579:SPEA_RS19775
uniprot id: A8H939
names: Similarity
messages: Belongs to the GSP E family.

398579:SPEA RS10215
gene id: 398579:SPEA_RS10215
uniprot id: A8H3Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

398579:SPEA RS15050
gene id: 398579:SPEA_RS15050
uniprot id: A8H6H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

398579:SPEA RS12915
gene id: 398579:SPEA_RS12915
uniprot id: A8H5C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

398579:SPEA RS16170
gene id: 398579:SPEA_RS16170
uniprot id: A8H748
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

398579:SPEA RS17270
gene id: 398579:SPEA_RS17270
uniprot id: A8H7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

398579:SPEA RS01725
gene id: 398579:SPEA_RS01725
uniprot id: A8GZB1
names: Subcellular Location Annotation
messages: Cell outer membrane

398579:SPEA RS16625
gene id: 398579:SPEA_RS16625
uniprot id: A8H7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

398579:SPEA RS08860
gene id: 398579:SPEA_RS08860
uniprot id: A8H373
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CysZ family.
messages: Cell inner membrane
messages: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.

398579:SPEA RS02320
gene id: 398579:SPEA_RS02320
uniprot id: A8GZM3
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

398579:SPEA RS15155
gene id: 398579:SPEA_RS15155
uniprot id: A8H6K0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

398579:SPEA RS01285
gene id: 398579:SPEA_RS01285
uniprot id: A8GZ23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

398579:SPEA RS09295
gene id: 398579:SPEA_RS09295
uniprot id: A8H3F5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS15945
gene id: 398579:SPEA_RS15945
uniprot id: A8H705
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

398579:SPEA RS19620
gene id: 398579:SPEA_RS19620
uniprot id: A8H908
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS16230
gene id: 398579:SPEA_RS16230
uniprot id: A8H760
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

398579:SPEA RS02290
gene id: 398579:SPEA_RS02290
uniprot id: A8GZL7
names: Similarity
messages: Belongs to the Rsd/AlgQ family.

398579:SPEA RS17450
gene id: 398579:SPEA_RS17450
uniprot id: A8H7T6
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

398579:SPEA RS16060
gene id: 398579:SPEA_RS16060
uniprot id: A8H728
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

398579:SPEA RS09980
gene id: 398579:SPEA_RS09980
uniprot id: A8H3U0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

398579:SPEA RS07970
gene id: 398579:SPEA_RS07970
uniprot id: A8H2P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS20045
gene id: 398579:SPEA_RS20045
uniprot id: A8H987
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

398579:SPEA RS01665
gene id: 398579:SPEA_RS01665
uniprot id: A8GZ99
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

398579:SPEA RS04400
gene id: 398579:SPEA_RS04400
uniprot id: A8H0S9
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS03450
gene id: 398579:SPEA_RS03450
uniprot id: A8H093
names: Cofactor
names: Function
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.

398579:SPEA RS21655
gene id: 398579:SPEA_RS21655
uniprot id: A8HA50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

398579:SPEA RS04290
gene id: 398579:SPEA_RS04290
uniprot id: A8H0Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

398579:SPEA RS14055
gene id: 398579:SPEA_RS14055
uniprot id: A8H5Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS16635
gene id: 398579:SPEA_RS16635
uniprot id: A8H7C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

398579:SPEA RS04750
gene id: 398579:SPEA_RS04750
uniprot id: A8H0Z7
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS12005
gene id: 398579:SPEA_RS12005
uniprot id: A8H4W2
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS02235
gene id: 398579:SPEA_RS02235
uniprot id: A8GZK6
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

398579:SPEA RS05105
gene id: 398579:SPEA_RS05105
uniprot id: A8H167
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS13170
gene id: 398579:SPEA_RS13170
uniprot id: A8H5H3
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

398579:SPEA RS18360
gene id: 398579:SPEA_RS18360
uniprot id: A8H8B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

398579:SPEA RS02500
gene id: 398579:SPEA_RS02500
uniprot id: A8GZQ8
names: Similarity
messages: Belongs to the RutC family.

398579:SPEA RS04420
gene id: 398579:SPEA_RS04420
uniprot id: A8H0T3
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

398579:SPEA RS01920
gene id: 398579:SPEA_RS01920
uniprot id: A8GZE9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS16570
gene id: 398579:SPEA_RS16570
uniprot id: A8H7B6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS19015
gene id: 398579:SPEA_RS19015
uniprot id: A8H8N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptC family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
messages: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

398579:SPEA RS20715
gene id: 398579:SPEA_RS20715
uniprot id: A8H9L9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

398579:SPEA RS12470
gene id: 398579:SPEA_RS12470
uniprot id: A8H538
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

398579:SPEA RS00125
gene id: 398579:SPEA_RS00125
uniprot id: A8GYG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
messages: Cell inner membrane

398579:SPEA RS03110
gene id: 398579:SPEA_RS03110
uniprot id: A8H025
names: Similarity
messages: Belongs to the CutA family.

398579:SPEA RS18320
gene id: 398579:SPEA_RS18320
uniprot id: A8H8A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS06230
gene id: 398579:SPEA_RS06230
uniprot id: A8H1T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

398579:SPEA RS00160
gene id: 398579:SPEA_RS00160
uniprot id: A8GYH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

398579:SPEA RS06965
gene id: 398579:SPEA_RS06965
uniprot id: A8H270
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS02685
gene id: 398579:SPEA_RS02685
uniprot id: A8GZU6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

398579:SPEA RS06355
gene id: 398579:SPEA_RS06355
uniprot id: A8H1U8
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

398579:SPEA RS02315
gene id: 398579:SPEA_RS02315
uniprot id: A8GZM2
names: Similarity
messages: Belongs to the GARS family.

398579:SPEA RS05260
gene id: 398579:SPEA_RS05260
uniprot id: A8H197
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

398579:SPEA RS13705
gene id: 398579:SPEA_RS13705
uniprot id: A8H5R6
names: Similarity
messages: Belongs to the asparagine synthetase family.

398579:SPEA RS10690
gene id: 398579:SPEA_RS10690
uniprot id: A8H472
names: Similarity
messages: Belongs to the peptidase S9C family.

398579:SPEA RS03045
gene id: 398579:SPEA_RS03045
uniprot id: A8H011
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS14375
gene id: 398579:SPEA_RS14375
uniprot id: A8H647
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

398579:SPEA RS05925
gene id: 398579:SPEA_RS05925
uniprot id: A8H1M3
names: Similarity
messages: Belongs to the SUI1 family.

398579:SPEA RS01745
gene id: 398579:SPEA_RS01745
uniprot id: A8GZB5
names: Subcellular Location Annotation
messages: Periplasm

398579:SPEA RS15225
gene id: 398579:SPEA_RS15225
uniprot id: A8H6L4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS09470
gene id: 398579:SPEA_RS09470
uniprot id: A8H3J1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane

398579:SPEA RS04220
gene id: 398579:SPEA_RS04220
uniprot id: A8H0P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

398579:SPEA RS19855
gene id: 398579:SPEA_RS19855
uniprot id: A8H955
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

398579:SPEA RS20190
gene id: 398579:SPEA_RS20190
uniprot id: A8H9B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

398579:SPEA RS00120
gene id: 398579:SPEA_RS00120
uniprot id: A8GYG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

398579:SPEA RS12730
gene id: 398579:SPEA_RS12730
uniprot id: A8H585
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

398579:SPEA RS05700
gene id: 398579:SPEA_RS05700
uniprot id: A8H1I4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS06250
gene id: 398579:SPEA_RS06250
uniprot id: A8H1T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

398579:SPEA RS17805
gene id: 398579:SPEA_RS17805
uniprot id: A8H805
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

398579:SPEA RS07900
gene id: 398579:SPEA_RS07900
uniprot id: A8H2M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity.

398579:SPEA RS07025
gene id: 398579:SPEA_RS07025
uniprot id: A8H281
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

398579:SPEA RS02665
gene id: 398579:SPEA_RS02665
uniprot id: A8GZU2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

398579:SPEA RS18040
gene id: 398579:SPEA_RS18040
uniprot id: A8H853
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS20935
gene id: 398579:SPEA_RS20935
uniprot id: A8H9R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

398579:SPEA RS18845
gene id: 398579:SPEA_RS18845
uniprot id: A8H8K6
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

398579:SPEA RS13810
gene id: 398579:SPEA_RS13810
uniprot id: A8H5T9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

398579:SPEA RS08315
gene id: 398579:SPEA_RS08315
uniprot id: A8H2W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS16435
gene id: 398579:SPEA_RS16435
uniprot id: A8H7A2
names: Similarity
messages: Belongs to the UPF0162 family.

398579:SPEA RS09300
gene id: 398579:SPEA_RS09300
uniprot id: A8H3F6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS19290
gene id: 398579:SPEA_RS19290
uniprot id: A8H8U2
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

398579:SPEA RS03305
gene id: 398579:SPEA_RS03305
uniprot id: A8H065
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

398579:SPEA RS08910
gene id: 398579:SPEA_RS08910
uniprot id: A8H383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

398579:SPEA RS06900
gene id: 398579:SPEA_RS06900
uniprot id: A8H258
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS01075
gene id: 398579:SPEA_RS01075
uniprot id: A8GYZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

398579:SPEA RS00765
gene id: 398579:SPEA_RS00765
uniprot id: A8GYT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
messages: Belongs to the GSP E family.
messages: Cell inner membrane

398579:SPEA RS11395
gene id: 398579:SPEA_RS11395
uniprot id: A8H4K4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

398579:SPEA RS06875
gene id: 398579:SPEA_RS06875
uniprot id: A8H253
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

398579:SPEA RS06305
gene id: 398579:SPEA_RS06305
uniprot id: A8H1T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

398579:SPEA RS20030
gene id: 398579:SPEA_RS20030
uniprot id: A8H984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

398579:SPEA RS18615
gene id: 398579:SPEA_RS18615
uniprot id: A8H8G6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

398579:SPEA RS14595
gene id: 398579:SPEA_RS14595
uniprot id: A8H690
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

398579:SPEA RS08090
gene id: 398579:SPEA_RS08090
uniprot id: A8H2R9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

398579:SPEA RS10310
gene id: 398579:SPEA_RS10310
uniprot id: A8H3Z9
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

398579:SPEA RS07150
gene id: 398579:SPEA_RS07150
uniprot id: A8H2A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS01630
gene id: 398579:SPEA_RS01630
uniprot id: A8GZ92
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

398579:SPEA RS12295
gene id: 398579:SPEA_RS12295
uniprot id: A8H516
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

398579:SPEA RS13265
gene id: 398579:SPEA_RS13265
uniprot id: A8H5J0
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

398579:SPEA RS17095
gene id: 398579:SPEA_RS17095
uniprot id: A8H7L5
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.

398579:SPEA RS05595
gene id: 398579:SPEA_RS05595
uniprot id: A8H1G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

398579:SPEA RS13605
gene id: 398579:SPEA_RS13605
uniprot id: A8H5P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

398579:SPEA RS00790
gene id: 398579:SPEA_RS00790
uniprot id: A8GYU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP J family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS05045
gene id: 398579:SPEA_RS05045
uniprot id: A8H155
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

398579:SPEA RS08745
gene id: 398579:SPEA_RS08745
uniprot id: A8H349
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS21325
gene id: 398579:SPEA_RS21325
uniprot id: A8H9Y8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

398579:SPEA RS02165
gene id: 398579:SPEA_RS02165
uniprot id: A8GZJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS16985
gene id: 398579:SPEA_RS16985
uniprot id: A8H7J3
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

398579:SPEA RS18045
gene id: 398579:SPEA_RS18045
uniprot id: A8H854
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS00095
gene id: 398579:SPEA_RS00095
uniprot id: A8GYF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

398579:SPEA RS11570
gene id: 398579:SPEA_RS11570
uniprot id: A8H4N9
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS11190
gene id: 398579:SPEA_RS11190
uniprot id: A8H4G3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS04235
gene id: 398579:SPEA_RS04235
uniprot id: A8H0P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

398579:SPEA RS09205
gene id: 398579:SPEA_RS09205
uniprot id: A8H3D8
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS16465
gene id: 398579:SPEA_RS16465
uniprot id: A8H7A8
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

398579:SPEA RS13180
gene id: 398579:SPEA_RS13180
uniprot id: A8H5H5
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

398579:SPEA RS12065
gene id: 398579:SPEA_RS12065
uniprot id: A8H4X3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
messages: Membrane

398579:SPEA RS00430
gene id: 398579:SPEA_RS00430
uniprot id: A8GYL9
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

398579:SPEA RS20610
gene id: 398579:SPEA_RS20610
uniprot id: A8H9J8
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

398579:SPEA RS21050
gene id: 398579:SPEA_RS21050
uniprot id: A8H9T3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

398579:SPEA RS13120
gene id: 398579:SPEA_RS13120
uniprot id: A8H5G3
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

398579:SPEA RS02995
gene id: 398579:SPEA_RS02995
uniprot id: A8H001
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

398579:SPEA RS16325
gene id: 398579:SPEA_RS16325
uniprot id: A8H780
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS03635
gene id: 398579:SPEA_RS03635
uniprot id: A8H0C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.

