Belongs to the UDP-glycosyltransferase family.
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
Belongs to the protein kinase superfamily.
Belongs to the complex I subunit 5 family.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Belongs to the complex I 49 kDa subunit family.
Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1.
Belongs to the multicopper oxidase family.
Belongs to the universal ribosomal protein uS7 family.
Belongs to the glycosyltransferase GT106 family.
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Belongs to the eukaryotic ribosomal protein eS19 family.
Belongs to the peroxidase family. Ascorbate peroxidase subfamily.
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.
Belongs to the glutathione peroxidase family.
Belongs to the universal ribosomal protein uS9 family.
Belongs to the purine permeases (TC 2.A.7.14) family.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Belongs to the glycosyltransferase 8 family.
Belongs to the group II decarboxylase family.
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
Binds at least 14 chlorophylls (8 Chl-a and 6 Chl-b) and carotenoids such as lutein and neoxanthin.
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Belongs to the complex I subunit 1 family.
Belongs to the methyltransferase superfamily.
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Belongs to the class-I aminoacyl-tRNA synthetase family.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Belongs to the 3-hydroxybenzoate 6-hydroxylase family.
Belongs to the plant dirigent protein family.
Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.
Belongs to the poly(A) polymerase family.
Associates with the pre-60S ribosomal particle.
Belongs to the universal ribosomal protein uL10 family.
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Belongs to the chaperonin (HSP60) family.
Belongs to the U1 small nuclear ribonucleoprotein C family.
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
Belongs to the RNA polymerase beta' chain family.
Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
Converts zeaxanthin into antheraxanthin and subsequently violaxanthin.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Belongs to the glutaredoxin family. CC-type subfamily.
Belongs to the TALE/KNOX homeobox family.
Belongs to the alkaline ceramidase family.
Belongs to the glycosyl hydrolase 16 family.
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.
Contains at least one intrachain disulfide bond essential for its enzymatic activity.
Belongs to the ABC transporter superfamily. ABCA family. CPR flippase (TC 3.A.1.211) subfamily.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
Belongs to the proteasome subunit S9 family.
Belongs to the methyltransferase superfamily. RRP8 family.
Probable methyltransferase required to silence rDNA.
Belongs to the universal ribosomal protein uL30 family.
Belongs to the DEAD box helicase family.
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
Binds 1 pyruvoyl group covalently per subunit.
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.
Belongs to the NADH dehydrogenase family.
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
Required for vacuolar assembly and vacuolar traffic.
Belongs to the bacterial ribosomal protein bL9 family.
Belongs to the universal ribosomal protein uS4 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
Belongs to the thiolase-like superfamily. Thiolase family.
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
The helical domain is required for self-activation.
Belongs to the HD-ZIP homeobox family. Class IV subfamily.
Belongs to the glycosyltransferase 48 family.
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
Belongs to the expansin family. Expansin A subfamily.
Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).
Lacks conserved residue(s) required for the propagation of feature annotation.
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
Belongs to the GST superfamily. Phi family.
Belongs to the eukaryotic ribosomal protein eL37 family.
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Belongs to the sterol desaturase family.
Contains one covalently linked phytochromobilin chromophore.
Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region.
Belongs to the PC-esterase family. TBL subfamily.
Belongs to the complex I subunit 6 family.
Belongs to the pICln (TC 1.A.47) family.
Belongs to the nucleotide-sugar transporter family. UDP-galactose:UMP antiporter (TC 2.A.7.11) subfamily.
Belongs to the universal ribosomal protein uL15 family.
Belongs to the pseudouridine synthase Pus10 family.
Belongs to the peroxisomal membrane protein PXMP2/4 family.
Belongs to the polysaccharide lyase 1 family.
Binds 1 Ca(2+) ion. Required for its activity.
Component of the 60S subunit of the ribosome.
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
In the N-terminal section; belongs to the ubiquitin family.
Belongs to the universal ribosomal protein uS10 family.
Belongs to the universal ribosomal protein uS13 family.
Belongs to the 'GDXG' lipolytic enzyme family.
The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.
Belongs to the cyclophilin-type PPIase family.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
Belongs to the non-lysosomal glucosylceramidase family.
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
Belongs to the glycosyl hydrolase 85 family.
Belongs to the universal ribosomal protein uS3 family.
Belongs to the sulfotransferase 1 family.
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Belongs to the GatB/GatE family. GatB subfamily.
Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
May be involved in environmental stress response.
