36329:PF3D7 1361000
gene id: 36329:PF3D7_1361000
uniprot id: Q8ID96
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.

36329:PF3D7 0208000
gene id: 36329:PF3D7_0208000
uniprot id: O96167
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 0316700
gene id: 36329:PF3D7_0316700
uniprot id: O77388
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

36329:PF3D7 1135600
gene id: 36329:PF3D7_1135600
uniprot id: Q8II07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome

36329:PF3D7 1130100
gene id: 36329:PF3D7_1130100
uniprot id: Q8II62
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

36329:PF3D7 0608500
gene id: 36329:PF3D7_0608500
uniprot id: C6KST3
names: Similarity
messages: Belongs to the peptidase T1A family.

36329:PF3D7 0613700
gene id: 36329:PF3D7_0613700
uniprot id: C6KSX9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

36329:PF3D7 0307300
gene id: 36329:PF3D7_0307300
uniprot id: O97251
names: Similarity
messages: Belongs to the MAPRE family.

36329:PF3D7 0619500
gene id: 36329:PF3D7_0619500
uniprot id: C6KT35
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

36329:PF3D7 0516500
gene id: 36329:PF3D7_0516500
uniprot id: C0H4E1
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1445500
gene id: 36329:PF3D7_1445500
uniprot id: Q8IL18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

36329:PF3D7 1304000
gene id: 36329:PF3D7_1304000
uniprot id: C0H598
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm

36329:PF3D7 0409600
gene id: 36329:PF3D7_0409600
uniprot id: Q9U0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 1 family.
messages: Nucleus

36329:PF3D7 0104400
gene id: 36329:PF3D7_0104400
uniprot id: Q8I295
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspH family.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
messages: Interacts with Fd/ferredoxin.
messages: Was shown to bind 1 [3Fe-4S] cluster (PubMed:24188825). However, it initially contains a [4Fe-4S] cluster which easily degrades into a [3Fe-4S] form in the presence of oxygen (Probable).
messages: apicoplast

36329:PF3D7 0603300
gene id: 36329:PF3D7_0603300
uniprot id: Q08210
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Mitochondrion inner membrane
messages: Monomer.

36329:PF3D7 0527200
gene id: 36329:PF3D7_0527200
uniprot id: Q8I3J3
names: Similarity
messages: Belongs to the peptidase C19 family.

36329:PF3D7 0624000
gene id: 36329:PF3D7_0624000
uniprot id: C6KT76
names: Similarity
messages: Belongs to the hexokinase family.

36329:PF3D7 0627700
gene id: 36329:PF3D7_0627700
uniprot id: C6KTB3
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 0528700
gene id: 36329:PF3D7_0528700
uniprot id: Q8I3I0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

36329:PF3D7 0914700
gene id: 36329:PF3D7_0914700
uniprot id: Q8I305
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1408000
gene id: 36329:PF3D7_1408000
uniprot id: Q8I6V3
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Component of the hemozoin formation complex (HFC) composed of falcipain 2, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN (PubMed:23471987). The HFC complex is involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage (PubMed:23471987).
messages: During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:29943906). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).
messages: Expressed during the asexual blood stage including in trophozoites (at protein level).
messages: Inhibited by pepstatin A (PubMed:29943906). Inhibited by KNI derived compounds (KNI-10742, 10743, 10395, 10333, and 10343) (PubMed:29943906).
messages: Membrane
messages: Not N-glycosylated.
messages: Proteolytically cleaved into the soluble active mature form in the digestive vacuole by cysteine protease falcipains; the process begins at the early ring stage (PubMed:14709539, PubMed:18308731). Proteolysis requires an acidic environment (PubMed:14709539, PubMed:18308731). In absence of falcipains, autoprocessing may serve as an alternate activation system (PubMed:18308731).
messages: Slight decrease in proliferation and slight increase in doubling time during the asexual blood stage.
messages: Vacuole lumen
messages: Vacuole membrane

36329:PF3D7 0617800
gene id: 36329:PF3D7_0617800
uniprot id: C6KT18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

36329:PF3D7 0923500
gene id: 36329:PF3D7_0923500
uniprot id: Q8I2S1
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

36329:PF3D7 0933500
gene id: 36329:PF3D7_0933500
uniprot id: Q8I2I3
names: Similarity
messages: Belongs to the TUBGCP family.

36329:PF3D7 0630900
gene id: 36329:PF3D7_0630900
uniprot id: C6KTE4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

36329:PF3D7 0516400
gene id: 36329:PF3D7_0516400
uniprot id: Q8I3U4
names: Similarity
messages: Belongs to the phosducin family.

36329:PF3D7 1034900
gene id: 36329:PF3D7_1034900
uniprot id: Q8IJ60
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 1420400
gene id: 36329:PF3D7_1420400
uniprot id: Q8ILP6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

36329:PF3D7 0908000
gene id: 36329:PF3D7_0908000
uniprot id: C0H524
names: Similarity
messages: Belongs to the nuclease type I family.

36329:PF3D7 0413600
gene id: 36329:PF3D7_0413600
uniprot id: Q8I1V1
names: Similarity
messages: Belongs to the AAA ATPase family.

36329:PF3D7 0927300
gene id: 36329:PF3D7_0927300
uniprot id: Q8I2N6
names: Similarity
messages: Belongs to the class-I fumarase family.

36329:PF3D7 1323400
gene id: 36329:PF3D7_1323400
uniprot id: Q8IE82
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

36329:PF3D7 1442100
gene id: 36329:PF3D7_1442100
uniprot id: C6S3I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

36329:PF3D7 0209600
gene id: 36329:PF3D7_0209600
uniprot id: O96181
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1469000
gene id: 36329:PF3D7_1469000
uniprot id: Q8IKE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

36329:PF3D7 0714500
gene id: 36329:PF3D7_0714500
uniprot id: Q8IBV2
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1123900
gene id: 36329:PF3D7_1123900
uniprot id: Q8IIC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

36329:PF3D7 0806400
gene id: 36329:PF3D7_0806400
uniprot id: Q8IAQ4
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

36329:PF3D7 1364500
gene id: 36329:PF3D7_1364500
uniprot id: Q8ID62
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 1120100
gene id: 36329:PF3D7_1120100
uniprot id: Q8IIG6
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

36329:PF3D7 1327700
gene id: 36329:PF3D7_1327700
uniprot id: A0A5K1K8T6
names: Similarity
messages: Belongs to the RENT3 family.

36329:PF3D7 0820000
gene id: 36329:PF3D7_0820000
uniprot id: C0H4W3
names: Biotechnology
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
messages: Catalytic component of a chromatin remodeling complex.
messages: Component of a chromatin-remodeling complex.
messages: Nucleus
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0617000
gene id: 36329:PF3D7_0617000
uniprot id: C6KT11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

36329:PF3D7 1426900
gene id: 36329:PF3D7_1426900
uniprot id: Q8ILJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

36329:PF3D7 1357900
gene id: 36329:PF3D7_1357900
uniprot id: Q8IDC6
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

36329:PF3D7 1223800
gene id: 36329:PF3D7_1223800
uniprot id: Q8I5H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 0917100
gene id: 36329:PF3D7_0917100
uniprot id: Q8I2Y2
names: Similarity
messages: Belongs to the type-1 OGG1 family.

36329:PF3D7 0819500
gene id: 36329:PF3D7_0819500
uniprot id: C0H4W0
names: Similarity
messages: Belongs to the RMD1/sif2 family.

36329:PF3D7 0909300
gene id: 36329:PF3D7_0909300
uniprot id: Q8I359
names: Similarity
messages: Belongs to the PDCD5 family.

36329:PF3D7 0920000
gene id: 36329:PF3D7_0920000
uniprot id: C0H545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

36329:PF3D7 0615100
gene id: 36329:PF3D7_0615100
uniprot id: C6KSZ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

36329:PF3D7 1457200
gene id: 36329:PF3D7_1457200
uniprot id: Q7KQL8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:11013257, PubMed:20673832). By modifying the redox status of targeted proteins, induces changes in their structure and activity (PubMed:19360125, PubMed:20673832). Reduces oxidized glutathione (GSSG), thereby acting as a backup for the glutathione redox system (PubMed:11013257). Reduces nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO) (PubMed:11013257). Also reduces oxidative stress by detoxifying hydrogen peroxide, tert-butyl hydroperoxide and cumene hydroperoxide (PubMed:14962358). Activates ornithine aminotransferase OAT by reducing a disulfide bond in the substrate binding loop, thereby enhancing the affinity of OAT for its substrates (PubMed:20673832). May reduce S-adenosyl-L-homocysteine hydrolase SAHH (PubMed:19360125).
messages: The disulfide bond between Cys-30 and Cys-33 acts as a redox-active center and is reduced by thioredoxin reductase TRXR.

36329:PF3D7 0823300
gene id: 36329:PF3D7_0823300
uniprot id: Q8IB67
names: Similarity
messages: Belongs to the acetyltransferase family. GCN5 subfamily.

36329:PF3D7 1363400
gene id: 36329:PF3D7_1363400
uniprot id: A0A5K1K8W0
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 1323300
gene id: 36329:PF3D7_1323300
uniprot id: Q8IE83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 1416100
gene id: 36329:PF3D7_1416100
uniprot id: Q8ILT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Probable GTP-binding protein involved in generating and maintaining the structure of the tubular endoplasmic reticulum network.

36329:PF3D7 1206700
gene id: 36329:PF3D7_1206700
uniprot id: Q8I5X8
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

36329:PF3D7 1210400
gene id: 36329:PF3D7_1210400
uniprot id: Q8I5U5
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0906500
gene id: 36329:PF3D7_0906500
uniprot id: Q8I384
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the hydrolysis of L-arginine into urea and L-ornithine, which is a precursor for polyamine biosynthesis (PubMed:15843155, PubMed:19456858, PubMed:20527960, PubMed:21728378). May play a role in parasite intra-hepatic development during the host liver stage (By similarity).
messages: Expressed during the asexual blood stage; expression is high in rings and young trophozoites, and low in mature trophozoites and schizonts.
messages: Feedback inhibition by product L-ornithine, (PubMed:15843155). Inhibited by 2(S)-amino-6-boronohexanoic acid (ABH); however, with less efficiency than human ARG1 (PubMed:20527960, PubMed:21728378).
messages: Homotrimer; oligomerization is dependent on Mn(2+) binding.

36329:PF3D7 1243000
gene id: 36329:PF3D7_1243000
uniprot id: Q8I4Z9
names: Similarity
messages: Belongs to the syntaxin family.

36329:PF3D7 1243800
gene id: 36329:PF3D7_1243800
uniprot id: Q8I4Z2
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0217500
gene id: 36329:PF3D7_0217500
uniprot id: P62344
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by calcium (PubMed:29716996, PubMed:18768477, PubMed:23204525, PubMed:17123645, PubMed:32484216). Upon calcium binding to the EF-hand domains, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (Probable) (PubMed:23204525). This, in turn may facilitate the autophosphorylation of the activation loop at Thr-231, which leads to the kinase activation (PubMed:19307175). May be negatively regulated by PKA-mediated phosphorylation (PubMed:28680058). Inhibited by purfalcamine (PubMed:23204525, PubMed:29716996).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
messages: Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:18768477, PubMed:19307175, PubMed:28680058, PubMed:29716996). By phosphorylating various proteins, required for microneme secretion and thus merozoite egress from and invasion of host erythrocytes (PubMed:23204525, PubMed:28680058, PubMed:29716996). During gametogenesis, essential for the development of both male and female gametes (By similarity). Phosphorylates SERA5 p50 which enhances SERA5 p50 protease activity; however, SERA5 p50 protease activity has been shown in other studies to be controversial (PubMed:29716996). Probably by phosphorylating SERA5 p50, plays a role in merozoite egress from host erythrocytes (PubMed:29716996). Probably prior or during merozoite invasion of host erythrocytes, phosphorylates rhoptry protein RhopH3 which is required for RhopH3 localization to rhoptries and for its secretion (PubMed:33024030). Probably in late schizonts, phosphorylates myosin A tail domain-interacting protein MTIP and glideosome-associated protein 45 GAP45, both of which are components of the motor complex that generates the force required by the parasite to invade host cells (PubMed:18768477, PubMed:28680058, PubMed:22539638). In late schizonts, phosphorylates inner membrane complex protein IMC1g (PubMed:28680058). In late schizonts, phosphorylates PKA regulatory subunit PKAr in a calcium-dependent manner, which may contribute to the dissociation of regulatory PKAr and catalytic PKAc subunits and promote the activation of PKAc (PubMed:28680058). May phosphorylate raf kinase inhibitory protein RKIP which in turn may regulate CDPK1 catalytic activity (PubMed:17123645). May phosphorylate proteins of the host erythrocyte membranes (By similarity).
messages: Cell membrane
messages: Conditional knockdown at the ring stage produces the development of mature schizonts and the subsequent release of merozoites from the host erythrocytes; however, the invasion of new erythrocytes by these merozoites is severely reduced due to a severe defect in adhesion to the erythrocyte membrane (PubMed:28680058). In merozoites, release of host glycophorin A/GYPA ligand EBA-175 from micronemes is impaired but not AMA1 (PubMed:28680058). In late schizont, phosphorylation of several proteins including GAP45, IMC1g and PKAr is reduced (PubMed:28680058). Reduced PKA activity (PubMed:28680058). Rhoptry protein RhopH3 phosphorylation and secretion are reduced in merozoites (PubMed:33024030).
messages: Cytoplasm
messages: Expressed during parasite asexual blood stages, specifically at the ring and schizont stages, in free merozoites and to a lesser extent in trophozoites (at protein level).
messages: Host cell membrane
messages: Membrane
messages: Monomer (PubMed:26149123). Forms a high molecular weight (250 and 400 kDa) complex (PubMed:26149123). Forms a complex composed of CDPK1, PKA regulatory subunit PKAr and 14-3-3I; the complex is formed in merozoites in response to low extracellular level of K(+) and may play a role in microneme secretion (PubMed:32817103). Interacts (when phosphorylated) with 14-3-3I in a Ca(2+)-independent manner; the interaction does not regulate CDPK1 catalytic activity but is required for merozoite invasion of host erythrocytes (PubMed:32484216, PubMed:32817103). Interacts with PKA regulatory subunit PKAr; in a Ca(2+)-dependent manner (PubMed:28680058, PubMed:32817103). Interacts with SERA5 p50 in the late schizont stage (PubMed:29716996). Interacts with inner membrane complex protein IMC1g in late schizonts (PubMed:28680058). Interacts with rhoptry protein RhopH3 in merozoites (PubMed:33024030).
messages: Myristoylated (PubMed:15491359). Myristoylation, palmitoylation and the basic cluster motif are required for the localization to the parasitophorous vacuole membrane (PubMed:15491359).
messages: Palmitoylated (Probable) (PubMed:32003970). Palmitoylation increases in merozoites in response to low level of extracellular K(+) in the host blood (PubMed:32003970). Myristoylation, palmitoylation and the basic cluster motif are required for the localization to the parasitophorous vacuole membrane (PubMed:15491359).
messages: Parasitophorous vacuole membrane
messages: Phosphorylation at Ser-64 occurs at late schizont stage and regulates CDPK1 protein-protein interaction (PubMed:26149123). Phosphorylated at Ser-28, Ser-34 and Ser-64 in merozoites in response to low extracellular level of K(+) (PubMed:32817103). Phosphorylation at Thr-231 may regulate CDPK1 kinase activity (PubMed:26149123). Phosphorylation increases in response to an increase in intracellular Ca(2+) levels (PubMed:32484216). Autophosphorylated in vitro (PubMed:17123645, PubMed:22539638, PubMed:23204525, PubMed:26149123, PubMed:32484216). Autophosphorylation does not affect membrane localization in vitro (PubMed:15491359).
messages: The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive (PubMed:19307175). The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains (PubMed:19307175, PubMed:23204525).
messages: Unlike P.berghei CDPK1, appears to be involved in the asexual blood stage and in male gamete exflagellation prior host erythrocyte membrane rupture.
messages: flagellum

36329:PF3D7 0819000
gene id: 36329:PF3D7_0819000
uniprot id: Q8IB25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

36329:PF3D7 0413900
gene id: 36329:PF3D7_0413900
uniprot id: Q8I1U8
names: Similarity
messages: Belongs to the peptidase C19 family.

36329:PF3D7 0210400
gene id: 36329:PF3D7_0210400
uniprot id: C6S3B5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

36329:PF3D7 0505300
gene id: 36329:PF3D7_0505300
uniprot id: Q8I449
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1475000
gene id: 36329:PF3D7_1475000
uniprot id: Q8IK88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

36329:PF3D7 1015800
gene id: 36329:PF3D7_1015800
uniprot id: Q8IJN8
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

36329:PF3D7 0927900
gene id: 36329:PF3D7_0927900
uniprot id: Q8I2N0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Endoplasmic reticulum membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

36329:PF3D7 1145700
gene id: 36329:PF3D7_1145700
uniprot id: Q8IHR1
names: Similarity
messages: Belongs to the methyltransferase superfamily.

36329:PF3D7 1247800
gene id: 36329:PF3D7_1247800
uniprot id: Q8I0V1
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

36329:PF3D7 1108500
gene id: 36329:PF3D7_1108500
uniprot id: Q8IIR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

36329:PF3D7 1144200
gene id: 36329:PF3D7_1144200
uniprot id: Q8IHS4
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0319000
gene id: 36329:PF3D7_0319000
uniprot id: O77368
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0811100
gene id: 36329:PF3D7_0811100
uniprot id: Q8IAU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 1467900
gene id: 36329:PF3D7_1467900
uniprot id: Q8IKF8
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1110500
gene id: 36329:PF3D7_1110500
uniprot id: Q8IIQ6
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

36329:PF3D7 1209800
gene id: 36329:PF3D7_1209800
uniprot id: Q8I5V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

36329:PF3D7 1346200
gene id: 36329:PF3D7_1346200
uniprot id: A0A5K1K8D5
names: Similarity
messages: Belongs to the MOG1 family.

36329:PF3D7 1030000
gene id: 36329:PF3D7_1030000
uniprot id: Q8IJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Nucleus

36329:PF3D7 1358500
gene id: 36329:PF3D7_1358500
uniprot id: Q8IDC0
names: Similarity
messages: Belongs to the ZPR1 family.

36329:PF3D7 0405600
gene id: 36329:PF3D7_0405600
uniprot id: Q8I1X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

36329:PF3D7 1354500
gene id: 36329:PF3D7_1354500
uniprot id: Q8IDF6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Parasitic protozoa lack the de novo purine biosynthesis pathway and rely exclusively on the salvage pathway for their purine nucleotide requirements.
messages: Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

36329:PF3D7 0507500
gene id: 36329:PF3D7_0507500
uniprot id: Q8I0V0
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Binds 3 Ca(2+) ions per subunit.
messages: Blood stage parasites are not viable (PubMed:18083098, PubMed:29459732). Initial schizont development is normal but merozoite egress is abolished due to a failure to rupture the parasitophorous vacuole membrane (PubMed:29459732).
messages: Expressed during the parasite blood stage, specifically in schizonts (at protein level).
messages: Heterodimer between p54 form and propeptide p31; the interaction inhibits p54 catalytic activity.
messages: Parasitophorous vacuole lumen
messages: Secreted
messages: Serine protease which plays an essential role in merozoite invasion of and egress from host erythrocytes by processing and activating various merozoite surface and parasitophorous vacuole proteins (PubMed:18083098, PubMed:19214190, PubMed:21220481, PubMed:29459732). Mediates the proteolytic maturation of serine proteases SERA4, SERA5 and SERA6 just prior to merozoite egress (PubMed:18083098, PubMed:19214190, PubMed:29459732). Prior to merozoite egress, cleaves merozoite surface proteins MSP1, MSP6 and MSP7, which form the MSP1/6/7 complex, and thereby may prime the parasite cell surface for invasion of fresh erythrocytes (PubMed:19214190, PubMed:29459732). Prior to merozoite egress, cleaves MSRP2 converting it to MSRP2 p25 form, and RAP1 converting it to RAP1 p67 form (PubMed:21220481).
messages: The disulfide bond between Cys-521 and Cys-534 acts as a redox-sensitive disulfide switch. The oxidized form is required for catalytic activity.
messages: The propeptide (p31) is cleaved, probably by autocatalysis, during the transport to or in the Golgi apparatus, and remains non-covalently associated with the p54 form as an inhibitor. p54 is further cleaved into the p45 form (By similarity). This cleavage is likely occurring in the exoneme prior to egress and is mediated by PMX/plasmepsin X (PubMed:32109369).
messages: The relevance of the N-glycosylation is not clear. In an insect expression system, SUB1 glycosylation appears to affect its processing into the active mature form suggesting that SUB1 may not be N-glycosylated in parasites.
messages: p54 and probably p47 forms are inhibited by the non-covalent interaction with the cleaved propeptide (PubMed:19214190). Inhibited by subtilisin propeptide-like protein SUB1-ProM (PubMed:31942933). Inhibited by small molecule MRT12113 (PubMed:18083098).

36329:PF3D7 1129000
gene id: 36329:PF3D7_1129000
uniprot id: Q8II73
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

36329:PF3D7 1027800
gene id: 36329:PF3D7_1027800
uniprot id: Q8IJC6
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

36329:PF3D7 0729400
gene id: 36329:PF3D7_0729400
uniprot id: Q8IBG5
names: Similarity
messages: Belongs to the BRX1 family.

36329:PF3D7 0802000
gene id: 36329:PF3D7_0802000
uniprot id: Q8IAM0
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

36329:PF3D7 1315900
gene id: 36329:PF3D7_1315900
uniprot id: A0A5K1K8Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

36329:PF3D7 0603000
gene id: 36329:PF3D7_0603000
uniprot id: C6KSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

36329:PF3D7 0603200
gene id: 36329:PF3D7_0603200
uniprot id: C6KSN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 0715900
gene id: 36329:PF3D7_0715900
uniprot id: Q8IBU1
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1358100
gene id: 36329:PF3D7_1358100
uniprot id: A0A5K1K911
names: Similarity
messages: Belongs to the SAS10 family.

36329:PF3D7 0621200
gene id: 36329:PF3D7_0621200
uniprot id: C6KT50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by Pdx2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: Cytoplasm
messages: Homohexamer and homododecamer. In the presence of Pdx2, forms a dodecamer of heterodimers.

36329:PF3D7 0608700
gene id: 36329:PF3D7_0608700
uniprot id: C6KST5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

36329:PF3D7 0320700
gene id: 36329:PF3D7_0320700
uniprot id: Q9NFA0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Causes a severe growth defect in host erythrocytes (PubMed:30127496). Export of protein containing a PEXEL motif, including PIESP2, PTP3 and PTP2 is severely reduced at the ring and trophozoite stages (PubMed:30127496). Similarly, export of RESA is reduced at the schizont stage (PubMed:30127496).
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11/SPC21 and three accessory subunits SPC25, SPC3/SPC22, SPC1/SPC12 (PubMed:30127496). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). Within the complex, interacts with SEC11/SPC21 (PubMed:30127496). Component of a complex composed of SPC25 and PMV; the interaction is mediated via the transmembrane domains (PubMed:30127496). The complex interacts with the SEC61 channel-forming translocon complex and is involved in the recognition and import of PEXEL motif-containing proteins into the ER for subsequent export (PubMed:30127496).
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:30127496). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). Also, regulatory component of the CSP25-plasmepsin PMV complex which cleaves the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence of several proteins (PubMed:30127496).
messages: Endoplasmic reticulum membrane
messages: Expressed during the asexual blood stage; expression is low at the ring stage and then increases through the trophozoite and schizont stages (at protein level).

36329:PF3D7 1435400
gene id: 36329:PF3D7_1435400
uniprot id: Q8ILB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1456000
gene id: 36329:PF3D7_1456000
uniprot id: Q8IKR9
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0828200
gene id: 36329:PF3D7_0828200
uniprot id: Q8IBB3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 1225800
gene id: 36329:PF3D7_1225800
uniprot id: Q8I5F9
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

36329:PF3D7 0823900
gene id: 36329:PF3D7_0823900
uniprot id: Q8IB73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 1018200
gene id: 36329:PF3D7_1018200
uniprot id: C6S3C9
names: Similarity
messages: Belongs to the PPP phosphatase family.

36329:PF3D7 1344000
gene id: 36329:PF3D7_1344000
uniprot id: C0H5G8
names: Similarity
messages: Belongs to the GcvT family.

36329:PF3D7 0309200
gene id: 36329:PF3D7_0309200
uniprot id: O77328
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

36329:PF3D7 1245300
gene id: 36329:PF3D7_1245300
uniprot id: Q8I4X8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 1118600
gene id: 36329:PF3D7_1118600
uniprot id: Q8III2
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

36329:PF3D7 1014200
gene id: 36329:PF3D7_1014200
uniprot id: Q8IJQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAP2/GCS1 family.
messages: Cell membrane
messages: Membrane

36329:PF3D7 1403700
gene id: 36329:PF3D7_1403700
uniprot id: Q8IM57
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1338200
gene id: 36329:PF3D7_1338200
uniprot id: A0A5K1K8V8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

36329:PF3D7 1143200
gene id: 36329:PF3D7_1143200
uniprot id: Q8IHT4
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0722500
gene id: 36329:PF3D7_0722500
uniprot id: Q8IBM8
names: Similarity
messages: Belongs to the CWC15 family.

36329:PF3D7 1474300
gene id: 36329:PF3D7_1474300
uniprot id: Q8IK95
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0212800
gene id: 36329:PF3D7_0212800
uniprot id: O96209
names: Similarity
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.

36329:PF3D7 1333000
gene id: 36329:PF3D7_1333000
uniprot id: Q8IDZ8
names: Similarity
messages: Belongs to the GroES chaperonin family.

36329:PF3D7 0930500
gene id: 36329:PF3D7_0930500
uniprot id: Q8I2K9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

36329:PF3D7 0519400
gene id: 36329:PF3D7_0519400
uniprot id: Q8I3R6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

36329:PF3D7 1407800
gene id: 36329:PF3D7_1407800
uniprot id: Q8IM16
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).
messages: Expressed during the asexual blood stage; expression begins in trophozoites and continues in schizonts (at protein level).
messages: Inhibited by KNI derived compounds KNI-10333 and to a lesser extent KNI-10743.
messages: It is unclear if PMIV is glycosylated as other members of the same enzyme family, ie. PMI and PMII, are not.
messages: Membrane
messages: Proteolytically cleaved into the soluble active mature form by cysteine proteases in the digestive vacuole of trophozoites. Proteolysis requires an acidic environment. Autoprocessing or transprocessing by other plasmepsins such as PMII may serve as an alternate activation system.
messages: Quadruple knockout of PMI, PMII, PMIII and PMIV causes a decrease in proliferation, an impaired proliferation in an amino acid-limited medium, a reduced formation of haemozoin and an abnormal accumulation of endosomal vesicles inside the digestive vacuole.
messages: Vacuole lumen

36329:PF3D7 1120500
gene id: 36329:PF3D7_1120500
uniprot id: Q8IIG2
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

36329:PF3D7 0103100
gene id: 36329:PF3D7_0103100
uniprot id: Q8I2A9
names: Similarity
messages: Belongs to the VPS51 family.

36329:PF3D7 0306000
gene id: 36329:PF3D7_0306000
uniprot id: Q9NLB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRQ/QCR8 family.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 0907700
gene id: 36329:PF3D7_0907700
uniprot id: Q8I374
names: Similarity
messages: Belongs to the PA28 family.

36329:PF3D7 0309000
gene id: 36329:PF3D7_0309000
uniprot id: O77334
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Binds 2 Zn(2+) ions.
messages: Cytoplasm
messages: Dual specificity protein phosphatase which dephosphorylates both phosphotyrosine and phosphoserine residues.
messages: Expressed during the parasite blood stage, including in rings, trophozoites and schizonts (at protein level) (PubMed:14698441). Expressed in gametocytes (at protein level) (PubMed:14698441).
messages: Interacts with PES.
messages: Nucleus

36329:PF3D7 1137500
gene id: 36329:PF3D7_1137500
uniprot id: Q8IHZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

36329:PF3D7 1248100
gene id: 36329:PF3D7_1248100
uniprot id: Q8I4V3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

36329:PF3D7 1201500
gene id: 36329:PF3D7_1201500
uniprot id: Q8I630
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

36329:PF3D7 0610100
gene id: 36329:PF3D7_0610100
uniprot id: C6KSU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

36329:PF3D7 1323900
gene id: 36329:PF3D7_1323900
uniprot id: A0A5K1K8R6
names: Similarity
messages: Belongs to the BCP1 family.

36329:PF3D7 1222000
gene id: 36329:PF3D7_1222000
uniprot id: Q8I5J3
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

36329:PF3D7 1146700
gene id: 36329:PF3D7_1146700
uniprot id: Q8IHQ1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

36329:PF3D7 0727000
gene id: 36329:PF3D7_0727000
uniprot id: Q8IBI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

36329:PF3D7 0829300
gene id: 36329:PF3D7_0829300
uniprot id: C0H4Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

36329:PF3D7 0817000
gene id: 36329:PF3D7_0817000
uniprot id: C0H4V1
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

36329:PF3D7 0708900
gene id: 36329:PF3D7_0708900
uniprot id: Q8IC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

36329:PF3D7 1451400
gene id: 36329:PF3D7_1451400
uniprot id: Q8IKW2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class IV subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2A to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance.

36329:PF3D7 0718400
gene id: 36329:PF3D7_0718400
uniprot id: Q8IBR7
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

36329:PF3D7 1429700
gene id: 36329:PF3D7_1429700
uniprot id: Q8ILG7
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

36329:PF3D7 1209000
gene id: 36329:PF3D7_1209000
uniprot id: Q8I5V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pym family.
messages: Cytoplasm

36329:PF3D7 1008000
gene id: 36329:PF3D7_1008000
uniprot id: Q8IJW3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

36329:PF3D7 1326100
gene id: 36329:PF3D7_1326100
uniprot id: A0A5K1K8S8
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1243200
gene id: 36329:PF3D7_1243200
uniprot id: C6S3L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

36329:PF3D7 0711400
gene id: 36329:PF3D7_0711400
uniprot id: Q8IBX6
names: Similarity
messages: Belongs to the SAP18 family.

36329:PF3D7 1203300
gene id: 36329:PF3D7_1203300
uniprot id: Q8I612
names: Similarity
messages: Belongs to the TBCC family.

36329:PF3D7 1470400
gene id: 36329:PF3D7_1470400
uniprot id: Q8IKD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 1306600
gene id: 36329:PF3D7_1306600
uniprot id: Q8IEP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

36329:PF3D7 1427500
gene id: 36329:PF3D7_1427500
uniprot id: Q8ILI9
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1354400
gene id: 36329:PF3D7_1354400
uniprot id: Q8IDF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

36329:PF3D7 1032600
gene id: 36329:PF3D7_1032600
uniprot id: Q8IJ81
names: Similarity
messages: Belongs to the RMD1/sif2 family.

36329:PF3D7 1408200
gene id: 36329:PF3D7_1408200
uniprot id: Q8IM14
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0110600
gene id: 36329:PF3D7_0110600
uniprot id: Q8I239
names: Activity Regulation
names: Developmental Stage
names: Function
messages: Catalytic activity is increase by myristoylated ARF1 (PubMed:19171150). Phosphatidic acid has no effect on catalytic activity (PubMed:19171150).
messages: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes.
messages: Expressed during the asexual blood stage (at protein level) (PubMed:19171150). Expressed in gametocytes (at protein level) (PubMed:19171150).

36329:PF3D7 0419800
gene id: 36329:PF3D7_0419800
uniprot id: Q8I1P0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.

36329:PF3D7 0903900
gene id: 36329:PF3D7_0903900
uniprot id: Q8I3B0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

36329:PF3D7 0506100
gene id: 36329:PF3D7_0506100
uniprot id: Q8I441
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

36329:PF3D7 1013900
gene id: 36329:PF3D7_1013900
uniprot id: Q8IJQ6
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

36329:PF3D7 0922200
gene id: 36329:PF3D7_0922200
uniprot id: Q7K6A4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

36329:PF3D7 1228800
gene id: 36329:PF3D7_1228800
uniprot id: Q8I5D0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1353500
gene id: 36329:PF3D7_1353500
uniprot id: Q8IDG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB4 family.
messages: Nucleus

36329:PF3D7 1323100
gene id: 36329:PF3D7_1323100
uniprot id: Q8IE85
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

36329:PF3D7 0621000
gene id: 36329:PF3D7_0621000
uniprot id: C6KT48
names: Similarity
messages: Belongs to the sigma-70 factor family.

36329:PF3D7 1357000
gene id: 36329:PF3D7_1357000
uniprot id: Q8I0P6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

36329:PF3D7 0314000
gene id: 36329:PF3D7_0314000
uniprot id: C0H473
names: Similarity
messages: Belongs to the p23/wos2 family.

36329:PF3D7 1223700
gene id: 36329:PF3D7_1223700
uniprot id: Q8I5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

36329:PF3D7 0829100
gene id: 36329:PF3D7_0829100
uniprot id: C0H4Y8
names: Similarity
messages: Belongs to the CCDC124 family.

36329:PF3D7 1115500
gene id: 36329:PF3D7_1115500
uniprot id: Q8IIK9
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1203600
gene id: 36329:PF3D7_1203600
uniprot id: Q8I609
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 0605600
gene id: 36329:PF3D7_0605600
uniprot id: C6KSQ4
names: Similarity
messages: Belongs to the NDK family.

36329:PF3D7 1116600
gene id: 36329:PF3D7_1116600
uniprot id: Q8IIK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

36329:PF3D7 1032500
gene id: 36329:PF3D7_1032500
uniprot id: Q8IJ82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

36329:PF3D7 0517800
gene id: 36329:PF3D7_0517800
uniprot id: C0H4E4
names: Biotechnology
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expressed during the parasite blood stage, including in rings, trophozoites, schizonts and free merozoites (at protein level).
messages: Human microRNA candidate miR-197 and to a lesser extent miR150 causes the down-regulation of apicortin and thus may be a possible candidate for nucleotide-based antimalarial treatment.
messages: Interacts with alpha-tubulin 1 and beta-tubulin; the interaction stabilizes microtubule assembly.
messages: Involved in the stabilization of microtubules (PubMed:33633135). Probably by controlling microtubules stabilization, plays a role in invasion, microneme secretion and parasite growth in host erythrocytes (PubMed:32493727).
messages: Tamoxifen used to treat breast cancer blocks the interaction between DCX/apicortin and, alpha-tubulin 1 and beta-tubulin resulting in microtubule destabilization.
messages: The doublecortin is involved in the binding to microtubules; however, it is not sufficient by itself and requires the partial p25alpha domain.
messages: The partial p25 alpha domain binds to microtubules.
messages: cytoskeleton

36329:PF3D7 0933600
gene id: 36329:PF3D7_0933600
uniprot id: Q8I2I2
names: Similarity
messages: Belongs to the peptidase M16 family.

36329:PF3D7 1023100
gene id: 36329:PF3D7_1023100
uniprot id: Q8IJH4
names: Similarity
messages: Belongs to the dynein heavy chain family.

36329:PF3D7 1234300
gene id: 36329:PF3D7_1234300
uniprot id: Q8I579
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus

36329:PF3D7 0714000
gene id: 36329:PF3D7_0714000
uniprot id: Q8IBV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

36329:PF3D7 1333800
gene id: 36329:PF3D7_1333800
uniprot id: A0A5K1K8U1
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1405200
gene id: 36329:PF3D7_1405200
uniprot id: Q8IM42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

36329:PF3D7 0802100
gene id: 36329:PF3D7_0802100
uniprot id: Q8IAM1
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1029600
gene id: 36329:PF3D7_1029600
uniprot id: Q8IJA9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine to produce inosine (PubMed:19728741, PubMed:31002765). Unlike mammalian adenosine deaminases, also catalyzes the deamination of 5'-methylthioadenosine (MTA), a by-product of polyamine biosynthesis, to produce 5'-methylthioinosine (MTI) (PubMed:19728741, PubMed:31002765). Plays an essential role in the purine salvage pathway which allows the parasite to use host cell purines for the synthesis of nucleic acids (Probable).
messages: Inhibited by coformycin and methylthiocoformycin (MT-coformycin).

36329:PF3D7 0103000
gene id: 36329:PF3D7_0103000
uniprot id: B9ZSH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

36329:PF3D7 1130400
gene id: 36329:PF3D7_1130400
uniprot id: Q8II60
names: Similarity
messages: Belongs to the AAA ATPase family.

36329:PF3D7 0520300
gene id: 36329:PF3D7_0520300
uniprot id: Q8I3Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

36329:PF3D7 1128600
gene id: 36329:PF3D7_1128600
uniprot id: Q8II77
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

36329:PF3D7 0802800
gene id: 36329:PF3D7_0802800
uniprot id: Q8IAM8
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

36329:PF3D7 0620500
gene id: 36329:PF3D7_0620500
uniprot id: C6KT45
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1250600
gene id: 36329:PF3D7_1250600
uniprot id: Q8I4S8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

36329:PF3D7 0524700
gene id: 36329:PF3D7_0524700
uniprot id: Q8I3L8
names: Similarity
messages: Belongs to the Tom22 family.

36329:PF3D7 0726800
gene id: 36329:PF3D7_0726800
uniprot id: C0H4P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

36329:PF3D7 1463400
gene id: 36329:PF3D7_1463400
uniprot id: Q8IKK2
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0520700
gene id: 36329:PF3D7_0520700
uniprot id: Q8I3Q4
names: Similarity
messages: Belongs to the CDC73 family.

36329:PF3D7 0808100
gene id: 36329:PF3D7_0808100
uniprot id: C0H4T0
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

36329:PF3D7 1311000
gene id: 36329:PF3D7_1311000
uniprot id: Q8IEK7
names: Similarity
messages: Belongs to the complex I LYR family.

36329:PF3D7 0932200
gene id: 36329:PF3D7_0932200
uniprot id: Q8I2J4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the profilin family.
messages: Binds actin.
messages: Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers (By similarity).
messages: The actin binding residues are poorly conserved between Plasmodium and other organisms. The Plasmodium-specific profilin mini-domain may have a role in binding to membrane phospholipids.
messages: cytoskeleton

36329:PF3D7 0213700
gene id: 36329:PF3D7_0213700
uniprot id: O96217
names: Similarity
messages: Belongs to the FAM136 family.

36329:PF3D7 1360500
gene id: 36329:PF3D7_1360500
uniprot id: Q8IDA0
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal guanylate activity of the recombinant guanylate cyclase domains 1 and 2 is not modulated by an increase in Ca(2+) levels or by the gametogenesis inducer xanthurenic acid.
messages: Binds 2 magnesium ions per subunit (By similarity). Is also active with manganese (in vitro) (Probable).
messages: Catalyzes the synthesis of the second messenger cGMP from GTP (PubMed:10747978, PubMed:11703675, PubMed:18452584). Regulates cGMP production in gametocytes; however, is dispensable for the initiation of gametogenesis (PubMed:18452584). Does not have adenylate cyclase activity (PubMed:10747978).
messages: During the blood stage, specifically expressed in gametocytes.
messages: In the C-terminal section; belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: In the N-terminal section; belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane
messages: The N-terminus contains a P-type ATPase-like domain which is required for guanylate cyclase activity.

36329:PF3D7 0622500
gene id: 36329:PF3D7_0622500
uniprot id: C6KT62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

36329:PF3D7 0932300
gene id: 36329:PF3D7_0932300
uniprot id: Q8I2J3
names: Similarity
messages: Belongs to the peptidase M18 family.

36329:PF3D7 1317900
gene id: 36329:PF3D7_1317900
uniprot id: Q8IED7
names: Similarity
messages: Belongs to the CBF/MAK21 family.