398579:SPEA RS20810
gene id: 398579:SPEA_RS20810
uniprot id: A8H9N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

398579:SPEA RS13675
gene id: 398579:SPEA_RS13675
uniprot id: A8H5R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

398579:SPEA RS14835
gene id: 398579:SPEA_RS14835
uniprot id: A8H6D6
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

398579:SPEA RS17720
gene id: 398579:SPEA_RS17720
uniprot id: A8H7Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

398579:SPEA RS00280
gene id: 398579:SPEA_RS00280
uniprot id: A8GYI9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

398579:SPEA RS21910
gene id: 398579:SPEA_RS21910
uniprot id: A8HAA1
names: Similarity
messages: Belongs to the transglycosylase Slt family.

398579:SPEA RS16225
gene id: 398579:SPEA_RS16225
uniprot id: A8H759
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

398579:SPEA RS02255
gene id: 398579:SPEA_RS02255
uniprot id: A8GZL0
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

398579:SPEA RS05750
gene id: 398579:SPEA_RS05750
uniprot id: A8H1J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

398579:SPEA RS05055
gene id: 398579:SPEA_RS05055
uniprot id: A8H157
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

398579:SPEA RS21095
gene id: 398579:SPEA_RS21095
uniprot id: A8H9U2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

398579:SPEA RS03440
gene id: 398579:SPEA_RS03440
uniprot id: A8H091
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

398579:SPEA RS08010
gene id: 398579:SPEA_RS08010
uniprot id: A8H2Q3
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

398579:SPEA RS06155
gene id: 398579:SPEA_RS06155
uniprot id: A8H1R8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS20250
gene id: 398579:SPEA_RS20250
uniprot id: A8H9C8
names: Similarity
messages: Belongs to the UxaA family.

398579:SPEA RS05050
gene id: 398579:SPEA_RS05050
uniprot id: A8H156
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

398579:SPEA RS12590
gene id: 398579:SPEA_RS12590
uniprot id: A8H562
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

398579:SPEA RS03080
gene id: 398579:SPEA_RS03080
uniprot id: A8H018
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

398579:SPEA RS01475
gene id: 398579:SPEA_RS01475
uniprot id: A8GZ61
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

398579:SPEA RS12300
gene id: 398579:SPEA_RS12300
uniprot id: A8H517
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

398579:SPEA RS02090
gene id: 398579:SPEA_RS02090
uniprot id: A8GZI0
names: Function
names: Similarity
names: Subunit
messages: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
messages: Belongs to the transcriptional regulatory Fis family.
messages: Homodimer.

398579:SPEA RS11875
gene id: 398579:SPEA_RS11875
uniprot id: A8H4U6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS14380
gene id: 398579:SPEA_RS14380
uniprot id: A8H648
names: Similarity
messages: Belongs to the group II decarboxylase family.

398579:SPEA RS10360
gene id: 398579:SPEA_RS10360
uniprot id: A8H409
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS19520
gene id: 398579:SPEA_RS19520
uniprot id: A8H8Y7
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

398579:SPEA RS05480
gene id: 398579:SPEA_RS05480
uniprot id: A8H1E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

398579:SPEA RS07740
gene id: 398579:SPEA_RS07740
uniprot id: A8H2J7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

398579:SPEA RS09385
gene id: 398579:SPEA_RS09385
uniprot id: A8H3H4
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

398579:SPEA RS19930
gene id: 398579:SPEA_RS19930
uniprot id: A8H970
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

398579:SPEA RS18405
gene id: 398579:SPEA_RS18405
uniprot id: A8H8C4
names: Similarity
messages: Belongs to the DEAD box helicase family.

398579:SPEA RS06510
gene id: 398579:SPEA_RS06510
uniprot id: A8H1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Membrane

398579:SPEA RS10720
gene id: 398579:SPEA_RS10720
uniprot id: A8H478
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS19955
gene id: 398579:SPEA_RS19955
uniprot id: A8H975
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

398579:SPEA RS18920
gene id: 398579:SPEA_RS18920
uniprot id: A8H8M0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

398579:SPEA RS02020
gene id: 398579:SPEA_RS02020
uniprot id: A8GZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-1 family.
messages: Cytoplasm

398579:SPEA RS20385
gene id: 398579:SPEA_RS20385
uniprot id: A8H9F3
names: Similarity
messages: Belongs to the RutC family.

398579:SPEA RS22250
gene id: 398579:SPEA_RS22250
uniprot id: A8HAG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

398579:SPEA RS09585
gene id: 398579:SPEA_RS09585
uniprot id: A8H3L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS12525
gene id: 398579:SPEA_RS12525
uniprot id: A8H549
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS05740
gene id: 398579:SPEA_RS05740
uniprot id: A8H1J2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

398579:SPEA RS02720
gene id: 398579:SPEA_RS02720
uniprot id: A8GZV3
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS16130
gene id: 398579:SPEA_RS16130
uniprot id: A8H742
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

398579:SPEA RS12040
gene id: 398579:SPEA_RS12040
uniprot id: A8H4W8
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

398579:SPEA RS00590
gene id: 398579:SPEA_RS00590
uniprot id: A8GYQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

398579:SPEA RS22280
gene id: 398579:SPEA_RS22280
uniprot id: A8HAG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

398579:SPEA RS10090
gene id: 398579:SPEA_RS10090
uniprot id: A8H3W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.

398579:SPEA RS01865
gene id: 398579:SPEA_RS01865
uniprot id: A8GZD8
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

398579:SPEA RS04890
gene id: 398579:SPEA_RS04890
uniprot id: A8H126
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

398579:SPEA RS09410
gene id: 398579:SPEA_RS09410
uniprot id: A8H3H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS05335
gene id: 398579:SPEA_RS05335
uniprot id: A8H1B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

398579:SPEA RS05190
gene id: 398579:SPEA_RS05190
uniprot id: A8H183
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

398579:SPEA RS20375
gene id: 398579:SPEA_RS20375
uniprot id: A8H9F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

398579:SPEA RS08665
gene id: 398579:SPEA_RS08665
uniprot id: A8H336
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

398579:SPEA RS21340
gene id: 398579:SPEA_RS21340
uniprot id: A8H9Z1
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

398579:SPEA RS11065
gene id: 398579:SPEA_RS11065
uniprot id: A8H4E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

398579:SPEA RS13195
gene id: 398579:SPEA_RS13195
uniprot id: A8H5H8
names: Similarity
messages: Belongs to the fabD family.

398579:SPEA RS02360
gene id: 398579:SPEA_RS02360
uniprot id: A8GZN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

398579:SPEA RS06190
gene id: 398579:SPEA_RS06190
uniprot id: A8H1S5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

398579:SPEA RS05560
gene id: 398579:SPEA_RS05560
uniprot id: A8H1F6
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

398579:SPEA RS12560
gene id: 398579:SPEA_RS12560
uniprot id: A8H556
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

398579:SPEA RS01015
gene id: 398579:SPEA_RS01015
uniprot id: A8GYX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

398579:SPEA RS11015
gene id: 398579:SPEA_RS11015
uniprot id: A8H4D7
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

398579:SPEA RS04685
gene id: 398579:SPEA_RS04685
uniprot id: A8H0Y4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS19185
gene id: 398579:SPEA_RS19185
uniprot id: A8H8S2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

398579:SPEA RS22055
gene id: 398579:SPEA_RS22055
uniprot id: A8HAD0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS14795
gene id: 398579:SPEA_RS14795
uniprot id: A8H6D0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS09875
gene id: 398579:SPEA_RS09875
uniprot id: A8H3R8
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

398579:SPEA RS05385
gene id: 398579:SPEA_RS05385
uniprot id: A8H1C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
messages: Belongs to the RseA family.
messages: Cell inner membrane
messages: Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E-regulated genes. Interacts with RseB.

398579:SPEA RS09030
gene id: 398579:SPEA_RS09030
uniprot id: A8H3A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

398579:SPEA RS10515
gene id: 398579:SPEA_RS10515
uniprot id: A8H439
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS01140
gene id: 398579:SPEA_RS01140
uniprot id: A8GZ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

398579:SPEA RS03520
gene id: 398579:SPEA_RS03520
uniprot id: A8H0A5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS13770
gene id: 398579:SPEA_RS13770
uniprot id: A8H5T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

398579:SPEA RS01095
gene id: 398579:SPEA_RS01095
uniprot id: A8GYZ4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

398579:SPEA RS12925
gene id: 398579:SPEA_RS12925
uniprot id: A8H5C4
names: Similarity
messages: Belongs to the UPF0260 family.

398579:SPEA RS10900
gene id: 398579:SPEA_RS10900
uniprot id: A8H4B4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS05215
gene id: 398579:SPEA_RS05215
uniprot id: A8H188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

398579:SPEA RS09395
gene id: 398579:SPEA_RS09395
uniprot id: A8H3H6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

398579:SPEA RS11490
gene id: 398579:SPEA_RS11490
uniprot id: A8H4M3
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS21405
gene id: 398579:SPEA_RS21405
uniprot id: A8HA04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

398579:SPEA RS09380
gene id: 398579:SPEA_RS09380
uniprot id: A8H3H3
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

398579:SPEA RS10425
gene id: 398579:SPEA_RS10425
uniprot id: A8H421
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

398579:SPEA RS17050
gene id: 398579:SPEA_RS17050
uniprot id: A8H7K6
names: Similarity
messages: Belongs to the glutamate synthase family.

398579:SPEA RS18785
gene id: 398579:SPEA_RS18785
uniprot id: A8H8J4
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS12485
gene id: 398579:SPEA_RS12485
uniprot id: A8H541
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

398579:SPEA RS05570
gene id: 398579:SPEA_RS05570
uniprot id: A8H1F8
names: Similarity
messages: Belongs to the threonine synthase family.

398579:SPEA RS21865
gene id: 398579:SPEA_RS21865
uniprot id: A8HA92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

398579:SPEA RS11780
gene id: 398579:SPEA_RS11780
uniprot id: A8H4S9
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

398579:SPEA RS07060
gene id: 398579:SPEA_RS07060
uniprot id: A8H288
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

398579:SPEA RS11335
gene id: 398579:SPEA_RS11335
uniprot id: A8H4J2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS00545
gene id: 398579:SPEA_RS00545
uniprot id: A8GYP2
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

398579:SPEA RS04475
gene id: 398579:SPEA_RS04475
uniprot id: A8H0U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS21170
gene id: 398579:SPEA_RS21170
uniprot id: A8H9V7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

398579:SPEA RS15200
gene id: 398579:SPEA_RS15200
uniprot id: A8H6K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

398579:SPEA RS20040
gene id: 398579:SPEA_RS20040
uniprot id: A8H986
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

398579:SPEA RS04490
gene id: 398579:SPEA_RS04490
uniprot id: A8H0U7
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

398579:SPEA RS00910
gene id: 398579:SPEA_RS00910
uniprot id: A8GYW0
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.

398579:SPEA RS06895
gene id: 398579:SPEA_RS06895
uniprot id: A8H257
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

398579:SPEA RS13365
gene id: 398579:SPEA_RS13365
uniprot id: A8H5L0
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

398579:SPEA RS02060
gene id: 398579:SPEA_RS02060
uniprot id: A8GZH4
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS16575
gene id: 398579:SPEA_RS16575
uniprot id: A8H7B7
names: Similarity
messages: Belongs to the PhoH family.

398579:SPEA RS05825
gene id: 398579:SPEA_RS05825
uniprot id: A8H1K3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS11760
gene id: 398579:SPEA_RS11760
uniprot id: A8H4S5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

398579:SPEA RS15330
gene id: 398579:SPEA_RS15330
uniprot id: A8H6N5
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

398579:SPEA RS15250
gene id: 398579:SPEA_RS15250
uniprot id: A8H6L9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

398579:SPEA RS14260
gene id: 398579:SPEA_RS14260
uniprot id: A8H624
names: Similarity
messages: Belongs to the FeoA family.

398579:SPEA RS02205
gene id: 398579:SPEA_RS02205
uniprot id: A8GZK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

398579:SPEA RS14330
gene id: 398579:SPEA_RS14330
uniprot id: A8H638
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS09840
gene id: 398579:SPEA_RS09840
uniprot id: A8H3R1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS21355
gene id: 398579:SPEA_RS21355
uniprot id: A8H9Z4
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS06105
gene id: 398579:SPEA_RS06105
uniprot id: A8H1Q9
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

398579:SPEA RS17425
gene id: 398579:SPEA_RS17425
uniprot id: A8H7T0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

398579:SPEA RS01760
gene id: 398579:SPEA_RS01760
uniprot id: A8GZB8
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

398579:SPEA RS16805
gene id: 398579:SPEA_RS16805
uniprot id: A8H7F6
names: Similarity
messages: Belongs to the peptidase M13 family.