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
In the C-terminal section; belongs to the pectinesterase family.
In the N-terminal section; belongs to the PMEI family.
Belongs to the eukaryotic ribosomal protein eL24 family.
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
The active site is a redox-active disulfide bond.
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Belongs to the precorrin methyltransferase family.
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
Belongs to the PYR/PYL/RCAR abscisic acid intracellular receptor family.
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
Glutamate-gated receptor that probably acts as non-selective cation channel.
In the C-terminal section; belongs to the peptidase M41 family.
In the N-terminal section; belongs to the AAA ATPase family.
Belongs to the glycosyltransferase 31 family.
Belongs to the nucleoporin Nup133 family.
Belongs to the inositol monophosphatase superfamily.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
Belongs to the trehalose phosphatase family.
Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.
Belongs to the PIEZO (TC 1.A.75) family.
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Belongs to the 'GDSL' lipolytic enzyme family.
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
Promotes chloroplast protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Belongs to the glycosyltransferase 28 family.
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Belongs to the eukaryotic ribosomal protein eS17 family.
Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes.
Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.
Belongs to the RNA polymerase beta chain family.
Belongs to the LOB domain-containing protein family.
Belongs to the acireductone dioxygenase (ARD) family.
Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Belongs to the argonaute family. Ago subfamily.
Component of the oligosaccharyltransferase (OST) complex.
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Belongs to the cysteine dioxygenase family.
Belongs to the phospholipase D family. C2-PLD subfamily.
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
Functions in brassinosteroid signaling. May function as transcriptional repressor.
Plays an important role in membrane trafficking through the secretory apparatus.
Belongs to the eukaryotic ribosomal protein eL27 family.
Belongs to the phosphatidylethanolamine-binding protein family.
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Belongs to the calcineurin regulatory subunit family.
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
Belongs to the BIG GRAIN 1 (BG1) plant protein family.
Involved in auxin transport. Regulator of the auxin signaling pathway.
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
Belongs to the glycosyltransferase 47 family.
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Plays a role in vesicular protein sorting.
May promote appropriate targeting of ribosome-nascent polypeptide complexes.
Belongs to the bacterial ribosomal protein bS6 family.
The QLQ domain and WRC domain may be involved in protein-protein interaction and DNA-binding, respectively.
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Belongs to the AB hydrolase superfamily. Lipase family.
Belongs to the complex I 30 kDa subunit family.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Belongs to the glutaredoxin family. CPYC subfamily.
Belongs to the fasciclin-like AGP family.
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.
Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
Belongs to the PPR family. PCMP-H subfamily.
Belongs to the zinc-containing alcohol dehydrogenase family.
Belongs to the phosphohexose mutase family.
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily.
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Belongs to the snRNP Sm proteins family.
LSm subunits form a heteromer with a doughnut shape.
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Belongs to the proteasome subunit S3 family.
In the N-terminal section; belongs to the long-chain O-acyltransferase family.
Belongs to the heat shock protein 90 family.
Component of the ribosomal small subunit (SSU) processome.
Involved in nucleolar processing of pre-18S ribosomal RNA.
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Belongs to the lariat debranching enzyme family.
Belongs to the CTL (choline transporter-like) family.
In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
In the N-terminal section; belongs to the leguminous lectin family.
Belongs to the Casparian strip membrane proteins (CASP) family.
Belongs to the Mediator complex subunit 18 family.
Belongs to the complex I 20 kDa subunit family.
Belongs to the glucose-6-phosphate 1-epimerase family.
Belongs to the plant tobamovirus multiplication TOM1 protein family.
Belongs to the small heat shock protein (HSP20) family.
Belongs to the ATPase protein YMF19 family.
This is one of the chains of the nonenzymatic component (CF(0) subunit) of the mitochondrial ATPase complex.
Belongs to the eukaryotic ribosomal protein eS4 family.
Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2.4) family.
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
Belongs to the phage and mitochondrial RNA polymerase family.
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.
Belongs to the RING-type zinc finger family. ATL subfamily.
Belongs to the RBOH (TC 5.B.1.3) family.
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
Belongs to the glycosyl hydrolase 32 family.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Component of the ER membrane protein complex (EMC).
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
Belongs to the CpcT/CpeT biliprotein lyase family.
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Belongs to the nucleotide-sugar transporter family. CMP-Sialate:CMP antiporter (TC 2.A.7.12) subfamily.
Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
Belongs to the 5'(3')-deoxyribonucleotidase family.