36329:PF3D7 1219900
gene id: 36329:PF3D7_1219900
uniprot id: Q8I5L3
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

36329:PF3D7 1402100
gene id: 36329:PF3D7_1402100
uniprot id: Q8IM68
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

36329:PF3D7 0627800
gene id: 36329:PF3D7_0627800
uniprot id: C6KTB4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

36329:PF3D7 1415400
gene id: 36329:PF3D7_1415400
uniprot id: Q8ILU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 1113300
gene id: 36329:PF3D7_1113300
uniprot id: Q8IIM9
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1428600
gene id: 36329:PF3D7_1428600
uniprot id: Q8ILH8
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

36329:PF3D7 1112200
gene id: 36329:PF3D7_1112200
uniprot id: Q8IIP1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

36329:PF3D7 1027100
gene id: 36329:PF3D7_1027100
uniprot id: Q8IJD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: nucleolus

36329:PF3D7 1415000
gene id: 36329:PF3D7_1415000
uniprot id: Q8ILU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

36329:PF3D7 0818400
gene id: 36329:PF3D7_0818400
uniprot id: C0H4V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

36329:PF3D7 0306900
gene id: 36329:PF3D7_0306900
uniprot id: O97248
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

36329:PF3D7 0314100.1
gene id: 36329:PF3D7_0314100.1
uniprot id: A0A143ZX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

36329:PF3D7 0902800
gene id: 36329:PF3D7_0902800
uniprot id: Q8I3C0
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 0518300
gene id: 36329:PF3D7_0518300
uniprot id: A0A5K1K7U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 1431000
gene id: 36329:PF3D7_1431000
uniprot id: Q8ILF5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

36329:PF3D7 1369700
gene id: 36329:PF3D7_1369700
uniprot id: C0H5L8
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

36329:PF3D7 0105300
gene id: 36329:PF3D7_0105300
uniprot id: Q8I288
names: Similarity
messages: Belongs to the CAP family.

36329:PF3D7 0919600
gene id: 36329:PF3D7_0919600
uniprot id: Q8I2V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

36329:PF3D7 1113900
gene id: 36329:PF3D7_1113900
uniprot id: Q7KQK7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

36329:PF3D7 1409200.1
gene id: 36329:PF3D7_1409200.1
uniprot id: Q8IM04
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1303500
gene id: 36329:PF3D7_1303500
uniprot id: Q8IET0
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

36329:PF3D7 1143900
gene id: 36329:PF3D7_1143900
uniprot id: Q8IHS6
names: Function
names: Similarity
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

36329:PF3D7 1022700
gene id: 36329:PF3D7_1022700
uniprot id: Q8IJH8
names: Similarity
messages: Belongs to the phospholipid scramblase family.

36329:PF3D7 1007000
gene id: 36329:PF3D7_1007000
uniprot id: Q8IJX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0916000
gene id: 36329:PF3D7_0916000
uniprot id: Q8I2Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

36329:PF3D7 1015900
gene id: 36329:PF3D7_1015900
uniprot id: Q8IJN7
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Binds 2 Mg(2+) ions per subunit (PubMed:25787157). Mg(2+) is required for catalysis and for stabilizing the dimer (PubMed:25787157). Unlike for mammalian and yeast enolases, Mg(2+) is dispensable to form an active closed conformation (PubMed:25787157). Inhibited by high levels of Mg(2+) (By similarity).
messages: Cell membrane
messages: Cell surface
messages: Cytoplasm
messages: During the asexual blood stage, expressed in rings, trophozoites, schizonts and merozoites (at protein level).
messages: Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:19268421, PubMed:25787157). In addition to glycolysis, involved in various processes such as parasite development and invasion (By similarity). Plays an essential role during ookinete invasion of the mosquito vector midgut by mediating the interaction of the ookinete with the midgut epithelium and, further, by binding to mammalian host plasminogen in the blood meal, whose conversion to active plasmin promotes the invasion process (By similarity).
messages: Homodimer (PubMed:19268421, PubMed:25787157). Forms a complex at least composed of DegP, ENO and HSP70 (PubMed:24494818). Interacts with G-actin (PubMed:19642995). Interacts (via the DKSLVK motif) with mammalian host PLG/plasminogen (present in the mosquito blood meal); the interaction occurs at the ookinete cell surface and is required for ookinete invasion of the mosquito midgut (PubMed:19642995). Interacts with A.gambiae EBP; depending on the Plasmodium species, the interaction is either involved in ookinete invasion of the mosquito midgut (P.berghei) or is dispensable (P.falciparum) (By similarity).
messages: Nucleus
messages: The DKSLVK motif binds to the lysine-binding Kringle domains of plasminogen from various mammalian species (By similarity). This motif is present only in enolases of plant and several microbial pathogens including Plasmodium species (By similarity).
messages: The pentapeptide insert motif is required for the stabilization of the apo-enzyme in an active closed conformation, independently of Mg(2+) binding (PubMed:19268421, PubMed:25787157). The motif is also required for homodimerization (PubMed:19268421, PubMed:25787157). This motif is only present in Apicomplexa and plant enolases (Probable).
messages: Vacuole
messages: cytoskeleton

36329:PF3D7 0911000
gene id: 36329:PF3D7_0911000
uniprot id: C0H532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

36329:PF3D7 1232000
gene id: 36329:PF3D7_1232000
uniprot id: Q8I5A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

36329:PF3D7 0406100
gene id: 36329:PF3D7_0406100
uniprot id: Q6ZMA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.

36329:PF3D7 0708500
gene id: 36329:PF3D7_0708500
uniprot id: Q8IC04
names: Similarity
messages: Belongs to the NKAP family.

36329:PF3D7 0614500
gene id: 36329:PF3D7_0614500
uniprot id: C6KSY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

36329:PF3D7 0811200
gene id: 36329:PF3D7_0811200
uniprot id: Q8IAU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0316100
gene id: 36329:PF3D7_0316100
uniprot id: Q9NDU6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

36329:PF3D7 1034000
gene id: 36329:PF3D7_1034000
uniprot id: Q8IJ69
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

36329:PF3D7 0212300
gene id: 36329:PF3D7_0212300
uniprot id: O96203
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Heterodimer of two subunits, one of which binds GTP.

36329:PF3D7 0821800
gene id: 36329:PF3D7_0821800
uniprot id: C0H4W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

36329:PF3D7 1468200
gene id: 36329:PF3D7_1468200
uniprot id: Q8IKF5
names: Similarity
messages: Belongs to the TLS1 family.

36329:PF3D7 1216300
gene id: 36329:PF3D7_1216300
uniprot id: Q8I5P4
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 1427600
gene id: 36329:PF3D7_1427600
uniprot id: Q8ILI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

36329:PF3D7 1021600
gene id: 36329:PF3D7_1021600
uniprot id: Q8IJI7
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

36329:PF3D7 1441400
gene id: 36329:PF3D7_1441400
uniprot id: Q8IL56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

36329:PF3D7 1323500
gene id: 36329:PF3D7_1323500
uniprot id: Q8I6Z5
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Component of a complex composed of SPC25 and PMV; the interaction is mediated via the transmembrane domains (PubMed:30127496). The complex interacts with the SEC61 channel-forming translocon complex and is involved in the recognition and import of PEXEL motif-containing proteins into the ER for subsequent export (PubMed:30127496).
messages: During the asexual blood stage, plays an essential role in the export of several proteins into the host erythrocytes by cleaving the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence (PubMed:20130643, PubMed:20130644, PubMed:24983235, PubMed:30127496, PubMed:30517136). Specifically, cleaves after the leucine residue in the RxLxE/Q/D (or RxLxxE) motif of exported proteins including RESA, EMP2, EMP3, KAHRP, RIF/Rifin and STEVOR (PubMed:20130643, PubMed:20130644, PubMed:23387285, PubMed:25447707, PubMed:25986559, PubMed:24983235). Also, by regulating protein export, plays an essential role in gametocyte development and thus, parasite transmission to the mosquito vector (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed during the asexual blood stage; expression is low at the ring stage and then increases through the trophozoite and schizont stages (at protein level).
messages: Inhibited by peptidomimetic inhibitor WEHI-842 (PubMed:26214367). Inhibited by Cu(2+) and Hg(2+) (PubMed:25447707).
messages: It is not clear if the zymogen has a cleavable propeptide (PubMed:25447707). In vitro, appears to be cleaved between Asn-80 and Ala-81 (PubMed:25447707). Cleavage of the putative propeptide is dispensable for catalytic activity (PubMed:25447707, PubMed:25986559).
messages: It is unclear if PMV is glycosylated as other members of the same enzyme family, ie. PMI and PMII, are not.
messages: The transmembrane domain is essential for localization to the endoplasmic reticulum.

36329:PF3D7 1124900
gene id: 36329:PF3D7_1124900
uniprot id: Q8IIB4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

36329:PF3D7 1432900
gene id: 36329:PF3D7_1432900
uniprot id: Q8ILD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF-assemblin family.
messages: cytoskeleton

36329:PF3D7 0607700
gene id: 36329:PF3D7_0607700
uniprot id: C6KSS5
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1409500
gene id: 36329:PF3D7_1409500
uniprot id: Q8IM00
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1349800
gene id: 36329:PF3D7_1349800
uniprot id: Q8IDK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

36329:PF3D7 0317000
gene id: 36329:PF3D7_0317000
uniprot id: O77396
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 0522800
gene id: 36329:PF3D7_0522800
uniprot id: Q8I3N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

36329:PF3D7 0618700
gene id: 36329:PF3D7_0618700
uniprot id: C6KT27
names: Similarity
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.

36329:PF3D7 0912800
gene id: 36329:PF3D7_0912800
uniprot id: Q8I324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

36329:PF3D7 1309600
gene id: 36329:PF3D7_1309600
uniprot id: Q8IEL9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

36329:PF3D7 0904400
gene id: 36329:PF3D7_0904400
uniprot id: Q8I3A5
names: Similarity
messages: Belongs to the SPCS3 family.

36329:PF3D7 0730100
gene id: 36329:PF3D7_0730100
uniprot id: Q8IBF9
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

36329:PF3D7 1357800
gene id: 36329:PF3D7_1357800
uniprot id: C0H5I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

36329:PF3D7 1457000
gene id: 36329:PF3D7_1457000
uniprot id: Q8IKQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

36329:PF3D7 1404000
gene id: 36329:PF3D7_1404000
uniprot id: Q8IM54
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1322500
gene id: 36329:PF3D7_1322500
uniprot id: Q8IE90
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

36329:PF3D7 1431500
gene id: 36329:PF3D7_1431500
uniprot id: Q8ILF0
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

36329:PF3D7 1010800
gene id: 36329:PF3D7_1010800
uniprot id: Q8IJT7
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

36329:PF3D7 1103100
gene id: 36329:PF3D7_1103100
uniprot id: Q8IIX0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

36329:PF3D7 1454100
gene id: 36329:PF3D7_1454100
uniprot id: Q8I718
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.

36329:PF3D7 1003500
gene id: 36329:PF3D7_1003500
uniprot id: Q8IK02
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

36329:PF3D7 1214300
gene id: 36329:PF3D7_1214300
uniprot id: C6S3K4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

36329:PF3D7 0626700
gene id: 36329:PF3D7_0626700
uniprot id: C6KTA3
names: Similarity
messages: Belongs to the MYG1 family.

36329:PF3D7 0829200
gene id: 36329:PF3D7_0829200
uniprot id: Q8IBC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

36329:PF3D7 0303700
gene id: 36329:PF3D7_0303700
uniprot id: O97227
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

36329:PF3D7 1309700
gene id: 36329:PF3D7_1309700
uniprot id: Q8IEL8
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0215900
gene id: 36329:PF3D7_0215900
uniprot id: O96238
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

36329:PF3D7 0728000
gene id: 36329:PF3D7_0728000
uniprot id: Q8IBH7
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Expressed during the asexual blood stage, including rings, trophozoites, schizonts (at protein level) (PubMed:22355110, PubMed:29241041). Expressed in male and female gametocytes (at protein level) (PubMed:22355110).
messages: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity). May regulate protein translation in response to amino acid starvation (Probable). May regulate protein at various stages of parasite development (Probable).
messages: Phosphorylated at Ser-59 by eIK1 in response to amino acid starvation (PubMed:19435497). Phosphorylates at Ser-59 in schizonts and gametocytes but not in rings and young trophozoites (PubMed:22355110, PubMed:29241041). Phosphorylates at Ser-59 by eIK2 in salivary gland sporozoites but not in midgut and hemocoel sporozoites (By similarity). Dephosphorylated at Ser-59 by UIS2 (PubMed:26735921). Phosphorylation of eIF2alpha subunit of the pre-initiation complex eIF2 inhibits recycling of inactive eIF2-GDP to active eIF2-GTP by limiting the activity of the guanine nucleotide exchange factor eIF2B and thus, inhibits protein translation (PubMed:19435497).
messages: Stress granule

36329:PF3D7 0509100
gene id: 36329:PF3D7_0509100
uniprot id: Q8I413
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Nucleus

36329:PF3D7 0307200
gene id: 36329:PF3D7_0307200
uniprot id: O97250
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

36329:PF3D7 0508300
gene id: 36329:PF3D7_0508300
uniprot id: Q8I420
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1211300
gene id: 36329:PF3D7_1211300
uniprot id: Q8I5T7
names: Similarity
messages: Belongs to the MCM family.

36329:PF3D7 0627400
gene id: 36329:PF3D7_0627400
uniprot id: C6KTB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 0422400
gene id: 36329:PF3D7_0422400
uniprot id: Q8IFP2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

36329:PF3D7 0611000
gene id: 36329:PF3D7_0611000
uniprot id: C6KSV5
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1145100
gene id: 36329:PF3D7_1145100
uniprot id: Q8IHR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

36329:PF3D7 1355500
gene id: 36329:PF3D7_1355500
uniprot id: Q8IDE7
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

36329:PF3D7 1009000
gene id: 36329:PF3D7_1009000
uniprot id: Q8IJV5
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

36329:PF3D7 0528100
gene id: 36329:PF3D7_0528100
uniprot id: Q8I3I6
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

36329:PF3D7 0524800
gene id: 36329:PF3D7_0524800
uniprot id: Q8I3L7
names: Similarity
messages: Belongs to the UFD1 family.

36329:PF3D7 0318200
gene id: 36329:PF3D7_0318200
uniprot id: O77375
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

36329:PF3D7 1431900
gene id: 36329:PF3D7_1431900
uniprot id: Q8ILE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

36329:PF3D7 0207600
gene id: 36329:PF3D7_0207600
uniprot id: Q9TY95
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Conditional knockout at the merozoite stage, does not cause any defect in schizont morphology, merozoite number and maturation initially. During the subsequent invasive cycle in host erythrocytes, merozoite replication is severely impaired due to a premature rupture of the parasitophorous vacuole and erythrocyte membranes resulting in an inefficient dispersal of released merozoites.
messages: Expressed during parasite asexual blood stages, specifically in late trophozoite and schizont stages (at protein level).
messages: In contrast to other serine-repeat antigen proteins (SERA) of the peptidase C1 family, contains a serine residue at the position of the canonical catalytic cysteine and has been shown to lack protease activity. However, other studies show that it has protease activity towards synthetic peptides in vitro (PubMed:13679369, PubMed:24769454, PubMed:29716996).
messages: Interacts (via C-terminus) with human VTN (via hemopexin repeat 2); may form heterotetramers of two VTN and SERA5 P47 heterodimers; the interaction may protect merozoites from phagocytosis by host monocytes; VTN glycosylation appears to be dispensable for the interaction.
messages: Just prior to merozoite egress from host erythrocytes, proteolytically cleaved into multiple fragments (PubMed:18083098, PubMed:25599609, PubMed:24769454). Cleaved by SUB1 into p47 and p73, p73 is further cleaved by SUB1 into p56 and p18 and p56 is further processed into p50 by an unidentified protease (PubMed:25599609, PubMed:18083098). p47 remains covalently associated with p18 via disulfide bond (PubMed:25599609). p47 can be processed into p25n and p25c by SUB1 (PubMed:25599609, PubMed:18083098). p25c and p25n remain associated with p18 (PubMed:25599609). Proteolytic processing is essential for merozoite egress from host erythrocytes (PubMed:28683142). The cleavage of the propeptide to produce p50 is necessary for protease activity and to promote merozoite egress (PubMed:24769454).
messages: May interact (via C-terminus) with PTKL (via SAM domain).
messages: May prevent merozoite phagocytosis by host monocytes via interaction with host VTN at the merozoite surface (By similarity). Plays a role in parasite growth (By similarity).
messages: Monomer (PubMed:13679369, PubMed:25599609). Interacts with kinase CPK1/CDPK1 at the schizont stage (PubMed:29716996).
messages: Parasitophorous vacuole
messages: Phosphorylation by CPK1/CDPK1 increases SERA5 protease activity towards a synthetic peptide in vitro.
messages: Plays an essential role during the asexual blood stage development by controlling the kinetics of merozoite egress from host erythrocytes (PubMed:25599609, PubMed:28683142). Specifically, prevents premature rupture of the parasitophorous vacuole and host erythrocyte membranes (PubMed:28683142).
messages: Produced during parasite asexual blood stages, specifically at the merozoite stage just prior to egress (at protein level).
messages: Protease activity is controversial (PubMed:25599609). Has been shown in a number of studies to have protease activity towards a synthetic peptide in vitro (PubMed:13679369, PubMed:24769454, PubMed:29716996). Has also been shown to lack protease activity towards a synthetic peptide in vitro (PubMed:25599609).
messages: Secreted

36329:PF3D7 1474800
gene id: 36329:PF3D7_1474800
uniprot id: Q8IK90
names: Similarity
messages: Belongs to the peptidase T1A family.

36329:PF3D7 1453700
gene id: 36329:PF3D7_1453700
uniprot id: Q8IKU1
names: Similarity
messages: Belongs to the p23/wos2 family.

36329:PF3D7 0422700
gene id: 36329:PF3D7_0422700
uniprot id: Q8IFN9
names: Similarity
messages: Belongs to the DEAD box helicase family.

36329:PF3D7 0612800
gene id: 36329:PF3D7_0612800
uniprot id: C6KSX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell surface

36329:PF3D7 1412600
gene id: 36329:PF3D7_1412600
uniprot id: Q8ILW8
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

36329:PF3D7 1206500
gene id: 36329:PF3D7_1206500
uniprot id: Q8I5Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

36329:PF3D7 0827500
gene id: 36329:PF3D7_0827500
uniprot id: C0H4Y5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL21 family.

36329:PF3D7 1030100
gene id: 36329:PF3D7_1030100
uniprot id: Q8IJA4
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0623500
gene id: 36329:PF3D7_0623500
uniprot id: C6KT71
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Homodimer.

36329:PF3D7 1427900
gene id: 36329:PF3D7_1427900
uniprot id: Q8ILI6
names: Similarity
messages: Belongs to the ANP32 family.

36329:PF3D7 0606100
gene id: 36329:PF3D7_0606100
uniprot id: C6KSQ9
names: Similarity
messages: Belongs to the RRM NELF-E family.

36329:PF3D7 1005700
gene id: 36329:PF3D7_1005700
uniprot id: Q8IJY3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

36329:PF3D7 1404400
gene id: 36329:PF3D7_1404400
uniprot id: Q8IM50
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

36329:PF3D7 1341300
gene id: 36329:PF3D7_1341300
uniprot id: C0H5G3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

36329:PF3D7 0627900
gene id: 36329:PF3D7_0627900
uniprot id: C6KTB5
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

36329:PF3D7 0515800
gene id: 36329:PF3D7_0515800
uniprot id: Q8I3V0
names: Similarity
messages: Belongs to the BolA/IbaG family.

36329:PF3D7 0318800
gene id: 36329:PF3D7_0318800
uniprot id: O77370
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

36329:PF3D7 0934100
gene id: 36329:PF3D7_0934100
uniprot id: Q8I2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

36329:PF3D7 0319300
gene id: 36329:PF3D7_0319300
uniprot id: O77397
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 1407000
gene id: 36329:PF3D7_1407000
uniprot id: Q8IM24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0828400
gene id: 36329:PF3D7_0828400
uniprot id: Q8IBB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

36329:PF3D7 1368700
gene id: 36329:PF3D7_1368700
uniprot id: Q8ID23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 0411900
gene id: 36329:PF3D7_0411900
uniprot id: Q9U0H1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

36329:PF3D7 1451100
gene id: 36329:PF3D7_1451100
uniprot id: Q8IKW5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

36329:PF3D7 1415700
gene id: 36329:PF3D7_1415700
uniprot id: Q8ILT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm

36329:PF3D7 1114800
gene id: 36329:PF3D7_1114800
uniprot id: Q8IIL4
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

36329:PF3D7 1366600
gene id: 36329:PF3D7_1366600
uniprot id: Q8ID42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

36329:PF3D7 1435000
gene id: 36329:PF3D7_1435000
uniprot id: Q8ILB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

36329:PF3D7 1329000
gene id: 36329:PF3D7_1329000
uniprot id: Q8IE49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

36329:PF3D7 1353800
gene id: 36329:PF3D7_1353800
uniprot id: Q8IDG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

36329:PF3D7 0803200
gene id: 36329:PF3D7_0803200
uniprot id: Q8IAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF-assemblin family.
messages: cytoskeleton

36329:PF3D7 1471500
gene id: 36329:PF3D7_1471500
uniprot id: Q8IKC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

36329:PF3D7 0918900
gene id: 36329:PF3D7_0918900
uniprot id: Q8I2W4
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

36329:PF3D7 1305300
gene id: 36329:PF3D7_1305300
uniprot id: C0H5A0
names: Similarity
messages: Belongs to the GCN1 family.

36329:PF3D7 0704200
gene id: 36329:PF3D7_0704200
uniprot id: Q8IC28
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 1135900
gene id: 36329:PF3D7_1135900
uniprot id: Q8II05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0207500
gene id: 36329:PF3D7_0207500
uniprot id: Q9TY96
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cysteine protease which plays an essential role in merozoite egress from host erythrocytes. May cleave host SPTB/beta spectrin and ANK1/ankyrin-1 which disrupts host erythrocyte actin cytoskeleton and leads to host erythrocyte cell membrane rupture.
messages: Expressed during parasite asexual blood stages, specifically at the schizont stage (at protein level).
messages: Just prior to merozoite egress from host erythrocytes, proteolytically cleaved by SUB1 to generate the active 75kDa form.
messages: Parasitophorous vacuole lumen
messages: Parasitophorous vacuole membrane

36329:PF3D7 1331700
gene id: 36329:PF3D7_1331700
uniprot id: Q8IE10
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 1464000
gene id: 36329:PF3D7_1464000
uniprot id: Q8IKJ7
names: Similarity
messages: Belongs to the VPS72/YL1 family.

36329:PF3D7 1349200
gene id: 36329:PF3D7_1349200
uniprot id: Q8IDK7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 1342800
gene id: 36329:PF3D7_1342800
uniprot id: Q8IDR1
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

36329:PF3D7 0715100
gene id: 36329:PF3D7_0715100
uniprot id: Q8IBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

36329:PF3D7 1229500
gene id: 36329:PF3D7_1229500
uniprot id: Q8I5C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

36329:PF3D7 1243600
gene id: 36329:PF3D7_1243600
uniprot id: Q8I4Z4
names: Similarity
messages: Belongs to the SUI1 family.

36329:PF3D7 1014700
gene id: 36329:PF3D7_1014700
uniprot id: Q8IJP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

36329:PF3D7 1224300
gene id: 36329:PF3D7_1224300
uniprot id: Q8I5H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

36329:PF3D7 0207700
gene id: 36329:PF3D7_0207700
uniprot id: O96164
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 1311700
gene id: 36329:PF3D7_1311700
uniprot id: Q8I6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Mitochondrion intermembrane space

36329:PF3D7 0613500
gene id: 36329:PF3D7_0613500
uniprot id: C6KSX7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

36329:PF3D7 0420300
gene id: 36329:PF3D7_0420300
uniprot id: Q8I1N6
names: Biotechnology
names: Subcellular Location Annotation
messages: Nucleus
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1216200
gene id: 36329:PF3D7_1216200
uniprot id: Q8I5P5
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

36329:PF3D7 1223100
gene id: 36329:PF3D7_1223100
uniprot id: Q7KQK0
names: Similarity
messages: Belongs to the cAMP-dependent kinase regulatory chain family.

36329:PF3D7 0818000
gene id: 36329:PF3D7_0818000
uniprot id: C0H4V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

36329:PF3D7 0709300
gene id: 36329:PF3D7_0709300
uniprot id: Q8IBZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

36329:PF3D7 0208600
gene id: 36329:PF3D7_0208600
uniprot id: O96173
names: Similarity
messages: Belongs to the RRF family.

36329:PF3D7 0317400
gene id: 36329:PF3D7_0317400
uniprot id: O77383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS2/PSF2 family.
messages: Nucleus

36329:PF3D7 0508200
gene id: 36329:PF3D7_0508200
uniprot id: C0H4D2
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1211000
gene id: 36329:PF3D7_1211000
uniprot id: Q8I5U0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

36329:PF3D7 0204500
gene id: 36329:PF3D7_0204500
uniprot id: O96142
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

36329:PF3D7 0822300
gene id: 36329:PF3D7_0822300
uniprot id: Q8IB57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

36329:PF3D7 0820200
gene id: 36329:PF3D7_0820200
uniprot id: Q8IB37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

36329:PF3D7 0529500
gene id: 36329:PF3D7_0529500
uniprot id: Q8I3H2
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 1460400
gene id: 36329:PF3D7_1460400
uniprot id: Q8IKM8
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the peptidase C12 family.
messages: Expressed during the parasite blood stage, in schizonts (at protein level).
messages: Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8 (PubMed:17371404, PubMed:31658303, PubMed:20042598). Essential for parasite blood stage survival (PubMed:20042598).

36329:PF3D7 0718000
gene id: 36329:PF3D7_0718000
uniprot id: C0H4N5
names: Similarity
messages: Belongs to the dynein heavy chain family.

36329:PF3D7 0729100
gene id: 36329:PF3D7_0729100
uniprot id: C0H4Q1
names: Similarity
messages: Belongs to the allantoicase family.

36329:PF3D7 1432500
gene id: 36329:PF3D7_1432500
uniprot id: Q8ILD7
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

36329:PF3D7 0715800
gene id: 36329:PF3D7_0715800
uniprot id: Q8IBU2
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0801700
gene id: 36329:PF3D7_0801700
uniprot id: C0H4Y4
names: Similarity
messages: Belongs to the peptidase C48 family.

36329:PF3D7 0704900
gene id: 36329:PF3D7_0704900
uniprot id: Q8IC21
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

36329:PF3D7 0216800
gene id: 36329:PF3D7_0216800
uniprot id: O96246
names: Similarity
messages: Belongs to the TMEM121 family.

36329:PF3D7 1330700
gene id: 36329:PF3D7_1330700
uniprot id: A0A5K1K957
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0935300
gene id: 36329:PF3D7_0935300
uniprot id: Q8I2G7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

36329:PF3D7 1311300
gene id: 36329:PF3D7_1311300
uniprot id: Q8I6T7
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

36329:PF3D7 1341900
gene id: 36329:PF3D7_1341900
uniprot id: Q8IDS0
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

36329:PF3D7 1466300
gene id: 36329:PF3D7_1466300
uniprot id: Q8IKH3
names: Similarity
messages: Belongs to the proteasome subunit S1 family.

36329:PF3D7 0103800
gene id: 36329:PF3D7_0103800
uniprot id: Q8I2A2
names: Similarity
messages: Belongs to the actin family.

36329:PF3D7 0407500
gene id: 36329:PF3D7_0407500
uniprot id: C0H498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 1011400
gene id: 36329:PF3D7_1011400
uniprot id: Q8IJT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 1003700
gene id: 36329:PF3D7_1003700
uniprot id: Q8IK00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

36329:PF3D7 0718700
gene id: 36329:PF3D7_0718700
uniprot id: Q8IBR4
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1439000
gene id: 36329:PF3D7_1439000
uniprot id: Q8IL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

36329:PF3D7 1346700
gene id: 36329:PF3D7_1346700
uniprot id: Q8I6T1
names: Biotechnology
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell surface
messages: Gametocyte surface protein required for male fertility.
messages: Heterodimer; heterodimerizes with PF230.
messages: Promising transmission-blocking vaccine candidate: targeting the protein would prevent transmission of the parasite decreasing the malaria burden. However, efforts to produce full length recombinant protein in a functional conformation is difficult. Different approaches have been tested to produce a recombinant protein with display of its transmission-blocking epitopes.

36329:PF3D7 0725000
gene id: 36329:PF3D7_0725000
uniprot id: Q8IBK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

36329:PF3D7 1323800
gene id: 36329:PF3D7_1323800
uniprot id: A0A5K1K8G8
names: Similarity
messages: Belongs to the VPS52 family.

36329:PF3D7 1412000
gene id: 36329:PF3D7_1412000
uniprot id: Q8ILX4
names: Similarity
messages: Belongs to the nuclease type I family.

36329:PF3D7 0317500
gene id: 36329:PF3D7_0317500
uniprot id: O77382
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

36329:PF3D7 0613400
gene id: 36329:PF3D7_0613400
uniprot id: Q6LFD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: apicoplast

36329:PF3D7 1130500
gene id: 36329:PF3D7_1130500
uniprot id: Q8II59
names: Similarity
messages: Belongs to the COG2 family.

36329:PF3D7 1420700
gene id: 36329:PF3D7_1420700
uniprot id: Q8ILP3
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Expressed during parasite asexual blood stages, specifically at the schizont stage and in free merozoites (at protein level).
messages: Forms a complex composed of RH5, P113 and human BSG/basigin; the complex bridges the merozoite and host erythrocyte membranes (PubMed:28186186). Within the complex, interacts with RH5 (via N-terminus); the interaction tethers RH5 to the merozoite membrane (PubMed:28186186).
messages: Membrane receptor which tethers secreted RH5 to the merozoite membrane during merozoite invasion of host erythocytes.

36329:PF3D7 0605300
gene id: 36329:PF3D7_0605300
uniprot id: C6KSQ1
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

36329:PF3D7 0920800
gene id: 36329:PF3D7_0920800
uniprot id: Q8I2U5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

36329:PF3D7 1109400
gene id: 36329:PF3D7_1109400
uniprot id: Q8IIR2
names: Similarity
messages: Belongs to the bystin family.

36329:PF3D7 0320100
gene id: 36329:PF3D7_0320100
uniprot id: O97323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0408500
gene id: 36329:PF3D7_0408500
uniprot id: Q7K734
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA1 and PCNA2 (PubMed:26251451). Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

36329:PF3D7 1115900
gene id: 36329:PF3D7_1115900
uniprot id: Q8IIK6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

36329:PF3D7 0207800
gene id: 36329:PF3D7_0207800
uniprot id: O96165
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 0415400
gene id: 36329:PF3D7_0415400
uniprot id: Q8I1T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

36329:PF3D7 1419300
gene id: 36329:PF3D7_1419300
uniprot id: Q8ILQ7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin).
messages: Homodimer. In the absence of ligands two homodimers may interact to form a tetramer.
messages: Inhibited by chloroquine, cibacron blue, ferriprotoporphyrin IX (hemin) and S-hexylglutathione.

36329:PF3D7 1457300
gene id: 36329:PF3D7_1457300
uniprot id: Q8IKQ7
names: Similarity
messages: Belongs to the PDCD4 family.

36329:PF3D7 1350200
gene id: 36329:PF3D7_1350200
uniprot id: Q8IDJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

36329:PF3D7 0931900
gene id: 36329:PF3D7_0931900
uniprot id: C0H582
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it belongs to the adenylate kinase family, lacks several residues involved in ATP and AMP binding and has no adenylate kinase activity.
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm
messages: Lacks adenylate kinase activity.

36329:PF3D7 0516100
gene id: 36329:PF3D7_0516100
uniprot id: Q8I3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

36329:PF3D7 1242400
gene id: 36329:PF3D7_1242400
uniprot id: Q8I505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: cytoskeleton

36329:PF3D7 1215300
gene id: 36329:PF3D7_1215300
uniprot id: Q8I5Q3
names: Similarity
messages: Belongs to the GroES chaperonin family.

36329:PF3D7 1447000
gene id: 36329:PF3D7_1447000
uniprot id: Q8IL02
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

36329:PF3D7 1364100
gene id: 36329:PF3D7_1364100
uniprot id: Q8ID66
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell surface
messages: During the asexual blood stage, recruits host complement factor H CFH to the surface of merozoites resulting in the down-regulation of the host complement alternative pathway and thus, protecting merozoites from complement-mediated lysis.
messages: Expressed during the parasite blood stage, specifically in schizonts (at protein level).
messages: In strain D10, causes a loss of binding of human CFH to the merozoite surface resulting in a 7-fold increase in host complement-mediated merozoite lysis.
messages: Interacts with host complement factor CFH isoform 1 (via sushi 4-6 domains) and CFH isoform FHL-1 (via sushi 4-6 domains); this interaction recruits CFH onto the merozoite surface preventing complement-mediated cell lysis (PubMed:26700768). The interaction does not affect CFH activity (PubMed:26700768).

36329:PF3D7 0614900
gene id: 36329:PF3D7_0614900
uniprot id: C6KSZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

36329:PF3D7 1212600.1
gene id: 36329:PF3D7_1212600.1
uniprot id: C6S3K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1134800
gene id: 36329:PF3D7_1134800
uniprot id: Q8II16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

36329:PF3D7 1309100
gene id: 36329:PF3D7_1309100
uniprot id: Q8IEM3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

36329:PF3D7 1322000
gene id: 36329:PF3D7_1322000
uniprot id: Q8IE96
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

36329:PF3D7 1362200
gene id: 36329:PF3D7_1362200
uniprot id: Q8ID85
names: Similarity
messages: Belongs to the RuvB family.

36329:PF3D7 1208300
gene id: 36329:PF3D7_1208300
uniprot id: Q8I0V5
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.

36329:PF3D7 0614200
gene id: 36329:PF3D7_0614200
uniprot id: C6KSY3
names: Similarity
messages: Belongs to the NARF family.

36329:PF3D7 1026800
gene id: 36329:PF3D7_1026800
uniprot id: Q8IJD4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (By similarity).
messages: Component of the small ribosomal subunit (PubMed:24913268, PubMed:26432834). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).
messages: Cytoplasm
messages: Expressed during the asexual blood stage (at protein level).

36329:PF3D7 1331300
gene id: 36329:PF3D7_1331300
uniprot id: Q8IE14
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:18054093, PubMed:30127496). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
messages: Causes a reduction in parasite growth in the host erythrocyte (PubMed:30127496, PubMed:18054093). Reduces levels of the mature form of SERA5 but not of PEXEL-containing proteins (PubMed:30127496).
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11/SPC21 and three accessory subunits SPC25, SPC3/SPC22, SPC1/SPC12 (PubMed:30127496). Within the complex, interacts with SPC25 (PubMed:30127496). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). The complex interacts with the SEC61 channel-forming translocon complex and is involved in the import of classical signal sequence-containing proteins (PubMed:30127496).
messages: Endoplasmic reticulum membrane
messages: Expressed during the asexual blood stage, including ring, trophozoite and schizont stages (at protein level).
messages: Phosphorylated (PubMed:18054093). Phosphorylation increases catalytic activity (PubMed:18054093).
messages: Phosphorylation increases catalytic activity (PubMed:18054093). Ca(2+) slightly increases catalytic activity in vitro (PubMed:18054093).
messages: The C-terminal short (CTS) helix is essential for catalytic activity (By similarity). It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates (By similarity).

36329:PF3D7 0405200
gene id: 36329:PF3D7_0405200
uniprot id: Q8I1X7
names: Biotechnology
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Polymorphism
names: Subcellular Location Annotation
messages: Antibodies against CERLI2 severely reduces parasitemia, suggesting that CERLI2 is a potential vaccine candidate.
messages: Cell membrane
messages: During parasite asexual blood stages, expressed in trophozoites and at the schizont stage (at protein level).
messages: Host cell membrane
messages: Impairs merozoite invasion of host erythrocytes at, or prior to, the formation of the tight junction (PubMed:35140336). Merozoite development and egress following schizont rupture are not affected (PubMed:35140336). Inhibits rhoptry bulb RAP1 processing but not secretion of rhoptry neck proteins RH4 and RON4 (PubMed:35140336). Causes defects in rhoptry morphology which are narrower and more elongated (PubMed:35140336). No defect in microneme secretion (PubMed:35140336).
messages: Plays an important role in rhoptry physiology and thus is essential for merozoite invasion of host erythrocytes.
messages: The number of deca-peptide repeats in the C-terminus varies across P.falciparum strains (PubMed:19777263). Strain 3D7 has 12 copies; Dd2 has 14 copies; Hondura-1, FCC1, FCC2, and T996 have 17 copies; and strain D10 and FCR3 have 19 copies (PubMed:19777263).
messages: rhoptry membrane

36329:PF3D7 0420200
gene id: 36329:PF3D7_0420200
uniprot id: Q8I1N7
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

36329:PF3D7 0416400
gene id: 36329:PF3D7_0416400
uniprot id: C0H4A7
names: Similarity
messages: Belongs to the HAT1 family.

36329:PF3D7 1105700
gene id: 36329:PF3D7_1105700
uniprot id: Q8IIU6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

36329:PF3D7 1363300
gene id: 36329:PF3D7_1363300
uniprot id: A0A5K1K8K5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

36329:PF3D7 0413800
gene id: 36329:PF3D7_0413800
uniprot id: Q8I1U9
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

36329:PF3D7 1249500
gene id: 36329:PF3D7_1249500
uniprot id: Q8I4T9
names: Similarity
messages: Belongs to the CutA family.

36329:PF3D7 1361400
gene id: 36329:PF3D7_1361400
uniprot id: Q8ID92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin-binding proteins ADF family.
messages: Cytoplasm
messages: Interacts with monomeric actin, does not bind to actin polymers.
messages: Not involved in actin polymerisation, instead functions to stimulate nucleotide exchange on monomeric actin and influence turnover of the small amount of cytosolic actin microfilaments. Essential for erythrocytic schizogony (By similarity).
messages: cytoskeleton

36329:PF3D7 1342400
gene id: 36329:PF3D7_1342400
uniprot id: Q8IDR5
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Tetramer of two alpha and two beta subunits.

36329:PF3D7 0308600
gene id: 36329:PF3D7_0308600
uniprot id: O77325
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

36329:PF3D7 0828700
gene id: 36329:PF3D7_0828700
uniprot id: Q8IBB8
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0504400
gene id: 36329:PF3D7_0504400
uniprot id: Q8I457
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

36329:PF3D7 0703800
gene id: 36329:PF3D7_0703800
uniprot id: Q8IC32
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0810400
gene id: 36329:PF3D7_0810400
uniprot id: C0H4T7
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0322100
gene id: 36329:PF3D7_0322100
uniprot id: C0H484
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal TPase family.
messages: Nucleus

36329:PF3D7 0506200
gene id: 36329:PF3D7_0506200
uniprot id: Q8I440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

36329:PF3D7 0208200
gene id: 36329:PF3D7_0208200
uniprot id: O96169
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

36329:PF3D7 1314600
gene id: 36329:PF3D7_1314600
uniprot id: Q8IEG9
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (PubMed:17244193, PubMed:25116855, PubMed:28543853). In the mitochondrion, functions as a redox switch between two lipoylation routes (PubMed:25116855). Senses the oxidation state of lipoate and determines which downstream enzymes will be lipoylated (PubMed:25116855). In low reducing conditions, uses lipoate in its oxidized ring form to lipoylate glycine cleavage system H-protein GCVH (PubMed:17244193, PubMed:25116855, PubMed:28543853). In high reducing conditions and together with LipL2, uses reduced lipoate (dihydrolipoate) to lipoylate the E2 component of the branched chain alpha-ketoacid dehydrogenase complex BCKDH-E2/BCDH and the E2 component of the alpha-ketoglutarate dehydrogenase complex KDH. LipL1 is responsible for catalysing the activation of lipoate, forming lipoyl-AMP while LipL2 is required but is not capable of catalyzing this reaction (PubMed:17244193, PubMed:25116855).
messages: Expressed during the asexual blood stage, predominantly at the ring and schizont stages (at protein level).
messages: Inhibited by the lipoate analog 8-bromo-octanoate (BrO) (PubMed:17244193). Catalytic activity is increased in the presence of Mg(2+) (PubMed:17244193).
messages: Mitochondrion

36329:PF3D7 1233900
gene id: 36329:PF3D7_1233900
uniprot id: Q8I583
names: Similarity
messages: Belongs to the peptidase C48 family.