398579:SPEA RS09305
gene id: 398579:SPEA_RS09305
uniprot id: A8H3F7
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

398579:SPEA RS10345
gene id: 398579:SPEA_RS10345
uniprot id: A8H406
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48 family. BepA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
messages: Periplasm

398579:SPEA RS05025
gene id: 398579:SPEA_RS05025
uniprot id: A8H151
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

398579:SPEA RS01690
gene id: 398579:SPEA_RS01690
uniprot id: A8GZA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapB family.
messages: Cytoplasm
messages: Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.
messages: Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.

398579:SPEA RS00960
gene id: 398579:SPEA_RS00960
uniprot id: A8GYW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

398579:SPEA RS07290
gene id: 398579:SPEA_RS07290
uniprot id: A8H2D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RfaH family.
messages: Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.
messages: Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

398579:SPEA RS13385
gene id: 398579:SPEA_RS13385
uniprot id: A8H5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

398579:SPEA RS01020
gene id: 398579:SPEA_RS01020
uniprot id: A8GYX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

398579:SPEA RS14450
gene id: 398579:SPEA_RS14450
uniprot id: A8H662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

398579:SPEA RS03435
gene id: 398579:SPEA_RS03435
uniprot id: A8H090
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

398579:SPEA RS16125
gene id: 398579:SPEA_RS16125
uniprot id: A8H741
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

398579:SPEA RS00390
gene id: 398579:SPEA_RS00390
uniprot id: A8GYL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

398579:SPEA RS02470
gene id: 398579:SPEA_RS02470
uniprot id: A8GZQ3
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS10455
gene id: 398579:SPEA_RS10455
uniprot id: A8H427
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

398579:SPEA RS10660
gene id: 398579:SPEA_RS10660
uniprot id: A8H466
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

398579:SPEA RS01130
gene id: 398579:SPEA_RS01130
uniprot id: A8GZ01
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

398579:SPEA RS00795
gene id: 398579:SPEA_RS00795
uniprot id: A8GYU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS03180
gene id: 398579:SPEA_RS03180
uniprot id: A8H039
names: Similarity
messages: Belongs to the alkaline phosphatase family.

398579:SPEA RS03515
gene id: 398579:SPEA_RS03515
uniprot id: A8H0A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

398579:SPEA RS00040
gene id: 398579:SPEA_RS00040
uniprot id: A8GYE8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

398579:SPEA RS22195
gene id: 398579:SPEA_RS22195
uniprot id: A8HAF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

398579:SPEA RS20290
gene id: 398579:SPEA_RS20290
uniprot id: A8H9D5
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

398579:SPEA RS03455
gene id: 398579:SPEA_RS03455
uniprot id: A8H094
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

398579:SPEA RS14195
gene id: 398579:SPEA_RS14195
uniprot id: A8H614
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

398579:SPEA RS00575
gene id: 398579:SPEA_RS00575
uniprot id: A8GYP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

398579:SPEA RS02395
gene id: 398579:SPEA_RS02395
uniprot id: A8GZN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

398579:SPEA RS19205
gene id: 398579:SPEA_RS19205
uniprot id: A8H8S6
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

398579:SPEA RS15880
gene id: 398579:SPEA_RS15880
uniprot id: A8H6Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OprB family.
messages: Cell outer membrane

398579:SPEA RS16885
gene id: 398579:SPEA_RS16885
uniprot id: A8H7H3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

398579:SPEA RS18930
gene id: 398579:SPEA_RS18930
uniprot id: A8H8M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AFG1 ATPase family. ZapE subfamily.
messages: Cytoplasm
messages: Interacts with FtsZ.
messages: Reduces the stability of FtsZ polymers in the presence of ATP.

398579:SPEA RS17800
gene id: 398579:SPEA_RS17800
uniprot id: A8H804
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

398579:SPEA RS05165
gene id: 398579:SPEA_RS05165
uniprot id: A8H178
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell inner membrane
messages: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS08350
gene id: 398579:SPEA_RS08350
uniprot id: A8H2X4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

398579:SPEA RS11725
gene id: 398579:SPEA_RS11725
uniprot id: A8H4R9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS05170
gene id: 398579:SPEA_RS05170
uniprot id: A8H179
names: Similarity
messages: Belongs to the alkaline phosphatase family.

398579:SPEA RS12790
gene id: 398579:SPEA_RS12790
uniprot id: A8H597
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

398579:SPEA RS07035
gene id: 398579:SPEA_RS07035
uniprot id: A8H283
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

398579:SPEA RS05540
gene id: 398579:SPEA_RS05540
uniprot id: A8H1F2
names: PTM
messages: Binds 1 heme group per subunit.

398579:SPEA RS05200
gene id: 398579:SPEA_RS05200
uniprot id: A8H185
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS10340
gene id: 398579:SPEA_RS10340
uniprot id: A8H405
names: Similarity
messages: Belongs to the ArsC family.

398579:SPEA RS17875
gene id: 398579:SPEA_RS17875
uniprot id: A8H820
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS14725
gene id: 398579:SPEA_RS14725
uniprot id: A8H6B6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

398579:SPEA RS11820
gene id: 398579:SPEA_RS11820
uniprot id: A8H4T5
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

398579:SPEA RS06240
gene id: 398579:SPEA_RS06240
uniprot id: A8H1T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

398579:SPEA RS07165
gene id: 398579:SPEA_RS07165
uniprot id: A8H2A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

398579:SPEA RS09660
gene id: 398579:SPEA_RS09660
uniprot id: A8H3M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

398579:SPEA RS16655
gene id: 398579:SPEA_RS16655
uniprot id: A8H7D3
names: Similarity
messages: Belongs to the UPF0250 family.

398579:SPEA RS05290
gene id: 398579:SPEA_RS05290
uniprot id: A8H1A3
names: Similarity
messages: Belongs to the glutamate synthase family.

398579:SPEA RS14765
gene id: 398579:SPEA_RS14765
uniprot id: A8H6C4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

398579:SPEA RS08160
gene id: 398579:SPEA_RS08160
uniprot id: A8H2T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

398579:SPEA RS08415
gene id: 398579:SPEA_RS08415
uniprot id: A8H2Y7
names: Similarity
messages: Belongs to the peptidase S51 family.

398579:SPEA RS06090
gene id: 398579:SPEA_RS06090
uniprot id: A8H1Q6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

398579:SPEA RS09595
gene id: 398579:SPEA_RS09595
uniprot id: A8H3L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane
messages: Required for nicotinamide riboside transport across the inner membrane.

398579:SPEA RS16800
gene id: 398579:SPEA_RS16800
uniprot id: A8H7F5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

398579:SPEA RS20165
gene id: 398579:SPEA_RS20165
uniprot id: A8H9B1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

398579:SPEA RS00490
gene id: 398579:SPEA_RS00490
uniprot id: A8GYN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

398579:SPEA RS03410
gene id: 398579:SPEA_RS03410
uniprot id: A8H085
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family.
messages: Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).
messages: Cell inner membrane

398579:SPEA RS07205
gene id: 398579:SPEA_RS07205
uniprot id: A8H2B6
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

398579:SPEA RS15460
gene id: 398579:SPEA_RS15460
uniprot id: A8H6R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS08990
gene id: 398579:SPEA_RS08990
uniprot id: A8H399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

398579:SPEA RS18940
gene id: 398579:SPEA_RS18940
uniprot id: A8H8M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

398579:SPEA RS19030
gene id: 398579:SPEA_RS19030
uniprot id: A8H8P2
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

398579:SPEA RS12740
gene id: 398579:SPEA_RS12740
uniprot id: A8H587
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS04150
gene id: 398579:SPEA_RS04150
uniprot id: A8H0M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
messages: Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
messages: Cytoplasm
messages: Homotetramer.

398579:SPEA RS04430
gene id: 398579:SPEA_RS04430
uniprot id: A8H0T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

398579:SPEA RS16310
gene id: 398579:SPEA_RS16310
uniprot id: A8H777
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

398579:SPEA RS06175
gene id: 398579:SPEA_RS06175
uniprot id: A8H1S2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

398579:SPEA RS03195
gene id: 398579:SPEA_RS03195
uniprot id: A8H042
names: Similarity
messages: Belongs to the EndA/NucM nuclease family.

398579:SPEA RS04830
gene id: 398579:SPEA_RS04830
uniprot id: A8H113
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

398579:SPEA RS19180
gene id: 398579:SPEA_RS19180
uniprot id: A8H8S1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

398579:SPEA RS09440
gene id: 398579:SPEA_RS09440
uniprot id: A8H3I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

398579:SPEA RS10180
gene id: 398579:SPEA_RS10180
uniprot id: A8H3Y0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

398579:SPEA RS12030
gene id: 398579:SPEA_RS12030
uniprot id: A8H4W6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS01320
gene id: 398579:SPEA_RS01320
uniprot id: A8GZ30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

398579:SPEA RS15565
gene id: 398579:SPEA_RS15565
uniprot id: A8H6T0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

398579:SPEA RS16385
gene id: 398579:SPEA_RS16385
uniprot id: A8H792
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS00360
gene id: 398579:SPEA_RS00360
uniprot id: A8GYK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

398579:SPEA RS04825
gene id: 398579:SPEA_RS04825
uniprot id: A8H112
names: Similarity
messages: Belongs to the peptidase M24B family.

398579:SPEA RS11615
gene id: 398579:SPEA_RS11615
uniprot id: A8H4P7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

398579:SPEA RS20885
gene id: 398579:SPEA_RS20885
uniprot id: A8H9Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

398579:SPEA RS01240
gene id: 398579:SPEA_RS01240
uniprot id: A8GZ14
names: Similarity
messages: Belongs to the CinA family.

398579:SPEA RS04640
gene id: 398579:SPEA_RS04640
uniprot id: A8H0X5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

398579:SPEA RS01565
gene id: 398579:SPEA_RS01565
uniprot id: A8GZ79
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS20160
gene id: 398579:SPEA_RS20160
uniprot id: A8H9B0
names: Similarity
messages: Belongs to the UPF0758 family.

398579:SPEA RS07545
gene id: 398579:SPEA_RS07545
uniprot id: A8H2I4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

398579:SPEA RS02465
gene id: 398579:SPEA_RS02465
uniprot id: A8GZQ2
names: Similarity
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.

398579:SPEA RS16660
gene id: 398579:SPEA_RS16660
uniprot id: A8H7D4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

398579:SPEA RS18855
gene id: 398579:SPEA_RS18855
uniprot id: A8H8K8
names: Similarity
messages: Belongs to the peptidase S46 family.

398579:SPEA RS00630
gene id: 398579:SPEA_RS00630
uniprot id: A8GYR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane

398579:SPEA RS20770
gene id: 398579:SPEA_RS20770
uniprot id: A8H9N0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS13185
gene id: 398579:SPEA_RS13185
uniprot id: A8H5H6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

398579:SPEA RS11665
gene id: 398579:SPEA_RS11665
uniprot id: A8H4Q7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

398579:SPEA RS19680
gene id: 398579:SPEA_RS19680
uniprot id: A8H920
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

398579:SPEA RS02125
gene id: 398579:SPEA_RS02125
uniprot id: A8GZI7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS18000
gene id: 398579:SPEA_RS18000
uniprot id: A8H845
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS22275
gene id: 398579:SPEA_RS22275
uniprot id: A8HAG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

398579:SPEA RS04465
gene id: 398579:SPEA_RS04465
uniprot id: A8H0U2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

398579:SPEA RS13400
gene id: 398579:SPEA_RS13400
uniprot id: A8H5L7
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS15145
gene id: 398579:SPEA_RS15145
uniprot id: A8H6J8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

398579:SPEA RS00990
gene id: 398579:SPEA_RS00990
uniprot id: A8GYX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

398579:SPEA RS02975
gene id: 398579:SPEA_RS02975
uniprot id: A8GZZ7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS02700
gene id: 398579:SPEA_RS02700
uniprot id: A8GZU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

398579:SPEA RS21300
gene id: 398579:SPEA_RS21300
uniprot id: A8H9Y3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS18560
gene id: 398579:SPEA_RS18560
uniprot id: A8H8F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

398579:SPEA RS00805
gene id: 398579:SPEA_RS00805
uniprot id: A8GYU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP M family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

398579:SPEA RS04815
gene id: 398579:SPEA_RS04815
uniprot id: A8H110
names: Similarity
messages: Belongs to the peptidase M24B family.