Belongs to the GST superfamily. DHAR family.
Belongs to the plant homeotic and developmental regulators ALOG protein family.
Belongs to the class I fructose-bisphosphate aldolase family.
Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.
May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level.
Belongs to the glycosyl hydrolase 14 family.
Belongs to the Mediator complex subunit 20 family.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Belongs to the eukaryotic ribosomal protein eL20 family.
The PPC domain mediates interactions between AHL proteins.
Belongs to the choline monooxygenase family.
Catalyzes the first step of the osmoprotectant glycine betaine synthesis.
Belongs to the small GTPase superfamily. Arf family.
GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
Belongs to the SMC family. RAD50 subfamily.
Belongs to the GTP-binding elongation factor family. LepA subfamily.
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Belongs to the polyprenol kinase family.
Belongs to the heat shock protein 70 family.
Belongs to the eukaryotic ribosomal protein eL15 family.
Belongs to the glycosyl hydrolases 36 family.
Tetramer of 2 alpha and 2 beta subunits.
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
Belongs to the V-ATPase D subunit family.
Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily.
The KHA domain (rich in hydrophobic and acidic residues) present in the C-terminal part is likely to be important for tetramerization.
The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids. The pore-forming region H5 is enclosed by the transmembrane segments S5 and S6 in the Shaker-type (1P/6TM) and contains the GYGD signature motif which seems to be involved in potassium selectivity.
Belongs to the alpha-carbonic anhydrase family.
Belongs to the protein prenyltransferase subunit beta family.
Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Belongs to the eukaryotic ribosomal protein eS27 family.
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response.
Homooligomer. Interacts with ARC5 and FIS1B on peroxisomes.
Involved in peroxisomal proliferation. Promotes peroxisomal duplication, aggregation or elongation without fission.
Acts as a negative regulator of abscisic acid (ABA) response.
Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
Divalent metal cations. Probably Zn(2+).
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
GTPase involved in pre-60S ribosomal subunit maturation.
Belongs to the glycosyl hydrolase 17 family.
Belongs to the DNA2/NAM7 helicase family.
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Belongs to the universal ribosomal protein uS5 family.
Belongs to the universal ribosomal protein uS12 family.
Belongs to the glycosyltransferase group 1 family.
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Belongs to the SMC family. SMC2 subfamily.
Component of a prohibitin multimeric complex in mitochondrial membranes.
Belongs to the complex I 75 kDa subunit family.
Belongs to the casein kinase 2 subunit beta family.
Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Tetramer of two alpha and two beta subunits.
Belongs to the glutamine synthetase family.
Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.
Belongs to the glycosyltransferase 92 family.
Catalyzes the exchange of ADP and ATP across the membrane.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
Belongs to the cyclin family. Cyclin U/P subfamily.
Probably involved in the biogenesis of the COX complex.
Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
Belongs to the prefoldin subunit beta family.
Belongs to the histone deacetylase family. HD Type 1 subfamily.
Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
Belongs to the two pore domain potassium channel (TC 1.A.1.7) family.
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Component of the conserved oligomeric Golgi complex.
Belongs to the succinate/malate CoA ligase beta subunit family.
Heterooctamer of 4 alpha and 4 beta chains.
Belongs to the SIS family. GutQ/KpsF subfamily.
Belongs to the glycosyltransferase 43 family.
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
Belongs to the eukaryotic ribosomal protein eL39 family.
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Belongs to the universal ribosomal protein uL4 family.
Belongs to the Cu-Zn superoxide dismutase family.
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Belongs to the SurE nucleotidase family.
Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
Belongs to the pseudouridine synthase TruB family.
May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Belongs to the glycosyl hydrolase 18 family.
Belongs to the cytochrome c oxidase subunit 2 family.
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Belongs to the PDK/BCKDK protein kinase family.
Belongs to the replication factor A protein 1 family.
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Heterotrimer of RPA1, RPA2 and RPA3 (canonical replication protein A complex).
Belongs to the 11S seed storage protein (globulins) family.
Hexamer; each subunit is composed of an acidic and a basic chain derived from a single precursor and linked by a disulfide bond.
Belongs to the threonine aldolase family.
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
Belongs to the LDH/MDH superfamily. LDH family.
In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Belongs to the eukaryotic ribosomal protein eL18 family.
Belongs to the RBR family. Ariadne subfamily.
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Belongs to the plant rapid alkalinization factor (RALF) family.
Belongs to the eukaryotic ribosomal protein eL8 family.