36329:PF3D7 0516300
gene id: 36329:PF3D7_0516300
uniprot id: Q8I3U5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

36329:PF3D7 0923600
gene id: 36329:PF3D7_0923600
uniprot id: Q8I2S0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: In the mitochondrion and together with LipL1, involved in the lipoylation of the E2 component of the branched chain alpha-ketoacid dehydrogenase complex BCKDH-E2/BCDH and the E2 component of the alpha -ketoglutarate dehydrogenase complex KDH (PubMed:25116855). LipL1 is responsible for catalysing the activation of lipoate, forming lipoyl-AMP while LipL2 is required but is not capable of catalyzing this reaction (PubMed:25116855). Although its role is unclear, it may catalyze the transfer of lipoyl groups from lipoyl-AMP to BCDH and KDH or act as an effector protein (PubMed:25116855).
messages: Lacks lipoate-protein ligase activity, probably due the loss of the lysine residue involved in the formation of the lipoyl-AMP reaction intermediate (PubMed:25116855). However, in some studies appears to be able to partially rescue ligase activity in E.coli lacking ligases lplA and lipB (PubMed:17244193, PubMed:18069893).
messages: Mitochondrion
messages: apicoplast

36329:PF3D7 0217800
gene id: 36329:PF3D7_0217800
uniprot id: O96258
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

36329:PF3D7 0931600
gene id: 36329:PF3D7_0931600
uniprot id: Q8I2J9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

36329:PF3D7 1126900
gene id: 36329:PF3D7_1126900
uniprot id: Q8II94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

36329:PF3D7 0212700
gene id: 36329:PF3D7_0212700
uniprot id: O96208
names: Similarity
messages: Belongs to the SRR1 family.

36329:PF3D7 0306400
gene id: 36329:PF3D7_0306400
uniprot id: O97245
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

36329:PF3D7 1459300
gene id: 36329:PF3D7_1459300
uniprot id: Q8IKN8
names: Similarity
messages: Belongs to the OPA3 family.

36329:PF3D7 1351600
gene id: 36329:PF3D7_1351600
uniprot id: Q8IDI4
names: Similarity
messages: Belongs to the FGGY kinase family.

36329:PF3D7 1444800
gene id: 36329:PF3D7_1444800
uniprot id: Q7KQL9
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Cytoplasm
messages: Expressed during parasite asexual blood stages, including in schizonts (at protein level).
messages: Homotetramer (PubMed:26289816). Interacts with TRAP (via cytoplasmic domain); the interaction prevents substrate binding and thereby inhibits aldolase activity (PubMed:26289816, PubMed:16321976) (Probable). Interacts with MTRAP (via cytoplasmic domain); MTRAP phosphorylation may increase the binding to FBPA (PubMed:16321976). Interact with RH1 (via cytoplasmic domain) (PubMed:22991428, PubMed:27607074). Interacts with RH2b (via cytoplasmic domain) (PubMed:22991428, PubMed:27607074). Interacts with RH4 (via cytoplasmic domain) (PubMed:22991428, PubMed:27607074). Interacts with AMA1 (via cytoplasmic domain); the interaction is weak, however it may be increased upon AMA1 phosphorylation (PubMed:27607074). Interacts with EBA140 (via cytoplasmic domain); the interaction is weak (PubMed:27607074). Interacts with EBA175 (via cytoplasmic domain); the interaction is weak (PubMed:27607074). Interacts with EBA181 (via cytoplasmic domain); the interaction is weak (PubMed:27607074). Interacts with G-actin and F-actin (PubMed:25261592). May interact with ACT2/actin II; the interaction inhibits FBPA catalytic activity (By similarity). Interacts with human SLC4A1/band 3 (via N-terminus); the interaction inhibits FBPA catalytic activity (By similarity).
messages: Host cell membrane
messages: Membrane
messages: Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:26289816). Independently of its catalytic activity, connects the actin filaments, and thus the actomyosin motor, to cell surface adhesins of the thrombospondin-related anonymous protein (TRAP), the erythrocyte binding ligand (EBL) and reticulocyte binding homolog (RH) protein families; this interaction is probably involved in transducing the motor force across the parasite surface required for sporozoite and ookinete gliding motility and merozoite invasion (PubMed:22991428, PubMed:25261592) (Probable). Stimulates actin polymerisation (PubMed:25261592).
messages: The cytoplasmic tail of TRAP and probably other adhesins acts as a competitive inhibitor as the binding sites of the glycolytic substrate fructose 1,6-bisphosphate and TRAP partially overlap.

36329:PF3D7 1310000
gene id: 36329:PF3D7_1310000
uniprot id: Q8IEL5
names: Similarity
messages: Belongs to the ATPase delta chain family.

36329:PF3D7 0316600
gene id: 36329:PF3D7_0316600
uniprot id: O77389
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

36329:PF3D7 1248000
gene id: 36329:PF3D7_1248000
uniprot id: A0A144A1E9
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.

36329:PF3D7 1426500
gene id: 36329:PF3D7_1426500
uniprot id: Q8ILJ9
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1248200
gene id: 36329:PF3D7_1248200
uniprot id: Q8I4V2
names: Biotechnology
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLT11 family.
messages: Involved in pre-mRNA splicing (By similarity). Binds RNA (By similarity).
messages: Nucleus
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: Probable component of the spliceosome C complex.
messages: The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.

36329:PF3D7 1422800
gene id: 36329:PF3D7_1422800
uniprot id: Q8ILM5
names: Similarity
messages: Belongs to the actin family.

36329:PF3D7 1430400
gene id: 36329:PF3D7_1430400
uniprot id: Q8ILG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation.
messages: Preautophagosomal structure membrane

36329:PF3D7 1111500
gene id: 36329:PF3D7_1111500
uniprot id: C6S3F0
names: Similarity
messages: Belongs to the acylphosphatase family.

36329:PF3D7 1207100
gene id: 36329:PF3D7_1207100
uniprot id: Q8I5X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

36329:PF3D7 1218300
gene id: 36329:PF3D7_1218300
uniprot id: Q8I5M5
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

36329:PF3D7 1020700
gene id: 36329:PF3D7_1020700
uniprot id: Q8IJJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

36329:PF3D7 1008400
gene id: 36329:PF3D7_1008400
uniprot id: Q8IJW0
names: Similarity
messages: Belongs to the AAA ATPase family.

36329:PF3D7 1468800
gene id: 36329:PF3D7_1468800
uniprot id: Q8IKE9
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1333200
gene id: 36329:PF3D7_1333200
uniprot id: Q8IDZ6
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

36329:PF3D7 1433300
gene id: 36329:PF3D7_1433300
uniprot id: Q8ILD0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0805400
gene id: 36329:PF3D7_0805400
uniprot id: C0H4R5
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

36329:PF3D7 1248500
gene id: 36329:PF3D7_1248500
uniprot id: Q8I4U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

36329:PF3D7 0908600
gene id: 36329:PF3D7_0908600
uniprot id: Q8I365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

36329:PF3D7 0412100
gene id: 36329:PF3D7_0412100
uniprot id: Q9U0G9
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

36329:PF3D7 0218000
gene id: 36329:PF3D7_0218000
uniprot id: O96260
names: Similarity
messages: Belongs to the activator 1 small subunits family.

36329:PF3D7 0810800
gene id: 36329:PF3D7_0810800
uniprot id: Q8IAU3
names: Similarity
messages: In the C-terminal section; belongs to the DHPS family.

36329:PF3D7 0716800
gene id: 36329:PF3D7_0716800
uniprot id: Q8IBT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

36329:PF3D7 1230400
gene id: 36329:PF3D7_1230400
uniprot id: Q8I5B6
names: Similarity
messages: Belongs to the peptidase T1B family. HslV subfamily.

36329:PF3D7 1468500.1
gene id: 36329:PF3D7_1468500.1
uniprot id: Q8IKF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

36329:PF3D7 0511700
gene id: 36329:PF3D7_0511700
uniprot id: Q8I3Y9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

36329:PF3D7 1251200
gene id: 36329:PF3D7_1251200
uniprot id: Q8I4S2
names: Similarity
messages: Belongs to the WD repeat coronin family.

36329:PF3D7 0503200
gene id: 36329:PF3D7_0503200
uniprot id: Q8I469
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

36329:PF3D7 1004000
gene id: 36329:PF3D7_1004000
uniprot id: Q8IJZ7
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

36329:PF3D7 1224000
gene id: 36329:PF3D7_1224000
uniprot id: Q8I5H7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

36329:PF3D7 0807500
gene id: 36329:PF3D7_0807500
uniprot id: Q8IAR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 1035000
gene id: 36329:PF3D7_1035000
uniprot id: Q8IJ59
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

36329:PF3D7 1475300
gene id: 36329:PF3D7_1475300
uniprot id: Q8IK85
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

36329:PF3D7 1444500
gene id: 36329:PF3D7_1444500
uniprot id: Q8IL26
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
messages: Auto-phosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
messages: Down-regulated at the ring stage by melatonin.
messages: Expressed during the asexual blood stage, including rings, trophozoites and schizonts.
messages: In blood stage parasites, phosphorylates translation factor eIF2alpha in response to amino acid starvation (PubMed:19435497, PubMed:29241041). During the asexual blood stage, involved in the response to the host hormone melatonin which is used by the parasite to modulate its cell cycle (PubMed:32702775).
messages: No defect in erythrocyte asexual growth and gametocytogenesis (PubMed:19435497). No defect in the production of sporozoites in the mosquito vector (PubMed:19435497). In blood stage parasites, phosphorylation of eIF2alpha in response to amino-acid starvation is impaired (PubMed:19435497). During the asexual blood stage, increased in parasitemia induced by host melatonin is impaired (PubMed:32702775).

36329:PF3D7 1247600
gene id: 36329:PF3D7_1247600
uniprot id: A0A144A0S1
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

36329:PF3D7 1231500
gene id: 36329:PF3D7_1231500
uniprot id: Q8I5A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus

36329:PF3D7 1414900
gene id: 36329:PF3D7_1414900
uniprot id: Q8ILU7
names: Similarity
messages: Belongs to the peptidase S16 family.

36329:PF3D7 0218500
gene id: 36329:PF3D7_0218500
uniprot id: O96265
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

36329:PF3D7 1321600
gene id: 36329:PF3D7_1321600
uniprot id: B3FEM7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

36329:PF3D7 0519200
gene id: 36329:PF3D7_0519200
uniprot id: Q8I3R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Vacuole membrane

36329:PF3D7 0914200
gene id: 36329:PF3D7_0914200
uniprot id: Q8I310
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

36329:PF3D7 0307100
gene id: 36329:PF3D7_0307100
uniprot id: O97249
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS12 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).
messages: Component of the small ribosomal subunit (PubMed:24913268, PubMed:26432834). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).
messages: Cytoplasm
messages: Expressed during the asexual blood stage (at protein level).

36329:PF3D7 1034700
gene id: 36329:PF3D7_1034700
uniprot id: Q8IJ63
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

36329:PF3D7 0908300.1
gene id: 36329:PF3D7_0908300.1
uniprot id: C0H526
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plant tobamovirus multiplication TOM1 protein family.
messages: Membrane

36329:PF3D7 1345100
gene id: 36329:PF3D7_1345100
uniprot id: Q8IDP4
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family.
messages: Expressed during the parasite blood stage, including in rings, trophozoites, schizonts and merozoites (at protein level).
messages: Monomer (PubMed:25475729). Component of the Plasmodium translocon of exported proteins (PTEX) complex composed of HSP101, EXP2, PTEX150, PTEX88 and TRX2 (PubMed:19536257).
messages: Parasitophorous vacuole membrane
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:16910770, PubMed:22355694). As part of the translocon PTEX complex, plays a role in the export of parasite proteins into the host erythrocyte (By similarity). The translocon PTEX complex is a multi-protein machinery resident in the parasite parasitophorous vacuolar membrane, responsible for protein secretion into host cells (PubMed:19536257). May contribute to the unfolding of proteins containing the PEXEL localization motif before their passage through the translocon or regulate the PTEX complex function (PubMed:19536257).
messages: The disulfide bond between Cys-82 and Cys-85 acts as a redox-active center and is reduced by thioredoxin reductase TRXR.

36329:PF3D7 1234800
gene id: 36329:PF3D7_1234800
uniprot id: Q8I574
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1302600
gene id: 36329:PF3D7_1302600
uniprot id: Q8I701
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

36329:PF3D7 1145300
gene id: 36329:PF3D7_1145300
uniprot id: C6S3G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

36329:PF3D7 1457700
gene id: 36329:PF3D7_1457700
uniprot id: Q8IKQ3
names: Similarity
messages: Belongs to the CBF/MAK21 family.

36329:PF3D7 0824600
gene id: 36329:PF3D7_0824600
uniprot id: C0H4X5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

36329:PF3D7 0629700
gene id: 36329:PF3D7_0629700
uniprot id: C6KTD2
names: Biotechnology
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: Probable histone methyltransferase.
messages: constitutive pattern of expression.

36329:PF3D7 0109300
gene id: 36329:PF3D7_0109300
uniprot id: Q8I251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

36329:PF3D7 1133300
gene id: 36329:PF3D7_1133300
uniprot id: Q8II31
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

36329:PF3D7 1406100
gene id: 36329:PF3D7_1406100
uniprot id: Q8IM33
names: Similarity
messages: Belongs to the TUB family.

36329:PF3D7 1003300
gene id: 36329:PF3D7_1003300
uniprot id: Q8IK04
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

36329:PF3D7 0111900
gene id: 36329:PF3D7_0111900
uniprot id: Q8I227
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

36329:PF3D7 0417200
gene id: 36329:PF3D7_0417200
uniprot id: Q8I1R6
names: Function
names: Similarity
names: Subunit
messages: Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the thymidylate synthase family.
messages: In the N-terminal section; belongs to the dihydrofolate reductase family.

36329:PF3D7 1472100
gene id: 36329:PF3D7_1472100
uniprot id: Q8IKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

36329:PF3D7 0923000
gene id: 36329:PF3D7_0923000
uniprot id: Q8I2S6
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

36329:PF3D7 1317800
gene id: 36329:PF3D7_1317800
uniprot id: C0H5C2
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

36329:PF3D7 0520900
gene id: 36329:PF3D7_0520900
uniprot id: P50250
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

36329:PF3D7 0322300
gene id: 36329:PF3D7_0322300
uniprot id: O97295
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1430700
gene id: 36329:PF3D7_1430700
uniprot id: Q8ILF7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

36329:PF3D7 1441900
gene id: 36329:PF3D7_1441900
uniprot id: Q8IL51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

36329:PF3D7 1449400
gene id: 36329:PF3D7_1449400
uniprot id: Q8IKY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

36329:PF3D7 0418500
gene id: 36329:PF3D7_0418500
uniprot id: Q8I1Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

36329:PF3D7 1455900
gene id: 36329:PF3D7_1455900
uniprot id: C6S3J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

36329:PF3D7 1439900
gene id: 36329:PF3D7_1439900
uniprot id: Q7KQM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic and gluconeogenic pathways.
messages: Homodimer.

36329:PF3D7 0107700
gene id: 36329:PF3D7_0107700
uniprot id: B9ZSI6
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1146000
gene id: 36329:PF3D7_1146000
uniprot id: Q8IHQ8
names: Subcellular Location Annotation
messages: nucleolus

36329:PF3D7 1431600
gene id: 36329:PF3D7_1431600
uniprot id: Q8ILE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

36329:PF3D7 1022300
gene id: 36329:PF3D7_1022300
uniprot id: Q8IJI1
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1340500
gene id: 36329:PF3D7_1340500
uniprot id: A0A5K1K8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Nucleus
messages: spindle

36329:PF3D7 0625000.1
gene id: 36329:PF3D7_0625000.1
uniprot id: C6KT86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

36329:PF3D7 1126400
gene id: 36329:PF3D7_1126400
uniprot id: Q8IIA0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1311100
gene id: 36329:PF3D7_1311100
uniprot id: Q8IEK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus

36329:PF3D7 0919700
gene id: 36329:PF3D7_0919700
uniprot id: Q8I2V6
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

36329:PF3D7 1115700
gene id: 36329:PF3D7_1115700
uniprot id: Q8I6U4
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 1249900
gene id: 36329:PF3D7_1249900
uniprot id: A0A144A0V8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0806600
gene id: 36329:PF3D7_0806600
uniprot id: C0H4S3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

36329:PF3D7 0103400
gene id: 36329:PF3D7_0103400
uniprot id: Q8I2A6
names: Biotechnology
names: Cofactor
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1404100
gene id: 36329:PF3D7_1404100
uniprot id: Q8IM53
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

36329:PF3D7 1445900
gene id: 36329:PF3D7_1445900
uniprot id: Q8IL13
names: Similarity
messages: Belongs to the DEAD box helicase family.

36329:PF3D7 1012500
gene id: 36329:PF3D7_1012500
uniprot id: Q8IJS0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

36329:PF3D7 0813600
gene id: 36329:PF3D7_0813600
uniprot id: Q8IAX2
names: Similarity
messages: Belongs to the DENR family.

36329:PF3D7 1405600
gene id: 36329:PF3D7_1405600
uniprot id: Q8IM38
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

36329:PF3D7 1331600
gene id: 36329:PF3D7_1331600
uniprot id: C0H5F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Membrane

36329:PF3D7 1402400
gene id: 36329:PF3D7_1402400
uniprot id: Q8IM65
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0903700
gene id: 36329:PF3D7_0903700
uniprot id: Q6ZLZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

36329:PF3D7 0316800
gene id: 36329:PF3D7_0316800
uniprot id: O77395
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

36329:PF3D7 0828600
gene id: 36329:PF3D7_0828600
uniprot id: Q8IBB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

36329:PF3D7 0718500
gene id: 36329:PF3D7_0718500
uniprot id: Q8IBR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

36329:PF3D7 1235700
gene id: 36329:PF3D7_1235700
uniprot id: Q8I0V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

36329:PF3D7 1020900
gene id: 36329:PF3D7_1020900
uniprot id: Q7KQL3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive GDP-bound form and an active GTP-bound form (PubMed:32144363). Intrinsic GTPase activity is almost undetectable in vitro (By similarity). Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by GTPase-activating protein ARFGAP1 (PubMed:32144363).
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Golgi apparatus membrane
messages: May interact with GTPase RAB5b.
messages: Small GTPase involved in protein trafficking between different compartments (PubMed:21045287). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Regulates the transport of N-acylated AK2 to the parasitophorous vacuole membrane (PubMed:33604307). May be involved in the activation of lipid kinase PIP5K (PubMed:19171150).

36329:PF3D7 1367700
gene id: 36329:PF3D7_1367700
uniprot id: Q8ID31
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

36329:PF3D7 0302900
gene id: 36329:PF3D7_0302900
uniprot id: O77312
names: Similarity
messages: Belongs to the exportin family.

36329:PF3D7 0103200
gene id: 36329:PF3D7_0103200
uniprot id: Q8I2A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

36329:PF3D7 0720000
gene id: 36329:PF3D7_0720000
uniprot id: Q8IBQ2
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 0306200
gene id: 36329:PF3D7_0306200
uniprot id: O97244
names: Similarity
messages: Belongs to the AHA1 family.

36329:PF3D7 1458900
gene id: 36329:PF3D7_1458900
uniprot id: Q8IKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

36329:PF3D7 0423800
gene id: 36329:PF3D7_0423800
uniprot id: Q8IFM8
names: Biotechnology
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of the PfRH5 adhesion complex composed of 1 copy of CyRPA, RH5 and RIPR; the complex is formed during merozoite invasion of host erythrocytes specifically at the interface between the parasite and host membranes (PubMed:25583518, PubMed:27374406, PubMed:30542156). Following the establishment of the junction between the merozoite and the erythrocyte, CyRPA dissociates from the complex (PubMed:30542156). Within the complex, interacts with RH5 and RIPR (PubMed:28195530, PubMed:30542156). CyRPA recruits RIPR to RH5-P113-BSG complex; the formation of the PfRH5 adhesion complex increases the affinity of RH5 for BSG and probably leads to the release of RH5 from P113 while maintaining the interaction of the PfRH5 adhesion complex with BSG (PubMed:28186186, PubMed:30542156).
messages: Conditional knockdown causes loss of cell growth and severely impairs merozoite invasion of erythrocytes. Attachment to and deformation of erythrocyte membrane is normal, however the subsequent step, which triggers an increase in Ca(2+) from the attached merozoite into the erythrocyte, is impaired.
messages: CyRPA shares structural homology with sialidases, however the 3 conserved arginine residues involved in substrate binding and the nucleophilic tyrosine residue are not conserved. Does not have sialidase/neuraminidase activity in vitro.
messages: CyRPA was thought to be GPI-anchored to the merozoite membrane (PubMed:25583518). However, a subsequent report shows that this was not the case (PubMed:27374406).
messages: Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:22593616, PubMed:25583518, PubMed:27374406, PubMed:28195530, PubMed:28195038). Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes (PubMed:25583518, PubMed:28186186, PubMed:28195530, PubMed:28195038, PubMed:30542156). This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte (PubMed:27374406, PubMed:28186186, PubMed:30542156).
messages: Expressed during parasite asexual blood stages, specifically at the schizont stage, in free merozoites, and at the very early ring stage but not in late ring and early trophozoite stages (at protein level).
messages: Host cell membrane
messages: N-glycosylated.
messages: Potential candidate for the development of parasite blood stage vaccines. In vitro and in vivo, induces neutralizing antibodies capable of inhibiting merozoite invasion of host erythrocytes.
messages: Secreted
messages: microneme lumen

36329:PF3D7 1345700
gene id: 36329:PF3D7_1345700
uniprot id: Q8I6T2
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

36329:PF3D7 1008700
gene id: 36329:PF3D7_1008700
uniprot id: Q7KQL5
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (Probable). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells (Probable). Interacts with DCX/apicortin; the interaction stabilizes microtubule assembly (PubMed:33633135).
messages: Expressed during the parasite blood stage, including in trophozoites, schizonts and free merozoites (at protein level).
messages: Tamoxifen used to treat breast cancer blocks the interaction between apicortin and, alpha-tubulin 1 and beta-tubulin resulting in microtubule destabilization.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:33633135). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

36329:PF3D7 1138600
gene id: 36329:PF3D7_1138600
uniprot id: Q8IHX9
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0512200
gene id: 36329:PF3D7_0512200
uniprot id: Q8I3Y4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

36329:PF3D7 1011700
gene id: 36329:PF3D7_1011700
uniprot id: Q8IJS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

36329:PF3D7 1108700
gene id: 36329:PF3D7_1108700
uniprot id: Q8IIR6
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1105100
gene id: 36329:PF3D7_1105100
uniprot id: Q8IIV1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

36329:PF3D7 1366800
gene id: 36329:PF3D7_1366800
uniprot id: C0H5K9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1203500
gene id: 36329:PF3D7_1203500
uniprot id: Q8I610
names: Similarity
messages: Belongs to the SUA5 family.

36329:PF3D7 1139300
gene id: 36329:PF3D7_1139300
uniprot id: Q8IHX2
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1461500
gene id: 36329:PF3D7_1461500
uniprot id: C6S3J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

36329:PF3D7 0619900
gene id: 36329:PF3D7_0619900
uniprot id: C6KT39
names: Similarity
messages: Belongs to the SF3A2 family.

36329:PF3D7 1222400
gene id: 36329:PF3D7_1222400
uniprot id: Q8I5J1
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0930300
gene id: 36329:PF3D7_0930300
uniprot id: Q8I0U8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

36329:PF3D7 0511500
gene id: 36329:PF3D7_0511500
uniprot id: Q8I3Z1
names: Biotechnology
names: Developmental Stage
names: Subcellular Location Annotation
messages: Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0519000
gene id: 36329:PF3D7_0519000
uniprot id: Q8I3R9
names: Similarity
messages: Belongs to the SLBP family.

36329:PF3D7 0418100
gene id: 36329:PF3D7_0418100
uniprot id: Q8I1Q6
names: Similarity
messages: Belongs to the SAPS family.

36329:PF3D7 1242600
gene id: 36329:PF3D7_1242600
uniprot id: Q8I503
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

36329:PF3D7 0408300
gene id: 36329:PF3D7_0408300
uniprot id: Q9U0K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus

36329:PF3D7 1429100
gene id: 36329:PF3D7_1429100
uniprot id: Q8ILH3
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

36329:PF3D7 1358700
gene id: 36329:PF3D7_1358700
uniprot id: Q8IDB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

36329:PF3D7 1367600
gene id: 36329:PF3D7_1367600
uniprot id: Q8ID32
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

36329:PF3D7 0812700
gene id: 36329:PF3D7_0812700
uniprot id: Q8IAW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

36329:PF3D7 0515100
gene id: 36329:PF3D7_0515100
uniprot id: Q8I3V7
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0207100
gene id: 36329:PF3D7_0207100
uniprot id: O96160
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1007900
gene id: 36329:PF3D7_1007900
uniprot id: Q8IJW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

36329:PF3D7 1434600
gene id: 36329:PF3D7_1434600
uniprot id: Q8ILB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

36329:PF3D7 1119500
gene id: 36329:PF3D7_1119500
uniprot id: Q8IIH2
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

36329:PF3D7 0526500
gene id: 36329:PF3D7_0526500
uniprot id: Q8I3K0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1321500.1
gene id: 36329:PF3D7_1321500.1
uniprot id: Q8I6Z7
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed during the asexual blood stage, with highest levels in the late schizont stage.
messages: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:30794532). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:30794532). By regulating cAMP levels during the asexual blood stage and, thus PKA activation, required for merozoite invasion of erythrocytes and for the parasite development immediately following invasion (PubMed:30794532).

36329:PF3D7 1132400
gene id: 36329:PF3D7_1132400
uniprot id: Q8II41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

36329:PF3D7 1205900
gene id: 36329:PF3D7_1205900
uniprot id: Q8I5Y6
names: Similarity
messages: Belongs to the TMCO4 family.

36329:PF3D7 0205500
gene id: 36329:PF3D7_0205500
uniprot id: O96150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

36329:PF3D7 1107900
gene id: 36329:PF3D7_1107900
uniprot id: Q8IIS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

36329:PF3D7 0404500
gene id: 36329:PF3D7_0404500
uniprot id: Q8I1Y4
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Attenuated parasites that cannot commit to infection, even when they encounter with hepatocytes, resulting in continuous traversal of hepatocytes.
messages: Cell membrane
messages: Cell surface
messages: Involved in sporozoite infection of hepatocytes and replication therein.

36329:PF3D7 0826700
gene id: 36329:PF3D7_0826700
uniprot id: Q8IBA0
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

36329:PF3D7 1217600
gene id: 36329:PF3D7_1217600
uniprot id: Q8I5N2
names: Similarity
messages: Belongs to the APC10 family.

36329:PF3D7 1107400
gene id: 36329:PF3D7_1107400
uniprot id: Q8IIS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.
messages: Nucleus

36329:PF3D7 0214200
gene id: 36329:PF3D7_0214200
uniprot id: O96222
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

36329:PF3D7 1132500
gene id: 36329:PF3D7_1132500
uniprot id: Q8II40
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0514000
gene id: 36329:PF3D7_0514000
uniprot id: C0H4D8
names: Similarity
messages: Belongs to the tubulin--tyrosine ligase family.

36329:PF3D7 0708000
gene id: 36329:PF3D7_0708000
uniprot id: C0H4M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

36329:PF3D7 1460900.1
gene id: 36329:PF3D7_1460900.1
uniprot id: Q8IKM3
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

36329:PF3D7 0909400
gene id: 36329:PF3D7_0909400
uniprot id: Q8I358
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

36329:PF3D7 1339800
gene id: 36329:PF3D7_1339800
uniprot id: Q8IDT7
names: Similarity
messages: Belongs to the MOZART1 family.

36329:PF3D7 0519100
gene id: 36329:PF3D7_0519100
uniprot id: C0H4F0
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

36329:PF3D7 1342000
gene id: 36329:PF3D7_1342000
uniprot id: Q8IDR9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

36329:PF3D7 1470500
gene id: 36329:PF3D7_1470500
uniprot id: Q8IKD3
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Expressed during the asexual blood stage, probably in gametocytes.
messages: Impaired gametogenesis (PubMed:18452584). Gametocytes are morphologically normal up to and including stage V of development; however, gametocytes fail to round up upon stimulation of gametogenesis with xanthurenic acid and levels of exflagellation are severely reduced (PubMed:18452584). Higher levels of intracellular cGMP in stages III to V gametocytes (PubMed:18452584).
messages: Membrane
messages: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:18452584). Probably by regulating cGMP levels, required for activation of gametogenesis (PubMed:18452584).

36329:PF3D7 1407500
gene id: 36329:PF3D7_1407500
uniprot id: Q8IM19
names: Similarity
messages: Belongs to the TRM112 family.

36329:PF3D7 0209300
gene id: 36329:PF3D7_0209300
uniprot id: P62368
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: In the mevalonate-independent isoprenoid biosynthetic pathway, converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP.
messages: apicoplast

36329:PF3D7 1306300
gene id: 36329:PF3D7_1306300
uniprot id: C0H5A2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

36329:PF3D7 1309500
gene id: 36329:PF3D7_1309500
uniprot id: Q8I700
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

36329:PF3D7 0624700
gene id: 36329:PF3D7_0624700
uniprot id: C6KT83
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

36329:PF3D7 1004800
gene id: 36329:PF3D7_1004800
uniprot id: Q8IJY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 1456900
gene id: 36329:PF3D7_1456900
uniprot id: Q8IKR0
names: Similarity
messages: Belongs to the UPF0235 family.

36329:PF3D7 1345200
gene id: 36329:PF3D7_1345200
uniprot id: A0A5K1K8X1
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0603700
gene id: 36329:PF3D7_0603700
uniprot id: C6KSN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

36329:PF3D7 1138500
gene id: 36329:PF3D7_1138500
uniprot id: Q8IHY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Enzyme with a broad specificity.
messages: Membrane

36329:PF3D7 1135000.1
gene id: 36329:PF3D7_1135000.1
uniprot id: Q8II14
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0802200
gene id: 36329:PF3D7_0802200
uniprot id: Q8IAM2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

36329:PF3D7 1225100
gene id: 36329:PF3D7_1225100
uniprot id: Q8I5G6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 1202700
gene id: 36329:PF3D7_1202700
uniprot id: Q8I618
names: Similarity
messages: Belongs to the AATF family.

36329:PF3D7 1033900
gene id: 36329:PF3D7_1033900
uniprot id: Q8IJ70
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 1407900
gene id: 36329:PF3D7_1407900
uniprot id: Q7KQM4
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity.
messages: Expressed during the asexual blood stage including in trophozoites (at protein level).
messages: Inhibited by KNI derived compounds KNI-10333 and to a lesser extent KNI-10743.
messages: Membrane
messages: No growth defect (PubMed:15513918). However, slight decrease in proliferation and slight increase in doubling time during the asexual blood stage in an amino acid-limited medium (PubMed:15513918).
messages: Not N-glycosylated.
messages: Proteolytically cleaved into the soluble active mature form in the digestive vacuole by cysteine protease falcipains; the process begins at the early ring stage (PubMed:14709539). Proteolysis requires an acidic environment (By similarity).
messages: Vacuole lumen
messages: Vacuole membrane

36329:PF3D7 0719300
gene id: 36329:PF3D7_0719300
uniprot id: Q8IBQ9
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

36329:PF3D7 0925400
gene id: 36329:PF3D7_0925400
uniprot id: Q8I2Q4
names: Similarity
messages: Belongs to the PPP phosphatase family.

36329:PF3D7 0210600
gene id: 36329:PF3D7_0210600
uniprot id: O96188
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Conditional knockout at the ring stage has no effect on parasite development during the first cycle and merozoites egress normally from host erythrocytes. However, these merozoites are unable to reinvade new erythrocytes (PubMed:31492901, PubMed:32179747). Impaired rhoptry secretion during merozoite invasion of host erythrocytes (PubMed:31492901, PubMed:32179747). Increases the spatial segregation between rhoptry neck protein RON4 and bulb protein RAP1, and impairs RAP1 processing (PubMed:32179747). No effect on rhoptry morphology (PubMed:31492901, PubMed:32179747). Microneme secretion is not affected (PubMed:31492901).
messages: During parasite asexual blood stages, expressed at the late schizont stage and in free merozoites (at protein level).
messages: Essential for merozoite invasion of host cells by controlling rhoptry secretion (PubMed:31492901, PubMed:32179747). Binds to phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate (PIP2) lipids and thus, likely contributes to the assembly of the machinery that docks or primes the rhoptry to the parasite cell membrane prior to the fusion with the host cell membrane (PubMed:31492901).
messages: The C2 domain is a non-calcium binding domain (By similarity). Cooperates with the PH domain in the binding to phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate (PIP2) (By similarity).
messages: The PH domain cooperates with the C2 domain in the binding to phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: rhoptry membrane

36329:PF3D7 0919200
gene id: 36329:PF3D7_0919200
uniprot id: Q8I2W1
names: Similarity
messages: Belongs to the DeSI family.

36329:PF3D7 1446700
gene id: 36329:PF3D7_1446700
uniprot id: Q8IL06
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0809700
gene id: 36329:PF3D7_0809700
uniprot id: Q8IAT2
names: Similarity
messages: Belongs to the RuvB family.

36329:PF3D7 0715500
gene id: 36329:PF3D7_0715500
uniprot id: Q8IBU5
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

36329:PF3D7 0934400
gene id: 36329:PF3D7_0934400
uniprot id: Q8I2H4
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0603400
gene id: 36329:PF3D7_0603400
uniprot id: Q6LFN2
names: Biotechnology
names: Developmental Stage
messages: Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1037100
gene id: 36329:PF3D7_1037100
uniprot id: Q8IJ37
names: Similarity
messages: Belongs to the pyruvate kinase family.

36329:PF3D7 0611200
gene id: 36329:PF3D7_0611200
uniprot id: C6KSV7
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1142600
gene id: 36329:PF3D7_1142600
uniprot id: Q8IHT9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

36329:PF3D7 1109900
gene id: 36329:PF3D7_1109900
uniprot id: Q8I713
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

36329:PF3D7 1357100
gene id: 36329:PF3D7_1357100
uniprot id: Q8I0P6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

36329:PF3D7 0409100
gene id: 36329:PF3D7_0409100
uniprot id: C0H4A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

36329:PF3D7 0925700
gene id: 36329:PF3D7_0925700
uniprot id: Q7K6A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

36329:PF3D7 0211500
gene id: 36329:PF3D7_0211500
uniprot id: O96195
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0420400
gene id: 36329:PF3D7_0420400
uniprot id: Q8IFQ7
names: Similarity
messages: Belongs to the RRF family.

36329:PF3D7 0628300.1
gene id: 36329:PF3D7_0628300.1
uniprot id: C6KTB9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

36329:PF3D7 1438900
gene id: 36329:PF3D7_1438900
uniprot id: Q8IL80
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

36329:PF3D7 1435500
gene id: 36329:PF3D7_1435500
uniprot id: Q8ILA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

36329:PF3D7 0308000
gene id: 36329:PF3D7_0308000
uniprot id: O77321
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

36329:PF3D7 1464700
gene id: 36329:PF3D7_1464700
uniprot id: Q8IKJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

36329:PF3D7 1462800
gene id: 36329:PF3D7_1462800
uniprot id: Q8IKK7
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

36329:PF3D7 0520000
gene id: 36329:PF3D7_0520000
uniprot id: Q8I3R0
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

36329:PF3D7 1341200
gene id: 36329:PF3D7_1341200
uniprot id: Q8IDS6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

36329:PF3D7 0415900
gene id: 36329:PF3D7_0415900
uniprot id: C0H4A6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

36329:PF3D7 0423600
gene id: 36329:PF3D7_0423600
uniprot id: Q8IFN0
names: Biotechnology
names: Developmental Stage
names: Subcellular Location Annotation
messages: Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1426000
gene id: 36329:PF3D7_1426000
uniprot id: Q8ILK3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

36329:PF3D7 0921000.1
gene id: 36329:PF3D7_0921000.1
uniprot id: Q8I2U3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 1342700
gene id: 36329:PF3D7_1342700
uniprot id: Q8IDR2
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

36329:PF3D7 1431800
gene id: 36329:PF3D7_1431800
uniprot id: Q8ILE7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

36329:PF3D7 1446800
gene id: 36329:PF3D7_1446800
uniprot id: Q8IL04
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the hemozoin formation complex (HFC) composed of falcipain 2, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN (PubMed:23471987). The HFC complex is involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage (PubMed:23471987). Interacts with falcipain 2; the interaction is direct and enhances HDP catalytic activity (PubMed:23471987). Interacts with host hemoglobin (PubMed:28949547).
messages: Expressed during the asexual blood stage including in trophozoites (at protein level).
messages: HDP is critical for survival, suggesting it could be a potential malaria drug target.
messages: Heme detoxifying enzyme that converts heme to crystalline hemozoin (beta-hematin) to protect the organism from the toxic effects of heme (PubMed:18437218, PubMed:23471987, PubMed:25138161, PubMed:28949547). During its development, P.falciparum proteolyzes vast amounts of host hemoglobin, leading to heme release (PubMed:18437218).
messages: Vacuole
messages: host cytosol

36329:PF3D7 1147700
gene id: 36329:PF3D7_1147700
uniprot id: Q8IHP4
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

36329:PF3D7 1460700
gene id: 36329:PF3D7_1460700
uniprot id: Q8IKM5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

36329:PF3D7 1324800
gene id: 36329:PF3D7_1324800
uniprot id: Q8IE69
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

36329:PF3D7 0708400
gene id: 36329:PF3D7_0708400
uniprot id: Q8IC05
names: Similarity
messages: Belongs to the heat shock protein 90 family.

36329:PF3D7 1417600
gene id: 36329:PF3D7_1417600
uniprot id: Q8ILR9
names: Biotechnology
names: Subcellular Location Annotation
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0708300
gene id: 36329:PF3D7_0708300
uniprot id: Q8IC06
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

36329:PF3D7 1141400
gene id: 36329:PF3D7_1141400
uniprot id: Q8IHV1
names: Similarity
messages: Belongs to the PIGH family.

36329:PF3D7 1016300
gene id: 36329:PF3D7_1016300
uniprot id: Q8I6U8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell surface
messages: Host cytoplasm
messages: Interacts with host glycophorin.
messages: Involved in merozoite invasion of host erythrocytes.
messages: Secreted
messages: The PEXEL motif is involved in the protein translocation through the parasitophorous vacuole membrane and into the host erythrocyte cytoplasm.

36329:PF3D7 1128700
gene id: 36329:PF3D7_1128700
uniprot id: Q8II76
names: Function
names: Similarity
messages: Belongs to the peptidase C13 family.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

36329:PF3D7 1438000
gene id: 36329:PF3D7_1438000
uniprot id: Q8IL87
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

36329:PF3D7 1223600
gene id: 36329:PF3D7_1223600
uniprot id: Q8I5I1
names: Biotechnology
names: Developmental Stage
names: Subcellular Location Annotation
messages: Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0518400
gene id: 36329:PF3D7_0518400
uniprot id: Q7K6A7
names: Similarity
messages: Belongs to the cyclin family.