398579:SPEA RS16255
gene id: 398579:SPEA_RS16255
uniprot id: A8H765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

398579:SPEA RS21875
gene id: 398579:SPEA_RS21875
uniprot id: A8HA94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

398579:SPEA RS05715
gene id: 398579:SPEA_RS05715
uniprot id: A8H1I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS21080
gene id: 398579:SPEA_RS21080
uniprot id: A8H9T9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

398579:SPEA RS20765
gene id: 398579:SPEA_RS20765
uniprot id: A8H9M9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS12985
gene id: 398579:SPEA_RS12985
uniprot id: A8H5D6
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

398579:SPEA RS21065
gene id: 398579:SPEA_RS21065
uniprot id: A8H9T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
messages: Cytoplasm
messages: Monomer.
messages: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

398579:SPEA RS13345
gene id: 398579:SPEA_RS13345
uniprot id: A8H5K6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

398579:SPEA RS07070
gene id: 398579:SPEA_RS07070
uniprot id: A8H290
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

398579:SPEA RS08490
gene id: 398579:SPEA_RS08490
uniprot id: A8H301
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS18450
gene id: 398579:SPEA_RS18450
uniprot id: A8H8D3
names: Similarity
messages: Belongs to the phosphoribulokinase family.

398579:SPEA RS11765
gene id: 398579:SPEA_RS11765
uniprot id: A8H4S6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

398579:SPEA RS05640
gene id: 398579:SPEA_RS05640
uniprot id: A8H1H2
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

398579:SPEA RS03210
gene id: 398579:SPEA_RS03210
uniprot id: A8H045
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS20060
gene id: 398579:SPEA_RS20060
uniprot id: A8H990
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

398579:SPEA RS13035
gene id: 398579:SPEA_RS13035
uniprot id: A8H5E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

398579:SPEA RS15665
gene id: 398579:SPEA_RS15665
uniprot id: A8H6U9
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

398579:SPEA RS11720
gene id: 398579:SPEA_RS11720
uniprot id: A8H4R8
names: Similarity
messages: Belongs to the AlaDH/PNT family.

398579:SPEA RS10845
gene id: 398579:SPEA_RS10845
uniprot id: A8H4A3
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

398579:SPEA RS17885
gene id: 398579:SPEA_RS17885
uniprot id: A8H822
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS03500
gene id: 398579:SPEA_RS03500
uniprot id: A8H0A1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
messages: Membrane

398579:SPEA RS03690
gene id: 398579:SPEA_RS03690
uniprot id: A8H0D9
names: Similarity
messages: Belongs to the SfsA family.

398579:SPEA RS17795
gene id: 398579:SPEA_RS17795
uniprot id: A8H803
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

398579:SPEA RS20230
gene id: 398579:SPEA_RS20230
uniprot id: A8H9C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

398579:SPEA RS16425
gene id: 398579:SPEA_RS16425
uniprot id: A8H7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

398579:SPEA RS13895
gene id: 398579:SPEA_RS13895
uniprot id: A8H5V6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS01050
gene id: 398579:SPEA_RS01050
uniprot id: A8GYY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

398579:SPEA RS21115
gene id: 398579:SPEA_RS21115
uniprot id: A8H9U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

398579:SPEA RS03710
gene id: 398579:SPEA_RS03710
uniprot id: A8H0E3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

398579:SPEA RS16630
gene id: 398579:SPEA_RS16630
uniprot id: A8H7C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

398579:SPEA RS00680
gene id: 398579:SPEA_RS00680
uniprot id: A8GYS0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

398579:SPEA RS04700
gene id: 398579:SPEA_RS04700
uniprot id: A8H0Y7
names: Similarity
messages: Belongs to the MEMO1 family.

398579:SPEA RS19405
gene id: 398579:SPEA_RS19405
uniprot id: A8H8W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

398579:SPEA RS00535
gene id: 398579:SPEA_RS00535
uniprot id: A8GYP0
names: Function
names: Similarity
names: Subunit
messages: A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
messages: Belongs to the YihI family.
messages: Interacts with Der.

398579:SPEA RS12395
gene id: 398579:SPEA_RS12395
uniprot id: A8H531
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS00740
gene id: 398579:SPEA_RS00740
uniprot id: A8GYT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Monomer.

398579:SPEA RS19470
gene id: 398579:SPEA_RS19470
uniprot id: A8H8X7
names: Similarity
messages: Belongs to the PhoH family.

398579:SPEA RS17480
gene id: 398579:SPEA_RS17480
uniprot id: A8H7U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

398579:SPEA RS06320
gene id: 398579:SPEA_RS06320
uniprot id: A8H1U1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS15775
gene id: 398579:SPEA_RS15775
uniprot id: A8H6X1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

398579:SPEA RS07870
gene id: 398579:SPEA_RS07870
uniprot id: A8H2M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS00410
gene id: 398579:SPEA_RS00410
uniprot id: A8GYL5
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

398579:SPEA RS12605
gene id: 398579:SPEA_RS12605
uniprot id: A8H565
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS06390
gene id: 398579:SPEA_RS06390
uniprot id: A8H1V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides.

398579:SPEA RS12885
gene id: 398579:SPEA_RS12885
uniprot id: A8H5B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
messages: Cell inner membrane
messages: Homotetramer.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

398579:SPEA RS18115
gene id: 398579:SPEA_RS18115
uniprot id: A8H867
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

398579:SPEA RS21145
gene id: 398579:SPEA_RS21145
uniprot id: A8H9V2
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS07275
gene id: 398579:SPEA_RS07275
uniprot id: A8H2D0
names: Similarity
messages: Belongs to the MlaA family.

398579:SPEA RS19935
gene id: 398579:SPEA_RS19935
uniprot id: A8H971
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

398579:SPEA RS01145
gene id: 398579:SPEA_RS01145
uniprot id: A8GZ04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

398579:SPEA RS07005
gene id: 398579:SPEA_RS07005
uniprot id: A8H277
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

398579:SPEA RS01315
gene id: 398579:SPEA_RS01315
uniprot id: A8GZ29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS14065
gene id: 398579:SPEA_RS14065
uniprot id: A8H5Y9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and 5'-3' DNA helicase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS22200
gene id: 398579:SPEA_RS22200
uniprot id: A8HAF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS20185
gene id: 398579:SPEA_RS20185
uniprot id: A8H9B5
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

398579:SPEA RS03005
gene id: 398579:SPEA_RS03005
uniprot id: A8H003
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

398579:SPEA RS00915
gene id: 398579:SPEA_RS00915
uniprot id: A8GYW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

398579:SPEA RS04055
gene id: 398579:SPEA_RS04055
uniprot id: A8H0L0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

398579:SPEA RS13415
gene id: 398579:SPEA_RS13415
uniprot id: A8H5M0
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

398579:SPEA RS08615
gene id: 398579:SPEA_RS08615
uniprot id: A8H326
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

398579:SPEA RS00445
gene id: 398579:SPEA_RS00445
uniprot id: A8GYM2
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS19660
gene id: 398579:SPEA_RS19660
uniprot id: A8H916
names: Similarity
messages: Belongs to the intimin/invasin family.

398579:SPEA RS16065
gene id: 398579:SPEA_RS16065
uniprot id: A8H729
names: Similarity
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.

398579:SPEA RS09355
gene id: 398579:SPEA_RS09355
uniprot id: A8H3G9
names: Similarity
messages: Belongs to the citrate synthase family.

398579:SPEA RS05980
gene id: 398579:SPEA_RS05980
uniprot id: A8H1N4
names: Similarity
messages: Belongs to the alkaline phosphatase family.

398579:SPEA RS21140
gene id: 398579:SPEA_RS21140
uniprot id: A8H9V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

398579:SPEA RS13445
gene id: 398579:SPEA_RS13445
uniprot id: A8H5M6
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

398579:SPEA RS13610
gene id: 398579:SPEA_RS13610
uniprot id: A8H5P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

398579:SPEA RS22245
gene id: 398579:SPEA_RS22245
uniprot id: A8HAG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

398579:SPEA RS05090
gene id: 398579:SPEA_RS05090
uniprot id: A8H164
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS17305
gene id: 398579:SPEA_RS17305
uniprot id: A8H7Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS16340
gene id: 398579:SPEA_RS16340
uniprot id: A8H783
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

398579:SPEA RS13975
gene id: 398579:SPEA_RS13975
uniprot id: A8H5X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS05400
gene id: 398579:SPEA_RS05400
uniprot id: A8H1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

398579:SPEA RS01010
gene id: 398579:SPEA_RS01010
uniprot id: A8GYX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

398579:SPEA RS01255
gene id: 398579:SPEA_RS01255
uniprot id: A8GZ17
names: Similarity
messages: Belongs to the peptidase M20A family. ArgE subfamily.

398579:SPEA RS16070
gene id: 398579:SPEA_RS16070
uniprot id: A8H730
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS07135
gene id: 398579:SPEA_RS07135
uniprot id: A8H2A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

398579:SPEA RS12955
gene id: 398579:SPEA_RS12955
uniprot id: A8H5D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

398579:SPEA RS15175
gene id: 398579:SPEA_RS15175
uniprot id: A8H6K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

398579:SPEA RS15660
gene id: 398579:SPEA_RS15660
uniprot id: A8H6U8
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

398579:SPEA RS20665
gene id: 398579:SPEA_RS20665
uniprot id: A8H9K9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS20470
gene id: 398579:SPEA_RS20470
uniprot id: A8H9H0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS10325
gene id: 398579:SPEA_RS10325
uniprot id: A8H402
names: Similarity
messages: Belongs to the DnaA family.

398579:SPEA RS10295
gene id: 398579:SPEA_RS10295
uniprot id: A8H3Z6
names: Similarity
messages: Belongs to the UPF0229 family.

398579:SPEA RS05095
gene id: 398579:SPEA_RS05095
uniprot id: A8H165
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

398579:SPEA RS12405
gene id: 398579:SPEA_RS12405
uniprot id: A8H533
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS12825
gene id: 398579:SPEA_RS12825
uniprot id: A8H5A4
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

398579:SPEA RS07105
gene id: 398579:SPEA_RS07105
uniprot id: A8H296
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

398579:SPEA RS12860
gene id: 398579:SPEA_RS12860
uniprot id: A8H5B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

398579:SPEA RS06820
gene id: 398579:SPEA_RS06820
uniprot id: A8H242
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

398579:SPEA RS15530
gene id: 398579:SPEA_RS15530
uniprot id: A8H6S3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

398579:SPEA RS01390
gene id: 398579:SPEA_RS01390
uniprot id: A8GZ44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

398579:SPEA RS10625
gene id: 398579:SPEA_RS10625
uniprot id: A8H459
names: Similarity
messages: Belongs to the HupF/HypC family.

398579:SPEA RS07745
gene id: 398579:SPEA_RS07745
uniprot id: A8H2J8
names: Similarity
messages: Belongs to the DEAD box helicase family.

398579:SPEA RS02385
gene id: 398579:SPEA_RS02385
uniprot id: A8GZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

398579:SPEA RS10285
gene id: 398579:SPEA_RS10285
uniprot id: A8H3Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

398579:SPEA RS11340
gene id: 398579:SPEA_RS11340
uniprot id: A8H4J3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS07550
gene id: 398579:SPEA_RS07550
uniprot id: A8H2I5
names: Similarity
messages: Belongs to the UDPGP type 2 family.

398579:SPEA RS05865
gene id: 398579:SPEA_RS05865
uniprot id: A8H1L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

398579:SPEA RS09035
gene id: 398579:SPEA_RS09035
uniprot id: A8H3A4
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

398579:SPEA RS02510
gene id: 398579:SPEA_RS02510
uniprot id: A8GZR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

398579:SPEA RS08550
gene id: 398579:SPEA_RS08550
uniprot id: A8H313
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

398579:SPEA RS02870
gene id: 398579:SPEA_RS02870
uniprot id: A8GZX6
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

398579:SPEA RS06220
gene id: 398579:SPEA_RS06220
uniprot id: A8H1T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

398579:SPEA RS20530
gene id: 398579:SPEA_RS20530
uniprot id: A8H9I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell inner membrane

398579:SPEA RS09445
gene id: 398579:SPEA_RS09445
uniprot id: A8H3I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS03230
gene id: 398579:SPEA_RS03230
uniprot id: A8H049
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

398579:SPEA RS05610
gene id: 398579:SPEA_RS05610
uniprot id: A8H1G6
names: Similarity
messages: Belongs to the XFP family.