Common component of the spliceosome and rRNA processing machinery.
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Adaptor protein complexes are heterotetramers composed of two large adaptins (beta-type subunit and alpha-type or delta-type or epsilon-type or gamma-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
Belongs to the adaptor complexes large subunit family.
Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Component of the dolichol-phosphate mannose (DPM) synthase complex.
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.
Belongs to the glycosyl hydrolase 47 family.
Belongs to the EARLY FLOWERING 4 family.
Belongs to the acyl-ACP thioesterase family.
Plays an essential role in chain termination during de novo fatty acid synthesis.
This promotes the activity of RNA polymerase II.
Transcriptional repressor that regulates multiple aspects of plant growth and development.
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Belongs to the small GTPase superfamily. Rho family.
Belongs to the universal ribosomal protein uL5 family.
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
Belongs to the ERCC1/RAD10/SWI10 family.
Belongs to the copper/topaquinone oxidase family.
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
Belongs to the fatty acyl-CoA reductase family.
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
Belongs to the glycosyl hydrolase 28 family.
Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
Belongs to the 2-oxoacid dehydrogenase family.
Belongs to the CDI family. ICK/KRP subfamily.
Belongs to the polyribonucleotide nucleotidyltransferase family.
Belongs to the glycosyltransferase 77 family.
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Belongs to the AP2/ERF transcription factor family. RAV subfamily.
Belongs to the eukaryotic ribosomal protein eL19 family.
Belongs to the proteasome subunit S14 family.
Belongs to the WD repeat WDR12/YTM1 family.
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Belongs to the adenosylhomocysteinase family.
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Belongs to the proteasome subunit S1 family.
Component of the 19S regulatory particle (RP/PA700) base subcomplex of the 26S proteasome. The 26S proteasome is composed of a core protease (CP), known as the 20S proteasome, capped at one or both ends by the 19S regulatory particle (RP/PA700).
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate.
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins.
Belongs to the plant ACBP60 protein family.
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
Mediates the uptake of pyruvate into mitochondria.
May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
Belongs to the cytochrome c oxidase subunit 3 family.
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Belongs to the universal ribosomal protein uL6 family.
Involved in trafficking and recycling of synaptic vesicles.
Belongs to the thioesterase PaaI family.
Belongs to the V-ATPase proteolipid subunit family.
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.
Belongs to the STXBP/unc-18/SEC1 family.
Belongs to the spermidine/spermine synthase family.
Belongs to the non-repetitive/WGA-negative nucleoporin family.
Belongs to the protein kinase superfamily. ADCK protein kinase family.
Belongs to the inositol polyphosphate 5-phosphatase family.
Belongs to the peptidase M28 family. M28B subfamily.
Belongs to the glycosyl hydrolase 100 family.
Invertase that cleaves sucrose into glucose and fructose.
Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.
Belongs to the NFYA/HAP2 subunit family.
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.
Belongs to the DEAD box helicase family. DEAH subfamily.
Belongs to the glycosyl hydrolase 13 family.
Belongs to the acetyltransferase family. GNAT subfamily.
Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.
Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.
Belongs to the peroxisomal targeting signal receptor family.
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Belongs to the DVL/RTFL small polypeptides family.
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Belongs to the nucleosome assembly protein (NAP) family.
Belongs to the helicase family. RecQ subfamily.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Belongs to the thioredoxin family. Plant CITRX-type subfamily.
Belongs to the major facilitator superfamily. phosphate:H(+) symporter (TC 2.A.1.9) family.
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
Belongs to the universal ribosomal protein uL29 family.
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
Belongs to the protein disulfide isomerase family.
Belongs to the universal ribosomal protein uL18 family.
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Mediates 1-deoxy-D-xylulose (DX) phosphorylation in the cytoplasm prior to the translocation of 1-deoxy-D-xylulose 5-phosphate into plastids. Can also phosphorylate D-xylulose (Xyl). Uses preferentially ATP as cosubstrate.
Belongs to the carotenoid oxygenase family.
Belongs to the PEP-utilizing enzyme family.
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
Belongs to the glycosyltransferase 64 family.
Belongs to the YSL (TC 2.A.67.2) family.
Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Belongs to the castor/pollux (TC 1.A.1.23) family.
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Belongs to the DNA polymerase type-B family.
Belongs to the tRNA pseudouridine synthase TruA family.
Probably involved in membrane trafficking.
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.
Belongs to the dus family. Dus3 subfamily.