36329:PF3D7 0915400
gene id: 36329:PF3D7_0915400
uniprot id: Q8I2Z8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha (regulatory) and two beta (catalytic) chains.

36329:PF3D7 0924000
gene id: 36329:PF3D7_0924000
uniprot id: Q8I2R7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 1315600
gene id: 36329:PF3D7_1315600
uniprot id: C0H5B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

36329:PF3D7 1472900
gene id: 36329:PF3D7_1472900
uniprot id: Q8IKA9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.

36329:PF3D7 1205700
gene id: 36329:PF3D7_1205700
uniprot id: Q8I5Y8
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

36329:PF3D7 1407100
gene id: 36329:PF3D7_1407100
uniprot id: Q8IM23
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

36329:PF3D7 1355800
gene id: 36329:PF3D7_1355800
uniprot id: C0H5I5
names: Similarity
messages: Belongs to the SF3B5 family.

36329:PF3D7 1440200
gene id: 36329:PF3D7_1440200
uniprot id: Q8IL68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

36329:PF3D7 1461900
gene id: 36329:PF3D7_1461900
uniprot id: Q8IKL5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 0911400
gene id: 36329:PF3D7_0911400
uniprot id: Q8I338
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

36329:PF3D7 1124000
gene id: 36329:PF3D7_1124000
uniprot id: Q8IIC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

36329:PF3D7 1209500.1
gene id: 36329:PF3D7_1209500.1
uniprot id: Q8I5V4
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 1 Mg(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium (By similarity). Binds magnesium less tightly than zinc (By similarity).
messages: Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium (By similarity). Tightly binds zinc (By similarity).
messages: Expressed at the ring stage during the asexual blood stage.
messages: Knockouts at the asexual blood stage are viable and have normal merozoite formation in the host erythrocytes (PubMed:18590734). cGMP hydrolysis is reduced by about 20% with no effect on cAMP hydrolysis (PubMed:18590734).
messages: Membrane
messages: Not inhibited by cAMP (PubMed:18590734). Inhibited by zaprinast (PubMed:16038615, PubMed:18590734).
messages: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.

36329:PF3D7 1466100
gene id: 36329:PF3D7_1466100
uniprot id: Q8IKH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. BSU subfamily.
messages: Nucleus

36329:PF3D7 1328800
gene id: 36329:PF3D7_1328800
uniprot id: Q8IE47
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Expressed during the asexual blood stage, specifically during the trophozoite and schizont stages (at protein level) (PubMed:18397290, PubMed:22379140). Not detected at the ring stage (PubMed:18397290).
messages: Homotrimer. Dissociates into monomers on binding NAD.
messages: Inhibited by nicotinamide. Inhibited by surfactin, which is a competitive inhibitor of NAD and an uncompetitive inhibitor of acetylated peptide.
messages: Loss of binding to telomers and subtelomeric repeat regions (TAREs) and promoters of var genes.
messages: NAD-dependent protein deacylase (PubMed:21992006). Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues (PubMed:21992006). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo (PubMed:17827348, PubMed:18729382, PubMed:18397290, PubMed:18221799, PubMed:20601220, PubMed:21992006). Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis (PubMed:15820676, PubMed:22379140). Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance (PubMed:19402747). Involved in recruiting ORC1 to the telomers and subtelomeric repeat regions (TAREs) and promoters of var genes (PubMed:22379140). Can ADP-ribosylate both histones and itself (PubMed:17827348). May also have a role in telomeric end protection (PubMed:18525026).
messages: Nucleus
messages: The reported ADP-ribosyltransferase activity of sirtuins is likely to be some inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: nucleolus
messages: telomere

36329:PF3D7 0807900
gene id: 36329:PF3D7_0807900
uniprot id: Q8IAR7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 0219500
gene id: 36329:PF3D7_0219500
uniprot id: O96270
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

36329:PF3D7 0727500
gene id: 36329:PF3D7_0727500
uniprot id: Q8IBI2
names: Similarity
messages: Belongs to the mTERF family.

36329:PF3D7 1146600
gene id: 36329:PF3D7_1146600
uniprot id: Q8IHQ2
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

36329:PF3D7 1342100
gene id: 36329:PF3D7_1342100
uniprot id: Q8IDR8
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

36329:PF3D7 0721600
gene id: 36329:PF3D7_0721600
uniprot id: Q8IBN5
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

36329:PF3D7 1315700
gene id: 36329:PF3D7_1315700
uniprot id: Q8IEF7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.

36329:PF3D7 0610400
gene id: 36329:PF3D7_0610400
uniprot id: C6KSV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

36329:PF3D7 1347100
gene id: 36329:PF3D7_1347100
uniprot id: Q8IDM7
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

36329:PF3D7 0628200
gene id: 36329:PF3D7_0628200
uniprot id: C6KTB8
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auto-phosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
messages: Dissociation from BIP and oligomerization, may results autophosphorylation and kinase activity induction.
messages: During the asexual blood stage, phosphorylates translation factor eIF2alpha in late schizonts resulting in protein translation inhibition (PubMed:22355110, PubMed:29241041). Plays a role in trophozoite differentiation into schizonts (PubMed:29241041).
messages: Endoplasmic reticulum membrane
messages: Expressed during the asexual blood stage (at protein level).
messages: May form oligomers in response to stress; oligomerization may result in catalytic activity (PubMed:29241041). Interacts with BIP; the interaction is disrupted in response to stress (By similarity).
messages: Smaller forms of 80-90kDa appear to be present in the asexual blood stage suggesting that the protein may be proteolytically cleaved (By similarity). They localize to the cytoplasm in schizonts, to organelles in all blood stages and to the host erythrocyte membrane during schizont segmentation (By similarity).

36329:PF3D7 0604200
gene id: 36329:PF3D7_0604200
uniprot id: C6KSP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

36329:PF3D7 0612900
gene id: 36329:PF3D7_0612900
uniprot id: C6KSX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

36329:PF3D7 1223300
gene id: 36329:PF3D7_1223300
uniprot id: Q8I0X3
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

36329:PF3D7 0203300
gene id: 36329:PF3D7_0203300
uniprot id: O96136
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

36329:PF3D7 1423300
gene id: 36329:PF3D7_1423300
uniprot id: Q8ILL9
names: Similarity
messages: Belongs to the PPP phosphatase family.

36329:PF3D7 1332800
gene id: 36329:PF3D7_1332800
uniprot id: Q8IE00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

36329:PF3D7 1438600
gene id: 36329:PF3D7_1438600
uniprot id: Q8IL82
names: Similarity
messages: Belongs to the GET4 family.

36329:PF3D7 0905900
gene id: 36329:PF3D7_0905900
uniprot id: Q8I390
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

36329:PF3D7 0606700
gene id: 36329:PF3D7_0606700
uniprot id: C6KSR5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

36329:PF3D7 1425700
gene id: 36329:PF3D7_1425700
uniprot id: Q8ILK6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0525100
gene id: 36329:PF3D7_0525100
uniprot id: Q8I3L4
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

36329:PF3D7 1224500
gene id: 36329:PF3D7_1224500
uniprot id: Q8I5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

36329:PF3D7 1307600
gene id: 36329:PF3D7_1307600
uniprot id: Q8IEN9
names: Function
names: Similarity
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

36329:PF3D7 1125300
gene id: 36329:PF3D7_1125300
uniprot id: Q8IIB0
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

36329:PF3D7 1032800
gene id: 36329:PF3D7_1032800
uniprot id: C6S3E1
names: Similarity
messages: Belongs to the SDS22 family.

36329:PF3D7 1206600
gene id: 36329:PF3D7_1206600
uniprot id: Q8I5X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: apicoplast

36329:PF3D7 0907400
gene id: 36329:PF3D7_0907400
uniprot id: Q8I377
names: Similarity
messages: Belongs to the ClpX chaperone family. HslU subfamily.

36329:PF3D7 1008900
gene id: 36329:PF3D7_1008900
uniprot id: Q8IJV6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:15478799). Has very low activity with CTP, GTP, ITP and UTP and no activity with GMP, CMP, UMP or IMP in vitro (PubMed:15478799).
messages: Cytoplasm
messages: Inhibited by the dinucleoside pentaphosphate compound P1,P5-di(adenosine-5') pentaphosphate (AP5A).

36329:PF3D7 0507400
gene id: 36329:PF3D7_0507400
uniprot id: C0H4D0
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Acts as a specific inhibitor of subtilisin-like protease SUB1.
messages: Cell membrane
messages: Expressed during the parasite blood stage, specifically in schizonts (at protein level).
messages: Parasitophorous vacuole lumen
messages: Secreted

36329:PF3D7 1139700
gene id: 36329:PF3D7_1139700
uniprot id: Q8IHW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

36329:PF3D7 1235000
gene id: 36329:PF3D7_1235000
uniprot id: Q8I572
names: Similarity
messages: Belongs to the PIH1 family.

36329:PF3D7 1213800
gene id: 36329:PF3D7_1213800
uniprot id: Q8I5R7
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (PubMed:25817387, PubMed:27798837). Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro) (PubMed:14663147). Has no activity on correctly charged Pro-tRNA(Pro) or Ala-tRNA(Ala) (PubMed:14663147).
messages: Consists of four domains: the N-terminal editing domain, the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension (Probable). The first domain (about residues 1-163) is required for editing of incorrectly charged tRNA (PubMed:14663147). When it is deleted the enzyme shows pronounced misacylation of tRNA(Pro) with alanine (PubMed:14663147).
messages: Cytoplasm
messages: Expressed during the asexual blood stage including at the ring stage and in trophozoites and schizonts (at protein level).
messages: Homodimer.
messages: Inhibited by the quinazolinone-based compound febrifugine from the Chinese plant Dichroa febrifuga which is used to treat malaria-associated fever (PubMed:25817387, PubMed:27798837). Also inhibited by febrifugine derivatives such as halofuginone (PubMed:25817387, PubMed:27798837).

36329:PF3D7 1115400
gene id: 36329:PF3D7_1115400
uniprot id: Q8IIL0
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 0203000
gene id: 36329:PF3D7_0203000
uniprot id: O96133
names: Biotechnology
names: Developmental Stage
names: Subcellular Location Annotation
messages: Expressed during the asexual blood stage.
messages: Host cell membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0509500
gene id: 36329:PF3D7_0509500
uniprot id: Q8I409
names: Similarity
messages: Belongs to the EME1/MMS4 family.

36329:PF3D7 0322000
gene id: 36329:PF3D7_0322000
uniprot id: Q76NN7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

36329:PF3D7 1110900
gene id: 36329:PF3D7_1110900
uniprot id: Q8IIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

36329:PF3D7 1366500
gene id: 36329:PF3D7_1366500
uniprot id: Q8ID43
names: Similarity
messages: Belongs to the NDK family.

36329:PF3D7 1422000
gene id: 36329:PF3D7_1422000
uniprot id: C6S3H9
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0932400
gene id: 36329:PF3D7_0932400
uniprot id: Q8I2J2
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

36329:PF3D7 1353600
gene id: 36329:PF3D7_1353600
uniprot id: Q76NM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity).

36329:PF3D7 0921400
gene id: 36329:PF3D7_0921400
uniprot id: Q8I2T9
names: Similarity
messages: Belongs to the NifU family.

36329:PF3D7 0615300
gene id: 36329:PF3D7_0615300
uniprot id: C6KSZ4
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0113300
gene id: 36329:PF3D7_0113300
uniprot id: Q9U0M8
names: Biotechnology
names: Subcellular Location Annotation
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0529000
gene id: 36329:PF3D7_0529000
uniprot id: Q8I3H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIP family.
messages: May protect the parasite against attack by the host immune system by immunomodulation.
messages: Membrane

36329:PF3D7 0308200
gene id: 36329:PF3D7_0308200
uniprot id: O77323
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

36329:PF3D7 1026400
gene id: 36329:PF3D7_1026400
uniprot id: Q8IJD7
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

36329:PF3D7 0809500
gene id: 36329:PF3D7_0809500
uniprot id: C0H4T2
names: Similarity
messages: Belongs to the EAF6 family.

36329:PF3D7 0204400
gene id: 36329:PF3D7_0204400
uniprot id: C6S3A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

36329:PF3D7 1140500
gene id: 36329:PF3D7_1140500
uniprot id: Q8IHW0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

36329:PF3D7 0626300
gene id: 36329:PF3D7_0626300
uniprot id: C6KT99
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

36329:PF3D7 0923800.1
gene id: 36329:PF3D7_0923800.1
uniprot id: P61076
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins (PubMed:9368022, PubMed:11013257, PubMed:16910770, PubMed:23845423). Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO (PubMed:11013257). Has no catalytic activity towards oxidized glutathione (GSSG) (PubMed:11013257).
messages: Cytoplasm
messages: Homodimer.
messages: In Plasmodium, the C-terminal redox center, which acts as the active site, is formed by two cysteines while in mammalian TRXR this redox center is composed of a cysteine-selenocysteine active site.
messages: Mitochondrion
messages: Produced by alternative initiation at Met-77 of isoform 1.

36329:PF3D7 1037300
gene id: 36329:PF3D7_1037300
uniprot id: Q8IJ34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

36329:PF3D7 0935200
gene id: 36329:PF3D7_0935200
uniprot id: Q8I2G8
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

36329:PF3D7 1224600
gene id: 36329:PF3D7_1224600
uniprot id: Q8I5H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 1133800
gene id: 36329:PF3D7_1133800
uniprot id: Q8II27
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0309600
gene id: 36329:PF3D7_0309600
uniprot id: O00806
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.
messages: Phosphorylated.
messages: Plays an important role in the elongation step of protein synthesis.

36329:PF3D7 1235800
gene id: 36329:PF3D7_1235800
uniprot id: Q8I565
names: Similarity
messages: Belongs to the peptidase M14 family.

36329:PF3D7 1310600
gene id: 36329:PF3D7_1310600
uniprot id: Q76NM7
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive GDP-bound form and an active GTP-bound form (By similarity). Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs) (By similarity).
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Expressed during the asexual blood stage, including the trophozoite and schizont stages (at protein level).
messages: Interacts with CK1 (PubMed:22188458). May interact with ARF1 (PubMed:33604307).
messages: Lacks the C-terminal cysteine motifs subject to isoprenylation present in mammalian RAB5B homolog.
messages: May be palmitoylated on Cys-3.
messages: Myristoylation is required for cell membrane and food vacuole membrane localization.
messages: Small GTPase which regulates vesicle trafficking between organelles (Probable). May be involved in the trafficking of the N-myristoylated AK2 from the endoplasmic reticulum to the parasitophorous vacuole membrane (PubMed:27316546).
messages: Vacuole membrane
messages: Vesicle

36329:PF3D7 1327800
gene id: 36329:PF3D7_1327800
uniprot id: Q8IE40
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

36329:PF3D7 0910600
gene id: 36329:PF3D7_0910600
uniprot id: Q8I346
names: Similarity
messages: Belongs to the synaptobrevin family.

36329:PF3D7 1453300
gene id: 36329:PF3D7_1453300
uniprot id: C6S3J4
names: Similarity
messages: Belongs to the YOS1 family.

36329:PF3D7 0209400
gene id: 36329:PF3D7_0209400
uniprot id: C6S3B4
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

36329:PF3D7 1130000
gene id: 36329:PF3D7_1130000
uniprot id: Q8II63
names: Similarity
messages: Belongs to the phosphohexose mutase family.

36329:PF3D7 0527300
gene id: 36329:PF3D7_0527300
uniprot id: Q8I3J2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

36329:PF3D7 0705100
gene id: 36329:PF3D7_0705100
uniprot id: Q8IC19
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1203000
gene id: 36329:PF3D7_1203000
uniprot id: Q8I615
names: Biotechnology
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) (By similarity). Interacts (via PIP-box) with PCNA1; the interaction occurs during DNA replication in trophozoites (PubMed:18554328, PubMed:19633266).
messages: Component of the origin recognition complex (ORC) that binds origins of replication and thus may regulate the initiation of DNA replication (Probable). DNA-binding may not be ATP-dependent (PubMed:19633266). In a SIR2A/Sir2-dependent manner, binds to and silences telomers and subtelomeric repeat regions (TAREs) (PubMed:18525026, PubMed:22379140, PubMed:24018145). In a SIR2A/Sir2-dependent manner, binds to promoters of var genes localized next to TAREs resulting in their silencing (PubMed:22379140).
messages: Expressed during the asexual blood stage, specifically during the late trophozoite and early schizont stages (at protein level) (PubMed:16216221, PubMed:18525026, PubMed:18554328, PubMed:19633266, PubMed:22379140, PubMed:26094711). Some expression has been found also at the ring stage (at protein level) (PubMed:18525026, PubMed:18554328, PubMed:22379140, PubMed:26094711). Highly expressed during the sexual blood stage (PubMed:12543146).
messages: In schizonts, may be phosphorylated by PK5; phosphorylation leads to ORC1 dissociation from the telomeres and var gene promoters, translocation to the cytoplasm, where it is degraded by the proteasome.
messages: Leucine heptad repeats are essential for the binding to telomeric DNA.
messages: Nucleus
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: The C-terminal domain binds ATP and is required for the binding to DNA replication origin sites.
messages: The N-terminal domain binds telomeric DNA and is required for the silencing of telomers and var genes.
messages: nucleolus
messages: telomere

36329:PF3D7 1356200
gene id: 36329:PF3D7_1356200
uniprot id: Q8IDE0
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1438400
gene id: 36329:PF3D7_1438400
uniprot id: Q8IL84
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C14B family.
messages: Ca(2+) does not appear to affect catalytic activity.
messages: Cytoplasm
messages: Expressed during the parasite blood stage, specifically in schizonts, and gametocytes (at protein level).
messages: In contrast to other metacaspases of the peptidase C14B family, the catalytic histidine and cysteine residues do not appear to be conserved.
messages: Protease that cleaves specifically after arginine or lysine residues (PubMed:29317266, PubMed:32202613). May play a role in parasite growth and/or development (PubMed:29317266, PubMed:32202613).
messages: Up-regulated by oxidative stress.

36329:PF3D7 0320900
gene id: 36329:PF3D7_0320900
uniprot id: O97320
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

36329:PF3D7 0310000
gene id: 36329:PF3D7_0310000
uniprot id: Q9NLA7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

36329:PF3D7 0513400
gene id: 36329:PF3D7_0513400
uniprot id: C0H4D6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

36329:PF3D7 1125400
gene id: 36329:PF3D7_1125400
uniprot id: Q8IIA9
names: Similarity
messages: Belongs to the Tim44 family.

36329:PF3D7 0918100
gene id: 36329:PF3D7_0918100
uniprot id: C0H542
names: Similarity
messages: Belongs to the cytochrome b5 family.

36329:PF3D7 0802300
gene id: 36329:PF3D7_0802300
uniprot id: Q8IAM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

36329:PF3D7 1203700
gene id: 36329:PF3D7_1203700
uniprot id: Q8I608
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

36329:PF3D7 0307500
gene id: 36329:PF3D7_0307500
uniprot id: O97253
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

36329:PF3D7 1345900
gene id: 36329:PF3D7_1345900
uniprot id: A0A5K1K999
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

36329:PF3D7 1139500.1
gene id: 36329:PF3D7_1139500.1
uniprot id: Q8IHX1
names: Similarity
messages: Belongs to the AAA ATPase family. PCH2 subfamily.

36329:PF3D7 1463300
gene id: 36329:PF3D7_1463300
uniprot id: Q8IKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

36329:PF3D7 1432700
gene id: 36329:PF3D7_1432700
uniprot id: A0A144A3E6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

36329:PF3D7 1219600
gene id: 36329:PF3D7_1219600
uniprot id: Q8I5L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

36329:PF3D7 1225500
gene id: 36329:PF3D7_1225500
uniprot id: Q8I5G2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

36329:PF3D7 0613300
gene id: 36329:PF3D7_0613300
uniprot id: C6KSX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Membrane

36329:PF3D7 0815900
gene id: 36329:PF3D7_0815900
uniprot id: Q8IAZ6
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

36329:PF3D7 1340800
gene id: 36329:PF3D7_1340800
uniprot id: Q8IDS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 0528500
gene id: 36329:PF3D7_0528500
uniprot id: Q8I3I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

36329:PF3D7 0919000
gene id: 36329:PF3D7_0919000
uniprot id: Q8I2W3
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

36329:PF3D7 1439700
gene id: 36329:PF3D7_1439700
uniprot id: Q8IL72
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

36329:PF3D7 1315100
gene id: 36329:PF3D7_1315100
uniprot id: Q8IEG4
names: Similarity
messages: Belongs to the protein kinase superfamily.

36329:PF3D7 1239500
gene id: 36329:PF3D7_1239500
uniprot id: Q8I528
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

36329:PF3D7 0828000
gene id: 36329:PF3D7_0828000
uniprot id: A0A5K1K8S0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

36329:PF3D7 1132600
gene id: 36329:PF3D7_1132600
uniprot id: Q8II38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

36329:PF3D7 0318100
gene id: 36329:PF3D7_0318100
uniprot id: O77376
names: Similarity
messages: Belongs to the band 7/mec-2 family.

36329:PF3D7 0315100
gene id: 36329:PF3D7_0315100
uniprot id: O97266
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

36329:PF3D7 1362100
gene id: 36329:PF3D7_1362100
uniprot id: A0A5K1K948
names: Similarity
messages: Belongs to the 14-3-3 family.

36329:PF3D7 0602500
gene id: 36329:PF3D7_0602500
uniprot id: C6KSM5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

36329:PF3D7 1420000
gene id: 36329:PF3D7_1420000
uniprot id: Q8ILQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

36329:PF3D7 0320800
gene id: 36329:PF3D7_0320800
uniprot id: O97285
names: Similarity
messages: Belongs to the DEAD box helicase family.

36329:PF3D7 0113900
gene id: 36329:PF3D7_0113900
uniprot id: Q8I2D9
names: Biotechnology
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By binding to host chemokine CX3CL1, mediates the cytoadherence of host erythrocytes infected with parasite mature forms (late trophozoite and schizont) to endothelial cells, which sequesters them away from the circulation and thus prevents their elimination by the host spleen.
messages: Expressed during the asexual blood stage in late rings, trophozoites and schizonts (at protein level) (PubMed:27653778, PubMed:32184257). Expressed in gametocytes from stages I to IV (at protein level) (PubMed:27653778, PubMed:20332084).
messages: Host cell membrane
messages: Host cytoplasmic vesicle membrane
messages: Monomer (PubMed:27653778). May form homodimers or homotrimers (PubMed:27653778). Interacts with MAHRP1 (PubMed:32184257). Interacts (via extracellular domain) with human chemokine CX3CL1; the interaction mediates the adhesion of infected erythrocytes with endothelial cells (PubMed:27653778).
messages: Potential vaccine candidate as CBP1-based peptides or antibodies against CBP1 prevents adhesion of infected erythrocytes to endothelial cells.
messages: The P.falciparum Export Element (PEXEL) motif, also known as the vacuolar transport signal (VTS), is a pentameric sequence (RxLxE/Q/D) required for the translocation of proteins across the parasitophorous vacuole membrane (Probable). In the endoplasmic reticulum, the motif is cleaved after the leucine residue and the N-terminus is N-acetylated (PubMed:20332084).

36329:PF3D7 0625600
gene id: 36329:PF3D7_0625600
uniprot id: C6KT92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

36329:PF3D7 0821700
gene id: 36329:PF3D7_0821700
uniprot id: Q8IB51
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

36329:PF3D7 1232400
gene id: 36329:PF3D7_1232400
uniprot id: Q8I598
names: Similarity
messages: Belongs to the CWC16 family.

36329:PF3D7 1202200
gene id: 36329:PF3D7_1202200
uniprot id: Q8I623
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 0908800
gene id: 36329:PF3D7_0908800
uniprot id: Q8I364
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 1446400
gene id: 36329:PF3D7_1446400
uniprot id: Q8IL09
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

36329:PF3D7 1317100
gene id: 36329:PF3D7_1317100
uniprot id: Q8IEE5
names: Similarity
messages: Belongs to the MCM family.

36329:PF3D7 1465900
gene id: 36329:PF3D7_1465900
uniprot id: Q8IKH8
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

36329:PF3D7 0207400
gene id: 36329:PF3D7_0207400
uniprot id: O96163
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 1318400
gene id: 36329:PF3D7_1318400
uniprot id: Q8IED2
names: Biotechnology
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: May play a role in the conversion of interphase chromatin into condensed chromosomes.
messages: Nucleus
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with smc4 forming a V-shaped heterodimer.

36329:PF3D7 0418700
gene id: 36329:PF3D7_0418700
uniprot id: Q8I1Q0
names: Similarity
messages: Belongs to the NOB1 family.

36329:PF3D7 1416500
gene id: 36329:PF3D7_1416500
uniprot id: Q8ILT0
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

36329:PF3D7 1315800
gene id: 36329:PF3D7_1315800
uniprot id: Q8IEF6
names: Biotechnology
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed throughout the erythrocytic development of the infected host, low expression in rings and schizonts, high levels in trophozoites.
messages: Nucleus
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: Transcriptional activator. Has a role in the parasite erythrocytic cycle where it directly regulates key genes involved in cell cycle regulation and progression. Binds directly to Myb regulatory elements.
messages: dsRNA causes reduced expression, alters parasite growth and trophozoite to schizont transition during the erythrocytic cycle.

36329:PF3D7 0616000
gene id: 36329:PF3D7_0616000
uniprot id: C6KT01
names: Similarity
messages: Belongs to the pyridoxine kinase family.

36329:PF3D7 1141600
gene id: 36329:PF3D7_1141600
uniprot id: Q8IHU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

36329:PF3D7 1114700
gene id: 36329:PF3D7_1114700
uniprot id: Q8IIL5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.

36329:PF3D7 0933800
gene id: 36329:PF3D7_0933800
uniprot id: Q8I2I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

36329:PF3D7 0402300
gene id: 36329:PF3D7_0402300
uniprot id: P86148
names: Biotechnology
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: During the asexual blood stage, binds to a sialic acid containing receptor on the surface of the host erythrocyte and thus is involved in merozoite invasion (PubMed:18617995). Binds erythrocytes via a neuraminidase sensitive and trypsin-, chymotrypsin-resistant receptor (PubMed:11733572, PubMed:18617995). After merozoite attachment and reorientation, RH1 binding to its erythrocyte receptor triggers an increase in intracellular Ca(2+) within the parasite resulting in the release of microneme proteins such as EBA175 which in turn leads to the formation of the tight junction between parasite and host cell (PubMed:24280897).
messages: Expressed during parasite asexual blood stages, specifically at the late schizont stage prior to merozoite release and in free merozoites (at protein level) (PubMed:11733572, PubMed:12228308, PubMed:15612925). Expression levels are low in isolate 3D7 when compared to other isolates (at protein level) (PubMed:12228308, PubMed:15612925, PubMed:18617995).
messages: May in part interact with AMA1 in the moving tight junction between the parasite and the erythrocyte membranes; the interaction may facilitate junction formation and active invasion.
messages: No difference in the ability to invade neuraminidase-, trypsin or chymotrypsin-treated host erythrocytes compared with wild-type.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera (PubMed:17653272). Antibodies against the erythrocyte binding domain (EBD) prevent merozoite invasion of host erythrocytes (PubMed:18617995, PubMed:24280897). However, inhibition efficiency varies across isolates due to the variation in RH1 expression levels and can also be affected by the expression levels of RH2a and/or RH2b, two other erythrocyte binding receptors (PubMed:18617995). Isolates 3D7 or HB3 are insensitive to antibodies against EBD while isolates W2mef, T994, FCR3 and Dd2 are sensitive (PubMed:18617995, PubMed:24280897).
messages: Proteolytically processed into multiple fragments following schizont rupture (PubMed:19614665, PubMed:32452132). In the mature schizont stage prior to merozoite release, full length RH1 is processed post-Golgi into a 240 kDa N-terminal form and a 120 kDa C-terminal form containing the transmembrane region (PubMed:12228308, PubMed:15612925, PubMed:19614665, PubMed:32452132). Both forms appear not to form a complex (PubMed:19614665). However, they appear to remain in close proximity in late schizonts (PubMed:32452132). Following merozoite invasion of host erythrocytes, the 240 kDa form is further processed into a 140 kDa form which may be involved in the disengagement of the ligand-receptor complex required during the invasion process (PubMed:19614665, PubMed:32452132). Also, the 120 kDa is further cleaved into a 110 kDa form and a transmembrane 9 kDa form probably by ROM4 (PubMed:17040128, PubMed:19614665, PubMed:32452132).
messages: RH1 expression levels greatly vary between isolates in part due to multiple RH1 gene copies; levels are high in isolates W2mef, FCR3, FCB1 and T994, and low in isolates 3D7, HB3, K1, 7G8, T996 and Dd2 (PubMed:12228308, PubMed:15612925, PubMed:18617995). A similar variation in expression affects other reticulocyte-binding proteins such as RH2a and RH2b (PubMed:12228308). The expression pattern of RH1 and RH2 allows the strain to use different invasion pathways to enter erythrocytes (Probable). This provides a mechanism of phenotypic variation to evade host immune responses and to adapt to the polymorphic nature of the erythrocyte receptors in human populations (Probable).
messages: Secreted
messages: rhoptry
messages: tight junction

36329:PF3D7 1353400
gene id: 36329:PF3D7_1353400
uniprot id: Q8IDG6
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1137100
gene id: 36329:PF3D7_1137100
uniprot id: Q8IHZ4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

36329:PF3D7 0607400
gene id: 36329:PF3D7_0607400
uniprot id: C6KSS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

36329:PF3D7 0216400
gene id: 36329:PF3D7_0216400
uniprot id: O96243
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

36329:PF3D7 1203900
gene id: 36329:PF3D7_1203900
uniprot id: Q8I607
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 1336900
gene id: 36329:PF3D7_1336900
uniprot id: Q8IDW3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 1430200
gene id: 36329:PF3D7_1430200
uniprot id: Q8ILG2
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autocleaved into a p55 mature form.
messages: Belongs to the peptidase A1 family.
messages: During the asexual blood stage, initiates the proteolytic maturation of several rhoptry proteins and thus, is required for merozoite invasion of host erythrocytes and probably the subsequent development of the ring-stage (PubMed:29074775, PubMed:32109369). Cleaves rhoptry associated protein 1 RAP1 and apical sushi protein ASP during schizont maturation (PubMed:29074775, PubMed:32109369). Also cleaves rhoptry protein RON3 (PubMed:32109369).
messages: Expressed during the asexual blood stage, in schizonts and free merozoites (at protein level).
messages: Inhibited by small molecule 49c (PubMed:29074775). Inhibited by small molecule WM382 (PubMed:32109369).
messages: It is unclear if PMIX is glycosylated as other members of the same enzyme family, i.e. PMI and PMII, are not.
messages: Membrane
messages: Normal asexual development in host erythrocytes (PubMed:29074775). Egress from erythrocytes is normal; however, subsequent erythrocyte invasion by newly released merozoites is severely impaired (PubMed:29074775). Accumulation of RAP1 p86 precursor resulting from impaired processing (PubMed:29074775). Impaired ASP processing (PubMed:29074775). Impaired secretion of CyRPA during merozoite egress from erythrocytes (PubMed:29074775).
messages: rhoptry

36329:PF3D7 1346100
gene id: 36329:PF3D7_1346100
uniprot id: Q8IDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

36329:PF3D7 1330600
gene id: 36329:PF3D7_1330600
uniprot id: Q8IE20
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

36329:PF3D7 0934500
gene id: 36329:PF3D7_0934500
uniprot id: Q8I2H3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

36329:PF3D7 1036800
gene id: 36329:PF3D7_1036800
uniprot id: Q8IJ40
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0920100
gene id: 36329:PF3D7_0920100
uniprot id: C0H546
names: Similarity
messages: Belongs to the HscB family.

36329:PF3D7 1408600
gene id: 36329:PF3D7_1408600
uniprot id: Q8IM10
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

36329:PF3D7 0729200
gene id: 36329:PF3D7_0729200
uniprot id: Q5MYR6
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

36329:PF3D7 0219200
gene id: 36329:PF3D7_0219200
uniprot id: O96269
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS30 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).
messages: Component of the small ribosomal subunit (PubMed:24913268, PubMed:26432834). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).
messages: Cytoplasm
messages: Expressed during the asexual blood stage (at protein level).

36329:PF3D7 1010000
gene id: 36329:PF3D7_1010000
uniprot id: Q8IJU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

36329:PF3D7 1120000
gene id: 36329:PF3D7_1120000
uniprot id: Q8IIG7
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1365700
gene id: 36329:PF3D7_1365700
uniprot id: Q8ID52
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1419800.1
gene id: 36329:PF3D7_1419800.1
uniprot id: O15770
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Maintains high levels of reduced glutathione in the cytosol.
messages: Produced by alternative initiation at Met-47 of isoform 2.
messages: The active site is a redox-active disulfide bond.
messages: apicoplast

36329:PF3D7 1450900
gene id: 36329:PF3D7_1450900
uniprot id: Q8IKW7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

36329:PF3D7 1247900
gene id: 36329:PF3D7_1247900
uniprot id: Q8I4V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

36329:PF3D7 1324500
gene id: 36329:PF3D7_1324500
uniprot id: Q8IE72
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.

36329:PF3D7 1018800
gene id: 36329:PF3D7_1018800
uniprot id: Q8IJL4
names: Similarity
messages: Belongs to the RMD1/sif2 family.

36329:PF3D7 1246200
gene id: 36329:PF3D7_1246200
uniprot id: Q8I4X0
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A potassium ion appears to reside in the active site during hydrolysis and leaves together with the inorganic phosphate Pi. K(+) does not activate Pi release; however, it may be relevant for ATP hydrolysis.
messages: ACT1 and ACT2 differ in their polymerization, filament stability and helical structure (PubMed:24743229). Unlike mammalian actin, Apicomplexa actins do not form long and stable filaments (PubMed:24743229).
messages: ATP hydrolysis occurs in the polymeric state (PubMed:24743229). Unlike for mammalian actin, ATP hydrolysis occurs also in the monomeric form and the release of inorganic phosphate (Pi) is more efficient (PubMed:24743229).
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm (PubMed:24743229, PubMed:28923924, PubMed:31199804). Polymerizes into shorter and less stable actin filaments compared to ACT2/actin-2; this is thought to facilitate gliding motility and host cell invasion (PubMed:24743229, PubMed:28923924). Has ATPase activity (PubMed:24743229, PubMed:31199804). ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi (Probable). ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin (Probable). Plays an essential role during the asexual blood stage (PubMed:28810863). At the segmented schizont stage, required for apicoplast migration and segregation into individual daughter merozoites (PubMed:28810863). Also, required for the separation of daughter merozoites in the final stages of cytokinesis (PubMed:28810863). Essential for merozoite invasion of, but not adhesion to or reorientation towards, host erythrocytes (PubMed:28810863).
messages: Belongs to the actin family.
messages: Conditional knockout at the ring stage results in the production of merozoites; however, these merozoites fail to start a new infection cycle due to a failure to invade new host erythrocytes (PubMed:28810863). During schizogony, daughter merozoite development and segmentation is abnormal and is characterized by the presence of aberrant membranous pockets adjacent to the food vacuole (PubMed:28810863). Apicoplasts have few branches and collapse close to the food vacuole failing to migrate to individual daughter cells (PubMed:28810863). No defect in secretory organelles or mitochondria and the formation of Maurer's clefts in the host cytoplasm is normal (PubMed:28810863). Egress from host erythrocytes is normal; however, some merozoites stayed conjoined, remaining connected to each other and to the central food vacuole (PubMed:28810863). No defect in microneme secretion (PubMed:28810863). Merozoite attachment to the host erythrocyte, reorientation and secretion of RON proteins are normal (PubMed:28810863). However, the formation of the circular junction between the parasite and host cell membranes is impaired and merozoites are incapable of deforming and invading host erythrocytes (PubMed:28810863). Production of gametocytes is normal (PubMed:28810863).
messages: Cytoplasm
messages: Expressed during the asexual blood stage, including in trophozoites, schizonts and merozoites (at protein level) (PubMed:28810863). Expression increases at the late trophozoite stage (at protein level) (PubMed:28810863).
messages: Monomer (G-actin) (PubMed:24743229). Oligomer (F-actin) (PubMed:24743229, PubMed:28923924). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:24743229, PubMed:28923924). Unlike for mammalian monomeric actin, parasite monomeric actin is able to induce oligomerization in the presence of ATP or ADP (PubMed:24743229). Mg(2+), which is used to coordinate ATP, is required for polymerization (PubMed:24743229). Interacts with MyoA (PubMed:33767187). Interacts with DNase I with low affinity (By similarity).
messages: Nucleus
messages: cytoskeleton

36329:PF3D7 0730300
gene id: 36329:PF3D7_0730300
uniprot id: Q8IBF6
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0922500
gene id: 36329:PF3D7_0922500
uniprot id: P27362
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

36329:PF3D7 1235200
gene id: 36329:PF3D7_1235200
uniprot id: Q8I570
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1423600
gene id: 36329:PF3D7_1423600
uniprot id: Q8ILL6
names: Similarity
messages: Belongs to the protein kinase superfamily.

36329:PF3D7 0827900
gene id: 36329:PF3D7_0827900
uniprot id: C0H4Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

36329:PF3D7 0517400
gene id: 36329:PF3D7_0517400
uniprot id: Q8I3T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

36329:PF3D7 0810300
gene id: 36329:PF3D7_0810300
uniprot id: C0H4T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Enzyme with a broad specificity.
messages: Membrane

36329:PF3D7 0508000
gene id: 36329:PF3D7_0508000
uniprot id: Q8I423
names: Developmental Stage
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell surface
messages: Localizes to the merozoite surface. Mostly concentrated in secretory organelles at the apical end of the parasite, exclusively at an early stage of schizont development. Probably localizes in the rhoptry organelles.

36329:PF3D7 1223400
gene id: 36329:PF3D7_1223400
uniprot id: Q8I5I3
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1465800
gene id: 36329:PF3D7_1465800
uniprot id: Q8IKH9
names: Similarity
messages: Belongs to the dynein heavy chain family.

36329:PF3D7 1440800
gene id: 36329:PF3D7_1440800
uniprot id: Q8IL62
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1446200
gene id: 36329:PF3D7_1446200
uniprot id: Q8IL11
names: Similarity
messages: Belongs to the peptidase M17 family.

36329:PF3D7 0711000
gene id: 36329:PF3D7_0711000
uniprot id: P46468
names: Similarity
messages: Belongs to the AAA ATPase family.

36329:PF3D7 0316300.1
gene id: 36329:PF3D7_0316300.1
uniprot id: C0H477
uniprot id: O77392
names: Similarity
messages: Belongs to the PPase family.

36329:PF3D7 0214100
gene id: 36329:PF3D7_0214100
uniprot id: O96221
names: Similarity
messages: Belongs to the WD repeat SEC31 family.

36329:PF3D7 1009200
gene id: 36329:PF3D7_1009200
uniprot id: Q8IJV3
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1213500
gene id: 36329:PF3D7_1213500
uniprot id: Q8I5S0
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0822000
gene id: 36329:PF3D7_0822000
uniprot id: Q8IB54
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

36329:PF3D7 0722600
gene id: 36329:PF3D7_0722600
uniprot id: Q8IBM7
names: Subcellular Location Annotation
messages: nucleolus

36329:PF3D7 0923700
gene id: 36329:PF3D7_0923700
uniprot id: C0H554
names: Similarity
messages: Belongs to the CFAP298 family.