398579:SPEA RS05420
gene id: 398579:SPEA_RS05420
uniprot id: A8H1C9
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

398579:SPEA RS13215
gene id: 398579:SPEA_RS13215
uniprot id: A8H5I2
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

398579:SPEA RS13495
gene id: 398579:SPEA_RS13495
uniprot id: A8H5N6
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

398579:SPEA RS05415
gene id: 398579:SPEA_RS05415
uniprot id: A8H1C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS20640
gene id: 398579:SPEA_RS20640
uniprot id: A8H9K4
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS08460
gene id: 398579:SPEA_RS08460
uniprot id: A8H2Z6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS20195
gene id: 398579:SPEA_RS20195
uniprot id: A8H9B7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

398579:SPEA RS07585
gene id: 398579:SPEA_RS07585
uniprot id: A8H2J2
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS06995
gene id: 398579:SPEA_RS06995
uniprot id: A8H275
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

398579:SPEA RS09870
gene id: 398579:SPEA_RS09870
uniprot id: A8H3R7
names: Subcellular Location Annotation
messages: Cell inner membrane

398579:SPEA RS10350
gene id: 398579:SPEA_RS10350
uniprot id: A8H407
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

398579:SPEA RS03185
gene id: 398579:SPEA_RS03185
uniprot id: A8H040
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

398579:SPEA RS10740
gene id: 398579:SPEA_RS10740
uniprot id: A8H482
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

398579:SPEA RS20565
gene id: 398579:SPEA_RS20565
uniprot id: A8H9I9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

398579:SPEA RS05960
gene id: 398579:SPEA_RS05960
uniprot id: A8H1N0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

398579:SPEA RS19690
gene id: 398579:SPEA_RS19690
uniprot id: A8H922
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

398579:SPEA RS16455
gene id: 398579:SPEA_RS16455
uniprot id: A8H7A6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

398579:SPEA RS10305
gene id: 398579:SPEA_RS10305
uniprot id: A8H3Z8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

398579:SPEA RS10600
gene id: 398579:SPEA_RS10600
uniprot id: A8H454
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS22065
gene id: 398579:SPEA_RS22065
uniprot id: A8HAD2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS17740
gene id: 398579:SPEA_RS17740
uniprot id: A8H7Z3
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS21395
gene id: 398579:SPEA_RS21395
uniprot id: A8HA02
names: Similarity
messages: Belongs to the RutC family.

398579:SPEA RS08170
gene id: 398579:SPEA_RS08170
uniprot id: A8H2T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

398579:SPEA RS08750
gene id: 398579:SPEA_RS08750
uniprot id: A8H350
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

398579:SPEA RS17545
gene id: 398579:SPEA_RS17545
uniprot id: A8H7V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS01090
gene id: 398579:SPEA_RS01090
uniprot id: A8GYZ3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

398579:SPEA RS20980
gene id: 398579:SPEA_RS20980
uniprot id: A8H9S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

398579:SPEA RS08060
gene id: 398579:SPEA_RS08060
uniprot id: A8H2R3
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

398579:SPEA RS05430
gene id: 398579:SPEA_RS05430
uniprot id: A8H1D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

398579:SPEA RS05030
gene id: 398579:SPEA_RS05030
uniprot id: A8H152
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

398579:SPEA RS21265
gene id: 398579:SPEA_RS21265
uniprot id: A8H9X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

398579:SPEA RS08310
gene id: 398579:SPEA_RS08310
uniprot id: A8H2W3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS10750
gene id: 398579:SPEA_RS10750
uniprot id: A8H484
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

398579:SPEA RS10170
gene id: 398579:SPEA_RS10170
uniprot id: A8H3X8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

398579:SPEA RS06235
gene id: 398579:SPEA_RS06235
uniprot id: A8H1T4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

398579:SPEA RS09095
gene id: 398579:SPEA_RS09095
uniprot id: A8H3B6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS13270
gene id: 398579:SPEA_RS13270
uniprot id: A8H5J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

398579:SPEA RS12235
gene id: 398579:SPEA_RS12235
uniprot id: A8H504
names: Similarity
messages: Belongs to the citrate synthase family.

398579:SPEA RS06200
gene id: 398579:SPEA_RS06200
uniprot id: A8H1S7
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

398579:SPEA RS05845
gene id: 398579:SPEA_RS05845
uniprot id: A8H1K7
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS00840
gene id: 398579:SPEA_RS00840
uniprot id: A8GYV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SelU family.
messages: Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
messages: Monomer.

398579:SPEA RS18015
gene id: 398579:SPEA_RS18015
uniprot id: A8H848
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS15815
gene id: 398579:SPEA_RS15815
uniprot id: A8H6X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

398579:SPEA RS11415
gene id: 398579:SPEA_RS11415
uniprot id: A8H4K8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

398579:SPEA RS20635
gene id: 398579:SPEA_RS20635
uniprot id: A8H9K3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

398579:SPEA RS11430
gene id: 398579:SPEA_RS11430
uniprot id: A8H4L1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS18910
gene id: 398579:SPEA_RS18910
uniprot id: A8H8L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

398579:SPEA RS00415
gene id: 398579:SPEA_RS00415
uniprot id: A8GYL6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

398579:SPEA RS20430
gene id: 398579:SPEA_RS20430
uniprot id: A8H9G2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

398579:SPEA RS16390
gene id: 398579:SPEA_RS16390
uniprot id: A8H793
names: Similarity
messages: Belongs to the UPF0234 family.

398579:SPEA RS20145
gene id: 398579:SPEA_RS20145
uniprot id: A8H9A7
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

398579:SPEA RS08305
gene id: 398579:SPEA_RS08305
uniprot id: A8H2W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS16850
gene id: 398579:SPEA_RS16850
uniprot id: A8H7G5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.
messages: Homotetramer.

398579:SPEA RS09610
gene id: 398579:SPEA_RS09610
uniprot id: A8H3L9
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

398579:SPEA RS13205
gene id: 398579:SPEA_RS13205
uniprot id: A8H5I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

398579:SPEA RS21225
gene id: 398579:SPEA_RS21225
uniprot id: A8H9W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

398579:SPEA RS16005
gene id: 398579:SPEA_RS16005
uniprot id: A8H717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

398579:SPEA RS22175
gene id: 398579:SPEA_RS22175
uniprot id: A8HAE8
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS01520
gene id: 398579:SPEA_RS01520
uniprot id: A8GZ70
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

398579:SPEA RS21840
gene id: 398579:SPEA_RS21840
uniprot id: A8HA87
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

398579:SPEA RS00485
gene id: 398579:SPEA_RS00485
uniprot id: A8GYN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

398579:SPEA RS19500
gene id: 398579:SPEA_RS19500
uniprot id: A8H8Y3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

398579:SPEA RS02675
gene id: 398579:SPEA_RS02675
uniprot id: A8GZU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multiheme cytochrome c family.
messages: Binds 8 heme c groups covalently per monomer.
messages: Exposure to oxygen reduces copper binding and leads to the formation of a disulfide bond between the two Cys residues that bind the copper ion.
messages: Periplasm
messages: Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process.

398579:SPEA RS22190
gene id: 398579:SPEA_RS22190
uniprot id: A8HAF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

398579:SPEA RS09525
gene id: 398579:SPEA_RS09525
uniprot id: A8H3K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Fimbrium

398579:SPEA RS00945
gene id: 398579:SPEA_RS00945
uniprot id: A8GYW4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

398579:SPEA RS02790
gene id: 398579:SPEA_RS02790
uniprot id: A8GZW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Membrane

398579:SPEA RS20070
gene id: 398579:SPEA_RS20070
uniprot id: A8H992
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

398579:SPEA RS10000
gene id: 398579:SPEA_RS10000
uniprot id: A8H3U4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

398579:SPEA RS01675
gene id: 398579:SPEA_RS01675
uniprot id: A8GZA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS16045
gene id: 398579:SPEA_RS16045
uniprot id: A8H725
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

398579:SPEA RS03625
gene id: 398579:SPEA_RS03625
uniprot id: A8H0C6
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

398579:SPEA RS21445
gene id: 398579:SPEA_RS21445
uniprot id: A8HA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS16185
gene id: 398579:SPEA_RS16185
uniprot id: A8H751
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

398579:SPEA RS08955
gene id: 398579:SPEA_RS08955
uniprot id: A8H392
names: Function
names: Similarity
messages: Belongs to the proline racemase family.
messages: In vitro, catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C), albeit with very low efficiency. The physiological substrate may be different. Displays neither trans-4-hydroxy-L-proline (t4LHyp) epimerase nor proline racemase activity.

398579:SPEA RS22230
gene id: 398579:SPEA_RS22230
uniprot id: A8HAF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS18805
gene id: 398579:SPEA_RS18805
uniprot id: A8H8J8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS14050
gene id: 398579:SPEA_RS14050
uniprot id: A8H5Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS13210
gene id: 398579:SPEA_RS13210
uniprot id: A8H5I1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

398579:SPEA RS03770
gene id: 398579:SPEA_RS03770
uniprot id: A8H0F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS07875
gene id: 398579:SPEA_RS07875
uniprot id: A8H2M4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

398579:SPEA RS13040
gene id: 398579:SPEA_RS13040
uniprot id: A8H5E6
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

398579:SPEA RS11710
gene id: 398579:SPEA_RS11710
uniprot id: A8H4R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

398579:SPEA RS00215
gene id: 398579:SPEA_RS00215
uniprot id: A8GYI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

398579:SPEA RS15325
gene id: 398579:SPEA_RS15325
uniprot id: A8H6N4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS18440
gene id: 398579:SPEA_RS18440
uniprot id: A8H8D1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

398579:SPEA RS03075
gene id: 398579:SPEA_RS03075
uniprot id: A8H017
names: Similarity
messages: Belongs to the aldose epimerase family.

398579:SPEA RS20875
gene id: 398579:SPEA_RS20875
uniprot id: A8H9Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

398579:SPEA RS12230
gene id: 398579:SPEA_RS12230
uniprot id: A8H503
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

398579:SPEA RS17430
gene id: 398579:SPEA_RS17430
uniprot id: A8H7T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

398579:SPEA RS01115
gene id: 398579:SPEA_RS01115
uniprot id: A8GYZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

398579:SPEA RS05470
gene id: 398579:SPEA_RS05470
uniprot id: A8H1D9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

398579:SPEA RS19870
gene id: 398579:SPEA_RS19870
uniprot id: A8H958
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

398579:SPEA RS08280
gene id: 398579:SPEA_RS08280
uniprot id: A8H2V7
names: Similarity
messages: Belongs to the universal stress protein A family.

398579:SPEA RS17335
gene id: 398579:SPEA_RS17335
uniprot id: A8H7R3
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS01350
gene id: 398579:SPEA_RS01350
uniprot id: A8GZ36
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

398579:SPEA RS07180
gene id: 398579:SPEA_RS07180
uniprot id: A8H2B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

398579:SPEA RS05380
gene id: 398579:SPEA_RS05380
uniprot id: A8H1C1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

398579:SPEA RS03040
gene id: 398579:SPEA_RS03040
uniprot id: A8H010
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

398579:SPEA RS20995
gene id: 398579:SPEA_RS20995
uniprot id: A8H9S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

398579:SPEA RS11770
gene id: 398579:SPEA_RS11770
uniprot id: A8H4S7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

398579:SPEA RS13060
gene id: 398579:SPEA_RS13060
uniprot id: A8H5F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.
messages: Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A.
messages: Cell inner membrane

398579:SPEA RS07145
gene id: 398579:SPEA_RS07145
uniprot id: A8H2A4
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS16295
gene id: 398579:SPEA_RS16295
uniprot id: A8H774
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

398579:SPEA RS01680
gene id: 398579:SPEA_RS01680
uniprot id: A8GZA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

398579:SPEA RS08025
gene id: 398579:SPEA_RS08025
uniprot id: A8H2Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

398579:SPEA RS16330
gene id: 398579:SPEA_RS16330
uniprot id: A8H781
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS04720
gene id: 398579:SPEA_RS04720
uniprot id: A8H0Z1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

398579:SPEA RS20680
gene id: 398579:SPEA_RS20680
uniprot id: A8H9L2
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

398579:SPEA RS02475
gene id: 398579:SPEA_RS02475
uniprot id: A8GZQ4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

398579:SPEA RS17890
gene id: 398579:SPEA_RS17890
uniprot id: A8H823
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

398579:SPEA RS12460
gene id: 398579:SPEA_RS12460
uniprot id: A8H536
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

398579:SPEA RS00020
gene id: 398579:SPEA_RS00020
uniprot id: A8GYE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

398579:SPEA RS10230
gene id: 398579:SPEA_RS10230
uniprot id: A8H3Y7
names: Similarity
messages: Belongs to the peptidase S16 family.

398579:SPEA RS21595
gene id: 398579:SPEA_RS21595
uniprot id: A8HA39
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

398579:SPEA RS05645
gene id: 398579:SPEA_RS05645
uniprot id: A8H1H3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

398579:SPEA RS08810
gene id: 398579:SPEA_RS08810
uniprot id: A8H362
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS06840
gene id: 398579:SPEA_RS06840
uniprot id: A8H246
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS15455
gene id: 398579:SPEA_RS15455
uniprot id: A8H6Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

398579:SPEA RS18925
gene id: 398579:SPEA_RS18925
uniprot id: A8H8M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

398579:SPEA RS09455
gene id: 398579:SPEA_RS09455
uniprot id: A8H3I8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

398579:SPEA RS17620
gene id: 398579:SPEA_RS17620
uniprot id: A8H7X0
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TorC/TorY family.
messages: Binds 5 heme groups per subunit.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS09400
gene id: 398579:SPEA_RS09400
uniprot id: A8H3H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

398579:SPEA RS16460
gene id: 398579:SPEA_RS16460
uniprot id: A8H7A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.
messages: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.