Belongs to the pseudouridine synthase RluA family.
Belongs to the Rab3-GAP catalytic subunit family.
Belongs to the transketolase family. DXPS subfamily.
Belongs to the TALE/BELL homeobox family.
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.
Belongs to the shaker potassium channel beta subunit family.
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
Belongs to the eIF-2B alpha/beta/delta subunits family.
Belongs to the complex I subunit 4 family.
Belongs to the heme-copper respiratory oxidase family.
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
The jas domain is required for interaction with COI1.
Belongs to the complex I subunit 3 family.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
Belongs to the enoyl-CoA hydratase/isomerase family.
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.
Belongs to the peroxiredoxin family. Prx6 subfamily.
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
Belongs to the glycosyl hydrolase 1 family.
The glycine cleavage system catalyzes the degradation of glycine.
The glycine cleavage system is composed of four proteins: P, T, L and H.
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Belongs to the complex I NDUFA5 subunit family.
Belongs to the universal ribosomal protein uS11 family.
Belongs to the chalcone isomerase family.
Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.
Belongs to the ethylene receptor family.
May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Belongs to the GRAS family. DELLA subfamily.
The DELLA motif is required for its GA-induced degradation.
Transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes.
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
Belongs to the ATPase epsilon chain family.
Belongs to the SWEET sugar transporter family.
Belongs to the Cold-regulated 413 protein family.
Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Belongs to the Mediator complex subunit 21 family.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex.
Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
The PAL motif is required for normal active site conformation.
Belongs to the U2 small nuclear ribonucleoprotein A family.
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
Belongs to the ATPase alpha/beta chains family.
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Belongs to the glycosyltransferase 34 family.
Belongs to the deoxyhypusine synthase family.
Belongs to the F-actin-capping protein alpha subunit family.
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Heterodimer of an alpha and a beta subunit.
Belongs to the type IV zinc-finger family. Class C subfamily.
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Involved in the biosynthesis of phylloquinone (vitamin K1). Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.
Belongs to the selenium-binding protein family.
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Belongs to the ubiquitin-conjugating enzyme family.
Belongs to the DNA mismatch repair MutS family.
Component of the post-replicative DNA mismatch repair system (MMR).
Belongs to the strictosidine synthase family.
Belongs to the pectinacetylesterase family.
Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Belongs to the 2Fe2S plant-type ferredoxin family.
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Belongs to the ribose-phosphate pyrophosphokinase family.
Belongs to the complex I NDUFA13 subunit family.
Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Belongs to the phosphatase 2A regulatory subunit.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Belongs to the glycogen phosphorylase family.
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.
Belongs to the formin-like family. Class-II subfamily.
Belongs to the auxin efflux carrier (TC 2.A.69.1) family.
May act as a component of the auxin efflux carrier.
Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
Belongs to the ATPase protein MI25 family.
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
Monomer. Associates with the 60S ribosomal subunit.
Belongs to the plant ureide permease (TC 2.A.7.19) family.
Belongs to the RNase HII family. Eukaryotic subfamily.
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
Putative transcription activator involved in regulating light control of development.
Belongs to the JARID1 histone demethylase family.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Belongs to the tRNA(His) guanylyltransferase family.
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Belongs to the chloride channel (TC 2.A.49) family.
Belongs to the peptidase M10A family. Matrix metalloproteinases (MMPs) subfamily.
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Probably involved in the defense reaction of plants against pathogens.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
Belongs to the cytidine and deoxycytidylate deaminase family.
Belongs to the TRAPP small subunits family. BET3 subfamily.
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Belongs to the eukaryotic ribosomal protein eS8 family.
Belongs to the GLUTAMINE DUMPER 1 (TC 9.B.60) family.
Belongs to the universal ribosomal protein uL1 family.
Belongs to the eukaryotic ATPase epsilon family.
Belongs to the carboxylate-amine ligase family. Glutamate--cysteine ligase type 2 subfamily.
Homodimer or monomer when oxidized or reduced, respectively.
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.
Belongs to the UbiA prenyltransferase family.
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Divalent metal cations. Prefers magnesium or manganese.
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Belongs to the eukaryotic initiation factor 4E family.
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
Belongs to the Mediator complex subunit 31 family.
Belongs to the TFIIF alpha subunit family.
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Belongs to the phosphatase 2A regulatory subunit B family.
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
Mediates both low-affinity uptake and efflux of sugar across the membrane.
Belongs to the V-ATPase V0D/AC39 subunit family.
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.