36329:PF3D7 1364800
gene id: 36329:PF3D7_1364800
uniprot id: Q8ID59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

36329:PF3D7 0303300
gene id: 36329:PF3D7_0303300
uniprot id: O77315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Nucleus

36329:PF3D7 1302800
gene id: 36329:PF3D7_1302800
uniprot id: Q8IET7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

36329:PF3D7 1311500
gene id: 36329:PF3D7_1311500
uniprot id: Q8IEK3
names: Similarity
messages: Belongs to the AAA ATPase family.

36329:PF3D7 0409900
gene id: 36329:PF3D7_0409900
uniprot id: Q8I1V9
names: Similarity
messages: Belongs to the actin family.

36329:PF3D7 1237000
gene id: 36329:PF3D7_1237000
uniprot id: Q8I553
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer.

36329:PF3D7 0503000
gene id: 36329:PF3D7_0503000
uniprot id: C0H4C3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

36329:PF3D7 1365900
gene id: 36329:PF3D7_1365900
uniprot id: Q8ID50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

36329:PF3D7 0605000
gene id: 36329:PF3D7_0605000
uniprot id: C6KSP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

36329:PF3D7 1301700
gene id: 36329:PF3D7_1301700
uniprot id: Q8IEJ0
names: Biotechnology
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: At the asexual blood stage, causes Maurer's cleft swelling and fragmentation, aberrant knob formation, with fewer and enlarged knobs, defective PfEMP1 trafficking characterized by impaired EMP1 surface expression and EMP1 accumulation at Maurer's clefts and a loss of adhesion of host infected erythrocytes to endothelial cell ligands (PubMed:32184257). Infected erythrocytes have decreased cellular rigidity and increased osmotic fragility (PubMed:32184257). Parasite growth is faster (PubMed:32184257).
messages: During the asexual blood stage and probably at the ring/trophozoite stages, plays a role in Maurer's cleft formation and/or morphology (PubMed:32184257). Also, involved in the loading of the virulence factor EMP1 into the Maurer's cleft membrane (PubMed:32184257). By binding to host chemokine CX3CL1, mediates the cytoadherence of host erythrocytes infected with parasite mature forms (late trophozoite and schizont) to endothelial cells, which sequesters them away from the circulation and thus prevents their elimination by the host spleen (PubMed:27653778).
messages: Expressed during the asexual blood stage in late rings, trophozoites and schizonts (at protein level) (PubMed:27653778, PubMed:24983235, PubMed:32184257). Expressed in gametocytes (at protein level) (PubMed:27653778).
messages: Host cell membrane
messages: Monomer (PubMed:27653778, PubMed:31356937). May form (via the first cytoplasmic domain) homodimers or homotrimers; disulfide-linked (PubMed:27653778, PubMed:31356937). Interacts with MAHRP1 (PubMed:32184257). May interact (via first cytoplasmic domain) with SBP1; the interaction is likely to occur at the ring stage in the Maurer's clefts and is weaken by ATP (PubMed:31356937). Interacts (via extracellular domain) with human chemokine CX3CL1; the interaction mediates the adhesion of infected erythrocytes with endothelial cells (PubMed:27653778).
messages: Potential vaccine candidate as CBP2-based peptides or antibodies against CBP2 prevent adhesion of infected erythrocytes to endothelial cells.
messages: The P.falciparum Export Element (PEXEL) motif, also known as the vacuolar transport signal (VTS), is a pentameric sequence (RxLxE/Q/D) required for the translocation of proteins across the parasitophorous vacuole membrane (Probable). In the endoplasmic reticulum, the motif is cleaved after the leucine residue and the N-terminus is N-acetylated (By similarity).
messages: The first cytoplasmic domain binds ATP and nucleic acids such as RNA and DNA in vitro.

36329:PF3D7 0503800
gene id: 36329:PF3D7_0503800
uniprot id: Q8I463
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

36329:PF3D7 0215800
gene id: 36329:PF3D7_0215800
uniprot id: O96237
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC5 family.
messages: Component of the origin recognition complex (ORC) (By similarity). Interacts with PCNA1; the interaction occurs during the trophozoite stage but not at the late schizont stage (PubMed:18554328).
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Expressed during the asexual blood stage, specifically during the trophozoite and schizont stages (at protein level).
messages: Nucleus

36329:PF3D7 1115300
gene id: 36329:PF3D7_1115300
uniprot id: Q8I6U5
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 0517700
gene id: 36329:PF3D7_0517700
uniprot id: Q8I3T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

36329:PF3D7 0315500
gene id: 36329:PF3D7_0315500
uniprot id: O97270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

36329:PF3D7 0705900
gene id: 36329:PF3D7_0705900
uniprot id: C0H4L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

36329:PF3D7 0319400
gene id: 36329:PF3D7_0319400
uniprot id: O97277
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

36329:PF3D7 0905200
gene id: 36329:PF3D7_0905200
uniprot id: Q8I397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 0605900
gene id: 36329:PF3D7_0605900
uniprot id: C6KSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

36329:PF3D7 0530200
gene id: 36329:PF3D7_0530200
uniprot id: Q8I0U9
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1325000
gene id: 36329:PF3D7_1325000
uniprot id: Q8IE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

36329:PF3D7 1421900
gene id: 36329:PF3D7_1421900
uniprot id: Q8ILN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

36329:PF3D7 0927600
gene id: 36329:PF3D7_0927600
uniprot id: Q8I2N3
names: Similarity
messages: Belongs to the SLBP family.

36329:PF3D7 1019400
gene id: 36329:PF3D7_1019400
uniprot id: Q8IJK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

36329:PF3D7 0404700
gene id: 36329:PF3D7_0404700
uniprot id: Q8I1Y2
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

36329:PF3D7 0710600
gene id: 36329:PF3D7_0710600
uniprot id: Q8IBY4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

36329:PF3D7 1107800
gene id: 36329:PF3D7_1107800
uniprot id: Q8IIS4
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1356300
gene id: 36329:PF3D7_1356300
uniprot id: Q8IDD9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 1212800
gene id: 36329:PF3D7_1212800
uniprot id: Q8I5S5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

36329:PF3D7 1205100
gene id: 36329:PF3D7_1205100
uniprot id: Q8I5Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

36329:PF3D7 0322900
gene id: 36329:PF3D7_0322900
uniprot id: O97313
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).
messages: Component of the small ribosomal subunit (PubMed:24913268, PubMed:26432834). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).
messages: Cytoplasm
messages: Expressed during the asexual blood stage (at protein level).

36329:PF3D7 1443300
gene id: 36329:PF3D7_1443300
uniprot id: Q8IL38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

36329:PF3D7 0925600
gene id: 36329:PF3D7_0925600
uniprot id: Q8I2Q2
names: Similarity
messages: Belongs to the yippee family.

36329:PF3D7 0607300
gene id: 36329:PF3D7_0607300
uniprot id: C6KSS1
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

36329:PF3D7 1203200
gene id: 36329:PF3D7_1203200
uniprot id: Q8I613
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

36329:PF3D7 0511000
gene id: 36329:PF3D7_0511000
uniprot id: Q8I3Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Involved in calcium binding and microtubule stabilization.

36329:PF3D7 1357300
gene id: 36329:PF3D7_1357300
uniprot id: Q8IDD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

36329:PF3D7 1230700
gene id: 36329:PF3D7_1230700
uniprot id: Q8I5B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: nuclear pore complex

36329:PF3D7 0303000
gene id: 36329:PF3D7_0303000
uniprot id: O77313
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

36329:PF3D7 1221600
gene id: 36329:PF3D7_1221600
uniprot id: Q8I5J7
names: Similarity
messages: Belongs to the WD repeat EIPR1 family.

36329:PF3D7 0803700
gene id: 36329:PF3D7_0803700
uniprot id: Q8IAN7
names: Function
names: Similarity
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.

36329:PF3D7 0605800
gene id: 36329:PF3D7_0605800
uniprot id: C6KSQ6
names: Biotechnology
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity (By similarity).
messages: Nucleus
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: Probable component of the MRN complex with MRE11.
messages: The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11 homodimer (By similarity).
messages: telomere

36329:PF3D7 1451800
gene id: 36329:PF3D7_1451800
uniprot id: Q8IKV8
names: Similarity
messages: Belongs to the VPS10-related sortilin family.

36329:PF3D7 0321900
gene id: 36329:PF3D7_0321900
uniprot id: C0H483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

36329:PF3D7 1003800
gene id: 36329:PF3D7_1003800
uniprot id: Q8IJZ9
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

36329:PF3D7 1465100
gene id: 36329:PF3D7_1465100
uniprot id: Q8IKI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

36329:PF3D7 1452300
gene id: 36329:PF3D7_1452300
uniprot id: Q8IKV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

36329:PF3D7 0928900
gene id: 36329:PF3D7_0928900
uniprot id: Q8I2M1
names: Similarity
messages: Belongs to the guanylate kinase family.

36329:PF3D7 0312400
gene id: 36329:PF3D7_0312400
uniprot id: O77344
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

36329:PF3D7 0913200
gene id: 36329:PF3D7_0913200
uniprot id: Q8I320
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

36329:PF3D7 0305500
gene id: 36329:PF3D7_0305500
uniprot id: O97239
names: Biotechnology
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dopey family.
messages: Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.
messages: May be involved in protein traffic between late Golgi and early endosomes.
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1475700
gene id: 36329:PF3D7_1475700
uniprot id: Q8IK81
names: Similarity
messages: Belongs to the tubulin family.

36329:PF3D7 0216600
gene id: 36329:PF3D7_0216600
uniprot id: O96245
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Membrane

36329:PF3D7 1106100
gene id: 36329:PF3D7_1106100
uniprot id: Q8IIU2
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

36329:PF3D7 0613800
gene id: 36329:PF3D7_0613800
uniprot id: C6KSY0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0914600
gene id: 36329:PF3D7_0914600
uniprot id: Q8I306
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

36329:PF3D7 1333300
gene id: 36329:PF3D7_1333300
uniprot id: Q8IDZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

36329:PF3D7 0323400
gene id: 36329:PF3D7_0323400
uniprot id: O97302
names: Biotechnology
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of the PfRH5 adhesion complex composed of 1 copy of CyRPA, RH5 and RIPR; the complex is formed during merozoite invasion of host erythrocytes specifically at the interface between the parasite and host membranes (PubMed:21909261, PubMed:25583518, PubMed:27374406, PubMed:28186186, PubMed:30542156). Within the complex, interacts with CyRPA (PubMed:28186186, PubMed:30542156). CyRPA recruitment of RIPR to RH5-P113-BSG leads to the formation of the PfRH5 adhesion complex which probably in turn releases RH5 from P113 while maintaining the interaction of the PfRH5 adhesion complex with BSG (PubMed:28186186).
messages: Conditional knockdown causes loss of cell growth and severely impairs merozoite invasion of erythrocytes. Attachment to and deformation of erythrocyte membrane is normal, however the subsequent step, which triggers an increase in Ca(2+) from the attached merozoite into the erythrocyte, is impaired.
messages: Contains disulfide bonds.
messages: Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:21909261, PubMed:25583518, PubMed:27374406, PubMed:27692771). As part of the PfRH5 adhesion complex, facilitates the interaction of RH5 and human BSG required for the Ca(2+) release into the erythrocyte (PubMed:27374406).
messages: Expressed in late throphozoide to schizonts and in merozoites (at protein level).
messages: Host cell membrane
messages: Potential candidate for the development of parasite blood stage vaccines. In vitro and in vivo, induces neutralizing antibodies capable of inhibiting merozoite invasion of host erythrocytes.
messages: Proteolytically cleaved into two chains of 125kDa and 65kDa which remain associated. The cleavage occurs at the schizont stage prior to the release of merozoites.
messages: Secreted
messages: microneme lumen

36329:PF3D7 1332900
gene id: 36329:PF3D7_1332900
uniprot id: Q8IDZ9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 1233000
gene id: 36329:PF3D7_1233000
uniprot id: Q8I592
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

36329:PF3D7 1005000
gene id: 36329:PF3D7_1005000
uniprot id: Q8I716
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 1421200
gene id: 36329:PF3D7_1421200
uniprot id: Q8ILN8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

36329:PF3D7 1325200
gene id: 36329:PF3D7_1325200
uniprot id: Q8IE66
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

36329:PF3D7 1304100
gene id: 36329:PF3D7_1304100
uniprot id: Q8IES4
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

36329:PF3D7 0626800
gene id: 36329:PF3D7_0626800
uniprot id: C6KTA4
names: Similarity
messages: Belongs to the pyruvate kinase family.

36329:PF3D7 1465500
gene id: 36329:PF3D7_1465500
uniprot id: Q8IKI3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

36329:PF3D7 0522500
gene id: 36329:PF3D7_0522500
uniprot id: C0H4F9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

36329:PF3D7 0505200
gene id: 36329:PF3D7_0505200
uniprot id: Q8I450
names: Similarity
messages: Belongs to the actin family.

36329:PF3D7 1244700
gene id: 36329:PF3D7_1244700
uniprot id: Q8I4Y4
names: Similarity
messages: Belongs to the FAM133 family.

36329:PF3D7 0720800
gene id: 36329:PF3D7_0720800
uniprot id: Q8IBP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

36329:PF3D7 1138100
gene id: 36329:PF3D7_1138100
uniprot id: Q8IHY3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.
messages: Cytoplasm

36329:PF3D7 0528200
gene id: 36329:PF3D7_0528200
uniprot id: Q8I3I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

36329:PF3D7 1359300
gene id: 36329:PF3D7_1359300
uniprot id: Q8IDB6
names: Similarity
messages: Belongs to the RNR ribonuclease family.

36329:PF3D7 1433600
gene id: 36329:PF3D7_1433600
uniprot id: Q8ILC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1132700
gene id: 36329:PF3D7_1132700
uniprot id: Q8II37
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

36329:PF3D7 1420900
gene id: 36329:PF3D7_1420900
uniprot id: Q8ILP1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

36329:PF3D7 0614400
gene id: 36329:PF3D7_0614400
uniprot id: C6KSY5
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1212700
gene id: 36329:PF3D7_1212700
uniprot id: Q8I5S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

36329:PF3D7 1428800.1
gene id: 36329:PF3D7_1428800.1
uniprot id: Q8ILH6
names: Similarity
messages: Belongs to the TBP family.

36329:PF3D7 0710400
gene id: 36329:PF3D7_0710400
uniprot id: A0A143ZWE7
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0517600
gene id: 36329:PF3D7_0517600
uniprot id: Q8I3T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

36329:PF3D7 0825600
gene id: 36329:PF3D7_0825600
uniprot id: Q8IB89
names: Similarity
messages: Belongs to the PET191 family.

36329:PF3D7 0703200
gene id: 36329:PF3D7_0703200
uniprot id: Q8IC38
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0305200
gene id: 36329:PF3D7_0305200
uniprot id: O97237
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1105000
gene id: 36329:PF3D7_1105000
uniprot id: Q8IIV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

36329:PF3D7 1411200
gene id: 36329:PF3D7_1411200
uniprot id: Q8ILY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

36329:PF3D7 1450100
gene id: 36329:PF3D7_1450100
uniprot id: Q8IKX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits.

36329:PF3D7 1337000
gene id: 36329:PF3D7_1337000
uniprot id: A0A5K1K885
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

36329:PF3D7 1442500
gene id: 36329:PF3D7_1442500
uniprot id: Q8IL46
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

36329:PF3D7 1403100
gene id: 36329:PF3D7_1403100
uniprot id: C6S3H2
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1114100.1
gene id: 36329:PF3D7_1114100.1
uniprot id: Q8IIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

36329:PF3D7 1117100
gene id: 36329:PF3D7_1117100
uniprot id: Q8IIJ6
names: Developmental Stage
names: Domain
names: Function
names: Similarity
messages: Belongs to the peptidase C12 family.
messages: Expressed during the parasite blood stage, in schizonts (at protein level).
messages: The Asn-rich domain is dispensable for deubiquitinating and deneddylating activities.
messages: Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8.

36329:PF3D7 1130200
gene id: 36329:PF3D7_1130200
uniprot id: Q8II61
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

36329:PF3D7 0218700
gene id: 36329:PF3D7_0218700
uniprot id: O96267
names: Similarity
messages: Belongs to the SNW family.

36329:PF3D7 1459700
gene id: 36329:PF3D7_1459700
uniprot id: Q8IKN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

36329:PF3D7 1215200
gene id: 36329:PF3D7_1215200
uniprot id: Q8I5Q4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

36329:PF3D7 1358800
gene id: 36329:PF3D7_1358800
uniprot id: Q8IDB0
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

36329:PF3D7 1337100
gene id: 36329:PF3D7_1337100
uniprot id: Q8IDW1
names: Similarity
messages: Belongs to the protein kinase superfamily.

36329:PF3D7 1030600
gene id: 36329:PF3D7_1030600
uniprot id: Q8IJ99
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Component of the EKC/KEOPS complex; the whole complex dimerizes.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

36329:PF3D7 0820700
gene id: 36329:PF3D7_0820700
uniprot id: Q8I6S5
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

36329:PF3D7 0721900
gene id: 36329:PF3D7_0721900
uniprot id: C0H4P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

36329:PF3D7 1408100
gene id: 36329:PF3D7_1408100
uniprot id: Q8IM15
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Dimerization causes loss of catalytic activity (PubMed:20435072). Inhibited by pepstatin A (PubMed:16624575). Inhibited by Zn(2+) (PubMed:20435072).
messages: During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) or globins (PubMed:16624575). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).
messages: Expressed during the asexual blood stage; expression begins in trophozoites and continues in schizonts (at protein level).
messages: It is unclear if PMIII is glycosylated as other members of the same enzyme family, ie. PMI and PMII, are not.
messages: Membrane
messages: No growth defect (PubMed:15513918). However, slight decrease in proliferation and slight increase in doubling time during the asexual blood stage in an amino acid-limited medium (PubMed:15513918). Triple knockout of PMI, PMII and PMIII causes a slight decrease in proliferation during the asexual blood stage in an amino acid-limited medium (PubMed:17581121). Quadruple knockout of PMI, PMII, PMIII and PMIV causes a decrease in proliferation, an impaired proliferation in an amino acid-limited medium, a reduced formation of haemozoin and an abnormal accumulation of endosomal vesicles inside the digestive vacuole (PubMed:17581121).
messages: Probable homodimer; in the zymogen form (Probable). Monomer; in the active form (PubMed:20435072). Acidification disrupts homodimerization (By similarity). Component of the hemozoin formation complex (HFC) composed of falcipain 2, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN (PubMed:23471987). The HFC complex is involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage (PubMed:23471987).
messages: Proteolytically cleaved into the soluble active mature form by cysteine proteases in the digestive vacuole of trophozoites (By similarity). Proteolysis requires an acidic environment (By similarity). Transprocessing may serve as an alternate activation system (PubMed:18312598).
messages: Unlike other plasmepsins, one of the two catalytic aspartates, Asp-157, is replaced with histidine; however, the protein is catalytic active (PubMed:16624575). Unlikely to act as a serine protease (PubMed:18312598). His-157 may stabilizes the catalysis and Asp-337 may act as both an acid and a base during catalysis.
messages: Vacuole lumen

36329:PF3D7 1306800
gene id: 36329:PF3D7_1306800
uniprot id: Q8IEP7
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0528400
gene id: 36329:PF3D7_0528400
uniprot id: Q8I3I3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

36329:PF3D7 1212000
gene id: 36329:PF3D7_1212000
uniprot id: Q8I5T2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

36329:PF3D7 1417500
gene id: 36329:PF3D7_1417500
uniprot id: Q8ILS0
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

36329:PF3D7 1116500
gene id: 36329:PF3D7_1116500
uniprot id: Q8IIK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

36329:PF3D7 0503600
gene id: 36329:PF3D7_0503600
uniprot id: Q8I465
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

36329:PF3D7 1228600
gene id: 36329:PF3D7_1228600
uniprot id: Q8I5D2
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A truncated form of MSP9 has serine protease activity in vitro; however, it is not clear if this is physiologically relevant (PubMed:10699251). Also, the putative residues forming the catalytic triad (His-55, Asp-94, and Ser-190) are not conserved in P.vivax, P.knowlesi, and P.cynomolgi orthologs casting a doubt on the physiological relevance of the protease activity (PubMed:14630931).
messages: Belongs to the plasmodium ABRA family.
messages: Cell membrane
messages: During the asexual blood stage, involved in the sialic acid-independent (SAID) merozoite invasion of host erythrocytes by binding to host SLC4A1/Band 3 protein on the surface of the host erythrocyte.
messages: Expressed during the asexual blood stage, including in merozoites (at protein level).
messages: Interacts with MSP1 19kDa (MSP1p19) and 42kDa (MSP1p42) proteolytic products; the interaction is direct (PubMed:14630931, PubMed:16289042). Interacts with host SLC4A1/Band 3 protein (via the 5ABC region) (PubMed:14630931). MSP1p19 or MSP1p42 and MSP9 form a co-ligand complex that interacts with host SLC4A1/Band 3 protein (PubMed:14630931, PubMed:16289042).
messages: Not glycosylated.
messages: Parasitophorous vacuole lumen
messages: Secreted

36329:PF3D7 1466400
gene id: 36329:PF3D7_1466400
uniprot id: Q8IKH2
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0610800
gene id: 36329:PF3D7_0610800
uniprot id: C6KSV3
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Homodimer.

36329:PF3D7 1460800
gene id: 36329:PF3D7_1460800
uniprot id: Q8IKM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus

36329:PF3D7 0314300
gene id: 36329:PF3D7_0314300
uniprot id: O97275
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

36329:PF3D7 1025600
gene id: 36329:PF3D7_1025600
uniprot id: Q8IJE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

36329:PF3D7 1217300
gene id: 36329:PF3D7_1217300
uniprot id: A0A144A297
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.

36329:PF3D7 1226800
gene id: 36329:PF3D7_1226800
uniprot id: Q8I5F0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1117500
gene id: 36329:PF3D7_1117500
uniprot id: Q8IIJ2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 0826500
gene id: 36329:PF3D7_0826500
uniprot id: C0H4Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

36329:PF3D7 0707900
gene id: 36329:PF3D7_0707900
uniprot id: Q8IC10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

36329:PF3D7 1459800
gene id: 36329:PF3D7_1459800
uniprot id: Q8IKN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

36329:PF3D7 1118100
gene id: 36329:PF3D7_1118100
uniprot id: Q8III7
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

36329:PF3D7 1128100
gene id: 36329:PF3D7_1128100
uniprot id: Q8II82
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

36329:PF3D7 1012300
gene id: 36329:PF3D7_1012300
uniprot id: Q8IJS2
names: Similarity
messages: Belongs to the UQCRB/QCR7 family.

36329:PF3D7 0612700
gene id: 36329:PF3D7_0612700
uniprot id: C6KSX0
names: Developmental Stage
names: Disruption Phenotype
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell surface
messages: Does not have erythrocyte-receptor-binding ability.
messages: Heterodimer; heterodimerizes with PF41. May form an antiparallel heterodimer with PF41.
messages: No visible phenotype. Parasites grow at normal rates in vitro.
messages: Processed into a soluble form.
messages: Specifically present in asexual blood stage parasites. First detected in the trophozoite stage, 30-40 hours post-invasion (HPI) and the proteins reaches peak expression in schizont stage, 40-48 HPI.

36329:PF3D7 0527000
gene id: 36329:PF3D7_0527000
uniprot id: Q8I3J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

36329:PF3D7 1117700
gene id: 36329:PF3D7_1117700
uniprot id: Q7KQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

36329:PF3D7 1454700
gene id: 36329:PF3D7_1454700
uniprot id: Q8IKT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

36329:PF3D7 0214400
gene id: 36329:PF3D7_0214400
uniprot id: O96224
names: Similarity
messages: Belongs to the LTV1 family.

36329:PF3D7 0111500
gene id: 36329:PF3D7_0111500
uniprot id: Q8I231
names: Similarity
messages: Belongs to the adenylate kinase family.

36329:PF3D7 1353900
gene id: 36329:PF3D7_1353900
uniprot id: Q8IDG2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

36329:PF3D7 1428700
gene id: 36329:PF3D7_1428700
uniprot id: Q8ILH7
names: Similarity
messages: Belongs to the cytochrome b5 family.

36329:PF3D7 1239700
gene id: 36329:PF3D7_1239700
uniprot id: Q8I526
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

36329:PF3D7 0211600
gene id: 36329:PF3D7_0211600
uniprot id: O96196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

36329:PF3D7 1119600
gene id: 36329:PF3D7_1119600
uniprot id: Q8IIH1
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

36329:PF3D7 1037700
gene id: 36329:PF3D7_1037700
uniprot id: Q8IJ30
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

36329:PF3D7 0211400
gene id: 36329:PF3D7_0211400
uniprot id: Q7KWI9
names: Similarity
messages: Belongs to the thiolase-like superfamily. FabH family.

36329:PF3D7 1416200
gene id: 36329:PF3D7_1416200
uniprot id: Q8ILT4
names: Caution
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the peptidase C14B family.
messages: Expressed during all parasite blood stages (at protein level).
messages: In contrast to other metacaspases of the peptidase C14B family, the catalytic histidine and cysteine residues do not appear to be conserved. Contains a serine residue at the position of the canonical catalytic cysteine which may constitute the active site.
messages: Protease that cleaves specifically after arginine or lysine residues.

36329:PF3D7 0817500
gene id: 36329:PF3D7_0817500
uniprot id: Q7K6B1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0825200
gene id: 36329:PF3D7_0825200
uniprot id: Q8IB86
names: Similarity
messages: Belongs to the IF-3 family.

36329:PF3D7 1437200
gene id: 36329:PF3D7_1437200
uniprot id: Q8IL94
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

36329:PF3D7 1216000
gene id: 36329:PF3D7_1216000
uniprot id: Q8I5P7
names: Biotechnology
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer (By similarity).
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0511800
gene id: 36329:PF3D7_0511800
uniprot id: Q8I3Y8
names: Function
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.
messages: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (By similarity). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). De novo-synthesized myo-inositol is essential for incorporation into GPI (glycosylphosphatidylinositol) glycolipids during intra-erythrocytic development (PubMed:24350823).

36329:PF3D7 1116700
gene id: 36329:PF3D7_1116700
uniprot id: Q8IIJ9
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Binds 1 Cl(-) ion per heavy chain.
messages: Expressed during the asexual blood stage including in trophozoites and schizonts (at protein level).
messages: Monomer.
messages: Parasitophorous vacuole lumen
messages: Thiol protease that cleaves dipeptides from the N-terminus of protein substrates (PubMed:15304495, PubMed:20833209). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:20833209). Proline cannot occupy the P1 position and arginine or lysine cannot occupy the P2 position of the substrate (PubMed:20833209). Involved in host hemoglobin degradation by generating dipeptides from hemoglobin-derived oligopeptides (PubMed:15304495).
messages: Vacuole lumen

36329:PF3D7 0303400
gene id: 36329:PF3D7_0303400
uniprot id: O97224
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

36329:PF3D7 1469400
gene id: 36329:PF3D7_1469400
uniprot id: Q8IKE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

36329:PF3D7 0617900
gene id: 36329:PF3D7_0617900
uniprot id: C6KT19
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

36329:PF3D7 1230800
gene id: 36329:PF3D7_1230800
uniprot id: Q8I5B2
names: Similarity
messages: Belongs to the fl(2)d family.

36329:PF3D7 1354800
gene id: 36329:PF3D7_1354800
uniprot id: Q8IDF3
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by Ca(2+).
messages: Belongs to the peptidase C14B family.
messages: Cysteine protease that cleaves specifically after arginine or lysine residues (PubMed:21858231). May play a role in apoptosis (PubMed:21858231).
messages: Monomer.

36329:PF3D7 1360200
gene id: 36329:PF3D7_1360200
uniprot id: Q8IDA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Membrane

36329:PF3D7 1247400
gene id: 36329:PF3D7_1247400
uniprot id: Q8I4V8
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FKBP-type PPIase family.
messages: Cytoplasm
messages: Expressed during all parasite blood stages (at protein level).
messages: Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147).
messages: Homodimer (PubMed:17289400). Interacts (via TPR repeats) with HSP90 (probably via MEEVD motif) (PubMed:15850699, PubMed:19691130).
messages: Inhibited by FK506 and its derivates, such as ascomycin, and rapamycin (PubMed:15664653, PubMed:15850699). FK506 and rapamycin inhibit peptidylprolyl isomerase activity but not chaperone activity (PubMed:15664653). Inhibited by N-(2-ethyl-phenyl)-2-(3H-imidazao [4, 5-b] pyridin-2-yl-sulfanyl)-acetamide (D44) (PubMed:23974147). Not inhibited by cyclosporin A (PubMed:15664653, PubMed:15850699). Inhibition of calcineurin phosphatase activity is enhanced by FK506 (PubMed:15850699).
messages: Nucleus
messages: The PPIase FKBP-type domain contributes to the chaperone activity (PubMed:15664653). Required for the inhibition of calcineurin phosphatase activity (PubMed:15850699).
messages: The TPR repeats are important for the chaperone activity (PubMed:15664653). In another study, these repeats appear to be dispensable for chaperone activity (PubMed:15850699). Dispensable for PPIase activity (PubMed:15850699). Dispensable for the inhibition of calcineurin phosphatase activity (PubMed:15850699).

36329:PF3D7 1033100
gene id: 36329:PF3D7_1033100
uniprot id: Q8IJ77
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Belongs to the eukaryotic AdoMetDC family.

36329:PF3D7 0920200
gene id: 36329:PF3D7_0920200
uniprot id: Q8I2V1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 0312500
gene id: 36329:PF3D7_0312500
uniprot id: O77343
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1311400
gene id: 36329:PF3D7_1311400
uniprot id: Q8IEK4
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

36329:PF3D7 1324700
gene id: 36329:PF3D7_1324700
uniprot id: C0H5D3
names: Similarity
messages: Belongs to the synaptobrevin family.

36329:PF3D7 0814900
gene id: 36329:PF3D7_0814900
uniprot id: Q8IAY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

36329:PF3D7 1116200.1
gene id: 36329:PF3D7_1116200.1
uniprot id: Q8IIK4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of Pdx1.
messages: Cytoplasm
messages: Expressed throughout development. Highest expression in segmenters stage followed by schizonts stage.
messages: In the presence of Pdx1, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

36329:PF3D7 0806800
gene id: 36329:PF3D7_0806800
uniprot id: Q8IAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

36329:PF3D7 1469300
gene id: 36329:PF3D7_1469300
uniprot id: Q8IKE4
names: Similarity
messages: Belongs to the PNO1 family.

36329:PF3D7 0904700
gene id: 36329:PF3D7_0904700
uniprot id: Q8I3A2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

36329:PF3D7 1127100
gene id: 36329:PF3D7_1127100
uniprot id: Q8II92
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

36329:PF3D7 0219600
gene id: 36329:PF3D7_0219600
uniprot id: O96271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

36329:PF3D7 0621900
gene id: 36329:PF3D7_0621900
uniprot id: C6KT56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Cytoplasm
messages: nucleolus

36329:PF3D7 0507100
gene id: 36329:PF3D7_0507100
uniprot id: Q8I431
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

36329:PF3D7 0727400
gene id: 36329:PF3D7_0727400
uniprot id: Q8IBI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

36329:PF3D7 1224400
gene id: 36329:PF3D7_1224400
uniprot id: Q8I5H3
names: Subcellular Location Annotation
messages: nucleolus

36329:PF3D7 1329200
gene id: 36329:PF3D7_1329200
uniprot id: Q8IE51
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0822600
gene id: 36329:PF3D7_0822600
uniprot id: Q8IB60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1209400
gene id: 36329:PF3D7_1209400
uniprot id: Q8I5V5
names: Function
names: Similarity
messages: Belongs to the WD repeat CIA1 family.
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.

36329:PF3D7 1429500
gene id: 36329:PF3D7_1429500
uniprot id: Q8ILG9
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.

36329:PF3D7 1103600
gene id: 36329:PF3D7_1103600
uniprot id: Q8IIW6
names: Similarity
messages: Belongs to the actin family.

36329:PF3D7 1406700
gene id: 36329:PF3D7_1406700
uniprot id: Q8IM27
names: Similarity
messages: Belongs to the VPS29 family.

36329:PF3D7 1210900
gene id: 36329:PF3D7_1210900
uniprot id: Q8I5U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

36329:PF3D7 1311200
gene id: 36329:PF3D7_1311200
uniprot id: Q8IEK5
names: Similarity
messages: Belongs to the WD repeat SMU1 family.

36329:PF3D7 1441800
gene id: 36329:PF3D7_1441800
uniprot id: Q8IL52
names: Biotechnology
names: Similarity
messages: Belongs to the SNF7 family.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1430300
gene id: 36329:PF3D7_1430300
uniprot id: Q8ILG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: cytosol

36329:PF3D7 1441700
gene id: 36329:PF3D7_1441700
uniprot id: Q8IL53
names: Similarity
messages: Belongs to the peptidase M76 family.

36329:PF3D7 0824400
gene id: 36329:PF3D7_0824400
uniprot id: Q8IB78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

36329:PF3D7 1303200.1
gene id: 36329:PF3D7_1303200.1
uniprot id: Q8IET3
names: Similarity
messages: Belongs to the synaptobrevin family.

36329:PF3D7 0502800
gene id: 36329:PF3D7_0502800
uniprot id: Q8I473
names: Similarity
messages: Belongs to the DPH4 family.

36329:PF3D7 1122900
gene id: 36329:PF3D7_1122900
uniprot id: Q8IID4
names: Biotechnology
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
messages: Belongs to the dynein heavy chain family.
messages: Consists of at least two heavy chains and a number of intermediate and light chains.
messages: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: cytoskeleton

36329:PF3D7 0417500.1
gene id: 36329:PF3D7_0417500.1
uniprot id: C0H4B1
names: Similarity
messages: Belongs to the MEMO1 family.

36329:PF3D7 0109700
gene id: 36329:PF3D7_0109700
uniprot id: Q8I247
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

36329:PF3D7 0311600
gene id: 36329:PF3D7_0311600
uniprot id: O77351
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

36329:PF3D7 1245400
gene id: 36329:PF3D7_1245400
uniprot id: Q8I4X7
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

36329:PF3D7 1229400
gene id: 36329:PF3D7_1229400
uniprot id: Q8I5C5
names: Similarity
messages: Belongs to the MIF family.

36329:PF3D7 1341600
gene id: 36329:PF3D7_1341600
uniprot id: Q8IDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0521700
gene id: 36329:PF3D7_0521700
uniprot id: Q8I3P6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.

36329:PF3D7 0705400
gene id: 36329:PF3D7_0705400
uniprot id: Q8IC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

36329:PF3D7 1128400
gene id: 36329:PF3D7_1128400
uniprot id: Q8II79
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

36329:PF3D7 1467300
gene id: 36329:PF3D7_1467300
uniprot id: Q8IKG4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DXR family.
messages: Binds 1 divalent cation per subunit. Mg(2+) or Mn(2+).
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Homodimer.
messages: Inhibited by fosmidomycin and its derivatives.
messages: apicoplast

36329:PF3D7 0406200
gene id: 36329:PF3D7_0406200
uniprot id: Q6ZMA7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in gametocytes; expression starts in young gametocytes (30-40h post-invasion of host erythrocytes) (at protein level).
messages: Involved in male gametogenesis (PubMed:14698439). Required for exflagellation of male gametocytes (PubMed:14698439). May play a role in parasite transmission in the mosquito (By similarity). Binds to the mosquito vector midgut (By similarity).
messages: Parasitophorous vacuole membrane
messages: Vacuole

36329:PF3D7 1035200
gene id: 36329:PF3D7_1035200
uniprot id: Q03400
names: Function
names: Polymorphism
names: Subcellular Location Annotation
messages: Diversity in S-antigen is mainly due to polymorphism in the repetitive regions.
messages: Parasitophorous vacuole
messages: S antigens are soluble heat-stable proteins present in the sera of some infected individuals.

36329:PF3D7 0303500
gene id: 36329:PF3D7_0303500
uniprot id: O97225
names: Similarity
messages: Belongs to the TUBGCP family.

36329:PF3D7 0904500
gene id: 36329:PF3D7_0904500
uniprot id: Q8I3A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

36329:PF3D7 0810200
gene id: 36329:PF3D7_0810200
uniprot id: Q8IAT7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

36329:PF3D7 1461300
gene id: 36329:PF3D7_1461300
uniprot id: Q8IKL9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

36329:PF3D7 1017000
gene id: 36329:PF3D7_1017000
uniprot id: Q7KQL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

36329:PF3D7 0623900
gene id: 36329:PF3D7_0623900
uniprot id: C6KT75
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

36329:PF3D7 0406400
gene id: 36329:PF3D7_0406400
uniprot id: C0H490
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

36329:PF3D7 0916600
gene id: 36329:PF3D7_0916600
uniprot id: Q8I2Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

36329:PF3D7 0723000
gene id: 36329:PF3D7_0723000
uniprot id: Q8IBM3
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

36329:PF3D7 1205500
gene id: 36329:PF3D7_1205500
uniprot id: Q8I5Z0
names: Similarity
messages: Belongs to the CHFR family.

36329:PF3D7 1403000
gene id: 36329:PF3D7_1403000
uniprot id: Q8IM61
names: Similarity
messages: Belongs to the flagellar radial spoke RSP3 family.

36329:PF3D7 0729500
gene id: 36329:PF3D7_0729500
uniprot id: Q8I6Z2
names: Similarity
messages: Belongs to the MT-A70-like family.

36329:PF3D7 1429000
gene id: 36329:PF3D7_1429000
uniprot id: Q8ILH4
names: Similarity
messages: Belongs to the archease family.

36329:PF3D7 1406900
gene id: 36329:PF3D7_1406900
uniprot id: Q8IM25
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 0524600
gene id: 36329:PF3D7_0524600
uniprot id: Q8I3L9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

36329:PF3D7 1445300
gene id: 36329:PF3D7_1445300
uniprot id: Q8IL20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

36329:PF3D7 0628000
gene id: 36329:PF3D7_0628000
uniprot id: C6KTB6
names: Similarity
messages: Belongs to the PTPS family.

36329:PF3D7 0930900
gene id: 36329:PF3D7_0930900
uniprot id: C0H578
names: Similarity
messages: Belongs to the NifU family.

36329:PF3D7 1453800
gene id: 36329:PF3D7_1453800
uniprot id: Q8IKU0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Bifunctional enzyme which catalyzes the first two steps of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
messages: G6PD activity is inhibited by glucosamine-6-phosphate, NADPH, and 4-(4-bromophenyl)-7-(3,4-dimethoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1 H,3H)-dione. G6PD and 6PGL activities can be reversibly inhibited by S-glutathionylation (in vitro).
messages: Homotetramer.
messages: In the C-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.
messages: In the N-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

36329:PF3D7 1433500
gene id: 36329:PF3D7_1433500
uniprot id: Q8ILC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

36329:PF3D7 1032100
gene id: 36329:PF3D7_1032100
uniprot id: Q8IJ85
names: Similarity
messages: Belongs to the DCP1 family.