398579:SPEA RS08445
gene id: 398579:SPEA_RS08445
uniprot id: A8H2Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

398579:SPEA RS12785
gene id: 398579:SPEA_RS12785
uniprot id: A8H596
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Periplasm

398579:SPEA RS00810
gene id: 398579:SPEA_RS00810
uniprot id: A8GYU6
names: Similarity
messages: Belongs to the GSP N family.

398579:SPEA RS19240
gene id: 398579:SPEA_RS19240
uniprot id: A8H8T3
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS07560
gene id: 398579:SPEA_RS07560
uniprot id: A8H2I7
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

398579:SPEA RS01105
gene id: 398579:SPEA_RS01105
uniprot id: A8GYZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

398579:SPEA RS06315
gene id: 398579:SPEA_RS06315
uniprot id: A8H1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

398579:SPEA RS10040
gene id: 398579:SPEA_RS10040
uniprot id: A8H3V2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

398579:SPEA RS11115
gene id: 398579:SPEA_RS11115
uniprot id: A8H4E9
names: Similarity
messages: Belongs to the 4-hydroxy-2-oxovalerate aldolase family.

398579:SPEA RS03355
gene id: 398579:SPEA_RS03355
uniprot id: A8H075
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS09270
gene id: 398579:SPEA_RS09270
uniprot id: A8H3F0
names: Similarity
messages: Belongs to the UPF0352 family.

398579:SPEA RS18640
gene id: 398579:SPEA_RS18640
uniprot id: A8H8H1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS00465
gene id: 398579:SPEA_RS00465
uniprot id: A8GYM6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

398579:SPEA RS16115
gene id: 398579:SPEA_RS16115
uniprot id: A8H739
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

398579:SPEA RS00985
gene id: 398579:SPEA_RS00985
uniprot id: A8GYX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

398579:SPEA RS16260
gene id: 398579:SPEA_RS16260
uniprot id: A8H766
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

398579:SPEA RS00500
gene id: 398579:SPEA_RS00500
uniprot id: A8GYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

398579:SPEA RS09765
gene id: 398579:SPEA_RS09765
uniprot id: A8H3P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

398579:SPEA RS04230
gene id: 398579:SPEA_RS04230
uniprot id: A8H0P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

398579:SPEA RS12095
gene id: 398579:SPEA_RS12095
uniprot id: A8H4X8
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.

398579:SPEA RS22260
gene id: 398579:SPEA_RS22260
uniprot id: A8HAG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

398579:SPEA RS13025
gene id: 398579:SPEA_RS13025
uniprot id: A8H5E3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

398579:SPEA RS10810
gene id: 398579:SPEA_RS10810
uniprot id: A8H496
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

398579:SPEA RS06720
gene id: 398579:SPEA_RS06720
uniprot id: A8H222
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

398579:SPEA RS01175
gene id: 398579:SPEA_RS01175
uniprot id: A8GZ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

398579:SPEA RS16210
gene id: 398579:SPEA_RS16210
uniprot id: A8H756
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

398579:SPEA RS16740
gene id: 398579:SPEA_RS16740
uniprot id: A8H7E4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

398579:SPEA RS11745
gene id: 398579:SPEA_RS11745
uniprot id: A8H4S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS04920
gene id: 398579:SPEA_RS04920
uniprot id: A8H131
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

398579:SPEA RS07045
gene id: 398579:SPEA_RS07045
uniprot id: A8H285
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

398579:SPEA RS12905
gene id: 398579:SPEA_RS12905
uniprot id: A8H5C0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS21280
gene id: 398579:SPEA_RS21280
uniprot id: A8H9X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

398579:SPEA RS11120
gene id: 398579:SPEA_RS11120
uniprot id: A8H4F0
names: Similarity
messages: Belongs to the acetaldehyde dehydrogenase family.

398579:SPEA RS17345
gene id: 398579:SPEA_RS17345
uniprot id: A8H7R5
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS18970
gene id: 398579:SPEA_RS18970
uniprot id: A8H8N0
names: Similarity
messages: Belongs to the BolA/IbaG family.

398579:SPEA RS05635
gene id: 398579:SPEA_RS05635
uniprot id: A8H1H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

398579:SPEA RS20805
gene id: 398579:SPEA_RS20805
uniprot id: A8H9N7
names: Subcellular Location Annotation
messages: Periplasm

398579:SPEA RS05425
gene id: 398579:SPEA_RS05425
uniprot id: A8H1D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

398579:SPEA RS16960
gene id: 398579:SPEA_RS16960
uniprot id: A8H7I8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS10010
gene id: 398579:SPEA_RS10010
uniprot id: A8H3U6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

398579:SPEA RS12630
gene id: 398579:SPEA_RS12630
uniprot id: A8H570
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

398579:SPEA RS01980
gene id: 398579:SPEA_RS01980
uniprot id: A8GZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

398579:SPEA RS01375
gene id: 398579:SPEA_RS01375
uniprot id: A8GZ41
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

398579:SPEA RS02355
gene id: 398579:SPEA_RS02355
uniprot id: A8GZN0
names: Cofactor
names: Function
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.

398579:SPEA RS13280
gene id: 398579:SPEA_RS13280
uniprot id: A8H5J3
names: Similarity
messages: Belongs to the nitroreductase family.

398579:SPEA RS07195
gene id: 398579:SPEA_RS07195
uniprot id: A8H2B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

398579:SPEA RS21150
gene id: 398579:SPEA_RS21150
uniprot id: A8H9V3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS11135
gene id: 398579:SPEA_RS11135
uniprot id: A8H4F3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

398579:SPEA RS09250
gene id: 398579:SPEA_RS09250
uniprot id: A8H3E7
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS16745
gene id: 398579:SPEA_RS16745
uniprot id: A8H7E5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

398579:SPEA RS02460
gene id: 398579:SPEA_RS02460
uniprot id: A8GZQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

398579:SPEA RS13430
gene id: 398579:SPEA_RS13430
uniprot id: A8H5M3
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

398579:SPEA RS03300
gene id: 398579:SPEA_RS03300
uniprot id: A8H064
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

398579:SPEA RS01355
gene id: 398579:SPEA_RS01355
uniprot id: A8GZ37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS19550
gene id: 398579:SPEA_RS19550
uniprot id: A8H8Z4
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

398579:SPEA RS04375
gene id: 398579:SPEA_RS04375
uniprot id: A8H0S3
names: Similarity
messages: Belongs to the P(II) protein family.

398579:SPEA RS19920
gene id: 398579:SPEA_RS19920
uniprot id: A8H968
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell inner membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.

398579:SPEA RS00115
gene id: 398579:SPEA_RS00115
uniprot id: A8GYG2
names: Similarity
messages: Belongs to the IMPACT family.

398579:SPEA RS06735
gene id: 398579:SPEA_RS06735
uniprot id: A8H225
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

398579:SPEA RS10415
gene id: 398579:SPEA_RS10415
uniprot id: A8H420
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus.
messages: Belongs to the KdsB family.
messages: Cytoplasm

398579:SPEA RS04005
gene id: 398579:SPEA_RS04005
uniprot id: A8H0K0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS16825
gene id: 398579:SPEA_RS16825
uniprot id: A8H7G0
names: Similarity
messages: Belongs to the GST superfamily.

398579:SPEA RS14110
gene id: 398579:SPEA_RS14110
uniprot id: A8H5Z7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

398579:SPEA RS05855
gene id: 398579:SPEA_RS05855
uniprot id: A8H1K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS13125
gene id: 398579:SPEA_RS13125
uniprot id: A8H5G4
names: Similarity
messages: Belongs to the CvfB family.

398579:SPEA RS17560
gene id: 398579:SPEA_RS17560
uniprot id: A8H7V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

398579:SPEA RS05500
gene id: 398579:SPEA_RS05500
uniprot id: A8H1E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

398579:SPEA RS14535
gene id: 398579:SPEA_RS14535
uniprot id: A8H679
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS17465
gene id: 398579:SPEA_RS17465
uniprot id: A8H7T9
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

398579:SPEA RS00185
gene id: 398579:SPEA_RS00185
uniprot id: A8GYH6
names: Similarity
messages: Belongs to the Smg family.

398579:SPEA RS05940
gene id: 398579:SPEA_RS05940
uniprot id: A8H1M6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS05895
gene id: 398579:SPEA_RS05895
uniprot id: A8H1L7
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

398579:SPEA RS11660
gene id: 398579:SPEA_RS11660
uniprot id: A8H4Q6
names: Similarity
messages: Belongs to the universal stress protein A family.

398579:SPEA RS10395
gene id: 398579:SPEA_RS10395
uniprot id: A8H416
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamC family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

398579:SPEA RS14030
gene id: 398579:SPEA_RS14030
uniprot id: A8H5Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

398579:SPEA RS03395
gene id: 398579:SPEA_RS03395
uniprot id: A8H082
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

398579:SPEA RS06335
gene id: 398579:SPEA_RS06335
uniprot id: A8H1U4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.

398579:SPEA RS10705
gene id: 398579:SPEA_RS10705
uniprot id: A8H475
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS07395
gene id: 398579:SPEA_RS07395
uniprot id: A8H2F4
names: Similarity
messages: Belongs to the polysaccharide synthase family.

398579:SPEA RS00110
gene id: 398579:SPEA_RS00110
uniprot id: A8GYG1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Splits dipeptides with a prolyl residue in the C-terminal position.

398579:SPEA RS18870
gene id: 398579:SPEA_RS18870
uniprot id: A8H8L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

398579:SPEA RS12490
gene id: 398579:SPEA_RS12490
uniprot id: A8H542
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

398579:SPEA RS07385
gene id: 398579:SPEA_RS07385
uniprot id: A8H2F2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

398579:SPEA RS08845
gene id: 398579:SPEA_RS08845
uniprot id: A8H370
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS18485
gene id: 398579:SPEA_RS18485
uniprot id: A8H8E0
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family. AstD subfamily.
messages: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.

398579:SPEA RS07810
gene id: 398579:SPEA_RS07810
uniprot id: A8H2L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

398579:SPEA RS21535
gene id: 398579:SPEA_RS21535
uniprot id: A8HA27
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

398579:SPEA RS10590
gene id: 398579:SPEA_RS10590
uniprot id: A8H452
names: Similarity
messages: Belongs to the GSP E family.

398579:SPEA RS06325
gene id: 398579:SPEA_RS06325
uniprot id: A8H1U2
names: Similarity
messages: Belongs to the agmatine deiminase family.

398579:SPEA RS15065
gene id: 398579:SPEA_RS15065
uniprot id: A8H6I2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

398579:SPEA RS04520
gene id: 398579:SPEA_RS04520
uniprot id: A8H0V3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

398579:SPEA RS05900
gene id: 398579:SPEA_RS05900
uniprot id: A8H1L8
names: Similarity
messages: Belongs to the GSP E family.

398579:SPEA RS01110
gene id: 398579:SPEA_RS01110
uniprot id: A8GYZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

398579:SPEA RS02025
gene id: 398579:SPEA_RS02025
uniprot id: A8GZG6
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

398579:SPEA RS09425
gene id: 398579:SPEA_RS09425
uniprot id: A8H3I2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS17150
gene id: 398579:SPEA_RS17150
uniprot id: A8H7M6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS16990
gene id: 398579:SPEA_RS16990
uniprot id: A8H7J4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

398579:SPEA RS01380
gene id: 398579:SPEA_RS01380
uniprot id: A8GZ42
names: Similarity
messages: Belongs to the UPF0102 family.

398579:SPEA RS16280
gene id: 398579:SPEA_RS16280
uniprot id: A8H771
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

398579:SPEA RS16215
gene id: 398579:SPEA_RS16215
uniprot id: A8H757
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

398579:SPEA RS12275
gene id: 398579:SPEA_RS12275
uniprot id: A8H512
names: Similarity
messages: Belongs to the protease inhibitor I11 (ecotin) family.

398579:SPEA RS06055
gene id: 398579:SPEA_RS06055
uniprot id: A8H1P9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

398579:SPEA RS01460
gene id: 398579:SPEA_RS01460
uniprot id: A8GZ58
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Gfa family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.