36329:PF3D7 1010600
gene id: 36329:PF3D7_1010600
uniprot id: Q8IJT9
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

36329:PF3D7 1236800
gene id: 36329:PF3D7_1236800
uniprot id: Q8I555
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1319300
gene id: 36329:PF3D7_1319300
uniprot id: Q8IEC3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

36329:PF3D7 0717500
gene id: 36329:PF3D7_0717500
uniprot id: Q8IBS5
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by calcium (PubMed:19307175, PubMed:19666141). Upon calcium binding to the EF-hand domains, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (PubMed:19307175). This, in turn, may facilitate the autophosphorylation of the activation loop at Thr-234, which leads to the kinase activation (PubMed:19307175). Intracellular calcium increase is triggered by xanthurenic acid (XA), a small mosquito molecule that induces the differentiation of specialized transmission stages, the gametocytes, into male and female gametes (Probable). Activated by a decrease in temperature (20 degrees Celsius) and an increase in pH (7.6) occurring when the parasite is ingested by in the mosquito (PubMed:19666141).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
messages: Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141). Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite. During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK5. Involved in merosome egress from host hepatocytes, probably together with CDPK5. During the asexual blood stage, involved in merozoite invasion of host erythrocytes and motility by stabilizing the inner membrane complex, a structure below the plasma membrane which acts as an anchor for the glidosome, an acto-myosin motor. Required for cell cycle progression in the male gametocyte. During male gametogenesis in the mosquito gut, required to initiate the first round of DNA replication, probably by facilitating the assembly of the pre-replicative MCM complex, to assemble the first mitotic spindle and, at the end of gametogenesis, to initiate axoneme motility, cytokinesis and subsequent exflagellation. For each of these steps, may phosphorylate SOC1, SOC2 and SOC3, respectively. Together with CDPK1, regulates ookinete gliding in the mosquito host midgut (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in gametocytes (at protein level).
messages: Induced by xanthurenic acid (XA) and human serum.
messages: May be autophosphorylated on Thr-234 in vitro.
messages: May interact with the pre-replication MCM complex prior male gametogenesis activation.
messages: Myristoylated; myristoylation may target it to different subcellular compartments. During male gametogenesis, myristoylation is required to initiate DNA replication but not for mitotic spindle assembly or axoneme activation.
messages: Not palmitoylated.
messages: Replication in host erythrocytes is normal.
messages: The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive (PubMed:19307175). The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains (PubMed:19307175).

36329:PF3D7 1236600
gene id: 36329:PF3D7_1236600
uniprot id: Q8I557
names: Similarity
messages: Belongs to the TPPP family.

36329:PF3D7 0728200
gene id: 36329:PF3D7_0728200
uniprot id: Q8IBH5
names: Similarity
messages: Belongs to the actin family.

36329:PF3D7 1123700
gene id: 36329:PF3D7_1123700
uniprot id: Q8IIC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

36329:PF3D7 1033600
gene id: 36329:PF3D7_1033600
uniprot id: Q7KQL1
names: Similarity
messages: Belongs to the CEF1 family.

36329:PF3D7 1146900
gene id: 36329:PF3D7_1146900
uniprot id: C6S3G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

36329:PF3D7 1458100
gene id: 36329:PF3D7_1458100
uniprot id: Q8IKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

36329:PF3D7 1111300
gene id: 36329:PF3D7_1111300
uniprot id: Q8IIP9
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1434100
gene id: 36329:PF3D7_1434100
uniprot id: Q8ILC2
names: Similarity
messages: Belongs to the queuine tRNA-ribosyltransferase family.

36329:PF3D7 0318300
gene id: 36329:PF3D7_0318300
uniprot id: O77374
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1317000
gene id: 36329:PF3D7_1317000
uniprot id: Q8I6Z8
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1429900
gene id: 36329:PF3D7_1429900
uniprot id: Q8ILG5
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

36329:PF3D7 0422100
gene id: 36329:PF3D7_0422100
uniprot id: Q8IFP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

36329:PF3D7 0803000
gene id: 36329:PF3D7_0803000
uniprot id: Q8IAN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYF2 family.
messages: Nucleus

36329:PF3D7 1213900
gene id: 36329:PF3D7_1213900
uniprot id: A0A144A0U7
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

36329:PF3D7 1214400
gene id: 36329:PF3D7_1214400
uniprot id: Q8I5R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0407900
gene id: 36329:PF3D7_0407900
uniprot id: Q9U0K7
names: Similarity
messages: Belongs to the AAA ATPase family.

36329:PF3D7 1108200
gene id: 36329:PF3D7_1108200
uniprot id: Q8IIS0
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids (PubMed:24302572, PubMed:27224426).
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: D-aminoacyl-tRNA deacylase, with no observable activity on tRNAs charged with their cognate L-amino acid (PubMed:20007323, PubMed:24302572, PubMed:27224426). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (PubMed:27224426). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (PubMed:20007323, PubMed:24302572, PubMed:27224426). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) (PubMed:27224426). Deacylates mischarged D.melanogaster and E.coli glycyl-tRNA(Ala) (PubMed:28362257). Probably acts via tRNA-based rather than protein-based catalysis (PubMed:24302572, PubMed:27224426). Acts on tRNAs only when the D-amino acid is either attached to the ribose 3'-OH or transferred to the 3'-OH from the 2'-OH through rapid transesterification (PubMed:24302572). Binds a number of other D-amino acids (D-Arg, D-Glu, D-His, D-Lys, D-Ser), suggesting it may also deacylate other mischarged tRNAs (PubMed:20007323).
messages: Homodimer (PubMed:20007323, PubMed:24302572).
messages: In the crystal structures with bound ADP (PDB 3KO4, 3KO5), the adenosine moiety is thought to represent the authentic C-terminal adenosine of charged tRNA and is annotated as such in this entry (PubMed:20007323).
messages: Initially the conserved reside Thr-90 was thought to be a nucleophile; mutagenesis in this organism and E.coli indicates it is not.

36329:PF3D7 1107200
gene id: 36329:PF3D7_1107200
uniprot id: Q8IIT1
names: Similarity
messages: Belongs to the CCZ1 family.

36329:PF3D7 0317700
gene id: 36329:PF3D7_0317700
uniprot id: O77380
names: Similarity
messages: Belongs to the DDB1 family.

36329:PF3D7 0703600
gene id: 36329:PF3D7_0703600
uniprot id: C0H4K2
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0725200
gene id: 36329:PF3D7_0725200
uniprot id: Q8IBJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

36329:PF3D7 0418200
gene id: 36329:PF3D7_0418200
uniprot id: Q8I1Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

36329:PF3D7 1463200
gene id: 36329:PF3D7_1463200
uniprot id: Q8IKK4
names: Similarity
messages: Belongs to the activator 1 small subunits family.

36329:PF3D7 0614300
gene id: 36329:PF3D7_0614300
uniprot id: C6KSY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

36329:PF3D7 0210000
gene id: 36329:PF3D7_0210000
uniprot id: O96183
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1365100
gene id: 36329:PF3D7_1365100
uniprot id: Q8ID56
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

36329:PF3D7 0903100
gene id: 36329:PF3D7_0903100
uniprot id: Q8I3B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

36329:PF3D7 1454500
gene id: 36329:PF3D7_1454500
uniprot id: Q8IKT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion matrix
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

36329:PF3D7 0807700
gene id: 36329:PF3D7_0807700
uniprot id: Q8IAR5
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1C family.
messages: By heat and oxidative stresses in trophozoites and schizonts (at protein level).
messages: Cytoplasm
messages: During the asexual blood stage, expressed in trophozoites, schizonts and free merozoites (at protein level).
messages: Host cell membrane
messages: Host cytoplasm
messages: Oligomer; may form trimers or hexamers (PubMed:24494818). Forms a complex at least composed of DegP, ENO and HSP70 (PubMed:24494818).
messages: Parasitophorous vacuole
messages: Serine protease which also acts as a protein chaperone (PubMed:24494818). Plays a role in the parasite development in host erythrocytes possibly by protecting it against thermal and oxidative stresses (PubMed:24494818).
messages: The PDZ domain is dispensable for protease and chaperone activities.

36329:PF3D7 1348200
gene id: 36329:PF3D7_1348200
uniprot id: Q8IDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

36329:PF3D7 0414000
gene id: 36329:PF3D7_0414000
uniprot id: Q8I1U7
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-101 by ESCO1 is important for genome stability and S phase sister chromatid cohesion.
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity).
messages: Component of the cohesin complex.
messages: Nucleus
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).

36329:PF3D7 1104700.1
gene id: 36329:PF3D7_1104700.1
uniprot id: Q8IIV5
names: Similarity
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.

36329:PF3D7 1246800
gene id: 36329:PF3D7_1246800
uniprot id: Q8I4W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0302000
gene id: 36329:PF3D7_0302000
uniprot id: O97334
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

36329:PF3D7 1115600
gene id: 36329:PF3D7_1115600
uniprot id: Q8IIK8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

36329:PF3D7 0810100
gene id: 36329:PF3D7_0810100
uniprot id: C0H4T5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

36329:PF3D7 0612300
gene id: 36329:PF3D7_0612300
uniprot id: C6KSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

36329:PF3D7 1430900
gene id: 36329:PF3D7_1430900
uniprot id: Q8I6V2
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 2 family.

36329:PF3D7 1366900
gene id: 36329:PF3D7_1366900
uniprot id: Q8ID39
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0611700
gene id: 36329:PF3D7_0611700
uniprot id: C0H4H3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

36329:PF3D7 0909800
gene id: 36329:PF3D7_0909800
uniprot id: C0H529
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

36329:PF3D7 1244200
gene id: 36329:PF3D7_1244200
uniprot id: Q8I4Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

36329:PF3D7 1472000
gene id: 36329:PF3D7_1472000
uniprot id: Q8IKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

36329:PF3D7 1037600
gene id: 36329:PF3D7_1037600
uniprot id: Q8IJ31
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

36329:PF3D7 1454600
gene id: 36329:PF3D7_1454600
uniprot id: Q8IKT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS11 family.
messages: chloroplast

36329:PF3D7 1350100
gene id: 36329:PF3D7_1350100
uniprot id: Q8IDJ8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

36329:PF3D7 0905300
gene id: 36329:PF3D7_0905300
uniprot id: Q8I396
names: Similarity
messages: Belongs to the dynein heavy chain family.

36329:PF3D7 0811000
gene id: 36329:PF3D7_0811000
uniprot id: Q8IAU5
names: Similarity
messages: Belongs to the cullin family.

36329:PF3D7 1412100
gene id: 36329:PF3D7_1412100
uniprot id: Q8ILX3
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1460300
gene id: 36329:PF3D7_1460300
uniprot id: C6S3J6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

36329:PF3D7 0934800
gene id: 36329:PF3D7_0934800
uniprot id: Q7K6A0
names: Similarity
messages: Belongs to the protein kinase superfamily.

36329:PF3D7 1338400
gene id: 36329:PF3D7_1338400
uniprot id: Q8IDU9
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1008800
gene id: 36329:PF3D7_1008800
uniprot id: Q8IJV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

36329:PF3D7 1414300
gene id: 36329:PF3D7_1414300
uniprot id: Q8ILV2
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

36329:PF3D7 0816500
gene id: 36329:PF3D7_0816500
uniprot id: Q8IB02
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

36329:PF3D7 1316100
gene id: 36329:PF3D7_1316100
uniprot id: Q8IEF3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

36329:PF3D7 0502000
gene id: 36329:PF3D7_0502000
uniprot id: Q8I480
names: Biotechnology
names: Subcellular Location Annotation
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1470000
gene id: 36329:PF3D7_1470000
uniprot id: C6S3K2
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.

36329:PF3D7 1246100
gene id: 36329:PF3D7_1246100
uniprot id: Q8I4X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm

36329:PF3D7 1418000
gene id: 36329:PF3D7_1418000
uniprot id: Q8ILR6
names: Similarity
messages: Belongs to the UFD1 family.

36329:PF3D7 1019900
gene id: 36329:PF3D7_1019900
uniprot id: Q8IJK2
names: Similarity
messages: Belongs to the ATG8 family.

36329:PF3D7 0319600
gene id: 36329:PF3D7_0319600
uniprot id: O97319
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

36329:PF3D7 1145400
gene id: 36329:PF3D7_1145400
uniprot id: Q8IHR4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

36329:PF3D7 0813900
gene id: 36329:PF3D7_0813900
uniprot id: Q8IAX5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

36329:PF3D7 0507200
gene id: 36329:PF3D7_0507200
uniprot id: Q8I430
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Expressed during the parasite blood stage, specifically in schizonts (at protein level).
messages: Secreted
messages: Serine protease which may cleave PFN/profilin.

36329:PF3D7 1241600
gene id: 36329:PF3D7_1241600
uniprot id: Q8I513
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 1239100
gene id: 36329:PF3D7_1239100
uniprot id: Q8I532
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

36329:PF3D7 1010100
gene id: 36329:PF3D7_1010100
uniprot id: Q8IJU4
names: Similarity
messages: Belongs to the proteasome inhibitor PI31 family.

36329:PF3D7 1232100
gene id: 36329:PF3D7_1232100
uniprot id: Q8I0V3
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

36329:PF3D7 1361200
gene id: 36329:PF3D7_1361200
uniprot id: Q8ID94
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1218400
gene id: 36329:PF3D7_1218400
uniprot id: Q8I5M4
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0912900
gene id: 36329:PF3D7_0912900
uniprot id: Q8I323
names: Similarity
messages: Belongs to the peptidase M67A family.

36329:PF3D7 1247200
gene id: 36329:PF3D7_1247200
uniprot id: Q8I4W0
names: Similarity
messages: Belongs to the STEEP1 family.

36329:PF3D7 1367000
gene id: 36329:PF3D7_1367000
uniprot id: Q8ID38
names: Similarity
messages: Belongs to the SKP1 family.

36329:PF3D7 1356900
gene id: 36329:PF3D7_1356900
uniprot id: P61075
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylates in presence of cyclin cyc-1 but not in presence of cyclin cyc-3.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: Expressed during the asexual blood stage; expression is low at the ring stage and peaks in trophozoites and schizonts (at protein level).
messages: May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.
messages: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it (By similarity). Activated by cyclin cyc-1 in vitro (PubMed:10722743, PubMed:12869562). Activated by cyclin cyc-3 in vitro (PubMed:12869562).
messages: Serine/threonine-protein kinase (PubMed:10722743, PubMed:12869562, PubMed:26094711). Involved in the control of the cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (PubMed:12869562). In schizonts, phosphorylates ORC1 resulting in its dissociation from DNA, relocalization to the cytoplasm and likely its degradation (PubMed:26094711).

36329:PF3D7 0623200
gene id: 36329:PF3D7_0623200
uniprot id: C6KT68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: May play a role in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
messages: Monomer (PubMed:17258767). Homodimer; disulfide linked (PubMed:17258767, PubMed:19736991). NADP binding accelerates formation of an inactive, disulfide-linked homodimer when the protein is exposed to air for 24 h or more (in vitro); the physiological relevance of this is uncertain (PubMed:17258767).
messages: apicoplast

36329:PF3D7 0918200.1
gene id: 36329:PF3D7_0918200.1
uniprot id: C0H543
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.

36329:PF3D7 1454400
gene id: 36329:PF3D7_1454400
uniprot id: A0A144A2H0
names: Similarity
messages: Belongs to the peptidase M24B family.

36329:PF3D7 1022200
gene id: 36329:PF3D7_1022200
uniprot id: Q8IJI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

36329:PF3D7 1449500
gene id: 36329:PF3D7_1449500
uniprot id: Q8IKY0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0311300
gene id: 36329:PF3D7_0311300
uniprot id: O77353
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

36329:PF3D7 0422300
gene id: 36329:PF3D7_0422300
uniprot id: Q8IFP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

36329:PF3D7 0515000
gene id: 36329:PF3D7_0515000
uniprot id: Q8I3V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CWC2 family.
messages: Nucleus

36329:PF3D7 1410200
gene id: 36329:PF3D7_1410200
uniprot id: Q8ILZ3
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

36329:PF3D7 1215900
gene id: 36329:PF3D7_1215900
uniprot id: Q8I5P8
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1134500
gene id: 36329:PF3D7_1134500
uniprot id: Q8II19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 1143400
gene id: 36329:PF3D7_1143400
uniprot id: Q8IHT2
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

36329:PF3D7 1428200
gene id: 36329:PF3D7_1428200
uniprot id: Q8ILI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

36329:PF3D7 1305600
gene id: 36329:PF3D7_1305600
uniprot id: Q8IEQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

36329:PF3D7 0812600
gene id: 36329:PF3D7_0812600
uniprot id: Q8IAW2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 1448500
gene id: 36329:PF3D7_1448500
uniprot id: Q8IKY8
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0419200
gene id: 36329:PF3D7_0419200
uniprot id: Q8I1P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: Membrane

36329:PF3D7 1429800
gene id: 36329:PF3D7_1429800
uniprot id: Q8ILG6
names: Subcellular Location Annotation
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane

36329:PF3D7 1120900
gene id: 36329:PF3D7_1120900
uniprot id: Q8IIF8
names: Similarity
messages: Belongs to the HSBP1 family.

36329:PF3D7 0208500
gene id: 36329:PF3D7_0208500
uniprot id: Q7KWJ1
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

36329:PF3D7 0705300
gene id: 36329:PF3D7_0705300
uniprot id: Q8IC17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC2 family.
messages: Nucleus

36329:PF3D7 1218600
gene id: 36329:PF3D7_1218600
uniprot id: Q8I5M2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 0304200
gene id: 36329:PF3D7_0304200
uniprot id: Q9NLB8
names: Subcellular Location Annotation
messages: Cell membrane

36329:PF3D7 1230600
gene id: 36329:PF3D7_1230600
uniprot id: Q8I5B4
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 1251500
gene id: 36329:PF3D7_1251500
uniprot id: A0A144A382
names: Similarity
messages: Belongs to the DEAD box helicase family.

36329:PF3D7 1034400
gene id: 36329:PF3D7_1034400
uniprot id: Q8IJ66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

36329:PF3D7 1468700
gene id: 36329:PF3D7_1468700
uniprot id: Q8IKF0
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

36329:PF3D7 1017400
gene id: 36329:PF3D7_1017400
uniprot id: Q8IJM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

36329:PF3D7 0932100
gene id: 36329:PF3D7_0932100
uniprot id: C0H584
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1107500
gene id: 36329:PF3D7_1107500
uniprot id: Q8IIS7
names: Similarity
messages: Belongs to the UXT family.

36329:PF3D7 1405800
gene id: 36329:PF3D7_1405800
uniprot id: Q8IM36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

36329:PF3D7 0709000
gene id: 36329:PF3D7_0709000
uniprot id: Q8IBZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRT-like transporter family.
messages: May regulate endogenous transporter.
messages: Vacuole membrane

36329:PF3D7 1438700
gene id: 36329:PF3D7_1438700
uniprot id: Q7KQM1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).
messages: Heterodimer of a catalytic subunit and a regulatory subunit, also known as the DNA primase complex.
messages: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).
messages: The presence of the regulatory subunit accelerates the kinetics of initiation and primer extension.

36329:PF3D7 0206700
gene id: 36329:PF3D7_0206700
uniprot id: Q7KWJ4
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

36329:PF3D7 0907800
gene id: 36329:PF3D7_0907800
uniprot id: Q8I373
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

36329:PF3D7 0719600
gene id: 36329:PF3D7_0719600
uniprot id: Q8IBQ6
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

36329:PF3D7 1143300
gene id: 36329:PF3D7_1143300
uniprot id: Q8IHT3
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

36329:PF3D7 0719700
gene id: 36329:PF3D7_0719700
uniprot id: Q8IBQ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

36329:PF3D7 1430600
gene id: 36329:PF3D7_1430600
uniprot id: Q8ILF8
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

36329:PF3D7 1207600
gene id: 36329:PF3D7_1207600
uniprot id: Q8I0X4
names: Similarity
messages: Belongs to the IPP transferase family.

36329:PF3D7 1440500
gene id: 36329:PF3D7_1440500
uniprot id: Q8IL65
names: Similarity
messages: Belongs to the allantoicase family.

36329:PF3D7 1439400
gene id: 36329:PF3D7_1439400
uniprot id: Q8IL75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Membrane

36329:PF3D7 0311200
gene id: 36329:PF3D7_0311200
uniprot id: O77354
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 0816800
gene id: 36329:PF3D7_0816800
uniprot id: Q8IB05
names: Similarity
messages: Belongs to the RecA family. DMC1 subfamily.

36329:PF3D7 0516200
gene id: 36329:PF3D7_0516200
uniprot id: A0A5K1K925
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS11 family.
messages: chloroplast

36329:PF3D7 1111000
gene id: 36329:PF3D7_1111000
uniprot id: Q8IIQ2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0510500
gene id: 36329:PF3D7_0510500
uniprot id: Q8I3Z9
names: Similarity
messages: Belongs to the type IB topoisomerase family.

36329:PF3D7 0611900
gene id: 36329:PF3D7_0611900
uniprot id: C6KSW3
names: Similarity
messages: Belongs to the LSM12 family.

36329:PF3D7 0931700
gene id: 36329:PF3D7_0931700
uniprot id: C0H581
names: Similarity
messages: Belongs to the PIH1 family.

36329:PF3D7 0922600
gene id: 36329:PF3D7_0922600
uniprot id: C0H551
names: Similarity
messages: Belongs to the glutamine synthetase family.

36329:PF3D7 0910700
gene id: 36329:PF3D7_0910700
uniprot id: Q8I345
names: Similarity
messages: Belongs to the actin family.

36329:PF3D7 1416900
gene id: 36329:PF3D7_1416900
uniprot id: Q8ILS7
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

36329:PF3D7 1316800
gene id: 36329:PF3D7_1316800
uniprot id: A0A5K1K9E7
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1107000
gene id: 36329:PF3D7_1107000
uniprot id: Q8IIT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

36329:PF3D7 1364900
gene id: 36329:PF3D7_1364900
uniprot id: Q8ID58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

36329:PF3D7 1125500
gene id: 36329:PF3D7_1125500
uniprot id: Q8IIA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures.
messages: Nucleus

36329:PF3D7 1219100
gene id: 36329:PF3D7_1219100
uniprot id: Q8I5L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

36329:PF3D7 1417300
gene id: 36329:PF3D7_1417300
uniprot id: Q8ILS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cytoplasm

36329:PF3D7 1117800
gene id: 36329:PF3D7_1117800
uniprot id: Q8IIJ0
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

36329:PF3D7 1144700
gene id: 36329:PF3D7_1144700
uniprot id: Q8IHS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tic20 family.
messages: Membrane

36329:PF3D7 1132200
gene id: 36329:PF3D7_1132200
uniprot id: Q8II43
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

36329:PF3D7 1132800
gene id: 36329:PF3D7_1132800
uniprot id: Q8II36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

36329:PF3D7 1414400
gene id: 36329:PF3D7_1414400
uniprot id: Q8ILV1
names: Similarity
messages: Belongs to the PPP phosphatase family.

36329:PF3D7 0109200
gene id: 36329:PF3D7_0109200
uniprot id: Q8I0V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

36329:PF3D7 1219700
gene id: 36329:PF3D7_1219700
uniprot id: Q7KQK1
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

36329:PF3D7 0808200
gene id: 36329:PF3D7_0808200
uniprot id: Q8IAS0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autocleaved into a p16 prodomain form and two mature forms p44 and p51.
messages: Belongs to the peptidase A1 family.
messages: During the asexual blood stage, processes key proteins essential for merozoite egress and invasion of host erythrocytes (PubMed:29074775, PubMed:32109369). Cleaves and activates proteases SUB1 and SUB2 (PubMed:29074775, PubMed:32109369). May process members of the EBL and Rh protein families (PubMed:32109369). Also cleaves apical membrane protein AMA1 (PubMed:29074775). During the mosquito vector stage and probably in ookinetes, cleaves CelTOS (PubMed:29074775).
messages: Inhibited by small molecule 49c (PubMed:29074775). Inhibited by small molecules WM382, WM4, and WM5 (PubMed:32109369).
messages: secretory vesicle

36329:PF3D7 1423000
gene id: 36329:PF3D7_1423000
uniprot id: Q8ILM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

36329:PF3D7 0512300
gene id: 36329:PF3D7_0512300
uniprot id: Q8I3Y3
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1415200
gene id: 36329:PF3D7_1415200
uniprot id: Q8ILU4
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

36329:PF3D7 1472700
gene id: 36329:PF3D7_1472700
uniprot id: Q8IKB1
names: Function
names: Similarity
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

36329:PF3D7 0806200
gene id: 36329:PF3D7_0806200
uniprot id: C0H4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane

36329:PF3D7 1034200
gene id: 36329:PF3D7_1034200
uniprot id: Q8IJ68
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

36329:PF3D7 0916500
gene id: 36329:PF3D7_0916500
uniprot id: C0H540
names: Similarity
messages: Belongs to the UFD1 family.

36329:PF3D7 0424100
gene id: 36329:PF3D7_0424100
uniprot id: Q8IFM5
names: Biotechnology
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cleaved into a 45kDa form during merozoite invasion of host erythrocyte.
messages: Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:25583518, PubMed:27374406, PubMed:25296023, PubMed:22080952, PubMed:18827878, PubMed:19000690, PubMed:31204103, PubMed:28186186, PubMed:28409866). By binding P113 at the surface of the merozoite and human BSG/basigin on the erythrocyte membrane, leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes (PubMed:25583518, PubMed:27374406, PubMed:25296023, PubMed:22080952, PubMed:28186186). In addition, the interaction with BSG results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:27374406, PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866).
messages: Expressed during parasite asexual blood stages, specifically at the schizont stage and in free merozoites (at protein level).
messages: Forms a complex composed of RH5, P113 and human BSG/basigin; the complex bridges the merozoite and host erythrocyte membranes (PubMed:28186186). Within the complex, interacts (via C-terminus) with human BSG/basigin isoform 2 (via the extracellular domain); the interaction is independent of BSG glycosylation status (PubMed:22080952, PubMed:25296023, PubMed:28186186, PubMed:24297912, PubMed:30542156, PubMed:28096331). Weakly interacts with P.troglodytes BSG but not with G.gorilla BSG (PubMed:24297912). Also, interacts (via N-terminus) with P113; the interaction tethers RH5 to the merozoite membrane (PubMed:28186186). Component of the PfRH5 adhesion complex composed of 1 copy of CyRPA, RH5 and RIPR; the complex is formed during merozoite invasion of host erythrocytes specifically at the interface between the parasite and host membranes (PubMed:25583518, PubMed:27374406, PubMed:28186186, PubMed:21909261, PubMed:30542156). Within the complex, interacts with CyRPA (PubMed:28186186, PubMed:30542156). CyRPA recruits RIPR to the RH5-P113-BSG complex; the formation of the PfRH5 adhesion complex increases the affinity of RH5 for BSG and probably leads to the release of RH5 from P113 while maintaining the interaction of the PfRH5 adhesion complex with BSG (PubMed:28186186, PubMed:30542156).
messages: Host cell membrane
messages: Potential candidate for the development of parasite blood stage vaccines. In vitro and in vivo, induces neutralizing antibodies capable of inhibiting merozoite invasion of host erythrocytes.
messages: Secreted
messages: rhoptry lumen

36329:PF3D7 0929000
gene id: 36329:PF3D7_0929000
uniprot id: Q8I2M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

36329:PF3D7 1222300
gene id: 36329:PF3D7_1222300
uniprot id: Q8I0V4
names: Similarity
messages: Belongs to the heat shock protein 90 family.

36329:PF3D7 1220500
gene id: 36329:PF3D7_1220500
uniprot id: Q8I5K8
names: Function
names: Similarity
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.

36329:PF3D7 0724900
gene id: 36329:PF3D7_0724900
uniprot id: Q8IBK2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

36329:PF3D7 1402500
gene id: 36329:PF3D7_1402500
uniprot id: Q8IM64
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

36329:PF3D7 0308900
gene id: 36329:PF3D7_0308900
uniprot id: O77327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

36329:PF3D7 0218400
gene id: 36329:PF3D7_0218400
uniprot id: O96264
names: Similarity
messages: Belongs to the DEAD box helicase family.

36329:PF3D7 1235600
gene id: 36329:PF3D7_1235600
uniprot id: Q8I566
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the interconversion of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, a source of one-carbon units used by thymidylate synthase to convert dUMP to dTMP for DNA synthesis (PubMed:11071283, PubMed:19591883, PubMed:24914963). Binds to its own mRNA and to the mRNA of bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) in vitro; the physiological relevance of this interaction is not clear (PubMed:19591883).
messages: Cytoplasm
messages: Expressed during the parasite erythrocyte stages, namely in trophozoites and schizonts.
messages: Homodimer.
messages: Mitochondrion matrix
messages: Nucleus
messages: Redox regulation; active in reducing conditions, inactive in oxidizing conditions. The reduction of the cysteine pairs allows the access binding of the tetrahydrofolate substrate to its binding site. This mechanism appears to be unique to Plasmodium species.
messages: apicoplast

36329:PF3D7 1310900
gene id: 36329:PF3D7_1310900
uniprot id: Q8I6T8
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

36329:PF3D7 0603100
gene id: 36329:PF3D7_0603100
uniprot id: C6KSN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF-assemblin family.
messages: cytoskeleton

36329:PF3D7 1433000
gene id: 36329:PF3D7_1433000
uniprot id: C6S3I4
names: Similarity
messages: Belongs to the NOP10 family.

36329:PF3D7 1337800
gene id: 36329:PF3D7_1337800
uniprot id: A0A5K1K8H0
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by calcium (PubMed:20466936). Upon calcium binding to the EF-hand domains, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (By similarity). This, in turn, may facilitate the autophosphorylation of the activation loop at Thr-285, which leads to the kinase activation (By similarity).
messages: Autophosphorylated in vitro.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
messages: Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:20466936, PubMed:31915223). Plays a central role in host erythrocytes and hepatocytes infection cycles (PubMed:20466936, PubMed:29487234). During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK4 (By similarity). Involved in merosome egress from host hepatocytes, probably together with CDPK4 (By similarity). Required for the release of hepatic merozoites from merosomes in the host blood stream (By similarity). During the asexual blood stage, required for merozoite egress from host erythrocytes by triggering microneme secretion (PubMed:20466936, PubMed:29487234). Phosphorylates transporter NPT1 at late schizont stage (PubMed:31915223).
messages: Cell membrane
messages: Cytoplasm
messages: Expressed at the blood stage in schizonts (at protein level).
messages: Impaired replication in host erythrocytes (PubMed:20466936). Parasite development is arrested at the late schizont stage before the rupture of the parasitophorous vacuole membrane rupture, however, the daughter merozoites are fully mature and their number per schizont is not affected (PubMed:20466936, PubMed:29487234). Loss of secretion of AMA1-containing and EBA175-containing micronemes (PubMed:29487234). SUB1-mediated processing of AMA1 and SERA5, which is part of the protease cascade involved in parasite egress, is reduced (PubMed:29487234). At the late schizont stage, phosphorylation of several transmembrane- and membrane-associated proteins and proteins associated with transport activity is reduced (PubMed:31915223).
messages: May be palmitoylated.
messages: The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive (By similarity). The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains (By similarity).
messages: microneme membrane

36329:PF3D7 1450000
gene id: 36329:PF3D7_1450000
uniprot id: Q8IKX5
names: Similarity
messages: Belongs to the protein kinase superfamily.

36329:PF3D7 1138400
gene id: 36329:PF3D7_1138400
uniprot id: Q8IHY1
names: Caution
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 2 magnesium ions per subunit (By similarity). Is also active with manganese (in vitro) (By similarity).
messages: Catalyzes the synthesis of the second messenger cGMP from GTP (Probable). In asexual blood stage schizonts, required for cGMP production which is essential for PKG activation, PKG-dependent Ca(2+) release, and ultimately merozoite egress from host erythrocytes (PubMed:33500341).
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: During the parasite blood stage, highly expressed in mature schizonts and in gametocytes.
messages: In the C-terminal section; belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: In the N-terminal section; belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Knockout at the asexual blood stage causes growth arrest (PubMed:33500341). Mature schizonts accumulate in host erythrocytes due to a defect in merozoite egress (PubMed:33500341). Lack of swelling or rupture of the parasitophorous vacuole membrane and, no Ca(2+) release from intracellular stores and no secretion of protease SERA5 (PubMed:33500341). Mature schizonts fail to synthesize cGMP; no defect in cAMP levels (PubMed:33500341).
messages: The N-terminus contains a P-type ATPase-like domain which may be important for guanylate cyclase activity.
messages: Unlike the two guanylate cyclase domains of GCbeta, the guanylate cyclase domains 1 and 2 of GCalpha lack catalytic activity when expressed on their own or in combination.

36329:PF3D7 0307400
gene id: 36329:PF3D7_0307400
uniprot id: O97252
names: Similarity
messages: Belongs to the peptidase S14 family.

36329:PF3D7 1224900
gene id: 36329:PF3D7_1224900
uniprot id: Q8I5G8
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1314200
gene id: 36329:PF3D7_1314200
uniprot id: Q8IEH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

36329:PF3D7 1474100
gene id: 36329:PF3D7_1474100
uniprot id: Q8IK97
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

36329:PF3D7 1108400
gene id: 36329:PF3D7_1108400
uniprot id: Q8IIR9
names: Similarity
messages: Belongs to the protein kinase superfamily.

36329:PF3D7 0511200
gene id: 36329:PF3D7_0511200
uniprot id: Q8I0W9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

36329:PF3D7 0110400
gene id: 36329:PF3D7_0110400
uniprot id: Q8I241
names: Similarity
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

36329:PF3D7 0915000
gene id: 36329:PF3D7_0915000
uniprot id: Q8I302
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

36329:PF3D7 1015300
gene id: 36329:PF3D7_1015300
uniprot id: Q8IJP2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins (PubMed:16983082, PubMed:27023914). The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity). May play an important role in parasite growth during the blood asexual stage (PubMed:16983082).
messages: Highest activity with zinc and cobalt ions, and low activity with manganese or divalent iron ions (PubMed:27023914). Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone (By similarity).
messages: Inhibited by pyrimidine derivative XC11.

36329:PF3D7 0505500
gene id: 36329:PF3D7_0505500
uniprot id: Q8I447
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

36329:PF3D7 1351400
gene id: 36329:PF3D7_1351400
uniprot id: Q8IDI5
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

36329:PF3D7 0219400.1
gene id: 36329:PF3D7_0219400.1
uniprot id: Q8I655
names: Similarity
messages: Belongs to the RAMP4 family.

36329:PF3D7 0933900
gene id: 36329:PF3D7_0933900
uniprot id: Q8I2H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

36329:PF3D7 0518000
gene id: 36329:PF3D7_0518000
uniprot id: C0H4E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Nucleus

36329:PF3D7 0211300
gene id: 36329:PF3D7_0211300
uniprot id: Q8I661
names: Similarity
messages: Belongs to the CBP3 family.

36329:PF3D7 1442200
gene id: 36329:PF3D7_1442200
uniprot id: Q8IL49
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

36329:PF3D7 1126000
gene id: 36329:PF3D7_1126000
uniprot id: Q8IIA4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

36329:PF3D7 1215000
gene id: 36329:PF3D7_1215000
uniprot id: Q8I5Q6
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

36329:PF3D7 0915100
gene id: 36329:PF3D7_0915100
uniprot id: Q8I301
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 0317600
gene id: 36329:PF3D7_0317600
uniprot id: O77381
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

36329:PF3D7 0914300
gene id: 36329:PF3D7_0914300
uniprot id: C0H537
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

36329:PF3D7 1463700
gene id: 36329:PF3D7_1463700
uniprot id: Q8IKK0
names: Similarity
messages: Belongs to the cyclin family.

36329:PF3D7 0216700.1
gene id: 36329:PF3D7_0216700.1
uniprot id: Q8I659
names: Biotechnology
names: Function
names: Similarity
messages: Belongs to the ATG11 family.
messages: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1342900
gene id: 36329:PF3D7_1342900
uniprot id: C0H5G5
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1470900
gene id: 36329:PF3D7_1470900
uniprot id: Q8IKC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 0917900
gene id: 36329:PF3D7_0917900
uniprot id: Q8I2X4
names: Similarity
messages: Belongs to the heat shock protein 70 family.

36329:PF3D7 0610000
gene id: 36329:PF3D7_0610000
uniprot id: C6KSU7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

36329:PF3D7 0622800
gene id: 36329:PF3D7_0622800
uniprot id: C6KT64
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 0213900
gene id: 36329:PF3D7_0213900
uniprot id: O96219
names: Similarity
messages: Belongs to the RPAP2 family.

36329:PF3D7 1250700
gene id: 36329:PF3D7_1250700
uniprot id: Q8I4S7
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0703100
gene id: 36329:PF3D7_0703100
uniprot id: Q8IC39
names: Similarity
messages: Belongs to the MIP18 family.

36329:PF3D7 0107000.1
gene id: 36329:PF3D7_0107000.1
uniprot id: Q8I272
names: Similarity
messages: Belongs to the centrin family.

36329:PF3D7 0305000
gene id: 36329:PF3D7_0305000
uniprot id: O97235
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

36329:PF3D7 1232200
gene id: 36329:PF3D7_1232200
uniprot id: Q8I5A0
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

36329:PF3D7 1451300
gene id: 36329:PF3D7_1451300
uniprot id: Q8IKW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

36329:PF3D7 1446600
gene id: 36329:PF3D7_1446600
uniprot id: Q8IL07
names: Function
names: Similarity
messages: Belongs to the centrin family.
messages: Plays a fundamental role in microtubule organizing center structure and function. Component of the infraciliary lattice (ICL) and the ciliary basal bodies.

36329:PF3D7 0516800
gene id: 36329:PF3D7_0516800
uniprot id: Q8I3U0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0506800
gene id: 36329:PF3D7_0506800
uniprot id: Q8I434
names: Similarity
messages: Belongs to the TCF25 family.

36329:PF3D7 1023200
gene id: 36329:PF3D7_1023200
uniprot id: Q8IJH3
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

36329:PF3D7 1467500
gene id: 36329:PF3D7_1467500
uniprot id: Q8IKG2
names: Similarity
messages: Belongs to the KIN17 family.

36329:PF3D7 1129400
gene id: 36329:PF3D7_1129400
uniprot id: Q8II69
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

36329:PF3D7 0422800
gene id: 36329:PF3D7_0422800
uniprot id: C0H4C0
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0417800
gene id: 36329:PF3D7_0417800
uniprot id: Q8I1Q9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

36329:PF3D7 1338100
gene id: 36329:PF3D7_1338100
uniprot id: A0A5K1K9F3
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

36329:PF3D7 1104800
gene id: 36329:PF3D7_1104800
uniprot id: Q8IIV4
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0420100
gene id: 36329:PF3D7_0420100
uniprot id: Q8I1N8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

36329:PF3D7 0629600
gene id: 36329:PF3D7_0629600
uniprot id: C6KTD1
names: Similarity
messages: Belongs to the RRP7 family.

36329:PF3D7 1360800
gene id: 36329:PF3D7_1360800
uniprot id: Q76NL8
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Binds 1 zinc ion per subunit.
messages: Does not require processing for targeting to the food vacuole or maturation.
messages: Expressed during the asexual blood stage; expression begins at the late ring, early trophozoite stage, increases in the mid-trophozoite stage, and persists throughout the schizont stage (at protein level).
messages: In the food vacuole, acts downstream of proteases plasmepsins PMI and PMII and falcipains during the catabolism of host hemoglobin by cleaving peptide fragments of alpha and beta hemoglobin subunits generated by PMI and PMII and falcipains (PubMed:17074076). In the apicoplast, degrades apicoplast transit peptides after their cleavage (PubMed:17074076). Prefers bulky hydrophobic amino acids in the P1' position at both acidic and neutral pH (By similarity). At P2', prefers hydrophobic residues at acidic pH; at neutral pH, these same residues are abundant but prefers Arg (By similarity). At P3', prefers hydrophobic residues, especially Met, at both pH conditions. At P4' and P5', prefers acidic residues at acidic pH, however, at neutral pH, the enzyme is less selective at these positions (By similarity). The optimal site cleavage at acidic pH is YNEHS-|-FFMEE and, at neutral pH, MKRHS-|-FRMRG (By similarity).
messages: Monomer.
messages: Vacuole membrane
messages: Vesicle
messages: apicoplast

36329:PF3D7 0409200
gene id: 36329:PF3D7_0409200
uniprot id: Q9U0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

36329:PF3D7 1474500
gene id: 36329:PF3D7_1474500
uniprot id: Q8IK93
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1018000
gene id: 36329:PF3D7_1018000
uniprot id: Q8I715
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

36329:PF3D7 1330400.1
gene id: 36329:PF3D7_1330400.1
uniprot id: Q8IE22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1328100
gene id: 36329:PF3D7_1328100
uniprot id: Q8I6T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 1424400
gene id: 36329:PF3D7_1424400
uniprot id: Q8ILL2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

36329:PF3D7 1442000
gene id: 36329:PF3D7_1442000
uniprot id: Q8IL50
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

36329:PF3D7 1331800
gene id: 36329:PF3D7_1331800
uniprot id: Q8IE09
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

36329:PF3D7 1132900
gene id: 36329:PF3D7_1132900
uniprot id: Q8II35
names: Similarity
messages: Belongs to the GcvH family.