398579:SPEA RS04145
gene id: 398579:SPEA_RS04145
uniprot id: A8H0M8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

398579:SPEA RS11825
gene id: 398579:SPEA_RS11825
uniprot id: A8H4T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S49 family.
messages: Cell inner membrane

398579:SPEA RS12610
gene id: 398579:SPEA_RS12610
uniprot id: A8H566
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

398579:SPEA RS15215
gene id: 398579:SPEA_RS15215
uniprot id: A8H6L2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

398579:SPEA RS00420
gene id: 398579:SPEA_RS00420
uniprot id: A8GYL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

398579:SPEA RS08345
gene id: 398579:SPEA_RS08345
uniprot id: A8H2X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

398579:SPEA RS14670
gene id: 398579:SPEA_RS14670
uniprot id: A8H6A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

398579:SPEA RS20085
gene id: 398579:SPEA_RS20085
uniprot id: A8H995
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

398579:SPEA RS15655
gene id: 398579:SPEA_RS15655
uniprot id: A8H6U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

398579:SPEA RS15135
gene id: 398579:SPEA_RS15135
uniprot id: A8H6J6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS02865
gene id: 398579:SPEA_RS02865
uniprot id: A8GZX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

398579:SPEA RS13005
gene id: 398579:SPEA_RS13005
uniprot id: A8H5D9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

398579:SPEA RS12680
gene id: 398579:SPEA_RS12680
uniprot id: A8H580
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS16765
gene id: 398579:SPEA_RS16765
uniprot id: A8H7E8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

398579:SPEA RS13045
gene id: 398579:SPEA_RS13045
uniprot id: A8H5E7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

398579:SPEA RS10355
gene id: 398579:SPEA_RS10355
uniprot id: A8H408
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

398579:SPEA RS00595
gene id: 398579:SPEA_RS00595
uniprot id: A8GYQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. KdkA/RfaP family.
messages: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS14190
gene id: 398579:SPEA_RS14190
uniprot id: A8H613
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

398579:SPEA RS02740
gene id: 398579:SPEA_RS02740
uniprot id: A8GZV7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS15110
gene id: 398579:SPEA_RS15110
uniprot id: A8H6J1
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

398579:SPEA RS20555
gene id: 398579:SPEA_RS20555
uniprot id: A8H9I7
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS14255
gene id: 398579:SPEA_RS14255
uniprot id: A8H623
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

398579:SPEA RS06835
gene id: 398579:SPEA_RS06835
uniprot id: A8H245
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

398579:SPEA RS19475
gene id: 398579:SPEA_RS19475
uniprot id: A8H8X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
messages: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
messages: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.

398579:SPEA RS10560
gene id: 398579:SPEA_RS10560
uniprot id: A8H446
names: Similarity
messages: Belongs to the bacterial secretin family.

398579:SPEA RS20485
gene id: 398579:SPEA_RS20485
uniprot id: A8H9H3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

398579:SPEA RS03505
gene id: 398579:SPEA_RS03505
uniprot id: A8H0A2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

398579:SPEA RS01125
gene id: 398579:SPEA_RS01125
uniprot id: A8GZ00
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

398579:SPEA RS01065
gene id: 398579:SPEA_RS01065
uniprot id: A8GYY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

398579:SPEA RS13750
gene id: 398579:SPEA_RS13750
uniprot id: A8H5S5
names: Function
names: Similarity
messages: Belongs to the peptidase M16 family.
messages: Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.

398579:SPEA RS16050
gene id: 398579:SPEA_RS16050
uniprot id: A8H726
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

398579:SPEA RS05075
gene id: 398579:SPEA_RS05075
uniprot id: A8H161
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

398579:SPEA RS13065
gene id: 398579:SPEA_RS13065
uniprot id: A8H5F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

398579:SPEA RS13530
gene id: 398579:SPEA_RS13530
uniprot id: A8H5P3
names: Subunit
messages: Monomer.

398579:SPEA RS14115
gene id: 398579:SPEA_RS14115
uniprot id: A8H5Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS15125
gene id: 398579:SPEA_RS15125
uniprot id: A8H6J4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

398579:SPEA RS18690
gene id: 398579:SPEA_RS18690
uniprot id: A8H8H5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

398579:SPEA RS13020
gene id: 398579:SPEA_RS13020
uniprot id: A8H5E2
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.

398579:SPEA RS09465
gene id: 398579:SPEA_RS09465
uniprot id: A8H3J0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS14605
gene id: 398579:SPEA_RS14605
uniprot id: A8H692
names: Similarity
messages: Belongs to the peptidase M17 family.

398579:SPEA RS00845
gene id: 398579:SPEA_RS00845
uniprot id: A8GYV3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

398579:SPEA RS13420
gene id: 398579:SPEA_RS13420
uniprot id: A8H5M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

398579:SPEA RS00460
gene id: 398579:SPEA_RS00460
uniprot id: A8GYM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

398579:SPEA RS15770
gene id: 398579:SPEA_RS15770
uniprot id: A8H6X0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

398579:SPEA RS10655
gene id: 398579:SPEA_RS10655
uniprot id: A8H465
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

398579:SPEA RS03895
gene id: 398579:SPEA_RS03895
uniprot id: A8H0H8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

398579:SPEA RS02990
gene id: 398579:SPEA_RS02990
uniprot id: A8H000
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MetJ family.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS08825
gene id: 398579:SPEA_RS08825
uniprot id: A8H366
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS21600
gene id: 398579:SPEA_RS21600
uniprot id: A8HA40
names: Similarity
messages: Belongs to the MoaD family.

398579:SPEA RS00975
gene id: 398579:SPEA_RS00975
uniprot id: A8GYX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

398579:SPEA RS05965
gene id: 398579:SPEA_RS05965
uniprot id: A8H1N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

398579:SPEA RS15740
gene id: 398579:SPEA_RS15740
uniprot id: A8H6W4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS17715
gene id: 398579:SPEA_RS17715
uniprot id: A8H7Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

398579:SPEA RS01170
gene id: 398579:SPEA_RS01170
uniprot id: A8GZ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS10440
gene id: 398579:SPEA_RS10440
uniprot id: A8H424
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

398579:SPEA RS13680
gene id: 398579:SPEA_RS13680
uniprot id: A8H5R1
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

398579:SPEA RS18030
gene id: 398579:SPEA_RS18030
uniprot id: A8H851
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS15750
gene id: 398579:SPEA_RS15750
uniprot id: A8H6W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

398579:SPEA RS15555
gene id: 398579:SPEA_RS15555
uniprot id: A8H6S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane

398579:SPEA RS16665
gene id: 398579:SPEA_RS16665
uniprot id: A8H7D5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

398579:SPEA RS10205
gene id: 398579:SPEA_RS10205
uniprot id: A8H3Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

398579:SPEA RS12830
gene id: 398579:SPEA_RS12830
uniprot id: A8H5A5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

398579:SPEA RS08360
gene id: 398579:SPEA_RS08360
uniprot id: A8H2X6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

398579:SPEA RS04835
gene id: 398579:SPEA_RS04835
uniprot id: A8H114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS17440
gene id: 398579:SPEA_RS17440
uniprot id: A8H7T3
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

398579:SPEA RS00435
gene id: 398579:SPEA_RS00435
uniprot id: A8GYM0
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

398579:SPEA RS07125
gene id: 398579:SPEA_RS07125
uniprot id: A8H2A0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

398579:SPEA RS21000
gene id: 398579:SPEA_RS21000
uniprot id: A8H9S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Cell inner membrane
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

398579:SPEA RS16315
gene id: 398579:SPEA_RS16315
uniprot id: A8H778
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS05630
gene id: 398579:SPEA_RS05630
uniprot id: A8H1H0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

398579:SPEA RS05455
gene id: 398579:SPEA_RS05455
uniprot id: A8H1D6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS12270
gene id: 398579:SPEA_RS12270
uniprot id: A8H511
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS02970
gene id: 398579:SPEA_RS02970
uniprot id: A8GZZ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

398579:SPEA RS07930
gene id: 398579:SPEA_RS07930
uniprot id: A8H2N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

398579:SPEA RS03860
gene id: 398579:SPEA_RS03860
uniprot id: A8H0H1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

398579:SPEA RS04140
gene id: 398579:SPEA_RS04140
uniprot id: A8H0M7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

398579:SPEA RS01870
gene id: 398579:SPEA_RS01870
uniprot id: A8GZD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

398579:SPEA RS08120
gene id: 398579:SPEA_RS08120
uniprot id: A8H2S5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS13030
gene id: 398579:SPEA_RS13030
uniprot id: A8H5E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

398579:SPEA RS16320
gene id: 398579:SPEA_RS16320
uniprot id: A8H779
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

398579:SPEA RS08515
gene id: 398579:SPEA_RS08515
uniprot id: A8H306
names: Function
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.
messages: Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

398579:SPEA RS10825
gene id: 398579:SPEA_RS10825
uniprot id: A8H499
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

398579:SPEA RS15950
gene id: 398579:SPEA_RS15950
uniprot id: A8H706
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

398579:SPEA RS01825
gene id: 398579:SPEA_RS01825
uniprot id: A8GZD0
names: Subcellular Location Annotation
messages: Periplasm

398579:SPEA RS05345
gene id: 398579:SPEA_RS05345
uniprot id: A8H1B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS21250
gene id: 398579:SPEA_RS21250
uniprot id: A8H9X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

398579:SPEA RS02445
gene id: 398579:SPEA_RS02445
uniprot id: A8GZP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

398579:SPEA RS13515
gene id: 398579:SPEA_RS13515
uniprot id: A8H5P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

398579:SPEA RS15670
gene id: 398579:SPEA_RS15670
uniprot id: A8H6V0
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

398579:SPEA RS20675
gene id: 398579:SPEA_RS20675
uniprot id: A8H9L1
names: Subcellular Location Annotation
messages: Periplasm

398579:SPEA RS13775
gene id: 398579:SPEA_RS13775
uniprot id: A8H5T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).

398579:SPEA RS13145
gene id: 398579:SPEA_RS13145
uniprot id: A8H5G8
names: Subcellular Location Annotation
messages: Cytoplasm

398579:SPEA RS06185
gene id: 398579:SPEA_RS06185
uniprot id: A8H1S4
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

398579:SPEA RS14770
gene id: 398579:SPEA_RS14770
uniprot id: A8H6C5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

398579:SPEA RS05270
gene id: 398579:SPEA_RS05270
uniprot id: A8H199
names: Function
messages: Repressor involved in choline regulation of the bet genes.
messages: Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine.

398579:SPEA RS20075
gene id: 398579:SPEA_RS20075
uniprot id: A8H993
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

398579:SPEA RS04530
gene id: 398579:SPEA_RS04530
uniprot id: A8H0V5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

398579:SPEA RS13070
gene id: 398579:SPEA_RS13070
uniprot id: A8H5F2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

398579:SPEA RS20465
gene id: 398579:SPEA_RS20465
uniprot id: A8H9G9
names: Subunit
messages: Monomer.

398579:SPEA RS00335
gene id: 398579:SPEA_RS00335
uniprot id: A8GYK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

398579:SPEA RS06125
gene id: 398579:SPEA_RS06125
uniprot id: A8H1R2
names: Similarity
messages: Belongs to the pirin family.

398579:SPEA RS10610
gene id: 398579:SPEA_RS10610
uniprot id: A8H456
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

398579:SPEA RS00395
gene id: 398579:SPEA_RS00395
uniprot id: A8GYL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

398579:SPEA RS07170
gene id: 398579:SPEA_RS07170
uniprot id: A8H2A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

398579:SPEA RS21305
gene id: 398579:SPEA_RS21305
uniprot id: A8H9Y4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS09415
gene id: 398579:SPEA_RS09415
uniprot id: A8H3I0
names: Similarity
messages: Belongs to the glutamate synthase family.

398579:SPEA RS19260
gene id: 398579:SPEA_RS19260
uniprot id: A8H8T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

398579:SPEA RS19000
gene id: 398579:SPEA_RS19000
uniprot id: A8H8N6
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS08065
gene id: 398579:SPEA_RS08065
uniprot id: A8H2R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

398579:SPEA RS19845
gene id: 398579:SPEA_RS19845
uniprot id: A8H953
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS13480
gene id: 398579:SPEA_RS13480
uniprot id: A8H5N3
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

398579:SPEA RS11785
gene id: 398579:SPEA_RS11785
uniprot id: A8H4T0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Transforms N(2)-succinylglutamate into succinate and glutamate.

398579:SPEA RS13645
gene id: 398579:SPEA_RS13645
uniprot id: A8H5Q4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

398579:SPEA RS13160
gene id: 398579:SPEA_RS13160
uniprot id: A8H5H1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion.
messages: Homodimer.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

398579:SPEA RS00070
gene id: 398579:SPEA_RS00070
uniprot id: A8GYF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cytoplasm
messages: Sulfur carrier protein which probably makes part of a sulfur-relay system.