36329:PF3D7 0214000
gene id: 36329:PF3D7_0214000
uniprot id: O96220
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

36329:PF3D7 0210300
gene id: 36329:PF3D7_0210300
uniprot id: O96186
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1333700
gene id: 36329:PF3D7_1333700
uniprot id: Q8IDZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Nucleus

36329:PF3D7 0904800
gene id: 36329:PF3D7_0904800
uniprot id: Q8I3A1
names: Similarity
messages: Belongs to the replication factor A protein 1 family.

36329:PF3D7 0108800
gene id: 36329:PF3D7_0108800
uniprot id: Q8I254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 0613900
gene id: 36329:PF3D7_0613900
uniprot id: C6KSY1
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 1408900
gene id: 36329:PF3D7_1408900
uniprot id: Q8IM07
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

36329:PF3D7 0519300
gene id: 36329:PF3D7_0519300
uniprot id: Q8I0W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

36329:PF3D7 1226600
gene id: 36329:PF3D7_1226600
uniprot id: Q7KQJ9
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCNA family.
messages: Chromosome
messages: Cytoplasm
messages: Expressed during the asexual blood stage; expression is low at the ring stage, increases in trophozoites and early schizonts and sharply decreases in late schizonts (at protein level) (PubMed:12413950, PubMed:12464414, PubMed:26251451). Expressed during the sexual blood stage (PubMed:12464414).
messages: Homotrimer (PubMed:12413950, PubMed:12464414, PubMed:26251451). Oligomer (PubMed:12413950). Interacts with ORC1 (via PIP-box motif) (PubMed:26251451). Interacts with FEN1 (PubMed:26251451).
messages: Induced by DNA damage (at protein level).
messages: May be involved in DNA damage response (PubMed:26251451). Appears not to be involved in DNA replication in trophozoites (PubMed:26251451).
messages: Nucleus

36329:PF3D7 1410000
gene id: 36329:PF3D7_1410000
uniprot id: Q8ILZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

36329:PF3D7 1469100
gene id: 36329:PF3D7_1469100
uniprot id: Q8IKE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR1 family.
messages: Golgi apparatus membrane
messages: Membrane

36329:PF3D7 0616200
gene id: 36329:PF3D7_0616200
uniprot id: C6KT03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

36329:PF3D7 1458000
gene id: 36329:PF3D7_1458000
uniprot id: Q8I6V0
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 1213600
gene id: 36329:PF3D7_1213600
uniprot id: Q8I5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

36329:PF3D7 1127300
gene id: 36329:PF3D7_1127300
uniprot id: Q8II90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Nucleus

36329:PF3D7 0624900
gene id: 36329:PF3D7_0624900
uniprot id: C6KT85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: cytoskeleton

36329:PF3D7 1462700
gene id: 36329:PF3D7_1462700
uniprot id: Q8I6U9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 1020800
gene id: 36329:PF3D7_1020800
uniprot id: Q8IJJ4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

36329:PF3D7 1426100
gene id: 36329:PF3D7_1426100
uniprot id: Q8ILK2
names: Similarity
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Part of the nascent polypeptide-associated complex (NAC).

36329:PF3D7 1104000
gene id: 36329:PF3D7_1104000
uniprot id: Q8IIW2
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

36329:PF3D7 0514600
gene id: 36329:PF3D7_0514600
uniprot id: Q8I3W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Homodimer.
messages: Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.

36329:PF3D7 0714300
gene id: 36329:PF3D7_0714300
uniprot id: Q8IBV4
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0109400
gene id: 36329:PF3D7_0109400
uniprot id: Q8I250
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: cytoskeleton

36329:PF3D7 1318800
gene id: 36329:PF3D7_1318800
uniprot id: Q8IEC8
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0423100
gene id: 36329:PF3D7_0423100
uniprot id: Q8IFN5
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

36329:PF3D7 0311700
gene id: 36329:PF3D7_0311700
uniprot id: O77350
names: Similarity
messages: Belongs to the peptidase A1 family.

36329:PF3D7 1357200
gene id: 36329:PF3D7_1357200
uniprot id: Q8IDD3
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

36329:PF3D7 1217900
gene id: 36329:PF3D7_1217900
uniprot id: Q8I5M9
names: Similarity
messages: Belongs to the DeSI family.

36329:PF3D7 1320800
gene id: 36329:PF3D7_1320800
uniprot id: Q8IEA6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

36329:PF3D7 1316600
gene id: 36329:PF3D7_1316600
uniprot id: Q8IEE9
names: Similarity
messages: Belongs to the cytidylyltransferase family.

36329:PF3D7 1335400
gene id: 36329:PF3D7_1335400
uniprot id: Q8IDX6
names: Biotechnology
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Does not affect merozoite invasion of host erythrocytes, either untreated or treated with neuraminidase, trypsin or chymotrypsin.
messages: During the asexual blood stage, binds to a chymotrypsin sensitive, neuraminidase and trypsin resistant receptor on the surface of the host erythrocyte (PubMed:21628513). Despite its binding capacity, appears to be dispensable for merozoite invasion of host erythrocytes (PubMed:12606570, PubMed:21698217).
messages: During the asexual blood stage, binds to a trypsin-resistant and chymotrypsin and neuraminidase sensitive receptor on the surface of the host erythrocyte.
messages: Expressed during parasite asexual blood stages, specifically at the late schizont stage prior to merozoite release and in free merozoites (at protein level).
messages: Forms a heterodimer composed of the 285 kDa and the 85 kDa forms.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: Proteolytically processed into multiple fragments following schizont rupture (PubMed:21628513, PubMed:12228308, PubMed:21698217). In the mature schizont stage prior to merozoite release, full length RH2b is processed post-Golgi into C-terminal 285 kDa and N-terminal 85 kDa forms (PubMed:21628513, PubMed:21698217). During merozoite invasion of host erythrocytes, further processing occurs generating a 140 kDa C-terminal form (PubMed:21628513). At the same time, the C-terminal transmembrane region is probably cleaved, probably by a rhomboid protease, to shed all the different processed protein forms from the membrane leaving a transmembrane 7 kDa form on the merozoite surface (PubMed:21628513, PubMed:21698217).
messages: RH2a expression levels greatly vary between isolates; levels are high in isolates 3D7, T996, HB3, D10, 7G8, K1, Pf120 and W2mef, and undetectable in isolates MCAMP, FCB1, T994 and FCR3 (PubMed:12228308, PubMed:12606570). A similar variation in expression affects other reticulocyte-binding proteins such as RH2b and RH1 (PubMed:12228308, PubMed:12606570). The expression pattern of RH1, RH2a and RH2b allows the strain to use different invasion pathways to enter erythrocytes (Probable). This provides a mechanism of phenotypic variation to evade host immune responses and to adapt to the polymorphic nature of the erythrocyte receptors in human populations (Probable).
messages: Secreted
messages: rhoptry
messages: tight junction

36329:PF3D7 1304200.1
gene id: 36329:PF3D7_1304200.1
uniprot id: C0H599
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 1107700
gene id: 36329:PF3D7_1107700
uniprot id: Q8IIS5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Expressed during the parasite blood stage, including in rings, trophozoites and schizonts (at protein level) (PubMed:14698441). Expression increases in trophozoites and schizonts (PubMed:14698441).
messages: Interacts with dual specificity protein phosphatase YVH1.
messages: Nucleus
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

36329:PF3D7 1344600
gene id: 36329:PF3D7_1344600
uniprot id: Q8IDQ0
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Expressed maximally in the early stages and late stages of the parasite erythrocytic development.
messages: apicoplast

36329:PF3D7 0814000
gene id: 36329:PF3D7_0814000
uniprot id: Q8IAX6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

36329:PF3D7 1020500
gene id: 36329:PF3D7_1020500
uniprot id: Q8IJJ7
names: Similarity
messages: Belongs to the Iojap/RsfS family.

36329:PF3D7 1361900
gene id: 36329:PF3D7_1361900
uniprot id: P61074
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxiliary protein of DNA polymerase delta and is involved in the control of DNA replication by increasing the polymerase processibility during elongation of the leading strand (By similarity). Involved in DNA damage response (PubMed:26251451).
messages: Belongs to the PCNA family.
messages: Chromosome
messages: Cytoplasm
messages: Expressed during the asexual blood stage, specifically during the trophozoite and schizont stages (at protein level).
messages: Homotrimer (PubMed:26251451, PubMed:30052905). Interacts with ORC1 (via PIP-box motif); the interaction occurs during DNA replication in trophozoites (PubMed:18554328, PubMed:26251451). Interacts with ORC5; the interaction occurs during the trophozoite stage but not at the late schizont stage (PubMed:18554328, PubMed:19633266, PubMed:26251451). Interacts with FEN1 (PubMed:26251451).
messages: Induced by DNA damage (at protein level).
messages: Nucleus

36329:PF3D7 1353700
gene id: 36329:PF3D7_1353700
uniprot id: Q8IDG4
names: Similarity
messages: Belongs to the MGR2 family.

36329:PF3D7 0209100
gene id: 36329:PF3D7_0209100
uniprot id: O96176
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0215700
gene id: 36329:PF3D7_0215700
uniprot id: O96236
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: apicoplast

36329:PF3D7 1407300
gene id: 36329:PF3D7_1407300
uniprot id: Q8IM21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus

36329:PF3D7 1030500
gene id: 36329:PF3D7_1030500
uniprot id: Q8IJA0
names: Similarity
messages: Belongs to the proteasome subunit S11 family.

36329:PF3D7 1116800
gene id: 36329:PF3D7_1116800
uniprot id: Q8IIJ8
names: Similarity
messages: Belongs to the ClpA/ClpB family.

36329:PF3D7 1340900
gene id: 36329:PF3D7_1340900
uniprot id: Q8IDS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

36329:PF3D7 1123800
gene id: 36329:PF3D7_1123800
uniprot id: Q8IIC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

36329:PF3D7 1436000
gene id: 36329:PF3D7_1436000
uniprot id: Q8ILA4
names: Similarity
messages: Belongs to the GPI family.

36329:PF3D7 1017900
gene id: 36329:PF3D7_1017900
uniprot id: Q8IJM0
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

36329:PF3D7 1123100
gene id: 36329:PF3D7_1123100
uniprot id: Q8IID2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

36329:PF3D7 1248600
gene id: 36329:PF3D7_1248600
uniprot id: Q8I4U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1230900
gene id: 36329:PF3D7_1230900
uniprot id: A0A144A2N6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

36329:PF3D7 1013600
gene id: 36329:PF3D7_1013600
uniprot id: Q8IJQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

36329:PF3D7 0618300
gene id: 36329:PF3D7_0618300
uniprot id: C6KT23
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

36329:PF3D7 0813800
gene id: 36329:PF3D7_0813800
uniprot id: Q8IAX4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

36329:PF3D7 0706400
gene id: 36329:PF3D7_0706400
uniprot id: C0H4L5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

36329:PF3D7 0722100
gene id: 36329:PF3D7_0722100
uniprot id: Q8I6Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Nucleus

36329:PF3D7 1236700
gene id: 36329:PF3D7_1236700
uniprot id: Q8I556
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

36329:PF3D7 1124400
gene id: 36329:PF3D7_1124400
uniprot id: Q8IIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

36329:PF3D7 1143100
gene id: 36329:PF3D7_1143100
uniprot id: Q8IHT5
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0512000
gene id: 36329:PF3D7_0512000
uniprot id: Q8I3Y6
names: Biotechnology
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1105400
gene id: 36329:PF3D7_1105400
uniprot id: Q8IIU8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

36329:PF3D7 1303900
gene id: 36329:PF3D7_1303900
uniprot id: C0H597
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1358300
gene id: 36329:PF3D7_1358300
uniprot id: A0A5K1K991
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1330000.1
gene id: 36329:PF3D7_1330000.1
uniprot id: Q8IE26
names: Similarity
messages: Belongs to the PITHD1 family.

36329:PF3D7 1120300
gene id: 36329:PF3D7_1120300
uniprot id: Q8IIG4
names: Biotechnology
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis (By similarity). Involved in the development of the sporozoite in the mosquito vector midgut (By similarity).
messages: Mitochondrion inner membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0609800
gene id: 36329:PF3D7_0609800
uniprot id: C6KSU5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

36329:PF3D7 0509200
gene id: 36329:PF3D7_0509200
uniprot id: Q8I412
names: Similarity
messages: Belongs to the DNAAF1 family.

36329:PF3D7 1434200
gene id: 36329:PF3D7_1434200
uniprot id: P62203
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calmodulin family.
messages: Calmodulin is not involved in the mechanism of chloroquine resistance.
messages: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (PubMed:32821880). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (PubMed:32821880).
messages: Cytoplasm

36329:PF3D7 1430100
gene id: 36329:PF3D7_1430100
uniprot id: Q8ILG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

36329:PF3D7 0513300
gene id: 36329:PF3D7_0513300
uniprot id: Q8I3X4
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: As part of the purine salvage pathway, catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:18957439, PubMed:14982926, PubMed:16131758, PubMed:19575810, PubMed:24416224, PubMed:29440412). Preferentially acts on inosine and guanosine, and to a lesser extent on 2'-deoxyguanosine and guanosine (PubMed:14982926, PubMed:16131758, PubMed:19575810). Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Generates hypoxanthine from both the purine salvage pathway and from polyamine metabolism which is required for nucleic acids synthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Has no activity towards adenosine (By similarity).
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Expressed during the parasite blood stage, including in trophozoites (at protein level).
messages: Homohexamer; trimer of homodimers.
messages: Inhibited by Immucillin-H and 5'-methylthio-Immucillin-H (PubMed:14982926, PubMed:24416224). Inhibited by 5'-deaza-1'-aza-2c-deoxy-1'-(9-methylene)-Immucilin-G (DADMe-ImmG) (PubMed:29440412).
messages: Severe growth defect in host erythrocytes which is rescued by the addition of exogenous purines (PubMed:18957439). Loss of purine nucleoside phosphorylase activity (PubMed:18957439).

36329:PF3D7 0816900
gene id: 36329:PF3D7_0816900
uniprot id: Q8IB06
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:18973776). Has very low activity with CTP, GTP, ITP and UTP and no activity with GMP, UMP or IMP in vitro (PubMed:18973776).
messages: May be palmitoylated at Cys-4 which stabilizes cell membrane localization of the myristoylated protein.
messages: Monomer (PubMed:18973776). Oligomer (PubMed:18973776). Heterodimer composed of NMT and AK2; AK2 myristoylation stabilizes the complex (PubMed:18973776).
messages: Myristoylation is required for cell membrane localization.
messages: Parasitophorous vacuole membrane

36329:PF3D7 0935100
gene id: 36329:PF3D7_0935100
uniprot id: C0H590
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

36329:PF3D7 1411900
gene id: 36329:PF3D7_1411900
uniprot id: Q8ILX6
names: Similarity
messages: Belongs to the nuclease type I family.

36329:PF3D7 1443900
gene id: 36329:PF3D7_1443900
uniprot id: Q8IL32
names: Similarity
messages: Belongs to the heat shock protein 90 family.

36329:PF3D7 1323000
gene id: 36329:PF3D7_1323000
uniprot id: Q8I6T4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

36329:PF3D7 0110900
gene id: 36329:PF3D7_0110900
uniprot id: Q8I236
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.
messages: Cytoplasm

36329:PF3D7 1209200
gene id: 36329:PF3D7_1209200
uniprot id: Q8I5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

36329:PF3D7 0304400.1
gene id: 36329:PF3D7_0304400.1
uniprot id: O97231
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit (PubMed:24913268, PubMed:26432834, PubMed:28288098). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28288098). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).
messages: Cytoplasm
messages: Expressed during the asexual blood stage (at protein level).

36329:PF3D7 0318900
gene id: 36329:PF3D7_0318900
uniprot id: O77369
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1354300
gene id: 36329:PF3D7_1354300
uniprot id: Q8IDF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
messages: nucleolus

36329:PF3D7 1337200
gene id: 36329:PF3D7_1337200
uniprot id: Q8IDW0
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Homodimer.

36329:PF3D7 1144000
gene id: 36329:PF3D7_1144000
uniprot id: Q8IHS5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS21 family.

36329:PF3D7 1126200
gene id: 36329:PF3D7_1126200
uniprot id: Q8IIA2
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

36329:PF3D7 1244000
gene id: 36329:PF3D7_1244000
uniprot id: Q8I4Z0
names: Function
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

36329:PF3D7 1130600
gene id: 36329:PF3D7_1130600
uniprot id: Q8II58
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

36329:PF3D7 1237200
gene id: 36329:PF3D7_1237200
uniprot id: Q8I551
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus

36329:PF3D7 1308900
gene id: 36329:PF3D7_1308900
uniprot id: Q8IEM5
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

36329:PF3D7 0822100
gene id: 36329:PF3D7_0822100
uniprot id: Q8IB55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

36329:PF3D7 0105800
gene id: 36329:PF3D7_0105800
uniprot id: Q8I283
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

36329:PF3D7 0206600
gene id: 36329:PF3D7_0206600
uniprot id: O96159
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

36329:PF3D7 0605200
gene id: 36329:PF3D7_0605200
uniprot id: C6KSQ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0415000
gene id: 36329:PF3D7_0415000
uniprot id: Q8I1T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer.

36329:PF3D7 1347700
gene id: 36329:PF3D7_1347700
uniprot id: Q8IDM2
names: Similarity
messages: Belongs to the cytidylyltransferase family.

36329:PF3D7 0705700
gene id: 36329:PF3D7_0705700
uniprot id: C0H4K8
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

36329:PF3D7 0630500
gene id: 36329:PF3D7_0630500
uniprot id: C6KTE0
names: Subcellular Location Annotation
messages: nucleolus

36329:PF3D7 0907900
gene id: 36329:PF3D7_0907900
uniprot id: Q8I372
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

36329:PF3D7 0526900
gene id: 36329:PF3D7_0526900
uniprot id: A0A5K1K8K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

36329:PF3D7 1020400
gene id: 36329:PF3D7_1020400
uniprot id: Q8IJJ8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0310100
gene id: 36329:PF3D7_0310100
uniprot id: Q9NJU9
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by calcium (Probable). Upon calcium binding to the EF-hand domain 2, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (Probable). This, in turn, may facilitate the autophosphorylation of the activation loop at Thr-279, which leads to the kinase activation (By similarity).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
messages: Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (By similarity). In the mosquito midgut, regulates the gliding motility of the ookinete which is essential for the ookinete to invade the midgut epithelium (By similarity). However, another study showed that while required for ookinete invasion of the midgut epithelium, is not required for ookinete gliding motility (By similarity).
messages: Cytoplasm
messages: Expressed in sexual stages, but not in asexual stages.
messages: The EF-hand domain 1 cannot bind calcium due to the presence of a Lys instead of an Asp at position 435 and a Gln instead of a Glu at position 442 preventing calcium binding (PubMed:28746405, PubMed:21287613). The EF-hand domains 3 and 4 probably bind calcium constitutively when calcium levels are low, while the EF-hand domain 2 binds calcium following an increase in calcium levels (PubMed:21287613).
messages: The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive. The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains.

36329:PF3D7 1250300
gene id: 36329:PF3D7_1250300
uniprot id: Q8I4T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VPS26 family.
messages: Component of the retromer complex, composed of VPS26, VPS29 and VPS35 (PubMed:29654975). As part of the retromer complex, interacts with the sorting receptor SORTLR/sortilin (PubMed:29654975). Interacts with GTPase RAB7 (PubMed:32512169).
messages: Plays a role in vesicular protein sorting (By similarity). Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport (By similarity).

36329:PF3D7 1038100
gene id: 36329:PF3D7_1038100
uniprot id: Q8IJ27
names: Similarity
messages: Belongs to the Rab GDI family.

36329:PF3D7 1436800
gene id: 36329:PF3D7_1436800
uniprot id: Q8IL98
names: Similarity
messages: Belongs to the peptidase S14 family.

36329:PF3D7 1443600
gene id: 36329:PF3D7_1443600
uniprot id: Q8IL35
names: Similarity
messages: Belongs to the TUBGCP family.

36329:PF3D7 1436600
gene id: 36329:PF3D7_1436600
uniprot id: Q8I719
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by cGMP (PubMed:12068803, PubMed:12817987, PubMed:26149123, PubMed:29251493, PubMed:25646845, PubMed:31239348). Not activated by cAMP (PubMed:12068803, PubMed:12817987). cGMP binding allosterically triggers a conformational change at the alpha C-helix of cGMP-binding domain 4, which bridges the regulatory and catalytic domains, causing the capping triad, composed of Arg-484, Gln-532 and Asp-533, to form and stabilize the active conformation (PubMed:29251493, PubMed:25646845). The cGMP-binding domains acts cooperatively to activate PKG (PubMed:29251493, PubMed:12817987).
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Expressed during the parasite blood stage, expression is low at the ring stage and in early trophozoites, then increases during the parasite maturation to peak at the late schizont stage (at protein level) (PubMed:31239348, PubMed:19915077, PubMed:23139764, PubMed:12068803). Expression is low in gametocytes (at protein level) (PubMed:23139764).
messages: Monomer.
messages: Serine/threonine protein kinase which acts as a downstream effector of the second messenger cGMP (PubMed:12068803, PubMed:12817987, PubMed:26149123). Controls the release of Ca(2+) from intracellular stores by regulating phosphoinositide biosynthesis (PubMed:24594931). Ca(2+) signals are essential for merozoite and sporozoite invasion and egress from host hepatocytes and erythrocytes, and, in the mosquito vector, for gametocyte activation, and ookinete and sporozoite motility (PubMed:24594931). During the host liver stage, regulates the initial invasion of host hepatocytes by sporozoites by regulating sporozoite motility and microneme exocytosis (By similarity). Following parasite development in the hepatocytes, required for the release of merosomes, a vesicle containing the mature merozoites (By similarity). During the asexual blood stage, required for the progression from schizont to the ring stage following merozoite invasion of host erythrocytes and for merozoite egress (PubMed:19915077, PubMed:26149123, PubMed:25646845). Regulates merozoite egress by promoting the release of exonemes and micronemes which contain proteins essential for egress (PubMed:23675297). Phosphorylates CDPK1 predominantly at the late schizont stage; phosphorylation at 'Ser-64' regulates CDPK1 protein-protein interaction and phosphorylation at 'Thr-231' may regulate CDPK1 kinase activity (PubMed:26149123). Phosphorylates MyoA at 'Ser-19' (PubMed:26149123). In the mosquito vector, required for the initiation of gametogenesis induced by xanthurenic acid, specifically the gametocyte differentiation from the crescent-shaped form to the spherical form (PubMed:18532880). Required for the gliding motility of ookinetes to reach and penetrate the midgut epithelium by promoting Ca(2+)-mediated activation of CDPK1 and CDPK4 (By similarity). Also required for microneme secretion in ookinete by promoting Ca(2+)-mediated activation of CDPK3 (By similarity).
messages: The autoinhibitory segment (AIS) interacts with the active site and inhibits catalytic activity.
messages: The cNMP-binding domains 1, 2 and 4 bind preferentially cGMP (PubMed:25646845). The cNMP-binding domain 4 binds cGMP with the highest affinity and is highly selective for cGMP (PubMed:29251493, PubMed:25646845, PubMed:31239348). The cNMP-binding domain 3 does not bind cGMP but is required for cGMP-dependent catalytic activity (PubMed:12817987). The cNMP-binding domains 1, 2 and 4 can bind cAMP but with less affinity (PubMed:25646845).

36329:PF3D7 0407700
gene id: 36329:PF3D7_0407700
uniprot id: Q9U0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

36329:PF3D7 0821500
gene id: 36329:PF3D7_0821500
uniprot id: Q8IB49
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

36329:PF3D7 0612100
gene id: 36329:PF3D7_0612100
uniprot id: C6KSW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

36329:PF3D7 1133400
gene id: 36329:PF3D7_1133400
uniprot id: Q7KQK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apicomplexan parasites AMA1 family.
messages: Involved in parasite invasion of erythrocytes.
messages: Membrane

36329:PF3D7 1314900
gene id: 36329:PF3D7_1314900
uniprot id: Q8IEG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

36329:PF3D7 0310700
gene id: 36329:PF3D7_0310700
uniprot id: O77358
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

36329:PF3D7 1457500
gene id: 36329:PF3D7_1457500
uniprot id: Q8IKQ5
names: Similarity
messages: Belongs to the AAA ATPase family.

36329:PF3D7 1227200
gene id: 36329:PF3D7_1227200
uniprot id: Q8I5E6
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0317300
gene id: 36329:PF3D7_0317300
uniprot id: O77384
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0503400
gene id: 36329:PF3D7_0503400
uniprot id: Q8I467
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin-binding proteins ADF family.
messages: Cytoplasm
messages: Interacts with monomeric actin, does not bind to actin polymers.
messages: Not involved in actin polymerisation, instead functions to stimulate nucleotide exchange on monomeric actin and influence turnover of the small amount of cytosolic actin microfilaments. Essential for erythrocytic schizogony (By similarity).
messages: cytoskeleton

36329:PF3D7 0719200
gene id: 36329:PF3D7_0719200
uniprot id: C0H4N8
names: Similarity
messages: Belongs to the protein kinase superfamily.

36329:PF3D7 0527100
gene id: 36329:PF3D7_0527100
uniprot id: Q8I3J4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

36329:PF3D7 1233300
gene id: 36329:PF3D7_1233300
uniprot id: Q8I589
names: Biotechnology
names: Similarity
messages: Belongs to the PPR family.
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1120600
gene id: 36329:PF3D7_1120600
uniprot id: Q8IIG1
names: Biotechnology
names: Developmental Stage
names: Subcellular Location Annotation
messages: Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0323700
gene id: 36329:PF3D7_0323700
uniprot id: O97303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

36329:PF3D7 0506900
gene id: 36329:PF3D7_0506900
uniprot id: Q8I433
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

36329:PF3D7 0913900
gene id: 36329:PF3D7_0913900
uniprot id: Q8I313
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

36329:PF3D7 0922700
gene id: 36329:PF3D7_0922700
uniprot id: Q8I2S9
names: Similarity
messages: Belongs to the PRP18 family.

36329:PF3D7 1140100
gene id: 36329:PF3D7_1140100
uniprot id: Q8IHW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

36329:PF3D7 1412500
gene id: 36329:PF3D7_1412500
uniprot id: Q8ILW9
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ACT1 and ACT2 differ in their polymerization, filament stability and helical structure. Unlike mammalian actin, Apicomplexa actins do not form long and stable filaments.
messages: ATP hydrolysis occurs in the polymeric state. Unlike for mammalian actin, ATP hydrolysis occurs also in the monomeric form and the release of inorganic phosphate (Pi) is more efficient.
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm. Polymerizes into longer and more stable actin filaments compared to ACT1/actin-1. Has ATPase activity. ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi. ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin. Plays an essential role in male gametocyte development in the mosquito midgut, functioning in several processes including male gametocyte egress from host erythrocytes, formation of a beating flagellum and relocalization of ACT1/actin-1 to the cytoplasm. On the basal side of the mosquito midgut epithelium, required for the development of ookinetes into sporogonic oocysts.
messages: Belongs to the actin family.
messages: Cytoplasm
messages: Monomer (G-actin). Oligomer (F-actin). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Unlike for mammalian monomeric actin, monomeric actin is able to induce oligomerization with ATP or ADP. Mg(2+), which is used to coordinate ATP, is required for polymerization.
messages: cytoskeleton

36329:PF3D7 0629100
gene id: 36329:PF3D7_0629100
uniprot id: C6KTC6
names: Similarity
messages: Belongs to the NAPRTase family.

36329:PF3D7 1007700
gene id: 36329:PF3D7_1007700
uniprot id: Q8IJW6
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1365500
gene id: 36329:PF3D7_1365500
uniprot id: Q8I6T0
names: Similarity
messages: Belongs to the GcvT family.

36329:PF3D7 0827700
gene id: 36329:PF3D7_0827700
uniprot id: Q8IBA9
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0106900
gene id: 36329:PF3D7_0106900
uniprot id: Q8I273
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.

36329:PF3D7 1106800
gene id: 36329:PF3D7_1106800
uniprot id: Q8IIT5
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the kinase superfamily, contains an asparagine residue at the position of the canonical catalytic aspartic acid and does not have kinase activity (PubMed:31148576). However, can bind ATP (PubMed:31148576).
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Host cell membrane
messages: Host cytoplasm
messages: Interacts (via RVxF motif 1 and/or 2) with phosphatase PP1C (PubMed:31148576). May interact (via SAM domain) with SERA5 (via C-terminus) (PubMed:31148576).
messages: Parasitophorous vacuole
messages: The protein kinase domain is predicted to be catalytically inactive (By similarity). There is a second N-terminal lobe-like kinase domain at residues 830-1095 that contains functional ATP binding sites (PubMed:31148576).
messages: host cytoskeleton

36329:PF3D7 1332600
gene id: 36329:PF3D7_1332600
uniprot id: Q8IE02
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apurinic/apyrimidinic (AP) endonuclease activity is enhanced with increasing concentrations of Mn(2+), while Zn(2+) initially enhances activity but subsequently inhibits activity in a concentration-dependent manner (PubMed:31386260). Co(2+) inhibits apurinic/apyrimidinic (AP) endonuclease activity at concentrations greater than 2.5 mM (PubMed:31386260).
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 2 Zn(2+) and 1 Mn(2+) ions.
messages: Expressed during the asexual blood stage (at protein level).
messages: May be proteolytically cleaved into a 59 kDa form.
messages: Mitochondrion
messages: Plays a role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress (PubMed:31386260). Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) with a preference for C as opposite base (PubMed:31386260). Has 3'-phosphatase activity; removes 3'-phosphate from blunt-end, recessed, and gapped DNA templates and thus, removes 3'-blocks for DNA polymerase activity during BER (PubMed:31386260). Lacks 3'-5' exonuclease activity and does not cleave damaged bases by nucleotide incision repair (NIR) (PubMed:31386260).

36329:PF3D7 0320500
gene id: 36329:PF3D7_0320500
uniprot id: O97284
names: Similarity
messages: Belongs to the isochorismatase family.

36329:PF3D7 1251300
gene id: 36329:PF3D7_1251300
uniprot id: Q8I4S1
names: Activity Regulation
names: Biotechnology
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate kinase family.
messages: Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP (PubMed:18477629, PubMed:19126267, PubMed:31934749, PubMed:20353400). Can also phosphorylate dGMP and to a lesser extent GMP, dUMP and dIMP (PubMed:18477629, PubMed:19126267, PubMed:31934749, PubMed:20353400). Can use either ATP or dATP as phosphate donors in presence of Mg(2+) (PubMed:18477629).
messages: Homodimer (PubMed:18477629, PubMed:19126267, PubMed:31934749). Binds two dTMP molecules per dimer (PubMed:31934749). Binds only one dTGP molecule per dimer (PubMed:31934749).
messages: Inhibited by deoxyguanosine (dG), deoxythymidine (dT) and azidothymidine (AZT).
messages: Phosphorylates AZT monophosphate (AZT-MP) more efficiently than human DTYMK/TMPK. The conversion of AZT MP into AZT diphosphate (AZT-DP) by the human enzyme is a crucial step in the production of the active anti-HIV drug AZT triphosphate (AZT-TP).

36329:PF3D7 0625100
gene id: 36329:PF3D7_0625100
uniprot id: C6KT87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

36329:PF3D7 1412800
gene id: 36329:PF3D7_1412800
uniprot id: Q8ILW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity). Myristoylates adenylate kinase AK2 (By similarity). During the asexual blood stage, may myristoylate proteins such as ARO, CDPK1 and GAP45 (PubMed:34695132). Probably by mediating protein myristoylation, plays a role in the assembly of the inner membrane complex during the early stages of schizogony and in the formation of rhoptries in the late stages and thus merozoite egress (PubMed:34695132).
messages: Belongs to the NMT family.
messages: Cytoplasm
messages: Heterodimer composed of NMT and AK2; AK2 myristoylation stabilizes the complex.

36329:PF3D7 1209600
gene id: 36329:PF3D7_1209600
uniprot id: Q8I5V3
names: Similarity
messages: Belongs to the HMBS family.

36329:PF3D7 0522300
gene id: 36329:PF3D7_0522300
uniprot id: C0H4F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 0206200
gene id: 36329:PF3D7_0206200
uniprot id: O96156
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

36329:PF3D7 1471400
gene id: 36329:PF3D7_1471400
uniprot id: Q8IKC5
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

36329:PF3D7 1458700
gene id: 36329:PF3D7_1458700
uniprot id: Q8IKP4
names: Similarity
messages: Belongs to the EXO5 family.

36329:PF3D7 0404900
gene id: 36329:PF3D7_0404900
uniprot id: Q8I1Y0
names: Developmental Stage
names: Disruption Phenotype
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell surface
messages: Does not have erythrocyte-receptor-binding ability.
messages: Heterodimer; heterodimerizes with PF12. May form an antiparallel heterodimer with PF12.
messages: No visible phenotype. Parasites grow at normal rates in vitro.
messages: Processed into a soluble form.
messages: Specifically present in asexual blood stage parasites. First detected in the trophozoite stage, 30-40 hours post-invasion (HPI) and the proteins reaches peak expression in schizont stage, 40-48 HPI.

36329:PF3D7 1242800
gene id: 36329:PF3D7_1242800
uniprot id: Q8I501
names: Similarity
messages: Belongs to the Rab GDI family.

36329:PF3D7 0926400
gene id: 36329:PF3D7_0926400
uniprot id: C0H564
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1452700
gene id: 36329:PF3D7_1452700
uniprot id: Q8IKU9
names: Similarity
messages: Belongs to the Luc7 family.

36329:PF3D7 1311900
gene id: 36329:PF3D7_1311900
uniprot id: Q76NM6
names: Activity Regulation
names: Biotechnology
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity).
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:10915784). During the trophozoite stage, involved in the acidification of the extracellular space next to the cell membrane (PubMed:10915784).
messages: Cell membrane
messages: Expressed during the asexual blood stage, including in trophozoites (at protein level).
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d and subunit e (By similarity).
messages: Vacuole
messages: Vesicle

36329:PF3D7 1321800
gene id: 36329:PF3D7_1321800
uniprot id: Q8IE98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

36329:PF3D7 0320300
gene id: 36329:PF3D7_0320300
uniprot id: O97282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

36329:PF3D7 1347800
gene id: 36329:PF3D7_1347800
uniprot id: A0A5K1K981
names: Similarity
messages: Belongs to the DNAAF1 family.

36329:PF3D7 0321200
gene id: 36329:PF3D7_0321200
uniprot id: O97321
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0603500
gene id: 36329:PF3D7_0603500
uniprot id: C6KSN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

36329:PF3D7 1467400
gene id: 36329:PF3D7_1467400
uniprot id: Q8IKG3
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

36329:PF3D7 0623300
gene id: 36329:PF3D7_0623300
uniprot id: C6KT69
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

36329:PF3D7 0531200
gene id: 36329:PF3D7_0531200
uniprot id: Q8I3F6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

36329:PF3D7 0726900
gene id: 36329:PF3D7_0726900
uniprot id: Q8IBI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

36329:PF3D7 0804800
gene id: 36329:PF3D7_0804800
uniprot id: Q8I6S4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

36329:PF3D7 1012000
gene id: 36329:PF3D7_1012000
uniprot id: Q8IJS5
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 1456800
gene id: 36329:PF3D7_1456800
uniprot id: Q8IKR1
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1469700
gene id: 36329:PF3D7_1469700
uniprot id: Q8IKE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

36329:PF3D7 1342600
gene id: 36329:PF3D7_1342600
uniprot id: Q8IDR3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cell membrane
messages: Expressed during the parasite blood stage (at protein level).
messages: Interacts with ACT1.
messages: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
messages: This protein differs from the typical myosin heavy chain structure in having head and tail domains but no discernible neck domain.

36329:PF3D7 0204900
gene id: 36329:PF3D7_0204900
uniprot id: O96145
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

36329:PF3D7 1142400
gene id: 36329:PF3D7_1142400
uniprot id: Q8IHU1
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

36329:PF3D7 1340300
gene id: 36329:PF3D7_1340300
uniprot id: Q8IDT3
names: Similarity
messages: Belongs to the NOC2 family.

36329:PF3D7 0316500
gene id: 36329:PF3D7_0316500
uniprot id: O77390
names: Similarity
messages: Belongs to the NUF2 family.

36329:PF3D7 0910100
gene id: 36329:PF3D7_0910100
uniprot id: C0H530
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

36329:PF3D7 1465700
gene id: 36329:PF3D7_1465700
uniprot id: Q8IKI0
names: Similarity
messages: Belongs to the peptidase A1 family.

36329:PF3D7 1136900
gene id: 36329:PF3D7_1136900
uniprot id: Q8IHZ5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activation may be calcium-dependent (PubMed:16879884). Inhibited by the non-covalent interaction with the cleaved propeptide (PubMed:16879884, PubMed:19214190).
messages: Belongs to the peptidase S8 family.
messages: Cell membrane
messages: Proteolytically cleaved at the N-terminus to generate a 74kDa intermediate which is further processed into a 72kDa form (PubMed:23834729). The first maturation cleavage is autocatalytic, occurs in the ER and is necessary for the subsequent SUB2 trafficking to the microneme (PubMed:23834729). The second cleavage may be mediated by PMX/plasmepsin X (PubMed:32109369).
messages: Serine protease which plays an essential role in the shedding of AMA1, MSP1 and MSP7 from the surface of the invading merozoite; this step is essential for productive invasion and the release of the adhesion between the erythrocyte and the merozoite (PubMed:16879884, PubMed:19214190). May cleave TRAMP/PTTRAMP, thereby shedding TRAMP from the merozoite surface during erythrocyte invasion (PubMed:16879884).
messages: The cytoplasmic domain is required for the correct redistribution at the merozoite surface and posterior capping but is dispensable for its progression through the secretory pathway.
messages: The propeptide domain acts as an intramolecular chaperone for the folding of the catalytic domain (By similarity). Also acts as an inhibitor of the catalytic domain thereby regulating SUB2 activity during secretion (PubMed:16879884, PubMed:19214190).
messages: The transmembrane domain is required for SUB2 progression through the secretory pathway.
messages: microneme membrane

36329:PF3D7 1417800
gene id: 36329:PF3D7_1417800
uniprot id: Q8ILR7
names: Similarity
messages: Belongs to the MCM family.

36329:PF3D7 1347200
gene id: 36329:PF3D7_1347200
uniprot id: Q8IDM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

36329:PF3D7 1147500
gene id: 36329:PF3D7_1147500
uniprot id: Q8IHP6
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

36329:PF3D7 0618600
gene id: 36329:PF3D7_0618600
uniprot id: C6KT26
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 0825500
gene id: 36329:PF3D7_0825500
uniprot id: Q8IB88
names: Similarity
messages: Belongs to the KRI1 family.

36329:PF3D7 0808400
gene id: 36329:PF3D7_0808400
uniprot id: C0H4T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane

36329:PF3D7 0727200
gene id: 36329:PF3D7_0727200
uniprot id: Q8IBI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm

36329:PF3D7 0106700
gene id: 36329:PF3D7_0106700
uniprot id: Q8I275
names: Subcellular Location Annotation
messages: nucleolus

36329:PF3D7 0618500
gene id: 36329:PF3D7_0618500
uniprot id: C6KT25
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

36329:PF3D7 1335500
gene id: 36329:PF3D7_1335500
uniprot id: C0H5F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS2/PSF2 family.
messages: Nucleus

36329:PF3D7 0416300
gene id: 36329:PF3D7_0416300
uniprot id: Q8I1S4
names: Similarity
messages: Belongs to the MCM family.

36329:PF3D7 0614800
gene id: 36329:PF3D7_0614800
uniprot id: C6KSY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Mitochondrion
messages: Nucleus

36329:PF3D7 1329100
gene id: 36329:PF3D7_1329100
uniprot id: Q8IE50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

36329:PF3D7 1134700
gene id: 36329:PF3D7_1134700
uniprot id: Q8II17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: apicoplast

36329:PF3D7 1431700
gene id: 36329:PF3D7_1431700
uniprot id: Q8ILE8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

36329:PF3D7 0217100
gene id: 36329:PF3D7_0217100
uniprot id: O96252
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

36329:PF3D7 1412300
gene id: 36329:PF3D7_1412300
uniprot id: Q8ILX1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

36329:PF3D7 0612600
gene id: 36329:PF3D7_0612600
uniprot id: C6KSW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

36329:PF3D7 0818200
gene id: 36329:PF3D7_0818200
uniprot id: C0H4V6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein which binds to its partners, usually via a phosphoserine or phosphothreonine motif (PubMed:23308157, PubMed:32484216, PubMed:32817103). Binding generally results in the modulation of the activity and/or cellular localization of the binding partner (Probable). Via its interaction with CDPK1 and PKAr, involved in merozoite microneme secretion and thus in merozoite invasion of host erythrocytes (PubMed:32817103).
messages: Belongs to the 14-3-3 family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed during parasite asexual blood stages, at the ring, trophozoite and schizont stages and in free merozoites (at protein level).
messages: Homodimer (Probable). Forms a complex composed of CDPK1, PKA regulatory subunit PKAr and 14-3-3I; the complex is formed in merozoites in response to low extracellular level of K(+) and may play a role in microneme secretion (PubMed:32817103). Interacts with CDPK1 (when phosphorylated) in a Ca(2+)-independent manner; the interaction does not regulate CDPK1 catalytic activity but is required for merozoite invasion of host erythrocytes (PubMed:32484216, PubMed:32817103). Interacts with PKA regulatory subunit PKAr (when phosphorylated) in a Ca(2+)-dependent manner (PubMed:32817103). Interacts with histone H3 (when phosphorylated at 'Ser-28' or when phosphorylated at 'Ser-28' and 'Ser-32') (PubMed:23308157).
messages: Nucleus

36329:PF3D7 1239900
gene id: 36329:PF3D7_1239900
uniprot id: Q8I524
names: Similarity
messages: Belongs to the VPS16 family.

36329:PF3D7 1144300
gene id: 36329:PF3D7_1144300
uniprot id: C6S3G4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.

36329:PF3D7 0106100
gene id: 36329:PF3D7_0106100
uniprot id: Q8I280
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

36329:PF3D7 0623600
gene id: 36329:PF3D7_0623600
uniprot id: C6KT72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

36329:PF3D7 0310600.1
gene id: 36329:PF3D7_0310600.1
uniprot id: Q9NFE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

36329:PF3D7 0908700
gene id: 36329:PF3D7_0908700
uniprot id: Q8I0W4
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

36329:PF3D7 0924700
gene id: 36329:PF3D7_0924700
uniprot id: Q8I2R0
names: Similarity
messages: Belongs to the SF3A3 family.

36329:PF3D7 1124700
gene id: 36329:PF3D7_1124700
uniprot id: Q8IIB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

36329:PF3D7 0629800
gene id: 36329:PF3D7_0629800
uniprot id: C6KTD3
names: Similarity
messages: Belongs to the cullin family.

36329:PF3D7 0932600
gene id: 36329:PF3D7_0932600
uniprot id: Q8I2J0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

36329:PF3D7 1362300
gene id: 36329:PF3D7_1362300
uniprot id: Q8ID84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0206800
gene id: 36329:PF3D7_0206800
uniprot id: P50498
names: Biotechnology
names: Developmental Stage
names: Domain
names: Function
names: Polymorphism
names: Subcellular Location Annotation
messages: Cell membrane
messages: Expressed during the asexual blood stage, including at the schizont stage and in free merozoites (at protein level).
messages: May play a role in the merozoite attachment to the erythrocyte.
messages: Potential candidate for the development of parasite blood stage vaccines (PubMed:19428875, PubMed:28189425). In vivo, induces antibodies capable of inhibiting parasite growth in the host (PubMed:19428875). In vitro, antibodies to MSP2 do not appear to inhibit invasion directly but may function to opsonize merozoites and promote antibody-dependent cellular inhibition mediated by host monocytes (PubMed:19428875, PubMed:24218484). The ability of merozoites to carry antibodies bound to MSP2 into the invaded host erythrocyte without apparent disruption of invasion or growth may represent an adaption of the parasite to render antibodies to the merozoite surface non-functional, thereby contributing to immune evasion (PubMed:24218484).
messages: The N-terminal region appears to be involved in lipid binding.
messages: The sequence varies across Plasmodium strains (PubMed:2181307). All variants share conserved N- and C-terminal regions; however, they belong to two allelic families, represented by 3D7 strain and FC27 strain sequences respectively, distinguished by tandem repeats and dimorphic flanking sequences within the central region of the protein (PubMed:2181307).

36329:PF3D7 1137300
gene id: 36329:PF3D7_1137300
uniprot id: Q8IHZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

36329:PF3D7 0714100
gene id: 36329:PF3D7_0714100
uniprot id: Q8IBV6
names: Similarity
messages: Belongs to the CFAP91 family.

36329:PF3D7 1007100
gene id: 36329:PF3D7_1007100
uniprot id: C6S3C4
names: Similarity
messages: Belongs to the GAMAD family.

36329:PF3D7 1223900
gene id: 36329:PF3D7_1223900
uniprot id: Q8I5H8
names: Function
names: Subunit
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

36329:PF3D7 1353300
gene id: 36329:PF3D7_1353300
uniprot id: Q8IDG7
names: Biotechnology
names: Subcellular Location Annotation
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0416800
gene id: 36329:PF3D7_0416800
uniprot id: Q8I1S0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

36329:PF3D7 0109850
gene id: 36329:PF3D7_0109850
uniprot id: B9ZSI8
names: Similarity
messages: Belongs to the polyprenol kinase family.

36329:PF3D7 0910900
gene id: 36329:PF3D7_0910900
uniprot id: C0H531
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

36329:PF3D7 1463800
gene id: 36329:PF3D7_1463800
uniprot id: Q8IKJ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

36329:PF3D7 1441200
gene id: 36329:PF3D7_1441200
uniprot id: Q8IL58
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

36329:PF3D7 0909500
gene id: 36329:PF3D7_0909500
uniprot id: Q8I357
names: Similarity
messages: Belongs to the FAM154 family.

36329:PF3D7 1012700
gene id: 36329:PF3D7_1012700
uniprot id: Q8IJR8
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0415600
gene id: 36329:PF3D7_0415600
uniprot id: Q8I1T1
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between GTP and AMP (PubMed:15478799). Has very low activity with UTP, ITP, CTP and IMP and no activity with ATP, GMP, CMP and UMP in vitro (PubMed:15478799).
messages: Inhibited by the dinucleoside pentaphosphate compound P1,P5-di(guanosine-5') pentaphosphate (GP5A).
messages: Mitochondrion
messages: There is a putative zinc finger domain which may bind to iron.

36329:PF3D7 1344800
gene id: 36329:PF3D7_1344800
uniprot id: A0A5K1K910
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

36329:PF3D7 0411300
gene id: 36329:PF3D7_0411300
uniprot id: Q9U0H5
names: Similarity
messages: Belongs to the GOLGA6 family.

36329:PF3D7 1015700.1
gene id: 36329:PF3D7_1015700.1
uniprot id: C6S3C6
names: Similarity
messages: Belongs to the TBCC family.

36329:PF3D7 0910500
gene id: 36329:PF3D7_0910500
uniprot id: Q8I347
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

36329:PF3D7 0208900
gene id: 36329:PF3D7_0208900
uniprot id: O96175
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell surface
messages: In P.berghei, dispensable for male gamete attachment to erythrocytes and the formation of exflagellation centers.
messages: Plays an essential role in male gamete fertility (By similarity). Required for the binding to erythrocytes and thus, for the formation of exflagellation centers (By similarity).
messages: Specifically presents on the surface of stage V male gametocytes (at protein level) (PubMed:12106866, PubMed:30297725). Not expressed in gametes or asexual parasites (PubMed:12106866). Expression peaks in stage III/IV gametocytes, then sharply declines in gametes (PubMed:12106866).

36329:PF3D7 0630300
gene id: 36329:PF3D7_0630300
uniprot id: C6KTD8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

36329:PF3D7 1429200
gene id: 36329:PF3D7_1429200
uniprot id: Q8ILH2
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1245100
gene id: 36329:PF3D7_1245100
uniprot id: Q8I4Y0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

36329:PF3D7 0301700
gene id: 36329:PF3D7_0301700
uniprot id: O97336
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: At the asexual blood stage, causes an accumulation of vesicles at the Maurer's clefts (PubMed:35930605). Aberrant knob morphology and distribution; knobs are fewer and larger (PubMed:35930605). EMP1 delivery to the Maurer's clefts is normal; however, EMP1 delivery to the host erythrocyte cell surface is abolished (PubMed:35930605).
messages: During the asexual blood stage, plays an essential role in the recruitment and/or formation of EMP1-containing vesicles at the Maurer's clefts and their subsequent transfer to the host erythrocyte cell membrane.
messages: Expressed during the asexual blood stage, including rings and trophozoites (at protein level).
messages: Host cytoplasm
messages: May interact with MESA (PubMed:35930605). May interact with J-dot compartment protein PF3D7_0801000 (PubMed:35930605).
messages: Membrane
messages: The P.falciparum Export Element (PEXEL) motif, also known as the vacuolar transport signal (VTS), is a pentameric sequence (RxLxE/Q/D) required for the translocation of proteins across the parasitophorous vacuole membrane (Probable). In the endoplasmic reticulum, the motif is cleaved after the leucine residue and the N-terminus is N-acetylated (By similarity).
messages: Vesicle

36329:PF3D7 0308500
gene id: 36329:PF3D7_0308500
uniprot id: O97256
names: Similarity
messages: Belongs to the AHA1 family.

36329:PF3D7 0209000
gene id: 36329:PF3D7_0209000
uniprot id: P68874
names: Biotechnology
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell surface
messages: Gametocyte surface protein required for male/female gamete fusion. Also required for male gamete exflagellation and interaction with host erythrocytes.
messages: Heterodimer; heterodimerizes with PF45/48.
messages: May be processed into a 310 kDa form as the parasite emerges from the host erythrocytes.
messages: Promising transmission-blocking vaccine candidate: targeting the protein would prevents transmission of the parasite decreasing the malaria burden (PubMed:32709983, PubMed:33741942). The LMIV230-01 transmission-blocking antibody against the 6-Cys domain 1 also binds to the heterologous P.falciparum Malian isolate 20-2217-0 which carries a 'Ser-605' polymorphism and to the heterologous St Lucia strain which carries 'Ser-605' and 'Asn-661' polymorphisms (PubMed:33741942).
messages: Specifically expressed in gametocytes and gametes (at protein level).

36329:PF3D7 1422900
gene id: 36329:PF3D7_1422900
uniprot id: Q8ILM3
names: Similarity
messages: Belongs to the 14-3-3 family.

36329:PF3D7 0217300
gene id: 36329:PF3D7_0217300
uniprot id: O96254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

36329:PF3D7 1213700
gene id: 36329:PF3D7_1213700
uniprot id: Q8I5R8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

36329:PF3D7 1402300
gene id: 36329:PF3D7_1402300
uniprot id: Q8IM66
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

36329:PF3D7 1247300
gene id: 36329:PF3D7_1247300
uniprot id: Q8I4V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

36329:PF3D7 0628100
gene id: 36329:PF3D7_0628100
uniprot id: C6KTB7
names: Biotechnology
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
messages: Putative E3 ubiquitin-protein ligase.

36329:PF3D7 0905800
gene id: 36329:PF3D7_0905800
uniprot id: Q8I391
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0509000
gene id: 36329:PF3D7_0509000
uniprot id: Q8I0X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

36329:PF3D7 1242700
gene id: 36329:PF3D7_1242700
uniprot id: Q8I502
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

36329:PF3D7 1455400
gene id: 36329:PF3D7_1455400
uniprot id: Q8IKS4
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1311800
gene id: 36329:PF3D7_1311800
uniprot id: Q8IEK1
names: Similarity
messages: Belongs to the peptidase M1 family.

36329:PF3D7 1246600
gene id: 36329:PF3D7_1246600
uniprot id: Q8I4W6
names: Similarity
messages: Belongs to the CWC26 family.

36329:PF3D7 0204700
gene id: 36329:PF3D7_0204700
uniprot id: Q7KWJ5
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

36329:PF3D7 1015100
gene id: 36329:PF3D7_1015100
uniprot id: Q8IJP4
names: Similarity
messages: Belongs to the CWC16 family.

36329:PF3D7 1406400
gene id: 36329:PF3D7_1406400
uniprot id: Q8IM30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPR family. P subfamily.
messages: Binds to apicoplast RNA transcripts, preferentially to the motif UUAU, and protects RNA transcripts from degradation by ribonuclease.
messages: Homodimer.
messages: apicoplast

36329:PF3D7 0106400
gene id: 36329:PF3D7_0106400
uniprot id: Q8I278
names: Similarity
messages: Belongs to the TSR2 family.

36329:PF3D7 0911700
gene id: 36329:PF3D7_0911700
uniprot id: Q8I335
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity).

36329:PF3D7 1322100
gene id: 36329:PF3D7_1322100
uniprot id: Q8IE95
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Chromosome
messages: Highly expressed in early trophozoite stages. Expression is then reduced in late trophozoites and elevated again in schizonts.
messages: Histone methyltransferase that specifically represses expression of the surface antigen-coding var genes by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3) on var genes. SETVS-dependent H3K36me3 is specifically involved in var genes silencing, a central step malaria pathogenesis: each parasite contains 60 distinct var genes that each code for a different PfEMP1 protein. During infection, the clonal parasite population expresses only 1 gene at a time, while the 59 other var genes are silenced. The parasite then switches to the expression of a new variant antigen as an immune-evasion mechanism to avoid the host antibody response. Represses expression of both var mRNA and antisense long non-coding RNA.
messages: Leads to expression of all var genes in the ring stage.
messages: Nucleus
messages: Parasites lacking SETVS could be used as an antimalarial vaccine because of its ability to express all PfEMP1 proteins, to which the antibody would provide efficient protective immunity against malaria.

36329:PF3D7 0722400
gene id: 36329:PF3D7_0722400
uniprot id: Q8IBM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

36329:PF3D7 1413800
gene id: 36329:PF3D7_1413800
uniprot id: Q8ILV7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

36329:PF3D7 1204300
gene id: 36329:PF3D7_1204300
uniprot id: Q8I603
names: Function
names: PTM
names: Similarity
messages: Belongs to the eIF-5A family.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

36329:PF3D7 1404800
gene id: 36329:PF3D7_1404800
uniprot id: Q8IM46
names: Biotechnology
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 0706700
gene id: 36329:PF3D7_0706700
uniprot id: C0H4L8
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1318100
gene id: 36329:PF3D7_1318100
uniprot id: Q8IED5
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2Fe2S plant-type ferredoxin family.
messages: Binds 1 2Fe-2S cluster.
messages: Detected in trophozoite and schizont stages (at protein level).
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions (PubMed:16289098). By transferring electrons to 4-hydroxy-3-methylbut-2-enyl diphosphate reductase LytB/IspH, plays a role in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis (PubMed:16289098).
messages: apicoplast

36329:PF3D7 1443500
gene id: 36329:PF3D7_1443500
uniprot id: Q8IL36
names: Similarity
messages: Belongs to the CAF1 family.

36329:PF3D7 0205900
gene id: 36329:PF3D7_0205900
uniprot id: O96153
names: Similarity
messages: Belongs to the proteasome subunit S2 family.

36329:PF3D7 1456100
gene id: 36329:PF3D7_1456100
uniprot id: Q8IKR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHMT family.
messages: Cytoplasm

36329:PF3D7 0621500
gene id: 36329:PF3D7_0621500
uniprot id: C6KT53
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

36329:PF3D7 0310400
gene id: 36329:PF3D7_0310400
uniprot id: O77361
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1437800
gene id: 36329:PF3D7_1437800
uniprot id: Q7KQM2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Blood stage antigen transported to the erythrocyte surface.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Host membrane
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

36329:PF3D7 1134000
gene id: 36329:PF3D7_1134000
uniprot id: Q8II24
names: Similarity
messages: Belongs to the heat shock protein 70 family.

36329:PF3D7 1312600
gene id: 36329:PF3D7_1312600
uniprot id: Q8IEJ6
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

36329:PF3D7 1006900
gene id: 36329:PF3D7_1006900
uniprot id: Q8IJX2
names: Similarity
messages: Belongs to the DeSI family.

36329:PF3D7 0102900
gene id: 36329:PF3D7_0102900
uniprot id: Q8I2B1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

36329:PF3D7 0816000
gene id: 36329:PF3D7_0816000
uniprot id: Q8IAZ7
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0404400
gene id: 36329:PF3D7_0404400
uniprot id: Q8I1Y5
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Attenuated parasites that cannot commit to infection, even when they encounter with hepatocytes, resulting in continuous traversal of hepatocytes.
messages: Cell membrane
messages: Cell surface
messages: Involved in sporozoite infection of hepatocytes and replication therein.

36329:PF3D7 0815200
gene id: 36329:PF3D7_0815200
uniprot id: Q8IAY9
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 1314500
gene id: 36329:PF3D7_1314500
uniprot id: Q8I6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

36329:PF3D7 1451700
gene id: 36329:PF3D7_1451700
uniprot id: Q8IKV9
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

36329:PF3D7 1324900
gene id: 36329:PF3D7_1324900
uniprot id: Q76NM3
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

36329:PF3D7 0501800
gene id: 36329:PF3D7_0501800
uniprot id: Q8I482
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

36329:PF3D7 1027400
gene id: 36329:PF3D7_1027400
uniprot id: Q8IJC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

36329:PF3D7 0812400
gene id: 36329:PF3D7_0812400
uniprot id: Q8IAW0
names: Similarity
messages: Belongs to the importin alpha family.

36329:PF3D7 0304600
gene id: 36329:PF3D7_0304600
uniprot id: Q7K740
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plasmodium circumsporozoite protein family.
messages: CSP immunodominant B cell epitopes are primarily located in the central repeats (PubMed:29554084). Antibodies against CSP and particularly against the central repeats can neutralize infection at the pre-liver stage and thus makes CSP an attractive candidate for the development of vaccines (PubMed:29554084, PubMed:32150583).
messages: Cell membrane
messages: Cytoplasm
messages: During host cell invasion, proteolytically cleaved at the cell membrane in the region I by a papain-like cysteine protease of parasite origin (By similarity). Cleavage is triggered by the sporozoite contact with highly sulfated heparan sulfate proteoglycans (HSPGs) present on the host hepatocyte cell surface (By similarity). Cleavage exposes the TSP type-1 (TSR) domain and is required for productive invasion of host hepatocytes but not for adhesion to the host cell membrane (By similarity). Cleavage is dispensable for sporozoite development in the oocyst, motility and for traversal of host and vector cells (By similarity).
messages: Essential sporozoite protein (PubMed:29554084, PubMed:32150583). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:29554084, PubMed:32150583). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity).
messages: In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
messages: O-glycosylated; maybe by POFUT2.
messages: The GPI-anchor is essential for cell membrane localization and for sporozoite formation inside the oocyst.
messages: The N-terminus is involved in the initial binding to heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (PubMed:27560376). The N-terminus masks the TSP type-1 (TSR) domain which maintains the sporozoites in a migratory state, enabling them to complete their journey to the salivary gland in the mosquito vector and then to the host liver. The unmasking of the TSP type-1 (TSR) domain when the sporozoite interacts with the host hepatocyte also protects sporozoites from host antibodies (By similarity).
messages: The TSP type-1 (TSR) domain is required for sporozoite development and invasion. CSP has two conformational states, an adhesive conformation in which the TSP type-1 (TSR) domain is exposed and a nonadhesive conformation in which the TSR is masked by the N-terminus. TSR-exposed conformation occurs during sporozoite development in the oocyst in the mosquito vector and during host hepatocyte invasion. TSR-masked conformation occurs during sporozoite migration through the hemolymph to salivary glands in the mosquito vector and in the host dermis.
messages: The sequence of the repeats varies across Plasmodium species and strains.

36329:PF3D7 1415800
gene id: 36329:PF3D7_1415800
uniprot id: Q8ILT8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

36329:PF3D7 1106000
gene id: 36329:PF3D7_1106000
uniprot id: Q8IIU3
names: Similarity
messages: Belongs to the RuvB family.

36329:PF3D7 1346800
gene id: 36329:PF3D7_1346800
uniprot id: Q8IDN0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell surface
messages: Exhibits a high rate of non-synonymous polymorphism is different strains, suggesting that it adapts to different Anopheles vector species.
messages: Expressed only in female gametocytes following emergence from red blood cells.
messages: Mediates evasion of the mosquito innate immune response by suppressing midgut nitration responses that are critical to activate the mosquito complement system. It is unclear whether the protein has a role in passive evasion by making the parasite invisible to the mosquito immune system, acts as a decoy to prevent recognition of another surface protein or anchors the decoy protein. Not required for female fertility.
messages: Reduced parasite survival in the mosquito. Parasites produce normal numbers of oocysts when included in the blood meal of the mosquito vector.

36329:PF3D7 0730200
gene id: 36329:PF3D7_0730200
uniprot id: Q8IBF8
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

36329:PF3D7 0925200
gene id: 36329:PF3D7_0925200
uniprot id: Q8I2Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Probable methyltransferase required to silence rDNA.
messages: nucleolus

36329:PF3D7 1018500
gene id: 36329:PF3D7_1018500
uniprot id: C6S3D1
names: Similarity
messages: Belongs to the PHF5 family.

36329:PF3D7 0524900
gene id: 36329:PF3D7_0524900
uniprot id: Q8I3L6
names: Similarity
messages: Belongs to the TYW1 family.

36329:PF3D7 1202100.1
gene id: 36329:PF3D7_1202100.1
uniprot id: Q8I624
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

36329:PF3D7 1015600
gene id: 36329:PF3D7_1015600
uniprot id: Q8IJN9
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

36329:PF3D7 1205000
gene id: 36329:PF3D7_1205000
uniprot id: Q8I5Z5
names: Biotechnology
names: Subcellular Location Annotation
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1325600
gene id: 36329:PF3D7_1325600
uniprot id: Q8IE63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Mitochondrion outer membrane

36329:PF3D7 0414300
gene id: 36329:PF3D7_0414300
uniprot id: C0H4A3
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1239200
gene id: 36329:PF3D7_1239200
uniprot id: Q8I531
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1124800
gene id: 36329:PF3D7_1124800
uniprot id: Q8IIB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

36329:PF3D7 1012400
gene id: 36329:PF3D7_1012400
uniprot id: Q8IJS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

36329:PF3D7 1409900
gene id: 36329:PF3D7_1409900
uniprot id: Q8ILZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

36329:PF3D7 0927700
gene id: 36329:PF3D7_0927700
uniprot id: Q8I2N2
names: Similarity
messages: Belongs to the PPP phosphatase family.

36329:PF3D7 1467100
gene id: 36329:PF3D7_1467100
uniprot id: Q8IKG6
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

36329:PF3D7 1108000
gene id: 36329:PF3D7_1108000
uniprot id: Q8IIS2
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0514800
gene id: 36329:PF3D7_0514800
uniprot id: Q8I3W0
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

36329:PF3D7 1121000
gene id: 36329:PF3D7_1121000
uniprot id: Q8IIF7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

36329:PF3D7 0516900
gene id: 36329:PF3D7_0516900
uniprot id: Q8I3T9
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

36329:PF3D7 1401100
gene id: 36329:PF3D7_1401100
uniprot id: Q8IM77
names: Biotechnology
names: Subcellular Location Annotation
messages: Membrane
messages: Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

36329:PF3D7 1211100
gene id: 36329:PF3D7_1211100
uniprot id: Q8I5T9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

36329:PF3D7 0109800
gene id: 36329:PF3D7_0109800
uniprot id: Q8I246
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

36329:PF3D7 1304900
gene id: 36329:PF3D7_1304900
uniprot id: Q8IER7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).
messages: Nucleus

36329:PF3D7 0803100
gene id: 36329:PF3D7_0803100
uniprot id: Q8IAN1
names: Subcellular Location Annotation
messages: nucleolus

36329:PF3D7 1029400
gene id: 36329:PF3D7_1029400
uniprot id: Q8IJB1
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

36329:PF3D7 0816300
gene id: 36329:PF3D7_0816300
uniprot id: C0H4U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAP2/GCS1 family.
messages: Cell membrane
messages: Membrane

36329:PF3D7 1248900
gene id: 36329:PF3D7_1248900
uniprot id: Q8I4U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

36329:PF3D7 0502200
gene id: 36329:PF3D7_0502200
uniprot id: Q8I478
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

36329:PF3D7 0726300
gene id: 36329:PF3D7_0726300
uniprot id: Q8IBJ3
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

36329:PF3D7 0305600
gene id: 36329:PF3D7_0305600
uniprot id: O97240
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apurinic/apyrimidinic (AP) endonuclease activity is maximal at low Mg(2+) (0.5-2 mM) with no activity seen at high concentrations (more than 10 mM) (PubMed:33743509). 3'-5' exonuclease activity is maximal in the range of 0.5-2 mM Mg(2+) with activity seen up to 10 mM Mg(2+) (PubMed:33743509).
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Expressed during the asexual blood stage, including trophozoites (at protein level).
messages: May be proteolytically cleaved into a 64 kDa form.
messages: Mitochondrion
messages: Multifunctional protein that plays a central role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress. Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) (PubMed:33743509). Has nucleotide incision repair (NIR) activity; acts on dsDNA with oxidized bases thymine glycol and 5,6-dihydro-2'-deoxyuridine (PubMed:33743509). Has 3'-5' exonuclease; can use dsDNA templates with 3'-OH termini including blunt-end, gapped and mismatched 3'-recessed (PubMed:33743509). Has 3'-phosphatase activity; cleaves 3'-phosphate from blunt, recessed and gapped dsDNA templates, followed by 3'-5' exonuclease activity (PubMed:33743509). Has RNase H-like activity; cleaves RNA on 3'-recessed RNA-DNA duplex (PubMed:33743509). Plays a role in merosome infection of host erythrocytes (By similarity).
messages: Probably binds two magnesium or manganese ions per subunit.

36329:PF3D7 1325100
gene id: 36329:PF3D7_1325100
uniprot id: Q8IE67
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

36329:PF3D7 1434300
gene id: 36329:PF3D7_1434300
uniprot id: Q8ILC1
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90 (PubMed:22005844, PubMed:26267894). Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity (PubMed:31525467).
messages: By heat stress (at protein level).
messages: Cytoplasm
messages: Expressed during the parasite blood stage, in trophozoites (at protein level).
messages: Monomer (PubMed:32343703). Homodimer (PubMed:26267894, PubMed:31525467). Forms a complex composed of HOP and chaperones HSP70 and HSP90; the interaction is stronger in the absence of ATP (PubMed:22005844). Interacts (via TPR 1, 2, 3, 7, 8 and 9 repeats) with HSP70 (via C-terminus); the interaction is direct and is stronger in the absence of ATP (PubMed:26267894). Interacts (via TPR 4, 5 and 6 repeats) with HSP90 (via C-terminus); the interaction is direct (PubMed:26267894).
messages: Showed to form heterodimers (PubMed:26267894, PubMed:31525467). However in a later study, showed to exist predominantly as a monomer (PubMed:32343703).
messages: The TPR repeats form 3 domains; the TPR 1 domain is composed of TPR 1, 2 and 3 repeats, the TPR2A domain of TPR 4, 5 and 6 repeats and TPR2B domain of TPR 7, 8 and 9 repeats.

36329:PF3D7 0906910
gene id: 36329:PF3D7_0906910
uniprot id: Q8I381
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

36329:PF3D7 1424100
gene id: 36329:PF3D7_1424100
uniprot id: Q8ILL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

36329:PF3D7 1116300
gene id: 36329:PF3D7_1116300
uniprot id: Q8IIK3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

36329:PF3D7 1308300
gene id: 36329:PF3D7_1308300
uniprot id: Q8IEN2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

36329:PF3D7 1323200
gene id: 36329:PF3D7_1323200
uniprot id: Q8IE84
names: Similarity
messages: Belongs to the V-ATPase G subunit family.

36329:PF3D7 1456600
gene id: 36329:PF3D7_1456600
uniprot id: Q8IKR3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

36329:PF3D7 0210100.1
gene id: 36329:PF3D7_0210100.1
uniprot id: O96184
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Component of the large ribosomal subunit (PubMed:24913268, PubMed:26432834, PubMed:28288098). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28288098). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).
messages: Cytoplasm
messages: Expressed during the asexual blood stage (at protein level).

36329:PF3D7 1438500
gene id: 36329:PF3D7_1438500
uniprot id: Q8IL83
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1235500
gene id: 36329:PF3D7_1235500
uniprot id: Q8I567
names: Similarity
messages: Belongs to the MT-A70-like family.

36329:PF3D7 1245600
gene id: 36329:PF3D7_1245600
uniprot id: Q8I4X5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

36329:PF3D7 1227100
gene id: 36329:PF3D7_1227100
uniprot id: Q8I5E7
names: Similarity
messages: Belongs to the DEAD box helicase family.

36329:PF3D7 1435300
gene id: 36329:PF3D7_1435300
uniprot id: Q8ILB1
names: Similarity
messages: Belongs to the glutamate synthase family.

36329:PF3D7 0415500
gene id: 36329:PF3D7_0415500
uniprot id: Q8I1T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NCBP2 family.
messages: Nucleus

36329:PF3D7 0826400
gene id: 36329:PF3D7_0826400
uniprot id: Q8IB97
names: Similarity
messages: Belongs to the UPP synthase family.

36329:PF3D7 1205600
gene id: 36329:PF3D7_1205600
uniprot id: Q8I5Y9
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1339500
gene id: 36329:PF3D7_1339500
uniprot id: A0A5K1K9F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

36329:PF3D7 1028300
gene id: 36329:PF3D7_1028300
uniprot id: Q8IJC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: nucleolus

36329:PF3D7 0610900
gene id: 36329:PF3D7_0610900
uniprot id: C6KSV4
names: Similarity
messages: Belongs to the SPT5 family.

36329:PF3D7 1031300
gene id: 36329:PF3D7_1031300
uniprot id: Q8IJ92
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0525900
gene id: 36329:PF3D7_0525900
uniprot id: C0H4G2
names: Similarity
messages: Belongs to the protein kinase superfamily.

36329:PF3D7 1355100
gene id: 36329:PF3D7_1355100
uniprot id: Q8IDF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

36329:PF3D7 0716600
gene id: 36329:PF3D7_0716600
uniprot id: Q8IBT4
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 0728900
gene id: 36329:PF3D7_0728900
uniprot id: C0H4P9
names: Similarity
messages: Belongs to the HTATSF1 family.

36329:PF3D7 0517000
gene id: 36329:PF3D7_0517000
uniprot id: Q8I3T8
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

36329:PF3D7 1118500
gene id: 36329:PF3D7_1118500
uniprot id: Q8III3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

36329:PF3D7 0820500
gene id: 36329:PF3D7_0820500
uniprot id: Q8IB40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 1202400
gene id: 36329:PF3D7_1202400
uniprot id: Q8I621
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

36329:PF3D7 0705000
gene id: 36329:PF3D7_0705000
uniprot id: Q8IC20
names: Similarity
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.

36329:PF3D7 1217100.1
gene id: 36329:PF3D7_1217100.1
uniprot id: Q8I5N7
names: Similarity
messages: Belongs to the TOP6A family.

36329:PF3D7 1340600
gene id: 36329:PF3D7_1340600
uniprot id: A0A5K1K8J0
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1406000
gene id: 36329:PF3D7_1406000
uniprot id: Q8IM34
names: Subcellular Location Annotation
messages: Cytoplasm

36329:PF3D7 1438100
gene id: 36329:PF3D7_1438100
uniprot id: Q8IL86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

36329:PF3D7 0729300
gene id: 36329:PF3D7_0729300
uniprot id: Q8IBG6
names: Similarity
messages: Belongs to the NMD3 family.

36329:PF3D7 0409700
gene id: 36329:PF3D7_0409700
uniprot id: Q8I1W0
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

36329:PF3D7 0207900
gene id: 36329:PF3D7_0207900
uniprot id: O96166
names: Similarity
messages: Belongs to the peptidase C1 family.

36329:PF3D7 1122800
gene id: 36329:PF3D7_1122800
uniprot id: Q8IID5
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

36329:PF3D7 1317200
gene id: 36329:PF3D7_1317200
uniprot id: Q8IEE4
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1321400
gene id: 36329:PF3D7_1321400
uniprot id: Q8IEA0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

36329:PF3D7 1455500
gene id: 36329:PF3D7_1455500
uniprot id: Q8IKS3
names: Subcellular Location Annotation
messages: coated pit

36329:PF3D7 0607500
gene id: 36329:PF3D7_0607500
uniprot id: C6KSS3
names: Similarity
messages: Belongs to the UbiA prenyltransferase family.

36329:PF3D7 1211700
gene id: 36329:PF3D7_1211700
uniprot id: Q8I5T4
names: Similarity
messages: Belongs to the MCM family.

36329:PF3D7 1206200
gene id: 36329:PF3D7_1206200
uniprot id: Q8I5Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

36329:PF3D7 0108400.1
gene id: 36329:PF3D7_0108400.1
uniprot id: B9ZSI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

36329:PF3D7 1005100
gene id: 36329:PF3D7_1005100
uniprot id: Q8IJY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

36329:PF3D7 1110600
gene id: 36329:PF3D7_1110600
uniprot id: Q8IIQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

36329:PF3D7 1108300
gene id: 36329:PF3D7_1108300
uniprot id: C6S3E6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

36329:PF3D7 1011300
gene id: 36329:PF3D7_1011300
uniprot id: Q8IJT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane
messages: Regulates also the sphingolipid metabolism.

36329:PF3D7 0819900
gene id: 36329:PF3D7_0819900
uniprot id: C0H4W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

36329:PF3D7 0917700
gene id: 36329:PF3D7_0917700
uniprot id: Q8I2X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

36329:PF3D7 1027600
gene id: 36329:PF3D7_1027600
uniprot id: C6S3D8
names: Similarity
messages: Belongs to the TOP6A family.

36329:PF3D7 0828500
gene id: 36329:PF3D7_0828500
uniprot id: Q8IBB6
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

36329:PF3D7 1466700
gene id: 36329:PF3D7_1466700
uniprot id: Q8IKH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

36329:PF3D7 1022500
gene id: 36329:PF3D7_1022500
uniprot id: Q8I6U7
names: Similarity
messages: Belongs to the citrate synthase family.

36329:PF3D7 0417300
gene id: 36329:PF3D7_0417300
uniprot id: Q8I1R5
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1238100
gene id: 36329:PF3D7_1238100
uniprot id: Q8I542
names: Function
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

36329:PF3D7 0501900
gene id: 36329:PF3D7_0501900
uniprot id: Q8I481
names: Similarity
messages: Belongs to the TRAPPC13 family.

36329:PF3D7 1355700
gene id: 36329:PF3D7_1355700
uniprot id: Q8IDE5
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 0524000
gene id: 36329:PF3D7_0524000
uniprot id: Q8I3M5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 0708100
gene id: 36329:PF3D7_0708100
uniprot id: Q8IC08
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

36329:PF3D7 1118200
gene id: 36329:PF3D7_1118200
uniprot id: Q8III6
names: Similarity
messages: Belongs to the heat shock protein 90 family.

36329:PF3D7 1103700
gene id: 36329:PF3D7_1103700
uniprot id: Q8IIW5
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Tetramer of two alpha and two beta subunits.

36329:PF3D7 0628600
gene id: 36329:PF3D7_0628600
uniprot id: C6KTC1
names: Subcellular Location Annotation
messages: Nucleus

36329:PF3D7 1409300
gene id: 36329:PF3D7_1409300
uniprot id: Q8IM03
names: Similarity
messages: Belongs to the DDI1 family.

36329:PF3D7 1306400
gene id: 36329:PF3D7_1306400
uniprot id: Q8IEQ1
names: Similarity
messages: Belongs to the AAA ATPase family.

36329:PF3D7 1028400
gene id: 36329:PF3D7_1028400
uniprot id: Q8IJC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

36329:PF3D7 0608800
gene id: 36329:PF3D7_0608800
uniprot id: Q6LFH8
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.
messages: The disulfide bond between Cys-154 and Cys-163 is reduced by TRX1 which increases OAT catalytic activity.
messages: The enzyme has a very narrow substrate specificity and can only catalyze the transamination of alpha-ketoglutarate with ornithine or N-acetylornithine and, to a lesser extent, of glutamate-5-semialdehyde with glutamate and alanine.
messages: Unlike for mammalian OATs, activity is increased by TRX1-mediated reduction of the disulfide bond between Cys-154 and Cys-163 (PubMed:20673832). Binding to TRX1 may also induce conformational changes that facilitate substrate binding (PubMed:20673832).

36329:PF3D7 0314400
gene id: 36329:PF3D7_0314400
uniprot id: O97259
names: Similarity
messages: Belongs to the PPP phosphatase family.

36329:PF3D7 1304500
gene id: 36329:PF3D7_1304500
uniprot id: Q8IES0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

36329:PF3D7 0803800
gene id: 36329:PF3D7_0803800
uniprot id: Q7K6A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

36329:PF3D7 0522600
gene id: 36329:PF3D7_0522600
uniprot id: Q8I3N7
names: Subcellular Location Annotation
messages: Membrane

36329:PF3D7 1225700
gene id: 36329:PF3D7_1225700
uniprot id: Q8I5G0
names: Similarity
messages: Belongs to the VAC14 family.

36329:PF3D7 0411800
gene id: 36329:PF3D7_0411800
uniprot id: Q9U0H2
names: Similarity
messages: Belongs to the GOLGA6 family.

36329:PF3D7 1131100
gene id: 36329:PF3D7_1131100
uniprot id: Q8II53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

36329:PF3D7 0804600
gene id: 36329:PF3D7_0804600
uniprot id: C0H4R3
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

36329:PF3D7 1414000
gene id: 36329:PF3D7_1414000
uniprot id: Q8ILV5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

36329:PF3D7 0818900
gene id: 36329:PF3D7_0818900
uniprot id: Q8IB24
names: Similarity
messages: Belongs to the heat shock protein 70 family.

36329:PF3D7 1020100
gene id: 36329:PF3D7_1020100
uniprot id: C6S3D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

36329:PF3D7 0602400
gene id: 36329:PF3D7_0602400
uniprot id: C6KSM4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.