398579:SPEA RS04735
gene id: 398579:SPEA_RS04735
uniprot id: A8H0Z4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS08570
gene id: 398579:SPEA_RS08570
uniprot id: A8H317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

398579:SPEA RS05390
gene id: 398579:SPEA_RS05390
uniprot id: A8H1C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RseB family.
messages: Periplasm

398579:SPEA RS08775
gene id: 398579:SPEA_RS08775
uniprot id: A8H355
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

398579:SPEA RS05015
gene id: 398579:SPEA_RS05015
uniprot id: A8H149
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

398579:SPEA RS21860
gene id: 398579:SPEA_RS21860
uniprot id: A8HA91
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

398579:SPEA RS00935
gene id: 398579:SPEA_RS00935
uniprot id: A8GYW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

398579:SPEA RS10715
gene id: 398579:SPEA_RS10715
uniprot id: A8H477
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

398579:SPEA RS02225
gene id: 398579:SPEA_RS02225
uniprot id: A8GZK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

398579:SPEA RS12750
gene id: 398579:SPEA_RS12750
uniprot id: A8H589
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

398579:SPEA RS18580
gene id: 398579:SPEA_RS18580
uniprot id: A8H8F9
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

398579:SPEA RS17975
gene id: 398579:SPEA_RS17975
uniprot id: A8H840
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

398579:SPEA RS01005
gene id: 398579:SPEA_RS01005
uniprot id: A8GYX6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

398579:SPEA RS03665
gene id: 398579:SPEA_RS03665
uniprot id: A8H0D4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

398579:SPEA RS11500
gene id: 398579:SPEA_RS11500
uniprot id: A8H4M5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS17900
gene id: 398579:SPEA_RS17900
uniprot id: A8H825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS02730
gene id: 398579:SPEA_RS02730
uniprot id: A8GZV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

398579:SPEA RS21120
gene id: 398579:SPEA_RS21120
uniprot id: A8H9U7
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS15130
gene id: 398579:SPEA_RS15130
uniprot id: A8H6J5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS15710
gene id: 398579:SPEA_RS15710
uniprot id: A8H6V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS01085
gene id: 398579:SPEA_RS01085
uniprot id: A8GYZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

398579:SPEA RS07405
gene id: 398579:SPEA_RS07405
uniprot id: A8H2F6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

398579:SPEA RS12850
gene id: 398579:SPEA_RS12850
uniprot id: A8H5A9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.
messages: Periplasm

398579:SPEA RS07795
gene id: 398579:SPEA_RS07795
uniprot id: A8H2K8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

398579:SPEA RS22265
gene id: 398579:SPEA_RS22265
uniprot id: A8HAG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

398579:SPEA RS13155
gene id: 398579:SPEA_RS13155
uniprot id: A8H5H0
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

398579:SPEA RS01975
gene id: 398579:SPEA_RS01975
uniprot id: A8GZF6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

398579:SPEA RS08595
gene id: 398579:SPEA_RS08595
uniprot id: A8H322
names: Similarity
messages: Belongs to the peptidase S33 family.

398579:SPEA RS07315
gene id: 398579:SPEA_RS07315
uniprot id: A8H2D8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

398579:SPEA RS20065
gene id: 398579:SPEA_RS20065
uniprot id: A8H991
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

398579:SPEA RS03130
gene id: 398579:SPEA_RS03130
uniprot id: A8H029
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm

398579:SPEA RS02305
gene id: 398579:SPEA_RS02305
uniprot id: A8GZM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

398579:SPEA RS07765
gene id: 398579:SPEA_RS07765
uniprot id: A8H2K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell inner membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).

398579:SPEA RS04660
gene id: 398579:SPEA_RS04660
uniprot id: A8H0X9
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

398579:SPEA RS04500
gene id: 398579:SPEA_RS04500
uniprot id: A8H0U9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

398579:SPEA RS18050
gene id: 398579:SPEA_RS18050
uniprot id: A8H855
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS07895
gene id: 398579:SPEA_RS07895
uniprot id: A8H2M8
names: Similarity
messages: Belongs to the HesB/IscA family.

398579:SPEA RS08395
gene id: 398579:SPEA_RS08395
uniprot id: A8H2Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

398579:SPEA RS14035
gene id: 398579:SPEA_RS14035
uniprot id: A8H5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

398579:SPEA RS01040
gene id: 398579:SPEA_RS01040
uniprot id: A8GYY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

398579:SPEA RS07495
gene id: 398579:SPEA_RS07495
uniprot id: A8H2H4
names: Cofactor
names: Similarity
messages: Belongs to the PHP family.
messages: Binds 3 Zn(2+) ions per subunit.

398579:SPEA RS19430
gene id: 398579:SPEA_RS19430
uniprot id: A8H8W9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS19905
gene id: 398579:SPEA_RS19905
uniprot id: A8H965
names: Similarity
messages: Belongs to the arginase family.

398579:SPEA RS15675
gene id: 398579:SPEA_RS15675
uniprot id: A8H6V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

398579:SPEA RS18625
gene id: 398579:SPEA_RS18625
uniprot id: A8H8G8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

398579:SPEA RS08125
gene id: 398579:SPEA_RS08125
uniprot id: A8H2S6
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

398579:SPEA RS00320
gene id: 398579:SPEA_RS00320
uniprot id: A8GYJ7
names: Similarity
messages: Belongs to the MotB family.

398579:SPEA RS05660
gene id: 398579:SPEA_RS05660
uniprot id: A8H1H6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

398579:SPEA RS14025
gene id: 398579:SPEA_RS14025
uniprot id: A8H5Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

398579:SPEA RS01480
gene id: 398579:SPEA_RS01480
uniprot id: A8GZ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

398579:SPEA RS07910
gene id: 398579:SPEA_RS07910
uniprot id: A8H2N1
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

398579:SPEA RS10855
gene id: 398579:SPEA_RS10855
uniprot id: A8H4A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

398579:SPEA RS14850
gene id: 398579:SPEA_RS14850
uniprot id: A8H6D9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS20905
gene id: 398579:SPEA_RS20905
uniprot id: A8H9Q6
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

398579:SPEA RS08680
gene id: 398579:SPEA_RS08680
uniprot id: A8H339
names: Similarity
messages: Belongs to the peptidase S49 family.

398579:SPEA RS18445
gene id: 398579:SPEA_RS18445
uniprot id: A8H8D2
names: Similarity
messages: Belongs to the UPF0270 family.

398579:SPEA RS05375
gene id: 398579:SPEA_RS05375
uniprot id: A8H1C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

398579:SPEA RS06040
gene id: 398579:SPEA_RS06040
uniprot id: A8H1P6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

398579:SPEA RS17550
gene id: 398579:SPEA_RS17550
uniprot id: A8H7V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

398579:SPEA RS00510
gene id: 398579:SPEA_RS00510
uniprot id: A8GYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

398579:SPEA RS17210
gene id: 398579:SPEA_RS17210
uniprot id: A8H7N8
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS14040
gene id: 398579:SPEA_RS14040
uniprot id: A8H5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

398579:SPEA RS04665
gene id: 398579:SPEA_RS04665
uniprot id: A8H0Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

398579:SPEA RS14625
gene id: 398579:SPEA_RS14625
uniprot id: A8H696
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

398579:SPEA RS08295
gene id: 398579:SPEA_RS08295
uniprot id: A8H2W0
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS04680
gene id: 398579:SPEA_RS04680
uniprot id: A8H0Y3
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS19710
gene id: 398579:SPEA_RS19710
uniprot id: A8H926
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

398579:SPEA RS05620
gene id: 398579:SPEA_RS05620
uniprot id: A8H1G8
names: Similarity
messages: Belongs to the UPF0246 family.

398579:SPEA RS06140
gene id: 398579:SPEA_RS06140
uniprot id: A8H1R5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS02095
gene id: 398579:SPEA_RS02095
uniprot id: A8GZI1
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

398579:SPEA RS03720
gene id: 398579:SPEA_RS03720
uniprot id: A8H0E5
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

398579:SPEA RS14185
gene id: 398579:SPEA_RS14185
uniprot id: A8H612
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

398579:SPEA RS06440
gene id: 398579:SPEA_RS06440
uniprot id: A8H1W5
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

398579:SPEA RS02285
gene id: 398579:SPEA_RS02285
uniprot id: A8GZL6
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

398579:SPEA RS05405
gene id: 398579:SPEA_RS05405
uniprot id: A8H1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

398579:SPEA RS19770
gene id: 398579:SPEA_RS19770
uniprot id: A8H938
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

398579:SPEA RS07065
gene id: 398579:SPEA_RS07065
uniprot id: A8H289
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

398579:SPEA RS18965
gene id: 398579:SPEA_RS18965
uniprot id: A8H8M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

398579:SPEA RS04705
gene id: 398579:SPEA_RS04705
uniprot id: A8H0Y8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

398579:SPEA RS19425
gene id: 398579:SPEA_RS19425
uniprot id: A8H8W8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS17695
gene id: 398579:SPEA_RS17695
uniprot id: A8H7Y5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

398579:SPEA RS09120
gene id: 398579:SPEA_RS09120
uniprot id: A8H3C1
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

398579:SPEA RS22100
gene id: 398579:SPEA_RS22100
uniprot id: A8HAD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

398579:SPEA RS16220
gene id: 398579:SPEA_RS16220
uniprot id: A8H758
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

398579:SPEA RS01405
gene id: 398579:SPEA_RS01405
uniprot id: A8GZ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

398579:SPEA RS03880
gene id: 398579:SPEA_RS03880
uniprot id: A8H0H5
names: Similarity
messages: Belongs to the aspartokinase family.

398579:SPEA RS20915
gene id: 398579:SPEA_RS20915
uniprot id: A8H9Q8
names: Similarity
messages: Belongs to the UPF0319 family.

398579:SPEA RS20515
gene id: 398579:SPEA_RS20515
uniprot id: A8H9H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

398579:SPEA RS21260
gene id: 398579:SPEA_RS21260
uniprot id: A8H9X5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

398579:SPEA RS16735
gene id: 398579:SPEA_RS16735
uniprot id: A8H7E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

398579:SPEA RS07160
gene id: 398579:SPEA_RS07160
uniprot id: A8H2A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

398579:SPEA RS10850
gene id: 398579:SPEA_RS10850
uniprot id: A8H4A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

398579:SPEA RS12290
gene id: 398579:SPEA_RS12290
uniprot id: A8H515
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

398579:SPEA RS07020
gene id: 398579:SPEA_RS07020
uniprot id: A8H280
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

398579:SPEA RS00580
gene id: 398579:SPEA_RS00580
uniprot id: A8GYP9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

398579:SPEA RS07285
gene id: 398579:SPEA_RS07285
uniprot id: A8H2D2
names: Subcellular Location Annotation
messages: Membrane

398579:SPEA RS07265
gene id: 398579:SPEA_RS07265
uniprot id: A8H2C8
names: Similarity
messages: Belongs to the type III secretion exporter family.

398579:SPEA RS07885
gene id: 398579:SPEA_RS07885
uniprot id: A8H2M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

398579:SPEA RS14900
gene id: 398579:SPEA_RS14900
uniprot id: A8H6E9
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

398579:SPEA RS04950
gene id: 398579:SPEA_RS04950
uniprot id: A8H137
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

398579:SPEA RS09995
gene id: 398579:SPEA_RS09995
uniprot id: A8H3U3
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

398579:SPEA RS12540
gene id: 398579:SPEA_RS12540
uniprot id: A8H552
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.

398579:SPEA RS08110
gene id: 398579:SPEA_RS08110
uniprot id: A8H2S3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

398579:SPEA RS11080
gene id: 398579:SPEA_RS11080
uniprot id: A8H4E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm

398579:SPEA RS19925
gene id: 398579:SPEA_RS19925
uniprot id: A8H969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

398579:SPEA RS02335
gene id: 398579:SPEA_RS02335
uniprot id: A8GZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family.
messages: Periplasm

398579:SPEA RS00825
gene id: 398579:SPEA_RS00825
uniprot id: A8GYU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

398579:SPEA RS01135
gene id: 398579:SPEA_RS01135
uniprot id: A8GZ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell inner membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

398579:SPEA RS02860
gene id: 398579:SPEA_RS02860
uniprot id: A8GZX4
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

398579:SPEA RS00950
gene id: 398579:SPEA_RS00950
uniprot id: A8GYW5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

398579:SPEA RS15730
gene id: 398579:SPEA_RS15730
uniprot id: A8H6W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

398579:SPEA RS03970
gene id: 398579:SPEA_RS03970
uniprot id: A8H0J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

398579:SPEA RS16040
gene id: 398579:SPEA_RS16040
uniprot id: A8H724
names: Similarity
messages: Belongs to the Smp family.

398579:SPEA RS06855
gene id: 398579:SPEA_RS06855
uniprot id: A8H249
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

398579:SPEA RS18605
gene id: 398579:SPEA_RS18605
uniprot id: A8H8G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

398579:SPEA RS14530
gene id: 398579:SPEA_RS14530
uniprot id: A8H678
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

398579:SPEA RS03840
gene id: 398579:SPEA_RS03840
uniprot id: A8H0G7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

398579:SPEA RS21590
gene id: 398579:SPEA_RS21590
uniprot id: A8HA38
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

398579:SPEA RS17820
gene id: 398579:SPEA_RS17820
uniprot id: A8H808
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

398579:SPEA RS10130
gene id: 398579:SPEA_RS10130
uniprot id: A8H3X0
names: Similarity
messages: Belongs to the peptidase S41A family.

398579:SPEA RS06170
gene id: 398579:SPEA_RS06170
uniprot id: A8H1S1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

398579:SPEA RS15910
gene id: 398579:SPEA_RS15910
uniprot id: A8H6Z8
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.